{"id":37015,"date":"2018-08-27T01:00:00","date_gmt":"2018-09-17T06:09:49","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e6%ba%b6%e5%87%ba%e4%b8%8d%e7%9b%b8%e4%bc%bcbe%e7%ad%89%e6%95%88%ef%bc%9f-818%e9%82%a3%e4%ba%9b%e8%89%ba%e9%ab%98%e4%ba%ba%e8%83%86%e5%a4%a7%e7%9a%84%e6%97%a5%e6%9c%ac%e4%bb%bf\/"},"modified":"2018-09-17T14:09:57","modified_gmt":"2018-09-17T06:09:57","slug":"%e6%ba%b6%e5%87%ba%e4%b8%8d%e7%9b%b8%e4%bc%bcbe%e7%ad%89%e6%95%88%ef%bc%9f-818%e9%82%a3%e4%ba%9b%e8%89%ba%e9%ab%98%e4%ba%ba%e8%83%86%e5%a4%a7%e7%9a%84%e6%97%a5%e6%9c%ac%e4%bb%bf","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/37015\/","title":{"rendered":"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b"},"content":{"rendered":"
\n
<\/mpcps><\/section>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"
<\/p>\n

\n
\n
\n
\n
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\u5916\u8d44\u5927\u578b\u5236\u836f\u516c\u53f8\u6280\u672f\u3001\u7814\u53d1\u3001\u8d28\u91cf\u603b\u76d1\uff0c\u9a8c\u8bc1\u7ba1\u7406\u8d44\u6df1\u4e13\u5bb6\uff0c\u591a\u5bb6\u5236\u836f\u516c\u53f8\u987e\u95ee\uff0c\u836f\u5b66\u7855\u58eb\u3002\u56fd\u5bb6\u5de5\u827a\u6838\u5bf9\u672a\u96e8\u7ef8\u7f2a\u4e4b\u9645\uff0c\u6210\u529f\u89e3\u51b3\u4e86\u591a\u5bb6\u5728\u4ea7\u4ea7\u54c1\u5904\u65b9\u3001\u5de5\u827a\u95ee\u9898\u3002\u5904\u65b9\u5de5\u827a\u7684\u4e8c\u6b21\u5f00\u53d1\uff0c\u514d\u8d39\u54a8\u8be2\uff0c\u5168\u7a0b\u4fdd\u5bc6\u3002\u90ae\u7bb1\uff1a1193686015@qq.com\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

<\/span><\/p>\n

1.\u6982\u8ff0<\/span>|<\/span>\u653e\u4e0b\u6eb6\u51fa\u4e00\u81f4\u7684\u6267\u5ff5\uff0c\u8fd8\u80fd\u6293\u4f4fBE\u8fd9\u53ea\u859b\u5b9a\u8c14\u7684\u732b\u5417\uff1f<\/span><\/span><\/h1>\n


<\/span><\/p>\n

\u5982\u4f55\u901a\u8fc7\u6eb6\u51fa\u5206\u6790\u63d0\u9ad8<\/span>BE\u7684\u6210\u529f\u7387\u4e00\u76f4\u662f\u4e1a\u5185\u8ba8\u8bba\u7684\u70ed\u70b9\uff0c\u4e1a\u5185\u5927\u5496\u4eec\u4e5f\u7eb7\u7eb7\u63d0\u4f9b\u8bb8\u591a\u5b9d\u8d35\u53c2\u8003\u610f\u89c1\uff08<\/span>\u8be6\u89c1\u603b\u7ed3\uff1a100\u7bc7\u6587\u7ae0\u52a9\u4f60\u6210\u4e3aI\u671f\u4e34\u5e8a\/BE\/\u6eb6\u51fa\u8bd5\u9a8c\u65b9\u9762\u7684\u4e13\u5bb6<\/span><\/em>\uff09\uff0c\u4e1a\u5185\u5171\u8bc6\u4e4b\u4e00\uff0c\u627e\u5230\u6709\u9884\u6d4b\u6027\u7684\u6eb6\u51fa\u66f2\u7ebf\uff0c\u6839\u636e\u836f\u7269\u5438\u6536\u6027\u8d28\u5224\u65ad<\/span>BE\u98ce\u9669\uff08<\/span>\u603b\u7ed3\u89c1\u4e0b\u56fe<\/span><\/em>\uff09\u3002\u76ee\u524d\u6d41\u901a\u6c60\u3001<\/span>TIM-1\u7cfb\u7edf\u3001<\/span>GastroPlus\u5e94\u7528\u5c1a\u4e0d\u666e\u53ca\uff0c\u5e38\u89c4\u6eb6\u51fa\u88c5\u7f6e\u5f00\u5c55\u7684\u6eb6\u51fa\u591a\u6b62\u4e8e\u5bf9\u5236\u5242\u4ea7\u54c1\u7684\u7406\u5316\u6027\u8d28\u7684\u4e0d\u540c\u6709\u533a\u5206\u529b\uff0c\u5728\u9884<\/span>BE\u4e4b\u524d\u7ec8\u7a76\u4e5f\u53ea\u7b97\u96fe\u91cc\u770b\u82b1\u3002<\/span><\/p>\n


<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n


<\/span><\/h1>\n

2.\u6848\u4f8b<\/span>|<\/span>\u5927\u80c6 \uff0c\u65e5\u672c\uff01\u8fd9\u6837\u4e0aBE\uff0c\u4f60\u4eec\u662f\u50bb\u8fd8\u662f\u7cbe\uff1f<\/span><\/span><\/h1>\n


