{"id":38805,"date":"2018-08-17T01:00:00","date_gmt":"2018-09-17T06:25:03","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af-2018%e5%b9%b4%e7%ac%ac28%e6%9c%9f\/"},"modified":"2018-09-17T14:25:05","modified_gmt":"2018-09-17T06:25:05","slug":"%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af-2018%e5%b9%b4%e7%ac%ac28%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/38805\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c28\u671f"},"content":{"rendered":"
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1\u3001Amicus Therapeutics\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\uff0c\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u7f55\u89c1\u4ee3\u8c22\u6027\u75be\u75c5\u65b0\u836f\u7814\u53d1\u548c\u5546\u4e1a\u5316\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\u3002\u8be5\u516c\u53f8\u5ba3\u5e03FDA\u5df2\u6388\u4e88Galafold\uff08migalastat\uff09123mg\u786c\u80f6\u56ca\u52a0\u901f\u6279\u51c6\uff0c\u8be5\u836f\u662f\u4e00\u79cd\u53e3\u670d\u3001\u7cbe\u51c6\u533b\u7597\u836f\u7269\uff0c\u7528\u4e8e\u4f53\u5916\u68c0\u6d4b\u8bc1\u5b9e\u5b58\u5728\u7279\u5b9a\u03b1-\u534a\u4e73\u7cd6\u82f7\u9176\u57fa\u56e0\u7a81\u53d8\u7684\u6cd5\u5e03\u91cc\u75c5\uff08Fabry disease\uff09\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

2\u3001FDA\u6388\u4e88lurbinectedin\uff08PM1183\uff09\u5b64\u513f\u836f\u79f0\u53f7\uff0c\u6570\u636e\u663e\u793a\u8be5\u836f\u6cbb\u7597\u5316\u7597\u540e\u8fdb\u5c55\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u60a3\u8005\uff0c\u75be\u75c5\u6574\u4f53\u7f13\u89e3\u7387\uff08ORR\uff09\u53ef\u8fbe39.3%\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff0911.8\u4e2a\u6708\u3002<\/span><\/p>\n

3\u3001Sesen Bio\u516c\u53f8\u5ba3\u5e03\uff0c\u5176\u9886\u5934\u4ea7\u54c1Vicinium\u83b7\u5f97\u7f8e\u56fdFDA\u6388\u4e88\u7684\u5feb\u901f\u901a\u9053\u8d44\u683c\uff0c\u7528\u4e8e\u6cbb\u7597\u5bf9\u5361\u4ecb\u82d7\uff08BCG\uff09\u65e0\u7f13\u89e3\u7684\u9ad8\u5206\u7ea7\u975e\u808c\u5c42\u6d78\u6da6\u6027\u8180\u80f1\u764c\uff08high grade NMIBC\uff09\u60a3\u8005\u3002Vicinium\u76ee\u524d\u6b63\u57283\u671f\u4e34\u5e8a\u8bd5\u9a8cVISTA\u4e2d\u8fdb\u884c\u8bc4\u4f30\uff0c\u7528\u4e8e\u6cbb\u7597\u9ad8\u5206\u7ea7NMIBC\u60a3\u8005\uff0c\u4ed6\u4eec\u4e4b\u524d\u66fe\u63a5\u53d7\u8fc7\u4e24\u4e2a\u7597\u7a0b\u7684BCG\u6cbb\u7597\uff0c\u4f46\u73b0\u5728BCG\u672a\u80fd\u7ee7\u7eed\u5e26\u6765\u7f13\u89e3\u3002<\/span><\/p>\n

4\u3001\u7f57\u6c0f\u65d7\u4e0b\u57fa\u56e0\u6cf0\u514b\u65e5\u524d\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u5df2\u6388\u4e88Xolair\u00ae\uff08omalizumab\uff0c\u5965\u9a6c\u73e0\u5355\u6297\uff09\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u9884\u9632\u610f\u5916\u63a5\u89e6\u4e00\u79cd\u6216\u591a\u79cd\u98df\u7269\u4f1a\u5bfc\u81f4\u4e25\u91cd\u8fc7\u654f\u53cd\u5e94\u7684\u60a3\u8005\u3002\u8fd9\u4e5f\u662f\u57fa\u56e0\u6cf0\u514b\u836f\u7269\u83b7\u5f97\u7b2c23\u6b21\u7a81\u7834\u7597\u6cd5\u6307\u5b9a\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

