{"id":38787,"date":"2018-08-22T01:00:00","date_gmt":"2018-09-17T06:24:49","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e7%96%bc%e7%97%9b%e6%b2%bb%e7%96%97%e6%96%b0%e8%8d%af%e7%a0%94%e5%8f%91%e8%bf%9b%e5%b1%95%ef%bc%88%e4%b8%8b%ef%bc%89\/"},"modified":"2018-09-17T14:24:51","modified_gmt":"2018-09-17T06:24:51","slug":"%e7%96%bc%e7%97%9b%e6%b2%bb%e7%96%97%e6%96%b0%e8%8d%af%e7%a0%94%e5%8f%91%e8%bf%9b%e5%b1%95%ef%bc%88%e4%b8%8b%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/38787\/","title":{"rendered":"\u75bc\u75db\u6cbb\u7597\u65b0\u836f\u7814\u53d1\u8fdb\u5c55\uff08\u4e0b\uff09"},"content":{"rendered":"
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6<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u503c\u5f97\u5173\u6ce8\u7684\u65b0\u578b\u9776\u70b9\u673a\u5236<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

CGRP\u53d7\u4f53\u62ee\u6297\u5242<\/span><\/strong>
<\/p>\n

\u504f\u5934\u75db\u53d1\u4f5c\u59cb\u4e8e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff0c\u53ef\u80fd\u6d89\u53ca\u80cc\u4fa7\u8111\u6865\u3001\u4e0b\u4e18\u8111\u548c\u4e18\u8111\u7684\u533a\u57df\u3002\u4e00\u79cd\u5b66\u8bf4\u8ba4\u4e3a\u4e09\u53c9\u795e\u7ecf\u8282\u88ab\u6fc0\u6d3b\u89e6\u53d1\u523a\u6fc0\u4e09\u53c9\u795e\u7ecf\u8840\u7ba1\u901a\u8def\u7684\u4f20\u5165\u7269\u5411\u810a\u9ad3\u6295\u5c04\u5e76\u4f20\u9012\u5934\u75db\u611f\u81f3\u4e2d\u67a2\u795e\u7ecf\u662f\u5934\u75db\u7684\u75c5\u7a0b\u3002\u8fd9\u4e9b\u4f20\u5165\u7269\u7ec8\u6b62\u4e8e\u4e09\u53c9\u795e\u7ecf\u810a\u675f\u6838\u8840\u8111\u5c4f\u969c\u80cc\u4fa7\u548c\u810a\u67f1\u89d2C1\u548cC2\u80cc\u4fa7\uff0c\u7136\u540e\u7531\u4e8c\u7ea7\u795e\u7ecf\u5143\u901a\u8fc7\u4e0a\u884c\u75bc\u75db\u901a\u8def\u6295\u5c04\u75bc\u75db\u4fe1\u53f7\u81f3\u4e18\u8111\u548c\u76ae\u8d28\u533a\u57df\uff0c\u4ece\u800c\u611f\u77e5\u5934\u75db\u3002\u4e09\u53c9\u795e\u7ecf\u8282\u4e2d\u964d\u9499\u7d20\u57fa\u56e0\u76f8\u5173\u80bd\uff08CGRP\uff09\u56de\u8def\u7684\u6301\u7eed\u6fc0\u6d3b\u4f7f\u4e09\u53c9\u795e\u7ecf\u8282\u4f5c\u4e3a\u504f\u5934\u75db\u5386\u7a0b\u4e2d\u7684\u653e\u5927\u5668\u3002\u56e0\u800c\u963b\u585e\u4e09\u53c9\u795e\u7ecf\u8282\u4e2d\u7684CGRP\u4fe1\u53f7\u5c06\u662f\u6cbb\u7597\/\u9884\u9632\u504f\u5934\u75db\u7684\u9014\u5f84\u4e4b\u4e00\u3002\u591a\u9879\u7814\u7a76\u8bc1\u5b9e\u4e86CGRP\u5728\u6025\u6027\u504f\u5934\u75db\u53d1\u4f5c\u671f\u95f4\u589e\u52a0\u6709\u663e\u8457\u589e\u52a0\u3002<\/span><\/p>\n