<\/span><\/p>\n

\u4eff\u5236\u836f\u548c\u539f\u7814\u836f\u7684\u6bcf\u6761\u6eb6\u51fa\u66f2\u7ebf\u4e00\u81f4\u56fa\u7136\u662f\u6bcf\u4e2a\u5236\u5242\u7814\u7a76\u8005\u7684\u8ffd\u6c42\uff0c\u5948\u4f55\u9650\u4e8e\u73b0\u5b9e\u56e0\u7d20\uff0c\u5f80\u5f80\u53ea\u80fd\u611f\u6168\uff0c\u201c\u81e3\u59be\u505a\u4e0d\u5230\u5440\u201d\uff01\u5bf9\u4e8e\u6eb6\u51fa\u4e0e<\/span>BE\u7684\u5173\u7cfb\uff0c\u53ea\u6709\u5e7f\u79ef\u5b9e\u4f8b\uff0c\u6df1\u5165\u5206\u6790\uff0c\u624d\u80fd\u63d0\u9ad8\u5224\u65ad\u529b\u3002\u73b0\u63d0\u4f9b\u4e09\u4f8b\u65e5\u672c\u5df2\u4e0a\u5e02\u7684\u4eff\u5236\u6848\u4f8b\uff0c\u5e76\u7ed9\u51fa\u7b14\u8005\u7684\u4e2a\u4eba\u5206\u6790\uff0c\u4f9b\u53c2\u8003\u8ba8\u8bba<\/span>\uff08\u5b9e\u9645\u53ef\u80fd\u662f\u5148BE\u7b49\u6548\u518d\u5f00\u5c55\u4f53\u5916\u7814\u7a76\uff09<\/span><\/em>\u3002<\/span><\/p>\n

 <\/p>\n

No.1\u2014\u2014<\/span>\u5c3c\u514b\u836f\u4e1a\u7684\u7eb3\u544b\u62c9\u5561\u8f6f\u80f6\u56ca<\/span><\/strong><\/p>\n

\u3010\u5173\u952e\u8bcd\u3011<\/span><\/strong>\u8f85\u6599\u3001\u5438\u6536\u673a\u5236\u3001\u8102\u8d28\u5236\u5242<\/span><\/p>\n

\u3010\u6eb6\u51fa\u66f2\u7ebf\u3011<\/span><\/strong>\u6240\u6709\u66f2\u7ebf\u5747\u4e0d\u76f8\u4f3c<\/span>\uff08\u5bf9\uff0c\u4f60\u6ca1\u6709\u770b\u9519\uff0c\u4f53\u5916\u53ef\u7b97\u60e8\u4e0d\u5fcd\u7779\uff09<\/span><\/em>\u3002\u53c2\u6bd4<\/strong><\/span>15min<\/strong>\u6eb6\u51fa\uff1e<\/span><\/strong>85%<\/strong>\uff0c\u4eff\u5236\u4ea7\u54c1<\/span><\/strong>30min<\/strong>\u6eb6\u51fa\u8fd8\u4e0d\u5230<\/span><\/strong>60%\u3002<\/strong><\/p>\n


<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

<\/span><\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

<\/span>
<\/p>\n

\u3010<\/span><\/strong>BE<\/strong>\u7ed3\u679c\u3011<\/span><\/strong>20\u4f8b\u7a7a\u8179\u5065\u5eb7\u5fd7\u613f\u8005<\/span>BE\u7ed3\u679c\u663e\u793a\u7b49\u6548\uff08\u867d\u7136\u53c2\u6bd4\u4ecd\u6709\u5927\u4e8e\u4eff\u5236\u7684\u8d8b\u52bf\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n

<\/span><\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

<\/span><\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

<\/span><\/p>\n

\u3010\u836f\u7269\u6027\u8d28\u3011<\/span><\/strong><\/p>\n


<\/span><\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n
\n

\u9879\u76ee<\/span><\/strong><\/p>\n<\/td>\n

\n

\u4eff\u5236\uff1a\u30ca\u30eb\u30d5\u30e9\u30d5\u30a3\u30f3\u5869\u9178\u5869\u30ab\u30d7\u30bb\u30eb<\/span>2.5<\/span>\u03bc<\/span>g<\/span><\/p>\n<\/td>\n

\n

\u53c2\u6bd4\uff1a\u30ec\u30df\u30c3\u30c1\u30ab\u30d7\u30bb\u30eb<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5242\u91cf<\/span><\/strong><\/p>\n<\/td>\n

\n

2.5\u03bcg<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5904\u65b9\u5de5\u827a<\/span><\/strong><\/p>\n<\/td>\n

\n

\u5185\u5bb9\u7269\uff1a\u4e59\u9187\uff0c\u6ca1\u98df\u5b50\u9178\u4e19\u916f\uff0c\u4e2d\u94fe\u8102\u80aa\u9178\u7518\u6cb9\u4e09\u916f<\/span><\/p>\n

\u56ca\u58f3\uff1a\u660e\u80f6\uff0c\u7425\u73c0\u9178\u660e\u80f6\uff0c<\/span>D-<\/span>\u5c71\u68a8\u7cd6\u9187\uff0c\u7518\u6cb9\uff0c\u786b\u4ee3\u786b\u9178\u94a0\u6c34\u5408\u7269\uff0c\u4e8c\u6c27\u5316\u949b\uff0c\u5927\u8c46\u5375\u78f7\u8102\uff0c\u4e2d\u94fe\u8102\u80aa\u9178\u7518\u6cb9\u4e09\u916f<\/span><\/p>\n<\/td>\n

\n

\u5185\u5bb9\u7269\uff1a<\/span>PEG400<\/span>\uff0c\u786b\u4ee3\u786b\u9178\u94a0\u6c34\u5408\u7269<\/span><\/p>\n