5\u30018\u670813\u65e5\uff0c\u7f8e\u56fd\u751f\u7269\u5236\u836f\u516c\u53f8Stemline Therapeutics\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u5df2\u7ecf\u63a5\u53d7\u4e86\u516c\u53f8Elzonristm\uff08tagraxofusp; SL-401\uff09\u7528\u4e8e\u6bcd\u7ec6\u80de\u6027\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u72b6\u7ec6\u80de\u80bf\u7624\uff08BPDCN\uff09\u6cbb\u7597\u7684\u751f\u7269\u5236\u54c1\u4e0a\u5e02\u7533\u8bf7\uff08BLA\uff09\uff0c\u5e76\u540c\u65f6\u6388\u4e88\u8be5\u7533\u8bf7\u4f18\u5148\u5ba1\u8bc4\u8ba4\u5b9a\uff0cPDUFA\u65e5\u671f\u5b9a\u57282019\u5e742\u670821\u65e5\u3002<\/span><\/p>\n

6\u3001\u65e5\u524d\uff0c\u518d\u751f\u5143\uff08Regeneron\uff09\u516c\u53f8\u9ec4\u6591\u53d8\u6027\u836f\u7269Eylea\uff08Aflibercept\uff0c\u963f\u67cf\u897f\u666e\uff09\u7684\u8865\u5145\u7533\u8bf7\u906d\u5230\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u62d2\u7edd\u3002Eylea\u7684\u8fd9\u4efd\u8865\u5145\u6279\u51c6\u5e0c\u671b\u53ef\u4ee5\u7533\u8bf7\u5c06\u8be5\u836f\u7269\u7528\u4e8e\u6bcf12\u5468\u4e00\u6b21\u7684\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08AMD\uff09\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

7\u3001\u603b\u90e8\u4f4d\u4e8e\u52a0\u5ddeOakland\u5e02\u7684OrthoTrophix\u53d1\u5e03\u4e86\u4e00\u9879\u5176\u5728\u7814\u65b0\u836fTPX100\u7684\u4e34\u5e8a2\u671f\u8bd5\u9a8c\u7684\u4e8b\u540e\u5206\u6790\u7ed3\u679c\u3002\u4f9d\u636e\u65e5\u5e38\u751f\u6d3b\u4e2d\u7684KOOS\uff08Knee injury and Osteoarthritis Outcome Score\uff09\u529f\u80fd\uff0c55%\u7684\u9aa8\u6027\u5173\u8282\u708e\uff08OA\uff09\u60a3\u8005\u5728\u819d\u5173\u8282\u529f\u80fd\u5f97\u5230\u4e86\u4e34\u5e8a\u610f\u4e49\u4e0a\u6539\u5584\u7684\u540c\u65f6\uff0c\u819d\u5173\u8282\u8f6f\u9aa8\u7684\u4f53\u79ef\u548c\u539a\u5ea6\u4e5f\u6709\u663e\u8457\u589e\u52a0\u3002<\/span><\/p>\n

8\u3001\u7f8e\u56fdFDA\u5ba3\u5e03\u6279\u51c6\u536b\u6750\uff08Eisai\uff09\u516c\u53f8\u7814\u53d1\u7684lenvatinib\u4f5c\u4e3a\u6cbb\u7597\u65e0\u6cd5\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\uff08hepatocellular carcinoma\uff0cHCC\uff09\u7684\u4e00\u7ebf\u7597\u6cd5\u3002\u8fd9\u662f\u5728\u83b7\u5f97\u6279\u51c6\u6cbb\u7597\u7532\u72b6\u817a\u764c\u548c\u80be\u764c\u4e4b\u540e\uff0clenvatinib\u6dfb\u52a0\u7684\u6700\u65b0\u9002\u5e94\u75c7\u3002<\/span><\/p>\n

