{"id":34196,"date":"2018-08-05T01:00:00","date_gmt":"2018-08-09T04:34:30","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e6%b5%8b%e5%ba%8f%e7%99%be%e5%ae%b6%e4%b8%a8%e6%81%92%e7%89%b9%e5%9f%ba%e5%9b%a0%e8%81%94%e5%90%88%e5%88%9b%e5%a7%8b%e4%ba%ba%e9%83%91%e5%ae%97%e7%ab%8b%e5%8d%9a%e5%a3%ab%ef%bc%9a%e8%81%9a%e7%84%a6\/"},"modified":"2018-08-09T12:34:33","modified_gmt":"2018-08-09T04:34:33","slug":"%e6%b5%8b%e5%ba%8f%e7%99%be%e5%ae%b6%e4%b8%a8%e6%81%92%e7%89%b9%e5%9f%ba%e5%9b%a0%e8%81%94%e5%90%88%e5%88%9b%e5%a7%8b%e4%ba%ba%e9%83%91%e5%ae%97%e7%ab%8b%e5%8d%9a%e5%a3%ab%ef%bc%9a%e8%81%9a%e7%84%a6","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/34196\/","title":{"rendered":"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-right: 0%;margin-bottom: 5px;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 95%;vertical-align: top;box-shadow: rgb(185, 185, 185) 1.41421px 1.41421px 6px;padding: 10px 10px 5px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-right: 0%;margin-bottom: 15px;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-shadow: rgb(0, 0, 0) 0px 0px 0px;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533789271-1.jpeg\" alt=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\" title=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin: 5px 0% 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 95%;vertical-align: top;box-shadow: rgb(185, 185, 185) 1.41421px 1.41421px 6px;padding: 10px 10px 15px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: -30px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 50%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-shadow: rgb(0, 0, 0) 0px 0px 0px;width: 95%;box-sizing: border-box;\"><img     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533789272.png\" alt=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\" title=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 50%;box-shadow: rgb(0, 0, 0) 0px 0px 0px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;width: 95%;box-sizing: border-box;\"><img     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533789272.png\" alt=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\" title=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: 50%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: left;margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;padding: 3px 10px;border-width: 1px;border-radius: 3px;border-style: solid;border-color: rgb(62, 62, 62);box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"transform: translate3d(-1px, 0px, 0px);-webkit-transform: translate3d(-1px, 0px, 0px);-moz-transform: translate3d(-1px, 0px, 0px);-o-transform: translate3d(-1px, 0px, 0px);box-sizing: border-box;\">\n<section style=\"font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(214, 168, 65);\"><strong style=\"box-sizing: border-box;\">\u4eba\u7269\u7b80\u4ecb<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 50%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: right;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;color: rgb(214, 168, 65);\">5 August 2018<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 8px 0% 18px;box-sizing: border-box;\">\n<p style=\"border-top: 1px dashed rgb(185, 185, 185);box-sizing: border-box;text-align: left;margin-top: 5px;\"><span style=\"font-size: 14px;text-align: justify;\">\u90d1\u5b97\u7acb\u535a\u58eb\uff0c\u6052\u7279\u57fa\u56e0\u521b\u59cb\u4eba\u4e4b\u4e00\u3001\u9996\u5e2d\u79d1\u5b66\u5bb6\u3002\u90d1\u535a\u58eb\u7cfb\u745e\u5178\u5361\u7f57\u7433\u533b\u5b66\u9662\u535a\u58eb\u3001\u54c8\u4f5b\u533b\u5b66\u9662\/\u9ebb\u7701\u603b\u533b\u9662\u764c\u75c7\u4e2d\u5fc3\u535a\u58eb\u540e\u3002\u5728\u54c8\u4f5b\u9ebb\u7701\u603b\u533b\u9662\u5de5\u4f5c\u671f\u95f4\uff0c\u90d1\u535a\u58eb\u53d1\u660e\u4e86\u951a\u5b9a\u591a\u91cdPCR\u6269\u589e\u6280\u672fAMP\uff08Anchored Multiplex PCR\uff09\u3002\u8be5\u65b9\u6cd5\u5728\u9ebb\u7701\u603b\u533b\u9662\u764c\u75c7\u5206\u5b50\u8bca\u65ad\u4e2d\uff0c\u7ecf\u8fc7\u4e09\u5e74\u65f6\u95f4\u4e0a\u4e07\u4f8b\u7684\u4e34\u5e8a\u5e94\u7528\u9a8c\u8bc1\uff0c\u56e0\u5176\u9ad8\u6548\u7387\u3001\u9ad8\u7075\u654f\u5ea6\u548c\u9ad8\u7279\u5f02\u6027\u7b49\u4f18\u52bf\uff0c\u76ee\u524d\u5df2\u7ecf\u53d6\u4ee3\u9662\u5185\u7684\u5176\u4ed6\u65b9\u6cd5\u6210\u4e3a\u9996\u8981\u7684\u5206\u5b50\u75c5\u7406\u68c0\u6d4b\u65b9\u6cd5\uff0c\u5e76\u57282016\u5e7411\u6708\u4efd\u83b7\u5f97\u4e86\u7f8e\u56fd\u4e13\u5229\u6388\u6743\u30022016\u5e74\u521b\u529e\u6df1\u5733\u6052\u7279\u57fa\u56e0\u540e\uff0c\u53d1\u660e\u4e86\u65b0\u4e00\u4ee3\u68c0\u6d4b\u6280\u672f<span style=\"font-size: 14px;text-align: justify;\">PANO-Seq<\/span><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1;vertical-align: super;text-align: center;font-size: 12px;\">TM<\/span><span style=\"font-size: 14px;text-align: justify;\">\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u968f\u7740\u80bf\u7624\u9886\u57df\u8f6c\u5316\u533b\u5b66\u7814\u7a76\u7684\u8fc5\u731b\u53d1\u5c55\uff0c\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u7684\u7406\u5ff5\u4e0d\u65ad\u6df1\u5165\u4eba\u5fc3\uff0cNGS\u68c0\u6d4b\u6280\u672f\u5728\u80bf\u7624\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u7684\u5e94\u7528\u4e5f\u8d8a\u6765\u8d8a\u5e7f\u6cdb\u3002\u4e00\u65f6\u95f4\uff0c\u5343\u6811\u4e07\u6811\u68a8\u82b1\u5f00\uff0c\u6d89\u8db3NGS\u80bf\u7624\u4e34\u5e8a\u8f85\u52a9\u8bca\u65ad\u4ea7\u4e1a\u7684\u516c\u53f8\u4e0d\u65ad\u6d8c\u73b0\u3002\u5728\u56fd\u5185\u4f17\u591a\u57fa\u56e0\u6d4b\u5e8f\u516c\u53f8\u4e2d\uff0c\u62e5\u6709\u65b0\u4e00\u4ee3\u9ad8\u7075\u654f\u5ea6NGS\u5efa\u5e93\u6280\u672f\u5e73\u53f0\u7684\u6052\u7279\u57fa\u56e0\u8131\u9896\u800c\u51fa\uff0c\u4e3a\u4e1a\u754c\u6240\u77a9\u76ee\u3002<strong>\u4f5c\u4e3a\u4e00\u5bb6\u53d1\u660e<\/strong><strong><span