\u56ca\u58f3\uff1a\u7425\u73c0\u9178\u660e\u80f6\uff0c\u660e\u80f6\uff0c\u7518\u6cb9\uff0c\u6c27\u5316\u949b<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

BCS<\/span><\/strong><\/p>\n<\/td>\n

\n

III<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

pKa<\/span><\/strong><\/p>\n<\/td>\n

\n

9.4<\/span>\uff0c<\/span>10.5<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u6eb6\u89e3\u5ea6<\/span><\/strong><\/p>\n<\/td>\n

\n

\u6613\u6eb6\u4e8e\u6c34<\/span><\/strong>\u548c\u7532\u9187\uff0c\u96be\u4ee5\u6eb6\u4e8e\u4e59\u9187\uff0c\u96be\u6eb6\u4e8e\u4e59\u9178\u4e59\u916f\u548c\u4e59\u919a\uff0c\u65e0\u660e\u663e<\/span>pH<\/span>\u4f9d\u8d56\u6027<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5438\u6536\u673a\u5236<\/span><\/strong><\/p>\n<\/td>\n

\n

P-gp<\/span>\u5e95\u7269\uff0c\u6e17\u900f\u6027\u8f83\u4f73\uff1b\u7ecf<\/span>P450<\/span>\u9176\u4ee3\u8c22\uff08\u53ef\u80fd\u5177\u6709\u809d\u9996\u8fc7\u6548\u5e94\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

PK<\/span><\/strong>\u53c2\u6570<\/span><\/strong><\/p>\n<\/td>\n

\n

BA=58%<\/span>\uff0c\u7ebf\u6027<\/span>PK<\/span>\uff1b\u5438\u6536\u4e0d\u53d7\u98df\u7269\u5f71\u54cd\uff0c\u534a\u8870\u671f<\/strong><\/span>9~14h<\/span><\/strong>\uff0c<\/span><\/strong>Tmax<\/sub>\u22483h<\/span><\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


<\/span><\/strong><\/p>\n

\u3010\u4e71\u5f39\u3011<\/span><\/strong><\/p>\n


<\/span><\/strong><\/p>\n

\uff08<\/span>1\uff09\u6eb6\u51fa\uff1a\u672c\u54c1\u5c5e\u8f6f\u80f6\u56ca\uff0c\u8f6f\u80f6\u56ca\u867d\u65e0\u56fa\u4f53\u836f\u7269\u6eb6\u51fa\u8fc7\u7a0b\uff0c\u4f46\u5d29\u89e3\u65f6\u95f4\u4e0d\u540c\u3001\u6eb6\u5a92\u9009\u62e9\u4e0d\u5f53\uff0c\u5f71\u54cd\u6cb9\u6ef4\u4e73\u5316\u3001\u80a0\u6e17\u900f\u3001\u6dcb\u5df4\u5438\u6536\u3002\u8d44\u6599\u672a\u516c\u5f00\u4ea7\u54c1\u7684\u5d29\u89e3\u65f6\u95f4\uff0c\u4e0d\u59a8\u7ed3\u5408\u5236\u5242\u5916\u89c2\uff08\u5927\u5c0f\u3001\u91cd\u91cf\u5747\u76f8\u5f53\uff09\u3001\u6eb6\u51fa\u66f2\u7ebf\uff08<\/span>5~10min\u5feb\u901f\u6eb6\u51fa\uff09\u63a8\u6d4b\uff0c\u4eff\u5236\u4ea7\u54c1\u4e0e\u539f\u7814\u4ea7\u54c1\u5d29\u89e3\u65f6\u9650\u5747\u4e3a<\/strong><\/span>5~10min<\/strong>\u3002\u56e0\u4e2d\u94fe\u7518\u6cb9\u4e09\u916f\u4e73\u5316\u3001\u6eb6\u4e8e\u6c34\u7684\u65f6\u95f4\u8f83<\/span>PEG400\u957f\uff0c\u6545\u9020\u6210\u4e24\u8005\u6eb6\u51fa\u5dee\u5f02\u3002<\/span><\/p>\n