9\u3001\u65e5\u524d\uff0cSun Pharma\u5ba3\u5e03FDA\u6279\u51c6\u4e86\u5176Cequa\uff08\u73af\u5b62\u7d20\u6ef4\u773c\u6db2\uff090.09%\uff0c\u7528\u4e8e\u63d0\u9ad8\u6cea\u6db2\u4ea7\u91cf\uff0c\u6cbb\u7597\u5e72\u71e5\u6027\u89d2\u819c\u7ed3\u819c\u708e\uff08\u5e72\u773c\u75c7\uff09\u3002Sun Pharma\u7684Cequa\u662f\u4e00\u6b3e\u73af\u5b62\u7d20A\uff08CsA\uff09\u7eb3\u7c73\u80f6\u675f\u5236\u5242\u3002<\/span><\/p>\n

10\u3001Vertex Pharmaceuticals\u516c\u53f88\u670816\u65e5\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u6279\u51c6KALYDECO\u00ae\uff08ivacaftor\uff09\u7528\u4e8e\u60a3\u6709\u56ca\u6027\u7ea4\u7ef4\u5316\uff08CF\uff0912-24\u4e2a\u6708\u7684\u5a74\u513f\uff0c\u60a3\u513f\u57fa\u4e8e\u4e34\u5e8a\u548c\/\u6216\u4f53\u5916\u6d4b\u5b9a\u6570\u636e\u663e\u793a\u5176\u56ca\u6027\u7ea4\u7ef4\u5316\u8de8\u819c\u4f20\u5bfc\u8c03\u8282\u56e0\u5b50\uff08CFTR\uff09\u57fa\u56e0\u4e2d\u81f3\u5c11\u6709\u4e00\u4e2a\u7a81\u53d8\u5bf9KALYDECO\u6709\u53cd\u5e94\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

11\u30018\u670814\u65e5\uff0cMotif Bio\u516c\u5e03\uff0c\u7f8e\u56fdFDA\u5df2\u7ecf\u63a5\u53d7\u4e86iclaprim\u7684NDA\uff0c\u8fd9\u662f\u4e00\u6b3e\u9488\u5bf9\u9769\u5170\u9633\u6027\u83cc\u7684\u9776\u5411\u836f\u7269\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u7ec6\u83cc\u6027\u76ae\u80a4\u548c\u76ae\u80a4\u7ed3\u6784\u611f\u67d3\uff08ABSSSI\uff09\u3002\u9488\u5bf9\u6b64\u6b21NDA\u7533\u8bf7\uff0c\u7f8e\u56fdFDA\u786e\u5b9a\u7684PDUFA\u65e5\u671f\u4e3a2019\u5e742\u670813\u65e5\u3002<\/span><\/p>\n

12\u3001\u603b\u90e8\u4f4d\u4e8e\u9a6c\u8428\u8bf8\u585e\u5ddeWaltham\u5e02\u7684Entasis Therapeutics\u8fd1\u65e5\u516c\u5e03\u4e86\u5176\u6297\u751f\u7d20\u7ec4\u5408\u7597\u6cd5ETX2514SUL\u5728\u591a\u56fd\u8fdb\u884c\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u79ef\u6781\u9876\u7ebf\u6210\u679c\u3002ETX2514SUL\u7531\u03b2-\u5185\u9170\u80fa\u9176\u6291\u5236\u5242ETX2514\u4e0e\u8212\u5df4\u5766\uff08sulbactam\uff09\u7ec4\u6210\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u6742\u6027\u5c3f\u8def\u611f\u67d3\uff08cUTI\uff09\uff0c\u5305\u62ec\u6210\u4eba\u6025\u6027\u80be\u76c2\u80be\u708e\uff08\u80be\u810f\u611f\u67d3\uff09\u3002<\/span><\/p>\n

