{"id":3376,"date":"2018-06-26T01:00:00","date_gmt":"2018-07-27T06:44:34","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/cpu%e5%89%8d%e6%b2%bf%ef%bd%9c%e6%9c%80%e6%96%b0%e7%a7%91%e7%a0%94%e8%bf%9b%e5%b1%95\/"},"modified":"2018-07-27T14:44:40","modified_gmt":"2018-07-27T06:44:40","slug":"cpu%e5%89%8d%e6%b2%bf%ef%bd%9c%e6%9c%80%e6%96%b0%e7%a7%91%e7%a0%94%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/3376\/","title":{"rendered":"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55"},"content":{"rendered":"
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\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/section>\n<\/section>\n
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\u3000\u3000\u300a\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\u300b\u4e3b\u8981\u5411\u60a8\u62a5\u9053\u4e0a\u4e00\u4e2a\u6708\u7684\u836f\u5927\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\u3002\u5e0c\u671b\u80fd\u65b9\u4fbf\u5e7f\u5927CPUer\u66f4\u591a\u4e86\u89e3\u836f\u5927\u79d1\u7814\u60c5\u51b5\u3002\u79d1\u6280\u521b\u65b0\uff0c\u7825\u783a\u524d\u884c\u3002\uff08\u4ee5\u4e0b\u6587\u7ae0\u6309\u7167\u5b66\u79d1\u6392\u5e8f\u3002\uff09<\/span><\/p>\n<\/section>\n

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Adv Funct Mater | \u987e\u6708\u6e05\u56e2\u961f\u62a5\u9053\u4e73\u817a\u764c\u8f6c\u79fb\u8bca\u7597\u63a2\u9488<\/span>
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\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/span><\/p>\n

\u3000\u3000<\/span><\/span>\u8fd1\u65e5\uff0c\u6750\u6599\u5b66\u9886\u57df\u77e5\u540d\u671f\u520aAdvanced Functional Materials(\u5f71\u54cd\u56e0\u5b50 12.124)\u53d1\u8868\u4e86\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u5de5\u5b66\u9662\u987e\u6708\u6e05\u6559\u6388\u8bfe\u9898\u7ec4\u6700\u65b0\u7814\u7a76\u6210\u679c\u2014\u2014<\/span>Targeting CXCR4\u2013CXCL12 Axis for Visualizing, Predicting, and Inhibiting Breast Cancer Metastasis with Theranostic AMD3100\u2013Ag2S Quantum Dot Probe\u3002\u535a\u58eb\u751f\u738b\u671d\u8f89\u548c\u9a6c\u794e\u535a\u58eb\u4e3a\u672c\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u987e\u6708\u6e05\u6559\u6388\u4e3a\u672c\u6587\u7684\u901a\u8baf\u4f5c\u8005\u3002<\/span><\/span><\/p>\n

Fig 1. AMD3100-\u91cf\u5b50\u70b9\u7f00\u5408\u7269<\/span>\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/p>\n

\u4e73\u817a\u764c\u8f6c\u79fb\u4e00\u76f4\u662f\u4e34\u5e8a\u4e0a\u8bca\u65ad\u6cbb\u7597\u7684\u96be\u9898\uff0c\u800cCXCR4\u4f5c\u4e3a\u4e73\u817a\u764c\u590d\u53d1\u548c\u8f6c\u79fb\u7684\u6807\u5fd7\u7269<\/span>\u5f15\u8d77\u4e86\u6781\u5927\u7684\u91cd\u89c6\uff0c\u591a\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u53d1\u73b0CXCR4\u7684\u9ad8\u8868\u8fbe\u4e0e\u4e73\u817a\u764c\u8f6c\u79fb\u6709\u5173\u8054\u3002\u987e\u6708\u6e05\u6559\u6388\u56e2\u961f\u5bf9CXCR4\u62ee\u6297\u5242AMD3100\u8fdb\u884c\u5de7\u5999\u7684\u7ed3\u6784\u4fee\u9970\uff0c\u5f15\u5165\u786b\u5316\u94f6\u91cf\u5b50\u70b9\u3002\u7531\u4e8e\u786b\u5316\u94f6\u91cf\u5b50\u70b9\u53ef\u4ee5\u5b9e\u73b0\u8fd1\u7ea2\u5916\u8367\u5149\u68c0\u6d4b\u5e76\u4e14\u53ef\u4ee5\u5b9e\u73b0\u5149\u70ed\u6cbb\u7597\uff0c\u5c06AMD3100\u4e0e\u786b\u5316\u94f6\u7f00\u5408\u540e\u53ef\u4ee5\u5b9e\u73b0\u4e73\u817a\u764c\u8f6c\u79fb\u7684\u4e00\u4f53\u5316\u8bca\u6cbb\u3002\u4f53\u5185\u5916\u7684\u5b9e\u9a8c\u7ed3\u679c\u4e5f\u8868\u660e\uff0c\u57fa\u4e8eAMD3100\u7684\u91cf\u5b50\u70b9\u63a2\u9488\u53ef\u4ee5\u5b9e\u73b0\u4e73\u817a\u764c\u7684\u53d1\u73b0\u548c\u6cbb\u7597\u3002<\/span><\/p>\n

\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/p>\n

Fig 2. AMD3100\u91cf\u5b50\u70b9\u63a2\u9488\u5b9e\u73b0\u6d3b\u4f53\u80bf\u7624\u8bca\u6cbb<\/span><\/p>\n


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\u6b64\u9879\u5de5\u4f5c\u5de7\u5999\u5730\u5c06CXCR4\u62ee\u6297\u5242\u548c\u786b\u5316\u94f6\u91cf\u5b50\u70b9\u7f00\u5408\uff0c\u5b9e\u73b0\u4e86\u539f\u53d1\u6027\u4e73\u817a\u764c\u548c\u80ba\u8f6c\u79fb\u80bf\u7624\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u3002\u8bfe\u9898\u7ec4\u5145\u5206\u53d1\u6325\u91cf\u5b50\u70b9\u7684\u7279\u6027\uff0c\u5b9e\u73b0\u4e86\u8bca\u65ad\u548c\u5149\u70ed\u6cbb\u7597\u4e00\u4f53\u5316\uff0c\u4e3a\u4e73\u817a\u764c\u7684\u6cbb\u7597\u4ee5\u53ca\u590d\u53d1\u3001\u8f6c\u79fb\u7684\u8bca\u6cbb\u63d0\u4f9b\u4e86\u65b0\u7684\u624b\u6bb5\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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Nanoscale | \u987e\u6708\u6e05\u56e2\u961f\u62a5\u9053\u68c0\u6d4b\u4e00\u6c27\u5316\u6c2e\u7eb3\u7c73\u63a2\u9488<\/span><\/strong><\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u8fd1\u65e5\uff0c\u7eb3\u7c73\u6750\u6599\u9886\u57df\u77e5\u540d\u671f\u520aNanoscale(\u5f71\u54cd\u56e0\u5b50 7.367)\u5728\u7ebf\u53d1\u8868\u4e86\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u987e\u6708\u6e05\u6559\u6388\u56e2\u961f\u5728\u4e00\u6c27\u5316\u6c2e\u68c0\u6d4b\u9886\u57df\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c\u2014\u2014808nm light-excited upconversion nanoprobe based on LRET for the ratiometric detection of nitric oxide in living cancer cells\u3002<\/span><\/p>\n