<\/span><\/p>\n

\uff08<\/span>2\uff09<\/span>BE\uff1a\u672c\u54c1<\/span>Tmax<\/sub>\u2248<\/span>3h\uff0c\u63a8\u6d4b\u5438\u6536\u90e8\u4f4d\u5728\u5341\u4e8c\u6307\u80a0\u3001\u7a7a\u80a0\u4e0a\u7aef<\/strong>\uff1b\u534a\u8870\u671f<\/span>9~14h\uff0c\u6d88\u9664\u5bf9\u5438\u6536\u76f8\u7684\u5f71\u54cd\u5c0f\uff1b<\/span>BCS III\u7c7b\u4e14\u53ef\u5438\u6536\u540e\u53ef\u7ecf<\/span>P-gp\u5916\u6392\uff0c\u6e17\u900f\u662f<\/strong><\/span>BE<\/strong>\u7684\u9650\u901f\u6b65\u9aa4<\/span><\/strong>\u3002\u56e0\u6b64\uff0c\u5f71\u54cd\u672c\u54c1<\/span>BE\u6210\u529f\u7684\u5173\u952e\u56e0\u7d20\u662f\u4eff\u5236\u4ea7\u54c1\u4e0e\u539f\u7814\u4ea7\u54c1\u7684\u8f85\u6599\u5bf9\u836f\u7269\u7684\u5438\u6536\u7684\u5f71\u54cd\u662f\u5426\u4e00\u81f4<\/strong>\u3002\u539f\u7814\u4f7f\u7528\u7684<\/span>PEG\u5c5e\u4eb2\u6c34\u6027\u8f85\u6599\uff0c\u800c\u4eff\u5236\u4ea7\u54c1\u4f7f\u7528\u9971\u548c\u8102\u80aa\u9178\u7c7b\uff0c\u5c5e\u8102\u8d28\u5236\u5242\uff1b\u4e24\u8005\u4f53\u5185\u5438\u6536\u673a\u5236\u4e0d\u4e00\u81f4\u3002\u8102\u8d28\u5236\u5242\u53ef\u901a\u8fc7\u4fc3\u8fdb\u836f\u7269\u6dcb\u5df4\u5438\u6536\u3001\u80a0\u5438\u6536\u3001\u51cf\u5c11\u809d\u4ee3\u8c22\u4fc3\u8fdb\u5438\u6536<\/span>[1~3]<\/sup>\u3002<\/span>\u56e0\u6b64\uff0c\u7406\u8bba\u5206\u6790\u4eff\u5236\u4ea7\u54c1\u7684\u80a0\u6e17\u900f\u6027\u9ad8\u4e8e\u539f\u7814\u4ea7\u54c1\uff0c\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u53ef\u5f25\u8865\u6eb6\u51fa\u7684\u52a3\u52bf\u3002\u53e6\u5916\uff0c\u4f53\u5185\u80c3\u80a0\u6db2\u5b58\u5728\u8868\u9762\u6d3b\u6027\u6210\u5206\uff0c\u53ef\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u4eff\u5236\u4ea7\u54c1\u8102\u80aa\u9178\u7684\u4e73\u5316\u4fc3\u8fdb\u6eb6\u51fa\uff0c\u4ece\u800c\u4f7f\u4e24\u8005<\/span>BE\u7b49\u6548\u3002<\/span><\/p>\n


<\/span><\/p>\n

No.2\u2014\u2014<\/span>\u79d1\u7814\u836f\u4e1a\u7684\u820d\u66f2\u6797\u7247\u5242<\/span><\/strong><\/h2>\n

\u3010\u5173\u952e\u8bcd\u3011\u6eb6\u51fa\u884c\u4e3a\u3001\u5438\u6536\u901f\u5ea6<\/span><\/strong><\/p>\n

\u3010\u6eb6\u51fa\u66f2\u7ebf\u3011<\/span><\/strong>50rpm\u7684\u6eb6\u51fa\u66f2\u7ebf\u5747\u76f8\u4f3c\uff0c\u4ec5<\/span>100rpm 6.8<\/strong>\u4ecb\u8d28\u6eb6\u51fa\u4e0d\u76f8\u4f3c<\/span><\/strong>\uff1b\u4f46<\/span>50rpm\u7684\u6eb6\u51fa\u66f2\u7ebf\u51fa\u73b0\u4e86\u4f20\u8bf4\u4e2d\u7684\u5927\u5fcc\uff1a\u66f2\u7ebf\u4ea4\u53c9\u3001\u90e8\u5206\u65f6\u95f4\u70b9\u5dee\u5f02\u8f83\u5927\u3001\u6eb6\u51fa\u5e73\u53f0\u5dee\u5f02\uff1e<\/strong><\/span>10%<\/strong>\u3002<\/span><\/p>\n

 <\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n


<\/span><\/strong><\/p>\n

\u3010<\/span><\/strong>BE<\/strong>\u7ed3\u679c\u3011<\/span><\/strong>17\u4f8b\u7a7a\u8179\u5065\u5eb7\u5fd7\u613f\u8005<\/span>BE\u7ed3\u679c\u663e\u793a\u7b49\u6548\uff08\u4ecd\u5448\u73b0\u6eb6\u51fa\u4e00\u81f4\u7684\u8d8b\u52bf\uff09\u3002<\/span><\/p>\n

<\/span><\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n


<\/p>\n

\u3010\u836f\u7269\u6027\u8d28\u3011<\/span><\/strong><\/p>\n

<\/span>
<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n


<\/span><\/strong><\/p>\n

\u3010\u4e71\u5f39\u3011<\/span><\/strong><\/p>\n

\uff08<\/span>1\uff09\u6eb6\u51fa\uff1a\u63a8\u6d4b\u6eb6\u51fa\u66f2\u7ebf\u4ea4\u53c9\u7684\u539f\u56e0\uff1a\u4eff\u5236\u4ea7\u54c1\u5d29\u89e3\u66f4\u5feb\uff1b\u4f7f\u7528\u4e0d\u540c\u7684\u539f\u6599\u7c92\u5ea6\u3001\u5236\u7c92\u5de5\u827a\u3001\u6676\u578b\uff08\u4f7f\u7528\u4e9a\u7a33\u5b9a\u6027\u6676\u578b\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n

\uff08<\/span>2\uff09<\/span>BE\uff1a\u672c\u54c1<\/span>Tmax<\/sub><\/strong>\u2248<\/span><\/strong>5.5h<\/strong>\uff0c\u5438\u6536\u901f\u5ea6\u6162<\/strong>\uff0c\u63a8\u6d4b\u4e3b\u8981\u5728\u7a7a\u80a0\u4e0b\u7aef\u53ca\u56de\u80a0\u5438\u6536\uff1b\u91cd\u70b9\u5173\u6ce8<\/span>pH6.8\u66f2\u7ebf\u3002<\/span>pH6.8 100rpm\u867d\u4e0d\u76f8\u4f3c\uff0c<\/span>60min\u65f6\u4e24\u8005\u6eb6\u51fa\u8fd1\u5b8c\u5168\uff0c\u56e0\u5438\u6536\u901f\u5ea6\u6162\uff0c\u524d\u671f\u6eb6\u51fa\u5dee\u5f02\u5f71\u54cd\u5c0f\u3002\u540c\u6837\uff0c<\/span>50rpm\u65f6\u4e24\u8005\u6eb6\u51fa\u66f2\u7ebf\u867d\u4ea4\u53c9\u3001\u90e8\u5206\u65f6\u95f4\u70b9\u5dee\u5f02\u5927\uff0c\u4f46<\/span>60min\u540e\u4e24\u8005\u57fa\u672c\u4e00\u81f4\uff0c\u56e0\u6b64\u5f71\u54cd\u5c0f\u3002<\/span><\/p>\n