CGRP\u662fAmara\u548cRosenfold\u7b49\u57281982\u5e74\u53d1\u73b0\u7684\u542b\u670937\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u7684\u591a\u80bd\uff0c\u6709\u03b1\u548c\u03b2\u4e24\u79cd\u7c7b\u578b\uff0c\u5206\u522b\u7531CALCA\u53caCALCB\u4e24\u4e2a\u57fa\u56e0\u7f16\u7801\u3002\u5b83\u5e7f\u6cdb\u5b58\u5728\u4e8e\u4e2d\u67a2\u548c\u5468\u56f4\u795e\u7ecf\u7cfb\u7edf\u5185\uff0c\u7279\u522b\u662f\u611f\u89c9\u795e\u7ecf\u5143\u7684\u80de\u4f53\u548c\u672b\u68a2\uff0c\u662f\u76ee\u524d\u6700\u4e3a\u5f3a\u5927\u7684\u5185\u6e90\u6027\u8840\u7ba1\u8212\u5f20\u7269\u8d28\u3002CGRP\u53d7\u4f53\u5c5e\u4e8eG\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff0c\u529f\u80fd\u6027\u53d7\u4f53\u75317\u4e2a\u8de8\u819c\u86cb\u767d\u590d\u5408\u4f53\uff08\u964d\u9499\u7d20\u53d7\u4f53\u6837\u53d7\u4f53\uff0cCALCRL\uff09\uff0c1\u4e2a\u8de8\u819c\u86cb\u767d\u53d7\u4f53\u6d3b\u6027\u4fee\u9970\u86cb\u767d\uff08\u53d7\u4f53\u6d3b\u6027\u4fee\u9970\u86cb\u767d1\uff0cRAMP1\uff09,1\u4e2a\u80de\u5185\u86cb\u767d\uff08\u53d7\u4f53\u7ec4\u5206\u86cb\u767d\uff0cRCP\uff09\u53ca\u4e00\u4e2aGs\u86cb\u767d\u03b1\u4e9a\u57fa\uff08G\u03b1s\uff09\u7ec4\u6210\u3002\u9776\u5411CGRP\u7684\u6cbb\u7597\uff0c\u5982\u6297CGRP\u6297\u4f53\uff0c\u6297CGRP\u53d7\u4f53\u6297\u4f53\u548c\u5c0f\u5206\u5b50CGRP\u53d7\u4f53\u62ee\u6297\u5242Gepants\u5747\u53ef\u8fdb\u5165\u65e0\u969c\u788d\u4e09\u53c9\u795e\u7ecf\u795e\u7ecf\u8282\u53d1\u6325\u6cbb\u7597\u4f5c\u7528\u3002<\/span><\/p>\n

\"\u75bc\u75db\u6cbb\u7597\u65b0\u836f\u7814\u53d1\u8fdb\u5c55\uff08\u4e0b\uff09\"<\/p>\n

\u56fe6\uff1aCGRP\u8fd0\u8f93\u53caCGRP\u76f8\u5173\u504f\u5934\u75db\u6cbb\u7597\u7684\u6d3b\u6027\u4f4d\u70b9\u3002a\uff1a\u4eba\u6e90\u03b1\u578bCGRP\u7684\u6c28\u57fa\u9178\u7ec4\u6210\u7ed3\u6784\u3002b: CGRP\u53d7\u4f53\u590d\u5408\u7269\u3002c:\u5728\u542b\u6709CGRP\u7684\u4e09\u53c9\u795e\u7ecf\u9759\u8109\u66f2\u5f20\u652f\u914d\u7684\u8111\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u4e2dCGRP\u76f8\u5173\u504f\u5934\u75db\u6cbb\u7597\u7684\u9776\u70b9\u3002<\/span><\/p>\n

CGRP\u53d7\u4f53\u662f\u8fd1\u5e74\u6765\u504f\u5934\u75db\u836f\u7269\u7814\u53d1\u7684\u660e\u661f\u9776\u70b9\u30022018\u5e745\u6708\uff0c\u5b89\u8fdb\u548c\u8bfa\u534e\u5408\u4f5c\u5f00\u53d1\u7684Aimovig\uff08Erenumab\uff09\u2014\u2014\u6297CGRP\u53d7\u4f53\u4eba\u6e90\u5355\u6297\uff0c\u88abFDA\u6279\u51c6\u7528\u4e8e\u6210\u4eba\u504f\u5934\u75db\u7684\u9884\u9632\u6cbb\u7597\u3002\u968f\u540e\u8be5\u836f\u5728\u6b27\u76df\u4e5f\u83b7\u5f97\u6279\u51c6\u3002\u8fd9\u662f\u7814\u53d1\u7ba1\u7ebf\u4e2d\u552f\u4e00\u9776\u5411CGRP\u53d7\u4f53\u7684\u836f\u7269\u3002Cortellis\u6570\u636e\u9884\u6d4b\u51762022\u5e74\u5168\u7403\u9500\u552e\u989d\u5c06\u8d85\u8fc710\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