13\u3001\u5f3a\u751f\u516c\u53f8\uff08Johnson & Johnson\uff09\u65d7\u4e0b\u7684\u6768\u68ee\u516c\u53f8\uff08Janssen Pharmaceutical\uff09\u786e\u8ba4\uff0c\u5176\u4e0e\u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09\u65d7\u4e0b\u516c\u53f8ViiV Healthcare\u5408\u4f5c\u7684\u5168\u74033\u671f\u7814\u7a76ATLAS\u53d6\u5f97\u4e86\u79ef\u6781\u7684\u9876\u7ebf\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u4f7f\u7528\u4e86\u9996\u4e2a\u7528\u4e8e\u6cbb\u7597HIV-1\u7684\u957f\u6548\u53ef\u6ce8\u5c04\u53cc\u836f\u6cbb\u7597\u65b9\u6848\uff082DR\uff09\u3002<\/span><\/p>\n

14\u3001\u518d\u751f\u5143\uff08Regeneron Pharmaceuticals\uff09\u516c\u53f8\u4e0e\u68af\u74e6\uff08Teva Pharmaceutical Industries\uff09\u516c\u53f8\u8054\u5408\u5ba3\u5e03\uff0c\u53cc\u65b9\u5171\u540c\u7814\u53d1\u7684fasinumab\u5728\u6cbb\u7597\u56e0\u81c0\u90e8\u548c\u819d\u76d6\u9aa8\u6027\u5173\u8282\u708e\uff08osteoarthritis\uff0cOA\uff09\u5bfc\u81f4\u7684\u6162\u6027\u75bc\u75db\u7684\u4e34\u5e8a3\u671f\u8bd5\u9a8c\u4e2d\u8fbe\u5230\u5171\u540c\u4e3b\u8981\u7ec8\u70b9\u4ee5\u53ca\u6240\u6709\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u3002\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u63a5\u53d7fasinumab\u6cbb\u7597\u7684\u60a3\u8005\u611f\u53d7\u5230\u7684\u75bc\u75db\u660e\u663e\u51cf\u8f7b\uff0c\u800c\u4e14\u8fd0\u52a8\u80fd\u529b\u83b7\u5f97\u663e\u8457\u6539\u5584\u3002<\/span><\/p>\n


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1\u30018\u670814\u65e5\uff0c\u6052\u745e\u533b\u836f1\u7c7b\u65b0\u836f\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u7247\u83b7CFDA\u6279\u51c6\u4e0a\u5e02\u3002\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u662f\u4e00\u79cd\u53e3\u670d\u7684\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u548c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u916a\u6c28\u9178\u6fc0\u9176\u7684\u53cc\u91cd\u6291\u5236\u5242\uff0c\u901a\u8fc7\u963b\u6b62\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08HER\uff09\u5bb6\u65cf\uff08EGFR\u3001HER2\u3001HER3\u548cHER4\uff09\u4fe1\u53f7\u901a\u8def\u8f6c\u5bfc\uff0c\u8fbe\u5230\u6297\u764c\u76ee\u7684\u3002<\/span><\/p>\n

2\u30018\u670815\u65e5\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6b63\u5f0f\u6279\u51c6\u4e86\u7f57\u6c0f\u7684\u65b0\u4e00\u4ee3ALK\u6291\u5236\u5242\u5b89\u5723\u838e\uff08\u5316\u5b66\u901a\u7528\u540d\uff0c\u963f\u6765\u66ff\u5c3c\uff09\u8fdb\u53e3\u6ce8\u518c\u7533\u8bf7\uff0c\u7528\u4e8e\u6cbb\u7597\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/span><\/p>\n

