{"id":38372,"date":"2018-09-06T01:00:00","date_gmt":"2018-09-17T06:20:11","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e3%80%90%e7%bb%8f%e5%85%b8%e5%9b%9e%e9%a1%be%e3%80%91%e7%ac%ac%e4%b8%80%e4%b8%aapd-1%e6%8a%97%e4%bd%93%ef%bc%9anivolumab%e7%9a%84%e5%bc%80%e5%8f%91%e6%95%85%e4%ba%8b\/"},"modified":"2018-09-17T14:20:12","modified_gmt":"2018-09-17T06:20:12","slug":"%e3%80%90%e7%bb%8f%e5%85%b8%e5%9b%9e%e9%a1%be%e3%80%91%e7%ac%ac%e4%b8%80%e4%b8%aapd-1%e6%8a%97%e4%bd%93%ef%bc%9anivolumab%e7%9a%84%e5%bc%80%e5%8f%91%e6%95%85%e4%ba%8b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/38372\/","title":{"rendered":"\u3010\u7ecf\u5178\u56de\u987e\u3011\u7b2c\u4e00\u4e2aPD-1\u6297\u4f53\uff1aNivolumab\u7684\u5f00\u53d1\u6545\u4e8b"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><br  \/><\/p>\n<h2 class=\"rich_media_title\" style=\"margin-bottom: 14px;font-size: 22px;line-height: 1.4;color: rgb(51, 51, 51);font-family: 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!important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;word-wrap: break-word !important;\">\n<section style=\"margin-top: -3em;margin-bottom: 0.2em;padding-right: 3.3em;max-width: 100%;box-sizing: border-box;border-radius: 1.5em;word-wrap: break-word !important;\">\n<section style=\"padding-right: 15px;padding-left: 10px;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;color: rgb(208, 166, 241);font-size: 14px;text-align: center;line-height: 1;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"><span style=\"color: rgb(255, 255, 255);font-size: 14px;\">\u672c\u6587\u7531\u7f8e\u4e2d\u836f\u6e90\u7f16\u8f91\u3002<\/span><br  \/><img   width=\"100%\"   class=\"\" style=\"box-sizing: border-box;float: left;display: inline-block;vertical-align: middle;background-color: rgb(249, 110, 87);width: 677px;word-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537165212.png\" alt=\"\u3010\u7ecf\u5178\u56de\u987e\u3011\u7b2c\u4e00\u4e2aPD-1\u6297\u4f53\uff1aNivolumab\u7684\u5f00\u53d1\u6545\u4e8b\" title=\"\u3010\u7ecf\u5178\u56de\u987e\u3011\u7b2c\u4e00\u4e2aPD-1\u6297\u4f53\uff1aNivolumab\u7684\u5f00\u53d1\u6545\u4e8b\"  \/><span style=\"background-color: rgba(255, 255, 255, 0.498039);color: rgb(13, 14, 13);text-align: justify;\"><br  \/><\/span><\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"><span style=\"background-color: rgba(255, 255, 255, 0.498039);color: rgb(13, 14, 13);text-align: justify;\"><br  \/><\/span><\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"><span style=\"background-color: rgba(255, 255, 255, 0.498039);color: rgb(13, 14, 13);text-align: justify;\">\u968f\u7740PD-1\u6297\u4f53\u836f\u7269\u6b27\u72c4\u6c83(\u82f1\u6587\u5546\u54c1\u540d: Opdivo, \u82f1\u6587\u901a\u7528\u540d:Nivolumab)\u5df2\u4e8e8\u670828\u53f7\u5728\u4e2d\u56fd\u8fdb\u5165\u94fa\u8d27\u9500\u552e\u9636\u6bb5\uff0c\u56fd\u5185\u80ba\u764c\u60a3\u8005\u7ec8\u4e8e\u53ef\u4ee5\u4f7f\u7528\u5230\u8fd9\u4e00\u9769\u547d\u6027\u7684\u6297\u764c\u836f\u7269\u3002\u4f5c\u8005\u7531\u4e8e\u5de5\u4f5c\u539f\u56e0\uff0c\u8fc7\u53bb\u4e00\u5e74\u591a\u91cc\u9605\u8bfb\u4e86\u4e00\u4e9b\u8fd9\u4e2a\u836f\u7269\u7684\u5f00\u53d1\u5386\u7a0b\u7684\u6587\u732e\u3002\u53d1\u73b0\u4e4b\u524d\u4e2d\u6587\u62a5\u9053\u4e2d\uff0c\u591a\u5c11\u6709\u4e9b\u548c\u4f5c\u8005\u4e86\u89e3\u5230\u7684\u4e8b\u5b9e\u6709\u6240\u51fa\u5165\uff0c\u7279\u64b0\u6b64\u6587\uff0c\u4f9b\u5927\u5bb6\u8ba8\u8bba\u3002<\/span><\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 8px;margin-bottom: 8px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-top: 1.5em;padding-bottom: 3em;max-width: 100%;box-sizing: border-box;width: 677px;background-color: rgb(204, 249, 248);box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-width: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 0.3em 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;height: 2em;background-color: rgb(249, 110, 87);color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u7b2c\u4e00\u90e8\u5206\uff1aPD-1\u7684\u53d1\u73b0\u548c\u529f\u80fd\u9274\u5b9a<\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;height: 2em;width: 0.5em;vertical-align: top;border-left: 0.5em solid rgb(249, 110, 87);word-wrap: break-word !important;border-top: 1em solid transparent !important;border-bottom: 1em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"padding: 3px 10px;max-width: 100%;box-sizing: border-box;display: inline-block;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;background-color: rgba(255, 255, 255, 0.498039);display: inline-block;color: rgb(13, 14, 13);text-align: justify;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">1992\u5e74\uff0c\u65e5\u672c\u79d1\u5b66\u5bb6TasukuHonjo&nbsp;(\u672c\u5eb6\u4f51) \u4ece\u5c0f\u9f20\u4e0a\u5206\u79bb\u3001\u9274\u5b9a\u4e86PD-1\u57fa\u56e0\uff0c\u5f97\u5230\u4e86\u5c0f\u9f20PD-1\u86cb\u767d\uff0c\u8fd9\u4e00\u6210\u679c\u53d1\u8868\u57281992\u5e74\u7684EMBO\u6742\u5fd7\u4e0a(1)\u3002\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\uff0c\u672c\u5eb6\u4f51\u8ba4\u4e3a\u5c5e\u4e8e\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf\u7684PD-1\u7684\u6d3b\u5316\u4f1a\u5bfc\u81f4T\u7ec6\u80de\u7684\u51cb\u4ea1\uff0c\u8fd9\u4e5f\u662fPD-1\u86cb\u767d\u7684\u547d\u540d\u7531\u6765\uff08Programmed