\u7d27\u968f\u5176\u540e\u7684\u662f\u68af\u74e6\u5236\u836f\u7684Fremanezumab\u548c\u793c\u6765\u7684Galcanezumab\uff0c\u5747\u4e3a\u9776\u5411CGRP\u7684\u4eba\u6e90\u5316\u6297\u4f53\uff0c\u4e8c\u8005\u90fd\u4e8e2017\u5e7410\u6708\u5411FDA\u63d0\u4ea4\u4e86\u9488\u5bf9\u9884\u9632\u504f\u5934\u75db\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u57fa\u4e8e\u5176\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\u9884\u8ba1\u4eca\u5e74\u4e5f\u4f1a\u6709\u5ba1\u6279\u6d88\u606f\u4f20\u51fa\u3002Cortellis\u6570\u636e\u9884\u6d4b\u8fd9\u4e24\u4e2a\u836f\u72692022\u5e74\u5168\u7403\u9500\u552e\u989d\u5206\u522b\u4e3a9.6\u4ebf\u548c6.5\u4ebf\u7f8e\u5143\u3002\u4e0eErenumab\u4e0d\u540c\u7684\u662f\uff0c\u8fd9\u4e24\u79cd\u836f\u7269\u57fa\u4e8e\u5176\u79ef\u6781\u7684\u9488\u5bf9\u53d1\u4f5c\u6027\u4e1b\u96c6\u6027\u5934\u75db\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u6216\u53ef\u88ab\u6269\u5c55\u7528\u4e8e\u4e1b\u96c6\u6027\u5934\u75db\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\u9664\u6b64\u4e4b\u5916\uff0cAlder\u751f\u7269\u5236\u836f\u516c\u53f8\u7684Eptinezumab\u4f5c\u4e3a\u5b63\u5ea6\u7ed9\u836f\u7684\u6297CGRP\u6297\u4f53\u5df2\u53d1\u5e03\u4e24\u9879\u5173\u952e\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e2d\u671f\u6570\u636e\uff0c\u8fbe\u4e3b\u8981\u548c\u6b21\u8981\u4e34\u5e8a\u7ec8\u70b9\uff0c\u53e6\u4e00\u9879\u9488\u5bf9\u6162\u6027\u504f\u5934\u75db\u60a3\u8005\u6cbb\u7597\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u53e3\u670d\u5c0f\u5206\u5b50CGRP\u53d7\u4f53\u62ee\u6297\u5242\u67093\u4e2a\u5df2\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c BioHaven\u7684Rimegepant\u548c\u827e\u5c14\u5efa\uff08Allergan\uff09\u7684Ubrogepant\u3001Atogepant\u5df2\u5904\u4e8e\u4e34\u5e8a\u2162\u671f\u8bd5\u9a8c\u4e2d\uff0c\u5176\u4e2dRimegepant\u548cUbrogepant\u9884\u8ba1\u5c06\u57282019\u5e74\u9488\u5bf9\u504f\u5934\u75db\u6cbb\u7597\u5411FDA\u63d0\u4ea4NDA\u3002\u76ee\u524d\u9488\u5bf9\u504f\u5934\u75db\u3001\u75bc\u75db\u7684\u7814\u53d1\u7ba1\u7ebf\u4e0a\u8fd8\u65e0\u4e34\u5e8a\u2160\u3001\u2161\u671fCGRP\u53d7\u4f53\u62ee\u6297\u5242\u836f\u7269\uff0c\u67097\u4e2a\u8be5\u7c7b\u836f\u7269\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u53d1\u9636\u6bb5\uff08\u88683\uff09\u3002<\/span><\/p>\n

\u88683\uff1a\u4e34\u5e8a\u5728\u7814\u53ca\u4e0a\u5e02\u7684\u7528\u4e8e\u504f\u5934\u75db\u6cbb\u7597\u7684CGRP\u53d7\u4f53\u62ee\u6297\u5242<\/span><\/p>\n

