{"id":38762,"date":"2018-08-31T01:00:00","date_gmt":"2018-09-17T06:24:29","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af%ef%bc%882018%e5%b9%b4%e7%ac%ac30%e6%9c%9f%ef%bc%89\/"},"modified":"2018-09-17T14:24:31","modified_gmt":"2018-09-17T06:24:31","slug":"%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af%ef%bc%882018%e5%b9%b4%e7%ac%ac30%e6%9c%9f%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/38762\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c30\u671f\uff09"},"content":{"rendered":"
\n
\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/span><\/section>\n
<\/section>\n

1\u3001\u62dc\u8033\uff08Bayer\uff09\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u7684Jivi\uff08BAY94-9027\uff09\u83b7\u5f97FDA\u6279\u51c6\uff0c\u7528\u4e8e\u5e38\u89c4\u9884\u9632\u6027\u6cbb\u7597\u63a5\u53d7\u8fc7\u524d\u671f\u6cbb\u7597\u768412\u5c81\u4ee5\u4e0aA\u578b\u8840\u53cb\u75c5\u60a3\u8005\u3002<\/span>
<\/p>\n

2\u3001\u4e13\u6ce8\u65b0\u578b\u6297\u751f\u7d20\u5f00\u53d1\u4ee5\u89e3\u51b3\u591a\u91cd\u8010\u836f\u95ee\u9898\u7684\u751f\u7269\u5236\u836f\u516c\u53f8Tetraphase Pharmaceuticals\u5ba3\u5e03\u79f0\uff0c\u7f8e\u56fdFDA\u5df2\u6279\u51c6\u65d7\u4e0bXERAVA\u2122\uff08eravacycline\uff09\u7528\u4e8e\u6cbb\u7597\u590d\u6742\u7684\u8179\u8154\u5185\u611f\u67d3\uff08cIAI\uff09\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c30\u671f\uff09\"<\/p>\n

3\u3001\u827e\u4f2f\u7ef4\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u4e86IMBRUVICA\u00ae\uff08\u4f9d\u9c81\u66ff\u5c3c\uff0cIbrutinib\uff09\u8054\u5408\u5229\u59a5\u6614\u5355\u6297\uff08RITUXAN\u00ae\uff09\u6cbb\u7597\u6210\u4eba\u7279\u53d1\u6027\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u7f55\u89c1\u4e14\u65e0\u6cd5\u6cbb\u6108\u7684\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u3002<\/span>
<\/p>\n

4\u3001\u6765\u81ea\u8bfa\u534e\u548c\u5409\u5229\u5fb7\u7684\u4e24\u6b3eCAR-T\u7ec6\u80de\u7597\u6cd5Kymriah\uff08tisagenlecleucel\uff0cCTL019\uff09\u548cYescarta\uff08axicabtagene ciloleucel\uff09\u8fd1\u65e5\u5728\u6b27\u76df\u76d1\u7ba1\u65b9\u9762\u540c\u65f6\u4f20\u6765\u4e86\u559c\u8baf\u3002\u8bfa\u534e\u65b9\u9762\uff0cKymriah\u5df2\u83b7\u6279\u7528\u4e8e\u4e24\u79cdB\u7ec6\u80de\u6076\u6027\u80bf\u7624\uff1a1\u3001\u75c5\u60c5\u96be\u6cbb\u6216\u79fb\u690d\u540e\u590d\u53d1\u6216\u51fa\u73b02\u6b21\u53ca\u4ee5\u4e0a\u590d\u53d1\u768425\u5c81\u53ca\u4ee5\u4e0bB\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08B-ALL\uff09\u513f\u7ae5\u548c\u5e74\u8f7b\u6210\u4eba\u60a3\u8005\uff1b2\u3001\u65e2\u5f80\u63a5\u53d72\u79cd\u6216\u591a\u79cd\u7cfb\u7edf\u7597\u6cd5\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08r\/r DLBCL\uff09\u6210\u4eba\u60a3\u8005\u3002\u5409\u5229\u5fb7\u65b9\u9762\uff0cYescarta\u4e5f\u5df2\u83b7\u6279\u7528\u4e8e\u4e24\u79cd\u4fb5\u88ad\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\uff1a\u65e2\u5f80\u5df2\u63a5\u53d72\u79cd\u62162\u79cd\u4ee5\u4e0a\u7cfb\u7edf\u7597\u6cd5\u7684\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027DLBCL\u548c\u539f\u53d1\u7eb5\u9694B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08PMBCL\uff09\u6210\u4eba\u60a3\u8005\u3002<\/span><\/p>\n