style=\"text-align: justify;\">PANO-Seq<\/span><\/strong><\/span><span style=\"font-size: 12px;\"><strong><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1;vertical-align: super;text-align: center;\">TM<\/span><\/strong><\/span><span style=\"font-size: 15px;\"><strong>\u5168\u666f\u6d4b\u5e8f\u6280\u672f\u7684\u516c\u53f8\uff0c\u6052\u7279\u57fa\u56e0\u7684\u4ea7\u54c1\u4e0d\u4ec5\u5bf9\u57fa\u56e0\u7a81\u53d8\u548c\u62f7\u8d1d\u6570\u53d8\u5f02\u7684\u68c0\u6d4b\u5177\u6709\u66f4\u9ad8\u7075\u654f\u5ea6\uff0c\u800c\u4e14\u5728\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\u65b9\u9762\u5177\u6709\u72ec\u5230\u7684\u4f18\u52bf\u3002\u6052\u7279\u57fa\u56e0\u5bf9NGS\u5728\u80bf\u7624\u4e34\u5e8a\u533b\u7597\u9886\u57df\u7684\u5e94\u7528\u6709\u7740\u600e\u6837\u7684\u7406\u89e3\u548c\u89c4\u5212\uff1f\u5bf9\u6b64\uff0c\u6d4b\u5e8f\u4e2d\u56fd\u4e13\u8bbf\u4e86\u6052\u7279\u57fa\u56e0\u9996\u5e2d\u79d1\u5b66\u5bb6\u90d1\u5b97\u7acb\u535a\u58eb\u3002<\/strong>\u5728\u4e13\u8bbf\u4e2d\uff0c\u90d1\u535a\u58eb\u5411\u6d4b\u5e8f\u4e2d\u56fd\u8be6\u7ec6\u4ecb\u7ecd\u4e86\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\u5728\u80bf\u7624\u8bca\u7597\u4e2d\u7684\u91cd\u8981\u610f\u4e49\uff0cAMP\u548c<\/span><span style=\"text-align: justify;font-size: 15px;\">PANO-Seq<\/span><span style=\"font-size: 15px;\"><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1;vertical-align: super;text-align: center;font-size: 12px;\">TM<\/span>\u6280\u672f\u89e3\u51b3\u7684\u4e34\u5e8a\u95ee\u9898\u548c\u4ea7\u54c1\u52a8\u6001\uff0c\u540c\u65f6\u9488\u5bf9\u80bf\u7624\u65e9\u7b5b\u961f\u5217\u7814\u7a76\u7684\u8bd5\u9a8c\u8bbe\u8ba1\u53d1\u8868\u4e86\u81ea\u5df1\u7684\u770b\u6cd5\uff0c\u4ee5\u4e0b\u4e3a\u91c7\u8bbf\u5b9e\u5f55\u3002<\/span><\/p>\n<section style=\"box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-color: rgb(255, 255, 255);width: 100%;padding: 5px 10px;display: inline-block;text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\"><span style=\"color: rgb(255, 169, 0);\"><strong><span style=\"font-size: 18px;text-align: center;\">\u57fa\u56e0\u878d\u5408\uff1a\u5212\u65f6\u4ee3\u610f\u4e49\u7684<\/span><\/strong><\/span><\/p>\n<\/section>\n<p><img     style=\"margin-top: -1em;float: left;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533789272.png\" alt=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\" title=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\"  \/>&nbsp;<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"font-size: 15px;\">\u6d4b\u5e8f\u4e2d\u56fd\uff1a\u5728\u80bf\u7624\u7684\u8bca\u65ad\u4e0e\u6cbb\u7597\u4e2d\uff0c\u57fa\u56e0\u878d\u5408\u626e\u6f14\u4e86\u600e\u6837\u7684\u89d2\u8272\uff1f<\/span><\/strong><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"font-size: 15px;\">\u90d1\u5b97\u7acb\u535a\u58eb\uff1a<\/span><\/strong><\/span><strong><span style=\"font-size: 15px;\">\u5728\u5f00\u521b\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u65f6\u4ee3\u548c\u5f53\u524d\u80bf\u7624\u9776\u5411\u6cbb\u7597\u7684\u201c\u6a2a\u201d\u5411\u53d1\u5c55\uff08\u5f02\u75c5\u540c\u6cbb\uff09\u4e2d\uff0c\u57fa\u56e0\u878d\u5408\u90fd\u626e\u6f14\u7740\u6253\u5934\u9635\u7684\u89d2\u8272\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u57fa\u56e0\u878d\u5408\u4e5f\u8fd8\u662f\u7535\u5f71\u300a\u6211\u4e0d\u662f\u836f\u795e\u300b\u91cc\u7684\u57fa\u56e0\u4e3b\u89d2\u3002\u300a\u836f\u795e\u300b\u91cc\u7684\u836f\u2014\u683c\u5217\u536b\u2014\u662f\u6cbb\u7597<em>BCR-ABL<\/em>\u57fa\u56e0\u878d\u5408\u5bfc\u81f4\u7684\u6162\u6027\u7c92\u7ec6\u80de\u6027\u767d\u8840\u75c5\u7684\u7279\u6548\u9776\u5411\u836f\u7269\uff0c\u662f\u80bf\u7624\u7cbe\u51c6\u6cbb\u7597\u7684\u7ecf\u5178\u6848\u4f8b\uff1a54\u4f8b\u7ecf\u8fc7\u963f\u6cd5\u5e72\u6270\u7d20\u6cbb\u7597\u5931\u8d25\u7684\u6162\u7c92\u75c5\u4eba\u5728\u63a5\u53d7\u4e86\u683c\u5217\u536b\u6cbb\u7597\u540e\uff0c53\u4f8b\u8840\u6db2\u5b66\u68c0\u67e5\u5b8c\u5168\u56de\u5f52\u6b63\u5e38\uff0c\u8fd9\u4e00\u7ed3\u679c\u662f\u53f2\u65e0\u524d\u4f8b\u7684\uff0c\u7ed3\u679c\u53d1\u8868\u4e8e2001\u5e74\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u6b64\u5916\uff0c\u5728\u4e0a\u6d77\u8840\u7814\u6240\u539f\u6240\u957f\u738b\u632f\u4e49\u6559\u6388\u7684\u5f15\u9886\u4e0b\uff0c\u9648\u7afa\u6559\u6388\u53ca\u5176\u56e2\u961f\u5bf9\u9610\u660e\u6025\u6027\u65e9\u5e7c\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u53d1\u751f\u7684\u5206\u5b50\u673a\u5236\u505a\u51fa\u4e86\u91cd\u5927\u8d21\u732e\uff0c\u5e76\u63a2\u7d22\u9996\u521b\u4e86\u7528\u5168\u53cd\u5f0f\u7ef4\u7532\u9178\u6cbb\u7597\u6025\u6027\u65e9\u5e7c\u7684\u5386\u53f2\u3002\u7ed3\u5408\u5f20\u5ead\u680b\u6559\u6388\u7528\u4fd7\u79f0\u7812\u971c\u7684\u4e09\u6c27\u5316\u4e8c\u7837\u201c\u4ee5\u6bd2\u653b\u6bd2\u201d\u7597\u6cd5\uff0c\u4e0a\u6d77\u8840\u7814\u6240\u57282001-2003\u5e74\u5165\u7ec461\u4f8b\u65b0\u53d1\u6025\u6027\u65e9\u5e7c\u75c5\u4f8b\u7684\u4e34\u5e8a\u5b9e\u9a8c\u4e2d\u8868\u660e\u4e8c\u8005\u7684\u8054\u5408\u6cbb\u7597\u53ef\u4ee5\u6cbb\u6108\u8fd9\u4e2a\u6076\u6027\u5ea6\u6781\u9ad8\u7684\u764c\u75c7\u3002\u6211\u60f3\u5f3a\u8c03\u4e00\u4e0b\uff0c<strong>\u8fd9\u91cc\u7684\u6548\u679c\u662f\u201c\u6cbb\u6108\u201d<\/strong>\uff0c\u4e0d\u50cf\u300a\u836f\u795e\u300b\u91cc\u7684\u8981\u6301\u7eed\u5403\u836f\u3002\u8fd9\u4e2a\u4e34\u5e8a\u5b9e\u9a8c\u7684\u57fa\u56e01\u53f7\u662f<em>PML-RARA<\/em>\u57fa\u56e0\u878d\u5408\uff0c\u6ca1\u6709\u57fa\u56e02\u53f7\u3002\u9648\u7afa\u6559\u6388\u83b7\u5f97\u8fc7\u591a\u9879\u8363\u8a89\uff0c\u5305\u62ec\u4eca\u5e744\u6708\u7531\u745e\u5178\u7687\u5bb6\u79d1\u5b66\u9662\u9881\u53d1\u7684\u820d\u8d1d\u91cc\u5956\uff08The