{"id":34241,"date":"2018-08-01T01:00:00","date_gmt":"2018-08-09T04:34:49","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e9%87%8d%e7%a3%85%ef%bc%81%e4%b8%8a%e6%b5%b7%e5%98%89%e5%9b%a0%e7%94%9f%e7%89%a9%e5%85%a8%e7%90%83%e9%a6%96%e5%8f%91-%e5%8d%81%e4%b8%87%e6%a0%b7%e6%9c%ac%e5%bc%80%e6%94%be%e6%9f%93%e8%89%b2\/"},"modified":"2018-08-09T12:34:54","modified_gmt":"2018-08-09T04:34:54","slug":"%e9%87%8d%e7%a3%85%ef%bc%81%e4%b8%8a%e6%b5%b7%e5%98%89%e5%9b%a0%e7%94%9f%e7%89%a9%e5%85%a8%e7%90%83%e9%a6%96%e5%8f%91-%e5%8d%81%e4%b8%87%e6%a0%b7%e6%9c%ac%e5%bc%80%e6%94%be%e6%9f%93%e8%89%b2","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/34241\/","title":{"rendered":"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"margin: 5px 0.5em 25px;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><img class=\"\"       style=\"text-align: justify;white-space: normal;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533789290.jpg\" alt=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\" title=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\"  \/><\/span><\/p>\n<p style=\"margin: 5px 0.5em 25px;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;\">\u5317\u4eac\u65f6\u95f42018\u5e748\u67081\u65e5\u6d88\u606f\uff0c\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u5609\u56e0\u751f\u7269\u201d\uff09\u5ba3\u5e03\u542f\u52a8\u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d \u2014\u2014 X-ATAC \u8ba1\u5212\u3002\u8be5\u8ba1\u5212\u65e8\u901a\u8fc73\u5e74\u65f6\u95f4\uff0c\u5728\u4e2d\u56fd\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u57fa\u56e0\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\u3002\u636e\u4ecb\u7ecd\uff0c\u8be5\u8ba1\u5212\u5305\u62ec\u4e24\u5927\u884c\u52a8\u4efb\u52a1\uff1a\u9996\u671f\uff0c\u5609\u56e0\u751f\u7269\u5c06\u5728\u56fd\u5185\u5b8c\u62103\u4e07\u4f8b\u6837\u672c\u7684 ATAC-seq\u5b9e\u9a8c\uff0c\u548c\u76f8\u5e94\u7684\u6570\u636e\u5206\u6790\u5de5\u4f5c\uff1b\u540e\u671f\uff0c\u5609\u56e0\u751f\u7269\u4f1a\u8fdb\u4e00\u6b65\u5c06\u53ef\u7eb3\u5165\u6837\u672c\u548c\u76f8\u5173\u7814\u7a76\u6269\u5927\u81f3\u5168\u7403\u8303\u56f4\u3002<\/span><\/strong><br  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong>\u5609\u56e0\u751f\u7269CEO\u3001\u4e0a\u6d77\u5e02\u6d66\u6c5f\u4eba\u624d\u674e\u65e6\u535a\u58eb<\/strong>\u8868\u793a\uff0c\u5609\u56e0\u751f\u7269\u4e3b\u5bfc\u6784\u5efa\u7684\u57fa\u56e0\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\uff0c\u5c06\u4e3a\u751f\u7269\u57fa\u7840\u7814\u7a76\uff0c\u533b\u5b66\u4e34\u5e8a\u7814\u7a76\u4e43\u81f3\u75be\u75c5\u68c0\u6d4b\u548c\u6cbb\u7597\u7b49\u5e94\u7528\u63d0\u4f9b\u57fa\u7840\u53c2\u8003\u6570\u636e\u5e93\u3002\u540c\u65f6\uff0c\u8be5\u8ba1\u5212\u8fd8\u5c06\u5e2e\u52a9\u5efa\u7acb\u7cbe\u51c6\u533b\u5b66\u76f8\u5173\u6807\u51c6\uff0c\u4e3a\u56fd\u5185\u5916\u5404\u79d1\u7814\u5355\u4f4d\u548c\u533b\u7597\u673a\u6784\u7684\u7cbe\u51c6\u8bca\u65ad\u548c\u7cbe\u51c6\u6cbb\u7597\u63d0\u4f9b\u514d\u8d39\u7684\u8868\u89c2\u9057\u4f20\u548c\u8f6c\u5f55\u8c03\u63a7\u5c42\u9762\u7684\u53c2\u8003\u6570\u636e\u96c6\u3002<\/span><\/p>\n<section style=\"box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\" style=\"box-sizing: border-box;\" >\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 10%;box-sizing: border-box;\"><img     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533789290.png\" alt=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\" title=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\"  \/><\/section>\n<section class=\"\" style=\"display: inline-block;vertical-align: middle;border-top: 1px dashed rgb(62, 62, 62);border-bottom: 1px dashed rgb(62, 62, 62);border-right-color: rgb(62, 62, 62);border-left-color: rgb(62, 62, 62);margin: 0.9em 2px 0.6em;padding-top: 2px;padding-bottom: 2px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"font-size: 18px;text-align: center;white-space: normal;\"><span style=\"max-width: 100%;color: rgb(0, 66, 121);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u7684<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><strong style=\"font-size: 18px;text-align: center;white-space: normal;\"><span style=\"max-width: 100%;color: rgb(0, 66, 121);box-sizing: border-box !important;word-wrap: break-word !important;\">\u9769\u547d\u6027\u6280\u672f\uff1aATAC-seq<\/span><\/strong><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: bottom;width: 10%;box-sizing: border-box;\"><img     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533789290.png\" alt=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\" title=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;\">ATAC-seq\u6280\u672f\u4e8e2013\u5e74\u53d1\u8868\u5728<\/span><em style=\"font-size: 15px;\">Nature Methods<\/em><span style=\"font-size: 15px;\">\u6742\u5fd7\u4e0a\uff0c\u8be5\u6280\u672f\u53ef\u5728\u5168\u57fa\u56e0\u7ec4\u5c3a\u5ea6\u4e0b\u5bf9\u5f00\u653e\u67d3\u8272\u8d28\u533a\u57df\u8fdb\u884c\u7cbe\u786e\u5b9a\u4f4d\u3002\u968f\u540e\u7684\u51e0\u5e74\uff0c\u8be5\u6280\u672f\u88ab\u8fdb\u4e00\u6b65\u4f18\u5316\uff0c\u53ef\u9002\u7528\u7684\u6837\u672c\u7c7b\u578b\u4ece\u7ec6\u80de\u9010\u6e10\u6269\u5927\u81f3\u5404\u7c7b\u7ec4\u7ec7\u548c\u5355\u7ec6\u80de\u6837\u672c\uff0c\u5728\u764c\u75c7\uff0c\u53d1\u80b2\uff0c\u514d\u75ab\uff0c\u795e\u7ecf\u7b49\u9886\u57df\u4e2d\u88ab\u5e7f\u6cdb\u5e94\u7528\u3002\u5f00\u653e\u67d3\u8272\u8d28\u533a\u57df\u5305\u542b\u4e86\u5927\u91cf\u91cd\u8981\u7684\u975e\u7f16\u7801\u8c03\u63a7\u5143\u4ef6\uff0c\u5305\u62ec\u589e\u5f3a\u5b50\uff08enhancer\uff09\u3001\u542f\u52a8\u5b50\uff08promoter\uff09\u548c\u7edd\u7f18\u5b50\uff08insulator\uff09\uff0c\u8fd9\u4e9b\u8c03\u63a7\u539f\u4ef6\u5728\u8f6c\u5f55\u8c03\u63a7\u4e2d\u8d77\u5230\u91cd\u8981\u4f5c\u7528 \uff0c\u56e0\u6b64ATAC-seq\u4f7f\u5168\u9762\u7814\u7a76\u8f6c\u5f55\u8c03\u63a7\u6210\u4e3a\u53ef\u80fd\u3002\u5c31\u5176\u6280\u672f\u672c\u8eab\u800c\u8a00\uff0c<strong>ATAC-seq\u6280\u672f\u662f\u63a2\u7a76\u75be\u75c5\u6210\u56e0\u3001\u8868\u578b\u5f62\u6210\u548c\u690d\u7269\u5e94\u6fc0\u53cd\u5e94\u7684\u5206\u5b50\u673a\u5236\u7684\u6709\u529b\u5de5\u5177\uff0c\u5b83\u7684\u9002\u7528\u9762\u5e7f\uff0c\u53ef\u5e94\u7528\u4e8e\u5404\u79cd\u7269\u79cd\u4e0e\u6837\u672c\u6765\u6e90\uff0c\u5e76\u53ef\u4ee5\u4f5c\u4e3aChIP-seq\u7684\u66ff\u4ee3\u54c1<\/strong>\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;\">UCLA\u751f\u7269\u4fe1\u606f\u5b66\u7cfb\u738b\u7a0b\u626c\u535a\u58eb<\/span><\/strong><span