{"id":34167,"date":"2018-08-06T01:00:00","date_gmt":"2018-08-09T04:34:22","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e8%a1%8c%e4%b8%9a%e9%a3%8e%e5%90%91%e6%a0%87-snp%e6%a0%b7%e6%9c%ac%e8%b7%9f%e8%b8%aa%e6%8e%a2%e9%92%88%ef%bc%8c%e7%bd%97%e6%b0%8f%e5%8f%91%e5%b8%83%e5%85%a8%e6%96%b037mb-prime-exome%e5%85%a8\/"},"modified":"2018-08-09T12:34:28","modified_gmt":"2018-08-09T04:34:28","slug":"%e8%a1%8c%e4%b8%9a%e9%a3%8e%e5%90%91%e6%a0%87-snp%e6%a0%b7%e6%9c%ac%e8%b7%9f%e8%b8%aa%e6%8e%a2%e9%92%88%ef%bc%8c%e7%bd%97%e6%b0%8f%e5%8f%91%e5%b8%83%e5%85%a8%e6%96%b037mb-prime-exome%e5%85%a8","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/34167\/","title":{"rendered":"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"margin: 5px 0.5em 25px;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"           style=\"width: 542px;height: 271px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533789263.jpeg\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><br  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5168\u5916\u663e\u5b50\u6d4b\u5e8f\uff08WES\uff09\u8d70\u5230\u4eca\u5929\u5df2\u7ecf\u670911\u4e2a\u5e74\u5934\u4e86\u3002\u5728\u6d4b\u5e8f\u6210\u672c\u5927\u5e45\u4e0b\u964d\u540e\uff0c\u6709\u89c2\u70b9\u8ba4\u4e3aWES\u5c06\u88abWGS\u9010\u6b65\u66ff\u4ee3\u3002\u4f46\u4e8b\u5b9e\u4e0a\uff0cWES\u4ecd\u7136\u662fNGS\u6280\u672f\u4e2d\u7684\u201cSweet Spot\u201d[1]\u3002WES\u4e3b\u8981\u7531Roche\u548cAgilent\u5171\u540c\u63a8\u52a8\uff0c\u524d\u8005\u57282007\u5e74\u5c06\u56fa\u76f8\u82af\u7247\u9776\u5411\u6355\u83b7\u4e0e\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7ed3\u5408\u8d77\u6765[2]\uff0c\u5f00\u521b\u4e86\u5916\u663e\u5b50\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7684\u65b0\u7eaa\u5143\uff0c\u540e\u8005\u57282009\u5e74\u5f00\u53d1\u7684\u6db2\u76f8\u63a2\u9488\u6781\u5927\u7684\u7b80\u5316\u4e86\u5b9e\u9a8c\u6d41\u7a0b[3]\uff0c\u4f7f\u5f97WES\u7684\u89c4\u6a21\u5316\u3001\u81ea\u52a8\u5316\u6210\u4e3a\u53ef\u80fd\uff08\u56fe1\uff09\u3002&nbsp;<\/span><br  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533789264.jpg\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u56fe1. \u57fa\u4e8e\u6742\u4ea4\u6355\u83b7\u539f\u7406\u7684\u4e24\u79cd\u9776\u5411\u9ad8\u901a\u91cf\u6d4b\u5e8f\u6280\u672f\uff0c\u9700\u8981\u201c\u91cd\u578b\u201d\u8bbe\u5907\u7684\u56fa\u76f8\u82af\u7247\uff08\u5de6\uff09\u548c\u8f7b\u4fbf\u7684\u6db2\u76f8\u63a2\u9488\uff08\u53f3\uff09[4]<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5728\u5927\u91cf\u6570\u636e\u79ef\u7d2f\u540e\uff0cWES\u6355\u83b7\u533a\u57df\u7684\u8bbe\u8ba1\u66f4\u52a0\u201c\u7cbe\u534e\u201d\u3002\u7531\u4e8e\u5927\u90e8\u5206\u81f4\u75c5\u7a81\u53d8\u4f4d\u4e8e\u86cb\u767d\u7f16\u7801\u533a\uff08CCDS\uff09\uff0cIDT\u4e8e2014\u5e74\u53d1\u5e03\u4e86\u7ecf\u6d4e\u578b39Mb CCDS WES\u63a2\u9488\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u6839\u636e\u7ecf\u8d39\u60c5\u51b5\u66f4\u52a0\u7075\u6d3b\u5730\u786e\u5b9a\u7814\u7a76\u6837\u672c\u6570\u91cf\u3002\u4e0d\u8fc7\u5c31\u50cf\u5f53\u5e74\u7684\u4e2d\u5173\u6751\u7ec4\u88c5\u7535\u8111\u4e00\u6837\uff0c\u7531\u4e8e\u53ea\u63d0\u4f9b\u63a2\u9488\uff0cIDT WES\u4e5f\u8fdb\u5165\u4e86\u201c\u7ec4\u88c5\u65f6\u4ee3\u201d\uff0c\u6280\u672f\u4eba\u5458\u9700\u8981\u81ea\u884c\u91c7\u8d2d\u9884\u6587\u5e93\u6784\u5efa\u8bd5\u5242\u76d2\u3001\u94fe\u9709\u4eb2\u548c\u7d20\u78c1\u73e0\u7b49\u5176\u4ed6\u8f85\u52a9\u8bd5\u5242\uff0c\u7a0d\u663e\u7e41\u7410\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u7f57\u6c0f\u6355\u83b7\u4e00\u76f4\u81f4\u529b\u4e8e\u63a8\u52a8NGS\u7684\u4e34\u5e8a\u5e94\u7528\u3002\u65e9\u57282013\u5e74\uff0c\u8d1d\u52d2\u533b\u5b66\u9662\u5c31\u91c7\u7528\u7f57\u6c0f