{"id":38831,"date":"2018-08-13T01:00:00","date_gmt":"2018-09-17T06:25:19","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af-2018%e5%b9%b4%e7%ac%ac27%e6%9c%9f\/"},"modified":"2018-09-17T14:25:21","modified_gmt":"2018-09-17T06:25:21","slug":"%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af-2018%e5%b9%b4%e7%ac%ac27%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/38831\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c27\u671f"},"content":{"rendered":"
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\"\u6bcf\u5468\u836f\u8baf<\/p>\n

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1\u3001\u8f89\u745e\u8fd1\u65e5\u5ba3\u5e03\uff0c\u6b27\u76df\u59d4\u5458\u4f1a\uff08EC\uff09\u5df2\u6279\u51c6\u66f2\u59a5\u73e0\u5355\u6297\u751f\u7269\u4eff\u5236\u836fTrazimera\uff0c\u7528\u4e8eHER2\u9633\u6027\u4e73\u817a\u764c\u53caHER2\u9633\u6027\u8f6c\u79fb\u6027\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u817a\u764c\u7684\u6cbb\u7597\u3002Trazimera\u9488\u5bf9\u7684\u54c1\u724c\u836f\u4e3a\u7f57\u6c0f\u7684Herceptin\uff08\u8d6b\u8d5b\u6c40\uff0c\u901a\u7528\u540d\uff1atrastuzumab\uff0c\u66f2\u59a5\u73e0\u5355\u6297\uff09\u3002<\/span><\/p>\n

2\u3001\u8bfa\u534e\u65d7\u4e0b\u4eff\u5236\u836f\u5355\u5143\u5c71\u5fb7\u58eb\u8fd1\u65e5\u5ba3\u5e03\uff0c\u6b27\u76df\u59d4\u5458\u4f1a\uff08EC\uff09\u5df2\u6279\u51c6\u751f\u7269\u4eff\u5236\u836fHyrimoz\uff08adalimumab\uff0c\u963f\u8fbe\u6728\u5355\u6297\uff09\u7528\u4e8e\u827e\u4f2f\u7ef4\u54c1\u724c\u836f\u4fee\u7f8e\u4e50\uff08Humira\uff0c\u963f\u8fbe\u6728\u5355\u6297\uff09\u6240\u6709\u9002\u5e94\u75c7\uff0c\u5305\u62ec\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff08RA\uff09\u3001\u6591\u5757\u578b\u94f6\u5c51\u75c5\u3001\u514b\u7f57\u6069\u75c5\u3001\u8461\u8404\u819c\u708e\u548c\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08UC\uff09\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cHyrimoz\u662f\u5c71\u5fb7\u58eb\u5728\u8fc7\u53bb18\u4e2a\u6708\u5185\u5728\u6b27\u76df\u6279\u51c6\u7684\u7b2c4\u4e2a\u3001\u5168\u7403\u8303\u56f4\u5185\u6279\u51c6\u7684\u7b2c7\u4e2a\u751f\u7269\u4eff\u5236\u836f\u3002<\/span><\/p>\n

3\u3001\u963f\u65af\u5229\u5eb7\u8fd1\u65e5\u5ba3\u5e03\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u5df2\u6388\u4e88selumetinib\u6cbb\u75971\u578b\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\uff08NF1\uff09\u7684\u5b64\u513f\u836f\u8d44\u683c\u3002\u5728\u7f8e\u56fd\u65b9\u9762\uff0cFDA\u5728\u4eca\u5e742\u6708\u4e5f\u6388\u4e88\u4e86selumetinib\u6cbb\u7597NF1\u7684\u5b64\u513f\u836f\u8d44\u683c\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