style=\"font-size: 15px;\">\u544a\u8bc9\u6d4b\u5e8f\u4e2d\u56fd\uff0c\u76ee\u524d\u5609\u56e0\u751f\u7269\u5df2\u7ecf\u5b8c\u6210600\u591a\u4f8bATAC-seq\u5b9e\u9a8c\uff0c\u6210\u529f\u6848\u4f8b\u5df2\u7ecf\u5168\u9762\u8986\u76d6\u5404\u7269\u79cd\u95e8\u7c7b\u548c\u6837\u672c\u7c7b\u578b\uff0c\u5305\u62ec\u690d\u7269\uff0c\u52a8\u7269\uff0c\u4eba\u7ec4\u7ec7\uff0c\u8840\u6db2\u7ec6\u80de\uff0c\u80bf\u7624\uff0c\u6d77\u6d0b\u751f\u7269\uff0c\u6606\u866b\uff0c\u771f\u83cc\u3001\u4f4e\u7ec6\u80de\u91cf\u7b49\u7b49\uff08\u4ee3\u8868\u7269\u79cd\u89c1\u56fe1\uff09\u3002\u7ecf\u8fc74\u5e74\u7684\u53d1\u5c55\uff0c\u5609\u56e0\u751f\u7269\u5df2\u7ecf\u6210\u957f\u4e3a\u4e2d\u56fd\u8868\u89c2\u9057\u4f20\u5b66\u5b9e\u9a8c\u670d\u52a1\u548c\u6570\u636e\u5206\u6790\u670d\u52a1\u7684\u9886\u8dd1\u8005\uff0c\u5e76\u671d\u7740\u4e16\u754c\u7b2c\u4e00\u7684\u8868\u89c2\u9057\u4f20\u5b66\u670d\u52a1\u5546\u52aa\u529b\u594b\u8fdb\u3002\u76ee\u524d\uff0c\u516c\u53f8\u5728\u7a33\u56fa ChIP-seq\uff0cBisulfite-seq\u548cATAC-seq\u8fd9\u4e09\u9879\u5b9e\u9a8c\u7684\u57fa\u7840\u4e0a\uff0c\u53c8\u8fdb\u4e00\u6b65\u7814\u53d1\u4e86 MeRIP-seq\u548cHi-C\u7b49\u591a\u79cd\u8868\u89c2\u9057\u4f20\u5b66\u5b9e\u9a8c\u6280\u672f\u3002\u6b64\u5916\uff0c\u5609\u56e0\u751f\u7269\u56e2\u961f\u5728\u4e0a\u6d77\u70c8\u51b0\u79d1\u6280\u7684\u4e91\u5e73\u53f0\u57fa\u7840\u4e0a\uff0c\u8fdb\u4e00\u6b65\u5f00\u53d1\u4e86\u8868\u89c2\u9057\u4f20\u5b66\u7684\u6570\u636e\u5206\u6790\u7cfb\u7edf\uff0c\u5e76\u5c06\u4e8e\u4eca\u5e749\u6708\u6b63\u5f0f\u542f\u7528 \u201c\u5609\u56e0\u751f\u7269\u8868\u89c2\u4e91\u5e73\u53f0\u201d\uff0c\u4e3a\u4e2d\u56fd\u7684\u8868\u89c2\u9057\u4f20\u5b66\u7684\u6570\u636e\u5206\u6790\u63d0\u4f9b\u66f4\u591a\u4fbf\u5229\u3002<\/span><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"           style=\"width: 541px;height: 666px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533789291.jpeg\" alt=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\" title=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\"  \/><\/p>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;text-align: center;\">\u56fe1&nbsp;.&nbsp;\u5609\u56e0\u751f\u7269ATAC-seq\u6210\u529f\u6848\u4f8b\u7cbe\u9009<\/span><br  \/><\/p>\n<section style=\"box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\" style=\"box-sizing: border-box;\" >\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 10%;box-sizing: border-box;\"><img     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533789291.png\" alt=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\" title=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\"  \/><\/section>\n<section class=\"\" style=\"display: inline-block;vertical-align: middle;border-top: 1px dashed rgb(62, 62, 62);border-bottom: 1px dashed rgb(62, 62, 62);border-right-color: rgb(62, 62, 62);border-left-color: rgb(62, 62, 62);margin: 0.9em 2px 0.6em;padding-top: 2px;padding-bottom: 2px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"color: rgb(0, 66, 121);font-size: 18px;text-align: center;white-space: normal;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">X-ATAC\u8ba1\u5212\u52bf\u5728\u5fc5\u884c<\/span><\/strong><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;vertical-align: bottom;width: 10%;box-sizing: border-box;\"><img     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533789291-1.png\" alt=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\" title=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;\">\u636e\u6089\uff0c\u5609\u56e0\u751f\u7269\u7684X-ATAC\u6d4b\u5e8f\u8ba1\u5212\u5c06\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u4e13\u95e8\u9488\u5bf9\u67d3\u8272\u8d28\u5f00\u653e\u533a\u57df\u8fdb\u884c\u6d4b\u5e8f\u7684\u5927\u578b\u9879\u76ee\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u8be5\u9879\u76ee\u7684\u603b\u4f53\u76ee\u6807\u662f\u7834\u89e3DNA\u5e8f\u5217\u5916\u7684\u53e6\u4e00\u534a\u751f\u547d\u201c\u5bc6\u7801\u201d\u2014\u2014\u8868\u89c2\u9057\u4f20\u5b66\uff0c<strong>\u7ed8\u5236\u89c4\u6a21\u6700\u5927\u7684\u201c\u8868\u89c2\u9057\u4f20\u5b66\u53c2\u6bd4\u56fe\u8c31\u201d<\/strong>\uff0c<strong>\u5e76\u8fdb\u4e00\u6b65\u5efa\u7acb\u57fa\u56e0\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93<\/strong><strong>\uff0c\u4ece\u800c\u4e3a\u7814\u7a76\u5404\u79cd\u751f\u7269\u4f53\u5185\u7684\u8f6c\u5f55\u8c03\u63a7\u673a\u5236\u4ee5\u53ca\u4e34\u5e8a\u7814\u7a76\u5efa\u7acb\u57fa\u7840\u53c2\u8003\u6570\u636e\u5e93<\/strong>\u3002<\/span><\/p>\n<section style=\"box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\" style=\"box-sizing: border-box;\" >\n<section class=\"\" style=\"text-align: center;margin: 10px 0%;box-sizing: border-box;\">\n<section class=\"group-empty\" style=\"display: inline-block;vertical-align: top;overflow: hidden;height: 150px;width: 150px;background-position: 0% 11.9048%;background-repeat: no-repeat;background-size: 100%;background-attachment: scroll;box-shadow: rgb(62, 62, 62) -2px 0px 4px inset;border-radius: 50%;border-width: 0px;border-style: none;border-color: rgb(62, 62, 62);background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533789293.jpeg');box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em 15px;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5218\u5c0f\u4e50\u535a\u58eb<\/span><\/p>\n<p style=\"margin: 10px 0.5em 25px;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"font-size: 15px;\">\u54c8\u4f5b\u5927\u5b66\u4e0e\u7f8e\u56fdDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u7ec8\u8eab\u6559\u6388\u3001\u529f\u80fd\u6027\u8868\u89c2\u9057\u4f20\u5b66\u4e2d\u5fc3\u4e3b\u4efb\u5218\u5c0f\u4e50\u535a\u58eb<\/span><\/strong><span style=\"font-size: 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class=\"Powered-by-XIUMI V5\" style=\"box-sizing: border-box;\" >\n<section class=\"\" style=\"text-align: center;margin: 10px 0%;box-sizing: border-box;\">\n<section class=\"group-empty\" style=\"display: inline-block;vertical-align: top;overflow: hidden;height: 150px;width: 150px;background-position: 0% 0%;background-repeat: no-repeat;background-size: 100%;background-attachment: scroll;box-shadow: rgb(62, 62, 62) -2px 0px 4px inset;border-radius: 50%;border-width: 0px;border-style: none;border-color: rgb(62, 62, 62);background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533789293.jpeg');box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em 15px;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u674e\u7a0b\u7814\u7a76\u5458<\/span><\/p>\n<p