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alt=\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c32\u671f\uff09\" title=\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c32\u671f\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;text-align: justify;\"><span style=\"font-size: 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0.544px;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 18px;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><span class=\"\" style=\"max-width: 100%;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/section>\n<section style=\"max-width: 100%;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;background-color: rgb(255, 255, 255);background-image: linear-gradient(to right, rgb(76, 217, 100), rgb(90, 200, 250), rgb(0, 122, 255), rgb(52, 170, 220), rgb(88, 86, 214), rgb(255, 45, 85));box-sizing: border-box !important;word-wrap: break-word !important;height: 5px !important;\"><\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;text-align: justify;\"><span style=\"font-size: 15px;\">1\u3001\u534e\u6d77\u836f\u4e1a\u5411FDA\u7533\u62a5\u7684\u76d0\u9178\u4e8c\u7532\u53cc\u80cd\u7f13\u91ca\u7247\u7684\u65b0\u836f\u7b80\u7565\u7533\u8bf7\uff08ANDA\uff09\u5df2\u83b7\u5f97\u6279\u51c6\u3002\u76d0\u9178\u4e8c\u7532\u53cc\u80cd\u7f13\u91ca\u7247\u7531\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7814\u53d1\uff0c\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff0c\u4e8e2000\u5e74\u5728\u7f8e\u56fd\u4e0a\u5e02\u3002<\/span><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;text-indent: 0em;\"><span style=\"font-size: 15px;\"><strong><img loading=\"lazy\" align=\"\" class=\"\"   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alt=\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c32\u671f\uff09\" title=\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c32\u671f\uff09\"  \/><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;text-align: justify;\"><span style=\"font-size: 15px;text-indent: 0em;\">7\u3001\u6052\u745e\u533b\u836f\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u5173\u4e8e\u76d0\u9178\u5766\u7d22\u7f57\u8f9b\u7f13\u91ca\u80f6\u56ca\uff080.2mg\uff09\u7684\u300a\u836f\u54c1\u8865\u5145\u7533\u8bf7\u6279\u4ef6\u300b\uff0c\u8be5\u836f\u54c1\u901a\u8fc7\u4eff\u5236\u836f\u8d28\u91cf\u548c\u7597\u6548\u4e00\u81f4\u6027\u8bc4\u4ef7\u3002\u76d0\u9178\u5766\u7d22\u7f57\u8f9b\u7f13\u91ca\u80f6\u56ca\u4e3a\u826f\u6027\u524d\u5217\u817a\u80a5\u5927\u7528\u836f\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;text-align: justify;\"><span style=\"font-size: 15px;\">8\u3001\u4fe1\u8fbe\u751f\u7269\u5f00\u53d1\u7684\u91cd\u7ec4\u5168\u4eba\u6e90\u6297CD47\u5355\u514b\u9686\u6297\u4f53\uff08IBI188\uff09\uff0c\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u9881\u53d1\u7684\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u5375\u5de2\u764c\u5728\u5185\u7684\u591a\u79cd\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u80bf\u7624\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;text-align: justify;\"><span style=\"font-size: 15px;\">9\u3001\u590d\u661f\u533b\u836f\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5173\u4e8e\u540c\u610f\u91cd\u7ec4\u6297PD-1\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u8054\u5408\u91cd\u7ec4\u6297VEGF\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u7528\u4e8e\u665a\u671f\u5b9e\u4f53\u7624\u6cbb\u7597\u65b9\u6848\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6279\u51c6\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;text-align: justify;\"><span style=\"font-size: 15px;\">10\u3001\u56db\u73af\u533b\u836f\u5f00\u53d1\u7684\u80f0\u5c9b\u7d20\u7c7b\u4f3c\u7269\u95e8\u51ac\u80f0\u5c9b\u7d20\u6ce8\u5c04\u6db2\u3001\u95e8\u51ac\u80f0\u5c9b\u7d2030\u6ce8\u5c04\u6db2\u53ca\u95e8\u51ac\u80f0\u5c9b\u7d2050\u6ce8\u5c04\u6db2\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u9881\u53d1\u7684\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u3002\u95e8\u51ac\u80f0\u5c9b\u7d20\u4e3a\u4e00\u79cd\u901f\u6548\u80f0\u5c9b\u7d20\u7c7b\u4f3c\u7269\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\u3002<\/span><\/p>\n<section style=\"padding: 10px 10px 6px;max-width: 100%;color: rgb(51, 51, 51);font-size: 17px;letter-spacing: 