Sj\u00f6berg Prize\uff09\uff0c\u73b0\u5b9e\u7248\u7684\u82f1\u96c4\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u968f\u7740\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u7684\u53d1\u5c55\uff0c\u57fa\u56e0\u878d\u5408\u5728\u80bf\u7624\u4e34\u5e8a\u8bca\u7597\u4e2d\u7684\u5730\u4f4d\u6108\u52a0\u91cd\u8981\u3002\u4ee5\u53d1\u75c5\u7387\u6700\u9ad8\u7684\u80ba\u764c\u4e3a\u4f8b\uff0c\u9664\u4e86<em>EGFR<\/em>\u5916\uff0c\u5df2\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u7684\u6cbb\u7597\u9776\u70b9\u2014<em>ALK<\/em>\u548c<em>ROS1<\/em>\u4e8c\u8005\u90fd\u662f\u57fa\u56e0\u878d\u5408\u53d8\u5f02\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u66f4\u4ee4\u4eba\u632f\u594b\u7684\u662f\uff0c\u4eca\u5e74\u7684\u4e00\u9879\u4e34\u5e8a\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u9488\u5bf917\u79cd\u4e0d\u540c\u80bf\u7624\u7684\u5e7f\u8c31\u6297\u764c\u65b0\u836fLOXO-101\u7684\u6cbb\u7597\u603b\u4f53\u6709\u6548\u7387\u4e3a75\uff05\u3002\u5f02\u75c5\u540c\u6cbb\uff1a\u9a71\u52a8\u80bf\u7624\u751f\u957f\u7684\u57fa\u56e0\u51b3\u5b9a\u6cbb\u7597\u7b56\u7565\uff0c\u4e14\u628a\u5668\u5b98\u548c\u7ec4\u7ec7\u5206\u578b\u5148\u653e\u4e00\u8fb9\uff0c\u8fd9\u91cc\u7684\u57fa\u56e0\u4e3b\u89d2\u662f<em>NTRK1\/2\/3<\/em>\u7684\u57fa\u56e0\u878d\u5408\u3002\u8fd917\u79cd\u80bf\u7624\u5305\u62ec\u816e\u817a\u4e73\u817a\u6837\u5206\u6ccc\u764c\u3001\u5404\u79cd\u8089\u7624\u3001\u5a74\u513f\u7ea4\u7ef4\u8089\u7624\u3001\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u80f0\u817a\u764c\u3001\u7532\u72b6\u817a\u764c\u3001\u80c3\u95f4\u8d28\u7624\u3001\u9611\u5c3e\u764c\u3001\u4e73\u817a\u764c\u3001\u80c6\u7ba1\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u7b49\uff0c\u53ea\u8981\u6709<em>NTRK1\/2\/3<\/em>\u57fa\u56e0\u878d\u5408\uff0c\u5c31\u53ef\u4ee5\u8fdb\u884c\u7cbe\u51c6\u6253\u51fb\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u6240\u4ee5\uff0c\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\u5728\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u65f6\u4ee3\u7684\u91cd\u8981\u6027\u4e0d\u8a00\u800c\u55bb\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"font-size: 15px;\">\u6d4b\u5e8f\u4e2d\u56fd\uff1a\u60a8\u591a\u5e74\u6765\u4e00\u76f4\u805a\u7126\u4e8eNGS\u7684\u4e34\u5e8a\u5e94\u7528\uff0c\u57fa\u56e0\u878d\u5408\u66f4\u662f\u53d7\u5230\u60a8\u7279\u522b\u5173\u6ce8\uff0c\u5728\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\uff0c\u57fa\u56e0\u878d\u5408\u7684\u5b58\u5728\u8303\u56f4\u4e0e\u5f71\u54cd\u662f\u600e\u6837\u7684\uff1f<\/span><\/strong><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"font-size: 15px;\">\u90d1\u5b97\u7acb\u535a\u58eb\uff1a<\/span><\/strong><\/span><span style=\"font-size: 15px;\">\u662f\u7684\uff0c<\/span><span style=\"font-size: 15px;\">\u7279\u522b\u5173\u6ce8\uff0c\u56e0\u4e3a\u5bf9\u57fa\u56e0\u878d\u5408\u7684\u5206\u5b50\u8bca\u65ad\u65b9\u6cd5\u53ca\u751f\u7269\u4fe1\u606f\u7b97\u6cd5\u7684\u5f00\u53d1\u662f\u6211\u535a\u58eb\u540e\u5bfc\u5e08\u4ea4\u7ed9\u6211\u7684\u7b2c\u4e00\u4e2a\u8bfe\u9898\uff0c\u662f\u5f53\u65f6\u533b\u9662\u5728\u80bf\u7624\u5206\u5b50\u8bca\u65ad\u65b9\u9762\u9047\u5230\u7684\u4e00\u4e2a\u96be\u9898\u3002\u5173\u4e8e\u57fa\u56e0\u878d\u5408\u7684\u5b58\u5728\u8303\u56f4\uff0c\u9664\u4e86\u524d\u9762\u63d0\u5230\u7684\u4e00\u4e9b\u5386\u53f2\u53d1\u5c55\u7684\u6545\u4e8b\uff0c\u4e3a\u4e86\u4e86\u89e3\u5176\u53d1\u751f\u7387\uff0c\u6211\u4eec\u5728\u5b8c\u6210\u4e86\u57fa\u56e0\u878d\u5408\u8bca\u65ad\u5e73\u53f0AMP\u7684\u5f00\u53d1\u4e4b\u540e\uff0c\u56de\u987e\u6027\u5730\u5206\u6790\u4e86\u6837\u672c\u5e93\u91cc1500\u591a\u4f8b\u8d28\u91cf\u53c2\u5dee\u4e0d\u9f50\u7684\u3001\u4e0d\u540c\u7ec4\u7ec7\u6765\u6e90\u7684\u80bf\u7624\u77f3\u8721\u6837\u672c(FFPE)\uff0c<strong>\u53d1\u73b0\u5927\u7ea610%\u7684\u80bf\u7624\u5b58\u5728\u57fa\u56e0\u878d\u5408<\/strong>\u3002\u8fd9\u4e2a\u6bd4\u4f8b\u4e0e\u5927\u578b\u80bf\u7624\u7814\u7a76\uff08TCGA\uff0c\u4e3b\u8981\u662f\u9ad8\u8d28\u91cf\u7684\u51b0\u51bb\u6216\u65b0\u9c9c\u7ec4\u7ec7\uff09\u7684\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u53d1\u73b0\u7684\u57fa\u56e0\u878d\u5408\u6bd4\u4f8b\u76f8\u8fd1\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5728\u672a\u7ecf\u9009\u62e9\u7684\u80bf\u7624\u75c5\u4f8b\u4e2d\u5c31\u6709\u5927\u7ea610%\u7684\u57fa\u56e0\u878d\u5408\uff0c\u53ef\u4ee5\u63a8\u65ad\uff0c\u5728\u4e00\u4e9b\u201c\u9009\u62e9\u8fc7\u7684\u201d\u60a3\u8005\u4e2d\uff0c\u57fa\u56e0\u878d\u5408\u7684\u6bd4\u4f8b\u4f1a\u66f4\u9ad8\u3002\u4f8b\u5982\u80ba\u764c\uff0c\u5982\u679c\u5e38\u89c4\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c\u663e\u793a<em>EGFR<\/em>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\uff0c\u8fd9\u65f6\u57fa\u56e0\u878d\u5408\u53d8\u5f02\u7684\u53ef\u80fd\u6027\u5c31\u8981\u9ad8\u4e8e10%\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"font-size: 