{"id":38729,"date":"2018-09-10T01:00:00","date_gmt":"2018-09-17T06:24:11","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e6%a2%b3%e7%90%86%ef%bc%9a%e5%85%a8%e7%90%83%e6%96%b0%e5%85%ac%e5%bc%80%e5%b0%8f%e5%88%86%e5%ad%90%e5%8c%96%e5%90%88%e7%89%a9%e4%b8%93%e5%88%a9%e7%94%b3%e8%af%b7%ef%bc%882018-07-1508-14%ef%bc%89\/"},"modified":"2018-09-17T14:24:15","modified_gmt":"2018-09-17T06:24:15","slug":"%e6%a2%b3%e7%90%86%ef%bc%9a%e5%85%a8%e7%90%83%e6%96%b0%e5%85%ac%e5%bc%80%e5%b0%8f%e5%88%86%e5%ad%90%e5%8c%96%e5%90%88%e7%89%a9%e4%b8%93%e5%88%a9%e7%94%b3%e8%af%b7%ef%bc%882018-07-1508-14%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/38729\/","title":{"rendered":"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\u636eClarivate Analytics Cortellis\u6570\u636e\u5e93\uff08\u68c0\u7d22\u65e5\u671f\uff1a2018\u5e748\u670820\u65e5\uff09\uff0c2018\u5e747\u670815\u65e5\u81f38\u670814\u65e5\u671f\u95f4\uff0c\u5168\u7403\u9996\u6b21\u516c\u5f00\u7684\u4e13\u5229\u5171\u8ba116584\u4ef6\uff0c\u6d89\u53ca\u836f\u7269\u76f8\u5173\u7684\u4e13\u5229\u7c7b\u578b\u5305\u62ec\u5236\u5242\u3001\u8bca\u65ad\u5206\u6790\u6d4b\u5b9a\u3001\u65b0\u7528\u9014\u3001\u5c0f\u5206\u5b50\u5316\u5408\u7269\u3001\u836f\u7269\u8054\u7528\u3001\u751f\u7269\u5236\u54c1\u7b49\uff0c\u5176\u4e2d\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u6709149\u4ef6\uff0c\u672c\u6587\u7740\u91cd\u5bf9\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u8fdb\u884c\u5206\u6790\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\u672c\u9636\u6bb5\u5168\u7403\u9996\u6b21\u516c\u5f00\u7684\u5c0f\u5206\u5b50\u836f\u7269\u65b0\u4ea7\u54c1\u4e13\u5229\u6d89\u53ca\u7684\u6cbb\u7597\u9886\u57df\u6709\u80bf\u7624\u3001\u708e\u75c7\u53ca\u611f\u67d3\u6027\u75be\u75c5\u3001\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u4ee3\u8c22\u6027\u75be\u75c5\u7b49\u3002\u6309\u5177\u4f53\u75be\u75c5\u6765\u5206\uff0c\u80ba\u764c\u3001\u80f0\u817a\u764c\u3001\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u3001\u4e73\u817a\u764c\u3001\u7ed3\u80a0\u764c\u4f4d\u5217\u524d\u4e94\uff0c\u4e13\u5229\u4ef6\u6570\u8d85\u8fc710\u4ef6\u7684\u9002\u5e94\u75c7\u5982\u56fe1\u6240\u793a\uff08\u6709\u4e9b\u4e13\u5229\u6d89\u53ca\u4e0d\u6b62\u4e00\u79cd\u9002\u5e94\u75c7\uff1b\u53e6\u5916\uff0c\u80bf\u7624\u9886\u57df\u7684\u4e13\u5229\u7533\u8bf7\u591a\u672a\u8a00\u660e\u7528\u4e8e\u4f55\u79cd\u80bf\u7624\uff0c\u5f52\u7eb3\u65f6\u672a\u5217\u5165\u5177\u4f53\u75be\u75c5\u4e2d\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537165452.jpeg\" alt=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\" title=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\"  \/><\/p>\n<section class=\"_editor\">\n<section style=\"margin-top: 8px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"height: 1px;background-color: #0aa857;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"margin-top: -1px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;padding-right: 10px;padding-left: 10px;border-width: 1px;border-radius: 0px;border-style: none solid solid;border-color: #0aa857;background-color: #ffffff;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"letter-spacing: 2px;font-size: 18px;\"><span style=\"color:#2fc37f;\"><strong>\u5168\u7403\u77e5\u540d\u836f\u4f01\u4e13\u5229\u516c\u5e03\u5206\u6790<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;line-height: 2;text-align: justify;text-indent: 