\u4e00\u6c27\u5316\u6c2e\u662f\u660e\u661f\u6c14\u4f53\u5206\u5b50\uff0c\u4f5c\u4e3a\u91cd\u8981\u7684\u4fe1\u53f7\u5206\u5b50\u53c2\u4e0e\u4e86\u591a\u79cd\u751f\u7406\u3001\u75c5\u7406\u8fc7\u7a0b\uff0c\u56e0\u6b64\u5bf9\u4e00\u6c27\u5316\u6c2e\u7684\u68c0\u6d4b\u4e00\u76f4\u662f\u70ed\u95e8\u7684\u7814\u7a76\u9886\u57df\u3002\u4ee5\u5f80\u7684\u5c0f\u5206\u5b50\u4e00\u6c27\u5316\u6c2e\u8367\u5149\u63a2\u9488\u591a\u53d7\u9650\u4e8e\u8f83\u77ed\u7684\u65af\u6258\u514b\u65af\u4f4d\u79fb\uff0c\u5e76\u4e14\u591a\u4e3a\u6bd2\u6027\u8f83\u5927\u7684\u5316\u5408\u7269\u3002\u56e0\u6b64\uff0c\u987e\u6708\u6e05\u6559\u6388\u56e2\u961f\u8bbe\u8ba1\u5e76\u5408\u6210\u4e86\u53ef\u4ee5\u7531808nm\u6fc0\u5149\u6fc0\u53d1\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u63a2\u9488\uff08\u5176\u7ec4\u6210\u4e3a\uff1aNaYF4<\/span>:18%Yb, 0.5%Nd, 1%Er@NaYF4<\/span>:20%Nd (UCNPs), RhBs \u548c PAA-octylamine\uff09\u3002\u5982\u56fe\u6240\u793a\uff0c\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5728808nm\u6fc0\u5149\u7684\u6fc0\u53d1\u4e0b\u53ef\u4ee5\u901a\u8fc7Nd\u79bb\u5b50\u88ab\u654f\u5316\uff0c\u4ece\u800c\u4f5c\u4e3a\u80fd\u91cf\u4f9b\u4f53\u3002\u800c\u7f57\u4e39\u660e\u87ba\u5185\u9170\u80fa\u5316\u5408\u7269RhBs\u5728\u4e0e\u4e00\u6c27\u5316\u6c2e\u53d1\u751f\u53cd\u5e94\u540e\u53ef\u4ee5\u91ca\u653e\u51fa\u7f57\u4e39\u660e\u7684\u7ed3\u6784\u4ece\u800c\u4f5c\u4e3a\u80fd\u91cf\u53d7\u4f53\u3002PAA-octylamine\u662f\u4e24\u4eb2\u6027\u80f6\u675f\uff0c\u6539\u5584\u4f53\u7cfb\u6c34\u6eb6\u6027\u7b49\u6027\u8d28\u3002\u5728808nm\u6fc0\u5149\u6fc0\u53d1\u540e\uff0c\u8fd9\u4e00\u7eb3\u7c73\u4f53\u7cfb\u53ef\u4ee5\u901a\u8fc7\u4e0a\u8f6c\u6362\u53d1\u5149\uff0c\u53d1\u5c04540nm\/660nm\u7684\u4fe1\u53f7\uff0c\u4ece\u800c\u5b9e\u73b0\u5bf9\u4e00\u6c27\u5316\u6c2e\u7684\u68c0\u6d4b\u3002\u540e\u7eed\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u8fd9\u4e00\u7eb3\u7c73\u4f53\u7cfb\u786e\u5b9e\u53ef\u4ee5\u5b9e\u73b0\u6d3b\u7ec6\u80de\u6c34\u5e73\u4e0a\u68c0\u6d4b\u4e00\u6c27\u5316\u6c2e\uff0c\u5e76\u4e14\u5177\u6709\u6781\u597d\u7684\u9009\u62e9\u6027\u548c\u7075\u654f\u5ea6\u3002<\/span><\/p>\n


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\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/p>\n

Fig 1.\u4e00\u6c27\u5316\u6c2e\u68c0\u6d4b\u4f53\u7cfb\u8bbe\u8ba1\u601d\u8def<\/span><\/p>\n


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\u6b64\u9879\u5de5\u4f5c\u57fa\u4e8e\u4e0a\u8f6c\u6362\u53d1\u5149\u6784\u5efa\u4e86\u4e00\u6c27\u5316\u6c2e\u68c0\u6d4b\u7684\u7eb3\u7c73\u4f53\u7cfb\uff0c\u8fd9\u4e00\u6c34\u6eb6\u6027\u7684\u4f53\u7cfb\u53ef\u4ee5\u5b9e\u73b0\u6d3b\u7ec6\u80de\u6c34\u5e73\u4e0a\u9ad8\u7075\u654f\u6027\u548c\u9ad8\u9009\u62e9\u6027\u5730\u68c0\u6d4b\u4e00\u6c27\u5316\u6c2e\u3002\u8fd9\u4e3a\u4e00\u6c27\u5316\u6c2e\u9886\u57df\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u5de5\u5177\u548c\u624b\u6bb5\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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J Hematol Oncol | \u595a\u6d9b\u3001\u590f\u7389\u51e4\u5408\u4f5c\u62a5\u9053\u7ade\u4e89\u6027\u5185\u6e90RNA\u4e0e\u80bf\u7624\u53d1\u751f\u53d1\u5c55\u673a\u5236\u7814\u7a76\u65b0\u8fdb\u5c55<\/span><\/strong><\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/p>\n

\u8457\u540d\u80bf\u7624\u5b66\u671f\u520aJournal of Hematology & Oncology(\u5f71\u54cd\u56e0\u5b50 6.35)\u5728\u7ebf\u53d1\u8868\u4e86\u595a\u6d9b\u6559\u6388\u548c\u590f\u7389\u51e4\u6559\u6388<\/span>\u8bfe\u9898\u7ec4\u6700\u65b0\u79d1\u7814\u6210\u679c—STARD13-correlated ceRNA network-directed inhibition on YAP\/TAZ activity suppresses stemness ofbreast cancer via co-regulating Hippo and Rho-GTPase\/F-actin signaling\u3002\u595a\u6d9b\u6559\u6388\u548c\u590f\u7389\u51e4\u6559\u6388\u4e3a\u672c\u6587\u7684\u5171\u540c\u901a\u4fe1\u4f5c\u8005\uff0c\u90d1\u7984\u67ab\u535a\u58eb\u540e\u548c\u5411\u81e3\u5e0c\u535a\u58eb\u4e3a\u672c\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002<\/span><\/p>\n