\"\u75bc\u75db\u6cbb\u7597\u65b0\u836f\u7814\u53d1\u8fdb\u5c55\uff08\u4e0b\uff09\"<\/p>\n

NGF\uff08\u795e\u7ecf\u751f\u957f\u56e0\u5b50\uff09\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n

\u795e\u7ecf\u751f\u957f\u56e0\u5b50\uff08NGF\uff09\u5bf9\u795e\u7ecf\u7cfb\u7edf\u7684\u751f\u957f\u53d1\u80b2\u5177\u6709\u5341\u5206\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u4e3a\u795e\u7ecf\u5143\u589e\u6b96\u3001\u5206\u5316\u548c\u5b58\u6d3b\u4ee5\u53ca\u529f\u80fd\u7ef4\u6301\u6240\u5fc5\u9700\uff0c\u5e76\u80fd\u4fc3\u8fdb\u795e\u7ecf\u635f\u4f24\u540e\u7684\u4fee\u590d\u548c\u518d\u751f\u3002NGF\u4e5f\u6709\u75bc\u75db\u4fe1\u53f7\u4f20\u9012\u529f\u80fd\uff0c\u7f55\u89c1\u4eba\u4f53\u57fa\u56e0\u53d8\u5f02\u8868\u660e\u963b\u65adNGF\u6216\u5176\u53d7\u4f53TrkA\u53ef\u4ee5\u7ec8\u6b62\u75bc\u75db\u4fe1\u53f7\u3002\u5927\u91cf\u7684\u52a8\u7269\u548c\u4eba\u4f53\u5b9e\u9a8c\u8868\u660e\uff0cNGF\u6c34\u5e73\u5728\u521b\u4f24\u3001\u708e\u75c7\u548c\u6162\u6027\u75bc\u75db\u4e2d\u90fd\u6709\u6240\u5347\u9ad8\u3002\u963b\u65adNGF\u2014TrkA\u4fe1\u53f7\u53ef\u663e\u8457\u6291\u5236\u75bc\u75db\uff0c\u5e76\u4e14\u4e0d\u4f1a\u5bf9\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u9020\u6210\u4e25\u91cd\u5f71\u54cd\u3002NGF\u6297\u4f53\u662f\u5c11\u6709\u7684\u7597\u6548\u80fd\u548c\u5417\u5561\u7c7b\u836f\u7269\u5ab2\u7f8e\u4f46\u65e0\u6210\u763e\u98ce\u9669\u7684\u6b62\u75db\u836f\uff0c\u4f46\u53ef\u80fd\u5b58\u5728\u589e\u52a0\u819d\u76d6\u635f\u4f24\u7684\u98ce\u9669\u3002\u76ee\u524d\u5c1a\u65e0\u6b64\u673a\u5236\u4ea7\u54c1\u4e0a\u5e02\u3002<\/span><\/p>\n

\u636eClarivate Analytics Cortellis\u6570\u636e\uff0c\u76ee\u524d\u5728\u7814\u7684NGF\u6291\u5236\u5242\uff0c\u5747\u4e3aNGF\u6297\u4f53\uff0c\u6709\u4e24\u4e2a\u5df2\u8fdb\u5c55\u5230\u4e34\u5e8a\u2162\u671f\uff0c\u5206\u522b\u4e3a\u518d\u751f\u5143\u7684Fasinumab\u548c\u8f89\u745e\u3001\u793c\u6765\u5171\u540c\u7814\u53d1\u7684Tanezumab\u3002\u5904\u4e8e\u4e34\u5e8a\u2161\u671f\u3001\u4e34\u5e8a\u2160\u671f\u548c\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u836f\u7269\u5206\u522b\u67091\u4e2a\u3002<\/span><\/p>\n