5\u3001\u8fd1\u65e5\uff0cOrtho\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6Altreno\uff08tretinoin\uff0c\u7ef4\u7532\u9178\uff0c0.05%\uff09\u4e73\u6db2\u7528\u4e8e9\u5c81\u53ca\u4ee5\u4e0a\u60a3\u8005\u5bfb\u5e38\u75e4\u75ae\u7684\u5c40\u90e8\u6cbb\u7597\u3002<\/span><\/p>\n

6\u3001Shire\u516c\u53f8\u65e5\u524d\u5ba3\u5e03\uff0c\u5176\u9488\u5bf9\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\uff08HAE\uff09 \u7684\u65b0\u836fTakhzyro\uff08lanadelumab-flyo\uff09\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\u3002\u8be5\u836f\u53ef\u9884\u9632\u7f55\u89c1\u75c5HAE\uff0c\u9002\u7528\u4e8e12\u5c81\u53ca\u4ee5\u4e0a\u60a3\u8005\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c30\u671f\uff09\"<\/p>\n

7\u3001\u65e5\u524d\uff0c\u6b27\u76df\u59d4\u5458\u4f1a\u5df2\u7ecf\u6279\u51c6\u62dc\u8033\u6297\u51dd\u836f\u7269\u62dc\u745e\u59a5\uff08\u5229\u4f10\u6c99\u73ed\uff09\u7684\u65b0\u9002\u5e94\u75c7\uff1a\u5229\u4f10\u6c99\u73ed2.5 mg\u4e00\u5929\u4e24\u6b21\u8054\u5408\u963f\u53f8\u5339\u679775-100mg\u4e00\u5929\u4e00\u6b21\u7528\u4e8e\u9ad8\u7f3a\u8840\u98ce\u9669\u7684\u51a0\u72b6\u52a8\u8109\u75be\u75c5\u6216\u8005\u75c7\u72b6\u6027\u5916\u5468\u52a8\u8109\u75be\u75c5\u6210\u4eba\u60a3\u8005\uff0c\u4ee5\u9884\u9632\u52a8\u8109\u7ca5\u6837\u786c\u5316\u8840\u6813\u6027\u4e8b\u4ef6\u53d1\u751f\uff0c\u5c06\u9996\u5148\u5728\u5fb7\u56fd\u4e0a\u5e02\u3002<\/span>
<\/p>\n

8\u3001\u8fd1\u65e5\uff0c\u8f89\u745e\u516c\u5e03ATTR-ACT\u7814\u7a76\u7684\u6570\u636e\u663e\u793a\uff0c\u8be5\u4e34\u5e8a3\u671f\u7814\u7a76\u4e2dtafamidis\u964d\u4f4e\u4e86\u60a3\u800530%\u7684\u6b7b\u4ea1\u98ce\u9669\uff0c\u4f7f\u8fd9\u79cd\u836f\u7269\u6709\u673a\u4f1a\u6210\u4e3a\u6cbb\u7597\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u5fc3\u808c\u75c5\u7b2c\u4e00\u4e2a\u83b7\u5f97\u6279\u51c6\u7684\u836f\u7269\u3002<\/span><\/p>\n