       \u595a\u6d9b\u6559\u6388\u8bfe\u9898\u7ec4\u8fd1\u5e74\u6765\u5728\u7ade\u4e89\u6027\u5185\u6e90RNA\uff08ceRNA\uff09\u7f51\u7edc\u4e0e\u80bf\u7624\u53d1\u751f\u53d1\u5c55\u9886\u57df\uff0c\u5c24\u5176\u662f\u4e73\u817a\u764c\u53d1\u751f\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528\u5f00\u5c55\u4e86\u5927\u91cf\u7684\u7814\u7a76\u5de5\u4f5c\u3002\u8bfe\u9898\u7ec4\u5728\u524d\u671f\u5de5\u4f5c\u57fa\u7840\u4e0a\u901a\u8fc7\u4f53\u5185\u5916\u7814\u7a76\u53d1\u73b0\u6291\u764c\u57fa\u56e0STARD13\u76f8\u5173ceRNA\u7f51\u7edc\u53ef\u6291\u5236\u4e73\u817a\u764c\u7ec6\u80de\u7684\u5e72\u6027\uff0c\u8fdb\u4e00\u6b65\u901a\u8fc7\u9ad8\u901a\u91cf\u6d4b\u5e8f\u53d1\u73b0\u8be5ceRNA\u7f51\u7edc\u53ef\u901a\u8fc7\u540c\u65f6\u6fc0\u6d3bHippo\u4fe1\u53f7\u901a\u8def\u548c\u6291\u5236Rho-GTPase\/F-actin\u4fe1\u53f7\u901a\u8def\u6765\u53d1\u6325\u4f5c\u7528\uff0c\u5e76\u4e14\u8be5ceRNA\u7f51\u7edc\u7684\u53d1\u751f\u53ef\u589e\u5f3a\u4e73\u817a\u764c\u7ec6\u80de\u5bf9\u5316\u7597\u836f\u7269\u963f\u9709\u7d20\u7684\u654f\u611f\u6027\u3002<\/span><\/p>\n

\u6b64\u7814\u7a76\u5bf9\u4e8eSTARD13\u76f8\u5173ceRNA\u7f51\u7edc\u7684\u529f\u80fd\u8fdb\u884c\u4e86\u6df1\u5165\u7814\u7a76\uff0c\u8fd9\u5bf9\u5f00\u53d1\u9776\u5411\u6fc0\u6d3b\u8be5ceRNA\u7f51\u7edc\u7684\u6cbb\u7597\u4e73\u817a\u764c\u7684\u836f\u7269\u6709\u7740\u91cd\u8981\u7684\u610f\u4e49\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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Theranostics | \u5c39\u8389\u82b3\u3001\u4f55\u4f1f\u56e2\u961f\u62a5\u9053\u65b0\u578b\u86cb\u767d\u9012\u9001\u7b56\u7565<\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u86cb\u767d\u6cbb\u7597\u5728\u75be\u75c5\u7684\u6cbb\u7597\u4e2d\u53d1\u6325\u7740\u6108\u53d1\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u4e14\u4e0e\u57fa\u56e0\u6cbb\u7597\u76f8\u6bd4\uff0c\u662f\u4e00\u79cd\u66f4\u4e3a\u5b89\u5168\u7684\u6cbb\u7597\u65b9\u5f0f\uff1b\u4f46\u662f\uff0c\u86cb\u767d\u7c7b\u836f\u7269\u6781\u6613\u88ab\u9176\u964d\u89e3\u3001\u819c\u6e17\u900f\u6027\u5dee\uff0c\u4e14\u5546\u54c1\u5316\u7684\u86cb\u767d\u9012\u9001\u8f7d\u4f53\u5f88\u96be\u7ed5\u5f00\u5185\u6db5\u4f53-\u6eb6\u9176\u4f53\u9014\u5f84\u5b9e\u73b0\u80de\u6d46\u9012\u9001\uff0c\u9012\u9001\u6548\u7387\u4f4e\uff08< 2%\uff09\u662f\u86cb\u767d\u7c7b\u836f\u7269\u9ad8\u6548\u9012\u9001\u7684\u4e3b\u8981\u74f6\u9888\u3002<\/span><\/p>\n

\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u5c39\u8389\u82b3\u6559\u6388\u548c\u4f55\u4f1f\u526f\u6559\u6388\u5728\u751f\u7269\u533b\u5b661\u533a\u6742\u5fd7Theranostics<\/strong> (\u5f71\u54cd\u56e0\u5b50 8.766)\u4e0a\u53d1\u8868\u8bba\u6587\u2014\u2014Drug-delivering-drug platform-mediated potent protein therapeutics via a non-endo-lysosomal route\u3002\u6b64\u9879<\/span>\u5de5\u4f5c\u4e3b\u8981\u7531\u535a\u58eb\u751f\u8f9b\u6653\u6590\u3001\u817e\u8d85\u7b49\u5b8c\u6210\u3002\u4f9d\u9760\u524d\u671f\u62a5\u9053\u7684\u201c\u836f\u7269-\u9012\u9001-\u836f\u7269\uff08drug-delivering-drug,DDD\uff09\u201d\u5e73\u53f0\uff08<\/span>Advanced Science, 2017 4(11):1700324<\/a>\uff09\uff0c\u91c7\u7528\u6746\u72b6\u7d2b\u6749\u9187\uff08paclitaxel, PTX\uff09\u7eb3\u7c73\u6676\u9012\u9001\u86cb\u767d\u836f\u7269Caspase3\u3002\u518d\u4e00\u6b21\u8bc1\u660e\uff0c\u9664\u4e86\u57fa\u56e0\u836f\u7269\u5916\uff0c\u4f53\u7cfb\u4e5f\u80fd\u7ed5\u5f00\u5185\u6db5\u4f53-\u6eb6\u9176\u4f53\u7cfb\u7edf\u9012\u9001\u86cb\u767d\u836f\u7269\u5165\u80de\u3002<\/span><\/p>\n


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\u8be5\u4f53\u7cfb\u5b9e\u73b0\u4e86\u5c0f\u5206\u5b50\u836f\u7269PTX\u548cCaspase 3\u975e\u5185\u6db5\u4f53-\u6eb6\u9176\u4f53\u9014\u5f84\u7684\u80de\u6d46\u5171\u9012\u9001\uff0c\u5c0f\u5206\u5b50\u836f\u7269\u8f7d\u836f\u91cf\u6781\u9ad8\uff0c\u86cb\u767d\u7c7b\u836f\u7269\u9012\u9001\u9ad8\u6548\uff0c\u5c0f\u5206\u5b50\u548c\u86cb\u767d\u7c7b\u836f\u7269\u7684\u534f\u540c\u4f5c\u7528\u663e\u8457\uff0c\u4e3a\u57fa\u56e0\u3001\u86cb\u767d\u3001\u591a\u80bd\u548c\u6297\u4f53\u7b49\u5927\u5206\u5b50\u7c7b\u836f\u7269\u63d0\u4f9b\u4e86\u4e00\u79cd\u5b89\u5168\u9ad8\u6548\u7684\u9012\u9001\u5e73\u53f0\u3002\u6e05\u534e\u5927\u5b66Weiping Gao (\u9ad8\u536b\u5e73)\u6559\u6388\u5e94\u4e3b\u7f16\u7684\u9080\u8bf7\u5bf9\u8be5\u6587\u8fdb\u884c\u4e86\u8bc4\u8ff0\u2014\u2014Drug nanorods are potential as newnanocarriers for intracellular protein delivery<\/strong>.<\/span><\/p>\n