style=\"margin: 15px 0.5em 25px;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5317\u4eac\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u674e\u7a0b\u7814\u7a76\u5458<\/span><\/strong><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word 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border-box;\">\n<section class=\"group-empty\" style=\"display: inline-block;vertical-align: top;overflow: hidden;height: 150px;width: 150px;background-position: 0% 22.0219%;background-repeat: no-repeat;background-size: 100%;background-attachment: scroll;box-shadow: rgb(62, 62, 62) -2px 0px 4px inset;border-radius: 50%;border-width: 0px;border-style: none;border-color: rgb(62, 62, 62);background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533789294.jpeg');box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em 15px;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6c5f\u8d50\u5fe0\u535a\u58eb<\/span><\/p>\n<p style=\"margin: 10px 0.5em 25px;max-width: 100%;white-space: normal;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u540c\u6d4e\u5927\u5b66\u751f\u547d\u79d1\u5b66\u4e0e\u6280\u672f\u5b66\u9662\u7279\u8058\u6559\u6388\u3001973\u91cd\u5927\u4e13\u9879\u9996\u5e2d\u79d1\u5b66\u5bb6\u6c5f\u8d50\u5fe0\u535a\u58eb<\/span><\/strong><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word 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normal;width: 250px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533789291.jpeg\" alt=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\" title=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\"  \/><\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;text-align: center;\"><strong style=\"white-space: normal;color: rgb(0, 66, 121);font-size: 16px;text-align: center;background-color: rgb(255, 255, 255);\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5173\u4e8e\u5609\u56e0\u751f\u7269\uff1a\u4e2d\u56fd\u8868\u89c2\u9057\u4f20\u5b66\u6280\u672f\u670d\u52a1\u7684\u9886\u8dd1\u8005<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;text-align: justify;margin-top: 15px;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5609\u56e0\u751f\u7269\u521b\u5efa\u4e8e2014\u5e74\uff0c\u662f\u4e2d\u56fd\u8868\u89c2\u9057\u4f20\u5b66\u5b9e\u9a8c\u670d\u52a1\u548c\u5206\u6790\u670d\u52a1\u7684\u9886\u8dd1\u8005\uff0c\u63d0\u4f9b\u4ee5 ChIP-seq\uff0cBisulfite-seq\uff0cATAC-seq\uff0cMeRIP-Seq\u548cHi-C\u4e3a\u4e3b\u7684\u5b9e\u9a8c\u670d\u52a1\u548c\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u670d\u52a1\u3002\u622a\u81f3\u76ee\u524d\uff0c\u5609\u56e0\u751f\u7269\u5df2\u7d2f\u8ba1\u5b8c\u6210\u5404\u7c7b\u8868\u89c2\u9057\u4f20\u5b66\u5b9e\u9a8c2000\u4f59\u4f8b\uff0cATAC-seq\u548c\u7ec4\u86cb\u767d\u4fee\u9970\u7684ChIP-seq\u6210\u529f\u7387\u63a5\u8fd1100%\uff0c\u8f6c\u5f55\u56e0\u5b50ChIP-seq\u6210\u529f\u7387&gt;80%\u3002\u5609\u56e0\u751f\u7269\u4e13\u6ce8\u4e8e\u8868\u89c2\u9057\u4f20\u5b66\u9886\u57df\uff0c\u5b9e\u9a8c\u6280\u672f\u6e90\u81ea\u54c8\u4f5b\u5927\u5b66\u3001\u591a\u4f26\u591a\u5927\u5b66\u3001UCLA\u548cUNC\u7684\u5408\u4f5c\u5b9e\u9a8c\u5ba4\uff0c\u5206\u6790\u56e2\u961f\u5f15\u5165\u4e86\u6765\u81eaUCLA\u548c\u4e2d\u79d1\u9662\u7684\u4f18\u79c0\u535a\u58eb\u3002\u5609\u56e0\u751f\u7269\u53c2\u4e0e\u53d1\u8868\u7684\u8868\u89c2\u9057\u4f20\u5b66\u6587\u7ae0\u5df2\u8fbe20\u4f59\u7bc7\uff0c\u5305\u62ecNature\u3001PNAS\u3001Nature