9\u3001\u4e13\u6ce8\u764c\u75c7\u4e13\u5229\u836f\u7269\u5f00\u53d1\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8Cantex Pharmaceuticals\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u5df2\u6388\u4e88\u516c\u53f8\u5728\u7814\u836f\u7269CX-01\u7528\u4e8e\u63a5\u53d7\u8bf1\u5bfc\u6cbb\u7597\u65b0\u8bca\u65ad\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff0960\u5c81\u4ee5\u4e0a\u60a3\u8005\u6cbb\u7597\u7684\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\u3002<\/span><\/p>\n

10\u3001\u8bfa\u534e\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5176\u5728\u7814\u836f\u7269\u03b1\u7279\u5f02\u6027PI3K\u6291\u5236\u5242BYL719\uff08alpelisib\uff09\uff0c\u5728\u5168\u7403\u8fdb\u884c\u76843\u671fSOLAR-1\u8bd5\u9a8c\u4e2d\uff0c\u8fbe\u5230\u4e86\u6539\u5584\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u8fd9\u4e00\u4e3b\u8981\u7ec8\u70b9\u3002<\/span><\/p>\n

11\u3001\u7f57\u6c0f\u96c6\u56e2\u6210\u5458\u57fa\u56e0\u6cf0\u514b\u5ba3\u5e03\uff0c\u51763\u671f\u7814\u7a76HAVEN 3\u7684\u5173\u952e\u6570\u636e\u53d1\u8868\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08NEJM\uff09\u4e0a\u3002\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86\u5728\u4f53\u5185\u4e0d\u542b\u56e0\u5b50VIII\u6291\u5236\u7269\u768412\u5c81\u53ca\u4ee5\u4e0aA\u578b\u8840\u53cb\u75c5\u60a3\u8005\u4e2d\uff0c\u6bcf\u5468\u6216\u6bcf\u4e24\u5468\u65bd\u7528\u4e00\u6b21Hemlibra\uff08emicizumab-kxwh\uff09\u8fdb\u884c\u9884\u9632\u6027\u6cbb\u7597\u7684\u7597\u6548\u3002<\/span><\/p>\n

12\u3001\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u5ba3\u5e03FDA\u63a5\u53d7\u4e86\u8be5\u516c\u53f8\u4e3aSprycel\uff08dasatinib\uff0c\u8fbe\u6c99\u66ff\u5c3c\uff09\u9012\u4ea4\u7684\u8865\u5145\u4e0a\u5e02\u7533\u8bf7\u3002\u5b83\u5c06\u4e0e\u5316\u7597\u8054\u7528\uff0c\u7528\u4e8e\u6cbb\u7597\u65b0\u786e\u8bca\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\uff08Ph+\uff09\u7684\u6025\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\uff08ALL\uff09\u513f\u7ae5\u60a3\u8005\u3002FDA\u6709\u671b\u57282018\u5e7412\u670829\u65e5\u4e4b\u524d\u505a\u51fa\u56de\u590d\u3002<\/span><\/p>\n

13\u3001Bausch Health\u516c\u53f8\u65d7\u4e0b\u76ae\u80a4\u79d1\u5904\u65b9\u836f\u516c\u53f8Ortho Dermatologics\u516c\u5e03\u79f0\uff0c\u7f8e\u56fdFDA\u5df2\u63a5\u53d7\u4e86DUOBRII\u6d17\u5242\uff08\u5364\u500d\u4ed6\u7d22\u4e19\u9178\u916f\u548c\u4ed6\u624e\u7f57\u6c40\uff0c\u53c8\u79f0IDP-118\uff09\u7528\u4e8e\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u5c40\u90e8\u6cbb\u7597\u7684\u65b0\u836f\u4e0a\u5e02\u7684\u91cd\u65b0\u7533\u8bf7\u3002\u6b64\u6b21\u7533\u8bf7\u5c5e\u4e8e\u7f8e\u56fdFDA\u836f\u7269\u7684II\u7c7b\u518d\u7533\u8bf7\uff0cPDUFA\u65e5\u671f\u4e3a2019\u5e742\u670815\u65e5\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c30\u671f\uff09\"<\/p>\n

