{"id":34211,"date":"2018-08-04T01:00:00","date_gmt":"2018-08-09T04:34:35","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e5%90%8c%e6%97%a5%e4%b8%a4%e7%af%87nature%e9%87%8d%e7%a3%85%e5%8f%91%e5%b8%83%ef%bc%81%e5%8d%95%e7%bb%86%e8%83%9erna%e6%b5%8b%e5%ba%8f%e5%8f%91%e7%8e%b0%e5%85%a8%e6%96%b0%e7%bb%86%e8%83%9e%e7%b1%bb\/"},"modified":"2018-08-09T12:34:38","modified_gmt":"2018-08-09T04:34:38","slug":"%e5%90%8c%e6%97%a5%e4%b8%a4%e7%af%87nature%e9%87%8d%e7%a3%85%e5%8f%91%e5%b8%83%ef%bc%81%e5%8d%95%e7%bb%86%e8%83%9erna%e6%b5%8b%e5%ba%8f%e5%8f%91%e7%8e%b0%e5%85%a8%e6%96%b0%e7%bb%86%e8%83%9e%e7%b1%bb","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/34211\/","title":{"rendered":"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress2-1533789276-1.jpeg\" alt=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\" title=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\"><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u8ba4\u8bc6\u540c\u4e00\u7ec4\u7ec7\u4e2d\u7684\u4e0d\u540c\u7ec6\u80de\uff0c\u4ee5\u53ca\u540c\u4e00\u7ec6\u80de\u4e2d\u4e0d\u540c\u57fa\u56e0\u7684\u8868\u8fbe\u60c5\u51b5\u3002\u6b64\u524d\u79d1\u5b66\u5bb6\u5728\u80ba\u90e8\u8bc6\u522b\u51fa\u7684\u7ec6\u80de\u5171\u670912\u79cd\uff0c2018\u5e747\u670812\u65e5\uff0c\u7f8e\u56fd\u7814\u7a76\u4eba\u5458\u5229\u7528\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u5bf9\u6570\u5343\u4e2a\u5065\u5eb7\u548c\u764c\u53d8\u80ba\u7ec6\u80de\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u62a5\u9053\u4e8652\u79cd\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\uff0c\u53d1\u5e03\u4e86\u7b2c\u4e00\u4e2a\u5b8c\u6574\u7684\u80ba\u80bf\u7624\u7ec6\u80de\u56fe\u8c31\u3002\u80ba\u90e8\u53ca\u5176\u80bf\u7624\u6216\u8bb8\u8fdc\u6bd4\u6211\u4eec\u8ba4\u4e3a\u7684\u8981\u590d\u6742\u7684\u591a\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u4ec5\u4ec5\u4e0d\u5230\u4e00\u4e2a\u6708\uff0c\u4e00\u79cd\u65b0\u80ba\u90e8\u7ec6\u80de\u5c31\u88ab\u53d1\u73b0\uff0c\u8fdb\u4e00\u6b65\u4e30\u5bcc\u4e86\u80ba\u7ec6\u80de\u56fe\u8c31\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;\">2018\u5e748\u67082\u65e5\uff0c\u56fd\u9645\u9876\u7ea7\u5b66\u672f\u671f\u520a<em>Nature<\/em>\u540c\u671f\u53d1\u8868\u4e86\u4e24\u7bc7\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u7684\u76f8\u5173\u7814\u7a76\u6210\u679c\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4e00\u79cd\u65b0\u578b\u7ec6\u80de\u2014\u2014\u201c\u80ba\u79bb\u5b50\u7ec6\u80de\u201d\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u8fd9\u4e24\u9879\u6210\u679c\u7531\u4e24\u4e2a\u72ec\u7acb\u7814\u7a76\u56e2\u961f\u5b8c\u6210\uff0c\u4ed6\u4eec\u5206\u522b\u4f7f\u7528\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6280\u672f\u5206\u6790\u4e86\u5c0f\u9f20\u3001\u4eba\u7c7b\u6c14\u7ba1\u548c\u652f\u6c14\u7ba1\u7ec4\u7ec7\u7ec6\u80de\uff0c\u6df1\u5165\u4e86\u89e3\u4e86\u80ba\u90e8\u7ec6\u80de\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u540c\u65f6\uff0c<strong>\u4ed6\u4eec\u53d1\u73b0\u53d8\u5316\u591a\u7aef\u7684<em>CFTR<\/em>\u57fa\u56e0\u7a81\u53d8\u8868\u8fbe\u5c31\u5728\