Communication\u7b49\u56fd\u9645\u77e5\u540d\u6742\u5fd7\uff1b\u5df2\u53d1\u8868\u7684\u8868\u89c2\u9057\u4f20\u5b66\u76f8\u5173\u6587\u7ae0\u7684\u603b\u5f71\u54cd\u56e0\u5b50&gt;300\u5206\uff0c\u7bc7\u6570\u548c\u7d2f\u8ba1\u5f71\u54cd\u56e0\u5b50\u5747\u4e3a\u4e2d\u56fd\u5927\u9646\u5de5\u4e1a\u754c\u699c\u9996\u3002\u5609\u56e0\u751f\u7269\u662f\u4e0a\u6d77\u5e02\u9ad8\u65b0\u6280\u672f\u4f01\u4e1a\uff0c\u5e76\u4e8e2015\u5e74\u6302\u724c\u535a\u58eb\u540e\u5b9e\u8df5\u57fa\u5730\uff0c\u4e0e\u4e2d\u79d1\u9662\u8054\u5408\u8fdb\u884c\u535a\u58eb\u540e\u57f9\u517b\u3002<\/span><\/p>\n<p style=\"box-sizing: border-box;text-align: justify;margin-top: 15px;\"><span style=\"font-size: 14px;text-align: left;color: rgb(0, 66, 121);\"><strong>\u4f01\u4e1a\u7f51\u7ad9\uff1a<\/strong><\/span><span style=\"font-size: 14px;text-align: left;color: rgb(136, 136, 136);\">http:\/\/www.rainbow-genome.com&nbsp;<\/span><\/p>\n<p style=\"box-sizing: border-box;text-align: justify;margin-top: 15px;\"><strong style=\"color: rgb(255, 255, 255);font-size: 14px;text-align: left;\"><span style=\"font-size: 14px;color: rgb(0, 66, 121);\">\u4f01\u4e1a\u8054\u7cfb\u90ae\u7bb1\uff1a<\/span><\/strong><span style=\"font-size: 14px;text-align: left;color: rgb(136, 136, 136);\">marketing@rainbow-genome.com&nbsp;<\/span><\/p>\n<p style=\"box-sizing: border-box;text-align: justify;margin-top: 15px;\"><span style=\"font-size: 14px;text-align: left;color: rgb(0, 66, 121);\"><strong>\u4f01\u4e1a\u8054\u7cfb\u7535\u8bdd\uff1a<\/strong><\/span><span style=\"font-size: 14px;text-align: left;color: rgb(136, 136, 136);\">021-61539657<\/span><\/p>\n<p style=\"box-sizing: border-box;text-align: justify;margin-top: 15px;\"><span style=\"font-size: 14px;text-align: left;color: rgb(0, 66, 121);\"><strong>\u516c\u4f17\u53f7ID<\/strong><\/span><span style=\"font-size: 14px;text-align: left;color: rgb(0, 66, 121);\">\uff1a<\/span><span style=\"font-size: 14px;text-align: left;color: rgb(136, 136, 136);\">Figure72h<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: right;margin: 20px 0% -30px;transform: translate3d(16px, 0px, 0px);-webkit-transform: translate3d(16px, 0px, 0px);-moz-transform: translate3d(16px, 0px, 0px);-o-transform: translate3d(16px, 0px, 0px);box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 50%;vertical-align: top;background-color: rgb(255, 255, 255);padding-left: 10px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: -10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" x=\"0px\" y=\"0px\" viewbox=\"0 0 536.1 59.2\" style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\" width=\"536.1\"><g style=\"box-sizing: border-box;\"><polygon points=\"533.5,3 518.7,19.1 503.1,1 486.9,18.6 471.3,0.5 455.1,18.1 439.5,0 422,19.1 424.6,21.5 439.4,5.3 455,23.4    471.2,5.8 486.8,23.9 503,6.3 518.6,24.4 536.1,5.4\" fill=\"#000000\" style=\"box-sizing: border-box;\"><\/polygon><g style=\"box-sizing: border-box;\"><polygon points=\"89.5,28.7 82.5,39.3 96.5,39.3\" fill=\"#000000\" style=\"box-sizing: border-box;\"><\/polygon><polygon