14\u3001\u5f00\u53d1\u8f6c\u5316\u7597\u6cd5\u6765\u6cbb\u7597\u8870\u5f31\u6027\u6ccc\u5c3f\u7cfb\u7edf\u75be\u75c5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8TARIS\u5ba3\u5e03\uff0c\u5176TAR-302\u4e34\u5e8a\u7814\u7a76\u83b7\u5f97\u4e86\u826f\u597d\u7684\u521d\u6b65\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\uff0c\u7528\u4e8e\u5bf9\u53e3\u670d\u7597\u6cd5\u96be\u6cbb\u7684\u7279\u53d1\u6027\u8180\u80f1\u8fc7\u5ea6\u6d3b\u52a8\u75c7\uff08OAB\uff09\u60a3\u8005\u3002<\/span>
<\/p>\n

15\u3001Ionis\u516c\u53f8\u53cd\u4e49RNA\u836f\u7269Waylivra\uff08volanesorsen\uff09\u6b63\u5728\u63a5\u53d7\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u52a0\u62ff\u5927\u7684\u76d1\u7ba1\u5ba1\u67e5\u3002\u4eca\u5e745\u6708\uff0c\u7f8e\u56fdFDA\u4ee3\u8c22\u4e0e\u5185\u5206\u6ccc\u4ea7\u54c1\u59d4\u5458\u4f1a\u4ee512:8\u7684\u6295\u7968\u7ed3\u679c\uff0c\u652f\u6301\u6279\u51c6Ionis\u65d7\u4e0bAkcea Therapeutics\u516c\u53f8Waylivra\u7528\u4e8e\u5bb6\u65cf\u6027\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\u7efc\u5408\u5f81\uff08FCS\uff09\u7684\u6cbb\u7597\u3002\u7136\u800c\u4e0d\u5e78\u7684\u662f\uff0c8\u670827\u65e5FDA\u53d1\u5e03\u4e86\u4e00\u5c01\u5b8c\u6574\u56de\u5e94\u51fd\uff08CRL\uff09\uff0c\u62d2\u7edd\u6279\u51c6Waylivra\u6cbb\u7597FCS\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u3002<\/span><\/p>\n

\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n
<\/section>\n

1\u3001\u6d59\u6c5f\u4eac\u65b0\u836f\u4e1a\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u516c\u53f8\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7b7e\u53d1\u7684\u76d0\u9178\u666e\u62c9\u514b\u7d22\u7247\uff08\u89c4\u683c0.25mg\u548c1.0mg\uff09\u836f\u54c1\u6ce8\u518c\u6279\u4ef6\u3002<\/span>
<\/p>\n

2\u3001\u8fd1\u65e5\uff088 \u6708 24 \u65e5\uff09\uff0cInsight \u6570\u636e\u5e93\u663e\u793a\uff0c\u548c\u8bb0\u9ec4\u57d4 1 \u7c7b\u9776\u5411\u6297\u764c\u836f\u544b\u55b9\u66ff\u5c3c\u4e0a\u5e02\u7533\u8bf7\u7684\u5ba1\u6279\u72b6\u6001\u5df2\u7ecf\u53d8\u66f4\u4e3a\u300c\u5728\u5ba1\u6279\u300d\uff0c\u4f9d\u7167\u4ee5\u5f80\u7ecf\u9a8c\uff0c\u9884\u8ba1\u5728\u4e0b\u6708\u53ef\u83b7\u6279\u4e0a\u5e02\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c30\u671f\uff09\"<\/p>\n