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3\u3001\u5bf9\u4e8e\u94c2\u8010\u836f\u578b\u5375\u5de2\u764c\u6cbb\u7597\uff0c\u7528\u836f\u9009\u62e9\u975e\u5e38\u6709\u9650\uff0c\u56e0\u6b64\uff0c\u4e34\u5e8a\u4e0a\u901a\u8fc7\u5bfb\u627e\u65b0\u7684\u6709\u6548\u836f\u7269\u6cbb\u7597\u94c2\u8010\u836f\u60a3\u8005\u663e\u5f97\u5c24\u4e3a\u8feb\u5207\u3002\u8fd1\u65e5\uff0c\u7531\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u79d1\u7814\u56e2\u961f\u7814\u53d1\u7684\u4e00\u79cd\u65b0\u578b\u836f\u7269\u7ec4\u5408\u65b9\u6848”\u963f\u5e15\u66ff\u5c3c+\u4f9d\u6258\u6cca\u82f7”\u80fd\u591f\u4f7f\u665a\u671f\u5375\u5de2\u764c\u60a3\u8005\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u7ffb\u500d\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728\u56fd\u9645\u9876\u7ea7\u80bf\u7624\u5b66\u6742\u5fd7\u300aLancet Oncology\u300b\uff08\u67f3\u53f6\u5200\u00b7\u80bf\u7624\uff09\u3002<\/span><\/p>\n


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1\u3001\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Science Advances\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u9274\u522b\u51fa\u4e86\u4e24\u4e2aHIV\u7597\u6cd5\u7684\u6f5c\u5728\u65b0\u578b\u836f\u7269\u9776\u70b9\u3002\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u4e00\u9879\u5c0f\u89c4\u6a21\u7684\u521d\u6b65\u7814\u7a76\uff0c\u4ed6\u4eec\u5bf919\u540dHIV\u548c\u4e19\u809d\u5171\u611f\u67d3\u60a3\u8005\u8fdb\u884c\u7814\u7a76\u53d1\u73b0\uff0c\u5f531\u578b\u5e72\u6270\u7d20\u5b58\u5728\u65f6\uff0c\u540d\u4e3aCMPK2\u548cBCLG\u8fd9\u4e24\u4e2a\u57fa\u56e0\u5c31\u4f1a\u88ab\u9009\u62e9\u6027\u5730\u6fc0\u6d3b\uff0c1\u578b\u5e72\u6270\u7d20\u66fe\u7ecf\u662f\u6cbb\u7597\u4e19\u809d\u7684\u4e00\u7ebf\u7279\u6b8a\u836f\u7269\u3002\u7814\u7a76\u8868\u660e\uff0cCMPK2\u548cBCLG\u57fa\u56e0\u5728\u5e72\u6270\u7d20\u6291\u5236HIV\u6c34\u5e73\u7684\u8fc7\u7a0b\u4e2d\u626e\u6f14\u7740\u5173\u952e\u89d2\u8272\uff0c\u56e0\u6b64\u7814\u7a76\u4eba\u5458\u6709\u671b\u5229\u7528\u8fd9\u4e24\u4e2a\u57fa\u56e0\u4f5c\u4e3a\u6f5c\u5728\u9776\u70b9\u6765\u5f00\u53d1\u6cbb\u7597HIV\u611f\u67d3\u7684\u65b0\u578b\u7597\u6cd5\u3002<\/span><\/p>\n

3\u3001\u7531\u56fd\u9645\u77e5\u540d\u533b\u7597\u4e2d\u5fc3\u8d1d\u65af\u4ee5\u8272\u5217\u6267\u4e8b\u533b\u7597\u4e2d\u5fc3\uff08BIDMC\uff09\u9886\u5bfc\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u4e09\u6c27\u5316\u4e8c\u7837\u548c\u89c6\u9ec4\u9178\u8054\u5408\u4f5c\u7528\uff0c\u53ef\u4ee5\u6709\u6548\u7684\u6297\u51fb\u764c\u75c7\uff0c\u80fd\u4e3a\u4e0d\u540c\u7c7b\u578b\u7684\u764c\u75c7\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u3002\u5176\u7ed3\u679c\u53d1\u8868\u57288\u67089\u65e5\u56fd\u9645\u8457\u540d\u671f\u520a\u300aNature Communications\u300b\u4e0a\uff0c\u9898\u4e3a”Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells”\u3002<\/span><\/p>\n