No.3\u2014\u2014<\/span>\u4e1c\u548c\u836f\u4e1a\u7684\u66ff\u7c73\u6c99\u5766\u6c22\u6c2f\u567b\u55ea\u7247<\/span><\/strong><\/h2>\n

\u3010\u5173\u952e\u8bcd\u3011\u590d\u65b9\u5236\u5242\u3001\u9ad8\u53d8\u5f02\u3001\u6e17\u900f\u6027<\/span><\/strong><\/p>\n

A<\/strong>\u3001\u66ff\u7c73\u6c99\u5766<\/span><\/strong><\/p>\n

\u3010\u6eb6\u51fa\u66f2\u7ebf\u3011<\/span><\/strong>pH7.5\u3001\u6c34\u4e2d\u6eb6\u51fa\u66f2\u7ebf\u4e0d\u76f8\u4f3c\uff0c\u5747\u6bd4\u53c2\u6bd4\u6eb6\u51fa\u5feb\uff0c<\/span>15min\u6eb6\u51fa\u5dee\u5f02\uff1e<\/span>15%\u3002<\/span><\/p>\n


<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n


<\/span><\/strong><\/p>\n

\u3010<\/span><\/strong>BE<\/strong>\u7ed3\u679c\u3011<\/span><\/strong>71\u4f8b\u7a7a\u8179\u5065\u5eb7\u5fd7\u613f\u8005<\/span>BE\u7ed3\u679c\u663e\u793a\u7b49\u6548\u3002<\/span><\/p>\n


<\/p>\n


<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n


<\/strong><\/p>\n

B<\/strong>\u3001\u6c22\u6c2f\u567b\u55ea<\/span><\/strong><\/p>\n

\u3010\u6eb6\u51fa\u66f2\u7ebf\u3011<\/span><\/strong>50rpm\u6240\u6709\u66f2\u7ebf\u5747\u4e0d\u76f8\u4f3c<\/span>\uff08\u5bf9\uff0c\u4f60\u53c8\u6ca1\u6709\u770b\u9519\uff09\uff0c<\/span><\/em>\u4eff\u5236\u4ea7\u54c1\u6bd4\u53c2\u6bd4\u5feb\u3002<\/span><\/p>\n


<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n


<\/span><\/strong><\/p>\n

\u3010<\/span><\/strong>BE<\/strong>\u7ed3\u679c\u3011<\/span><\/strong>24\u4f8b\u7a7a\u8179\u5065\u5eb7\u5fd7\u613f\u8005<\/span>BE\u7ed3\u679c\u663e\u793a\u7b49\u6548\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\"\u6eb6\u51fa\u4e0d\u76f8\u4f3cBE\u7b49\u6548\uff1f\u2014\u2014818\u90a3\u4e9b\u827a\u9ad8\u4eba\u80c6\u5927\u7684\u65e5\u672c\u4eff\u5236\u6848\u4f8b\"<\/p>\n

\u3010\u836f\u7269\u6027\u8d28\u3011<\/span><\/strong><\/p>\n


<\/span><\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n

<\/td>\n		\n

\u4eff\u5236\uff1a\u4e1c\u548c\u836f\u4e1a\u30c6\u30eb\u30c1\u30a2\u914d\u5408\u9320<\/span><\/strong> <\/span>BP<\/span><\/strong><\/p>\n<\/td>\n

\n

\u53c2\u6bd4\uff1a\u65e5\u672c\u5b89\u65af\u6cf0\u6765\u30df\u30b3\u30f3\u30d3\u914d\u5408\u9320<\/span><\/strong>BP<\/span><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

\u5242\u91cf<\/span><\/strong><\/p>\n<\/td>\n

\n

\u66ff\u7c73\u6c99\u5766<\/span>80mg<\/span>\uff0c\u6c22\u6c2f\u567b\u55ea<\/span>12.5 mg<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5904\u65b9\u5de5\u827a<\/span><\/strong><\/p>\n<\/td>\n

\n

\u8584\u819c\u5305\u8863\u7247<\/span><\/p>\n

\u7518\u9732\u9187\uff0c<\/span>HPC<\/span>\uff0c\u8461\u7532\u80fa\uff0c\u786c\u8102\u9178\u9541\uff0c<\/span>L-HPC<\/span>\uff0c<\/span>HPMC<\/span>\uff0c\u6c27\u5316\u949b\uff0c<\/span>PEG6000<\/span>\uff0c\u6ed1\u77f3\u7c89\uff0c\u9ec4\u6c27\u5316\u94c1<\/span><\/p>\n<\/td>\n

\n

\u53cc\u5c42\u7247\uff08\u65e0\u5305\u8863\uff09\uff1a\u4e00\u6b65\u5236\u7c92<\/span><\/p>\n