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NGF\u6297\u4f53\u7684\u5b89\u5168\u6027\u95ee\u9898\u4f7f\u8be5\u673a\u5236\u836f\u7269\u7684\u5f00\u53d1\u5145\u6ee1\u4e0d\u786e\u5b9a\u6027\uff0c\u4eca\u5e745\u6708\u4efd\uff0c\u518d\u751f\u5143\u505c\u6b62\u4e86Fasinumab\u7528\u4e8e\u9aa8\u5173\u8282\u708e\u75bc\u75db\u6cbb\u7597\u7684\u9ad8\u5242\u91cf\u7ec4\u7684\u4e34\u5e8a\u2162\u671f\u8bd5\u9a8c\uff0c\u4f4e\u5242\u91cf\u7ec4\u5c06\u7ee7\u7eed\u8fdb\u884c\u3002\u4f46\u75bc\u75db\u9886\u57df\u5c24\u5176\u662f\u6162\u6027\u75bc\u75db\u5b58\u5728\u5de8\u5927\u7684\u5e02\u573a\u7a7a\u95f4\uff0c\u4e0d\u5c11\u4f01\u4e1a\u5bf9NGF\u6291\u5236\u5242\u8fd9\u4e00\u98ce\u9669\u4e0e\u6536\u76ca\u5e76\u5b58\u7684\u836f\u7269\u7814\u53d1\u65b9\u5411\u6000\u6709\u671f\u5180\u3002<\/span><\/p>\n

\u88684\uff1a\u4e34\u5e8a\u5728\u7814\u7684NGF\u6291\u5236\u5242<\/span><\/p>\n

\"\u75bc\u75db\u6cbb\u7597\u65b0\u836f\u7814\u53d1\u8fdb\u5c55\uff08\u4e0b\uff09\" <\/span> <\/span>SCN9A\u94a0\u79bb\u5b50\u901a\u9053\u6291\u5236\u5242<\/span><\/strong><\/p>\n

\u7535\u538b\u95e8\u63a7\u6027\u94a0\u79bb\u5b50\u901a\u9053\uff08Nav\uff09\u7684\u5185\u5411\u7535\u6d41\u662f\u4e2d\u67a2\u548c\u5916\u5468\u795e\u7ecf\u5143\u52a8\u4f5c\u7535\u4f4d\u4ea7\u751f\u548c\u4f20\u5bfc\u7684\u91cd\u8981\u73af\u8282\uff0c\u800c\u795e\u7ecf\u5143\u5174\u594b\u6027\u589e\u9ad8\u6216\u5bf9\u523a\u6fc0\u7684\u53cd\u5e94\u6027\u589e\u52a0\u662f\u5404\u79cd\u75bc\u75db\u4ea7\u751f\u53d1\u5c55\u7684\u91cd\u8981\u673a\u5236\u3002\u56e0\u6b64\uff0c\u7535\u538b\u95e8\u63a7\u6027\u94a0\u79bb\u5b50\u901a\u9053\u5728\u75bc\u75db\u4f20\u5bfc\u901a\u8def\u7279\u522b\u662f\u5728\u5916\u5468\u611f\u89c9\u795e\u7ecf\u5143\u4e2d\u7684\u4f5c\u7528\u4e00\u76f4\u662f\u75bc\u75db\u7814\u7a76\u7684\u70ed\u70b9\u3002\u4ee5\u5c40\u90e8\u9ebb\u9189\u836f\u5229\u591a\u5361\u56e0\u548c\u5e03\u6bd4\u5361\u56e0\u4e3a\u4ee3\u8868\u7684\u94a0\u79bb\u5b50\u901a\u9053\u6291\u5236\u5242\u5df2\u7ecf\u4f5c\u4e3a\u672f\u540e\u9547\u75db\u836f\u4e0a\u5e02\u3002<\/span><\/p>\n

Nav\u6309\u7167\u5176\u03b1\u4e9a\u5355\u4f4d\u7684\u4e0d\u540c\u53ef\u5206\u4e3a9\u4e2a\u4e9a\u578b\uff0c\u5206\u522b\u547d\u540d\u4e3aNav1.1\uff5eNav1.9\u3002Nav1.7\uff08SCN9A\uff09\u662fSCN9A\u7f16\u7801\u7684\u8de8\u819c\u86cb\u767d\uff0c\u9009\u62e9\u6027\u8868\u8fbe\u4e8e\u810a\u9ad3\u80cc\u6839\u795e\u7ecf\u8282\uff08DRG\uff09\u3001\u4ea4\u611f\u795e\u7ecf\u8282\u3001\u65bd\u4e07\u7ec6\u80de\u548c\u795e\u7ecf\u5185\u5206\u6ccc\u7ec6\u80de\u7684\u80de\u819c\u4e0a\uff0c\u5176\u4e2d\u5927\u91cf\u5206\u5e03\u5728\u5c0f\u76f4\u5f84\u7684\u810a\u9ad3\u80cc\u6839\u795e\u7ecf\u4e0a\uff0c\u800c\u4eba\u7c7b\u53ea\u5206\u5e03\u5728\u5916\u5468\u795e\u7ecf\u7cfb\u7edf\u4e2d\u3002\u5f53SCN9A\u57fa\u56e0\u51fa\u73b0\u65e0\u6548\u7a81\u53d8\uff0cNav1.7\u5b8c\u5168\u5931\u53bb\u529f\u80fd\uff0c\u5c06\u5bfc\u81f4\u5148\u5929\u6027\u65e0\u75db\u75c7\u3002\u591a\u9879\u4e34\u5e8a\u524d\u6570\u636e\u8868\u660e\uff0cNav1.7\u6c34\u5e73\u5728\u6025\u3001\u6162\u6027\u708e\u6027\u75bc\u75db\u548c\u795e\u7ecf\u75c5\u7406\u6027\u75bc\u75db\u52a8\u7269\u6a21\u578b\u4e2d\u5747\u6709\u6240\u5347\u9ad8\u3002<\/span><\/p>\n