Death-1\uff09\u3002\u672c\u5eb6\u4f51\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\u516c\u5e03\u4e86PD-1\u86cb\u767d\u7684\u5e8f\u5217\uff0c\u968f\u540e\u51e0\u5e74\u63a5\u8fde\u53d1\u8868\u4e86\u4e00\u7cfb\u5217\u7814\u7a76PD-1\u7684\u6210\u679c\uff0c\u59821994\u5e74\u4ed6\u627e\u5230\u4e86\u4eba\u7c7bPD-1\u57fa\u56e0\u548c\u86cb\u767d\uff082\uff09\uff0c\u5e76\u57281999\u5e74\u9996\u5148\u63d0\u51faPD-1\u662f\u4e00\u4e2a\u514d\u75ab\u7cfb\u7edf\u7684\u8d1f\u8c03\u63a7\u56e0\u5b50\uff083\uff09\u3002\u8fd9\u4e00\u6210\u679c\u5728\u5f53\u65f6\u5e76\u672a\u5f15\u8d77\u5b66\u754c\u592a\u591a\u91cd\u89c6\uff0c\u5c31\u8fde\u672c\u5eb6\u4f51\u672c\u4eba\u4e5f\u662f\u4ee5B\u7ec6\u80de\u7684\u53d1\u80b2\u548c\u529f\u80fd\u4f5c\u4e3a\u81ea\u5df1\u7684\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">2000\u5e74\uff0c\u5728\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute, DFCI\uff0c\u96b6\u5c5e\u4e8e\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\uff09\u5de5\u4f5c\u7684Gordon Freeman\u548c\u672c\u5eb6\u4f51\u4f5c\u4e3a\u7b2c\u4e00\u4f5c\u8005\u548c\u901a\u8baf\u4f5c\u8005\uff0c\u5171\u540c\u9610\u8ff0\u4e86PD-1\/PD-L1\u5bf9\u4eba\u4f53T\u7ec6\u80de\u7684\u8c03\u63a7\u4f5c\u7528\uff0c\u8fd9\u4e00\u9886\u57df\u624d\u9010\u6e10\u5f15\u8d77\u91cd\u89c6\uff084\uff09\u3002\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\uff0cFreeman\u7b49\u4eba\u4e0d\u4ec5\u53d1\u73b0\u4e86\u5c5e\u4e8eB7\u86cb\u767d\u5bb6\u65cf\u7684PD-L1\u86cb\u767d\u662fPD-1\u7684\u914d\u4f53\uff0c\u8fd8\u9996\u5148\u8bc1\u660e\u4e86 PD-L1\u901a\u8fc7\u7ed3\u5408PD-1\uff0c\u6291\u5236\u4e86T\u7ec6\u80de\u7684\u589e\u6b96\u548c\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u529f\u80fd\u3002Freeman\u5173\u6ce8\u5230PD-1\u5e76\u975e\u5076\u7136\uff0c\u4ed6\u548c\u59bb\u5b50Arlene Sharpe\u4e00\u76f4\u4ece\u4e8bB7\u86cb\u767d\u5bb6\u65cf\u7684\u7814\u7a76\u3002\u4ed6\u4eec\u5148\u524d\u5c31\u901a\u8fc7\u751f\u7269\u4fe1\u606f\u5b66\u7684\u529e\u6cd5\u627e\u5230\u4e86\u5f88\u591a\u548cB7\u86cb\u767d\u57fa\u56e0\u76f8\u4f3c\u7684B7\u86cb\u767d\u5bb6\u65cf\u6210\u5458\u3002\u6839\u636eCTLA-4\u86cb\u767d\u4f1a\u548cB7\u5bb6\u65cf\u7684B7-1\u3001B7-2\u86cb\u767d\u7ed3\u5408, PD-1\u86cb\u767d\u53c8\u548cCTLA-4\u7ed3\u6784\u6709\u7c7b\u4f3c\u7247\u6bb5\uff0c\u540c\u5c5e\u4e00\u4e2a\u86cb\u767d\u5bb6\u65cf\u7b49\u5df2\u77e5\u4fe1\u606f\uff0cFreeman\u63a8\u6d4b\u81ea\u5df1\u53d1\u73b0\u7684B7\u86cb\u767d\u5bb6\u65cf\u4e2d\uff0c\u53ef\u80fd\u6709PD-1\u7684\u914d\u4f53\u3002\u5f53\u65f6PD-1\u5c1a\u672a\u6210\u4e3a\u70ed\u95e8\u7814\u7a76\u9886\u57df\uff0c\u6ca1\u6709\u5546\u4e1a\u5316\u7684PD-1\u86cb\u767d\u4f9b\u5b9e\u9a8c\u7528\uff0cFreeman\u4e8e\u662f\u548c\u672c\u5eb6\u4f51\u5408\u4f5c\uff0c\u5c31\u6b64\u53d1\u73b0\u4e86PD-L1\u548cPD-1\u5728\u514d\u75ab\u7cfb\u7edf\u91cc\u7684\u8d1f\u8c03\u63a7\u529f\u80fd\u3002Gordon Freeman 79\u5e74\u54c8\u4f5b\u535a\u58eb\u6bd5\u4e1a\u540e\u5c31\u52a0\u5165\u4e86DFCI\uff0c\u4ece\u535a\u58eb\u540e\u505a\u8d77\u3002\u672c\u5eb6\u4f511984\u5e74\u5f00\u59cb\u5c31\u5728\u4e1c\u4eac\u5927\u5b66\u4efb\u804c\uff0c\u5148\u524d\u4e2d\u6587\u62a5\u9053\u91cc\u6709\u4e0d\u5c11\u8bf4Gordon Freeman\u662f\u672c\u5eb6\u4f51\u7684\u535a\u58eb\u540e\uff0c\u8fd9\u4e2a\u8bf4\u6cd5\u5e94\u4e0d\u662f\u4e8b\u5b9e\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u534e\u88d4\u5b66\u8005\u9648\u5217\u5e73\u6559\u6388\u5f53\u65f6\u4e5f\u4ece\u4e8bB7\u5bb6\u65cf\u86cb\u767d\u7684\u7814\u7a76\uff0c\u901a\u8fc7\u548cFreeman\u7c7b\u4f3c\u7684\u751f\u7269\u4fe1\u606f\u5b66\u65b9\u6cd5\uff0c\u4ed6\u4e8e1999\u5e7412\u6708\u9996\u5148\u53d1\u8868\u4e86PD-L1\u7684\u57fa\u56e0\u53ca\u86cb\u767d\u5e8f\u5217(5)\uff0c\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\uff0c\u9648\u5217\u5e73\u4ee5B7H1\u79f0\u547cPD-L1\u86cb\u767d\u3002\u9057\u61be\u7684\u662f\u9648\u5217\u5e73\u6ca1\u6709\u627e\u5230B7H1\u7684\u914d\u4f53\uff0c\u800c\u4e14\u6807\u9898\u4e2d\u8ba4\u4e3aB7H1\u662f\u5171\u523a\u6fc0T\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u8fd9\u548c\u540e\u6765\u591a\u6570\u4eba\u7684\u8ba4\u77e5\u7565\u6709\u4e0d\u540c\u3002\u9648\u5217\u5e73\u7684\u6587\u7ae0\u6bd4Freeman\u65e910\u4e2a\u6708\u516c\u5e03\u3002Freeman\u7684\u76f8\u5173\u4e13\u5229\u4e8e1999\u5e748\u6708\u63d0\u4ea4\uff0c\u6bd4\u9648\u5217\u5e73\u65e93\u4e2a\u6708\uff0c\u5728\u8fd9\u4e2a\u4e13\u5229\u4e2dFreeman\u4e5f\u516c\u5e03\u4e86PD-L1\u7684\u5e8f\u5217\uff0c\u53ef\u4ee5\u8ba4\u4e3a\u9648\u5217\u5e73\u548cFreeman\u51e0\u4e4e\u540c\u65f6\u53d1\u73b0\u4e86PD-L1\u86cb\u767d\u3002\u540e\u6765\u9648\u5217\u5e73\u4e8e2002\u5e74\u53d1\u8868\u6587\u7ae0\uff0c\u6307\u51fa\u5927\u591a\u6570\u80bf\u7624\u7ec6\u80de\u901a\u8fc7\u8868\u8fbePD-L1\u5b9e\u73b0\u514d\u75ab\u9003\u9038\uff086\uff09\uff0c\u8fd9\u4e3a\u5f00\u53d1PD-1\/PD-L1\u836f\u7269\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u63d0\u4f9b\u4e86\u91cd\u8981\u7406\u8bba\u4f9d\u636e\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u5728\u53d1\u73b0PD-1\/PD-L1\u901a\u8def\u5bf9T\u7ec6\u80de\u6709\u8d1f\u8c03\u63a7\u4f5c\u7528\u540e\uff0c\u5f53\u65f6\u79d1\u5b66\u5bb6\u4eec\u666e\u904d\u8ba4\u4e3a\u8fd9\u6761\u901a\u8def\u53ef\u80fd\u7528\u4e8e\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u836f\u7269\u7684\u5f00\u53d1\uff0c2001\u5e746\u6708\u5de6\u53f3\uff0c\u672c\u5eb6\u4f51\u4e0e\u5c0f\u91ce\u5236\u836f(ono pharmaceutical)\u4e00\u8d77\u63d0\u4ea4\u4e86\u4e00\u9879\u56fd\u9645\u4e13\u5229\uff1asubstance specific to human PD-1(7)\u3002\u5728\u8fd9\u4e2a\u4e13\u5229\u4fdd\u62a4\u4e0b\uff0c\u4efb\u4f55\u7269\u8d28\uff0c\u53ea\u8981\u7279\u5f02\u6027\u4e0e\u4ebaPD-1\u86cb\u767d\u7ed3\u5408\uff0c\u5c31\u4fb5\u72af\u4e86\u672c\u5eb6\u4f51\u548c\u5c0f\u91ce\u5236\u836f\u7684\u4e13\u5229\u3002\u8fd9\u4e2a\u4e13\u5229\u5728\u4eca\u5929\u53ef\u80fd\u4e0d\u4f1a\u88ab\u6279\u51c6\uff1a\u4e13\u5229\u7684\u5185\u5bb9\u4e3b\u8981\u662fPD-1\u7684\u57fa\u56e0\u548c\u86cb\u767d\u5e8f\u5217\uff0c\u6ca1\u6709\u5217\u51fa\u8bc1\u636e\u8bc1\u660e\u963b\u65adPD-1\u53ef\u4ee5\u7528\u4f5c\u514d\u75ab\u7597\u6cd5\u3002\u8fd9\u4e2a\u4e13\u5229\u7684\u5f71\u54cd\uff0c\u968f\u540e\u8fd8\u4f1a\u63d0\u5230\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 0.3em 