\u7518\u9732\u9187<\/span>259.5mg<\/span>\uff0c\u8461\u7532\u80fa<\/span> <\/span>80mg<\/span>\uff0c<\/span>MCC<\/span>\uff0c\u6cca\u6d1b\u6c99\u59c6<\/span><\/span>188<\/span>16mg<\/span>\uff0c<\/span>HPC 6mg<\/span>\uff0c\u786c\u8102\u9178\u9541\uff0c\u9ec4\u6c27\u5316\u94c1<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

BCS<\/span><\/strong><\/p>\n<\/td>\n

\n

\u66ff\u7c73\u6c99\u5766<\/span>BCS 2<\/span>\uff08<\/span>NICHD<\/span>\uff0c<\/span>FDA<\/span>\uff09\uff1b\u6c22\u6c2f\u567b\u55ea<\/span>BCS3\/4<\/span>\uff08<\/span>WHO\/NICHD<\/span>\uff0c<\/span>FDA<\/span>\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u6eb6\u89e3\u5ea6<\/span><\/strong><\/p>\n<\/td>\n

\n

1.<\/span>\u66ff\u7c73\u6c99\u5766\u5177\u6709\u591a\u6676\u578b\uff08<\/span>A+B<\/span>\u6df7\u5408\u7269\uff09\uff0c\u8461\u7532\u80fa\u4e0e\u66ff\u7c73\u6c99\u5766\u6eb6\u89e3\u6210\u76d0\u540e\u4e00\u6b65\u5236\u7c92\u6210\u65e0\u5b9a\u578b\uff1b\u5176\u6eb6\u89e3\u5ea6\u5177\u6709<\/span>pH<\/span>\u4f9d\u8d56\u6027\uff0c<\/span>pH3~9<\/span>\u4e0d\u6eb6\uff1a<\/span>pH1.2-1.5mg\/ml,pH4.5-0.001mg\/ml,pH7.5-0.015mg\/ml,<\/span>\u6c34<\/span>-0.007mg\/ml<\/span><\/p>\n

2.<\/span>\u6c22\u6c2f\u567b\u55ea\uff0c\u4e13\u5229\u9650\u5b9a\u6c22\u6c2f\u567b\u55ea\u539f\u6599\u7c92\u5ea6\uff0c\u5176\u6eb6\u89e3\u5ea6\u65e0\u660e\u663e<\/span>pH<\/span>\u4f9d\u8d56\u6027\uff1a<\/span>pH1.2-0.94mg\/ml,pH4.0-1.00mg\/ml,pH6.8-1.00mg\/ml,<\/span>\u6c34<\/span>-0.99mg\/ml<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

pKa<\/span><\/strong><\/p>\n<\/td>\n

\n

1.<\/span>\u66ff\u7c73\u6c99\u5766\uff1a<\/span>pKa1<\/span>\uff1d<\/span>3.5pKa2<\/span>\uff1d<\/span>4.1pKa3<\/span>\uff1d<\/span>6.0<\/span>\uff1b\u5f31\u78b1<\/span><\/p>\n

2.<\/span>\u6c22\u6c2f\u567b\u55ea\uff1a<\/span>pKa1 = 8.6,   pKa2 = 9.9<\/span>\uff0c\u5f31\u9178<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5438\u6536\u673a\u5236<\/span><\/strong><\/p>\n<\/td>\n

\n

1.<\/span>\u66ff\u7c73\u6c99\u5766\u88ab\u52a8\u5438\u6536\u4e3a\u4e3b\uff0c\u5438\u6536\u901f\u5ea6\u5feb\uff0c\u5168\u80a0\u9053\u5438\u6536\uff1b<\/span>P-gp<\/span>\u5e95\u7269\u3001\u6709\u673a\u9634\u79bb\u5b50\u8f6c\u8fd0\u591a\u80bd<\/span>OATP1B3<\/span>\u5e95\u7269\uff0c\u5f3a\u9996\u8fc7\u6548\u5e94\uff08\u90e8\u5206\u80a0\u4ee3\u8c22\uff0c\u5927\u90e8\u5206\u809d\u4ee3\u8c22\uff09\uff0c\u9ad8\u53d8\u5f02\u836f\u7269<\/strong><\/span><\/p>\n

2.<\/span>\u6c22\u6c2f\u567b\u55ea\u88ab\u52a8<\/span>\/<\/span>\u4e3b\u52a8\u5438\u6536\uff0c\u4e3b\u8981\u5728\u5341\u4e8c\u6307\u80a0\u548c\u7a7a\u80a0\u4e0a\u7aef\u5438\u6536\uff0c<\/span>P-gp<\/span>\u5e95\u7269<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

PK<\/span><\/strong>\u53c2\u6570<\/span><\/strong><\/p>\n<\/td>\n

\n

1,<\/span>\u66ff\u7c73\u6c99\u5766<\/span>BA=42~58%<\/span>\uff0c<\/span>40~160mg<\/span>\u5242\u91cf\u8303\u56f4\u5185\u975e\u7ebf\u6027<\/span>PK<\/span>\uff1b<\/span>Tma<\/sub>\u22481.1~1.3h<\/span><\/strong>\u3001<\/span><\/strong>T1\/2<\/sub>\u224821~24h<\/span><\/strong>\uff1b\u5438\u6536\u53d7\u98df\u7269\u5f71\u54cd\uff0c\u9910\u540e<\/span>tmax<\/span>\u5ef6\u8fdf\uff08<\/span>1.5<\/span>\u2192<\/span>2.50h<\/span>\uff09\uff0c<\/span>Cmax<\/span>\u548c<\/span>AUC 0-tz<\/span>\u5206\u522b\u964d\u4f4e<\/span>62%<\/span>\u548c<\/span>29-33%<\/span><\/p>\n