\u636eCortellis\u6570\u636e\uff0c\u76ee\u524d\u5728\u7814\u7684SCN9A\u94a0\u79bb\u5b50\u901a\u9053\u6291\u5236\u5242\u5171\u670940\u4e2a\uff0c\u5176\u4e2d\u4e34\u5e8a3\u671f\u67091\u4e2a\uff0c\u4e34\u5e8a2\u671f\u67093\u4e2a\uff0c\u4e34\u5e8a1\u671f\u67097\u4e2a\uff0c\u4e34\u5e8a\u524d\u7814\u7a76\u670929\u4e2a\u3002Newron Pharmaceuticals\u7684ralfinamide\u57282009\u5e74\u9488\u5bf9\u795e\u7ecf\u6027\u8170\u75db\u5c55\u5f00\u4e86\u4e34\u5e8a\u2161b\/\u2162\u671f\u8bd5\u9a8c\uff0c\u4f46\u672a\u8fbe\u5230\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\uff0c\u76ee\u524d\u5176\u9488\u5bf9\u795e\u7ecf\u75c5\u7406\u6027\u75bc\u75db\u7684\u4e34\u5e8a\u2162\u671f\u8bd5\u9a8c\u8fd8\u5728\u8fdb\u884c\u4e2d\u3002\u767e\u5065\u7684Vixotrigine\u548cXenon Pharmaceuticals\u7684Funapide\u9488\u5bf9\u7ea2\u6591\u6027\u80a2\u75db\u548c\u5e26\u72b6\u75b1\u75b9\u540e\u9057\u795e\u7ecf\u75db\u5747\u5728\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u3002<\/span><\/p>\n

\u88685\uff1a\u4e34\u5e8a\u5728\u7814\u7684SCN9A\u94a0\u79bb\u5b50\u901a\u9053\u6291\u5236\u5242<\/span><\/p>\n

\n

*Piromelatine\uff1a\u8be5\u836f\u4e3aSCN9A\u94a0\u79bb\u5b50\u901a\u9053\u6291\u5236\u5242\uff0c\u7528\u4e8e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u3001\u5931\u7720\u75c7\u3001\u9ad8\u773c\u538b\u3001\u5f00\u89d2\u578b\u9752\u5149\u773c\u7684\u6f5c\u5728\u5e94\u7528\u3002<\/span><\/p>\n