2em;\"><span style=\"font-size: 16px;\">\u5728\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\uff0c\u845b\u5170\u7d20\u53f2\u514b\u3001Araxes Pharma LLC\u516c\u53f8\u5206\u522b\u67096\u4ef6\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u88ab\u516c\u5e03\uff0c\u5176\u6b21\u4e3a\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u67095\u4ef6\u4e13\u5229\u88ab\u516c\u5e03\uff0cGenfit SA\u3001\u5f3a\u751f\u5206\u522b\u67094\u4ef6\u4e13\u5229\u88ab\u516c\u5e03\uff0c\u5176\u5b83\u5236\u836f\u5de8\u5934\u5982\u8f89\u745e\uff083\u4ef6\uff09\u3001\u963f\u65af\u6cf0\u62c9\u65af\u5236\u836f\uff083\u4ef6\uff09\u3001UCB SA\uff083\u4ef6\uff09\u548cLEO Pharma A\/S\uff083\u4ef6\uff09\u4e5f\u6709\u4e13\u5229\u88ab\u516c\u5e03\u3002\u4ee5\u4e0b\u5bf9\u845b\u5170\u7d20\u53f2\u514b\u3001Araxes Pharma LLC\u548c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u5e03\u7684\u4e13\u5229\u8fdb\u884c\u7b80\u8ff0\uff0c\u800c\u5176\u5b83\u90e8\u5206\u77e5\u540d\u836f\u4f01\u516c\u5f00\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff083\u4ef6\u4ee5\u4e0a\uff09\u72b6\u51b5\u5982\u88684\u6240\u793a\u3002<\/span><\/p>\n<section style=\"display: inline-block;margin-right: -10px;width: 3rem;vertical-align: middle;\"><img  style=\"width: auto;\"  class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537165452.jpeg\" alt=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\" title=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\"  \/><\/section>\n<section style=\"display: inline-block;vertical-align: middle;border-bottom: 1px solid #31b38c;box-sizing: border-box;\">\n<p style=\"letter-spacing: 2px;text-align: justify;margin-right: 15px;margin-left: 15px;min-width: 1px;\"><span style=\"color:#45c39d;font-size:16px;\"><strong>\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8<\/strong><\/span><\/p>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\u5728\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\uff0c\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\u65b0\u516c\u5f006\u4ef6\u5c0f\u5206\u5b50\u5316\u5408\u7269\u65b0\u4ea7\u54c1\u4e13\u5229\u7533\u8bf7\uff08\u88681\uff09\u3002\u5176\u4e2d\uff0cWO 2018137618\u3001WO 2018137607\u3001WO 2018137619\u3001WO 2018137593\u3001WO 2018137573\u5747\u4e3a\u6d89\u53ca\u65b0\u578b\u5432\u5511\u884d\u751f\u7269\u53ca\u5176\u76d0\u6216\u5305\u542b\u5176\u7684\u7ec4\u5408\u7269\uff0c\u5728\u6cbb\u7597<\/span><span style=\"font-size: 16px;color: rgb(61, 167, 66);\"><strong>\u5e15\u91d1\u68ee\u75c5\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u548c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\uff08ALS\uff09\u4ee5\u53ca\u5728LRRK-2\u6fc0\u9176\u4e2d\u5177\u6709G2019S\u7a81\u53d8\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u7684\u5e94\u7528<\/strong><\/span><span style=\"font-size: 16px;\">\u3002\u4e13\u5229WO 2018137618\u3001WO 2018137607\u3001WO 2018137593\u6d89\u53ca\u65b0\u578b1-\u5627\u5576-4- yl -1H-\u5432\u5511\u884d\u751f\u7269\uff0c\u8fd9\u4e9b\u4e13\u5229\u4e2d\u6d89\u53ca\u7684\u5316\u5408\u7269\u5747\u4e3aLRRK-2\u6291\u5236\u5242\u3002\u4e13\u5229WO 2018137618\u6240\u516c\u5f00\u7684\u5316\u5408\u7269\u5728\u4f53\u5916\u91cd\u7ec4\u7ec6\u80de\u7684LRRK-2 AlphaScreen\u68c0\u6d4b\u4e2d\uff0c\u5982\u4f7f\u7528SH-SY5Y\u7ec6\u80de\uff08\u7b2c89\u81f391\u9875\uff09\uff0c\u4e00\u4e9b\u5316\u5408\u7269pIC50\u503c\uff1e6\uff1b\u4e13\u5229WO 