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;height: 2em;background-color: rgb(249, 110, 87);color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u7b2c\u4e8c\u90e8\u5206\uff1aMedarex\u7684\u7814\u53d1\u8fc7\u7a0b<\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;height: 2em;width: 0.5em;vertical-align: top;border-left: 0.5em solid rgb(249, 110, 87);word-wrap: break-word !important;border-top: 1em solid transparent !important;border-bottom: 1em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"padding: 3px 10px;max-width: 100%;box-sizing: border-box;display: inline-block;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;background-color: rgba(255, 255, 255, 0.498039);display: inline-block;color: rgb(13, 14, 13);text-align: justify;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">2001\u5e74\u521d\uff0c\u738b\u5e38\u7389\u4eceChiron\u516c\u53f8\u4f5c\u4e3a\u7814\u53d1\u79d1\u5b66\u5bb6\u52a0\u5165Medarex\u516c\u53f8\uff0c\u5728Chiron\u671f\u95f4\uff0c\u738b\u5e38\u7389\u7814\u53d1\u4e86CD-40\u6297\u4f53\uff0c\u8fd9\u4e2a\u4ea7\u54c1\u4eca\u5929\u8fd8\u5728\u8bfa\u534e\u516c\u53f8\u7684\u5f00\u53d1\u7ba1\u7ebf\u91cc\u3002\u6b64\u65f6Medarex\u7684CTLA-4\u6297\u4f53\u5f00\u53d1\u5df2\u8fdb\u5165\u540e\u671f\uff0c\u516c\u53f8\u5f00\u59cb\u8003\u8651\u540e\u7eed\u9879\u76ee\u3002\u57fa\u4e8e\u4e0b\u8ff0\u51e0\u70b9\u539f\u56e0\uff0cMedarex\u7684\u5f00\u53d1\u56e2\u961f\u9009\u4e2d\u4e86PD-1\/PD-L1\u4f5c\u4e3a\u65b0\u9776\u70b9\u5f00\u53d1\u80bf\u7624\u514d\u75ab\u836f\u7269\uff1a<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">PD-1\u548cCTLA-4\u540c\u5c5e\u4e00\u4e2a\u86cb\u767d\u5bb6\u65cf\uff0c\u5f00\u53d1\u540c\u7c7b\u4ea7\u54c1\u5bf9Medarex\u8fd9\u6837\u7684\u5c0f\u578b\u516c\u53f8\u6765\u8bf4\u6216\u8bb8\u80fd\u964d\u4f4e\u7cfb\u7edf\u6027\u98ce\u9669\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u672c\u5eb6\u4f51\u4e8e1999\u5e74\u7684\u6587\u7ae0\uff083\uff09\u6307\u51faPD-1 \u6572\u9664\u540e\u7684\u5c0f\u9f20\u4f1a\u51fa\u73b0\u4e00\u4e9b\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u75c7\u72b6\uff0c\u5728\u6709\u4e9b\u9f20\u7cfb\u91cc\u8868\u73b0\u4e3a\u7ea2\u6591\u72fc\u75ae\uff0c\u6709\u4e9b\u5219\u8868\u73b0\u4e3a\u5fc3\u808c\u708e\uff08\u5fc3\u808c\u708e\u8fd9\u4e00\u526f\u4f5c\u7528\u65e5\u540e\u5728\u63a5\u53d7PD-1\u6297\u4f53\u6cbb\u7597\u7684\u75c5\u4eba\u8eab\u4e0a\u4e5f\u51fa\u73b0\u8fc7\uff09\u3002\u4f46\u53d1\u75c5\u8f83\u665a\uff0c\u6ca1\u6709\u50cfCTLA-4\u6572\u9664\u5c0f\u9f20\u51fa\u751f\u540e\u4e00\u6708\u5185\u5f88\u5feb\u6b7b\u4ea1\u3002\u8bc1\u660ePD-1\/PD-L1\u901a\u8def\u4e0e\u4f53\u5185\u514d\u75ab\u8c03\u8282\u6709\u5173\u7cfb\uff0c\u4f46\u526f\u4f5c\u7528\u53ef\u80fd\u8f83\u4f4e\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">PD-1\/PD-L1\u901a\u8def\u662f\u4e00\u4e2a\u8d1f\u8c03\u63a7\u56e0\u5b50\uff0c\u5f53\u65f6\u591a\u6570\u7684\u514d\u75ab\u7597\u6cd5\u7c7b\u65b0\u836f\u9879\u76ee\u662f\u6fc0\u6d3b\u514d\u75ab\u7ec6\u80de\u4e0a\u7684\u9776\u70b9\u86cb\u767d\u4e3a\u76ee\u7684\uff0c\u6bd4\u5982IL-2\u3001CD40\u6297\u4f53\u30014-1BB\u6297\u4f53\u7b49\u3002Medarex\u7684\u7814\u53d1\u56e2\u961f\u8ba4\u4e3a\uff0c\u523a\u6fc0\u514d\u75ab\u7ec6\u80de\u7684\u836f\u7269\u5c31\u50cf\u8f70\u6cb9\u95e8\uff0c\u4e34\u5e8a\u5f00\u53d1\u7684\u98ce\u9669\u5f88\u9ad8\uff1a\u96be\u4ee5\u63a7\u5236\u6bd2\u6027\u3002\u800c\u8d1f\u8c03\u63a7\u56e0\u5b50\u5c31\u50cf\u8e29\u5239\u8f66\uff0c\u8fd9\u7c7b\u56e0\u5b50\u5f80\u5f80\u53ea\u5b58\u5728\u4e8e\u5df2\u6fc0\u6d3b\u7684T\u7ec6\u80de\u91cc\uff0c\u6bd4\u5982\u6b63\u5e38\u7684T\u7ec6\u80de\u4e0d\u8868\u8fbePD-1\uff0c\u6bd2\u6027\u76f8\u5bf9\u8f83\u5c0f\u3002\u8fd9\u4e00\u89c2\u70b9\u5728\u540e\u7eed\u7684\u4e34\u5e8a\u4e0a\u4e5f\u5f97\u5230\u4e86\u9a8c\u8bc1\uff1a4-1BB\u6297\u4f53\u548cCD40\u6297\u4f53\u7684\u6bd2\u6027\u90fd\u592a\u5f3a\uff0c\u5f88\u96be\u63a7\u5236\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u5341\u591a\u5e74\u540e\u56de\u8fc7\u5934\u770b\uff0c\u5f53\u65f6Medarex\u5728\u8fd9\u4e2a\u9879\u76ee\u4e0a\u627f\u62c5\u4e86\u5de8\u5927\u7684\u98ce\u9669\uff1aPD-1\u4e0d\u662f\u7814\u7a76\u7684\u70ed\u70b9\uff0c\u9664\u4e86\u672c\u5eb6\u4f51\u56e2\u961f\u7684\u6210\u679c\u5916\u6ca1\u6709\u4ec0\u4e48\u6587\u732e\u548c\u6570\u636e\u63d0\u4f9b\u7406\u8bba\u652f\u6301\u3002Medarex\u5728\u7acb\u9879\u548c\u5f00\u53d1\u65f6\u4e5f\u6ca1\u6709\u5f97\u5230\u4efb\u4f55\u5916\u90e8\u4eba\u5458\u7684\u534f\u52a9\u548c\u6307\u5bfc\uff0c\u4ed6\u4eec\u7acb\u9879\u65f6\u751a\u81f3\u4e0d\u77e5\u9053\u672c\u5eb6\u4f51\u5df2\u7ecf\u7533\u8bf7\u4e86\u5173\u4e8ePD-1\u7684\u4e13\u5229\u3002Medarex\u5bf9PD-1\u7684\u8ba4\u8bc6\u4e5f\u6709\u4e00\u5b9a\u5c40\u9650\u6027\uff0c\u5e76\u6ca1\u6709\u9884\u6d4b\u5230PD-1\u6297\u4f53\u4f1a\u6210\u4e3a\u65b0\u4e00\u4ee3\u5e7f\u8c31\u6027\u3001\u9769\u547d\u6027\u7684\u6297\u764c\u836f\u7269\u3002\u8fd9\u4e5f\u57cb\u4e0b\u4e86\u65e5\u540e\u51fa\u552e\u81ea\u5df1\u7684\u79cd\u5b50\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u9664\u6b64\u4ee5\u5916\uff0c\u5f53\u65f6\u8be5\u9879\u76ee\u7684\u7814\u7a76\u6761\u4ef6\u4e0d\u5145\u5206\uff0c\u6240\u6709\u7684\u5b9e\u9a8c\u6750\u6599\u90fd\u8981\u9760Medarex\u56e2\u961f\u81ea\u5df1\u89e3\u51b3\u3002\u738b\u5e38\u7389\u5e26\u9886\u7684\u56e2\u961f\u542f\u52a8\u8fd9\u4e2a\u9879\u76ee\u65f6\uff0cPD-1\uff0cPD-L1, PD-L2\u8fd9\u4e09\u4e2a\u9776\u70b9\u86cb\u767d\u90fd\u8981\u81ea\u5df1\u52a8\u624bPCR\u514b\u9686\u57fa\u56e0\u5e76\u8868\u8fbe\u86cb\u767d\uff0c\u800c\u65e0\u6cd5\u5916\u8d2d\u3002\u5f53\u65f6\u5f88\u591a\u5b9e\u9a8c\u6761\u4ef6\u4e5f\u4e0d\u6210\u719f\uff0c\u9700\u8981\u5728\u5b9e\u8df5\u4e2d\u6478\u7d22\uff0c\u6700\u5148\u653b\u514b\u7684\u662fPD-L1\u7684\u57fa\u56e0\u514b\u9686\u548c\u86cb\u767d\u8868\u8fbe\uff0c\u6240\u4ee5\u5728Medarex\u7