{"id":39606,"date":"2018-09-07T01:00:00","date_gmt":"2018-09-17T06:33:14","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e7%b3%bb%e5%88%97%e9%87%8d%e7%a3%85%e7%bb%bc%e8%bf%b0%e8%a7%a3%e6%9e%90%e5%8e%9f%e5%88%9b%e8%8d%af%e7%89%a9%e5%a4%9a%e9%9d%b6%e7%82%b9%e4%bd%9c%e7%94%a8\/"},"modified":"2018-09-17T14:33:18","modified_gmt":"2018-09-17T06:33:18","slug":"%e7%b3%bb%e5%88%97%e9%87%8d%e7%a3%85%e7%bb%bc%e8%bf%b0%e8%a7%a3%e6%9e%90%e5%8e%9f%e5%88%9b%e8%8d%af%e7%89%a9%e5%a4%9a%e9%9d%b6%e7%82%b9%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/39606\/","title":{"rendered":"\u7cfb\u5217\u91cd\u78c5\u7efc\u8ff0\u89e3\u6790\u539f\u521b\u836f\u7269\u591a\u9776\u70b9\u4f5c\u7528"},"content":{"rendered":"
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\u8fd1\u65e5\uff0c\u6765\u81ea\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u836f\u7269\u7814\u7a76\u6240\u7684\u7814\u7a76\u56e2\u961f\u5148\u540e\u5728\u300aCNS & Neurological Disorders – Drug Targets\u300b\uff08IF\uff1a2.084\uff09\u3001\u300aPharmacological Research\u300b\uff08IF\uff1a4.897\uff09\u671f\u520a\u4e0a\u53d1\u8868\u4e86\u4e24\u7bc7\u5173\u4e8e\u4e01\u82ef\u915e\uff08NBP\uff09\u7684\u7efc\u8ff0\uff1a<\/p>\n


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Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke<\/em><\/span><\/p>\n

\u6982\u8ff0\u4e86\u4e01\u82ef\u915e\uff08NBP\uff09\u5728\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u6cbb\u7597\u4e2d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u4e34\u5e8a\u8bd5\u9a8c\u548c\u4f5c\u7528\u673a\u5236\uff1b<\/p>\n


<\/p>\n

From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives<\/em><\/span><\/p>\n

\u9996\u5148\u4eceNBP\u5bf9\u6025\u6027\u7f3a\u8840\u6027\u5352\u4e2d\u7684\u795e\u7ecf\u529f\u80fd\u6539\u5584\u4f5c\u7528\u5f00\u59cb\uff0c\u7136\u540e\u5c06\u5176\u5e94\u7528\u4e8e\u4e3b\u8981\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5e76\u5bf9\u5176\u4f5c\u7528\u673a\u7406\u8fdb\u884c\u4e86\u63a2\u8ba8\uff0c\u4ee5\u671f\u4e3a\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u63d0\u4f9b\u65b9\u5411\u3002<\/p>\n<\/section>\n<\/section>\n

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\"\u7cfb\u5217\u91cd\u78c5\u7efc\u8ff0\u89e3\u6790\u539f\u521b\u836f\u7269\u591a\u9776\u70b9\u4f5c\u7528\"<\/p>\n
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1<\/p>\n<\/section>\n<\/section>\n<\/section>\n

Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke\uff1a<\/em><\/span><\/p>\n


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\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u68c0\u7d22\u5927\u91cfNBP\u7684\u56fd\u5916\u6587\u732e\uff0c\u6700\u7ec8\u5f15\u7528\u4e86123\u7bc7\uff0c\u603b\u7ed3\u4e86\u8fd120\u5e74\u6765NBP\u6cbb\u7597\u7f3a\u8840\u6027\u5352\u4e2d\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u9610\u660e\u4e86\u4e3a\u4ec0\u4e48NBP\u662f\u4e00\u79cd\u6cbb\u7597\u7f3a\u8840\u6027\u5352\u4e2d\u7684\u5177\u6709\u4e34\u5e8a\u4ef7\u503c\u7684\u836f\u7269\u3002\u7814\u7a76\u6982\u8ff0\u4e86NBP\u5728\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u6cbb\u7597\u4e2d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u4e34\u5e8a\u8bd5\u9a8c\u548c\u4f5c\u7528\u673a\u5236\u3002NBP\u6539\u5584\u8111\u5faa\u73af\u548c\u795e\u7ecf\u529f\u80fd\u53ef\u80fd\u4f5c\u7528\u4e8e\u591a\u4e2a\u6d3b\u6027\u9776\u70b9\uff08\u4e0b\u56fe1\uff09\uff0c\u4e3b\u8981\u4f53\u73b0\u5728\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\uff1a1\u3001\u6539\u5584\u8111\u5fae\u5faa\u73af\uff1b2\u3001\u4fdd\u62a4\u8840\u8111\u5c4f\u969c\uff1b3\u3001\u6539\u5584\u7ebf\u7c92\u4f53\u529f\u80fd\uff1b4\u3001\u6291\u5236\u6c27\u5316\u5e94\u6fc0\uff1b5\u3001\u6291\u5236\u7ec6\u80de\u51cb\u4ea1\u548c\u81ea\u566c\uff1b6\u3001\u9632\u6b62\u708e\u75c7\uff1b7\u3001\u51cf\u5c11\u8c37\u6c28\u9178\u548c\u7ec6\u80de\u5185\u9499\u3002<\/p>\n