2018137607\u63d0\u5230\u516b\u79cd\u5316\u5408\u7269\u5305\u62ec1-\uff083-\u6c1f-4-\uff081-\uff086-\uff082-\uff08\u7f9f\u7532\u57fa\uff09\u5417\u5549\uff09-2-\u7532\u57fa\u5627\u5576-4-\u57fa\uff09-5-\u7532\u57fa-1H-\u5432\u5511-6-\u57fa\uff09-\u54cc\u5576-1-\u57fa]\u4e19\u70f7-2-\u9187\uff08I\uff09\uff08\u6743\u5229\u8981\u6c429\uff0c\u7b2c131\u9875\uff1b\u5728\u5b9e\u4f8b32\u4e2d\u516c\u5f00\u7684\u672a\u77e5\u5f02\u6784\u4f53\uff08I\uff09\uff0c\u7b2c109\u9875\uff09\u3002\u6b64\u5916\uff0c\u8fd8\u63d0\u51fa\u4e86\u4e00\u79cdMarkush\u7ed3\u6784\uff08\u6743\u5229\u8981\u6c421\uff0c\u7b2c128\u9875\uff09\u3002\u5728\u4f53\u5916\u91cd\u7ec4\u7ec6\u80de\u7684LRRK-2 AlphaScreen\u68c0\u6d4b\u4e2d\uff0c\u672a\u77e5\u7684\u5f02\u6784\u4f53\uff08I\uff09\u4f7f\u7528SH-SY5Y\u7ec6\u80de\u663e\u793apIC50\u503c\u4e3a8\uff08\u7b2c121\u9875\u548c\u7b2c124\u9875\uff09\u3002\u6b64\u5916\uff0c\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\u8fd8\u516c\u5f00\u4e86\u4e00\u4e2a\u4e13\u5229GB 201810290\uff0c\u663e\u793a\u4fdd\u62a4\u67d0\u65b0\u578b\u5316\u5408\u7269\uff0c\u65e0\u66f4\u591a\u76f8\u5173\u4fe1\u606f\uff0c\u8be5\u4e13\u5229\u4e8e2018\u5e748\u67088\u65e5\u9996\u6b21\u516c\u5f00\uff0c\u5c1a\u672a\u6388\u6743\u3002<\/span><\/p>\n<p style=\"text-align: justify;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><img loading=\"lazy\" class=\"\"     height=\"605\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 586px;height: 514px;\" width=\"663\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537165452.jpeg\" alt=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\" title=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\"  \/><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;margin-right: -10px;width: 3rem;vertical-align: middle;\"><img  style=\"width: auto;\"  class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537165452-1.jpeg\" alt=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\" title=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\"  \/><\/section>\n<section style=\"display: inline-block;vertical-align: middle;border-bottom: 1px solid #31b38c;box-sizing: border-box;\">\n<p style=\"letter-spacing: 2px;text-align: justify;margin-right: 15px;margin-left: 15px;min-width: 1px;\"><span style=\"color:#45c39d;font-size:16px;\"><strong>Araxes Pharma LLC\u516c\u53f8<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\u5728\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\uff0cAraxes Pharma LLC\u516c\u53f8\u65b0\u516c\u5e036\u4ef6\u5c0f\u5206\u5b50\u5316\u5408\u7269\u65b0\u4ea7\u54c1\u4e13\u5229\u7533\u8bf7\uff08\u88682\uff09\u3002\u8fd9\u4e9b\u4e13\u5229\u5747\u6d89\u53ca\u65b0\u7684\u7a20\u5408\u6742\u73af\u5316\u5408\u7269\u53ca\u5176\u76d0\uff0c\u540c\u4f4d\u7d20\u5f62\u5f0f\u3001\u7acb\u4f53\u5f02\u6784\u4f53\u548c\/\u6216\u524d\u836f\uff0c\u4ee5\u53ca\u5b83\u4eec\u7684\u7ec4\u5408\u7269\uff0c<\/span><strong><span style=\"font-size: 16px;color: rgb(61, 167, 66);\">\u7528\u4e8e\u7531KRAS G12C\u3001HRAS G12C\u6216NRAS G12C\u7a81\u53d8\u4ecb\u5bfc\u7684<\/span><\/strong><span style=\"font-size: 16px;\">\u764c\u75c7\u5305\u62ec\u8840\u6db2\u80bf\u7624\u3001\u80f0\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u548c\u80ba\u764c\u7684\u6cbb\u7597\u3002\u540c\u65f6\uff0c\u8fd8\u63d0\u51fa\u4e86\uff08a\uff09\u6291\u5236\u7ec6\u80de\u7fa4\u4f53\u589e\u6b96\u548c\u80bf\u7624\u8f6c\u79fb\u7684\u65b9\u6cd5\uff1b\uff08b\uff09\u901a\u8fc7\u5c06\u7a81\u53d8\u4f53\u4e0e\u5316\u5408\u7269\u53cd\u5e94\u5236\u5907\u6807\u8bb0\u7684KRAS\u3001HRAS\u6216NRAS