15px;\">\u6d4b\u5e8f\u4e2d\u56fd\uff1a\u4e34\u5e8a\u5e94\u7528\u7684\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\u6280\u672f\u5e94\u8be5\u5177\u5907\u54ea\u4e9b\u6761\u4ef6\uff1f<\/span><\/strong><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);font-size: 15px;\">\u90d1\u5b97\u7acb\u535a\u58eb\uff1a<\/span><\/strong><\/span><span style=\"font-size: 15px;\">\u4ece<span style=\"font-size: 15px;\">\u60a3\u8005\u548c\u4e34\u5e8a\u533b\u751f\u7684\u89d2\u5ea6\u6765\u8bf4\uff0c\u6700\u8feb\u5207\u7684\u9700\u6c42\u662f\u5982\u4f55\u80fd\u51c6\u786e\u5730\u53d1\u73b0\u80bf\u7624\u7684\u6cbb\u7597\u9776\u70b9\u3002\u5e94\u7528\u4e8e\u4e34\u5e8a\u68c0\u6d4b\u7684\u6280\u672f\u5fc5\u987b\u6709\u9ad8\u7075\u654f\u5ea6\u548c\u7279\u5f02\u5ea6\u3002\u4e34\u5e8a\u4e0a\u6700\u5e38\u89c1\u7684\u6837\u672c\u662f\u7ecf\u798f\u5c14\u9a6c\u6797\u56fa\u5b9a\u7684\u77f3\u8721\u7ec4\u7ec7\u5757\uff0c\u4e5f\u5c31\u662fFFPE\uff0c\u6837\u672c\u7684\u6838\u9178\uff08\u5305\u62ecDNA\u3001RNA\uff09\u542b\u91cf\u4f4e\uff0c\u4e14\u65ad\u88c2\u7684\u6bd4\u8f83\u4e25\u91cd\u3002<strong>\u6211\u8ba4\u4e3a\u4e0d\u4ec5\u662f\u57fa\u56e0\u878d\u5408\u7684\u68c0\u6d4b\uff0c\u6240\u6709\u7684\u57fa\u56e0\u68c0\u6d4b\u6280\u672f\u8981\u5c3d\u529b\u63d0\u9ad8\u5e94\u5bf9\u4e34\u5e8a\u4e0a\u8d28\u91cf\u53c2\u5dee\u4e0d\u9f50\u6837\u672c\u7684\u80fd\u529b\uff0c\u51cf\u5c11\u6f0f\u8bca\u7387\u3002<\/strong>\u5176\u6b21\uff0c\u57fa\u56e0\u68c0\u6d4b\u5c24\u5176\u662f\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\u7684\u6570\u636e\u5206\u6790\u548c\u68c0\u6d4b\u62a5\u544a\u8981\u4e30\u5bcc\u5168\u9762\uff0c\u4e3a\u533b\u751f\u548c\u60a3\u8005\u51b3\u5b9a\u6cbb\u7597\u65b9\u6848\u63d0\u4f9b\u6709\u6307\u5bfc\u610f\u4e49\u7684\u4fe1\u606f\u3002<\/span><\/span><\/p>\n<section style=\"box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-color: rgb(255, 255, 255);width: 100%;padding: 5px 10px;display: inline-block;text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\"><span style=\"color: rgb(255, 169, 0);\"><strong><span style=\"text-align: center;font-size: 18px;\">AMP\u6280\u672f\uff1a\u8d85\u8d8a\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\u201c\u91d1\u6807\u51c6\u201d<\/span><\/strong><\/span><\/p>\n<\/section>\n<p><img     style=\"margin-top: -1em;float: left;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533789272.png\" alt=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\" title=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\"  \/>&nbsp;<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;color: rgb(0, 122, 170);\">\u6d4b\u5e8f\u4e2d\u56fd\uff1a\u60a8\u53d1\u660e\u7684AMP\u6280\u672f\uff0c\u88ab\u4e1a\u5185\u79f0\u8d5e\u4e3a\u7a81\u7834\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\u7684\u201c\u91d1\u6807\u51c6\u201d\uff0c\u60a8\u8ba4\u4e3aAMP\u6280\u672f\u53ef\u4ee5\u4e3a\u80bf\u7624\u8bca\u65ad\u3001\u6cbb\u7597\u89e3\u51b3\u54ea\u4e9b\u95ee\u9898\uff1f<\/span><\/strong><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;color: rgb(0, 122, 170);\">\u90d1\u5b97\u7acb\u535a\u58eb\uff1a<\/span><\/strong><span style=\"font-size: 15px;\">\u4e0d<\/span><span style=\"font-size: 15px;\">\u6562\u8bf4\u662f\u4ec0\u4e48\u7a81\u7834\u91d1\u6807\u51c6\uff0c\u6ca1\u6709\u6700\u597d\uff0c\u53ea\u6709\u66f4\u597d\u3002<strong>\u9996\u5148\uff0cAMP\u6280\u672f\u4ee5\u76ee\u7684\u57fa\u56e0\u4e3a\u9776\u70b9\uff0c\u8fdb\u884c360\u5ea6\u5168\u65b9\u4f4d\u626b\u63cf\uff0c\u53ef\u68c0\u6d4b\u9776\u57fa\u56e0\u4e0e\u4efb\u4f55\u57fa\u56e0\u7684\u878d\u5408\uff0c\u6240\u4ee5\u662f\u79d1\u7814\u5229\u5668\u3002\u7b2c\u4e8c\uff0cAMP\u53ef\u4ee5\u5bf9\u8d28\u91cf\u4f4e\u4e0b\u7684\u6837\u54c1\uff08\u77ed\u81f360\u4e2a\u78b1\u57fa\u7684RNA\uff09\u8fdb\u884c\u68c0\u6d4b\uff0c\u5bf9\u5404\u79cd\u8d28\u91cf\u53c2\u5dee\u4e0d\u9f50\u7684\u6807\u672c\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u6027\uff0c\u9002\u7528\u4e8e\u4e34\u5e8a\u3002\u7b2c\u4e09\uff0cAMP\u4f7f\u7528\u7684\u90fd\u662f\u975e\u5e38\u666e\u901a\u7684\u5206\u5b50\u751f\u7269\u5b66\u8bd5\u5242\uff0c\u539f\u6599\u6210\u672c\u4f4e\u3002<\/strong><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u4e00\u4e2a\u76f8\u5173\u7684\u8bdd\u9898\uff0c<strong>\u7528DNA\u8fd8\u662f\u7528RNA\u6765\u68c0\u6d4b\u57fa\u56e0\u878d\u5408\uff1f<\/strong>\u5176\u5b9e\uff0cAMP\u6280\u672f\u4f7f\u7528RNA\u8fdb\u884c\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\uff0c\u662f\u6709\u591a\u79cd\u539f\u56e0\u7684\uff0c\u53ef\u4ee5\u5bf9\u57fa\u56e0\u878d\u5408\u7684\u7ed3\u679c\u8fdb\u884c\u8d28\u4e0e\u91cf\u7684\u5224\u65ad\u3002\u5728\u80bf\u7624\u7684NGS\u6570\u636e\u91cc\u6709\u65f6\u53ef\u4ee5\u770b\u5230\u5f88\u591a\u7684\u878d\u5408\u7ed3\u679c\uff0c\u5176\u539f\u56e0\u53ef\u80fd\u662f\u80bf\u7624\u7ec6\u80de\u7684\u751f\u7269\u5b66\u884c\u4e3a\uff0c\u4e5f\u53ef\u80fd\u662fNGS\u6587\u5e93\u5236\u5907\u8fc7\u7a0b\u4e2d\u7684\u4eba\u4e3a\u56e0\u7d20\u3002\u867d\u7136\u53d8\u5f02\u53d1\u751f\u5728\u57fa\u56e0\u7ec4DNA\u6c34\u5e73\uff0c\u4f46\u662f\u901a\u8fc7\u7ec6\u80de\u81ea\u8eab\u5bf9preRNA\u7684\u526a\u5207\u8fc7\u7a0b\u53ef\u4ee5\u53bb\u6389\u65e0\u610f\u4e49\u7684\u5e8f\u5217\uff0c\u4e14\u8fd9\u90e8\u5206\u5e8f\u5217\u5f80\u5f80\u5177\u6709\u957f\uff08\u9700\u8981\u7684\u6d4b\u5e8f\u91cf\u5448\u5341\u500d\u3001\u767e\u500d\u5730\u589e\u52a0\uff09\u4e14\u5176\u7279\u5f02\u6027\u4f4e\uff08\u9020\u6210\u4e86\u5728\u6570\u636e\u5206\u6790\u65f6\u4e0e\u57fa\u56e0\u7ec4\u5e8f\u5217\u6bd4\u5bf9\u7684\u4e0d\u786e\u5b9a\u6027\u3001Mapping