selumetinib<\/strong><\/span><\/p>\n

4\u3001\u7f57\u6c0f\u5ba3\u5e03\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u6388\u4e88\u5176\u5728\u7814\u836f\u7269RG6042\uff08\u66fe\u7528\u540dIONIS-HTTRx\uff09\u4f18\u5148\u836f\u54c1\uff08PRIME\uff09\u8d44\u683c\uff0c\u7528\u4e8e\u6cbb\u7597\u4ea8\u5ef7\u987f\u75c5\uff08HD\uff09\u3002\u5728\u4e00\u98791\/2a\u671f\u7814\u7a76\u4e2d\uff0cRG6042\u5c55\u793a\u4e86\u51cf\u5c11\u81f4\u75c5\u6027\u7a81\u53d8\u4ea8\u5ef7\u987f\u86cb\u767d\uff08mHTT\uff09\u7684\u80fd\u529b\u3002<\/span><\/p>\n

5\u3001Ovid Therapeutics\u516c\u53f8\u8fd1\u65e5\u5ba3\u5e03\u4e86\u9488\u5bf9\u5929\u4f7f\u4eba\u7efc\u5408\u5f81\u7684\u65b0\u836fOV101\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8cSTARS\u7684\u79ef\u6781\u9876\u7ebf\u6570\u636e\u3002\u6570\u636e\u663e\u793aOV101\u8fbe\u5230\u4e86\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\u7684\u4e3b\u8981\u7ec8\u70b9\u3002\u5bf9\u6bd4\u5b89\u6170\u5242\u7ec4\uff0c\u6bcf\u65e5\u63a5\u53d7\u4e00\u6b21\u836f\u7269\u7684\u5242\u91cf\u7ec4\u5728\u7b2c12\u5468\u53d6\u5f97\u4e86\u9996\u4e2a\u9884\u671f\u7597\u6548\u7ec8\u70b9\uff08\u5305\u62ec\u4e34\u5e8a\u5168\u7403\u5370\u8c61\u6539\u5584\u91cf\u8868CGI-I\uff09\uff0c\u4e14\u6709\u660e\u663e\u7684\u5927\u5e45\u6539\u5584\uff08p=0.0006\uff09\u3002\u8be5\u8bd5\u9a8c\u836f\u5728\u6210\u4eba\u4e0e\u9752\u5c11\u5e74\u5929\u4f7f\u4eba\u7efc\u5408\u5f81\u60a3\u8005\u8eab\u4e0a\u7686\u4f53\u73b0\u51fa\u4e86\u826f\u597d\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\uff0c\u5176\u8bd5\u9a8c\u6570\u636e\u5c06\u63a8\u52a8OV101\u7684\u540e\u671f\u53d1\u5c55\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

6\u30018\u67088\u65e5\uff0cSangamo Therapeutics\u516c\u5e03\u4e86\u65d7\u4e0bcDNA\u57fa\u56e0\u7597\u6cd5\u5019\u9009\u836f\u7269SB-525\u7528\u4e8eA\u578b\u8840\u53cb\u75c5\u6cbb\u7597\u7684\u4e34\u5e8a1\/2\u671f\u7814\u7a76\uff08Alta\uff09\u7684\u521d\u6b65\u79ef\u6781\u7ed3\u679c\u3002Sangamo\u548c\u8f89\u745e\u901a\u8fc7\u5168\u7403\u5408\u4f5c\u5171\u540c\u8d1f\u8d23SB-525\u7684\u4e34\u5e8a\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u3002<\/span><\/p>\n

7\u3001\u534f\u548c\u53d1\u9175\u9e92\u9e9f\u682a\u5f0f\u4f1a\u793e\u7684Poteligeo\uff08mogamulizumab\uff09\u5728\u8fd1\u65e5\u901a\u8fc7\u4e86\u7f8e\u56fdFDA\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u548c\u4f18\u5148\u5ba1\u8bc4\u3002\u9002\u5e94\u75c7\u4e3a\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u6b21\u5168\u8eab\u6027\u7597\u6cd5\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u8548\u6837\u771f\u83cc\u75c5\uff08mycosis fugoides, MF\uff09\u6216\u585e\u624e\u91cc\u7efc\u5408\u75c7\uff08Sezary syndrome, SS\uff09\u6210\u5e74\u60a3\u8005\u3002<\/span><\/p>\n