0.544px;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u673a\u5236\/\u9776\u70b9\u7814\u7a76\u8fdb\u5c55<\/span><span class=\"\" style=\"max-width: 100%;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/section>\n<section style=\"max-width: 100%;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;background-color: rgb(255, 255, 255);background-image: linear-gradient(to right, rgb(76, 217, 100), rgb(90, 200, 250), rgb(0, 122, 255), rgb(52, 170, 220), rgb(88, 86, 214), rgb(255, 45, 85));box-sizing: border-box !important;word-wrap: break-word !important;height: 5px !important;\"><\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;text-align: justify;\"><span style=\"font-size: 15px;\">1\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u803f\u7f8e\u7389\u8bfe\u9898\u7ec4\u3001\u4e01\u5065\u8bfe\u9898\u7ec4\u548c\u8c2d\u654f\u4f73\u8bfe\u9898\u7ec4\u8054\u5408\u653b\u5173\u7684\u9488\u5bf9\u80bf\u7624\u8868\u89c2\u9057\u4f20\u5f02\u5e38\u7684\u7cbe\u51c6\u6cbb\u7597\u7b56\u7565\u7814\u7a76\u6210\u679c\u53d1\u8868\u5728\u751f\u7269\u5b66\u6743\u5a01\u6742\u5fd7\u300a\u7ec6\u80de\u300b\uff08Cell\uff09\u4e0a\u3002\u8be5\u7814\u7a76\u9488\u5bf9\u76ee\u524d\u80bf\u7624\u8868\u89c2\u9057\u4f20\u6297\u80bf\u7624\u836f\u7269\u7684\u4e34\u5e8a\u7528\u836f\u56f0\u5883\uff0c\u63ed\u793a\u4e86\u51b3\u5b9a\u7ec4\u86cb\u767d\u7532\u57fa\u8f6c\u79fb\u9176EZH2\u6291\u5236\u5242\u5b9e\u4f53\u7624\u7597\u6548\u54cd\u5e94\u7684\u6838\u5fc3\u673a\u5236\uff0c\u63d0\u51fa\u4e86\u65b0\u7684\u80bf\u7624\u5206\u7fa4\u7b56\u7565\u548c\u8054\u5408\u7528\u836f\u65b9\u6848\uff0c\u4e3a\u5e7f\u5927EZH2\u9ad8\u8868\u8fbe\u80bf\u7624\u7684\u4e2a\u6027\u5316\u6cbb\u7597\u6307\u660e\u4e86\u65b9\u5411\u3002<\/span><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;text-indent: 0em;\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537165435.jpeg\" alt=\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c32\u671f\uff09\" title=\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c32\u671f\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;text-align: justify;\"><span style=\"font-size: 15px;\">2\u3001\u4e2d\u79d1\u9662\u751f\u7269\u7269\u7406\u6240\u3001\u6e56\u5357\u5e08\u8303\u5927\u5b66\u7b49\u5904\u7684\u7814\u7a76\u4eba\u5458\u5728\u300aNature Communications\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cStructure of the Herpesvirus simplex virus type2 C-capsid with capsid-vertex-specific-component\u201d\u7684\u6587\u7ae0\u3002\u8fd9\u9879\u7814\u7a76\u5de5\u4f5c\u4e3a\u6838\u8863\u58f3\u4e0e\u5468\u56f4\u7684\u4e2d\u95f4\u4f53\u86cb\u767d\uff08tegument protein\uff09\u7684\u76f8\u4e92\u4f5c\u7528\u6a21\u5f0f\u63d0\u4f9b\u4e86\u575a\u5b9e\u57fa\u7840\u548c\u7cbe\u7ec6\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u8fdb\u4e00\u6b65\u9610\u660e\u4e86\u75b1\u75b9\u75c5\u6bd2\u751f\u6d3b\u53f2\u4e2d\u5b8c\u6574\u75c5\u6bd2\u7ec4\u88c5\u7684\u65f6\u7a7a\u590d\u6742\u6027\uff0c\u4e3a\u672a\u6765\u6297\u75c5\u6bd2\u6cbb\u7597\u65b9\u6848\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u601d\u8def\u548c\u65b9\u5411\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;text-align: justify;\"><span style=\"font-size: 15px;\">3\u3001\u6e05\u534e\u5927\u5b66\u751f\u547d\u5b66\u9662\u6768\u96ea\u745e\u7814\u7a76\u7ec4\u5728\u300aThe EMBO Journal\u300b\u53d1\u8868\u6587\u7ae0\uff0c\u9996\u6b21\u62a5\u9053\u8c03\u63a7RNA\u526a\u63a5\u7684\u5173\u952e\u86cb\u767dHNRNPC\u662f\u6291\u5236\u4e73\u817a\u764c\u7ec6\u80de\u5e72\u6270\u7d20\u4fe1\u53f7\u901a\u8def\u5e76\u7ef4\u6301\u80bf\u7624\u7ec6\u80de\u5feb\u901f\u589e\u6b96\u7684\u6838\u5fc3\u86cb\u767d\u3002\u8fd9\u9879\u7814\u7a76\u5de5\u4f5c\u9996\u6b21\u5c06RNA\u5f02\u5e38\u526a\u63a5\u4e0e\u53cc\u94feRNA\u6fc0\u6d3b\u7684\u5e72\u6270\u7d20\u4fe1\u53f7\u901a\u8def\u8054\u7cfb\u5728\u4e00\u8d77\uff0c\u63d0\u51fa\u4e86\u5185\u6e90RNA\u8c03\u63a7\u80bf\u7624\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\u6d3b\u6027\u7684\u65b0\u673a\u5236\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;text-indent: 0em;\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001 1\u3001\u7f8e\u56fdFDA\u6279\u51c6\u963f\u65af\u5229\u5eb7\u7684Lumoxiti\uff08moxetumomab pasudotox-t 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