Quality\u4f4e\uff09\u7684\u7279\u5f81\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;\">\u4eceRNA\u5165\u624b\u68c0\u6d4b\u57fa\u56e0\u878d\u5408\uff0c\u4e0d\u4f46\u514b\u670d\u4e86\u4ee5\u4e0a\u7684\u7f3a\u70b9\uff0c\u8fd8\u53ef\u4ee5\u5bf9\u878d\u5408\u7684\u7ed3\u679c\u662f\u5426\u9020\u6210\u79fb\u7801\u6846\u9519\u4f4d\u8fdb\u884c\u5206\u6790\uff0c\u5e2e\u52a9\u5224\u65ad\u5176\u5bf9\u7ec6\u80de\u529f\u80fd\u7684\u5f71\u54cd\uff0c\u4f7f\u68c0\u6d4b\u7ed3\u679c\u66f4\u6709\u4ef7\u503c\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u9000\u4e00\u6b65\u6765\u8bf4\uff0cAMP\u6280\u672f\u4e5f\u53ef\u4ee5\u5229\u7528DNA\u8fdb\u884c\u878d\u5408\u68c0\u6d4b\uff0c\u4f46\u662f\u4ee5DNA\u4e3a\u57fa\u7840\u7684\u65b9\u6cd5\uff0c\u4e0d\u7ba1\u662fAMP\u8fd8\u662f\u5e38\u89c4\u7684\u6742\u4ea4\u6355\u83b7\u6cd5\uff0c\u53ef\u4ee5\u5bf9\u4ed8\u7b80\u5355\u7684\u57fa\u56e0\u878d\u5408\uff08\u5982\u68c0\u6d4b<em>ALK<\/em>\uff0c\u6d4b\u5e8f\u91cf\u53ea\u662f\u4e0d\u5230\u767e\u500d\u7684\u589e\u52a0\uff0c\u4f46\u56e0\u7701\u53bb\u4e86\u9006\u8f6c\u5f55\u6b65\u9aa4\uff0c\u603b\u4f53\u5c1a\u80fd\u63a5\u53d7\uff09\uff0c\u4f46\u5bf9\u590d\u6742\u7684\u878d\u5408\uff08\u5982<em>ROS1\u3001NTRKs<\/em>\uff0c\u6d4bDNA\u662f\u505a\u767e\u500d\u4ee5\u4e0a\u7684\u65e0\u7528\u529f\uff0c\u4e14\u6570\u636e\u6bd4\u5bf9\u7684\u8d28\u91cf\u4e0d\u80fd\u4fdd\u8bc1\uff09\u5c31\u5f88\u8d39\u52b2\u4e86\uff0c\u6709\u6f0f\u8bca\u95ee\u9898\u6bd4\u8f83\u5927\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;\">\u4e34\u5e8a\u6807\u672c\u8d28\u91cf\u53c2\u5dee\u4e0d\u9f50\uff0cFFPE\u6807\u672c\u4e2d\u7684RNA\u964d\u89e3\u662f\u666e\u904d\u95ee\u9898\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u5f00\u53d1AMP\u7684\u8fc7\u7a0b\u4e2d\uff0c\u6211\u7684\u5bfc\u5e08\u7ed9\u6211\u4e00\u4e9b\u8fdeRT-PCR\uff08\u76ee\u6807\u4ea7\u7269\u662f80bp\u5927\u5c0f\u7684\u7247\u6bb5\uff09\u65b9\u6cd5\u90fd\u5931\u8d25\u7684\u6807\u672c\uff08\u8fd9\u535a\u58eb\u540e\u8fd8\u505a\u5f97\u4e0b\u53bb\u5417\uff1f\uff09\uff0c\u6709\u53ef\u80fd\u662f\u6807\u672c\u8d28\u91cf\u592a\u5dee\uff0c\u6709\u53ef\u80fd\u662f\u65b0\u7684\u672a\u77e5\u7684\u878d\u5408\u4f19\u4f34\u3002\u7531\u4e8eAMP\u53ea\u662f\u5355\u7aef\u951a\u5b9a\uff0c\u53e6\u4e00\u7aef\u662f\u5f00\u653e\u7684\uff0c\u6240\u4ee5\u5bf9\u5373\u4f7f\u662f\u65ad\u88c2\u6bd4\u8f83\u4e25\u91cd\u7684\u5c0f\u7247\u6bb5\u3001\u5373\u4f7f\u662f\u65b0\u7684\u672a\u77e5\u7684\u878d\u5408\u4f19\u4f34\uff0c\u4e5f\u80fd\u6709\u6548\uff08\u7c7b\u6bd4\u6742\u4ea4\u6355\u83b7\uff09\u3001\u4e14\u9ad8\u6548\uff08\u7c7b\u6bd4PCR\uff09\u5730\u5bcc\u96c6\uff0c\u7efc\u5408\u6742\u4ea4\u6355\u83b7\u4e0ePCR\u4e24\u8005\u7684\u4f18\u52bf\uff0c\u63d0\u9ad8\u4e34\u5e8a\u5e94\u7528\u7684\u9002\u7528\u6027\u3002AMP\u7684\u5f00\u53d1\u662f\u5728<em>ALK<\/em>\uff082010\u5e74\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff09\u4e0e<em>ROS1<\/em>\uff082014\u5e74\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff09\u7684\u6545\u4e8b\u4e4b\u95f4\u5b8c\u6210\u7684\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5728\u7f8e\u56fd\u548c\u6cd5\u56fd\u7684\u5176\u5b83\u51e0\u9879\u7814\u7a76\u4e2d\uff0c\u6bd4\u8f83\u4e86\u6570\u79cd\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\u7684\u65b9\u6cd5\uff0c\u5305\u62ec\u6742\u4ea4\u6355\u83b7\u65b9\u6cd5\u3001AmpliSeq\u3001FISH\u6cd5\u3001AMP\u7b49\uff0c\u7ed3\u679c\u8868\u660eAMP\u662f\u8f83\u5176\u5b83\u65b9\u6cd5\u66f4\u7075\u654f\u3001\u53ef\u9760\u7684\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\u65b9\u6cd5\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57282018\u5e74\u7684JTO\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;color: rgb(0, 122, 170);\">\u6d4b\u5e8f\u4e2d\u56fd\uff1aAMP\u6280\u672f\u4ea7\u54c1\u672a\u6765\u4f1a\u6709\u600e\u6837\u7684\u5347\u7ea7\u4f18\u5316\uff1f\u76ee\u524d\u8fd8\u6709\u54ea\u4e9b\u95ee\u9898\u4e9f\u5f85\u89e3\u51b3\uff1f<\/span><\/strong><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;color: rgb(0, 122, 170);\">\u90d1\u5b97\u7acb\u535a\u58eb\uff1a&nbsp;<\/span><\/strong><span style=\"font-size: 15px;\">\u76ee\u524d\uff0c<\/span><strong><span style=\"font-size: 15px;\">\u6052\u7279\u57fa\u56e0\u6839\u636e\u65b0\u4e00\u4ee3\u7684<span style=\"text-align: justify;font-size: 15px;\">PNAO-Seq<\/span><span style=\"text-align: justify;font-family: \u5fae\u8f6f\u96c5\u9ed1;vertical-align: super;font-size: 12px;\">TM<\/span>\u6280\u672f\u5e73\u53f0\uff0c\u6b63\u5728\u8bbe\u8ba1\u4e00\u4e2a\u4ea7\u54c1\u7cfb\u5217\u2014\u878d\u5408+\uff0c\u5982\u80ba\u764c\u7684\u878d\u5408+<\/span><\/strong><span style=\"font-size: 15px;\">\uff08Lung