HGSC VCRome\u5bf9250\u4e2a\u5148\u5929\u6027\u53d1\u80b2\u5f02\u5e38\u7684\u513f\u7ae5\u8fdb\u884cWES\u6d4b\u5e8f\uff0c\u68c0\u51fa\u7387\u4e3a25%\uff0c<strong>\u9996\u6b21\u5411\u4eba\u4eec\u5c55\u793a\u4e86WES\u5728\u9057\u4f20\u75c5\u4e34\u5e8a\u8bca\u65ad\u4e2d\u7684\u5f3a\u5927\u6f5c\u529b<\/strong>\u3002\u968f\u540e\uff0c\u7814\u7a76\u8005\u53c8\u4f7f\u7528VCRome\u5bf9&nbsp;2000\u4f8b\u75c5\u4f8b\u8fdb\u884c\u4e86\u5206\u6790\uff0c\u4e3aWES\u8d70\u8fdb\u4e34\u5e8a\u63d0\u4f9b\u4e86\u5927\u91cf\u4e00\u7ebf\u6570\u636e[5\uff0c6]\u3002\u73b0\u5728\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u6570\u636e\u8868\u660e\uff0cWES\u53ef\u4ee5\u4e3a\u9057\u4f20\u75c5\u60a3\u8005\u5e26\u53bb\u66f4\u4f18\u7684\u533b\u5b66\u51b3\u7b56[7]\u30022017\u5e74\uff0c\u7f57\u6c0f\u6355\u83b7\u6280\u672f\u53c8\u52a9\u529b\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u7684MSKCC-IMPACT Panel\u6210\u4e3aFDA\u9996\u4e2a\u6279\u51c6\u7684\u80bf\u7624\u591a\u57fa\u56e0\u68c0\u6d4b\u8bd5\u5242\u76d2[9]\u3002&nbsp;<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533789264.jpg\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u56fe2. WES\u5e94\u7528\u4e8e\u9057\u4f20\u75c5\u81f4\u75c5\u57fa\u56e0\u9274\u5b9a[8]<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u53ef\u4ee5\u9884\u89c1\uff0cNGS\u6280\u672f\u5c06\u4f1a\u8d8a\u6765\u8d8a\u5e7f\u6cdb\u548c\u6df1\u5165\u7684\u5e94\u7528\u4e8e\u4e34\u5e8a\u8bca\u65ad\uff0c\u5305\u62ec\u9057\u4f20\u75c5\u8f85\u52a9\u8bca\u65ad\u3001\u764c\u75c7\u4f34\u968f\u8bca\u65ad\u3001\u5355\u57fa\u56e0\u75c5\u65e0\u521b\u4ea7\u524d\u8bca\u65ad\u7b49\u9886\u57df\u3002\u4f5c\u4e3a\u4e00\u9879\u65b0\u5174\u7684\u5206\u5b50\u68c0\u6d4b\u6280\u672f\uff0c\u76ee\u524d\u7684NGS\u68c0\u6d4b\u6d41\u7a0b\u957f\u4e14\u590d\u6742\uff0c<strong>\u5982\u4f55\u5efa\u7acb\u6709\u6548\u7684\u6837\u672c\u8ddf\u8e2a\u3001\u6c61\u67d3\u76d1\u6d4b\u7b49\u8d28\u91cf\u63a7\u5236\u4f53\u7cfb\u662f\u672a\u6765NGS\u5927\u89c4\u6a21\u5e94\u7528\u9996\u5148\u9700\u8981\u8003\u8651\u7684\u95ee\u9898\u3002<\/strong><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533789264-1.jpg\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u56fe3. \u201c\u6f2b\u957f\u201d\u7684NGS\u764c\u75c7\u57fa\u56e0\u68c0\u6d4b\u6d41\u7a0b[9]<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5728\u8fd9\u6837\u7684\u5927\u80cc\u666f\u4e0b\uff0c<strong>\u7f57\u6c0f\u63a8\u51fa\u4e86\u884c\u4e1a\u5185\u9996\u6b3e\u5177\u6709\u6837\u672c\u8ddf\u8e2a\u3001\u9274\u522b\u529f\u80fd\u7684\u5168\u5916\u663e\u5b50\u6d4b\u5e8f\u4ea7\u54c1SeqCap EZ Prime Exome\uff0c\u4e3a\u5efa\u7acb\u7cfb\u7edf\u7684NGS\u884c\u4e1a\u89c4\u8303\u8fc8\u51fa\u4e86\u91cd\u8981\u4e00\u6b65\u3002<\/strong>\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u5c06\u4e3a\u5927\u5bb6\u8be6\u7ec6\u4ecb\u7ecd\u7f57\u6c0f\u8fd9\u6b3e\u5f15\u9886\u884c\u4e1a\u6807\u51c6\u7684\u5168\u5916\u663e\u5b50\u4ea7\u54c1\u3002<\/span><\/p>\n<section style=\"white-space: normal;box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 21.6146px;box-sizing: border-box;overflow: hidden !important;\"><img     style=\"vertical-align: middle;width: 21.6146px;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533789264.png\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/section>\n<section class=\"\" style=\"margin: 0.9em 2px 0.6em;padding-top: 2px;padding-bottom: 2px;display: inline-block;vertical-align: middle;border-top: 1px dashed rgb(62, 62, 62);border-bottom: 1px dashed rgb(62, 62, 62);border-right-color: rgb(62, 62, 62);border-left-color: rgb(62, 62, 62);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">&nbsp; &nbsp; &nbsp;<span