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7<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5c0f\u7ed3<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u75bc\u75db\u5c24\u5176\u662f\u6162\u6027\u75bc\u75db\u76ee\u524d\u4ecd\u7136\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7597\u836f\u7269\uff0c\u963f\u7247\u7c7b\u836f\u7269\u7684\u6ee5\u7528\u6b63\u5728\u7ed9\u793e\u4f1a\u5e26\u6765\u8bf8\u591a\u4e0d\u826f\u5f71\u54cd\uff0c\u65b0\u9776\u70b9\u65b0\u673a\u5236\u53ca\u65b0\u578b\u7ed9\u836f\u7cfb\u7edf\u7684\u75bc\u75db\u6cbb\u7597\u836f\u7684\u7814\u53d1\u662f\u76ee\u524d\u8be5\u9886\u57df\u7684\u65b9\u5411\u3002\u5168\u7403\u548c\u6211\u56fd\u75bc\u75db\u6cbb\u7597\u836f\u7269\uff08\u5305\u62ec\u9ebb\u9189\u6027\u9547\u75db\u836f\u3001\u89e3\u70ed\u9547\u75db\u836f\u548c\u504f\u5934\u75db\u6cbb\u7597\u836f\uff09\u5e02\u573a\u7684\u6301\u7eed\u589e\u957f\u4e5f\u4f7f\u836f\u4f01\u5bf9\u8be5\u9886\u57df\u836f\u7269\u7684\u7814\u53d1\u5145\u6ee1\u70ed\u60c5\uff0c\u5168\u7403\u4e34\u5e8a\u5728\u7814\u548c\u63d0\u4ea4\u4e0a\u5e02\u6ce8\u518c\u7684\u836f\u7269\u5171\u8ba1396\u4e2a\uff0c\u4e2d\u56fd\u4e34\u5e8a\u5728\u7814\u548c\u6b63\u5728\u4e34\u5e8a\u7533\u8bf7\u7684\u75bc\u75db\u6cbb\u75971\u7c7b\u65b0\u836f\u5171\u8ba112\u4e2a\u3002\u4eca\u5e745\u6708\u4efd\uff0c\u6297CGRP\u53d7\u4f53\u4eba\u6e90\u5355\u6297Aimovig\uff08Erenumab\uff09\u88abFDA\u6279\u51c6\u7528\u4e8e\u9884\u9632\u504f\u5934\u75db\u6cbb\u7597\uff0c\u5b9e\u73b0\u4e86\u8be5\u9886\u57df\u7684\u7a81\u7834\u6027\u8fdb\u5c55\u3002\u6b64\u5916\uff0c\u8fd8\u6709\u591a\u4e2a\u975e\u9776\u5411\u963f\u7247\u7c7b\u53d7\u4f53\u7684\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\u2162\u671f\u7814\u7a76\uff0c\u5982NGF\u6291\u5236\u5242\u548cSCN9A\u94a0\u79bb\u5b50\u901a\u9053\u6291\u5236\u5242\u3002\u671f\u5f85\u8be5\u9886\u57df\u6709\u66f4\u591a\u7684\u65b0\u578b\u836f\u7269\u6765\u6ee1\u8db3\u60a3\u8005\u7684\u4e34\u5e8a\u9700\u6c42\u3002<\/span>
<\/p>\n

 <\/span>\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

1. Lars Edvinsson, Kristian Agmund Haanes, Karin Warfvinge. CGRP as the target of new migraine therapies\u2014successful translation from bench to clinic. Nature Reviews Neurology, 2018, 14:338-350.<\/span><\/p>\n

2. \u5218\u6167\u4e3d, \u674e\u840d, \u674e\u6c11. \u7535\u538b\u95e8\u63a7\u6027\u79bb\u5b50\u901a\u9053Nav1.7\u4e0e\u75bc\u75db\u7684\u7814\u7a76\u8fdb\u5c55. \u57fa\u7840\u533b\u5b66\u4e0e\u4e34\u5e8a, Basic&Clinical Medicine, 2012, 32(12): 1484-1487.<\/span><\/p>\n

3. \u7a0b\u9e23\u4f73, \u6797\u4e00\u4e39.\u795e\u7ecf\u751f\u957f\u56e0\u5b50-TrkA\u4fe1\u53f7\u901a\u8def\u5728\u75bc\u75db\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u53caTrkA\u6291\u5236\u5242\u7684\u7814\u7a76\u8fdb\u5c55. \u521b\u4f24\u5916\u79d1\u6742\u5fd7\uff0cJ Trauma Surg, 2014(16): 5:468-471.<\/span><\/p>\n


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6 \u503c\u5f97\u5173\u6ce8\u7684\u65b0\u578b\u9776\u70b9\u673a\u5236 CGRP\u53d7\u4f53\u62ee\u6297\u5242 \u504f\u5934\u75db\u53d1\u4f5c\u59cb\u4e8e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff0c\u53ef\u80fd\u6d89\u53ca\u80cc\u4fa7\u8111\u6865\u3001\u4e0b\u4e18\u8111\u548c\u4e18\u8111\u7684\u533a […]<\/p>\n","protected":false},"author":1,"featured_media":38788,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38787"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=38787"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38787\/revisions"}],"predecessor-version":[{"id":38792,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/38787\/revisions\/38792"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/38788"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=38787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=38787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=38787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}