8\u3001\u65e5\u524d\uff0cParatek Pharmaceuticals\u5ba3\u5e03\u7f8e\u56fdFDA\u7684\u6297\u5fae\u751f\u7269\u836f\u7269\u54a8\u8be2\u59d4\u5458\u4f1a\u6295\u7968\u8d5e\u6210\u6279\u51c6\u9759\u8109\u6ce8\u5c04\uff08IV\uff09\u548c\u53e3\u670domadacycline\uff0c\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u7ec6\u83cc\u6027\u76ae\u80a4\u548c\u76ae\u80a4\u7ed3\u6784\u611f\u67d3\uff08ABSSSI\uff09\uff0817\u6bd41\u7968\uff09\uff0c\u4ee5\u53ca\u793e\u533a\u83b7\u5f97\u6027\u7ec6\u83cc\u6027\u80ba\u708e\uff08CABP\uff09\uff0814\u6bd44\u7968\uff09\u3002\u9884\u8ba1FDA\u5c06\u4e8e\u4eca\u5e7410\u6708\u521d\u505a\u51fa\u51b3\u5b9a\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

9\u30018\u670811\u65e5\uff0c\u7f8e\u56fdFDA\u5ba3\u5e03\u6279\u51c6Onpattro\uff08patisiran\uff09\u8f93\u6ce8\u6cbb\u7597\uff0c\u7528\u4e8e\u7531\u9057\u4f20\u6027\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u6dc0\u7c89\u6837\u53d8\u6027\uff08hATTR\uff09\u5f15\u8d77\u7684\u5468\u56f4\u795e\u7ecf\u75be\u75c5\uff08\u591a\u53d1\u6027\u795e\u7ecf\u75c5\uff0cpolyneuropathy\uff09\u6210\u4eba\u60a3\u8005\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u662fFDA\u6279\u51c6\u7684\u9996\u6b3e\u7528\u4e8e\u6cbb\u7597\u7531hATTR\u5f15\u8d77\u7684\u591a\u53d1\u6027\u795e\u7ecf\u75c5\u60a3\u8005\u7684\u7597\u6cd5\uff0c\u4e5f\u662fFDA\u6279\u51c6\u7684\u9996\u6b3e\u5c0f\u5e72\u6270RNA\uff08siRNA\uff09\u836f\u7269\u3002<\/span><\/p>\n

10\u3001\u8fd1\u65e5\uff0cApotex\u516c\u53f8\u65d7\u4e0b\u4e0d\u540c\u5242\u91cf\u7684\u6c2f\u5316\u94be\u53e3\u670d\u6db2\u83b7\u5f97\u4e86\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u5ba1\u6279\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u5bb6\u516c\u53f8\u7684\u6c2f\u5316\u94be\u53e3\u670d\u6db2\u6210\u4e3a\u4e86\u9996\u4f8b\u901a\u8fc7\u201c\u7ade\u4e89\u4eff\u5236\u7597\u6cd5\u201d\u6e20\u9053\u6700\u7ec8\u83b7\u5f97\u6279\u51c6\u7684\u4eff\u5236\u836f\u7269\u3002\u8fd9\u4e00\u65b0\u7684\u6279\u51c6\u9014\u5f84\u662f\u5728\u7f8e\u56fd\u7279\u6717\u666e\u63a8\u5d07\u7684\u836f\u4ef7\u6539\u9769\u653f\u7b56\u4e0b\u63a8\u51fa\u7684\uff0c\u65e8\u5728\u52a0\u901f\u5f00\u53d1\u548c\u5ba1\u6279\u7f3a\u4e4f\u7ade\u4e89\u836f\u54c1\u7684\u4eff\u5236\u836f\u3002<\/span><\/p>\n