style=\"color: rgb(0, 66, 121);font-weight: bold;font-size: 18px;\">\u9ad8\u6027\u4ef7\u6bd4&nbsp; &nbsp; &nbsp;<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: bottom;width: 21.6146px;box-sizing: border-box;overflow: hidden !important;\"><img     style=\"vertical-align: middle;width: 21.6146px;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533789265.png\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;\">Prime Exome \u7684\u6355\u83b7\u533a\u57df\u5927\u5c0f\u4e3a37 Mb\uff0c\u5c5e\u4e8e\u201c\u7cbe\u534e\u7248\u201d\uff0c\u5b83\u57fa\u4e8eGRCh38\/hg38\u4eba\u7c7b\u53c2\u8003\u57fa\u56e0\u7ec4\u5e76\u53c2\u8003\u6700\u65b0\u7684CCDS\u6570\u636e\u5e93<\/span><\/strong><span style=\"font-size: 15px;\">[10]\uff0c\u8986\u76d698.1%\u86cb\u767d\u7f16\u7801\u533a\u57df\u3002\u4e0e\u7ade\u54c1\u76f8\u6bd4\uff0c\u5373\u4f7f\u4f7f\u7528\u66f4\u5c11\u7684\u6d4b\u5e8f\u6570\u636e\u91cf\uff0cPrime Exome\u5bf9ACMG\u3001ClinVar\u7b49\u533b\u5b66\u4e34\u5e8a\u6570\u636e\u5e93\u7684\u8986\u76d6\u4e5f\u53ea\u591a\u4e0d\u5c11\u3002\u518d\u52a0\u4e0a\u5728On-target\uff08\u7279\u5f02\u6027\uff09\u548c\u8986\u76d6\u5747\u4e00\u6027\u65b9\u9762\u7684\u4f18\u52bf\uff0c<strong>Prime Exome\u80fd\u4f7f\u6d4b\u5e8f\u8d39\u7528\u964d\u4f4e\u8fd130%<\/strong>\u3002\u7b80\u800c\u8a00\u4e4b\uff0cPrime Exome\u7684\u6027\u4ef7\u6bd4\u66f4\u9ad8\u3002&nbsp;<\/span><br  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533789265.jpg\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><span style=\"color: rgb(136, 136, 136);font-size: 14px;\">\u56fe4. SeqCap EZ Prime Exome\u53ef\u4ee5\u82b1\u8d39\u66f4\u5c11\u7684\u6570\u636e\u91cf\u5e76\u83b7\u5f97\u66f4\u9ad8\u7684\u8986\u76d6\u3002\u4f7f\u7528\u76f8\u540c\u7684Coriell DNA\uff0c\u5229\u7528&nbsp;SeqCap EZ Prime Exome\u4e0e\u7ade\u54c1\u7684WES Panel\u8fdb\u884c\u6355\u83b7\uff0c\u7136\u540e\u5728Illumina Hiseq2500\u6d4b\u5e8f\u4eea\u4e0a\u5206\u522b\u6d4b\u5e8f20M\u548c27.5M reads\uff08100PE\uff09\u3002<\/span><\/p>\n<section style=\"white-space: normal;box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 21.6146px;box-sizing: border-box;overflow: hidden !important;\"><img     style=\"vertical-align: middle;width: 21.6146px;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533789265.png\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/section>\n<section class=\"\" style=\"margin: 0.9em 2px 0.6em;padding-top: 2px;padding-bottom: 2px;display: inline-block;vertical-align: middle;border-top: 1px dashed rgb(62, 62, 62);border-bottom: 1px dashed rgb(62, 62, 62);border-right-color: rgb(62, 62, 62);border-left-color: rgb(62, 62, 62);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">&nbsp; &nbsp; &nbsp;<span style=\"color: rgb(0, 66, 121);font-weight: bold;font-size: 18px;\">\u6570\u636e\u8868\u73b0\u5353\u8d8a&nbsp; &nbsp; &nbsp;<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: bottom;width: 21.6146px;box-sizing: border-box;overflow: hidden !important;\"><img     style=\"vertical-align: middle;width: 21.6146px;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress2-1533789265.png\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5982\u56fe5\u6240\u793a\uff0c\u4ece\u7f57\u6c0f\u53d1\u5e03\u7684\u6d4b\u8bd5\u6570\u636e\u6765\u770b\uff0c<strong>100ng\u8d77\u59cb\uff0c<\/strong><\/span><strong><span style=\"font-size: 15px;\">\u5728\u6d4b\u5e8f4Gb\u65f6\u3001~4%\u7684\u5197\u4f59\u5ea6\u3001\uff5e70%\u7684On-target \uff08\u7279\u5f02\u6027\uff09\u548c96.3%\u7684Target\u533a\u57df\u53ef\u8fbe\u523020x\u4ee5\u4e0a\u7684\u6df1\u5ea6\uff08\u5747\u4e00\u6027\uff09\uff0cPrime Exome\u6570\u636e\u8868\u73b0\u4f18\u5f02<\/span><\/strong><span style=\"font-size: 