u8fd9\u79cd\u65b0\u53d1\u73b0\u7684\u7ec6\u80de\u4e2d\u3002<\/strong><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533789277.jpg\" alt=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\" title=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\"><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u80ba\u79bb\u5b50\u7ec6\u80de\uff08\u6a59\u8272\uff09\u5ef6\u4f38\u901a\u8fc7\u5c0f\u9f20\u4e0a\u547c\u5438\u9053\u4e2d\u7684\u90bb\u8fd1\u4e0a\u76ae\u7ec6\u80de\u3002\u7ec6\u80de\u6838\u5448\u9752\u8272\u3002\u56fe\u7247\u6765\u6e90:Montoro et al.\/Nature 2018<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u79d1\u5b66\u5bb6\u4e00\u76f4\u5728\u63a2\u7d22<em>CFTR<\/em>\u57fa\u56e0\u7a81\u53d8\u53ca\u5176\u8868\u8fbe\uff0c\u4f46\u53d1\u75c5\u673a\u7406\u4e00\u76f4\u672a\u5f97\u5230\u5f7b\u5e95\u7684\u7814\u7a76\u3002\u539f\u6765\u662f\u56e0\u4e3aCFTR\u8868\u8fbe\u4ec5\u53d1\u751f\u5728\u5c11\u6570\u7ec6\u80de\u4e2d\uff0c\u800c\u76f4\u5230\u73b0\u5728\u4eba\u4eec\u624d\u53d1\u73b0\u8fd9\u4e9b\u7ec6\u80de\u5b58\u5728\uff01\u85cf\u5f97\u771f\u6df1\u554a!<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><em><strong><span style=\"font-size: 15px;\">CFTR<\/span><\/strong><\/em><strong><span style=\"font-size: 15px;\">\u662f\u4ec0\u4e48\u57fa\u56e0\uff1f<\/span><\/strong><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u56ca\u6ce1\u6027\u7ea4\u7ef4\u5316\u8de8\u819c\u4f20\u5bfc\u57fa\u56e0\uff08Cystic fibrosis transmembrane conductance regulator ,CFTR\uff09\u662f\u4e00\u79cd\u9ad8\u6c34\u5e73\u7a81\u53d8\u57fa\u56e0\uff0c\u5176\u8868\u8fbe\u7684CFTR\u86cb\u767d\u662f\u4e00\u79cd\u6c2f\u79bb\u5b50\u901a\u9053\u86cb\u767d\uff0c\u4e3b\u8981\u8868\u8fbe\u4e8e\u9ecf\u6db2-\u7ea4\u6bdb\u6e05\u9664\u7cfb\u7edf\u7684\u9ecf\u6db2\u817a\u4f53\u4e2d\uff0c\u5206\u5e03\u5728\u547c\u5438\u9053\u8868\u9762\uff0c\u5728\u9ecf\u6db2\u7ea4\u6bdb\u6e05\u9664\u548c\u81ea\u6211\u9632\u5fa1\u65b9\u9762\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/span><span style=\"font-size: 15px;\">\u800cCFTR\u86cb\u767d\u5f02\u5e38\u5f15\u8d77\u7684\u56ca\u6027\u7ea4\u7ef4\u5316\uff0c\u662f\u5728\u90e8\u5206\u4eba\u7fa4\u4e2d\u9ad8\u53d1\u7684\u4e00\u79cd\u9057\u4f20\u6027\u75be\u75c5\uff0c\u5c24\u5176\u662f\u767d\u8272\u4eba\u79cd\uff0c\u7ea6\u534a\u6570\u513f\u7ae5\u60a3\u8005\u4f1a\u56e0\u611f\u67d3\u6216\u5fc3\u80ba\u529f\u80fd\u8870\u7aed\u7b49\u4e25\u91cd\u5e76\u53d1\u75c7\u4e8e10\u5c81\u524d\u6b7b\u4ea1\uff0c\u6d3b\u81f3\u6210\u5e74\u8005\u8f83\u5c11\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533789277.png\" alt=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\" title=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\"><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5728<em>Nature<\/em>\u53d1\u8868\u7684\u7b2c\u4e00\u7bc7\u6587\u7ae0\u4e2d\uff0c\u6765\u81eaBroad\u7814\u7a76\u6240\u548c\u5176\u4ed6\u673a\u6784\u7684\u540c\u4e8b\uff0c\u5bf9\u8fd17500\u4e2a\u5c0f\u9f20\u7684\u6c14\u7ba1\u4e0a\u76ae\u7ec6\u80de\u505a\u4e86\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0c\u5e76\u5728\u4f53\u5185\u8fdb\u884c\u4e86