G12C\u7a81\u53d8\u86cb\u767d\uff1b\uff08c\uff09\u8c03\u8282KRAS\u3001HRAS\u6216NRAS GL 2C\u7a81\u53d8\u86cb\u767d\u7684\u6d3b\u6027\u3002\u6240\u8ff0\u5316\u5408\u7269\u7528\u4f5cKRAS\u3001HRAS\u6216NRAS G12C\u7a81\u53d8\u4f53\u7684\u6291\u5236\u5242\u3002<\/span><br  \/><\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><img loading=\"lazy\" class=\"\"     height=\"640\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 592px;height: 640px;\" width=\"666\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537165453.jpeg\" alt=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\" title=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\"  \/><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;margin-right: -10px;width: 3rem;vertical-align: middle;\"><img  style=\"width: auto;\"  class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537165453.jpeg\" alt=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\" title=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\"  \/><\/section>\n<section style=\"display: inline-block;vertical-align: middle;border-bottom: 1px solid #31b38c;box-sizing: border-box;\">\n<p style=\"letter-spacing: 2px;text-align: justify;margin-right: 15px;margin-left: 15px;min-width: 1px;\"><span style=\"color:#45c39d;font-size:16px;\"><strong>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\u5728\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u65b0\u516c\u5e035\u4ef6\u4e13\u5229\u7533\u8bf7\uff08\u88683\uff09\u3002\u8fd9\u4e9b\u4e13\u5229\u6d89\u53ca\u73af\u4e19\u70f7\u7fa7\u9178\u884d\u751f\u7269\u30012-\u5421\u55ea-2-\u73af\u4e19\u70f7\u7fa7\u9178\u884d\u751f\u7269\u30012-[5-\uff08\u5432\u54da-1-\u6c28\u57fa\uff09\u5421\u55ea-2-\u57fa]\u73af\u4e19\u70f7\u7fa7\u9178\u884d\u751f\u7269\u53ca\u8fd9\u7c7b\u5316\u5408\u7269\u5176\u76d0\u548c\u7ec4\u5408\u7269\uff0c\u4f5c\u4e3a<\/span><strong><span style=\"font-size: 16px;color: rgb(61, 167, 66);\">GPR40\u8c03\u8282\u5242<\/span><\/strong><span style=\"font-size: 16px;\">\u7528\u4e8e\u4ee3\u8c22\u6027\u75be\u75c5\u7684\u6cbb\u7597\uff0c\u5305\u62ec2\u578b\u7cd6\u5c3f\u75c5\u3001\u80f0\u5c9b\u7d20\u62b5\u6297\u3001\u80a5\u80d6\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u8840\u8102\u5f02\u5e38\u7b49\u3002<\/span><br  \/><\/p>\n<p style=\"text-align: justify;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);\"><img loading=\"lazy\" class=\"\"     height=\"539\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 609px;height: 479px;\" width=\"664\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537165453.jpeg\" alt=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\" title=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\"  \/><\/p>\n<p style=\"text-align: justify;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537165454.jpeg\" alt=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\" title=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\"  \/><\/p>\n<p style=\"text-align: justify;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537165454.jpeg\" alt=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\" title=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\"  \/><\/p>\n<p style=\"text-align: justify;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537165454.jpeg\" alt=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\" title=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\"  \/><\/p>\n<section class=\"_editor\">\n<section style=\"margin-top: 8px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"height: 1px;background-color: #0aa857;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"margin-top: -1px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;padding-right: 10px;padding-left: 10px;border-width: 1px;border-radius: 0px;border-style: none solid solid;border-color: #0aa857;background-color: #ffffff;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"letter-spacing: 2px;font-size: 18px;\"><span style=\"color:#2fc37f;\"><strong>\u6211\u56fd\u5236\u836f\u516c\u53f8\u53ca\u7814\u7a76\u673a\u6784<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;text-indent: 2em;\">\u5728\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\uff0c\u6211\u56fd\u5236\u836f\u516c\u53f8\u53ca\u7814\u7a76\u673a\u6784\u516c\u5f00\u7684\u4e13\u5229\u7533\u8bf7\u7ea618\u4ef6\uff0c\u8be6\u89c1\u88685\u3002\u5177\u4f53\u6765\u770b\uff1a<\/span><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\uff081\uff09\u519b\u4e8b\u533b\u5b66\u79d1\u5b66\u9662\u4e13\u5229WO 2018130207\u9996\u6b21\u516c\u5f00\u4e864,4-\u4e8c\u82ef\u57fa\u54cc\u5576\u7c7b\u5316\u5408\u7269\u6216\u5176\u53ef\u836f\u7528\u76d0\u3001\u836f\u7269\u7ec4\u5408\u7269\u53ca\u7528\u9014\u3002\u8be5\u53d1\u660e\u7684\u5316\u5408\u7269\u6216\u5176\u53ef\u836f\u7528\u76d0\u3001\u836f\u7528\u7ec4\u5408\u7269\u5177\u6709\u660e\u663e\u7684N\u578b\u9499\u79bb\u5b50\u901a\u9053\u963b\u65ad\u6d3b\u6027\uff0c\u5e76\u5177\u6709\u826f\u597d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\uff0c\u80fd\u6709\u6548\u5730\u7f13\u89e3\u75bc\u75db\uff0c\u5177\u6709\u4f5c\u4e3a\u65b0\u7684\u9884\u9632\u6216\u6cbb\u7597\u75bc\u75db\u3001\u4e2d\u98ce\u3001\u8111\u7f3a\u8840\u3001\u9152\u7cbe\u6210\u763e\u3001\u9152\u7cbe\u4e2d\u6bd2\u3001\u80be\u75c5\u3001\u7531\u9547\u75db\u836f\u7269\u5f15\u8d77\u7684\u6210\u763e\u6027\u75c5\u75c7\u6216\u7531\u9547\u75db\u836f\u7269\u5f15\u8d77\u7684\u8010\u53d7\u6027\u75c5\u75c7\u7684\u836f\u7269\u7684\u6f5c\u529b\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\uff082\uff09\u6069\u745e\u751f\u7269\u533b\u836f\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\u4e13\u5229WO 2018137639\u516c\u5f00\u4e86\u4e00\u79cd\u7ec4\u86cb\u767d\u7532\u57fa\u8f6c\u79fb\u9176EZH2\u6291\u5236\u5242\u3001\u5176\u5236\u5907\u65b9\u6cd5\u53ca\u5176\u4f5c\u4e3a\u7ec4\u86cb\u767d\u7532\u57fa\u8f6c\u79fb\u9176EZH2\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u4e0e\u7ec4\u86cb\u767d\u7532\u57fa\u8f6c\u79fb\u9176EZH2\u76f8\u5173\u7684\u75be\u75c5\u7279\u522b\u662f\u764c\u75c7\u7684\u7528\u9014\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\uff083\uff09\u6210\u90fd\u5965\u749f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u4e13\u5229WO 