3\u30018\u670827\u65e5\uff0c\u4f17\u751f\u836f\u4e1a\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u516c\u53f8\u5df2\u4e8e\u8fd1\u65e5\u6536\u5230\u56fd\u5bb6\u836f\u76d1\u5c40\u6838\u53d1\u7684\u4e00\u7c7b\u521b\u65b0\u836fZSP1273\u300a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u300b\uff0c\u8be5\u836f\u662f\u56fd\u5185\u7b2c\u4e00\u4e2a\u83b7\u6279\u4e34\u5e8a\u7684\u6d41\u611f\u75c5\u6bd2 RNA \u805a\u5408\u9176\u6291\u5236\u5242\u3002<\/span>
<\/p>\n

4\u3001\u767e\u6d4e\u795e\u5dde8\u670827\u65e5\u5ba3\u5e03\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5df2\u53d7\u7406zanubrutinib\uff08BTK\u6291\u5236\u5242\uff09\u4f5c\u4e3a\u9488\u5bf9\u590d\u53d1\/\u96be\u6cbb\u6027\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\u6f5c\u5728\u7597\u6cd5\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u3002Zanubrutinib\u7531\u767e\u6d4e\u795e\u5dde\u4f4d\u4e8e\u4e2d\u56fd\u5317\u4eac\u7684\u79d1\u7814\u4e2d\u5fc3\u53d1\u73b0\uff0c\u76ee\u524d\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u5168\u7403\u8303\u56f4\u5bf9\u5176\u4f5c\u4e3a\u5355\u836f\u53ca\u4e0e\u5176\u4ed6\u7597\u6cd5\u8054\u5408\u7528\u836f\u6cbb\u7597\u591a\u79cd\u8840\u6db2\u6076\u6027\u80bf\u7624\u8fdb\u884c\u5f00\u53d1\u3002<\/span><\/p>\n

5\u30018 \u6708 27 \u65e5\uff0cCDE \u627f\u529e\u767e\u5965\u6cf0\u751f\u7269\u963f\u8fbe\u6728\u5355\u6297\u6ce8\u5c04\u6db2\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u9996\u4e2a\u56fd\u4ea7\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u7269\u6210\u529f\u51fa\u7ebf\uff0c\u8d76\u8d85\u5176\u4f5926\u5bb6\u77e5\u540d\u836f\u4f01\uff01<\/span><\/p>\n

6\u3001\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u53a6\u95e8\u827e\u5fb7\u751f\u7269\u533b\u836f\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0\u201c\u827e\u5fb7\u751f\u7269\u201d\uff09\u7684\u65b0\u4e00\u4ee3\u591a\u57fa\u56e0\u8054\u5408\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u5546\u54c1\u540d\uff1a\u827e\u60e0\u5065\uff09\u4e0a\u5e02\uff0c\u8be5\u8bd5\u5242\u76d2\u53ef\u68c0\u6d4b\u80ba\u764cEGFR\u3001ALK\u3001ROS1\u3001KRAS\u3001BRAF\u3001HER-2\u3001RET\u3001MET\u3001NRAS\u3001PIK3CA\u7b49\u6838\u5fc3\u9a71\u52a8\u57fa\u56e0\uff0c\u662f\u827e\u5fb7\u751f\u7269\u7ee7\u80ba\u764c\u4e09\u57fa\u56e0\u8054\u5408\uff08EGFR\/ALK\/ROS1\uff09\u68c0\u6d4b\u4ea7\u54c1\u548c\u80a0\u764c\u7cfb\u5217\u57fa\u56e0\u8054\u5408\uff08KRAS\/NRAS\u3001KRAS\/NRAS\/BRAF\u3001KRAS\/NRAS\/BRAF\/PIK3CA\uff09\u68c0\u6d4b\u4ea7\u54c1\u4e4b\u540e\uff0c\u7b2c\u4e94\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u591a\u57fa\u56e0\u8054\u5408\u68c0\u6d4b\u4ea7\u54c1\uff0c\u5c06\u57fa\u4e8ePCR\u5e73\u53f0\u7684\u80bf\u7624\u591a\u57fa\u56e0\u8054\u5408\u5feb\u901f\u68c0\u6d4b\u63a8\u5411\u4e86\u53c8\u4e00\u4e2a\u9ad8\u5cf0\uff01<\/span><\/p>\n