4\u3001Deepmind\u53d1\u5e03\u4e86\u4e0e\u4f26\u6566\u6469\u5c14\u83f2\u5c14\u5179\u773c\u79d1\u533b\u9662\uff08Moorfields Eye Hospital\uff09\u5408\u4f5c\u7684\u7b2c\u4e00\u9636\u6bb5\u6210\u679c\uff0c\u8fd9\u53ef\u80fd\u4f1a\u6539\u53d8\u773c\u75be\u7684\u6cbb\u7597\u65b9\u5f0f\u4e0e\u7406\u5ff5\u3002\u76ee\u524d\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u5df2\u5728\u300aNature Medicine\u300b\u4e0a\u5728\u7ebf\u53d1\u5e03\u3002Deepmind\u56e2\u961f\u8868\u793a\uff0cAI\u7cfb\u7edf\u80fd\u591f\u4ee5\u524d\u6240\u672a\u6709\u7684\u51c6\u786e\u5ea6\u5feb\u901f\u89e3\u8bfb\u5e38\u89c4\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u773c\u7403\u626b\u63cf\u7ed3\u679c\uff0c\u53ef\u4ee5\u51c6\u786e\u63a8\u8350\u60a3\u670950\u4f59\u79cd\u5371\u5bb3\u89c6\u529b\u7684\u773c\u75c5\u60a3\u8005\u8fdb\u884c\u8f6c\u8bca\u6cbb\u7597\uff0c\u51c6\u786e\u7a0b\u5ea6\u53ef\u4ee5\u5ab2\u7f8e\u4e16\u754c\u9876\u7ea7\u7684\u4e13\u5bb6\u533b\u751f\u3002<\/span><\/p>\n

\n

5\u3001\u963f\u62c9\u5df4\u9a6c\u5927\u5b66\u4f2f\u660e\u7ff0\u5206\u6821\uff08UAB\uff09\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u4e00\u79cd\u4ece\u5927\u9ebb\u4e2d\u63d0\u53d6\u7684\u836f\u7269\u6210\u5206\u2014\u2014\u5927\u9ebb\u4e8c\u915a(Cannabidiol\uff0c\u4e5f\u79f0CBD)\uff0c\u5bf9\u4e8e\u6cbb\u7597\u8010\u836f\u6027\u766b\u75eb\u662f\u6709\u6548\u7684\u3002\u8be5\u7814\u7a76\u62a5\u544a\u53d1\u8868\u4e8e\u300a\u766b\u75eb\u4e0e\u884c\u4e3a\u300b(Epilepsy and Behavior)\u6742\u5fd7\u4e0a\u3002\u636e\u5408\u4f17\u56fd\u9645\u793e\u62a5\u9053\uff0c\u7814\u7a76\u4eba\u5458\u5728\u62a5\u544a\u4e2d\u6307\u51fa\uff0cCBD\u53ef\u6709\u6548\u964d\u4f4e\u90a3\u4e9b\u5bf9\u4f20\u7edf\u7597\u6cd5\u5177\u6709\u8010\u836f\u6027\u766b\u75eb\u60a3\u8005\u7684\u53d1\u75c5\u6b21\u6570\u3002<\/span><\/p>\n

6\u3001\u8fd1\u65e5\uff0c\u7531\u4e0a\u6d77\u590d\u661f\u533b\u836f\u53caZPG Pharma\u5171\u540c\u6295\u8d44\u521b\u5efa\u7684\u590d\u661f\u5f18\u521b\uff08\u82cf\u5dde\uff09\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\u8054\u5408\u7231\u5c14\u5170\u56fd\u7acb\u9ad8\u5a01\u5927\u5b66\u9886\u5bfc\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u6291\u5236IRE1 RNase\u6d3b\u6027\u8c03\u8282\u80bf\u7624\u7ec6\u80de\u7684\u5206\u6ccc\u7ec4\u53ef\u4ee5\u589e\u5f3a\u5316\u836f\u5bf9\u80bf\u7624\u7684\u54cd\u5e94\uff0c\u8fd9\u4e00\u53d1\u73b0\u5c06\u6709\u52a9\u4e8e\u6539\u5584\u670d\u7528\u5316\u836f\u540e\u5f15\u8d77\u7684\u5206\u6ccc\u7ec4\u53d8\u5316\u5bfc\u81f4\u7684\u80bf\u7624\u590d\u53d1\uff0c\u66f4\u52a0\u6709\u6548\u7684\u6297\u51fb\u764c\u75c7\uff0c\u4e3a\u63d0\u9ad8\u5316\u7597\u6548\u679c\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u3002\u5176\u7ed3\u679c\u53d1\u8868\u57288\u670815\u65e5\u56fd\u9645\u8457\u540d\u671f\u520a\u300aNature Communications\u300b\u4e0a\uff0c\u9898\u4e3a”Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy”\u3002<\/span><\/p>\n