2018133661\u516c\u5f00\u4e86\u4e00\u79cd\u65b0\u7684\u787c\u9178\u884d\u751f\u7269\u53ca\u5176\u836f\u7269\u7ec4\u5408\u7269\u3002\u540c\u65f6\uff0c\u8fd8\u63d0\u4f9b\u4e86\u8be5\u787c\u9178\u884d\u751f\u7269\u5728\u5236\u5907\u6297\u80bf\u7624\u836f\u7269\u6216\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u7c7b\u836f\u7269\u4e2d\u7684\u7528\u9014\uff0c\u5177\u4f53\u7684\uff0c\u8be5\u53d1\u660e\u63d0\u4f9b\u4e86\u8be5\u787c\u9178\u884d\u751f\u7269\u5728\u5236\u5907\u86cb\u767d\u9176\u4f53\u80f0\u51dd\u4e73\u86cb\u767d\u9176\u6837\u86cb\u767d\u9176\u6291\u5236\u5242\u7c7b\u836f\u7269\u4e2d\u7684\u7528\u9014\uff0c\u4ee5\u53ca\u5728\u9884\u9632\u548c\/\u6216\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u7ed3\u80a0\u764c\u7b49\u764c\u75c7\u836f\u7269\u4e2d\u7684\u7528\u9014\uff1b\u4e3a\u4e34\u5e8a\u4e0a\u7b5b\u9009\u548c\/\u6216\u5236\u5907\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u7c7b\u836f\u7269\u4ee5\u53ca\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u7ed3\u80a0\u764c\u7b49\u764c\u75c7\u836f\u7269\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u9009\u62e9\uff0c\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\uff084\uff09WO 2018133870\u4e3a\u6b63\u5927\u5929\u6674\u836f\u4e1a\u96c6\u56e2\u80a1\u4efd\u6709\u9650\u516c\u53f8\u548c\u5357\u4eac\u660e\u5fb7\u65b0\u836f\u7814\u53d1\u80a1\u4efd\u6709\u9650\u516c\u53f8\u5171\u540c\u7533\u8bf7\u7684\u4e13\u5229\uff0c\u6d89\u53ca\u4e00\u79cd\u5982\u901a\u5f0f\u6240\u793a\u5316\u5408\u7269\uff08\u88685\uff09\u53ca\u5176\u836f\u5b66\u4e0a\u53ef\u63a5\u53d7\u7684\u76d0\u6216\u5176\u4e92\u53d8\u5f02\u6784\u4f53\uff0c\u4ee5\u53ca\u8be5\u5316\u5408\u7269\u4f5c\u4e3aCaspase\u6291\u5236\u5242\u7684\u5e94\u7528\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\uff085\uff09\u798f\u5efa\u5e7f\u751f\u5802\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u548c\u5357\u4eac\u660e\u5fb7\u65b0\u836f\u7814\u53d1\u80a1\u4efd\u6709\u9650\u516c\u53f8\u5728\u8be5\u65f6\u95f4\u6bb5\u5171\u516c\u5e03\u4e862\u4ef6\u4e13\u5229\uff0c\u5747\u6d89\u53caASK1\u6291\u5236\u5242\u53ca\u5176\u5236\u5907\u65b9\u6cd5\u548c\u5e94\u7528\u3002\u5176\u4e2d\uff0cWO 2018133866\u6d89\u53ca\u4f5c\u4e3aASK1\u6291\u5236\u5242\u7684\u5421\u5576\u884d\u751f\u7269\u5176\u4e92\u53d8\u5f02\u6784\u4f53\u6216\u5176\u836f\u5b66\u4e0a\u53ef\u63a5\u53d7\u7684\u76d0\uff1b\u5728\u4f53\u5185PK\u7814\u7a76\u4e2d\uff0c\u8bd5\u9a8c\u5316\u5408\u7269\uff0859396 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2018137610\u516c\u5f00\u4e86\u4e00\u79cd\u53d6\u4ee3\u76841-(\u5f02\u6076\u5511-3-\u57fa)-3-(3-\u6c1f-4-\u82ef\u57fa)\u8132\u884d\u751f\u7269\u53ca\u5176\u5236\u5907\u65b9\u6cd5\u548c\u7528\u9014\uff0c\u5c5e\u4e8e\u6709\u673a\u5408\u6210\u836f\u7269\u6280\u672f\u9886\u57df\u3002\u5305\u62ec\u63d0\u4f9b\u4e86\u4e00\u79cd\u53d6\u4ee3\u76841-(\u5f02\u6076\u5511-3-\u57fa)-3-(3-\u6c1f-4-\u82ef\u57fa)\u8132\u884d\u751f\u7269\uff08\u88685\uff09\uff0c\u8fd8\u63d0\u4f9b\u4e86\u4e0a\u8ff0\u53d6\u4ee3\u76841-(\u5f02\u6076\u5511-3-\u57fa)-3-(3-\u6c1f-4-\u82ef\u57fa)\u8132\u884d\u751f\u7269\u7684\u5236\u5907\u65b9\u6cd5\uff0c\u53ca\u5176\u5728\u5236\u5907FMS-\u6837\u916a\u6c28\u9178\u6fc0\u91763\u6291\u5236\u5242\u7684\u7528\u9014\u3002\u4e3a\u672c\u9886\u57df\u4e2d\u7684\u6fc0\u9176\u6291\u5236\u5242\u7684\u5236\u5907\u3001\u6297\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u836f\u7269\u7684\u5236\u5907\u3001\u65b0\u751f\u8840\u7ba1\u751f\u6210\u6291\u5236\u5242\u548c\u6297\u80bf\u7624\u836f\u7269\u7684\u5236\u5907\u63d0\u4f9b\u4e86\u65b0\u7684\u6709\u6548\u9009\u62e9\uff0c\u5177\u6709\u5f88\u597d\u7684\u5e94\u7528\u524d\u666f\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\uff0814\uff09\u6d59\u6c5f\u5927\u5b66\u4e13\u5229WO 