\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u4f55\u4f1f\u526f\u6559\u6388\u548c\u5c39\u8389\u82b3\u6559\u6388\u4e3a\u6587\u7ae0\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff0c\u8bfe\u9898\u7ec4\u6210\u5458\u8f9b\u6653\u6590\u4e3a\u6587\u7ae0\u7684\u7b2c\u4e00\u4f5c\u8005\u3002\u8be5\u7814\u7a76\u5f97\u5230\u4e86\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u9879\u76ee\uff08\u9879\u76ee\u7f16\u53f7\uff1a81673377\uff0c81473152\uff0c81402869\uff09\u548c\u6c5f\u82cf\u7701\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u9879\u76ee\uff08\u9879\u76ee\u7f16\u53f7\uff1aBK20140671\uff09\u7b49\u7684\u8d44\u52a9\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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Chin J Nat Med | \u5b59\u5b8f\u658c\u3001\u67f3\u519b\u56e2\u961f\u62a5\u9053\u9f50\u58a9\u679c\u9178\u964d\u8840\u8102\u5c0f\u89c4\u6a21\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c<\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u8fd1\u65e5\uff0c\u6700\u65b0\u4e00\u671f\u7684Chinese Journal of Natural Medicines<\/strong>(\u5f71\u54cd\u56e0\u5b50 1.667)\u62a5\u9053\u4e86\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u5b59\u5b8f\u658c\u6559\u6388\u548c\u67f3\u519b\u526f\u7814\u7a76\u5458\u5728\u964d\u8840\u8102\u836f\u7269\u7814\u53d1\u9886\u57df\u7684\u6700\u65b0\u6210\u679c\u2014\u2014Lipid-lowering effects of oleanolic acid in hyperlipidemic patients\u3002\u5b59\u5b8f\u658c\u6559\u6388\u548c\u67f3\u519b\u526f\u7814\u7a76\u5458\u662f\u672c\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/span><\/span><\/p>\n

\u9f50\u58a9\u679c\u9178\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u4e94\u73af\u4e09\u841c\u7c7b\u5316\u5408\u7269\u3002\u65e9\u5728\u4e0a\u4e16\u7eaa\u4e03\u5341\u5e74\u4ee3\uff0c\u9f50\u58a9\u679c\u9178\u5c31\u5df2\u7ecf\u5728\u4e34\u5e8a\u4e0a\u4f5c\u4e3a\u4fdd\u809d\u836f\u800c\u88ab\u5e7f\u6cdb\u4f7f\u7528\u3002\u7814\u7a76\u56e2\u961f\u5728\u524d\u671f\u7684\u52a8\u7269\u5b9e\u9a8c\u4e2d\u53d1\u73b0\u9f50\u58a9\u679c\u9178\u6709\u7740\u964d\u8840\u8102\u7684\u7597\u6548\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u56e2\u961f\u548c\u6c5f\u82cf\u7701\u4eba\u6c11\u533b\u9662\u5408\u4f5c\u5f00\u5c55\u4e86\u6b64\u9879\u5c0f\u89c4\u6a21\u7684\u6982\u5ff5\u9a8c\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002\u53d7\u8bd5\u8005\u6bcf\u5929\u670d\u7528\u4e09\u6b21\uff0c\u6bcf\u6b21\u56db\u7247\u9f50\u58a9\u679c\u9178\u3002\u8bd5\u9a8c\u5468\u671f\u4e3a4\u5468\uff0c\u53c2\u4e0e\u8bd5\u9a8c\u524d\u540e\u53d6\u8840\u6837\u68c0\u6d4b\u76f8\u5173\u7684\u751f\u5316\u6307\u6807\u3002\u5bf9\u5176\u4e2d\u4e09\u540d\u53d7\u8bd5\u8005\u7684\u8840\u6837\u8fdb\u884c\u7684DNA\u5fae\u9635\u5217\u7814\u7a76\u3002\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u670d\u7528\u4e86\u9f50\u58a9\u679c\u9178\u540e\uff0c\u53d7\u8bd5\u8005\u7684TC\uff0cTG\u4ee5\u53caHDLC\u5747\u6709\u663e\u8457\u4e0b\u964d\u3002DNA\u5fae\u9635\u5217\u7ed3\u679c\u8868\u660e\u670921\u79cdmRNA\u51fa\u73b0\u663e\u8457\u4e0b\u964d\u3002\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u7ed3\u679c\u8868\u660e\u670917\u79cdmRNA\u51fa\u73b0\u4e0a\u8c03\uff0c4\u79cd\u4e0b\u8c03\u3002\u968f\u540e\u9009\u62e9\u4e86\u5176\u4e2d\u4e94\u79cdmRNA(<\/span>CACNA1B\uff0cFCN\uff0cSTEAP3\uff0cAMPH\u4ee5\u53caNR6A1)\u7684\u8868\u8fbe\u6c34\u5e73\u8fdb\u884c\u9a8c\u8bc1\u3002<\/span><\/p>\n

\u6b64\u9879\u7814\u7a76\u5c3d\u7ba1\u53ea\u662f\u5c0f\u89c4\u6a21\u7684\u6982\u5ff5\u9a8c\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u662f\u7ed3\u679c\u8868\u660e\u9f50\u58a9\u679c\u9178\u53ef\u4ee5\u6539\u5584\u9ad8\u8102\u8840\u75c7\uff0c\u8fd9\u5bf9\u540e\u7eed\u7814\u7a76\u9f50\u58a9\u679c\u9178\u7684\u836f\u7406\u4f5c\u7528\u6709\u7740\u91cd\u8981\u7684\u6307\u5bfc\u610f\u4e49\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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J Med Chem | \u67e5\u6653\u660e\u56e2\u961f\u53d1\u8868mIDH1\/2\u6291\u5236\u5242\u7efc\u8ff0\u6587\u7ae0<\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u8fd1\u65e5\uff0c\u836f\u7269\u5316\u5b66\u9886\u57df\u6743\u5a01\u671f\u520aJournal of Medicinal Chemistry(\u5f71\u54cd\u56e0\u5b50 6.259)\u5728\u7ebf\u53d1\u8868\u4e86\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u5de5\u5b66\u9662\u67e5\u6653\u660e\u526f\u7814\u7a76\u5458\u56e2\u961f\u6709\u5173\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176\u6291\u5236\u5242\u76f8\u5173\u7efc\u8ff0\u6587\u7ae0\u2014\u2014<\/span>Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1\/2): an Update and Perspective\u3002\u67e5\u6653\u660e\u526f\u7814\u7a76\u5458\u4e3a\u672c\u6587\u7684\u901a\u8baf\u4f5c\u8005\u3002 <\/span><\/span><\/span><\/p>\n