15px;\">\uff0c\u7b26\u5408\u7f57\u6c0f\u6355\u83b7\u4ea7\u54c1\u7684\u4e00\u8d2f\u8868\u73b0\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533789265.jpg\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><span style=\"font-size: 15px;text-align: justify;\">&nbsp;<\/span><span style=\"color: rgb(136, 136, 136);font-size: 14px;\">\u56fe5. \u7f57\u6c0f SeqCap EZ Prime Exome \u5168\u5916\u663e\u5b50\u6d4b\u5e8f\u8868\u73b0\uff0820M Reads100PE4Gb\uff09<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5353\u8d8a\u7684On-target\u548c\u8986\u76d6\u5747\u5300\u6027\u4e00\u76f4\u4ee5\u6765\u90fd\u662f\u7f57\u6c0f\u6355\u83b7\u4ea7\u54c1\u7684\u6807\u7b7e\uff08\u56fe6A\uff09\uff0c\u6700\u76f4\u63a5\u7684\u597d\u5904\u662f<strong>\u4e0d\u7528\u52a0\u6d4b\u6765\u201c\u5c06\u5c31\u201d\u90a3\u4e9b\u6df1\u5ea6\u4e0d\u591f\u7684\u533a\u57df\uff0c<\/strong><strong>\u53ef\u8282\u7701\u6570\u636e\u91cf<\/strong>\u3002Prime Exome\u4f18\u79c0\u7684\u6570\u636e\u8868\u73b0\u5f97\u76ca\u4e8e\u5176\u7cfb\u7edf\u7684\u63a2\u9488\u8bbe\u8ba1\uff0c\u6bd4\u5982\uff0c\u9ad8\u6d53\u5ea6\u63a2\u9488\u3001\u8d85\u591a\u91cd\u53e0\u74e6\uff08\u56fe6B\uff09\u3001\u72ec\u7279\u7684\u91cd\u590d\u533a\u63a2\u9488\u8bbe\u8ba1\u7b97\u6cd5\u4ee5\u53ca\u7cbe\u96d5\u7ec6\u7422\u7684\u63a2\u9488\u914d\u6bd4\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c<strong>Prime Exome\u8fd8\u5e94\u7528\u4e86\u6700\u65b0\u7684\u63a2\u9488\u5236\u9020\u5de5\u827a\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u4e86\u5176\u5728\u9ad8GC\u533a\u57df\u7684\u8986\u76d6<\/strong>\uff08\u56fe6C\uff09\u3002&nbsp;<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533789265.jpg\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u56fe6. A: \u7f57\u6c0f WES\u8986\u76d6\u5747\u4e00\u6027\u4e00\u76f4\u5904\u4e8e\u884c\u4e1a\u9886\u5148\u6c34\u5e73[11]\uff1bB\uff1a\u8d85\u591a\u91cd\u53e0\u74e6\u63a2\u9488\u8bbe\u8ba1[11]\uff1bC\uff1a\u5168\u65b0\u7684Prime\u63a2\u9488\u5de5\u827a\u660e\u663e\u6539\u5584\u9ad8GC\u533a\u57df\u8986\u76d6[12]<\/span><\/p>\n<section style=\"white-space: normal;box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 21.6146px;box-sizing: border-box;overflow: hidden !important;\"><img     style=\"vertical-align: middle;width: 21.6146px;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress2-1533789266.png\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/section>\n<section class=\"\" style=\"margin: 0.9em 2px 0.6em;padding-top: 2px;padding-bottom: 2px;display: inline-block;vertical-align: middle;border-top: 1px dashed rgb(62, 62, 62);border-bottom: 1px dashed rgb(62, 62, 62);border-right-color: rgb(62, 62, 62);border-left-color: rgb(62, 62, 62);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">&nbsp; &nbsp; &nbsp;<span style=\"color: rgb(0, 66, 121);font-weight: bold;font-size: 18px;\">SNP\u6837\u672c\u8ddf\u8e2a\u6280\u672f&nbsp; &nbsp; &nbsp;<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: bottom;width: 21.6146px;box-sizing: border-box;overflow: hidden !important;\"><img     style=\"vertical-align: middle;width: 21.6146px;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533789266.png\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u76ee\u524d\u7684NGS\u5b9e\u9a8c\u6d41\u7a0b\u8f83\u4e3a\u590d\u6742\uff08\u56fe3\uff09\uff0c\u4ece\u91c7\u96c6\u6837\u672c\u5230\u51fa\u5177\u7ed3\u679c\u4e4b\u95f4\u53ef\u80fd\u6709\u5341\u51e0\u4e2a\u6b65\u9aa4\uff0c\u6837\u672c\u4e4b\u95f4\u7684\u6c61\u67d3\u3001\u751a\u81f3\u662f\u6df7\u6dc6\u7684\u98ce\u9669\u5927\u5927\u589e\u52a0\u3002\u6709\u6587\u732e\u62a5\u9053\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u81ea\u5df1\u5b9e\u9a8c\u5ba4\u67d0\u4e9b\u6837\u672c\u7684