11\u3001\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u534e\u76db\u987f\u7279\u533a\u768460\u00b0 Pharmaceuticals(60P)\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u5f00\u53d1\u70ed\u5e26\u75be\u75c5\u836f\u7269\u7684\u751f\u7269\u533b\u836f\u516c\u53f8\u300260P\u8fd1\u65e5\u5ba3\u5e03\uff0cFDA\u6279\u51c6\u4e86\u5176ARAKODA\u2122(tafenoquine)\u7247\u5242\u7528\u4e8e\u5728\u6210\u4eba\u4e2d\u9884\u9632\u759f\u75be\u3002\u8fd9\u662f18\u5e74\u6765FDA\u6279\u51c6\u7684\u9996\u4f8b\u7528\u4e8e\u9884\u9632\u759f\u75be\u7684\u65b0\u836f\u3002<\/span><\/p>\n

12\u3001\u8fd1\u65e5\uff0cFDA\u5ba3\u5e03\u6279\u51c6Poteligeo\uff08mogamulizumab-kpkc\uff09\u4e0a\u5e02\uff0c\u6cbb\u7597\u5df2\u7ecf\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u6b21\u5168\u8eab\u6027\u7597\u6cd5\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u8548\u6837\u771f\u83cc\u75c5\uff08mycosis fugoides, MF\uff09\u6216\u585e\u624e\u91cc\u7efc\u5408\u75c7\uff08Sezary syndrome, SS\uff09\u6210\u5e74\u60a3\u8005\u3002\u8fd9\u662fFDA\u7b2c\u4e00\u6b21\u6279\u51c6\u9488\u5bf9SS\u7684\u836f\u7269\uff0c\u5b83\u540c\u65f6\u4e3aMF\u60a3\u8005\u63d0\u4f9b\u4e86\u66f4\u591a\u6cbb\u7597\u9009\u62e9\u3002<\/span><\/p>\n

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\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n
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1\u30018\u67086\u65e5\uff0c\u5409\u5229\u5fb7\u79d1\u5b66\u516c\u53f8\u5ba3\u5e03\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u6377\u6276\u5eb7\uff08\u827e\u8003\u6069\u4e19\u66ff\u7247\uff0c\u5373E\/C\/F\/TAF\uff09\u7528\u4e8e\u6cbb\u7597HIV-1\u611f\u67d3\uff0c\u4f7f\u6377\u6276\u5eb7\u6210\u4e3a\u4e2d\u56fd\u9996\u4e2a\u6279\u51c6\u7684\u57fa\u4e8eTAF\/FTC\u3001\u7528\u4e8e\u6cbb\u7597HIV\u7684\u5355\u4e00\u7247\u5242\uff08STR\uff09\u65b9\u6848\uff0c\u4e5f\u662f\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u7684\u9002\u7528\u4e8e\u6210\u5e74\u548c\u9752\u5c11\u5e74HIV\u611f\u67d3\u7684\u542b\u6709TAF\/FTC\u7684\u5b8c\u6574\u65b9\u6848\u3002<\/span><\/p>\n

2\u3001\u6c5f\u82cf\u6052\u745e\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u8fd1\u65e5\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u516c\u53f8\u6536\u5230\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u901a\u77e5\uff0c\u6052\u745e\u533b\u836f\u5411\u7f8e\u56fdFDA\u7533\u62a5\u7684\u6258\u4f10\u666e\u5766\u7247\uff08\u89c4\u683c\u4e3a15mg\u300130mg\uff09\u7b80\u7565\u65b0\u836f\u7533\u8bf7\uff08ANDA\uff0c\u5373\u7f8e\u56fd\u4eff\u5236\u836f\u7533\u8bf7\uff09\u5df2\u83b7\u5f97\u6682\u65f6\u6279\u51c6\u3002<\/span><\/p>\n

3\u3001\u8fd1\u65e5\uff0c\u6d59\u6c5f\u534e\u6d77\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u63a7\u80a1\u5b50\u516c\u53f8\u4e0a\u6d77\u534e\u5965\u6cf0\u751f\u7269\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u91cd\u7ec4\u5168\u4eba\u6e90\u6297\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u7684\u300a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u300b\u3002<\/span><\/p>\n