684\u5185\u90e8\u4ee3\u53f7\u91cc\uff0cPD-L1\u9879\u76ee\u7684\u4ee3\u53f7\u662fMDX-1105\uff0c\u53cd\u800c\u6392\u5728PD-1\u9879\u76eeMDX-1106\u524d\u9762\uff0cMDX-1107\u5219\u662fPD-L2\u9879\u76ee\u7684\u4ee3\u53f7\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u501f\u52a9Medarex\u5f53\u65f6\u5df2\u6709\u7684\u4eba\u6e90\u5316\u5c0f\u9f20\u6297\u4f53\u5e73\u53f0\uff0cMedarex\u7684\u7814\u7a76\u4eba\u5458\u7528PD-1\u3001PD-L1\u548cPD-L2\u86cb\u767d\u6ce8\u5c04\u5c0f\u9f20\uff0c\u5e76\u4ece\u5c0f\u9f20\u813e\u810f\u91cc\u5206\u79bb\u5230\u4e86\u80fd\u751f\u4ea7\u4e0a\u8ff0\u6297\u4f53\u7684B\u7ec6\u80de\uff0c\u518d\u901a\u8fc7\u878d\u5408B\u7ec6\u80de\u548c\u9aa8\u9ad3\u7624\u7ec6\u80de\uff0c\u5c31\u5f97\u5230\u4e86\u80fd\u957f\u671f\u7a33\u5b9a\u4ea7\u751f\u4e0a\u8ff0\u6297\u4f53\u7684\u6742\u4ea4\u7624\u7ec6\u80de\u682a\u3002\u8fd9\u9879\u5de5\u4f5c\u7531\u662f\u6742\u4ea4\u7624\u7ec4\u7684\u5434\u4eea\u548c\u9ec4\u6d77\u6625\u534f\u52a9\u5b8c\u6210\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u901a\u8fc7\u6d4b\u5e8f\u77e5\u9053\u7b5b\u9009\u5230\u7684PD-1\u6297\u4f53\u7684\u53ef\u53d8\u533a\u540e\uff0cMedarex\u56e2\u961f\u8bbe\u8ba1\u4e86\u65b0\u7684\u5e8f\u5217\uff0c\u5c06PD-1\u6297\u4f53\u7684\u53ef\u53d8\u533a\u4e0eIgG4\u6052\u5b9a\u533a\u7ed3\u5408\uff0c\u540c\u65f6\u5c06IgG4\u6052\u5b9a\u533a\u7684228\u4f4d\u70b9\u4e1d\u6c28\u9178\u66ff\u6362\u6210\u812f\u6c28\u9178\uff0c\u89e3\u51b3\u4e86\u5929\u7136IgG4\u6297\u4f53\u5728\u4f53\u5185\u7684\u4e0d\u7a33\u5b9a\u6027\u95ee\u9898\u3002\u8fd9\u6837\u5c31\u5f97\u5230\u4e86Nivolumab\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">MDX-1106\u5728\u6297\u4f53\u7b5b\u9009\u9636\u6bb5\u662f\u6bd4\u8f83\u987a\u5229\u7684\uff0c2001\u5e74\u521d\u7acb\u9879\uff0c\u540c\u5e74\u5e95\u5c31\u62ff\u5230\u4e86\u5148\u5bfc\u6297\u4f53\u3002\u968f\u540e\u7684\u4e34\u5e8a\u524d\u5f00\u53d1\u5de5\u4f5c\u82b1\u8d39\u4e86\u5927\u91cf\u7684\u65f6\u95f4\uff0c\u6bd4\u5982\u5efa\u7acb\u4f53\u5916\u6d3b\u6027\u68c0\u6d4b\u65b9\u6cd5\u3001\u5c0f\u9f20\u52a8\u7269\u6a21\u578b\u53ca\u98df\u87f9\u7334\u6bd2\u7406\u5b9e\u9a8c\u65b9\u6cd5\u7b49\u7b49\u3002PD-1\u5728\u5f53\u65f6\u4ecd\u5c5e\u5168\u65b0\u9886\u57df\uff0c\u57fa\u7840\u79d1\u7814\u7f3a\u4e4f\u79ef\u7d2f\uff0c\u56e2\u961f\u5fc5\u987b\u5728\u4e00\u7247\u7a7a\u767d\u4e2d\u8fdb\u884c\u5f00\u62d3\u6027\u7684\u7814\u7a76\uff0c\u5728\u5b9e\u8df5\u4e2d\u63a2\u7d22\u5168\u65b0\u7684\u5b9e\u9a8c\u65b9\u6cd5\u3002\u5176\u4e2d\u4e3b\u8981\u96be\u70b9\u5728\u4e8e\u627e\u5230\u4e00\u4e2a\u53ef\u9760\u7684\u9c81\u68d2\u6027\u4f53\u5916\u5b9e\u9a8c\u65b9\u6cd5\u4ee5\u8bc4\u4f30\u6297\u4f53\u7684\u529f\u80fd\u548c\u6d3b\u6027\uff0c\u7ecf\u8fc7\u4e00\u5e74\u591a\u7684\u52aa\u529b\uff0c\u7ec8\u4e8e\u5b8c\u6210\u4e86\u65b9\u6cd5\u7684\u5efa\u7acb\u3002\u968f\u540e\u7684\u52a8\u7269\u6a21\u578b\u5b9e\u9a8c\u4e5f\u591a\u6709\u6ce2\u6298\uff0c\u5f53\u65f6\u4e3b\u6d41\u7684\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u5bf9PD-1\u6297\u4f53\u57fa\u672c\u6ca1\u6709\u5e94\u7b54\uff0c\u76f4\u52302004\u5e74\u5e95\u624d\u5728MC38\u80bf\u7624\u6a21\u578b\u4e0a\u89c2\u5bdf\u5230\u4e86\u4e00\u5b9a\u7597\u6548\u3002\u5982\u4eca\u5168\u7403\u5404\u5730\u7684PD-1\/PD-L1\u6297\u4f53\u5f00\u53d1\u9879\u76ee\u591a\u4f1a\u4f7f\u7528MC38\u80bf\u7624\u6a21\u578b\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u51fa\u4e8e\u516c\u53f8\u77e5\u8bc6\u4ea7\u6743\u7b49\u65b9\u9762\u7684\u8003\u8651\uff0cMedarex\u5728\u5b8c\u6210Nivolumab\u7684\u7814\u53d1\u540e\uff0c\u53ea\u901a\u8fc7\u4e13\u5229\u7684\u5f62\u5f0f\u5bf9Nivolumab\u8fdb\u884c\u4e86\u4fdd\u62a4\uff0c\u672a\u7acb\u523b\u53d1\u8868\u6587\u7ae0\u3002\u76f4\u52302014\u5e74Nivolumab\u4e0a\u5e02\u524d\u5915\u624d\u53d1\u8868\u6587\u7ae0\uff0c\u8be6\u7ec6\u4ecb\u7ecd\u4e86Nivolumab\u7684\u7b5b\u9009\u548c\u9274\u5b9a\u8fc7\u7a0b\u53ca\u98df\u87f9\u7334\u6bd2\u7406\u5b9e\u9a8c\u6570\u636e\uff088\uff09\uff0c\u6b64\u6587\u7b2c\u4e00\u4f5c\u8005\u662f\u738b\u5e38\u7389\u3002\u6309\u7167\u6587\u4e2d\u63d0\u53ca\u7684\u56e2\u961f\u5206\u5de5\uff0c\u738b\u5e38\u7389\u8d1f\u8d23\u8fd9\u4e2a\u9879\u76ee\u7684\u6982\u5ff5\u8bbe\u8ba1\u3001\u8bd5\u9a8c\u65b9\u6cd5\u7684\u5f00\u53d1\u7b49\u7b49\u5de5\u4f5c\u4ee5\u53ca\u9879\u76ee\u7684\u76d1\u7763\uff0c\u662fNivolumab\u6beb\u65e0\u4e89\u8bae\u7684\u7b2c\u4e00\u53d1\u660e\u4eba\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">2003\u5e741\u6708\uff0c\u672c\u5eb6\u4f51\u548c\u5c0f\u91ce\u5236\u836f\u7684\u4e13\u5229\uff087\uff09\u516c\u5e03\u4e86\uff0cMedarex\u610f\u8bc6\u5230\u81ea\u5df1\u7684PD-1\u6297\u4f53\u53ef\u80fd\u7ed5\u4e0d\u5f00\u8fd9\u4e2a\u4e13\u5229\uff0c\u4f5c\u4e3a\u65e9\u671f\u7814\u53d1\u578b\u516c\u53f8\u4e5f\u9700\u8981\u5408\u4f5c\u4f19\u4f34\u5206\u644a\u9ad8\u6602\u7684\u4e34\u5e8a\u5f00\u53d1\u8d39\u7528\uff0c\u53cc\u65b9\u4e8e2005\u5e745\u670813\u65e5\u5ba3\u5e03\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff089\uff09\uff0c\u65b0\u95fb\u7a3f\u4e2d\u660e\u786e\u63d0\u5230\u4f7f\u7528\u5c0f\u91ce\u5236\u836f\u7684PD-1\u4e13\u5229\u548cMedarex\u7684\u6297\u4f53\u5f00\u53d1\u5e73\u53f0\u4ee5\u5171\u540c\u5f00\u53d1PD-1\u6297\u4f53\u3002\u6839\u636e\u53cc\u65b9\u7684\u534f\u8bae\uff0c\u5c0f\u91ce\u5236\u836f\u83b7\u5f97\u4e86PD-1\u6297\u4f53\u9664\u5317\u7f8e\u4ee5\u5916\u7684\u5168\u7403\u6743\u76ca\uff0c\u800cMedarex\u4fdd\u7559\u4e86PD-1\u6297\u4f53\u5728\u5317\u7f8e\u7684\u5546\u4e1a\u6743\u76ca\u3002\u6709\u7406\u7531\u76f8\u4fe1\uff0c\u672c\u5eb6\u4f51\u548c\u5c0f\u91ce\u5236\u836f\u5e76\u672a\u91cd\u89c6PD-1\u5355\u6297\u7684\u4e34\u5e8a\u4ef7\u503c\u30022011\u5e74\uff0c\u6536\u8d2d\u4e86Medarex\u7684\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\uff08BMS\uff09\uff0c\u6ca1\u82b1\u4ec0\u4e48\u4ee3\u4ef7\u5c31\u4ece\u5c0f\u91ce\u5236\u836f\u6362\u56de\u4e86PD-1\u6297\u4f53\u5728\u6b27\u6d32\u548c\u4e2d\u56fd\u7684\u5546\u4e1a\u6743\u76ca(10)\u3002Nivolumab\u5728\u4e2d\u56fd\u5f00\u59cb\u9500\u552e\u7684\u5934\u4e24\u5929\u7684\u9500\u552e\u989d\u91d1\u989d\u5df2\u8d85\u8fc71.5\u4ebf\u5143\u4eba\u6c11\u5e01\uff0c\u8fd9\u6050\u6015\u8fdc\u51fa\u4e4e\u7b7e\u7f72\u534f\u8bae\u53cc\u65b9\u7684\u610f\u6599\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">2004\u5e74\u524d\u540e\uff0cMedarex\u4e00\u65b9\u9762\u548c\u5c0f\u91ce\u5236\u836f\u5c55\u5f00\u8c08\u5224\uff0c\u4e00\u65b9\u9762\u4e5f\u5728\u6784\u5efa\u81ea\u5df1\u7684\u4e13\u5229\u4fdd\u62a4\u58c1\u5792\uff0c\u8d76\u5728\u53cc\u65b9\u8fbe\u6210\u534f\u8bae\u524d\u76842005\u5e745\u67089\u65e5\uff0c\u63d0\u4ea4\u4e86\u591a\u4efd\u548cPD-1\u76f8\u5173\u7684\u4e13\u5229\uff1aMethods