\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176(IDH)\u662f\u4e00\u79cd\u91cd\u8981\u7684\u4ee3\u8c22\u9176\uff0c\u5176\u4e3b\u8981\u4f5c\u7528\u662f\u50ac\u5316\u5f02\u67e0\u6aac\u9178\u751f\u6210\u03b1-\u916e\u620a\u4e8c\u9178\u3002\u800c\u7a81\u53d8\u578b\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176(mIDH)\u53ef\u4ee5\u5c06\u03b1-\u916e\u620a\u4e8c\u9178\u8fdb\u4e00\u6b65\u50ac\u5316\u751f\u62102-\u7f9f\u57fa\u620a\u4e8c\u9178(2-HG)\u30022-HG\u542b\u91cf\u5347\u9ad8\u540e\u53ef\u4ee5\u5bfc\u81f4\u7ec6\u80de\u5206\u5316\u53d7\u635f\u5e76\u4e14\u4fc3\u4f7f\u80bf\u7624\u53d1\u751f\u3002\u56e0\u6b64\u7a81\u53d8\u578b\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176\u6210\u4e3a\u4e86\u70ed\u95e8\u7684\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u7684\u9776\u70b9\u3002\u591a\u79cdmIDH\u6291\u5236\u5242\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u5176\u4e2dCelgene\u516c\u53f8\u7814\u53d1\u7684mIDH2\u6291\u5236\u5242enasidenib\u5df2\u7ecf\u83b7\u5f97FDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u3002\u6b64\u7bc7\u7efc\u8ff0\u6587\u7ae0\u7efc\u8ff0\u4e86mIDH\u6291\u5236\u5242\u7684\u5206\u5b50\u7ed3\u6784\u57fa\u7840\uff0c\u5e76\u603b\u7ed3\u4e86\u8fd1\u5e74\u6765\u7684\u6291\u5236\u5242\u7814\u53d1\u8fdb\u5c55\u3002<\/span><\/p>\n

\u8fd1\u5e74\u6765\u5b66\u672f\u754c\u548c\u5de5\u4e1a\u754c\u8d8a\u6765\u8d8a\u91cd\u89c6\u4e0e\u80bf\u7624\u4ee3\u8c22\u76f8\u5173\u9776\u70b9\u7684\u836f\u7269\u7814\u53d1\u3002\u56e0\u6b64\uff0c\u5c06\u5176\u4ed6\u80bf\u7624\u4ee3\u8c22\u76f8\u5173\u7684\u836f\u7269\u4e0emIDH\u6291\u5236\u5242\u8054\u7528\u6216\u8bb8\u4e5f\u662f\u4eca\u540e\u7814\u7a76\u7684\u91cd\u8981\u7b56\u7565\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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J Med Chem | <\/strong>\u5c24\u542f\u51ac\u3001\u5f20\u6653\u8fdb\u56e2\u961f\u62a5\u9053\u65b0\u578bPHD2\u6291\u5236\u5242<\/strong><\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u8fd1\u65e5\uff0c\u836f\u7269\u5316\u5b66\u9886\u57df\u6743\u5a01\u671f\u520aJournal of Medicinal Chemistry(\u5f71\u54cd\u56e0\u5b50 6.259)\u5728\u7ebf\u53d1\u8868\u4e86\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u5c24\u542f\u51ac\u3001\u5f20\u6653\u8fdb\u56e2\u961f\u5728PHD2\u6291\u5236\u5242\u7814\u53d1\u9886\u57df\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u2014\u2014Click Chemistry\u2013based Discovery of [3-Hydroxy-5- (1H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia\u3002\u7855\u58eb\u7814\u7a76\u751f\u4f0d\u60a6\u540c\u5b66\u4e3a\u672c\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\uff0c\u5c24\u542f\u51ac\u6559\u6388\u548c\u5f20\u6653\u8fdb\u526f\u6559\u6388\u4e3a\u672c\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/span><\/p>\n


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Fig 1. \u8bfe\u9898\u8bbe\u8ba1\u601d\u8def<\/span><\/p>\n


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PHD2\u5168\u79f0\u4e3aProlyl Hydroxylase 2\u3002\u65e9\u524d\u7684\u7814\u7a76\u53d1\u73b0PHD2\u548c\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50HIF\u6709\u7740\u5bc6\u5207\u8054\u7cfb\u3002\u5728\u6b63\u5e38\u6c27\u6c34\u5e73\u60c5\u51b5\u4e0b\uff0cPHD2\u53ef\u4ee5\u4f7f\u5f97HIF\u7684\u812f\u6c28\u9178\u6b8b\u57fa\u53d1\u751f\u7f9f\u57fa\u5316\uff0c\u4ece\u800c\u4f7f\u5f97HIF\u88abVHL\u6240\u8bc6\u522b\uff0c\u968f\u540e\u88ab\u964d\u89e3\u3002\u800c\u5728\u6162\u6027\u80be\u75c5\u6216\u8005\u63a5\u53d7\u5316\u7597\u7684\u764c\u75c7\u60a3\u8005\u4e2d\uff0c\u8d2b\u8840\u65f6\u5e38\u51fa\u73b0\u3002\u800cHIF\u4f5c\u4e3a\u8f6c\u5f55\u56e0\u5b50\u76f4\u63a5\u8d1f\u8d23\u8c03\u8282\u7ea2\u7ec6\u80de\u751f\u6210\u7d20EPO\u7684\u8868\u8fbe\u3002\u56e0\u6b64\uff0c\u5e72\u9884HIF-PHD2\u53ef\u4ee5\u6709\u6548\u6cbb\u7597\u8fd9\u7c7b\u8d2b\u8840\u3002\u5c24\u542f\u51ac\u3001\u5f20\u6653\u8fdb\u56e2\u961f\u8fd1\u5e74\u6765\u56f4\u7ed5PHD2\u8fd9\u4e00\u9776\u70b9\u8fdb\u884c\u4e86\u6df1\u5165\u7cfb\u7edf\u7684\u7814\u7a76\uff0c\u5728\u6b64\u9879\u5de5\u4f5c\u4e2d\uff0c\u7814\u7a76\u56e2\u961f\u57fa\u4e8e\u70b9\u51fb\u5316\u5b66\u5408\u6210\u4e86\u4e00\u7cfb\u5217\u4e09\u6c2e\u5511\u7684\u5316\u5408\u7269\uff0c\u6df1\u5165\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u6700\u4f18\u7684\u5316\u5408\u726915i<\/strong>\u6d3b\u6027\u8fbe\u5230\u9633\u6027\u836fFG-4592\u7684\u5341\u500d\u3002\u4f53\u5185\u7814\u7a76\u4e5f\u53d1\u73b0\uff0c15i<\/strong>\u53ef\u4ee5\u6709\u6548\u6cbb\u7597\u80be\u6027\u8d2b\u8840\u5e76\u4e14\u65e0\u660e\u663e\u7684\u526f\u4f5c\u7528\uff0c\u6709\u671b\u8fdb\u884c\u540e\u7eed\u6df1\u5165\u7684\u7814\u7a76\u3002<\/span><\/p>\n