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\"\u7cfb\u5217\u91cd\u78c5\u7efc\u8ff0\u89e3\u6790\u539f\u521b\u836f\u7269\u591a\u9776\u70b9\u4f5c\u7528\"\u56fe1\uff1aNBP\u5728\u53ef\u80fd\u6d89\u53ca\u5352\u4e2d\u7684\u591a\u4e2a\u56e0\u7d20\u4e0a\u7684\u53ef\u80fd\u9776\u70b9<\/span><\/p>\n


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\u56fe1\u4e2d\uff0cNBP\u53ef\u901a\u8fc7\u5347\u9ad8NO\uff0cPGI2\uff0c\u964d\u4f4eTXA2\uff0c\u8212\u5f20\u8840\u7ba1\u6539\u5584rCBF\u3002 NBP\u8fd8\u53ef\u4ee5\u901a\u8fc7\u4e0a\u8c03VEGF\uff0cbFGF\uff0cTGF-\u03b21\u548c\u8840\u7ba1\u751f\u6210\u7684\u4f5c\u7528\u6539\u5584\u8111\u5faa\u73af\uff0c\u8fd9\u4e9b\u4f5c\u7528\u53ef\u4ee5\u53cd\u8fc7\u6765\u4fdd\u62a4BBB\u3002\u5728\u7f3a\u8840\u6027\u5352\u4e2d\u671f\u95f4\uff0c\u7ebf\u7c92\u4f53\u53d7\u635f\uff0cNBP\u53ef\u901a\u8fc7\u6539\u5584\u547c\u5438\u9176\u590d\u5408\u7269\u7684\u6d3b\u6027\uff0c\u4fdd\u62a4\u7ebf\u7c92\u4f53\u819c\u7684\u7ed3\u6784\u548c\u529f\u80fd\u4ee5\u53ca\u7ef4\u6301ATP\u9176\u6c34\u5e73\u6765\u6062\u590d\u7ebf\u7c92\u4f53\u529f\u80fd\u3002\u7f3a\u8840\u6027\u5352\u4e2d\u53ef\u901a\u8fc7\u589e\u52a0ROS\uff0cRNS\u548cMDA\u6c34\u5e73\u8bf1\u5bfc\u6c27\u5316\u5e94\u6fc0\uff0c\u540c\u65f6\u964d\u4f4eSOD\u548cNOS\u6d3b\u6027\uff0c\u5bfc\u81f4\u7ec6\u80de\u51cb\u4ea1\u548c\u708e\u75c7\u3002\u7136\u800c\uff0cNBP\u53ef\u901a\u8fc7\u964d\u4f4e\u6c27\u5316\u5e94\u6fc0\uff0c\u4e0a\u8c03\u6297\u51cb\u4ea1\u86cb\u767dBcl-2\uff0c\u4e0b\u8c03\u4fc3\u51cb\u4ea1\u86cb\u767dBax\uff0cBad\u548cBid\u8868\u8fbe\uff0c\u6291\u5236TNF-\u03b1\uff0cIL-1\u03b2\uff0cIL-6\u6c34\u5e73\u6765\u8c03\u8282\u8fd9\u4e9b\u8fc7\u7a0b\uff0c\u5e76\u4e14Nrf2\uff0cNF-\u03baB\uff0cJNK\u4e5f\u53ef\u80fd\u53c2\u4e0e\u8fd9\u4e9b\u5f71\u54cd\u3002\u6b64\u5916\uff0cNBP\u53ef\u4ee5\u51cf\u5c11\u8c37\u6c28\u9178\u548c\u7ec6\u80de\u5185\u9499\u7684\u91ca\u653e\u3002\uff08\u5411\u4e0a\u7bad\u5934\u8868\u793a\u589e\u5f3a\uff0c\u5411\u4e0b\u7bad\u5934\u8868\u793a\u6291\u5236\u3002 BBB\uff0c\u8840\u8111\u5c4f\u969c\uff1bROS\uff0c\u6d3b\u6027\u6c27; bFGF\uff0c\u78b1\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50; MMP\uff0c\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d; MMfu\uff0c\u7ebf\u7c92\u4f53\u819c\u6d41\u52a8\u6027; PLA2\uff0c\u78f7\u8102\u9176A2; TXA2\uff0c\u8840\u6813\u7d20A2; VEGF\uff0c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50; HGF\uff0c\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50; SOD\uff0c\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176;MDA\uff0c\u4e19\u4e8c\u919b\uff1bGSH\uff0c\u8c37\u80f1\u7518\u80bd; NO\uff0c\u4e00\u6c27\u5316\u6c2e; Nrf2\uff0c\u6838\u56e0\u5b50\u7ea2\u7ec6\u80de\u76f8\u5173\u56e0\u5b502; ARE\uff0c\u6297\u6c27\u5316\u53cd\u5e94\u5143\u7d20; TGF-\u03b21\uff0c\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b21\u3002\uff09<\/span><\/p>\n