for treating cancer using anti-pd-1 antibodies\uff0811\uff09\u3001Human Monoclonal Antibodies To Programmed Death 1(PD-1) And Methods For Treating Cancer Using Anti-PD-1 Antibodies Alone or in Combination with Other Immunotherapeutics\uff0812\uff09\u3001Methods for treating cancer using anti-PD-1 antibodies in combination with anti-CTLA-4 antibodies\uff0813\uff09\u7b49\u7b49\u3002\u5148\u524d\u6709\u4e0d\u5c11\u4e2d\u6587\u62a5\u9053\u4e2d\u8ba4\u4e3a\u5c0f\u91ce\u5236\u836f\u53c2\u4e0e\u4e86PD-1\u6297\u4f53\u7684\u5f00\u53d1\uff0c\u4e00\u4e2a\u7406\u7531\u5c31\u662f\u4e0a\u8ff0\u4e13\u5229\u4e2d\u6709\u5c0f\u91ce\u5236\u836f\u7684\u540d\u5b57\u3002\u4e8b\u5b9e\u4e0a\uff0c\u4e0a\u8ff0\u51e0\u4efd\u4e13\u5229\u7684\u7533\u8bf7\u673a\u6784\u548c\u53d1\u660e\u4eba\u5747\u6765\u81eaMedarex\uff0c\u4e0e\u5c0f\u91ce\u5236\u836f\u5b8c\u5168\u65e0\u5173\u3002\u6743\u5229\u4eba\u4e2d\u5305\u542b\u5c0f\u91ce\u5236\u836f\u7684\u539f\u56e0\u662f2014\u5e746\u6708\uff0cBMS\u548c\u5c0f\u91ce\u5236\u836f\u4e3a\u4e86\u51c6\u5907\u8d77\u8bc9\u9ed8\u6c99\u4e1c\uff0c\u53cc\u65b9\u4ea4\u53c9\u6301\u6709\u76f8\u4e92\u6388\u6743\u5bf9\u65b9\u4e00\u7cfb\u5217\u4e13\u5229\uff0c\u4ece\u800c\u5728\u8fd9\u4e9b\u4e13\u5229\u4e0a\u6dfb\u52a0\u4e86\u5c0f\u91ce\u5236\u836f\u3002\u5982\u679c\u8fd9\u4e9b\u4e2d\u6587\u62a5\u9053\u80fd\u770b\u770b\u4e13\u5229\u7684\u53d8\u8fc1\u8fc7\u7a0b\uff0c\u53ef\u80fd\u4f1a\u6709\u4e0d\u540c\u7684\u7ed3\u8bba\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">2014\u5e749\u67084\u65e5\uff0c\u5728\u9ed8\u6c99\u4e1c\u516c\u53f8\u7684PD-1\u5355\u6297Keytruda\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u7684\u5f53\u591c\uff0cBMS\u5411\u9ed8\u6c99\u4e1c\u516c\u53f8\u63d0\u8d77\u4e86\u8bc9\u8bbc,\u79f0\u9ed8\u6c99\u4e1c\u7684Keytruda\u4fb5\u72af\u4e86BMS\/\u5c0f\u91ce\u5236\u836f\u5173\u4e8ePD-1\u6297\u4f53\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u7684\u7cfb\u5217\u4e13\u5229\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">2017\u5e741\u670820\u65e5\uff0cBMS\/\u5c0f\u91ce\u5236\u836f\u516c\u53f8\u5ba3\u5e03\u548c\u9ed8\u6c99\u4e1c\u5c31PD-1\u5355\u6297\u7684\u4e13\u5229\u8bc9\u8bbc\u7b7e\u7f72\u4e86\u4e00\u9879\u548c\u89e3\u53ca\u5168\u7403\u4e13\u5229\u8bb8\u53ef\u534f\u8bae\uff0814\uff09\uff1a\u9ed8\u6c99\u4e1c\u8981\u5411BMS\/\u5c0f\u91ce\u5236\u836f\u652f\u4ed86.25\u4ebf\u7f8e\u5143\u7684\u9996\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u57282017\uff5e2023\u5e74\u95f4Keytruda\u9500\u552e\u989d\u76846.5%\uff0c2024\uff5e2026\u5e74\u95f4Keytruda\u9500\u552e\u989d\u76842.4%\uff0cBMS\u548c\u5c0f\u91ce\u5c06\u630975\/25\u7684\u6bd4\u4f8b\u5206\u6210\u3002\u7c97\u7565\u4f30\u7b97\u9ed8\u6c99\u4e1c\u603b\u5171\u5c06\u652f\u4ed8\u8d85\u8fc760\u4ebf\u7f8e\u5143\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 0.3em 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;height: 2em;background-color: rgb(249, 110, 87);color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u7b2c\u4e09\u90e8\u5206\uff1a\u8fdb\u5165\u4e34\u5e8a<\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;height: 2em;width: 0.5em;vertical-align: top;border-left: 0.5em solid rgb(249, 110, 87);word-wrap: break-word !important;border-top: 1em solid transparent !important;border-bottom: 1em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"padding: 3px 10px;max-width: 100%;box-sizing: border-box;display: inline-block;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;background-color: rgba(255, 255, 255, 0.498039);display: inline-block;color: rgb(13, 14, 13);text-align: justify;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">2006\u5e748\u6708\uff0cMedarex\u7684PD-1\u6297\u4f53MDX1106\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u8fdb\u5165\u4e34\u5e8aI\u671f\u8bd5\u9a8c\uff0c\u9996\u6279\u8ba1\u5212\u5165\u7ec439\u540d\u764c\u75c7\u590d\u53d1\u7684\u75c5\u4eba(15)\u3002\u9700\u8981\u6307\u51fa\u7684\u662f\uff0cMedarex\u7684PD-L1\u6297\u4f53MDX1105\u4e5f\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684PD-L1\u6297\u4f53\uff0c\u4e8e2008\u5e748\u6708\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u8fdb\u5165\u4e34\u5e8aI\u671f\uff0c\u9996\u6279\u8ba1\u5212\u5165\u7ec4286\u540d\u764c\u75c7\u590d\u53d1\u7684\u75c5\u4eba\uff0816\uff09\u3002MDX1105\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u540e\u6765\u53d1\u8868\u5728\u65b0\u82f1\u683c\u5170\u6742\u5fd7\u4e0a\uff0823\uff09\uff0c\u9057\u61be\u7684\u662fBMS\u4e3b\u52a8\u653e\u5f03\u4e86MDX1105\u7684\u540e\u7eed\u5f00\u53d1\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u4f5c\u4e3a\u4e00\u4e2a\u5168\u65b0\u7684\u80bf\u7624\u514d\u75ab\u836f\u7269\uff0cMDX1106\u65e9\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u51e0\u7ecf\u5468\u6298\uff0c\u7531\u4e8e\u5bf9\u80bf\u7624\u514d\u75ab\u836f\u7269\u7684\u4e0d\u4e86\u89e3\uff0c\u6700\u521d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ec8\u70b9\u9009\u62e9\u4e86\u4f20\