7\u3001\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Molecular Psychiatry\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u7b2c\u4e09\u519b\u533b\u5927\u5b66\u548c\u5357\u6fb3\u5927\u5229\u4e9a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u6216\u6709\u671b\u5f00\u53d1\u51fa\u6cbb\u7597\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u548c\u5176\u5b83\u795e\u7ecf\u53d8\u6027\u75be\u75c5\u7684\u65b0\u578b\u7597\u6cd5\uff0c\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5728\u7ec6\u80de\u4e2d\u53d1\u73b0\u4e86\u4e00\u79cd\u7279\u6b8a\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u5176\u6216\u80fd\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u9776\u70b9\u5e2e\u52a9\u7814\u7a76\u8005\u5f00\u53d1\u51fa\u6f5c\u5728\u836f\u7269\u6765\u963b\u65ad\u60a3\u8005\u673a\u4f53\u5927\u8111\u7684\u9000\u5316\uff0c\u5e76\u6539\u5584\u5176\u5b66\u4e60\u548c\u8bb0\u5fc6\u80fd\u529b\u3002<\/span><\/p>\n

8\u3001\u6700\u8fd1\u4e00\u9879\u65b0\u7684\u201c\u5173\u4e8e\u963f\u7c73\u4ec0\u75c5\u53d1\u751f\u53f2\u65b9\u9762\u7684\u7814\u7a76\u7ed3\u679c\u201d\u6216\u8bb8\u80fd\u591f\u4e3a\u8fd9\u79cd\u81f4\u6b7b\u6027\u7684\u75be\u75c5\u7684\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u3002\u963f\u7c73\u4ec0\u75c5\u662f\u4e00\u79cd\u5728\u5a74\u513f\u7fa4\u4f53\u4e2d\u9ad8\u53d1\u7684\u808c\u8089\u7cfb\u7edf\u7d0a\u4e71\u75be\u75c5\uff0c\u8be5\u75be\u75c5\u7684\u53d1\u751f\u4e0eTNNT1\u57fa\u56e0\u7684\u7a81\u53d8\u4e4b\u95f4\u5b58\u5728\u660e\u663e\u8054\u7cfb\u3002\u8fd9\u9879\u7814\u7a76\u603b\u7ed3\u4e86\u4ece1923\u5e74\u52302017\u5e74\u4e4b\u95f4\u8be5\u75be\u75c5\u53d1\u751f\u7684\u8c31\u7cfb\u7279\u5f81\u3001\u4e34\u5e8a\u6570\u636e\u4ee5\u53ca\u5206\u5b50\u673a\u5236\u65b9\u9762\u7684\u7814\u7a76\u4e0e\u62a5\u9053\u3002\u76f8\u5173\u7ed3\u679c\u53d1\u8868\u5728\u6700\u8fd1\u4e00\u671f\u7684\u300aJournal of Human Molecular Genetics\u300b\u6742\u5fd7\u4e0a\uff0c\u6587\u7ae0\u4f5c\u8005\u6765\u81eaSpecial Children\u4e34\u5e8a\u7814\u7a76\u4e2d\u5fc3\u3002<\/span><\/p>\n