4\u30018\u670811\u65e5\uff0c\u9e3f\u8fd0\u534e\u5b81\uff08\u676d\u5dde\uff09\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\u5ba3\u5e03\uff1a\u81ea\u4e3b\u5f00\u53d1\u7684\u539f\u7814\u65b0\u836f\u2014\u2014\u91cd\u7ec4\u6297\u4ebaGLP-1\u53d7\u4f53\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\uff08\u683c\u9c81\u5854\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u4ee3\u53f7\uff1aGMA102\uff09\u8fd1\u65e5\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u9881\u53d1\u7684\u9488\u5bf92\u578b\u7cd6\u5c3f\u75c5\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

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8\u3001\u5b89\u8fdb\u4e2d\u56fd\u5ba3\u5e03\uff0c\u745e\u767e\u5b89\u00ae\uff08\u82f1\u6587\u540dRepatha\u00ae\uff0c\u901a\u7528\u540d\u4f9d\u6d1b\u5c24\u5355\u6297evolocumab\uff09\u6ce8\u5c04\u6db2\u5df2\u4e8e7\u670831\u65e5\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08\u539f\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\uff09\u6279\u51c6\uff0c\u6210\u4e3a\u9996\u4e2a\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u621612\u5c81\u4ee5\u4e0a\u9752\u5c11\u5e74\u7eaf\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08HoFH\uff09\u7684PCSK9\u6291\u5236\u5242\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

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10\u3001\u8fd1\u65e5\uff0c\u6d59\u6c5f\u6d77\u6b63\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u63a7\u80a1\u5b50\u516c\u53f8\u6d77\u6b63\u836f\u4e1a\uff08\u676d\u5dde\uff09\u6709\u9650\u516c\u53f8\u6536\u5230\u7f8e\u56fdFDA\u7684\u901a\u77e5\uff0c\u6d77\u6b63\u676d\u5dde\u516c\u53f8\u5411\u7f8e\u56fdFDA\u7533\u62a5\u7684\u76d0\u9178\u591a\u5948\u54cc\u9f50\u53e3\u5d29\u7247\u7684\u65b0\u836f\u7b80\u7565\u7533\u8bf7\u5df2\u83b7\u5f97\u6279\u51c6\uff0c\u6807\u5fd7\u7740\u516c\u53f8\u5177\u5907\u4e86\u5728\u7f8e\u56fd\u5e02\u573a\u9500\u552e\u8be5\u4ea7\u54c1\u7684\u8d44\u683c\uff0c\u5bf9\u516c\u53f8\u62d3\u5c55\u7f8e\u56fd\u5e02\u573a\u5e26\u6765\u79ef\u6781\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

11\u30012018\u5e748\u67086\u65e5\uff0c\u8f89\u745e\u516c\u53f8\u5b98\u7f51\u516c\u5e03\uff0c\u5168\u7403\u9996\u4e2a\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176\uff08CDK\uff094\/6\u6291\u5236\u5242\u7231\u535a\u65b0\u00ae IBRANCE\u00ae\uff08\u54cc\u67cf\u897f\u5229, palbociclib\uff09\u5df2\u4e8e7\u670831\u65e5\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u3002\u636e\u4e86\u89e3\uff0c\u7231\u535a\u65b0\u00ae\u9002\u7528\u4e8e\u6cbb\u7597\u6fc0\u7d20\u53d7\u4f53\uff08HR\uff09\u9633\u6027\u3001\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53 2\uff08HER2\uff09\u9634\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff0c\u5e94\u4e0e\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u4f5c\u4e3a\u7edd\u7ecf\u540e\u5973\u6027\u60a3\u8005\u7684\u521d\u59cb\u5185\u5206\u6ccc\u6cbb\u7597\u3002<\/span><\/p>\n