\u6b64\u9879\u5de5\u4f5c\u5229\u7528\u70b9\u51fb\u5316\u5b66\uff0c\u7b80\u5316\u4e86\u5316\u5408\u7269\u7684\u5408\u6210\u96be\u5ea6\uff0c\u53ef\u4ee5\u9ad8\u6548\u5408\u6210\u76ee\u7684\u5316\u5408\u7269\u3002\u4f53\u5185\u5916\u7814\u7a76\u4e5f\u8868\u660e\u8fd9\u4e00\u5316\u5408\u7269\u6709\u826f\u597d\u7684\u6d3b\u6027\uff0c\u503c\u5f97\u8fdb\u884c\u6df1\u5165\u7684\u7814\u7a76\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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Science | \u8096\u6613\u500d\u6559\u6388\u62a5\u9053CRISPR-Cas\u6700\u65b0\u7814\u7a76\u6210\u679c<\/span><\/strong><\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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6\u67087\u65e5\uff0c\u9876\u7ea7\u671f\u520aScience<\/em><\/strong><\/span>\u5728\u7ebf\u53d1\u8868\u4e86\u5eb7\u5948\u5c14\u5927\u5b66Ailong Ke\u6559\u6388\u548c\u54c8\u4f5b\u533b\u5b66\u9662\u5ed6\u8302\u5bcc\u535a\u58eb\u56e2\u961f\u6700\u65b0\u7684\u5408\u4f5c\u7814\u7a76\u6210\u679c\u2014\u2014Structure basis for RNA-guided DNA degradation by Cascade and Cas3\u3002\u5eb7\u5948\u5c14\u5927\u5b66Ailong Ke\u6559\u6388\u548c\u54c8\u4f5b\u533b\u5b66\u9662\u52a9\u7406\u6559\u6388\u5ed6\u8302\u5bcc\u535a\u58eb\u4e3a\u672c\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff0c\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u836f\u5b66\u9662\u836f\u7406\u7cfb\u8096\u6613\u500d\u6559\u6388(<\/strong>\u5165\u9009\u7b2c\u5341\u56db\u6279\u201c\u5343\u4eba\u8ba1\u5212\u201d\u9752\u5e74\u9879\u76ee<\/a>)<\/strong>\u548c\u54c8\u4f5b\u533b\u5b66\u9662Min Luo\u535a\u58eb\u4e3a\u672c\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002
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CRIPR-Cas\u7cfb\u7edf\u8fd1\u5e74\u6765\u6210\u4e3a\u57fa\u56e0\u7f16\u8f91\u9886\u57df\u7684\u6700\u70ed\u95e8\u7684\u7814\u7a76\u65b9\u5411\u3002\u5176\u4e2d\u2160\u578bCRISPR-Cas\u7cfb\u7edf\u5176\u6700\u5927\u7684\u7279\u70b9\u5c31\u662f\u901a\u8fc7Cascade\u590d\u5408\u4f53\u548cCas3\u5206\u522b\u5728\u53cc\u94feDNA\u4e0a\u8fde\u7eed\u7684\u9776\u70b9\u641c\u7d22\u548c\u964d\u89e3\u7684\u8fc7\u7a0b\u3002Cascade\u590d\u5408\u4f53\u5bf9DNA\u9776\u70b9\u7684\u641c\u7d22\u662f\u7531crRNA\u5f15\u5bfc\u7684\uff0c\u800cCas3\u662f\u4e00\u4e2a\u6838\u9178\u9176-\u89e3\u65cb\u9176\u878d\u5408\u9176\u53ef\u4ee5\u5bf9\u9776\u70b9DNA\u8fdb\u884c\u89e3\u87ba\u65cb\u548c\u5207\u5272\u3002\u7814\u7a76\u4eba\u5458\u5229\u7528\u51b7\u51bb\u7535\u955c\u83b7\u5f97\u4e86\u5206\u8fa8\u7387\u5206\u522b\u4e3a3.7\u548c4.7\u00c5\u7684pre-nicking\u548cpost-nicking\u72b6\u6001\u4e0b\u7684<\/span>Type I-E Cascade\/R-loop\/Cas3\u590d\u5408\u4f53\u7684\u6676\u4f53\u7ed3\u6784\u3002\u901a\u8fc7\u8fd9\u4e24\u4e2a\u6676\u4f53\u7ed3\u6784\u4ece\u800c\u77e5\u9053\u4e3a\u4f55Cas3\u53ef\u4ee5\u7279\u5f02\u6027\u8bc6\u522bR-loop\u5f62\u6210\u7684Cascade\u800c\u4e0d\u4f1a\u53d1\u751f\u8131\u9776\u5e76\u4e14\u63ed\u793a\u4e86Cas3\u662f\u5982\u4f55\u4ece\u8d77\u59cb\u7684nicking\u6a21\u5f0f\u8f6c\u53d8\u6210\u4e3aDNA\u964d\u89e3\u6a21\u5f0f\u3002\u8fd9\u5bf9\u6df1\u5165\u7814\u7a76CRISPR-Cas\u7cfb\u7edf\u7684\u5206\u5b50\u673a\u5236\u6709\u7740\u91cd\u8981\u7684\u610f\u4e49\u3002<\/span><\/p>\n

\u6b64\u9879\u5de5\u4f5c\u901a\u8fc7\u51b7\u51bb\u7535\u955c\u89e3\u6790\u4e86Type I-E Cascade\/R-loop\/Cas3\u590d\u5408\u4f53\u7684\u6676\u4f53\u7ed3\u6784\uff0c\u6df1\u5165\u7814\u7a76\u4e86Type I-E CRISPR-Cas\u7cfb\u7edf\u4e2dcrRNA\u5f15\u5bfc\u7684DNA\u964d\u89e3\u7684\u5177\u4f53\u751f\u7269\u5b66\u8fc7\u7a0b\u3002\u636e\u6089\uff0c\u8096\u6613\u500d\u6559\u6388\u65e9\u524d\u5728Ailong Ke\u6559\u6388\u8bfe\u9898\u7ec4\u8fdb\u884c\u535a\u58eb\u540e\u7814\u7a76\uff0c\u4ee5\u7b2c\u4e00\u4f5c\u8005\u8eab\u4efd\u5728Nature\u3001Cell\u53d1\u8868\u7814\u7a76\u6027\u8bba\u6587\u5404\u4e00\u7bc7\uff0c\u6b64\u6b21\u5728Science\u53d1\u6587\uff0c\u4e5f\u5b9e\u73b0\u4e86\u201c<\/span><\/span>CNS\u6b63\u520a\u5927\u6ee1\u8d2f<\/strong><\/span>\u201d\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n