\u673a\u5236\/\u9776\u70b9\u7814\u7a76\u8fdb\u5c55<\/span><\/section>\n
<\/section>\n

1\u3001\u8fd1\u65e5\uff0c\u7531\u7f8e\u56fd\u56fd\u5bb6\u8fc7\u654f\u548c\u4f20\u67d3\u75c5\u7814\u7a76\u6240\uff08NIAID\uff09\u514d\u75ab\u8c03\u8282\u5b9e\u9a8c\u5ba4\u548c\u514d\u75ab\u9057\u4f20\u5b66\u5b9e\u9a8c\u5ba4\u7684\u79d1\u5b66\u5bb6\u4eec\u9996\u6b21\u8868\u660e\uff0c\u5728\u67d0\u4e9b\u827e\u6ecb\u75c5\u75c5\u6bd2\u611f\u67d3\u8005\u4e2d\uff0c\u4e00\u79cd\u53eb\u505a\u514d\u75ab\u7403\u86cb\u767dG3\uff08IgG3\uff09\u7684\u6297\u4f53\u53ef\u4ee5\u963b\u6b62\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684B\u7ec6\u80de\uff08\u5916\u90e8\u94fe\u63a5\uff09\u5b8c\u6210\u6b63\u5e38\u7684\u6297\u75c5\u539f\u4f53\u5de5\u4f5c\u3002\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u8fd9\u79cd\u73b0\u8c61\u4f3c\u4e4e\u662f\u8eab\u4f53\u8bd5\u56fe\u51cf\u5c11\u56e0HIV\u5b58\u5728\u5f15\u8d77\u7684\u514d\u75ab\u7cfb\u7edf\u8fc7\u5ea6\u6d3b\u8dc3\u6240\u5bfc\u81f4\u7684\u6f5c\u5728\u7834\u574f\u6027\u5f71\u54cd\u7684\u4e00\u79cd\u65b9\u5f0f\uff0c\u4f46\u8fd9\u6837\u505a\u4e5f\u4f1a\u635f\u5bb3\u6b63\u5e38\u7684\u514d\u75ab\u529f\u80fd\u3002\u5176\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728\u300aNature Immunology\u300b\u4e0a\uff0c\u9898\u4e3a”IgG3 regulates tissue-like memory B cells in HIV-infected individuals”\u3002<\/span>
<\/p>\n

2\u3001\u300aNEJM\u300b\u6742\u5fd7\u6700\u8fd1\u62a5\u9053\u4e86\u4e00\u9879\u7a81\u7834\u6027\u6210\u679c\uff1a\u5fb7\u514b\u8428\u65af\u5927\u5b66MD Anderson\u764c\u75c7\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0cPD-1\u5355\u6297Opdivo(nivolumab)\u8054\u5408CTLA-4\u5355\u6297Yervoy(ipilimumab)\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u8111\u8f6c\u79fb\uff0c\u5728\u4e2d\u4f4d\u968f\u8bbf14.0\u4e2a\u6708\u768494\u4f8b\u60a3\u8005\u4e2d\uff0c\u6269\u6563\u5230\u5176\u5927\u8111\u4e2d\u7684\u9ed1\u8272\u7d20\u7624\u8303\u56f4\u5f97\u5230\u663e\u8457\u7f29\u5c0f\u3002<\/span><\/p>\n