\n
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\u673a\u5236\/\u9776\u70b9\u7814\u7a76\u8fdb\u5c55<\/span><\/section>\n
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<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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1\u3001\u8fd1\u65e5\uff0c\u7ebd\u7ea6\u5927\u5b66\u533b\u5b66\u9662\u7684\u79d1\u5b66\u5bb6\u4eec\u5728T\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\uff08T-ALL\uff09\u4e2d\uff0c\u53d1\u73b0NOTCH-1\u4fe1\u53f7\u901a\u8def\u53ef\u4ee5\u52ab\u6301\u70ed\u4f11\u514b\u8f6c\u5f55\u56e0\u5b501\uff08HSF1\uff09\u4fe1\u53f7\u901a\u8def\uff0c\u9884\u793a\u963b\u65adHSF1\u4fe1\u53f7\u901a\u8def\u4e2d\u7684\u4e00\u4e2a\u6216\u591a\u4e2a\u57fa\u56e0\u53ef\u80fd\u662f\u6cbb\u7597\u8fd9\u4e00\u6076\u6027\u75be\u75c5\u7684\u65b0\u9014\u5f84\u3002\u5176\u8bd5\u9a8c\u7ed3\u679c\u4e8e\u8fd1\u65e5\u53d1\u8868\u5728\u300aNature Medicine\u300b\u6742\u5fd7\u4e0a\uff0c\u8fd9\u662f\u7b2c\u4e00\u6b21\u53d1\u73b0\u6fc0\u6d3bHSF1\u4fe1\u53f7\u901a\u8def\u4e0e\u4e00\u79cd\u767d\u8840\u75c5\u76f4\u63a5\u76f8\u5173\u3002<\/span><\/p>\n

2\u3001Emory\u5927\u5b66Winship\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u6700\u8fd1\u53d1\u73b0\u4e86\u4e00\u79cd\u4f7f\u80bf\u7624\u53ca\u764c\u7ec6\u80de\u7cfb\u4ea7\u751f\u987a\u94c2\u6297\u6027\u7684\u9176\uff0c\u5e76\u53d1\u73b0\u4e86\u4e00\u6b3e\u80fd\u6291\u5236\u8fd9\u79cd\u9176\u7684\u5728\u7814\u65b0\u836flestaurtinib\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u4e8e\u8fd1\u671f\u53d1\u8868\u5728\u300aCancer Cell\u300b\u4e0a\u3002<\/span><\/p>\n

3\u3001\u6700\u8fd1\uff0c\u6765\u81ea\u897f\u73ed\u7259\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\uff08CNIO\uff09\u548c\u5fb7\u56fd\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\uff08DKFZ\uff09\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u51e0\u5341\u5e74\u6765\u88ab\u8ba4\u4e3a\u662f\u80bf\u7624\u542f\u52a8\u5b50\u7684PLK1\u57fa\u56e0\u7adf\u7136\u53ef\u4ee5\u6291\u5236\u764c\u75c7\u7684\u53d1\u5c55\u3002\u300aNature Communications\u300b\u6742\u5fd7\u4e8e8\u67081\u65e5\u5728\u7ebf\u53d1\u8868\u4e86\u8fd9\u7bc7\u9898\u4e3a\u201cPLK1 overexpression induces chromosomal instability and suppresses tumor development\u201d\u7684\u8bba\u6587\uff0c\u8be5\u8bba\u6587\u98a0\u8986\u4e86\u5b66\u672f\u754c\u7684\u8ba4\u77e5\u3002<\/span><\/p>\n