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J Control Release | \u59dc\u864e\u6797\u3001\u5362\u5a1c\u5408\u4f5c\u62a5\u9053\u80bf\u7624\u7279\u5f02\u6027\u81ea\u964d\u89e3\u7eb3\u7c73\u524d\u836f\u7528\u4e8e\u63d0\u9ad8\u82ef\u4e01\u9178\u6c2e\u82a5\u7597\u6548<\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u8fd1\u65e5\uff0c\u836f\u5242\u5b66\u9886\u57df\u6743\u5a01\u6742\u5fd7Journalof Controlled Release (\u5f71\u54cd\u56e0\u5b50\uff1a7.786)\u53d1\u8868\u4e86\u59dc\u864e\u6797\u6559\u6388\u548c\u5362\u5a1c\u6559\u6388\u7684\u7684\u6700\u65b0\u5408\u4f5c\u7814\u7a76\u6210\u679c\u2014\u2014Reactive oxygen species-responsive nanoprodrug with quinone methides mediated GSH depletion for improved chlorambucil breast cancers therapy\u3002\u59dc\u864e\u6797\u6559\u6388\u548c\u5362\u5a1c\u6559\u6388\u4e3a\u672c\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/span>
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\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/p>\n


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\u82ef\u4e01\u9178\u6c2e\u82a5\uff08CHL\uff09\u662f\u4e00\u79cd\u751f\u7269\u70f7\u5316\u5242\uff0c\u5728\u4e34\u5e8a\u4e0a\u8f83\u4e3a\u5e7f\u6cdb\u5e94\u7528\u4e8e\u80bf\u7624\u7684\u6cbb\u7597\uff0c\u4e3b\u8981\u901a\u8fc7\u5728\u80de\u5185\u5f62\u6210\u5e26\u6b63\u7535\u8377\u7684\u4e59\u70ef\u4e9a\u80fa\u79bb\u5b50\u4f5c\u7528\u4e8e\u7ec6\u80deDNA\uff0c\u4ecb\u5bfc\u80de\u5185\u6c27\u5316\u538b\u529b\u5347\u9ad8\uff0c\u4f46\u5176\u836f\u6548\u7684\u53d1\u6325\u53d7\u5230\u80bf\u7624\u7ec6\u80de\u5185\u8fc7\u8868\u8fbe\u7684GSH\u7684\u9650\u5236\u3002\u672c\u8bfe\u9898\u9996\u5148\u5408\u6210\u4e86\u542b\u90bb\u4e8c\u7f9f\u57fa\u7684\u805a\u4e59\u4e8c\u9187-\u805a\u4e19\u70ef\u9178\u805a\u5408\u7269\uff08PPA\uff09\u4f5c\u4e3a\u805a\u5408\u7269\u9aa8\u67b6\uff0c\u63a5\u7740\u5c06CHL\u901a\u8fc7\u7f9f\u7532\u57fa\u82ef\u787c\u9178\u95f4\u9694\u57fa\u5171\u4ef7\u4fee\u9970\u5728PPA\u4e0a\u5f97\u5230\u7eb3\u7c73\u524d\u836fPPAHC\u3002PPAHC\u7eb3\u7c73\u524d\u836f\u5177\u6709\u8f83\u597d\u7684\u7a33\u5b9a\u6027\u548c\u4fc3\u8fdb\u7ec6\u80de\u6444\u53d6\u7684\u80fd\u529b\u3002\u7531\u4e8e\u80bf\u7624\u7ec6\u80de\u5185\u7684\u9ad8\u6d3b\u6027\u6c27\uff08ROS\uff09\u6c34\u5e73\uff0cPPAHC\u5728\u8fdb\u5165\u7ec6\u80de\u540e\uff0c4-\u7f9f\u7532\u57fa\u82ef\u787c\u9178\u916f\u5728ROS\u523a\u6fc0\u4e0b\u81ea\u964d\u89e3\u65ad\u88c2\uff0c\u91ca\u653e\u539f\u578b\u836f\u7269CHL\u3002\u540c\u65f6\uff0c\u751f\u6210\u4e2d\u95f4\u4f53\u7532\u57fa\u918c\u7528\u4e8e\u8017\u7aed\u80bf\u7624\u7ec6\u80de\u5185\u7684GSH\uff0c\u4ece\u800c\u589e\u5f3aCHL\u7684\u836f\u6548\uff0c\u6709\u6548\u5f15\u8d77\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002\u5728\u4f53\u5185\u5b9e\u9a8c\u4e2d\uff0cPPAHC\u53ef\u4ee5\u663e\u8457\u6291\u5236\u80bf\u7624\u751f\u957f\u5e76\u964d\u4f4e\u6e38\u79bb\u836fCHL\u5bfc\u81f4\u7684\u6bd2\u526f\u4f5c\u7528\u3002<\/span><\/p>\n

\u8fd9\u79cdROS\u54cd\u5e94\u6027CHL\u7eb3\u7c73\u524d\u836f\uff0c\u5177\u6709\u9ad8\u6291\u7624\u3001\u4f4e\u6bd2\u526f\u4f5c\u7528\u7279\u70b9\uff0c\u7ed9\u4e34\u5e8aCHL\u80bf\u7624\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u601d\u8def<\/span>\u3002<\/p>\n<\/section>\n<\/section>\n

\n
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\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/section>\n

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10<\/p>\n<\/section>\n

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J Control Release | \u59dc\u864e\u6797\u3001\u5f20\u671d\u51e4\u5408\u4f5c\u62a5\u9053\u5316\u836f\u4e0e\u57fa\u56e0\u6cbb\u7597\u809d\u7ea4\u7ef4\u5316\u5171\u9012\u9001\u4f53\u7cfb<\/strong><\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/section>\n<\/section>\n
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\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/p>\n

\u8fd1\u65e5\uff0c\u836f\u5242\u5b66\u9886\u57df\u6743\u5a01\u6742\u5fd7Journalof Controlled Release (\u5f71\u54cd\u56e0\u5b50\uff1a7.786)\u53d1\u8868\u4e86\u59dc\u864e\u6797\u6559\u6388\u548c\u5f20\u671d\u51e4\u526f\u6559\u6388\u7684\u6700\u65b0\u5408\u4f5c\u7814\u7a76\u6210\u679c\u2014\u2014Vitamin A-decorated biocompatible micelles for chemogene therapy of liver fibrosis\u3002\u59dc\u864e\u6797\u6559\u6388\u548c\u5f20\u671d\u51e4\u526f\u6559\u6388\u4e3a\u672c\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/span><\/p>\n