3\u3001\u4eba\u7c7b\u80da\u80ce\u7684\u57fa\u56e0\u7f16\u8f91\u5728\u8fc7\u53bb\u51e0\u5e74\u4e2d\u9010\u6e10\u88ab\u4eba\u4eec\u6240\u63a5\u53d7\u3002\u8fd1\u65e5\uff0c\u6765\u81ea\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u7684\u9ec4\u884c\u8bb8\u6559\u6388\u548c\u5e7f\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e09\u533b\u9662\u7684\u5218\u89c1\u6865\u6559\u6388\u9886\u5bfc\u7684\u7814\u7a76\u5c0f\u7ec4\u5229\u7528\u6700\u65b0CRISPR\u6280\u672f\u6210\u529f\u7ea0\u6b63\u4e86\u80da\u80ce\u4e2d\u7684\u9a6c\u51e1\u7efc\u5408\u75c7\uff08MFS\uff09\u81f4\u75c5\u7a81\u53d8\u3002\u8fd9\u4e00\u7814\u7a76\u6210\u679c\u4ee3\u8868\u7740\u5728\u91cd\u5851\u4eba\u7c7b\u80da\u80ceDNA\u7684\u7814\u7a76\u4e0a\u53d6\u5f97\u4e86\u91cd\u5927\u7a81\u7834\u30028\u670813\u65e5\uff0c\u8fd9\u9879\u6210\u679c\u4ee5\u201cCorrectionof the Marfan Syndrome pathogenic FBN1 mutation by base editing in human cellsand heterozygous embryos\u201d\u4e3a\u9898\u53d1\u8868\u5728\u300aMolecular Therapy\u300b\u6742\u5fd7\u4e0a\u3002\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u7684\u9ec4\u884c\u8bb8\u6559\u6388\u548c\u5e7f\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e09\u533b\u9662\u7684\u5218\u89c1\u6865\u6559\u6388\u4e3a\u8fd9\u4e00\u7814\u7a76\u7684\u901a\u8baf\u4f5c\u8005\u3002<\/span><\/p>\n

4\u3001\u8fd1\u65e5\u9876\u5c16\u5b66\u672f\u671f\u520a\u300a\u79d1\u5b66\u300b\u4e0a\uff0c\u520a\u53d1\u4e86\u4e00\u9879\u91cd\u91cf\u7ea7\u7684\u6587\u7ae0\u3002\u6765\u81ea\u5fb7\u514b\u8428\u65af\u5927\u5b66\u897f\u5357\u533b\u5b66\u4e2d\u5fc3\u7684Eric Olson\u6559\u6388\u56e2\u961f\u8bc1\u5b9e\uff0c\u5229\u7528CRISPR\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff0c\u6211\u4eec\u6709\u671b\u6cbb\u7597\uff0c\u751a\u81f3\u662f\u6839\u6cbb\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u3002\u8fd9\u4e00\u8bbe\u60f3\u5df2\u5728\u5927\u578b\u52a8\u7269\u4e2d\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002CRISPR\u6280\u672f\u7684\u9886\u519b\u4eba\u7269\u4e4b\u4e00Jennifer Doudna\u6559\u6388\u5728\u542c\u5230\u8fd9\u5219\u62a5\u9053\u540e\u8868\u793a\u201c\u81ea\u5df1\u96be\u4ee5\u63a7\u5236\u5174\u594b\u4e4b\u60c5\u201d\u3002<\/span><\/p>\n