u7edf\u9776\u5411\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ec8\u70b9\uff1a\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u5ba2\u89c2\u5e94\u7b54\u7387\uff08ORR\uff09\u3002\u80bf\u7624\u514d\u75ab\u836f\u7269\u5728\u8fd9\u4e24\u70b9\u4e0a\u5e76\u4e0d\u6bd4\u4f20\u7edf\u9776\u5411\u836f\u7269\u5177\u6709\u592a\u591a\u7684\u4f18\u52bf\u3002\u514d\u75ab\u836f\u7269\u7684\u771f\u6b63\u4f18\u52bf\uff1a\u836f\u6548\u6301\u7eed\u65f6\u95f4\u957f\uff0c\u5e94\u7b54\u7684\u764c\u75c7\u75c5\u4eba\u5b58\u6d3b\u671f\u957f\uff0c\u4e14\u6709\u5f88\u5927\u51e0\u7387\u5b9e\u73b0\u4e34\u5e8a\u6cbb\u6108\u7b49\u4f18\u52bf\uff0c\u8981\u5230\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u884c\u597d\u51e0\u5e74\u4ee5\u540e\u624d\u80fd\u88ab\u89c2\u5bdf\u5230\u3002Medarex\u7ba1\u7406\u5c42\u4e5f\u5bf9\u516c\u53f8\u7684\u672a\u6765\u6709\u4e86\u7591\u8651\uff0c2009\u5e74\uff0cBMS\u4ee528\u4ebf\u7f8e\u5143\u6536\u8d2d\u4e86Medarex\uff0cMedarex\u6700\u7ec8\u6ca1\u80fd\u72ec\u7acb\u8fd0\u8425\u5230PD-1\u836f\u7269\u5927\u653e\u5149\u5f69\uff0c\u6210\u4e3a\u65b0\u4e00\u4ee3\u5e7f\u8c31\u6027\u9769\u547d\u6027\u6297\u764c\u836f\u7269\u7684\u90a3\u4e00\u5929\uff0c\u8fd9\u662f\u8ba9\u4eba\u627c\u8155\u53f9\u606f\u7684\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u4e0a\u8ff0\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u4e8e2010\u5e74\u7b2c\u4e00\u6b21\u516c\u5e03\uff0817\uff09\uff0c\u53c2\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u7684\u75c5\u4eba\u4e2d\uff0c\u4e00\u4f4d\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u5b9e\u73b0\u4e86\u5b8c\u5168\u7f13\u89e3\uff0c\u4e00\u4f4d\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u548c\u4e00\u4f4d\u80be\u764c\u60a3\u8005\u5b9e\u73b0\u4e86\u90e8\u5206\u7f13\u89e3\u3002\u53e6\u6709\u4e24\u4f4d\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u80bf\u7624\u4e5f\u5f97\u5230\u4e86\u663e\u8457\u7f29\u5c0f\u3002\u968f\u540e2012\u5e74\u5728\u65b0\u82f1\u683c\u5170\u6742\u5fd7\u4e0a\u7684\u540e\u7eed\u7ed3\u679c\u66f4\u662f\u60ca\u8273\uff1a18%\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u300128%\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u548c27%\u7684\u80be\u764c\u60a3\u8005\u5f97\u5230\u4e86\u7f13\u89e3\uff0c\u8d77\u6548\u7684\u75c5\u4eba\u4e2d\u670966%\u7684\u7597\u6548\u6301\u7eed\u8d85\u8fc7\u4e00\u5e74\uff0818\uff09\u3002\u7ed3\u5408\u4e4b\u540eMedarex\u5728\u5404\u79cd\u533b\u5b66\u5e74\u4f1a\u7684\u62a5\u544a\uff0c\u8fd9\u4e00\u4e34\u5e8a\u7ed3\u679c\u5f15\u8d77\u4e86\u884c\u4e1a\u7684\u91cd\u89c6\uff0c\u5f15\u6765\u4e86\u540c\u4e1a\u7684\u89ca\u89ce\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u9ed8\u6c99\u4e1c\u516c\u53f8\u7ffb\u7bb1\u5012\u67dc\u53d1\u73b0\u81ea\u5df1\u4e5f\u6709\u4e00\u4e2a\u6254\u5728\u540e\u9662\u5783\u573e\u5806\u91cc\u7684PD-1\u6297\u4f53\uff0c\u6765\u81ea\u4e8e2009\u5e745\u6708\u5e76\u5165\u9ed8\u6c99\u4e1c\u7684\u5148\u7075\u8446\u96c5\u516c\u53f8\u3002\u800c\u5148\u7075\u8446\u96c5\u5219\u4ece2007\u5e74\u6536\u8d2d\u8377\u5170&nbsp;Organon\u65f6\u83b7\u5f97\uff0819\uff09\u3002\u636e\u798f\u5e03\u65af\u65e5\u540e\u7684\u91c7\u8bbf\uff0cOrganon\u7684PD-1\u6297\u4f53\u57282003\u5e74\u624d\u5f00\u59cb\u6784\u601d\uff0c\u8fdc\u843d\u540e\u4e8eMedarex\u7684MDX1106, 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style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">BMS\u540e\u6765\u5ba3\u79f0\uff1a\u4e3a\u4e86\u8ffd\u8d76\u8fdb\u5ea6\uff0c\u9ed8\u6c99\u4e1c\u4e0d\u60dc\u4eceBMS\u7684\u524d\u96c7\u5458Stephanie Schulman\u90a3\u91cc\u83b7\u5f97\u673a\u5bc6\u4fe1\u606f\uff0820\uff09\uff0cBMS\u4e3a\u6b64\u5bf9\u4e0a\u8ff0\u53cc\u65b9\u90fd\u63d0\u8d77\u8bc9\u8bbc\u3002\u5728\u5f97\u77e5BMS\u4e0d\u4f1a\u5728\u9ed1\u8272\u7d20\u7624\u9002\u5e94\u75c7\u4e0a\u5feb\u901f\u63a8\u8fdbPD-1\u6297\u4f53\uff0c\u4ee5\u907f\u514d\u548c\u81ea\u5bb6\u5df2\u6709\u7684CTLA-4\u6297\u4f53Yervoy\u5728\u9ed1\u8272\u7d20\u7624\u9002\u5e94\u75c7\u4e0a\u7684\u7ade\u4e89\u540e\u3002\u9ed8\u6c99\u4e1c\u516c\u53f8\u91c7\u7528\u4e86\u4e00\u4e2a\u6fc0\u8fdb\u7684\u4e34\u5e8a\u65b9\u6848\u8bbe\u8ba1\uff1a\u4ee3\u53f7Keynote001\u7684\u4e34\u5e8aI\u671f\u8bd5\u9a8c\u4e0d\u65ad\u6269\u5927\u5165\u7ec4\u4eba\u6570\uff0c\u4ece\u6700\u521d\u4e0d\u523010\u4eba\u53d8\u62101260\u4eba\u3002\u5e76\u7528\u4e34\u5e8aI\u671f\u8bd5\u9a8c\u7684\u7ed3\u679c\u5728\u7f8e\u56fd\u7533\u8bf7\u4e86\u4e0a\u5e02\u6279\u51c6\uff0cMK-3475\u4e8e2014\u5e749\u67084\u65e5\u83b7\u5f97\u6279\u51c6\uff0c\u53cd\u800c\u5728\u9ed1\u8272\u7d20\u7624\u9002\u5e94\u75c7\u4e0a\u8fdb\u5ea6\u4e0a\u8d85\u8fc7\u4e86BMS\uff0c\u4ee5Keytruda\u4e3a\u5546\u54c1\u540d\u6210\u4e3a\u7b2c\u4e00\u4e2a\u5728\u7f8e\u56fd\u4e0a\u5e02\u9500\u552e\u7684PD-1\u6297\u4f53\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u800cBMS\u7684PD-1\u6297\u4f53Nivolumab\uff0c\u4ee5\u5546\u54c1\u540dOpdivo\u7684\u540d\u5b57\u4e8e2014\u5e746\u6708\u5728\u65e5\u672c\u83b7\u5f97\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\uff0c\u6210\u4e3a\u5168\u7403\u7b2c\u4e00\u4e2a\u88ab\u6279\u51c6\u7684PD-1\u836f\u7269\uff0c\u968f\u540e\u4e8e2014\u5e7412\u6708\u5728\u7f8e\u56fd\u83b7\u5f97\u6279\u51c6\uff0c2015\u5e743\u6708\u4ee5\u521b\u7eaa\u5f55\u7684\u901f\u5ea6\u5728\u7533\u62a5\u540e\u56db\u5929\u5185\u5f97\u5230\u7f8e\u56fdFDA\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u94c2\u5316\u7597\u540e\u4f9d\u7136\u8fdb\u5c55\u7684\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 0.3em 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;height: 2em;background-color: rgb(249, 110, 87);color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u540e\u8bb0<\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;height: 2em;width: 0.5em;vertical-align: top;border-left: 0.5em solid rgb(249, 110, 