Fusion+\uff09\uff0c\u80fd\u591f\u5b9e\u73b0\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\u5168\u8986\u76d6\uff0c\u5305\u62ec\u80ba\u764c\u4e2d\u610f\u4e49\u660e\u786e\u7684\u57fa\u56e0\u878d\u5408\uff0c\u4ee5\u53ca\u4e00\u4e9b\u6b63\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8fd8\u672a\u88abFDA\u6279\u51c6\u7684\u878d\u5408\uff0c\u540c\u65f6\u517c\u987e\u4e34\u5e8a\u6307\u5bfc\u610f\u4e49\u660e\u786e\u7684SNV\/Indel\u7a81\u53d8\u548c\u62f7\u8d1d\u6570\u53d8\u5f02\u3002\u8fd9\u4e2a\u5168\u666f\u6d4b\u5e8f\u5e73\u53f0\u5728\u8bbe\u8ba1\u4e0a\u662f\u5f00\u653e\u7684\uff1a<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">&#8211;&nbsp;<strong>\u5bf9\u672a\u77e5\u878d\u5408\u57fa\u56e0\u4f19\u4f34\u5f00\u653e\uff1a<\/strong>\u4e0d\u9650\u5b9a\u878d\u5408\u4f19\u4f34\uff0c\u4e0d\u8bbe\u58c1\u5792\uff0c\u51cf\u5c11\u6f0f\u8bca\u7387\uff1b<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">&#8211;&nbsp;<strong>\u5bf9RNA\u548cDNA\u5f00\u653e\uff1a<\/strong>\u63d0\u53d6\u65f6\u6211\u4eec\u8df3\u8fc7\u6e05\u9664DNA\u6216\u6e05\u9664RNA\u7684\u6b65\u9aa4\uff0c\u5bf9\u5176\u533a\u5206\u7684\u5de5\u4f5c\u7559\u7ed9\u6700\u7ec8\u7684\u751f\u7269\u4fe1\u606f\u5b66\u5904\u7406\u3002\u4e00\u6b21\u68c0\u6d4b\uff0c\u5355\u7ba1\u5b8c\u6210\u878d\u5408\u3001\u7a81\u53d8\uff08SNV\/Indel\uff09\u3001\u62f7\u8d1d\u6570\u53d8\u5f02\u3001\u57fa\u56e0\u8868\u8fbe\u8c31\u7684\u68c0\u6d4b\uff1b<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">&#8211;&nbsp;<strong>\u5bf9\u6d4b\u5e8f\u5e73\u53f0\u5f00\u653e<\/strong><strong>\uff1a<\/strong>\u4e0d\u4f46\u517c\u5bb9\u4efb\u4f55\u786c\u4ef6\u6d4b\u5e8f\u4eea\uff0c\u8fd8\u517c\u5bb9\u540c\u4e00\u786c\u4ef6\u5e73\u53f0\u5185\u7684\u5404\u79cd\u578b\u53f7\uff0c\u5982\u517c\u5bb9Illumina\u7684MiSeq\/NextSeq\/HiSeq\u7b49\u5404\u79cd\u4e0d\u540c\u7684\u6d4b\u5e8f\u6d41\u7a0b\uff0c\u4e14\u5bf9\u6709\u4e9b\u6d41\u7a0b\u7684\u8f6f\u4ef6\u5f00\u53d1\u5982\u63d0\u53d6UMI\uff082012\u5e74\uff09\u662f\u8d70\u5728Illumina\u7684\u5b98\u65b9\u8f6f\u4ef6\u4e4b\u524d\u7684\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u9664\u6280\u672f\u548c\u4ea7\u54c1\u7684\u5347\u7ea7\u4f18\u5316\uff0c\u6211\u4eec\u7684\u6280\u672f\u8981\u5f97\u5230\u63a8\u5e7f\u4e5f\u6709\u4e9f\u5f85\u89e3\u51b3\u7684\u95ee\u9898\uff0c\u6211\u5e0c\u671b\u501f\u52a9\u6d4b\u5e8f\u4e2d\u56fd\u5e73\u53f0\u4f20\u9012\u4e00\u4e0b\u6211\u7684\u58f0\u97f3\uff0c<strong>\u5e0c\u671b\u672a\u6765\u7684\u5ba4\u95f4\u8d28\u8bc4\u80fd\u591f\u5c3d\u91cf\u4ece\u4e34\u5e8a\u6837\u54c1\u7684\u53ef\u53ca\u6027\u53ca\u68c0\u6d4b\u9700\u6c42\u51fa\u53d1\uff0c\u4e0d\u65ad\u4e30\u5bcc\u6807\u51c6\u54c1\u6216\u8d28\u8bc4\u6807\u672c\u7684\u591a\u6837\u5316<\/strong>\uff0c\u5305\u62ec\u542b\u6709DNA\u548cRNA\u7684\u8d28\u8bc4\u6807\u672c\u3002<\/span><\/p>\n<section style=\"box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-color: rgb(255, 255, 255);width: 100%;padding: 5px 10px;display: inline-block;text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\"><span style=\"color: rgb(255, 169, 0);\"><strong><span style=\"font-size: 18px;text-align: center;\">\u4ea7\u54c1\u52a8\u6001\uff1a\u57fa\u56e0\u878d\u5408+<\/span><\/strong><\/span><\/p>\n<\/section>\n<p><img     style=\"margin-top: -1em;float: left;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533789272.png\" alt=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\" title=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\"  \/>&nbsp;<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"font-size: 15px;\">\u6d4b\u5e8f\u4e2d\u56fd\uff1a2017\u5e74\u5e95\uff0c\u6052\u7279\u57fa\u56e0\u63a8\u51fa\u4e86\u516c\u53f8\u9996\u4e2a\u80bf\u7624\u57fa\u56e0\u68c0\u6d4bPANO-Seq<strong style=\"text-align: justify;white-space: normal;\"><span style=\"font-size: 15px;\"><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1;vertical-align: super;font-size: 12px;\">TM<\/span><\/span><\/strong>&nbsp;LBC Panel\uff0c\u62e5\u6709\u5f3a\u5927\u7684\u57fa\u56e0\u878d\u5408\u53d8\u5f02\u68c0\u6d4b\u529f\u80fd\uff0c\u76ee\u524d\u8be5\u4ea7\u54c1\u7684\u4e34\u5e8a\u5e94\u7528\u60c5\u51b5\u662f\u600e\u6837\u7684\uff1f\u4eca\u5e74\u662f\u5426\u5c06\u6709\u5176\u4ed6\u4ea7\u54c1\u4e0a\u5e02\uff1f<\/span><\/strong><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);font-size: 15px;\">\u90d1\u5b97\u7acb\u535a\u58eb\uff1a<\/span><\/strong><\/span><strong><span style=\"font-size: 15px;\">\u6052<\/span><span style=\"font-size: 15px;\">\u7279\u57fa\u56e0\u6b63\u5728\u5229\u7528<span style=\"text-align: justify;font-size: 15px;\">PANO-Seq<\/span><span style=\"text-align: justify;font-family: \u5fae\u8f6f\u96c5\u9ed1;vertical-align: super;font-size: 12px;\">TM<\/span>\u5e73\u53f0\u4e0e\u4e00\u5bb6\u77e5\u540d\u4e09\u7532\u80bf\u7624\u533b\u9662\u5408\u4f5c\uff0c\u7814\u7a76\u4e2d\u56fd\u4eba\u7fa4\u57fa\u56e0\u878d\u5408\u7684\u79cd\u7c7b\u4e0e\u9891\u7387\uff0c\u540c\u65f6\u68c0\u6d4bpanel\u4e34\u5e8a\u5e94\u7528\u7684\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u7b49<\/span><\/strong><span style=\"font-size: 15px;\">\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u9664\u4e86\u5e38\u89c1\u7684<em>ALK\u3001ROS1\u3001RET<\/em>\u7b49\u57fa\u56e0\u878d\u5408\u5916\uff0c\u6211\u4eec\u8fd8\u68c0\u6d4b\u5230\u4e86\u4e00\u4e9b\u7f55\u89c1\u7684\u57fa\u56e0\u878d\u5408\u3002\u5176\u4e2d\u67d0\u4e9b\u7f55\u89c1\u878d\u5408\u7f8e\u56fd\u5df2\u6709\u62a5\u9053\uff0c\u800c\u4e14\u643a\u6709\u8fd9\u4e9b\u57fa\u56e0\u878d\u5408\u7684\u60a3\u8005\u5728\u63a5\u53d7\u76f8\u5e94\u9776\u5411\u6cbb\u7597\u4e4b\u540e\uff0c\u80bf\u7624\u660e\u663e\u7f29\u5c0f\uff08<em>JCO