9\u3001\u300a\u81ea\u7136\u300b\u6742\u5fd7\u4e0a\u520a\u767b\u4e86\u4e00\u9879\u534e\u4eba\u5b66\u8005\u7684\u91cd\u78c5\u7814\u7a76\u3002\u6765\u81ea\u897f\u5948\u5c71\u4f0a\u574e\u533b\u5b66\u9662\u7684Bo Chen\u6559\u6388\u56e2\u961f\u4f7f\u7528\u518d\u751f\u7597\u6cd5\uff0c\u8ba9\u7f79\u60a3\u5148\u5929\u6027\u773c\u76f2\u7684\u5c0f\u9f20\u9996\u6b21\u89c1\u5230\u4e86\u5149\u660e\uff01\u5b9e\u9a8c\u5206\u4e3a\u4e24\u6b65\uff0c\u7b2c\u4e00\u6b65\u662f\u901a\u8fc7\u5728\u773c\u775b\u91cc\u6ce8\u5c04\u7279\u5b9a\u7684\u57fa\u56e0\uff0c\u6fc0\u6d3b\u03b2-catenin\u86cb\u767d\u3002\u51e0\u5468\u540e\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u518d\u5f80\u773c\u775b\u91cc\u6ce8\u5c04\u5176\u4ed6\u5173\u952e\u7684\u8f6c\u5f55\u56e0\u5b50\u57fa\u56e0\uff0c\u4fc3\u8fdb\u89c6\u6746\u7ec6\u80de\u7684\u751f\u6210\u3002\u5728\u663e\u5fae\u955c\u4e0b\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u6e05\u695a\u5730\u770b\u5230\u4e86\u65b0\u5f62\u6210\u7684\u89c6\u6746\u7ec6\u80de\u3002\u5b83\u4eec\u4e0e\u666e\u901a\u7ec6\u80de\u7684\u7ed3\u6784\u770b\u6765\u6ca1\u6709\u5dee\u5f02\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u8fd8\u89c2\u5bdf\u5230\u4e86\u65b0\u7a81\u89e6\u7684\u5f62\u6210\uff0c\u8868\u660e\u65b0\u751f\u6210\u7684\u90a3\u4e9b\u7ec6\u80de\uff0c\u53ef\u80fd\u6709\u7740\u6b63\u5e38\u7ec6\u80de\u7684\u751f\u7406\u529f\u80fd\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\uff0c\u8bc1\u5b9e\u4e86\u8fd9\u4e2a\u4ee4\u4eba\u5174\u594b\u7684\u89c2\u70b9\u3002\u7814\u7a76\u4eba\u5458\u4eec\u5728\u7f79\u60a3\u5148\u5929\u6027\u773c\u76f2\u7684\u5c0f\u9f20\u4e2d\u4f7f\u7528\u4e86\u8fd9\u79cd\u518d\u751f\u7597\u6cd5\uff0c\u5e76\u89c2\u5bdf\u5230\u4e86\u540c\u6837\u7684\u7ed3\u679c\u2014\u2014\u5b83\u4eec\u7684\u773c\u775b\u91cc\u957f\u51fa\u4e86\u65b0\u7684\u89c6\u6746\u7ec6\u80de\uff0c\u800c\u4e14\u8fd9\u4e9b\u7ec6\u80de\u53ef\u4ee5\u548c\u89c6\u7f51\u819c\u795e\u7ecf\u5143\u8fdb\u884c\u6c9f\u901a\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u65e0\u8bba\u662f\u5bf9\u89c6\u7f51\u819c\u795e\u7ecf\u8282\u7ec6\u80de\u3001\u8fd8\u662f\u5bf9\u5927\u8111\u7684\u5206\u6790\uff0c\u90fd\u8868\u660e\u8fd9\u4e9b\u5c0f\u9f20\u5bf9\u5149\u4ea7\u751f\u4e86\u53cd\u5e94\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u8fd9\u4e9b\u4e00\u51fa\u751f\u5c31\u773c\u76f2\u7684\u5c0f\u9f20\uff0c\u6709\u751f\u4ee5\u6765\u7b2c\u4e00\u6b21\u89c1\u5230\u4e86\u5149\u660e\u3002<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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