2018137555\u516c\u5f00\u4e86\u4e00\u79cd\u591a\u6c1f\u53d6\u4ee3\u82b3\u8054\u6742\u73af\u7c7b\u884d\u751f\u7269\uff0c\u5177\u6709\u901a\u5f0fI\u6216\u901a\u5f0fI&#8217;\u6240\u793a\u7684\u7ed3\u6784\uff08\u88685\uff09\uff0c\u5176\u4e2dR1\u3001R2\u4e2d\u81f3\u5c11\u6709\u4e00\u4e2a\u6c1f\u539f\u5b50\uff1bRc\u3001Rd\u3001Re\u3001Rf\u4e2d\u81f3\u5c11\u4e24\u4e2a\u53d6\u4ee3\u57fa\u4e3a\u6c1f\u539f\u5b50\uff1b\u4ee5\u53ca\u5176\u5149\u5b66\u5f02\u6784\u4f53\uff1b\u6216\u5176\u836f\u5b66\u4e0a\u53ef\u63a5\u53d7\u7684\u76d0\u6216\u6eb6\u5242\u5408\u7269\uff1b\u6216\u5176\u5149\u5b66\u5f02\u6784\u4f53\u836f\u5b66\u4e0a\u53ef\u63a5\u53d7\u7684\u76d0\u6216\u6eb6\u5242\u5408\u7269\u3002\u542b\u6709\u4e0a\u8ff0\u591a\u6c1f\u53d6\u4ee3\u82b3\u8054\u6742\u73af\u7c7b\u884d\u751f\u7269\u7684\u7ec4\u5408\u7269\u4ee5\u53ca\u5176\u5728\u5236\u5907\u6297\u80bf\u7624\u836f\u7269\u4e2d\u7684\u5e94\u7528\u3002\u6240\u8ff0\u5316\u5408\u7269\u5bf9Akt1\u6709\u663e\u8457\u7684\u6291\u5236\u4f5c\u7528\uff0c\u5bf9\u4eba\u5375\u5de2\u764c\u7ec6\u80de\u682a\u3001\u7ed3\u80a0\u764c\u7ec6\u80de\u682a\u3001\u524d\u5217\u8132\u764c\u7ec6\u80de\u682a\u7b49\u80bf\u7624\u7ec6\u80de\u682a\u663e\u793a\u51fa\u5f3a\u6548\u7684\u589e\u6b96\u6291\u5236\u6d3b\u6027\u3002\u56e0\u6b64\uff0c\u6240\u8ff0\u5316\u5408\u7269\u53ef\u4f5c\u4e3aAkt\u6291\u5236\u5242\u5e94\u7528\u4e8e\u6cbb\u7597\u4eba\u6216\u52a8\u7269\u7ec6\u80de\u589e\u6b96\u6027\u76f8\u5173\u7684\u5b9e\u4f53\u7624\u6216\u8840\u764c\u7684\u836f\u7269\u4e2d\u3002<\/span><\/p>\n<p style=\"text-align: justify;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);\"><img loading=\"lazy\" class=\"\"     height=\"672\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 602px;height: 672px;\" width=\"624\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537165455.jpeg\" alt=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\" title=\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.07.15~08.14\uff09\"  \/><\/p>\n<p style=\"text-align: justify;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);\">\n<section class=\"_editor\">\n<section style=\"margin-top: 8px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"height: 1px;background-color: #0aa857;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"margin-top: -1px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;padding-right: 10px;padding-left: 10px;border-width: 1px;border-radius: 0px;border-style: none solid solid;border-color: #0aa857;background-color: #ffffff;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"letter-spacing: 2px;font-size: 18px;\"><span style=\"color:#2fc37f;\"><strong>\u5c0f\u7ed3<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\u4ece\u516c\u5f00\u7684\u4e13\u5229\u7533\u8bf7\u6587\u4ef6\u6765\u770b\uff0c\u5168\u7403\u77e5\u540d\u836f\u4f01\u836f\u7269\u7814\u53d1\u9886\u57df\u5e03\u5c40\u591a\u6837\uff0c\u4e0e\u5404\u516c\u53f8\u4ea7\u54c1\u7ebf\u89c4\u5212\u4e00\u81f4\uff0c\u5982\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\u65b0\u516c\u5f00\u7684\u4e13\u5229\u5747\u4e3a\u65b0\u578b\u5432\u5511\u884d\u751f\u7269\u53ca\u5176\u76d0\u6216\u5305\u542b\u5176\u7684\u7ec4\u5408\u7269\uff0c\u4e3b\u8981\u5e94\u7528\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u9886\u57df\uff1bAraxes Pharma