87);word-wrap: break-word !important;border-top: 1em solid transparent !important;border-bottom: 1em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"padding: 3px 10px;max-width: 100%;box-sizing: border-box;display: inline-block;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;background-color: rgba(255, 255, 255, 0.498039);display: inline-block;color: rgb(13, 14, 13);text-align: justify;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u4ece\u672c\u5eb6\u4f511992\u5e74\u53d1\u73b0PD-1\u86cb\u767d\uff0c\u52302014\u5e74Nivolumab\u4e0a\u5e02\uff0c\u4e2d\u95f4\u7ecf\u5386\u4e8622\u5e74\uff0c\u5373\u4f7f\u4ece2000\u5e74\u660e\u786ePD-1\/PD-L1\u7684\u529f\u80fd\u7b97\u8d77\u4e5f\u7ecf\u5386\u4e8614\u5e74\uff0c\u836f\u7269\u7814\u53d1\u7684\u8270\u5de8\uff0c\u53ef\u89c1\u4e00\u6591\u3002\u6beb\u65e0\u7591\u95ee\uff0cPD-1\/PD-L1\u7684\u53d1\u73b0\u8981\u5f52\u529f\u7528\u4e8e\u672c\u5eb6\u4f51\u7b49\u4eba\uff0c\u672c\u5eb6\u4f51\u5f88\u53ef\u80fd\u4f1a\u56e0\u6b64\u83b7\u5f97\u8bfa\u8d1d\u5c14\u5956\uff0c\u4f46\u4eceNivolumab\u7684\u53d1\u73b0\u8fc7\u7a0b\u4e5f\u53ef\u770b\u51fa\uff0c\u4f5c\u4e3a\u57fa\u7840\u79d1\u5b66\u5bb6\uff0c\u4ed6\u4eec\u5bf9\u8fd9\u4e2a\u836f\u7269\u7684\u5f00\u53d1\u5e76\u65e0\u592a\u591a\u8d21\u732e\u3002\u672c\u5eb6\u4f51\u548cFreeman\u7b49\u4eba\u53ef\u80fd\u5728\u4e4b\u540e\u7684\u5f88\u591a\u5e74\u90fd\u4e00\u76f4\u6ca1\u610f\u8bc6\u5230PD-1\/PD-L1\u5bf9\u764c\u75c7\u6cbb\u7597\u7684\u4f5c\u7528\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u53e6\u4e00\u4e2a\u4f8b\u5b50\u662fCTLA-4\u86cb\u767d\uff0c\u4e4b\u524d\u4e00\u76f4\u8ba4\u4e3a\uff0c\u6d3b\u5316\u540e\u7684T\u7ec6\u80de\u8868\u9762\u9ad8\u8868\u8fbeCTLA-4\u86cb\u767d\uff0c\u5f53\u6297\u539f\u9012\u5448\u7ec6\u80de\u8868\u9762\u7684B7\u5bb6\u65cf\u86cb\u767d\uff08B7-1\uff0cB7-2\uff09\u7ed3\u5408CTLA-4\u540e\uff0c\u5c31\u8d77\u5230\u6291\u5236T\u7ec6\u80de\u6d3b\u5316\u7684\u4f5c\u7528\u3002\u4e8e\u662f\u4eba\u4eec\u63a8\u6d4b\uff0cCTLA-4\u5355\u6297\u901a\u8fc7\u963b\u65adCTLA-4\u4e0eB7\u5bb6\u65cf\u86cb\u767d\u7ed3\u5408\u800c\u8d1f\u8c03\u63a7\u5bf9T\u7ec6\u80de\u7684\u6291\u5236\u3002\u4ece\u800c\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\u30022018\u5e745\u6708\u9a6c\u91cc\u5170\u5927\u5b66\u7684\u5218\u9633\u548c\u90d1\u76fc\u6307\u51fa\uff0c\u8fd9\u4e2a\u5047\u8bf4\u53ef\u80fd\u662f\u9519\u7684\uff0821\u300122\uff09\u3002\u5728\u8fd9\u4e24\u7bc7\u6587\u7ae0\u4e2d\uff0c\u4ed6\u4eec\u6307\u51fa\uff0cCTLA-4\u6297\u4f53\u662f\u901a\u8fc7\u6e05\u9664\u80bf\u7624\u5c40\u90e8\u7684\u8c03\u8282\u6027T\u7ec6\u80de\uff0c\u800c\u4e0d\u662f\u963b\u65adCTLA-4\/B7\u4fe1\u53f7\u901a\u8def\u6765\u5b9e\u73b0\u6cbb\u7597\u764c\u75c7\u7684\u7597\u6548\u3002\u8fd9\u5e76\u4e0d\u5f71\u54cdCTLA-4\u5355\u6297\u6210\u4e3a\u4e00\u4e2a\u5e74\u9500\u552e\u8fc710\u4ebf\u7f8e\u5143\u7684\u91cd\u78c5\u70b8\u5f39\u836f\u7269\u3002\u6709\u7406\u7531\u63e3\u6d4b\uff0c\u4e0d\u8fdc\u7684\u5c06\u6765\u53ef\u80fd\u4f1a\u6709\u4eba\u53d1\u73b0\uff0cPD-1\u6297\u4f53\u7684\u6297\u764c\u7597\u6548\u5e76\u4e0d\u5b8c\u5168\u662f\u56e0\u4e3a\u963b\u65adPD-1\/PD-L1\u901a\u8def\uff0c\u800c\u662f\u53e6\u6709\u95e8\u5f84\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u4e2d\u56fd\u7684\u5236\u836f\u884c\u4e1a\u6b63\u5728\u8bd5\u56fe\u8f6c\u578b\u8fdb\u519b\u521b\u65b0\u836f\u5f00\u53d1\uff0c\u5728\u4e3a\u9648\u5217\u5e73\u3001\u738b\u5e38\u7389\u7b49\u534e\u4eba\u5728\u80bf\u7624\u514d\u75ab\u9886\u57df\u505a\u51fa\u7684\u6210\u529f\u81ea\u8c6a\u7684\u540c\u65f6\uff0c\u8fd9\u4e00\u9886\u57df\u66f2\u6298\u7684\u51e0\u5341\u5e74\u91cc\u53ef\u80fd\u4e5f\u6709\u4e00\u4e9b\u7ecf\u9a8c\u548c\u6559\u8bad\u5bf9\u4e2d\u56fd\u7684\u521b\u65b0\u836f\u884c\u4e1a\u6709\u7528\u3002\u521b\u65b0\u836f\u79bb\u4e0d\u5f00\u57fa\u7840\u79d1\u7814\u7684\u79ef\u7d2f\uff0c\u521b\u65b0\u836f\u7684\u5f00\u53d1\u8fc7\u7a0b\u548c\u57fa\u7840\u79d1\u7814\u7684\u5173\u7cfb\u66f4\u50cf\u662f\u679c\u6811\u4e0e\u571f\u5730\u7684\u5173\u7cfb\u3002\u6ca1\u6709\u6df1\u539a\u7684\u57fa\u7840\u79d1\u7814\u7684\u79ef\u7d2f\uff0c\u5f88\u96be\u4ea7\u751f\u521b\u65b0\u836f\u3002\u7f8e\u56fd\u81f3\u4eca\u4ecd\u662f\u57fa\u7840\u79d1\u7814\u5b9e\u529b\u6700\u96c4\u539a\u7684\u56fd\u5bb6\uff0c\u7edd\u5927\u591a\u6570\u7684\u521b\u65b0\u836f\u4e5f\u8bde\u751f\u5728\u7f8e\u56fd\uff0c\u8fd9\u5c31\u597d\u50cf\u8d2b\u7620\u571f\u5730\u4e0a\u7684\u679c\u6811\uff0c\u96be\u4ee5\u957f\u51fa\u4e30\u7855\u7684\u679c\u5b9e\u3002\u4f46\u662f\u6ca1\u6709\u679c\u6811\u7684\u571f\u5730\u91cc\u4e5f\u6ca1\u6cd5\u51ed\u7a7a\u957f\u51fa\u6c34\u679c\u6765\uff0c\u6700\u591a\u957f\u51e0\u9897\u5c71\u836f\u86cb\u3002\u6ca1\u6709\u672c\u5eb6\u4f51\u7b49\u4eba\u53d1\u73b0PD-1\u7684\u529f\u80fd\uff0cOpdivo\u7684\u8bde\u751f\u65e0\u4ece\u8c08\u8d77\u3002\u6ca1\u6709Medarex\u56e2\u961f\u72ec\u5177\u6167\u773c\u7814\u53d1PD-1\u6297\u4f53\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\uff0c\u672c\u5eb6\u4f51\u8fd9\u4e00\u6210\u679c\u662f\u5426\u4f1a\u6df9\u6ca1\u5728\u6545\u7eb8\u5806\u91cc\u6211\u4eec\u4eca\u5929\u5df2\u4e0d\u5f97\u800c\u77e5\uff0c\u4eceOrganon\u81ea\u5df1\u7684PD-1\u6297\u4f53\u9879\u76ee\u6765\u770b\uff0c\u6050\u6015\u662f\u51f6\u591a\u5409\u5c11\u3002\u57fa\u7840\u79d1\u5b66\u5bb6\u548c\u65b0\u836f\u5f00\u53d1\u516c\u53f8\u7684\u5b9a\u4f4d\u4e0d\u540c\uff0c\u8bc4\u4f30\u65b0\u836f\u7684\u4e34\u5e8a\u610f\u4e49\u548c\u5546\u4e1a\u610f\u4e49\uff0c\u4e0d\u662f\u57fa\u7840\u79d1\u5b66\u5bb6\u7684\u804c\u8d23\uff0c\u4e5f\u4e0d\u5e94\u8be5\u53bb\u671f\u5f85\u57fa\u7840\u79d1\u5b66\u5bb6\u80fd\u5b8c\u6210\u521b\u65b0\u836f\u7684\u7814\u5236\u548c\u5f00\u53d1\u3002Medarex\u56e2\u961f\u7b5b\u9009\u5230\u6297\u4f53\u4ec5\u4ec5\u7528\u4e861\u5e74\u591a\uff0c\u4f46\u662f\u5efa\u7acb\u8bc4\u4ef7\u6297\u4f53\u529f\u80fd\u7