\u7ec6\u80de\u8c31\u7cfb\u8ffd\u8e2a\u5b9e\u9a8c\u3001\u8109\u51b2\u5e8f\u5217\u5206\u6790\u548c\u8c31\u7cfb\u5c42\u6b21\u5206\u6790\uff0c\u4ee5\u53ca\u4e0e\u56ca\u6027\u7ea4\u7ef4\u5316\u7684\u5173\u7cfb\u7814\u7a76\u3002\u5229\u7528\u8fd9\u4e9b\u6570\u636e\u4fe1\u606f\uff0c\u7814\u7a76\u5c0f\u7ec4\u5206\u6790\u4e86\u5c0f\u9f20\u6c14\u9053\u7ec6\u80de\u7c7b\u578b\u8d77\u6e90\u3001\u53d1\u80b2\u8f68\u8ff9\u548c\u76f8\u4e92\u4f5c\u7528\uff0c\u540c\u65f6\u9274\u522b\u4e86\u4ee5\u524d\u672a\u88ab\u53d1\u73b0\u7684\u80ba\u7ec6\u80de\u7c7b\u578b\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u6587\u7ae0\u4e2d\uff0c<strong>\u7814\u7a76\u5c0f\u7ec4\u91cd\u70b9\u63cf\u8ff0\u4e86\u4e00\u79cd\u4ece\u672a\u88ab\u88ab\u62a5\u9053\u8fc7\u7684\u7f55\u89c1\u65b0\u7ec6\u80de\u7c7b\u578b\u2014\u2014Foxi1+\u80ba\u79bb\u5b50\u7ec6\u80de\u3002<\/strong>\u8fd9\u79cd\u7ec6\u80de\u7684\u57fa\u56e0\u8868\u8fbe\u4e0e\u7279\u6b8a\u7684\u79bb\u5b50\u8fd0\u8f93\u8c03\u8282\u7ec6\u80de\u6709\u5173\uff0c\u4ec5\u7ea6\u5360\u5c0f\u9f20\u548c\u4eba\u7c7b\u7ec6\u80de\u603b\u6570\u76841%\uff0c\u7c7b\u4f3c\u4e8e\u9c7c\u7c7b\u548c\u9752\u86d9\u4e2d\u5e38\u89c1\u7684\u8fd0\u8f93\u79bb\u5b50\u7ec6\u80de\u3002\u5728\u9c7c\u7c7b\u4e2d\uff0c\u79bb\u5b50\u7ec6\u80de\u6709\u52a9\u4e8e\u7ef4\u6301\u673a\u4f53\u4e0e\u6c34\u7684\u5e73\u8861\u3002\u800c\u5728\u5c0f\u9f20\u548c\u4eba\u7c7b\u4f53\u5185\uff0c\u8fd9\u79cd\u65b0\u7ec6\u80de\u4f1a\u5728\u7ec4\u7ec7\u548c\u5468\u56f4\u7a7a\u6c14\u4e4b\u95f4\u7684\u4ea4\u754c\u79fb\u52a8\u79bb\u5b50\u3002\u540c\u65f6\uff0c<strong>\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u5728\u7f3a\u5931Foxi1\u8f6c\u5f55\u56e0\u5b50\u7f16\u7801\u57fa\u56e0\u7684\u5c0f\u9f20\u79bb\u5b50\u7ec6\u80de\u4e2d\uff0c\u56ca\u6027\u7ea4\u7ef4\u5316\u57fa\u56e0CFTR\u7684\u8868\u8fbe\u589e\u5f3a\u3002<\/strong><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533789277.jpg\" alt=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\" title=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\"><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u5c0f\u9f20\u6c14\u7ba1\u4e0a\u76ae\u7ec6\u80de\u7684\u5355\u7ec6\u80de\u8868\u8fbe\u56fe\u8c31,\u56fe\u7247\u6765\u6e90\uff1a<em>Nature<\/em><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">Broad\u7814\u7a76\u6240\u4e3b\u4efb\u3001\u4eba\u7c7b\u7ec6\u80de\u56fe\u8c31\u8054\u5408\u4f1a\u4e3b\u5e2dAviv Regev\u8868\u793a\uff0c<strong>\u5229\u7528\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\uff0c\u53ef\u4ee5\u5e2e\u52a9\u7ed8\u5236\u4e0d\u540c\u7ec4\u7ec7\u4e2d\u7684\u7ec6\u80de\u7c7b\u578b\uff0c\u53d1\u73b0\u672a\u77e5\u7684\u3001\u7f55\u89c1\u7684\u65b0\u7ec6\u80de\uff0c\u7ec6\u80de\u4e9a\u578b\u3002<\/strong>\u5728\u7814\u7a76\u4e86\u6570\u5343\u4e2a\u7ec6\u80de\u5e76\u786e\u5b9a\u4e86\u57fa\u56e0\u5728\u7ec6\u80de\u4e2d\u7684\u529f\u80fd\u540e\uff0cBroad\u7814\u7a76\u56e2\u961f\u5229\u7528\u8fd9\u4e9b\u6570\u636e\u4fe1\u606f\u521b\u5efa\u4e86\u4e00\u4e2a\u201c\u7ec6\u80de\u56fe\u8c31\u201d\uff0c\u8be5\u56fe\u8c31\u53ef\u5e2e\u52a9\u786e\u5b9a\u6bcf\u79cd\u7ec6\u80de\u7c7b\u578b\u7684\u