Y\u67d3\u8272\u4f53\u76f8\u5173\u57fa\u56e0\u8868\u8fbe\u5f02\u5e38\uff0c\u63a8\u65ad\u53ef\u80fd\u5b58\u5728\u591a\u4e2a\u6df7\u6dc6\u7684\u6837\u54c1\uff08\u56fe7\u4e0a\uff09\u3002\u800c\u8fd9\u79cd\u73b0\u8c61\u6709\u53ef\u80fd\u662f\u666e\u904d\u5b58\u5728\u7684\uff0c\u6240\u4ee5\uff0c\u4ed6\u4eec\u63a5\u7740\u53c8\u5bf9\u4e00\u4e9b\u516c\u5f00\u53d1\u8868\u7684\u4eba\u7c7b\u57fa\u56e0\u6570\u636e\u8fdb\u884c\u5206\u6790\u540e\u53d1\u73b0\uff0c\u7ea63%\uff0841\/1238\uff09\u7684\u6837\u672c\u88ab\u5f04\u6df7\u4e86\uff0c\u4e2a\u522b\u6570\u636e\u5e93\u4e2d\u5b58\u5728\u6df7\u6dc6\u53ef\u80fd\u6027\u7684\u6837\u672c\u9ad8\u8fbe23%\uff0820\/87\uff09[14]\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u6837\u672c\u95f4\u6c61\u67d3\u95ee\u9898\u4e5f\u6709\u62a5\u9053\uff08\u56fe7\u4e0b\uff09\u3002&nbsp;<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533789266.jpg\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u56fe7. \u4e0a\uff1a\u5229\u7528Y\u67d3\u8272\u4f53\u57fa\u56e0\u8868\u8fbe\u53d1\u73b0\u7684\u591a\u4e2a\u6df7\u6dc6\u6837\u672c[14]\uff1b\u4e0b\uff1a\u5229\u7528SNP\u9274\u5b9a\u6837\u672c\u95f4\u6c61\u67d3\u6bd4\u4f8b[15]<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u4e3a\u907f\u514d\u4ee5\u4e0a\u95ee\u9898\uff0c<strong>\u7f57\u6c0f SeqCap EZ Prime Exome\u5305\u542b\u4e86340\u4e2a\u7cbe\u5fc3\u6311\u9009\u7684SNP\u4f4d\u70b9[13]\uff0c\u8fd9\u4e9bSNP\u4f4d\u70b9\u7ec4\u6210\u4e86\u6e90\u4e8eDNA\u5185\u90e8\u7684\u6837\u672c\u8bc6\u522bID\uff0c\u53ef\u4ee5\u5728\u6574\u4e2a\u68c0\u6d4b\u8fc7\u7a0b\u4e2d\u660e\u786e\u5730\u8ddf\u8e2a\u6bcf\u4e2a\u6837\u672c\uff08\u56fe8\uff09\uff0c\u5e76\u76d1\u6d4b\u6837\u672c\u95f4\u7684\u6c61\u67d3\u60c5\u51b5<\/strong>\u3002\u4e0e\u624b\u52a8\u6dfb\u52a0\u63ba\u5165\u6807\u8bb0\u7269\u6216Index\u6d4b\u5e8f\u6807\u7b7e\u4e0d\u540c\uff0cSNP ID\u53ef\u4ee5\u89c4\u907f\u4eba\u4e3a\u64cd\u4f5c\u5931\u8bef\u7684\u98ce\u9669\u3002&nbsp;<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress2-1533789266.jpg\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u56fe8. \u4f7f\u7528SNP ID\u8ddf\u8e2a\u6837\u672c\u793a\u610f\u56fe[13]<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5982\u56fe9\u6240\u793a\uff0c\u5728\u5bf98\u79cdCoriell DNA\u7684\u6355\u83b7\u6d4b\u8bd5\u4e2d\uff0c&nbsp;Prime Exome\u7684SNP\u63a2\u9488\u8868\u73b0\u4f18\u5f02\uff0c\u5728\u6d4b\u5e8f4Gb\u6570\u636e\u91cf\u65f6\uff0c340\u4e2aSNP\u4f4d\u70b9\u7684\u5e73\u5747\u6df1\u5ea6\u226540x\uff0c\u5176\u4e2d300\u4e2a\u4f4d\u70b9\u7684\u6df1\u5ea6\u90fd\u8fbe\u523020x\u4ee5\u4e0a\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533789267.jpg\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u56fe9. Prime Exome\u4e2dSNP\u63a2\u9488\u6570\u636e\u8868\u73b0\uff0820M Reads100PE4 Gb\uff09<\/span><\/p>\n<section style=\"white-space: normal;box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 21.6146px;box-sizing: border-box;overflow: hidden !important;\"><img     style=\"vertical-align: middle;width: 21.6146px;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533789267.png\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/section>\n<section class=\"\" style=\"margin: 0.9em 2px 0.6em;padding-top: 2px;padding-bottom: 2px;display: inline-block;vertical-align: middle;border-top: 1px dashed rgb(62, 62, 62);border-bottom: 1px dashed rgb(62, 62, 62);border-right-color: rgb(62, 62, 62);border-left-color: rgb(62, 62, 62);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">&nbsp; &nbsp; &nbsp;<span style=\"color: rgb(0, 66, 121);font-weight: bold;font-size: 18px;\">\u7f57\u6c0f\u5916\u663e\u5b50\u5927\u5bb6\u65cf\u4ea7\u54c1\u4e00\u89c8&nbsp; &nbsp; &nbsp;<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: bottom;width: 21.6146px;box-sizing: border-box;overflow: hidden !important;\"><img     style=\"vertical-align: middle;width: 21.6146px;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533789267.png\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5728\u65b0\u6210\u5458Prime Exome\u52a0\u5165\u540e\uff0c\u7f57\u6c0f\u5916\u663e\u5b50Panel\u53d8\u5f97\u66f4\u52a0\u4e30\u5bcc\u3002\u5982\u88681\u6240\u793a\uff0c\u7f57\u6c0f\u5916\u663e\u5b50\u6355\u83b7\u7cfb\u5217\u5305\u62ec\u4e13\u6ce8\u6838\u5fc3\u533a\u57df\u7684Prime Exome\uff0837.1Mb\uff09\u3001\u9002\u5408\u4e34\u5e8a\u533b\u5b66\u7814\u7a76\u7684MedExome\uff0847Mb\uff09\u3001\u6700\u5168\u9762\u7684EZ Exome V3\uff0864Mb\uff09\u3001\u542b\u6709\u4e13\u5c5eUTR\u7684EZ Exome+UTR\uff0896Mb\uff09\uff0c\u9664\u6b64\u4e4b\u5916\u8fd8\u6709\u7ecf,\u8fc7\u5927\u89c4\u6a21\u4e34\u5e8a\u9a8c\u8bc1\u7684HGSC VCRome\uff0845.2Mb\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u7528\u6237\u53ef\u4ee5\u5728MedExome\u548cEZ Exome V3\u7684\u9aa8\u67b6Panel\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u63ba\u5165\u4e2a\u6027\u5316\u9776\u6807\uff0c\u5b9e\u73b0\u7528\u6237\u4ea7\u54c1\u5dee\u5f02\u5316\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;text-align: center;\">\u88681\uff1a\u7f57\u6c0f\u5916\u663e\u5b50\u6355\u83b7\u4ea7\u54c1<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533789267.png\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/p>\n<section style=\"white-space: normal;box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 21.6146px;box-sizing: border-box;overflow: hidden !important;\"><img     style=\"vertical-align: middle;width: 21.6146px;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533789267.png\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/section>\n<section class=\"\" style=\"margin: 0.9em 2px 0.6em;padding-top: 2px;padding-bottom: 2px;display: inline-block;vertical-align: middle;border-top: 1px dashed rgb(62, 62, 62);border-bottom: 1px dashed rgb(62, 62, 62);border-right-color: rgb(62, 62, 62);border-left-color: rgb(62, 62, 62);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">&nbsp; &nbsp; &nbsp;<span style=\"color: rgb(0, 66, 121);font-weight: bold;font-size: 18px;\">\u7ed3 \u8bed&nbsp; &nbsp; &nbsp;<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: bottom;width: 21.6146px;box-sizing: border-box;overflow: hidden !important;\"><img     style=\"vertical-align: middle;width: 21.6146px;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533789267-1.png\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u7efc\u4e0a\uff0c<strong>\u7f57\u6c0f SeqCap EZ Prime Exome\u4e3b\u8981\u6709\u4e24\u4e2a\u65b9\u9762\u7684\u8c03\u6574\uff0c\u7cbe\u7b80\u5168\u5916\u663e\u5b50panel\u51cf\u5c11\u6d4b\u5e8f\u6210\u672c\u3001\u52a0\u5165SNP\u63a2\u9488\u5efa\u7acb\u6837\u672c\u8ddf\u8e2a\u4f53\u7cfb\u3002<\/strong><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u7ecf\u8fc7\u591a\u5e74\u7684\u53d1\u5c55\uff0c\u57fa\u56e0\u7ec4\u7814\u7a76\u5df2\u7ecf\u6162\u6162\u4ece\u72c2\u70ed\u56de\u5f52\u7406\u6027\uff0c\u884c\u4e1a\u4e5f\u9010\u6b65\u627e\u5230\u4e86NGS\u6700\u5177\u6027\u4ef7\u6bd4\u7684\u5e94\u7528\u65b9\u5411\u3002\u7f57\u6c0f 37Mb Prime