\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"\u3000\u3000\u809d\u7ea4\u7ef4\u5316<\/span>\u662f\u673a\u4f53\u5e94\u5bf9<\/span>\u5404\u79cd\u75c5\u56e0\u6240\u81f4\u6162\u6027\u809d\u635f\u4f24\u7684\u4e00\u79cd\u52a8\u6001\u7684\u4fee\u590d\u53cd\u5e94\uff0c\u5176\u7279\u5f81\u662f\u809d\u661f\u72b6\u7ec6\u80de\uff08HSCs\uff09\u7684\u6d3b\u5316\u5e76\u5f15\u8d77\u80f6\u539f\u7684\u8fc7\u5ea6\u6c89\u79ef\uff0c\u662f\u6162\u6027\u809d\u635f\u4f24\u5230\u809d\u786c\u5316\u7684\u5fc5\u7ecf\u9636\u6bb5\u3002\u672c\u7814\u7a76\u5f00\u53d1\u4e86\u4e00\u79cd\u5b89\u5168\u3001HSCs\u9776\u5411\u7684\u5316\u836f\u4e0e<\/span>\u57fa\u56e0\u5171\u9012\u9001\u7cfb\u7edf\u6cbb\u7597\u809d\u7ea4\u7ef4\u5316\u3002\u4ee5\u751f\u7269\u5185\u6e90\u6027\u5c0f\u5206\u5b50\u7cbe\u80fa\u4e3a\u539f\u6599\uff0c\u5408\u6210\u751f\u7269\u76f8\u5bb9\u6027\u7684\u9633\u79bb\u5b50\u6750\u6599\u805a\u7cbe\u80fa\uff08PSPE\uff09\uff0c\u5e76\u4e0e\u836f\u7528\u8f85\u6599\u805a(\u4e73\u9178\u7f9f\u57fa\u4e59\u9178)\u5171\u805a\u7269\uff08PLGA\uff09\u7f29\u5408\u5236\u5907PLGA-PSPE\uff0c\u5229\u7528\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u4f5c\u4e3a\u4e2d\u95f4\u4f53\u5c06\u5177\u6709HSCs\u9776\u5411\u80fd\u529b\u7684\u7ef4\u751f\u7d20A\uff08VA\uff09\u4e0ePLGA-PSPE\u8fde\u63a5\uff0c\u5236\u5907HSCs\u9776\u5411\u7684PLGA-PSPE-PEG-VA\u6750\u6599\uff0c\u5171\u8f7d\u5316\u836f\u6c34\u98de\u84df\u5bbe\u4e0e\u57fa\u56e0\u836f\u7269siCol1\u03b11\uff0c\u6291\u5236\u80f6\u539f\u5206\u6ccc\uff0c\u6cbb\u7597\u809d\u7ea4\u7ef4\u5316\u3002<\/span><\/p>\n

\u3000\u3000\u5b9e\u9a8c\u8868\u660e\u8be5\u4f53\u7cfb\u5177\u6709\u957f\u5faa\u73af\u80fd\u529b\uff0c\u84c4\u79ef\u4e8e\u809d\u810f\u7ec4\u7ec7\uff0c\u5e76\u88abHSCs\u6709\u6548\u6444\u53d6\uff0c\u663e\u8457\u6291\u5236\u80f6\u539f\u84c4\u79ef\uff0c\u5b9e\u73b0\u809d\u7ea4\u7ef4\u5316\u7684\u9006\u8f6c\uff0c\u4e3a\u4e34\u5e8a\u4e0a\u809d\u7ea4\u7ef4\u5316\u7684\u6cbb\u7597\u63d0\u4f9b\u65b0\u601d\u8def\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n

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\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u5e2e\u63a8\u987b\u77e5<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/section>\n
\n

\u3000\u3000\u300a\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\u300b\u680f\u76ee\u65e8\u5728\u6574\u7406\u836f\u5927\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\u62a5\u9053\u3002\u8bda\u631a\u5e0c\u671b\u5404\u4f4d\u8001\u5e08\u5982\u6709\u65b0\u7684\u4fe1\u606f\u53ef\u4ee5\u4e8e\u6bcf\u6708\u6708\u5e95\u524d\u5c06\u672c\u6708\u7684\u79d1\u7814\u8fdb\u5c55\u53d1\u9001\u81f3\u5b98\u5fae\u90ae\u7bb1cpuweixin@163.com<\/span><\/p>\n<\/section>\n

\n
\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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 \u836f\u5927\u4eba\u90fd\u5728\u770b\uff1a<\/strong>
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\u4e2d\u56fd\u836f\u79d1\u5927\u5b662018\u5e74\u672c\u4e13\u79d1\u4e13\u4e1a\u4ecb\u7ecd<\/a><\/span>
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2018\u6bd5\u4e1a\u5178\u793c\u66a8\u5b66\u4f4d\u6388\u4e88\u4eea\u5f0f | \u94ed\u8bb0\u7f8e\u597d\u82b3\u534e\uff0c\u5954\u5411\u661f\u8fb0\u5927\u6d77<\/span><\/a><\/p>\n

\u62db\u751f\u5b63\uff5c\u4e0e\u4f60\u76f8\u7ea6\uff0c\u836f\u5927\u62db\u751f\u7ec4\u6b63\u5954\u5f80\u5168\u56fd\uff08\u5185\u9644\u6700\u65b0\u62db\u751f\u884c\u7a0b\uff09<\/a><\/span><\/p>\n

2018\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u6c5f\u82cf\u5730\u533a\u4e2d\u5b66\u9a7b\u70b9\u5ba3\u4f20\u4eba\u5458\u8054\u7cfb\u65b9\u5f0f<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\"CPU\u524d\u6cbf\uff5c\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6765\u6e90\uff1aPharmHighlight<\/span><\/p>\n

\u7f16\u8f91\uff1a\u5b54\u90a6\u5f66<\/p>\n

\u8f6c\u81ea\u4e2d\u56fd\u836f\u79d1\u5927\u5b66<\/p>\n

\u5f80\u671f\u7cbe\u5f69<\/span><\/strong><\/p>\n

\u4e00\u81f4\u6027\u8bc4\u4ef7\u76843\u5bb6\u4e0e3\u5e74<\/a><\/span><\/p>\n

\u6c47\u805a\u5357\u836f\u7275\u7ebf\u642d\u6865  \u6821\u4f01\u643a\u624b\u5171\u540c\u63a2\u7d22\u4eba\u624d\u57f9\u517b\u65b0\u6a21\u5f0f\u4e00\u4e00\u9996\u5c4aCRA\u4eba\u624d\u57f9\u8bad\u73ed\u7eaa\u5b9e<\/a><\/p>\n

\u540c\u5fc3\u7b51\u68a6\u2014\u2014\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u4e0a\u6d77\u6821\u53cb\u4f1a\u5e74\u4f1a\u4fa7\u8bb0<\/a><\/p>\n

\u3010\u6848\u4f8b\u8bf4\u3011\u6570\u636e&\u4e34\u5e8a\u4e4b\u771f\u5b9e\u4e16\u754c\u7814\u7a76<\/a><\/span><\/p>\n

\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u6c47\u805a\u5357\u836f <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u680f\u76ee\u4ecb\u7ecd \u3000\u3000\u300a\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\u300b\u4e3b\u8981\u5411\u60a8\u62a5\u9053\u4e0a\u4e00\u4e2a\u6708\u7684\u836f\u5927\u6700\u65b0\u79d1\u7814\u8fdb\u5c55\u3002\u5e0c\u671b\u80fd\u65b9\u4fbf\u5e7f\u5927CPUer\u66f4\u591a\u4e86\u89e3\u836f\u5927\u79d1\u7814 […]<\/p>\n","protected":false},"author":1,"featured_media":3377,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/3376"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=3376"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/3376\/revisions"}],"predecessor-version":[{"id":3419,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/3376\/revisions\/3419"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/3377"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=3376"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=3376"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=3376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}