Precision Oncology<\/em>, 2017\uff09\u3002\u8fd9\u6070\u597d\u9a8c\u8bc1\u4e86<span style=\"text-align: justify;font-size: 15px;\">PANO-Seq<\/span><span style=\"text-align: justify;font-family: \u5fae\u8f6f\u96c5\u9ed1;vertical-align: super;font-size: 12px;\">TM<\/span>\u7684\u7075\u654f\u6027\uff0c\u5177\u6709\u91cd\u5927\u4e34\u5e8a\u610f\u4e49\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u4eca\u5e74\uff0c\u5c06\u8981\u4e0a\u5e02\u7684\u6709\u9664\u9488\u5bf9\u80ba\u764c\u7684Lung Fusion+\uff0c<\/span><strong><span style=\"font-size: 15px;\">\u6052\u7279\u57fa\u56e0\u8fd8\u5c06\u63a8\u51fa\u9488\u5bf9\u9aa8\u8089\u7624\u548c\u7ec4\u7ec7\u8089\u7624\u7684\u4ea7\u54c1\uff0c\u4ee5\u53ca\u9488\u5bf9\u8840\u6db2\u80bf\u7624\u7684\u4ea7\u54c1\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u8840\u6db2\u80bf\u7624\u548c\u8089\u7624\u4e2d\u7684\u57fa\u56e0\u878d\u5408\u5341\u5206\u591a\u6837\uff0c\u9274\u522b\u8bca\u65ad\u662f\u4e2a\u4e34\u5e8a\u4e0a\u7684\u96be\u9898\uff0c\u4f46\u662f\u9488\u5bf9\u8840\u6db2\u80bf\u7624\u57fa\u56e0\u878d\u5408\u7684\u9776\u5411\u6cbb\u7597\u6548\u679c\u975e\u5e38\u663e\u8457\uff0c\u5982\u4e00\u5f00\u59cb\u63d0\u5230\u5f00\u521b\u80bf\u7624\u9776\u5411\u6cbb\u7597\u65f6\u4ee3\u7684\u7ecf\u5178\u6848\u4f8b\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;color: rgb(0, 122, 170);\">\u6d4b\u5e8f\u4e2d\u56fd\uff1a\u76ee\u524d\u7684\u68c0\u6d4b\u4ea7\u54c1\u90fd\u662f\u9488\u5bf9\u67d0\u4e00\u79cd\u764c\u75c7\uff0c\u6709\u6ca1\u6709\u53ef\u80fd\u8bbe\u8ba1\u4e00\u4e2a\u68c0\u6d4b\u4ea7\u54c1\u53ef\u4ee5\u68c0\u6d4b\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u4e0d\u540c\u57fa\u56e0\u878d\u5408\u5462\uff1f<\/span><\/strong><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;color: rgb(0, 122, 170);\">\u90d1\u5b97\u7acb\u535a\u58eb\uff1a<\/span><\/strong><strong><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;\">\u8fd9\u79cd\u4ea7\u54c1\u8bbe\u8ba1\u5728\u6280\u672f\u4e0a\u53ef\u4ee5\u5b9e\u73b0\uff0c\u4f46\u662f\u4ece\u4e34\u5e8a\u9002\u7528\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u9488\u5bf9\u6027\u7684\u68c0\u6d4bpanel\u66f4\u80fd\u63d0\u9ad8\u4e34\u5e8a\u6548\u7387\u3002<\/span><\/span><\/strong><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;\">\u5b9e\u4f53\u80bf\u7624\u7684\u57fa\u56e0\u878d\u5408\u4e0e\u8840\u6db2\u80bf\u7624\u662f\u5b8c\u5168\u4e0d\u4e00\u6837\u7684\u7a81\u53d8\u8c31\uff1b\u8089\u7624\u4e0e\u5176\u4ed6\u4e0a\u76ae\u6e90\u6027\u80bf\u7624\u7684\u7a81\u53d8\u8c31\u4e5f\u6709\u5f88\u5927\u5dee\u5f02\uff0c\u6240\u4ee5\u5728\u57fa\u56e0\u878d\u5408\u65b9\u9762\uff0c\u9488\u5bf9\u6027\u7684\u4ea7\u54c1\u4f1a\u66f4\u8d34\u8fd1\u4e34\u5e8a\u7684\u5b9e\u9645\u9700\u8981\u3002<\/span><\/span><\/p>\n<section style=\"box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-color: rgb(255, 255, 255);width: 100%;padding: 5px 10px;display: inline-block;text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\"><strong><span style=\"text-align: center;color: rgb(255, 169, 0);font-size: 18px;\">\u80bf\u7624\u65e9\u7b5b\uff1a\u6ca1\u6709\u65f6\u5149\u673a\u5668\uff0c\u7814\u7a76\u8bbe\u8ba1\u614e\u4e4b\u53c8\u614e<\/span><\/strong><\/p>\n<\/section>\n<p><img     style=\"margin-top: -1em;float: left;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533789272-1.png\" alt=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\" title=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\"  \/>&nbsp;<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"font-size: 15px;\">\u6d4b\u5e8f\u4e2d\u56fd\uff1a\u524d\u77bb\u6027\u961f\u5217\u7814\u7a76\u662f\u4e3a\u80bf\u7624\u7684\u9884\u9632\u548c\u65e9\u8bca\u65e9\u6cbb\u670d\u52a1\uff0c\u90a3\u4e48\u5728\u65e9\u7b5b\u7684\u961f\u5217\u7814\u7a76\u4e2d\u9700\u8981\u6ce8\u610f\u54ea\u4e9b\u95ee\u9898\uff1f<\/span><\/strong><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);font-size: 15px;\">\u90d1\u5b97\u7acb\u535a\u58eb\uff1a<\/span><\/strong><\/span><span style=\"font-size: 15px;\">\u5f97\u80bf\u7624\u662f\u8fd0\u6c14\u4e0d\u597d\uff08\u201cbad luck\u201d\uff09\u7684\u7ed3\u679c\uff08Science, 2017\uff09\u2014\u8fd9\u4e00\u7ed3\u8bba\u5728\u5b66\u672f\u754c\u5f15\u8d77\u4e86\u6fc0\u70c8\u7684\u4e89\u8bba\u3002\u5728\u6211\u770b\u6765\uff0cbad luck\u7406\u8bba\u7684\u8bba\u636e\u662f\u5f88\u4ee4\u4eba\u4fe1\u670d\u7684\uff0c\u7ec6\u80de\u5206\u88c2\u6b21\u6570\u591a\u4e86\uff0c\u51fa\u9519\u7684\u6982\u7387\u5c31\u9ad8\u3002\u4e0d\u80fd\u518d\u751f\u7684\u7ec4\u7ec7\uff0c\u5982\u5fc3\u808c\u7ec6\u80de\u4ece\u751f\u4e0b\u6765\u591a\u5c11\u5c31\u662f\u591a\u5c11\uff0c\u4e0d\u518d\u5206\u88c2\u589e\u503c\uff0c\u6240\u4ee5\u6ca1\u542c\u8bf4\u8fc7\u5fc3\u810f\u764c\u5427\uff08\u6709\u7ae5\u978b\u8bf4\u201c\u751f\u547d\u5728\u4e8e\u8fd0\u52a8\u201d\u3002\u3002\u3002\u5443\uff0c\u597d\u5427\uff09\u3002\u5f53\u7136\uff0c\u73af\u5883\u56e0\u7d20\u4e0d\u53ef\u5ffd\u7565\uff0cbad luck\u8fd9\u9879\u7814\u7a76\u505a\u4e86\u4e2a\u4f30\u8ba1\uff0c\u5927\u69821\/3\u7684\u80bf\u7624\u662f\u73af\u5883\u56e0\u7d20\u53ca\u9057\u4f20\u56e0\u7d20\u5bfc\u81f4\uff0c\u67092\/3\u662fbad