Exome\u662f\u9057\u4f20\u75c5\u3001\u764c\u75c7\u7b49\u57fa\u56e0\u7ec4\u6570\u636e\u79ef\u7d2f\u5230\u4e00\u5b9a\u9636\u6bb5\u7684\u5fc5\u7136\u4ea7\u7269\uff0c\u4e5f\u662fWES\u4ece\u7814\u7a76\u8d70\u5411\u4e34\u5e8a\u5e94\u7528\u7684\u91cd\u8981\u63a2\u7d22\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u968f\u7740NGS\u5728\u4ea7\u524d\u7b5b\u67e5\u3001\u9057\u4f20\u75c5\u8f85\u52a9\u8bca\u65ad\u4ee5\u53ca\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u7b49\u9886\u57df\u7684\u5e94\u7528\uff0c\u5efa\u7acb\u5168\u9762\u7684\u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\u4ee5\u53ca\u7cfb\u7edf\u7684\u884c\u4e1a\u89c4\u8303\u8feb\u5728\u7709\u776b\u3002NGS\u68c0\u6d4b\u6d41\u7a0b\u8f83\u957f\uff0cDNA\u5206\u5b50\u53c8\u770b\u4e0d\u89c1\uff0c\u6478\u4e0d\u7740\uff0cDNA\u6837\u672c\u201c\u5f20\u51a0\u674e\u6234\u201d\u53ef\u80fd\u4f1a\u5f15\u53d1\u4e25\u91cd\u7684\u533b\u7597\u4e8b\u6545\u3002\u7f57\u6c0f SeqCap EZ Prime Exome\u4e3a\u884c\u4e1a\u63d0\u4f9b\u4e86<strong>\u4e00\u79cd\u5229\u7528\u6837\u672c\u5185\u90e8\u7684SNP\u6807\u5fd7\u7269\u8fdb\u884c\u76d1\u63a7\u7684\u65b9\u6848<\/strong>\uff0c\u5229\u7528\u8fd9\u4e9bSNP ID\uff0c\u6211\u4eec\u53ef\u4ee5\u5efa\u7acb\u7cfb\u7edf\u7684\u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\uff0c\u5305\u62ec\u7cbe\u786e\u8ddf\u8e2a\u53d7\u68c0\u8005\u7684DNA\u6837\u672c\u3001\u76d1\u63a7\u6837\u54c1\u6c61\u67d3\u3001\u660e\u786e\u5bb6\u7cfb\u6210\u5458\u7684\u751f\u7269\u5b66\u9057\u4f20\u5173\u7cfb\u7b49\uff0c\u6709\u671b\u4e3aNGS\u7684\u5927\u89c4\u6a21\u4e34\u5e8a\u5e94\u7528\u63d0\u4f9b\u66f4\u6709\u529b\u7684\u8d28\u91cf\u4fdd\u969c\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u53c2\u8003\u8d44\u6599<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">1.&nbsp;Exome sequencing: the sweet spot before&nbsp;whole genomes. Human Molecular Genetics, 2010&nbsp;<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">2.&nbsp;Microarray-based genomic&nbsp;selection for high&nbsp;throughput&nbsp;resequencing. Nature Methods, 2007<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">3. Solution hybrid selection with ultra-long oligonucleotides&nbsp;for massively parallel targeted sequencing. Nature Biotechnology, 2009<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">4. Target-enrichment strategies for nextgeneration&nbsp;sequencing. Nature Methods, 2010<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">5. Clinical Whole-Exome Sequencing&nbsp;for the Diagnosis of Mendelian Disorders. NEJM, 2013<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">6. Molecular Findings Among Patients Referred&nbsp;for Clinical Whole-Exome Sequencing. JAMA, 2014<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">7. Clinical exome sequencing: results from 2819 samples reflecting 1000 families.&#8221; Eur J Hum Genet\uff0c2017<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">8. Genetic diagnosis by whole exome capture&nbsp;and massively parallel DNA sequencing. PNAS, 2009<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">9. Mutational Landscape of Metastatic Cancer Revealed from Prospective Clinical Sequencing of 10,000 Patients. Nat Med,&nbsp;2017<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">10. Recommendations for reporting of secondary findings in clinical exome and genome&nbsp;sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and&nbsp;Genomics. &nbsp;Genet Med, &nbsp;2017<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">11. Performance comparison of exome DNA sequencing technologies. Nature Biotechnology, 2011<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">12.https:\/\/sequencing.roche.com\/en\/products-solutions\/by-category\/target-enrichment\/hybridization\/seqcap-ez-prime-choice-probes.html<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">13.&nbsp;A SNP profiling panel for sample tracking in whole-exome sequencing studies.