4\u3001\u7f8e\u56fd\u7814\u7a76\u4eba\u5458\u5728\u65b0\u4e00\u671f\u82f1\u56fd\u300a\u81ea\u7136\u300b\u6742\u5fd7\u53d1\u8868\u62a5\u544a\u8bf4\uff0c\u8111\u819c\u6dcb\u5df4\u7ba1\u529f\u80fd\u969c\u788d\u53ef\u80fd\u662f\u5bfc\u81f4\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4ee5\u53ca\u5e74\u9f84\u76f8\u5173\u6027\u8ba4\u77e5\u529f\u80fd\u969c\u788d\u52a0\u91cd\u7684\u4e00\u4e2a\u5173\u952e\u56e0\u7d20\u3002\u8fd9\u4e00\u53d1\u73b0\u6709\u671b\u4e3a\u6cbb\u7597\u76f8\u5173\u75be\u75c5\u63d0\u4f9b\u65b0\u601d\u8def\u3002<\/span><\/p>\n

\n

5\u3001\u8fd1\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u751f\u7269\u5316\u5b66\u4e0e\u7ec6\u80de\u751f\u7269\u5b66\u7814\u7a76\u6240\u5468\u6ce2\u7814\u7a76\u7ec4\u4e0e\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u90d1\u4fca\u514b\u7814\u7a76\u7ec4\u5408\u4f5c\u7814\u7a76\uff0c\u5728\u56fd\u9645\u77e5\u540d\u5b66\u672f\u671f\u520a\u300a\u6b27\u6d32\u5206\u5b50\u751f\u7269\u5b66\u7ec4\u7ec7\u671f\u520a\u300b\u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u9996\u5ea6\u63ed\u793a\u4eba\u7c7b\u9752\u6625\u671f\u8d77\u59cb\u5206\u6ccc\u7684\u8111\u5782\u4f53\u6fc0\u7d20–\u4fc3\u9ec4\u4f53\u751f\u6210\u7d20\u5728\u9020\u8840\u5e72\u7ec6\u80de\u6570\u91cf\u7a33\u5b9a\u7ef4\u6301\u4e2d\u7684\u91cd\u8981\u8c03\u63a7\u529f\u80fd\u3002<\/span><\/p>\n

6\u3001\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u5eb7\u5948\u5c14\u5927\u5b66\u3001\u5f17\u5409\u5c3c\u4e9a\u5927\u5b66\u3001\u7279\u62c9\u534e\u5927\u5b66\u3001\u5bc6\u82cf\u91cc\u5927\u5b66\u3001\u5fb7\u56fd\u6b27\u6d32\u5206\u5b50\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4\u548c\u5965\u5730\u5229\u79d1\u6280\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u4e86HIV-1\u75c5\u6bd2\u7ed3\u6784\u662f\u5982\u4f55\u7ec4\u88c5\u7684\u65b0\u7ec6\u8282\uff0c\u8fd9\u4e00\u53d1\u73b0\u4e3a\u6cbb\u7597\u8fd9\u79cd\u75c5\u6bd2\u611f\u67d3\u63d0\u4f9b\u4e86\u6f5c\u5728\u7684\u65b0\u9776\u6807\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e748\u67081\u65e5\u5728\u7ebf\u53d1\u8868\u5728Nature\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cInositol phosphates are assembly co-factors for HIV-1\u201d\u3002\u8fd9\u9879\u7814\u7a76\u62a5\u9053\u4e00\u79cd\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u53d1\u73b0\u7684\u88ab\u79f0\u4f5c\u808c\u9187\u516d\u78f7\u9178\uff08inositol hexakisphosphate, IP6\uff09\u7684\u5c0f\u5206\u5b50\u5728\u8fd9\u79cd\u75c5\u6bd2\u7684\u672a\u6210\u719f\u53d1\u80b2\uff08\u5728\u88ab\u611f\u67d3\u7684\u7ec6\u80de\u5185\u53d1\u751f\uff09\u548c\u6210\u719f\u53d1\u80b2\uff08\u5728\u8fd9\u79cd\u75c5\u6bd2\u4ece\u7ec6\u80de\u819c\u4e0a\u51fa\u82bd\u5e76\u4ece\u7ec6\u80de\u4e0a\u5207\u5272\u4e0b\u6765\u540e\u53d1\u751f\uff09\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002<\/span><\/p>\n

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