5\u3001\u6765\u81ea\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\uff08HKBU\uff09\u7684\u5316\u5b66\u5bb6\u4eec\u73b0\u5728\u53d1\u73b0\u4f7f\u7528\u4e00\u79cd\u91d1\u5c5e\u5316\u5408\u7269\u53ef\u4ee5\u6291\u5236\u4e0e\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u7d27\u5bc6\u76f8\u5173\u7684\u9176\uff0c\u800cTNBC\u662f\u6700\u96be\u6cbb\u7597\u7684\u4e00\u79cd\u4e73\u817a\u764c\u3002\u8fd9\u79cd\u91d1\u5c5e\u5316\u5408\u7269\u53ef\u4ee5\u6291\u5236\u5c0f\u9f20\u4f53\u5185\u7684TNBC\u80bf\u7624\uff0c\u540c\u65f6\u6bd2\u526f\u4f5c\u7528\u5f88\u5c0f\u3002\u56e0\u6b64\u4ed6\u4eec\u7684\u5de5\u4f5c\u8fdb\u4e00\u6b65\u63ed\u5f00\u4e86TNBC\u4e2d\u8d56\u6c28\u9178\u7279\u5f02\u6027\u53bb\u7532\u57fa\u5316\u91765A\uff08KDM5A\uff09\u8fd9\u4e2a\u9176\u7684\u89d2\u8272\u3002\u8fd9\u4e2a\u5316\u5408\u7269\u5728TNBC\u6cbb\u7597\u4e2d\u5177\u6709\u5f88\u5927\u7684\u6f5c\u529b\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u4e8e\u8fd1\u65e5\u53d1\u8868\u5728\u300aAngewandte Chemie International Edition\u300b\u4e0a\uff0c\u9898\u4e3a\u201cSelective inhibition of lysine-specific demethylase 5A (KDM5A) using a rhodium complex for triple-negative breast cancer therapy\u201d\uff0c\u7531HKBU\u4e0e\u6fb3\u95e8\u5927\u5b66\u3001\u6fb3\u95e8\u79d1\u6280\u5927\u5b66\u3001\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u4ee5\u53ca\u6c5f\u82cf\u5927\u5b66\u5408\u4f5c\u5b8c\u6210\u3002<\/span><\/p>\n

\n

6\u3001\u5ca9\u85fb\u7cd6GM1\u795e\u7ecf\u8282\u82f7\u8102\u7c7b\u7cd6(FucGM1)\u662f\u5f88\u5927\u6bd4\u4f8b\u7684\u4eba\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u80bf\u7624\u4e2d\u8868\u8fbe\u7684\u80bf\u7624\u76f8\u5173\u6297\u539f\uff0c\u4f46\u662f\u5927\u591a\u6570\u6b63\u5e38\u7684\u6210\u4eba\u7ec4\u7ec7\u7f3a\u5c11\u8fd9\u4e2a\u7269\u8d28\uff0c\u56e0\u6b64\u5b83\u662f\u514d\u75ab\u80bf\u7624\u5b66\u7684\u4e00\u4e2a\u6f5c\u5728\u9776\u6807\u3002\u800c\u8fd1\u65e5\u6765\u81eaBMS\u548c\u65af\u5766\u798f\u5927\u5b66\u7b49\u673a\u6784\u7684\u7814\u7a76\u4eba\u5458\u5c31\u5f00\u53d1\u51fa\u4e86\u4e00\u79cd\u65b0\u578b\u975e\u5ca9\u85fb\u7cd6\u5316\u7684\u4eba\u6e90\u5316IgG1\u6297\u4f53BMS-986012\uff0c\u53ef\u4ee5\u7279\u5f02\u6027\u9776\u5411\u7ed3\u5408FucGM1\uff0c\u7814\u7a76\u4eba\u5458\u5728\u4e34\u5e8a\u524d\u5b9e\u9a8c\u4e2d\u8bc4\u4f30\u4e86\u5176\u6297\u764c\u7597\u6548\uff0c\u76f8\u5173\u7814\u7a76\u6210\u679c\u4e8e\u8fd1\u65e5\u53d1\u8868\u5728\u300aClin Cancer Res\u300b\u4e0a\uff0c\u9898\u4e3a\u201cA Novel, Fully Human Anti\u2013fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer\u201d\u3002<\/span>
<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001 1\u3001\u62dc\u8033\uff08Bayer\uff09\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u7684Jivi\uff08BAY94-9027\uff09\u83b7\u5f97FDA\u6279\u51c6\uff0c\u7528\u4e8e […]<\/p>\n","protected":false},"author":1,"featured_media":38763,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38762"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=38762"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38762\/revisions"}],"predecessor-version":[{"id":38768,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38762\/revisions\/38768"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/38763"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=38762"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=38762"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=38762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}