<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">Genome Med,&nbsp;2013<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">14. MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects. &nbsp;Bioinformatics, 2011<\/span><\/p>\n<p style=\"margin: 10px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">15. Detecting and Estimating Contamination of Human DNA Samples in Sequencing and Array-Based Genotype Data. The American Journal of Human Genetics, 2012<\/span><\/p>\n<p style=\"margin: 25px 0.5em 15px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><strong style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;image-rendering: -webkit-optimize-contrast;box-sizing: border-box !important;word-wrap: break-word !important;\">\u00b7&nbsp;END&nbsp;\u00b7<\/span><\/strong><\/p>\n<p style=\"margin: 15px 0.5em 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"color: rgb(0, 122, 170);\"><strong style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;image-rendering: -webkit-optimize-contrast;box-sizing: border-box !important;word-wrap: break-word !important;\">\u3010\u63a2\u57fa \u00b7 \u597d\u8bfe\u63a8\u8350\u3011<\/span><\/strong><\/span><\/p>\n<p style=\"margin: 15px 0.5em 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><strong><span style=\"font-size: 14px;\"><span style=\"color: rgb(0, 0, 0);max-width: 100%;image-rendering: -webkit-optimize-contrast;box-sizing: border-box !important;word-wrap: break-word !important;\">\u957f\u6309\u8bc6\u522b\u4e0b\u65b9\u4e8c\u7ef4\u7801\uff0c\u5173\u6ce8\u63a2\u57fa\u516c\u4f17\u53f7\uff0c\u70b9\u51fb\u201c<\/span><span style=\"color: rgb(0, 122, 170);max-width: 100%;image-rendering: -webkit-optimize-contrast;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8bfe\u7a0b\u62a5\u540d<\/span><span style=\"color: rgb(0, 0, 0);max-width: 100%;image-rendering: -webkit-optimize-contrast;box-sizing: border-box !important;word-wrap: break-word !important;\">\u201d\uff0c\u8fdb\u5165\u201c<\/span><span style=\"color: rgb(0, 122, 170);max-width: 100%;image-rendering: -webkit-optimize-contrast;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7f57\u6c0f\u6d4b\u5e8f<\/span><span style=\"color: rgb(0, 0, 0);max-width: 100%;image-rendering: -webkit-optimize-contrast;box-sizing: border-box !important;word-wrap: break-word !important;\">\u201d\uff0c\u5373\u53ef\u62a5\u540d\u514d\u8d39\u89c2\u770b\u89c6\u9891\u3002<\/span><\/span><\/strong><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><br  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533789267.gif\" alt=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\" title=\"\u884c\u4e1a\u98ce\u5411\u6807 | SNP\u6837\u672c\u8ddf\u8e2a\u63a2\u9488\uff0c\u7f57\u6c0f\u53d1\u5e03\u5168\u65b037Mb Prime Exome\u5168\u5916\u663e\u5b50\u4ea7\u54c1\uff01\"  \/><br  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u6d4b\u5e8f\u4e2d\u56fd                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5168\u5916\u663e\u5b50\u6d4b\u5e8f\uff08WES\uff09\u8d70\u5230\u4eca\u5929\u5df2\u7ecf\u670911\u4e2a\u5e74\u5934\u4e86\u3002\u5728\u6d4b\u5e8f\u6210\u672c\u5927\u5e45\u4e0b\u964d\u540e\uff0c\u6709\u89c2\u70b9\u8ba4\u4e3aWES\u5c06\u88abWGS\u9010\u6b65\u66ff\u4ee3\u3002\u4f46 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":34168,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34167"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=34167"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34167\/revisions"}],"predecessor-version":[{"id":34195,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34167\/revisions\/34195"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/34168"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=34167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=34167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=34167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}