<\/p>\n

\u7efc\u8ff0\u8868\u660e\uff1aNBP\u5df2\u88ab\u5e7f\u6cdb\u7528\u4e8e\u6cbb\u7597\u4e2d\u56fd\u6025\u6027\u7f3a\u8840\u6027\u8111\u5352\u4e2d\uff0c\u4e34\u5e8a\u7597\u6548\u826f\u597d\u3002\u6b64\u5916\uff0cNBP\u8f6f\u80f6\u56ca\u5728\u7f3a\u8840\u6027\u5352\u4e2d\u60a3\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u4e8e2017\u5e74\u5728\u7f8e\u56fd\u542f\u52a8\uff0c\u76ee\u7684\u662f\u8bc4\u4f30NBP\u6cbb\u7597\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u6025\u6027\u7f3a\u8840\u6027\u5352\u4e2d\u60a3\u8005\u7684\u5b89\u5168\u6027\u3002<\/p>\n


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\n
\"\u7cfb\u5217\u91cd\u78c5\u7efc\u8ff0\u89e3\u6790\u539f\u521b\u836f\u7269\u591a\u9776\u70b9\u4f5c\u7528\"<\/p>\n
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2<\/p>\n<\/section>\n<\/section>\n<\/section>\n

From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives<\/em>\uff1a<\/span><\/span><\/p>\n


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\u7814\u7a76\u8005\u5f15\u7528\u4e86152\u7bc7\u6587\u732e\uff0c\u63d0\u5230NBP\u9664\u4e86\u5728\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u7684\u5f3a\u6548\u836f\u7406\u4f5c\u7528\u5916\uff0c\u8fd8\u5728\u591a\u79cd\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u8868\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\uff0c\u8840\u7ba1\u6027\u75f4\u5446\uff08VaD\uff09\uff0c\u5e15\u91d1\u68ee\u75c5(PD)\u548c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u3002\u800c\u6f5c\u5728\u673a\u5236\u9664\u4e86\u7b2c\u4e00\u7bc7\u7efc\u8ff0\u6240\u63d0\u53ca\u7684\u51cf\u8f7b\u6c27\u5316\u5e94\u6fc0\uff0c\u4fdd\u62a4\u7ebf\u7c92\u4f53\u529f\u80fd\uff0c\u51cf\u5c11\u795e\u7ecf\u7ec6\u80de\u51cb\u4ea1\uff0c\u51cf\u5f31\u708e\u75c7\u53cd\u5e94\uff0c\u4ecb\u5bfc\u795e\u7ecf\u5143\u81ea\u566c\u548c\u589e\u5f3a\u795e\u7ecf\u53d1\u751f\u4e4b\u5916\uff0c\u67d0\u4e9b\u4fe1\u53f7\u901a\u8def\uff0c\u5305\u62ecp38\u548cJNK MAPK\u4fe1\u53f7\u901a\u8def\uff0cWnt \/\u03b2-catenin\u4fe1\u53f7\u901a\u8def\uff0cPI3K \/ Akt\u4fe1\u53f7\u901a\u8def\uff0cNF-\u03baB\u4fe1\u53f7\u901a\u8def\u548c\u6838\u56e0\u5b50\uff08\u7ea2\u7ec6\u80de\u884d\u751f2\uff09\u68372\uff08NrF-2\uff09\u4fe1\u53f7\u901a\u8def\u4e5f\u88ab\u591a\u6b21\u62a5\u9053\u3002\u8fd9\u4e9b\u7814\u7a76\u7efc\u5408\u8868\u660eNBPs\uff08\u4e01\u82ef\u915e\u53ca\u5176\u884d\u751f\u7269\uff09\u5177\u6709\u5e7f\u6cdb\u7684\u836f\u7406\u6d3b\u6027\uff0c\u4e3a\u6cbb\u7597\u8fd9\u4e9b\u76ee\u524d\u65e0\u6cd5\u6cbb\u6108\u7684\u75be\u75c5\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002<\/span>
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\u7814\u7a76\u8005\u9996\u5148\u6982\u62ec\u4e86NBP\u53ca\u5176\u884d\u751f\u7269\u7684\u73b0\u6709\u7814\u7a76\uff0c\u4e3b\u8981\u4ecb\u7ecd\u4e86Dl-NBP\u548cl-NBP\u30012-\uff081-\u7f9f\u57fa\u620a\u57fa\uff09-\u82ef\u7532\u9178\u94be\u3001NBP\u7684\u5355\u53d6\u4ee3\u82ef\u884d\u751f\u7269\u3001NBP\u7684\u6c14\u4f53\u9012\u8d28-\u4f9b\u4f53\u884d\u751f\u7269\u3001NBP\u7684\u53cc\u836f\u884d\u751f\u7269\u8fd9\u4e94\u79cdNBP\u53ca\u5176\u884d\u751f\u7269\u7684\u5927\u81f4\u7814\u7a76\u5386\u7a0b\u3001\u4f5c\u7528\u673a\u5236\u53ca\u5176\u836f\u7406\u4f5c\u7528\u3002<\/p>\n