LLC\u516c\u53f8\u65b0\u516c\u5e036\u4ef6\u5c0f\u5206\u5b50\u5316\u5408\u7269\u65b0\u4ea7\u54c1\u4e13\u5229\u7533\u8bf7\u5747\u6d89\u53ca\u65b0\u7684\u7a20\u5408\u6742\u73af\u5316\u5408\u7269\u53ca\u5176\u76d0\uff0c\u540c\u4f4d\u7d20\u5f62\u5f0f\u3001\u7acb\u4f53\u5f02\u6784\u4f53\u548c\/\u6216\u524d\u836f\uff0c\u4ee5\u53ca\u5b83\u4eec\u7684\u7ec4\u5408\u7269\uff0c\u4e3b\u8981\u7528\u4e8e\u7279\u5b9a\u7a81\u53d8\u7684\u80bf\u7624\u7684\u6cbb\u7597\uff1b\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u65b0\u516c\u5e03\u4e13\u5229\u7684\u91cd\u70b9\u5728\u4e8e\u53ef\u4f5c\u4e3aGPR40\u8c03\u8282\u5242\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u7528\u4e8e\u4ee3\u8c22\u6027\u75be\u75c5\u7684\u6cbb\u7597\u3002\u4ece\u6211\u56fd\u836f\u4f01\u53ca\u79d1\u7814\u673a\u6784\u516c\u5f00\u7684\u836f\u7269\u5c0f\u5206\u5b50\u4e13\u5229\u7533\u8bf7\u6765\u770b\uff0c\u75be\u75c5\u9886\u57df\u591a\u96c6\u4e2d\u5728\u6297\u80bf\u7624\u9886\u57df\uff0c\u4ece\u7533\u8bf7\u673a\u6784\u6765\u770b\uff0c\u5357\u4eac\u660e\u5fb7\u65b0\u836f\u7814\u53d1\u80a1\u4efd\u6709\u9650\u516c\u53f8\u8054\u5408\u6b63\u5927\u5929\u6674\u836f\u4e1a\u96c6\u56e2\u80a1\u4efd\u6709\u9650\u516c\u53f8\u3001\u798f\u5efa\u5e7f\u751f\u5802\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u516c\u5f00\u4e86\u591a\u4ef6\u4e13\u5229\uff1b\u6c5f\u82cf\u8c6a\u68ee\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u3001\u6c5f\u82cf\u6052\u745e\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u3001\u6df1\u5733\u5e02\u5854\u5409\u745e\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\u5747\u67092\u4ef6\u4e13\u5229\u516c\u5f00\u3002\u5c0f\u5206\u5b50\u836f\u7269\u7684\u5f00\u53d1\u59cb\u7ec8\u662f\u521b\u65b0\u836f\u7269\u7814\u7a76\u7684\u91cd\u70b9\uff0c\u671f\u5f85\u8fd9\u4e9b\u4e13\u5229\u4ea7\u54c1\u80fd\u591f\u5728\u540e\u671f\u5f00\u53d1\u4e2d\u5f97\u4ee5\u987a\u5229\u63a8\u8fdb\u3002<\/span><br  \/><\/p>\n<section class=\"_editor\">\n<section style=\"margin-top: 8px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"height: 1px;background-color: #0aa857;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"margin-top: -1px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;padding-right: 10px;padding-left: 10px;border-width: 1px;border-radius: 0px;border-style: none solid solid;border-color: #0aa857;background-color: #ffffff;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"letter-spacing: 2px;font-size: 18px;\"><span style=\"color:#2fc37f;\"><strong>\u53c2\u8003\u8d44\u6599<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">1. Clarivate Analytics Cortellis\u6570\u636e\u5e93,\u68c0\u7d22\u65e5\u671f: 2018\u5e7408\u670820\u65e5.<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">2.\u4e07\u8c61\u4e91\u6570\u636e\u5e93,\u68c0\u7d22\u65e5\u671f: 2018\u5e7408\u670820\u65e5.<\/span><\/p>\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u636eClarivate Analytics Cortellis\u6570\u636e\u5e93\uff08\u68c0\u7d22\u65e5\u671f\uff1a2018\u5e748\u670820\u65e5\uff09\uff0c2018 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":38730,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38729"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=38729"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38729\/revisions"}],"predecessor-version":[{"id":38742,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38729\/revisions\/38742"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/38730"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=38729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=38729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=38729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}