4f4d\u7f6e\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u5c06\u590d\u6742\u80ba\u90e8\u75be\u75c5\u76f8\u5173\u57fa\u56e0\u4e0e\u7279\u5b9a\u7ec6\u80de\u8054\u7cfb\u8d77\u6765\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u8f6c\u53d8\u4e86\u5bf9\u80ba\u90e8\u75be\u75c5\u7684\u601d\u8003\u65b9\u5f0f\uff0c\u5982\u56ca\u6027\u7ea4\u7ef4\u5316\u548c\u54ee\u5598\u7b49\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533789277.jpg\" alt=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\" title=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\"><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5728\u7b2c\u4e8c\u7bc7\u62a5\u9053\u4e2d\uff0c\u8bfa\u534e\u751f\u7269\u533b\u5b66\u7814\u7a76\u6240\u9886\u5bfc\u7684\u7814\u7a76\u5c0f\u7ec4\u8fdb\u884c\u4e86\u7c7b\u4f3c\u7684\u7814\u7a76\uff0c\u4ed6\u4eec\u5bf97600\u591a\u4e2a\u5c0f\u9f20\u7684\u6c14\u7ba1\u4e0a\u76ae\u7ec6\u80de\u548c2970\u4e2a\u539f\u4ee3\u4eba\u652f\u6c14\u7ba1\u4e0a\u76ae\u7ec6\u80de\u8fdb\u884c\u4e86\u5355\u7ec6\u80deRNA\u5206\u6790\u3002<strong>\u6709\u8da3\u7684\u662f\uff0c\u8be5\u7814\u7a76\u56e2\u961f\u5728\u5bf9\u80ba\u7ec6\u80de\u8fdb\u884c\u5206\u7c7b\u7684\u8fc7\u7a0b\u4e2d\u53d1\u73b0\u4e86\u4e0e\u4e0a\u8ff0\u62a5\u9053\u76f8\u540c\u7684\u65b0\u578b\u79bb\u5b50\u7ec6\u80de\u3002<\/strong>\u8bfa\u534e\u56e2\u961f\u7814\u7a76\u4eba\u5458\u8868\u793a\uff1a\u201c\u5f53\u4e0d\u540c\u7814\u7a76\u5c0f\u7ec4\u610f\u8bc6\u5230\u6240\u505a\u7814\u7a76\u5de5\u4f5c\u76f8\u4f3c\u65f6\uff0c\u6211\u4eec\u4f1a\u7ed9\u4e88\u65b0\u7ec6\u80de\u7c7b\u578b\u76f8\u540c\u7684\u540d\u79f0\uff0c\u5e76\u540c\u65f6\u51fa\u7248\u6765\u52a0\u5f3a\u7814\u7a76\u7ed3\u679c\u3002\u201d<\/span><\/p>\n<p style=\"text-align: center;\">\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u5c0f\u9f20\u548c\u4eba\u7c7b\u8fd1\u7aef\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u7684\u5355\u7ec6\u80deRNA-seq\u6d41\u7a0b\uff0c\u56fe\u7247\u6765\u6e90\uff1a<em>Nature<\/em><\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u901a\u8fc7\u7ed3\u5408\u7535\u751f\u7406\u3001\u5f71\u50cf\u5b66\u548c\u5176\u4ed6\u6570\u636e\uff0c\u7814\u7a76\u4eba\u5458\u4e0d\u4ec5\u68c0\u6d4b\u4e86\u80ba\u79bb\u5b50\u7ec6\u80de\u4e2dFoxi1\uff0cCFTR\u548c\u6db2\u6ce1\u578bH + -ATPase\u4e9a\u57fa\u7684\u8868\u8fbe\u3002<strong>\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u4e9b\u7535\u79bb\u7ec6\u80de\u9ad8\u6c34\u5e73\u8868\u8fbe\u4e86<em>CFTR<\/em>\u57fa\u56e0\u3002<\/strong>\u7814\u7a76\u4eba\u5458\u7834\u574f\u4e86\u5c0f\u9f20\u80ba\u7535\u79bb\u7ec6\u80de\u7684\u4e00\u4e2a\u5173\u952e\u5206\u5b50\u8fc7\u7a0b\uff0c\u53d1\u73b0\u5c0f\u9f20\u8868\u73b0\u51fa\u56ca\u6027\u7ea4\u7ef4\u5316\u75c7\u72b6\u3002\u8fd9\u4e00\u53d1\u73b0\u53e6\u7814\u7a76\u4eba\u5458\u5f88\u662f\u5403\u60ca\uff0c\u56e0\u4e3a\u6b64\u524d\u7684\u5047\u8bbe\u591a\u8ba4\u4e3a<em>CFTR<\/em>\u57fa\u56e0\u4e3b\u8981\u5728\u7ea4\u6bdb\u7ec6\u80de\u4e2d\u8868\u8fbe\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u7814\u7a76\u4eba\u5458\u8fd8\u786e\u5b9a\u4e86Notch\u4fe1\u53f7\u4f20\u5bfc\u5728\u8be5\