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\u5176\u6b21\uff0c\u6587\u7ae0\u4ecb\u7ecd\u4e86NBPs\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u591a\u9776\u70b9\u6cbb\u7597\u6548\u679c\u4ee5\u53ca\u5bf9\u5176\u4ed6\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n


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\"\u7cfb\u5217\u91cd\u78c5\u7efc\u8ff0\u89e3\u6790\u539f\u521b\u836f\u7269\u591a\u9776\u70b9\u4f5c\u7528\"<\/p>\n

\u56fe2\uff1aNBPs\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u591a\u9776\u70b9\u6cbb\u7597\u6548\u679c<\/span><\/p>\n


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\u56fe2\u4e2d\u663e\u793a\u4e86NBPs\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u591a\u9776\u70b9\u6cbb\u7597\u6548\u679c\uff0c\u5305\u62ec\u4ecb\u5bfcAPP\u52a0\u5de5\uff0c\u6291\u5236tau\u86cb\u767d\u8fc7\u5ea6\u78f7\u9178\u5316\uff0c\u6539\u5584\u7a81\u89e6\u7f3a\u5931\u548c\u589e\u5f3a\u7a81\u89e6\u53ef\u5851\u6027\u3002 \u67d0\u4e9b\u86cb\u767d\u8d28\u9776\u6807\u5305\u62ecADAM10\uff0cADAM17\uff0cCDK-5\uff0cGSK-3\u03b2\u548cBDNF\u88ab\u8ba4\u4e3a\u662f\u9ad8\u5ea6\u53c2\u4e0e\u7684\u3002 \u201c\u2191\u201d\u8868\u793a\u4fc3\u8fdb\u6548\u679c\uff0c\u201c\u2193\u201d\u8868\u793a\u6291\u5236\u6548\u679c\u3002 \uff08\u56fe\u7247\u662f\u6839\u636eRoskoski\u7684\u6307\u5357\u51c6\u5907\u7684\uff09<\/p>\n


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\"\u7cfb\u5217\u91cd\u78c5\u7efc\u8ff0\u89e3\u6790\u539f\u521b\u836f\u7269\u591a\u9776\u70b9\u4f5c\u7528\"<\/p>\n

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\"\u7cfb\u5217\u91cd\u78c5\u7efc\u8ff0\u89e3\u6790\u539f\u521b\u836f\u7269\u591a\u9776\u70b9\u4f5c\u7528\"<\/section>\n
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\u7f16\u8f91 | \u674e\u5b9d\u8587<\/span>
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[1] Shan Wang,Ying Peng,et al. Dl-3-n-Butylphthalide(NBP): A Promising Therapeutic Agent for Ischemic Stroke.[J]. CNS &Neurological Disorders – Drug Targets,2018, 17, 338-347<\/span><\/p>\n

[2] Longjian Huang, Ying Peng, et al. From stroke toneurodegenerative diseases: The multi-target neuroprotective effects of3-n-butylphthalide and its derivatives.[J]. Pharmacological Research,135(2018)201-211<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

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