684\u65b9\u6cd5\u4f53\u7cfb\u53c8\u82b1\u4e862\u5e74\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u66f4\u662f\u82b1\u4e868\u5e74\u3002\u9ed8\u6c99\u4e1c\u516c\u53f8\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e0a\u7684\u5927\u80c6\u8bbe\u8ba1\uff0c\u8ba9\u539f\u672c\u8fdb\u5ea6\u843d\u540e4\u5e74\u7684\u9879\u76ee\u80fd\u548cBMS\u6700\u540e\u540c\u65f6\u51b2\u7ebf\u3002\u4e00\u4e2a\u836f\u7269\u4ece\u5b9e\u9a8c\u5ba4\u8d70\u5411\u5e02\u573a\uff0c\u540e\u7eed\u5f00\u53d1\u7684\u91cd\u8981\u6027\u4e0d\u6bd4\u524d\u671f\u7b5b\u9009\u4f4e\u3002\u4eceMedarex\u548c\u5c0f\u91ce\u5236\u836f\u7684\u8c08\u5224\u7ed3\u679c\u4e0d\u96be\u770b\u51fa\uff0cMedarex\u4e00\u5f00\u59cb\u5c31\u610f\u8bc6\u5230PD-1\u6297\u4f53\u7684\u91cd\u8981\u6027\uff0c\u548c\u5c0f\u91ce\u5236\u836f\u7684\u5408\u4f5c\u624b\u6cd5\u591a\u5c11\u6709\u70b9\u5408\u7eb5\u8fde\u6a2a\u7684\u5473\u9053\uff0c\u800c\u5c0f\u91ce\u5236\u836f\u5219\u591a\u5c11\u6709\u70b9\u88ab\u8499\u5728\u9f13\u91cc\u3002\u968f\u7740\u56fd\u5185\u521b\u65b0\u836f\u7684\u53d1\u5c55\uff0c\u521b\u65b0\u836f\u516c\u53f8\u5fc5\u7136\u4f1a\u5f00\u5c55\u4e00\u7cfb\u5217\u7684\u5916\u90e8\u5408\u4f5c\uff0c\u5982\u4f55\u5f00\u5c55\u5546\u52a1\u62d3\u5c55\uff0c\u76f8\u4fe1\u5bf9\u56fd\u5185\u5927\u591a\u6570\u521b\u65b0\u836f\u516c\u53f8\u90fd\u662f\u4e00\u4e2a\u6311\u6218\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<p style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;min-height: 1em;line-height: normal;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section style=\"padding: 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 677px;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);background-color: rgba(235, 213, 176, 0.862745);border-radius: 0.7em;box-shadow: rgb(0, 0, 0) 0px 0px 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\u53c2\u8003\u6587\u732e\uff1a<\/em><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">Ishida, Y., Y. Agata, K. Shibahara, and T. Honjo. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.EMBO J. 1992 11:3887\u20133895<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">Shinohara, T., Taniwaki, M., Ishida, Y., Kawaichi, M., &amp;Honjo, T. (1994). Structure and Chromosomal Localization of the Human PD-1 Gene (PDCD1). Genomics, 1994 23(3), 704\u2013706.<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">Nishimura H, Nose M, Hiai H, Minato N, Honjo T. Development of lupuslike autoimmune diseases by disruption of the PD-1 gene encoding anITIM motif-carrying immunoreceptor. Immunity 1999;11:141\u201351.<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H,et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7family member leads to negative regulation of lymphocyte activation.J Exp Med 2000;192:1027\u201334.<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">Dong H, Zhu G, Tamada K, Chen L.B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.Nat Med. 1999 Dec;5(12):1365-1369.<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">DongH, Strome S, Salomao D, Tamura H, Hirano F, Flies D. et al. 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Res 2014. 2: 846\u2013856<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">https:\/\/www.fdanews.com\/articles\/72247-ono-and-medarex-enter-into-collaborative-research-agreement<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">https:\/\/news.bms.com\/press-release\/partnering-news\/bristol-myers-squibb-and-ono-enter-strategic-agreement-anti-pd-1-antib<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">Methods for treating cancer using anti-pd-1 antibodies<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">Human Monoclonal Antibodies To Programmed Death 1(PD-1) And Methods For Treating Cancer Using Anti-PD-1 Antibodies Alone or in Combination with Other Immunotherapeutics<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">Methods for treating cancer using anti-PD-1 antibodies in combination with anti-CTLA-4 antibodies<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">https:\/\/news.bms.com\/press-release\/partnering-news\/bristol-myers-squibb-and-ono-pharmaceutical-company-enter-settlement-a<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00441337<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00729664<\/em><\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">JR, Drake. 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N Engl J Med. 2012 Jun 28;366(26):2455-65.<\/em><\/span><\/p>\n<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(171, 25, 66);background-color: rgb(255, 215, 213);box-sizing: border-box !important;word-wrap: break-word !important;\">\u836f\u878d\u5708\u4e3a\u836f\u7269\u7b80\u8baf\u5408\u4f5c\u5e73\u53f0.<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u6587\u4f5c\u8005\u5f20\u7ee7\uff0c\u4ec5\u6388\u6743\u7f8e\u4e2d\u836f\u6e90\u548c\u836f\u7269\u7b80\u8baf\u8f6c\u8f7d\uff0c\u5176\u4ed6\u5a92\u4f53\u4e0d\u4e88\u8f6c\u8f7d\uff0c\u5426\u5219\u8ffd\u7a76\u76f8\u5173\u8d23\u4efb\u3002 \u672c\u6587\u7531\u7f8e\u4e2d\u836f\u6e90\u7f16\u8f91\u3002 \u968f\u7740P [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":38373,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38372"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=38372"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38372\/revisions"}],"predecessor-version":[{"id":38375,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38372\/revisions\/38375"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/38373"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=38372"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=38372"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=38372"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}