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002\u540c\u65f6\uff0c\u8be5\u7814\u7a76\u5c0f\u7ec4\u63cf\u8ff0\u4e86\u8be5\u65b0\u578b\u7ec6\u80de\u7684\u5f02\u8d28\u6027\uff0c\u5e76\u4f53\u5185\u5e73\u8861\u548c\u7ec4\u7ec7\u4fee\u590d\u8fc7\u7a0b\u4e2d\u5206\u8fa8\u51fa\u4e86\u660e\u663e\u7684\u5206\u5316\u8f68\u8ff9\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5c3d\u7ba1\u76ee\u524d\u5df2\u6709\u51e0\u79cd\u7ecf\u8fc7\u6279\u51c6\u7684\u56ca\u6027\u7ea4\u7ef4\u6cbb\u7597\u65b9\u6cd5\uff0c\u5982Kalydeco\u3001Orkambi\u548cSymdeko\uff0c\u90fd\u65e8\u5728\u7ea0\u6b63\u7531<em>CFTR<\/em>\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u529f\u80fd\u5931\u8c03\u6216\u86cb\u767d\u8d28\u7f3a\u4e4f\uff0c\u4f46\u5b83\u4eec\u5e76\u4e0d\u80fd\u76f4\u63a5\u9488\u5bf9<em>CFTR<\/em>\u57fa\u56e0\u7a81\u53d8\u3002\u8fd9\u9879\u65b0\u7814\u7a76\u53d1\u73b0\u53ef\u4ee5\u589e\u5f3a\u672a\u6765\u7684\u56ca\u6027\u7ea4\u7ef4\u5316\u6cbb\u7597\uff0c\u4f7f\u5f00\u53d1\u56ca\u6027\u7ea4\u7ef4\u5316\u57fa\u56e0\u6cbb\u7597\u6210\u4e3a\u4e86\u53ef\u80fd\u3002&nbsp;<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">1.New Lung Cell Type Linked to Cystic Fibrosis Emerges From Mouse, Human Cell Atlas Studies<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">2.Lung cell discovery opens new route for cystic fibrosis treatment<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">3.Rare Lung Cell Type Appears to Play Important Role in Cystic Fibrosis<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><strong style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;image-rendering: -webkit-optimize-contrast;box-sizing: border-box !important;word-wrap: break-word !important;\">\u00b7&nbsp;END&nbsp;\u00b7<\/span><\/strong><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533789277.gif\" alt=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\" title=\"\u540c\u65e5\u4e24\u7bc7Nature\u91cd\u78c5\u53d1\u5e03\uff01\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53d1\u73b0\u5168\u65b0\u7ec6\u80de\u7c7b\u578b\"><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u6d4b\u5e8f\u4e2d\u56fd                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u8ba4\u8bc6\u540c\u4e00\u7ec4\u7ec7\u4e2d\u7684\u4e0d\u540c\u7ec6\u80de\uff0c\u4ee5\u53ca\u540c\u4e00\u7ec6\u80de\u4e2d\u4e0d\u540c\u57fa\u56e0\u7684\u8868\u8fbe\u60c5\u51b5\u3002\u6b64\u524d\u79d1\u5b66\u5bb6\u5728\u80ba\u90e8\u8bc6\u522b\u51fa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":34212,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34211"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=34211"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34211\/revisions"}],"predecessor-version":[{"id":34223,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34211\/revisions\/34223"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/34212"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=34211"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=34211"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=34211"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}