2.<\/span>\u6c22\u6c2f\u567b\u55ea<\/span>BA=60~80%<\/span>\uff0c\u7ebf\u6027<\/span>PK<\/span>\uff1b<\/span>Tmax<\/sub>\u22481.6~1.8h<\/span><\/strong>\u3001<\/span><\/strong>T1\/2<\/sub>\u22488h<\/span><\/strong>\uff1b\u98df\u7269\u53ef\u51cf\u5c11\u6c22\u6c2f\u567b\u55ea\u5438\u6536\uff08\u6ce8\uff1a\u53e6\u6709\u62a5\u5bfc\u98df\u7269\u589e\u52a0\u5355\u65b9\u7247\u5242\u5438\u6536\uff09\uff0c\u9910\u540e<\/span>tmax<\/sub><\/span>\u76f8\u4f3c\uff08<\/span>2.0<\/span>\u2192<\/span> <\/span>2.50h<\/span>\uff09\uff1b<\/span>Cmax<\/sub><\/span>\u548c<\/span>AUC0-tz<\/sub><\/span>\u5206\u522b\u964d\u4f4e<\/span>13~15%<\/span>\u548c<\/span>13%<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


<\/span><\/strong><\/p>\n

\u3010\u4e71\u5f39\u3011<\/span><\/strong>\u672c\u54c1\u5c5e\u53cc\u5c42\u7247\u590d\u65b9\u5236\u5242\u3002<\/span><\/p>\n

\uff08<\/span>1\uff09\u66ff\u7c73\u6c99\u5766\uff1a\u5177\u6709\u5f3a\u9996\u8fc7\u6548\u5e94\uff0c\u5c5e\u9ad8\u53d8\u5f02\u836f\u7269\uff1b<\/span>Tma<\/sub>\u22481.1~1.3h<\/strong>\uff0c<\/span>T1\/2<\/sub><\/strong>\u2248<\/span>21~24h\uff0c\u5438\u6536\u901f\u5ea6\u5feb\uff0c\u91cd\u70b9\u5173\u6ce8<\/span>pH1.2<\/strong>\u6eb6\u51fa\u66f2\u7ebf<\/span><\/strong>\uff0c<\/span>pH7.5\u3001\u6c34\u4e2d\u7684\u66f2\u7ebf\u5224\u65ad\u4ef7\u503c\u6709\u9650\u3002<\/span><\/p>\n


<\/span><\/p>\n

\uff08<\/span>2\uff09\u6c22\u6c2f\u567b\u55ea\uff1a\u6c22\u6c2f\u567b\u55ea<\/span>Tmax<\/sub>\u22481.6~1.8h<\/strong>\u3001<\/span><\/strong>T1\/2<\/sub>\u22488h<\/strong>\uff0c\u4e3b\u8981\u5728\u5341\u4e8c\u6307\u80a0\u548c\u7a7a\u80a0\u4e0a\u7aef\u5438\u6536\uff08\u8868<\/span>1\uff09\uff1b\u6e17\u900f\u6027\u4e2d\u7b49\uff0c\u5b58\u5728\u4e3b\u52a8\u5438\u6536\u673a\u5236\u3002\u7efc\u4e0a\uff0c\u53ef\u91cd\u70b9\u5173\u6ce8<\/span>pH1.2~4.0\u6eb6\u51fa\u66f2\u7ebf\u3002\u6e17\u900f\u6027\u662f\u51b3\u5b9a\u672c\u54c1\u5438\u6536\u9650\u901f\u6b65\u9aa4<\/strong>\uff0c\u6587\u732e<\/span>[5]<\/sup>\u62a5\u5bfc\u5176\u901f\u91ca\u5236\u5242\u3001\u53e3\u8154\u5d29\u89e3\u7247\uff0c\u5373\u4f7f\u6eb6\u51fa\u66f2\u7ebf\u4e0d\u76f8\u4f3c<\/span>BE\u7b49\u6548\uff08\u6ce8\uff1a\u6587\u4e2d<\/span>pH6.8\u66f2\u7ebf\u4e0d\u76f8\u4f3c\uff09\uff0c\u53ef\u8ba4\u4e3a\u6eb6\u51fa\u524d\u671f\u5f71\u54cd\u6709\u9650\u3002\u82e5\u5ffd\u7565\u524d<\/span>15min\u6eb6\u51fa\uff0c\u5219<\/span>pH4.0\u4ecb\u8d28<\/span>30min\u4e24\u8005\u6eb6\u51fa\uff1e<\/span>85%\uff0c\u5c5e\u5feb\u901f\u91ca\u653e\uff1b<\/span>pH1.2 15min\u540e\u66f2\u7ebf<\/span>f2<\/em>\u867d\u53ea\u6709<\/span>41\uff0c\u4f46\u6eb6\u51fa\u5dee\u5f02\uff1c<\/span>12%\u3002\u53e6\u4e00\u4e2a\u5927\u80c6\u7684\u63a8\u6d4b\u662f\uff0c\u66f2\u7ebf\u4e0d\u76f8\u4f3c\u53ef\u80fd\u662f\u7531\u4e8e\u6eb6\u51fa\u884c\u4e3a\u5f15\u8d77\u7684\uff0c\u5728\u4f53\u5185\u53ef\u6d88\u9664\u3002\u5728\u6eb6\u51fa\u8fc7\u7a0b\u4e2d\uff0c\u6c22\u6c2f\u567b\u55ea\u5c42\u5148\u4e8e\u66ff\u7c73\u6c99\u5766\u5c42\u5d29\u89e3\uff08<\/span>TW200806288A\uff09\uff0c\u800c\u66ff\u7c73\u6c99\u5766\u5728<\/span>pH4.0\u5de6\u53f3\u6eb6\u51fa\u53d1\u7c98\uff0c\u6d46\u6cd5\u5177\u6709\u7684\u7f3a\u9677\u5bb9\u6613\u9020\u6210\u5e95\u90e8\u9525\u5f62\u5806\u79ef\uff0c\u52a0\u4e4b\u6295\u7247\u7684\u5dee\u5f02\uff0c\u4f7f\u6c22\u6c2f\u567b\u55ea\u4e0d\u6613\u6269\u6563\u3001\u6eb6\u51fa\u5dee\u5f02\u5927\u3002\u4eff\u5236\u4e0e\u539f\u7814\u5382\u5bb6\u5236\u5907\u6c22\u6c2f\u567b\u55ea\u5c42\u5904\u65b9\u4e0d\u4e00\u81f4\uff0c\u4eff\u5236\u5382\u5bb6\u672a\u52a0\u5fae\u6676\u7ea4\u7ef4\u7d20\uff0c\u53ef\u80fd\u4f7f\u7528\u5d29\u89e3\u80fd\u529b\u66f4\u5f3a\u7684<\/span>L-HPC\u3002\u6b64\u79cd\u60c5\u51b5\u4e0b\uff0c\u4e24\u8005\u7684\u5dee\u5f02\u53e3\u670d\u540e\u53ef\u7531\u4e8e\u80c3\u80a0\u9053\u5177\u6709\u673a\u68b0\u4f5c\u7528\u800c\u6d88\u9664\u3002\u6b64\u5916\uff0c\u53c2\u6bd4\u4f7f\u7528\u5177\u6709\u6291\u5236<\/span>P-gp\u5916\u6392\u7684\u6cca\u6d1b\u6c99\u59c6<\/span>188\uff0c\u53ef\u80fd\u4e5f\u662f\u4fc3\u8fdb\u5438\u6536\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8868<\/span>1 \u6587\u732e\u62a5\u5bfc\u7684\u6c22\u6c2f\u567b\u55ea\u5728\u5404\u90e8\u4f4d\u5438\u6536\u7684\u6570\u636e<\/span>[4]<\/sup><\/p>\n