luck\u3002\u4e14\u4e0d\u8bba\u8fd9\u4e2a\u6570\u503c\u7684\u51c6\u786e\u6027\uff0c\u80bf\u7624\u7684\u4e8c\u7ea7\u9884\u9632\uff0c\u5373<strong>\u65e9\u671f\u7b5b\u67e5\uff0c\u4ea1\u7f8a\u8865\u7262\uff0c\u4e3a\u65f6\u4e0d\u665a\uff0c\u867d\u7136\u4e0d\u50cf\u6cbb\u7597\u4e2a\u4f53\u90a3\u6837\u628a\u665a\u671f\u75c5\u4eba\u7684\u80bf\u7624\u7f29\u5c0f\u6216\u6d88\u9664\u6765\u7684\u90a3\u4e48\u5f3a\u70c8\u76f4\u63a5\u7684\u611f\u5b98\u523a\u6fc0\u548c\u5174\u594b\uff0c\u4f46\u662f\u5176\u793e\u4f1a\u610f\u4e49\u91cd\u5927<\/strong>\uff0c\u597d\u6bd4\u5982\u4f20\u67d3\u75c5\u9632\u5236\u53ca\u75ab\u82d7\u7684\u5de8\u5927\u6210\u529f\u540e\u9762\u662f\u5f88\u591a\u7684\u65e0\u540d\u82f1\u96c4\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u80bf\u7624\u7684\u65e9\u7b5b\uff0c\u5728\u57fa\u56e0\u68c0\u6d4b\u4e4b\u524d\uff0c\u57fa\u4e8e\u4f20\u7edf\u7684\u68c0\u67e5\u65b9\u6cd5\u6211\u4eec\u5df2\u7ecf\u5b9e\u8df5\u5f88\u591a\u5e74\u4e86\uff0c\u79ef\u7d2f\u4e86\u5b9d\u8d35\u7684\u7ecf\u9a8c\u548c\u6559\u8bad\u3002\u6211\u5e0c\u671b\u6709\u65f6\u95f4\u53ef\u4ee5\u8ddf\u6d4b\u5e8f\u4e2d\u56fd\u6df1\u5165\u63a2\u8ba8\u8fd9\u4e2a\u95ee\u9898\uff0c\u7b80\u8a00\u4e4b\uff0c\u6211\u76f8\u4fe1\u5927\u9c7c\u662f\u5c0f\u9c7c\u957f\u5927\u7684\uff0c\u6211\u4eec\u8981\u5bfb\u627e\u548c\u5e72\u9884\u7684\u662f\u5c0f\u9ca8\u9c7c\u3002\u65f6\u5149\u4e0d\u80fd\u5012\u6d41\uff0c\u4f60\u4e0d\u77e5\u9053\u5f53\u521d\u88ab\u5e72\u9884\u6389\u7684\u662f\u5c0f\u9ca8\u9c7c\u8fd8\u662f\u65e0\u8f9c\u7684\u5c0f\u9c7c\u3002DNA\u53d8\u5f02\u662f\u80bf\u7624\u4e0d\u505c\u5206\u88c2\u589e\u6b96\u7684\u6839\uff0c\u5e94\u6293\u4f4f\u57fa\u56e0\uff0c\u8ba4\u8bc6\u672c\u8d28\u3002\u5b9e\u8df5\u662f\u68c0\u9a8c\u771f\u7406\u7684\u552f\u4e00\u6807\u51c6\uff0c<strong>\u5728\u4eba\u7fa4\u7b5b\u67e5\u6548\u679c\u8bc4\u4f30\u65b9\u9762\uff0c\u6709selection bias\uff08\u9009\u62e9\u504f\u79fb\uff09, lead time bias\uff08\u5148\u5bfc\u65f6\u6bb5\u504f\u79fb\uff09\u7b49\u7b49\u95ee\u9898\u8981\u8003\u8651\u3002<\/strong>\u6052\u7279\u57fa\u56e0\u6b63\u5728\u4e0e\u4e2d\u5c71\u5e02\u56fd\u5bb6\u80bf\u7624\u65e9\u8bca\u65e9\u6cbb\u57fa\u5730\u5408\u4f5c\uff0c\u57fa\u4e8e\u5065\u5168\u7684\u524d\u77bb\u6027\u961f\u5217\u5f00\u5c55\u524d\u671f\u7814\u7a76\u5de5\u4f5c\uff0c\u6211\u5e0c\u671b\u4e0b\u6b21\u53ef\u4ee5\u6709\u66f4\u591a\u7684\u6570\u636e\u8ddf\u6d4b\u5e8f\u4e2d\u56fd\u5206\u4eab\u8ba8\u8bba\uff0c\u8c22\u8c22!<\/span><\/p>\n<section style=\"box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-color: rgb(255, 255, 255);width: 100%;padding: 5px 10px;display: inline-block;text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\"><span style=\"color: rgb(255, 169, 0);\"><strong><span style=\"font-size: 18px;text-align: center;\">\u540e&nbsp;\u8bb0<\/span><\/strong><\/span><\/p>\n<\/section>\n<p>&nbsp;<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;\">\u5c3d\u7ba1\u57fa\u56e0\u878d\u5408\u68c0\u6d4b\u7684\u4e34\u5e8a\u5e94\u7528\u56f0\u96be\u91cd\u91cd\uff0c\u4f46\u968f\u7740\u6280\u672f\u7684\u8fdb\u6b65\u548c\u79d1\u5b66\u5bb6\u7684\u4e0d\u65ad\u52aa\u529b\uff0c\u76f8\u4fe1\u8fd9\u4e9b\u95ee\u9898\u90fd\u4f1a\u4e00\u4e00\u89e3\u51b3\u3002\u90d1\u5b97\u7acb\u535a\u58eb\u7684AMP\u6280\u672f\uff0c\u4e0e\u6052\u7279\u57fa\u56e0\u65b0\u4e00\u4ee3\u7684<span style=\"font-size: 15px;text-align: justify;\">PANO-Seq<\/span><span style=\"text-align: justify;font-family: \u5fae\u8f6f\u96c5\u9ed1;vertical-align: super;font-size: 12px;\">TM<\/span>\u6280\u672f\u548c\u68c0\u6d4b\u4ea7\u54c1\uff0c\u4e3a\u878d\u5408\u57fa\u56e0\u7684\u4e34\u5e8a\u5e94\u7528\u63d0\u4f9b\u4e86\u7cbe\u51c6\u6709\u6548\u7684\u65b9\u6cd5\u3002\u5e0c\u671b\u5728\u4e0d\u8fdc\u7684\u672a\u6765\uff0c\u90d1\u535a\u58eb\u548c\u6052\u7279\u57fa\u56e0\u80fd\u591f\u5e26\u7ed9\u6211\u4eec\u66f4\u591a\u60ca\u559c\uff0c\u8ba9\u6211\u4eec\u62ed\u76ee\u4ee5\u5f85\u3002<\/span><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><strong style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;image-rendering: -webkit-optimize-contrast;box-sizing: border-box !important;word-wrap: break-word !important;\">\u00b7&nbsp;END&nbsp;\u00b7<\/span><\/strong><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533789272.gif\" alt=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\" title=\"\u6d4b\u5e8f\u767e\u5bb6\u4e28\u6052\u7279\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u90d1\u5b97\u7acb\u535a\u58eb\uff1a\u805a\u7126\u57fa\u56e0\u878d\u5408\uff0c\u62d3\u5c55\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u8303\u56f4\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u6d4b\u5e8f\u4e2d\u56fd                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4eba\u7269\u7b80\u4ecb 5 August 2018 \u90d1\u5b97\u7acb\u535a\u58eb\uff0c\u6052\u7279\u57fa\u56e0\u521b\u59cb\u4eba\u4e4b\u4e00\u3001\u9996\u5e2d\u79d1\u5b66\u5bb6\u3002\u90d1\u535a\u58eb\u7cfb\u745e\u5178\u5361\u7f57\u7433\u533b\u5b66\u9662\u535a\u58eb [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":34197,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34196"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=34196"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34196\/revisions"}],"predecessor-version":[{"id":34210,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34196\/revisions\/34210"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/34197"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=34196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=34196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=34196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}