points=\"68.9,28.7 61.9,39.3 75.9,39.3\" fill=\"#000000\" style=\"box-sizing: border-box;\"><\/polygon><polygon points=\"48.2,28.7 41.3,39.3 55.2,39.3\" fill=\"#000000\" style=\"box-sizing: border-box;\"><\/polygon><polygon points=\"27.6,28.7 20.6,39.3 34.6,39.3\" fill=\"#000000\" style=\"box-sizing: border-box;\"><\/polygon><polygon points=\"7,28.7 0,39.3 14,39.3\" fill=\"#000000\" style=\"box-sizing: border-box;\"><\/polygon><\/g><g style=\"box-sizing: border-box;\"><rect x=\"144.2\" y=\"36.9\" width=\"328.3\" height=\"3.6\" fill=\"rgb(44,137,233)\" style=\"box-sizing: border-box;\"><\/rect><\/g><g style=\"box-sizing: border-box;\"><rect x=\"41.3\" y=\"55.6\" width=\"448.1\" height=\"3.6\" fill=\"#000000\" style=\"box-sizing: border-box;\"><\/rect><\/g><\/g><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 10px 0%;text-align: center;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"font-size: 15px;color: rgb(51, 51, 51);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;image-rendering: -webkit-optimize-contrast;box-sizing: border-box !important;word-wrap: break-word !important;\">\u00b7&nbsp;END&nbsp;\u00b7<\/span><\/strong><\/p>\n<p style=\"margin: 25px 0.5em 10px;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u957f\u6309\u8bc6\u522b\u4e0b\u65b9\u4e8c\u7ef4\u7801\uff0c\u70b9\u51fb<strong>\u201c\u8bfe\u7a0b\u62a5\u540d\u201d<\/strong>\uff0c\u8fdb\u5165<strong>\u201c\u5f00\u8bb2\u5566\uff0c\u4e00\u4f5c\uff01\u201d<\/strong>\uff0c\u7acb\u5373\u62a5\u540d\u514d\u8d39\u542c\u8bfe\uff01<\/span><\/p>\n<p style=\"margin: 10px 0.5em 25px;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"margin: 25px 0.5em;max-width: 100%;white-space: normal;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"__bg_gif\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533789292.gif\" alt=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\" title=\"\u91cd\u78c5\uff01\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u5168\u7403\u9996\u53d1 \u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b\u5e8f\u8ba1\u5212\u201d X-ATAC\uff0c\u5c06\u5efa\u7acb\u4e16\u754c\u9886\u5148\u7684\u8f6c\u5f55\u8c03\u63a7\u6570\u636e\u5e93\"  \/><br  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u6d4b\u5e8f\u4e2d\u56fd                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5317\u4eac\u65f6\u95f42018\u5e748\u67081\u65e5\u6d88\u606f\uff0c\u4e0a\u6d77\u5609\u56e0\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u5609\u56e0\u751f\u7269\u201d\uff09\u5ba3\u5e03\u542f\u52a8\u201c\u5341\u4e07\u6837\u672c\u5f00\u653e\u67d3\u8272\u8d28\u6d4b [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":34242,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34241"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=34241"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34241\/revisions"}],"predecessor-version":[{"id":34258,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/34241\/revisions\/34258"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/34242"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=34241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=34241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=34241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}