<\/sup><\/p>\n

\n

\u540e\u8bb0\uff1a\u4e0a\u8ff0\u54c1\u79cd\u7b14\u8005\u5747\u65e0\u5b9e\u6218\u7ecf\u9a8c\uff0c\u5747\u4e3a\u4e2a\u4eba\u5206\u6790\u4e14\u4e0d\u514d\u6709\u9a6c\u540e\u70ae\u5acc\u7591\uff08\u8bdd\u8bf4\u8fd9\u6837\u7684\u66f2\u7ebf\u6211\u4eec\u771f\u4e0d\u6562\u4e0aBE<\/em>\uff09\uff1b\u758f\u6f0f\u4e4b\u5904\u6b22\u8fce\u5404\u4f4d\u7559\u8a00\u8ba8\u8bba\u3002<\/span><\/p>\n


<\/span><\/h1>\n

\u3010\u53c2\u8003\u6587\u732e\u3011<\/span><\/h1>\n


<\/span><\/p>\n

[1]Effectof short\u2010<\/span>, medium\u2010<\/span>, and long\u2010<\/span>chain fatty acid\u2010<\/span>based vehicles on the absolute oral bioavailabilityand intestinal lymphatic transport of halofantrine and assessment of massbalance in lymph\u2010<\/span>cannulated and non\u2010<\/span>cannulated rats<\/span><\/p>\n

[2]Formulation and Intestinal AbsorptionEnhancement Evaluation of Water-in-Oil Microemulsions IncorporatingMedium-Chain Glycerides<\/span><\/p>\n

[3]\u8102\u8d28\u5236\u5242\u5bf9\u96be\u6eb6\u6027\u836f\u7269\u8334\u4e09\u786b\u53e3\u670d\u5438\u6536\u4e0e\u4ee3\u8c22\u7684\u5f71\u54cd<\/span><\/span><\/p>\n

[4]Absorption, metabolism, and excretion ofhydrochlorothiazide<\/span><\/p>\n

<p style=”font: 17px\/27.2px -apple-system-font,BlinkMacSystemFont,” border-box=”” break-word=”” yahei=”” sans=”” helvetica=”” 255);”=”” 255,=”” rgb(255,=”” 51,=”” rgb(51,=”” ui”,”microsoft=”” gb”,”microsoft=”” sc”,”hiragino=”” neue”,”pingfang=”” 0px=””>[5]Application of the BCS biowaiver approach toassessing bioequivalence of orally disintegrating tablets with immediaterelease formulations<\/span><\/p>\n

<\/mpcps><\/section>\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u5916\u8d44\u5927\u578b\u5236\u836f\u516c\u53f8\u6280\u672f\u3001\u7814\u53d1\u3001\u8d28\u91cf\u603b\u76d1\uff0c\u9a8c\u8bc1\u7ba1\u7406\u8d44\u6df1\u4e13\u5bb6\uff0c\u591a\u5bb6\u5236\u836f\u516c\u53f8\u987e\u95ee\uff0c\u836f\u5b66\u7855\u58eb\u3002\u56fd\u5bb6\u5de5\u827a\u6838\u5bf9\u672a\u96e8\u7ef8\u7f2a\u4e4b\u9645\uff0c […]<\/p>\n","protected":false},"author":1,"featured_media":37016,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/37015"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=37015"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/37015\/revisions"}],"predecessor-version":[{"id":37041,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/37015\/revisions\/37041"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/37016"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=37015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=37015"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=37015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}