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style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537166464.png\" alt=\"\u5168\u7403\u65b0\u4e2d\u56fd\u7387\u5148\u4e0a\u5e02\u7f57\u6c99\u53f8\u4ed6\uff0c\u5f00\u542f\u80be\u6027\u8d2b\u8840\u7684\u65b0\u6cbb\u7597\u65f6\u4ee3\uff01\" title=\"\u5168\u7403\u65b0\u4e2d\u56fd\u7387\u5148\u4e0a\u5e02\u7f57\u6c99\u53f8\u4ed6\uff0c\u5f00\u542f\u80be\u6027\u8d2b\u8840\u7684\u65b0\u6cbb\u7597\u65f6\u4ee3\uff01\"  \/><\/p>\n<p style=\"margin-bottom: 8px;text-align: center;line-height: 24px;background: white;\"><span style=\"font-size: 14px;\">\u6570\u636e\u6765\u6e90\uff1a\u4e2d\u56fd\u533b\u836f\u5de5\u4e1a\u4fe1\u606f\u4e2d\u5fc3 \u836f\u7269\u7efc\u5408\u6570\u636e\u5e93PDB<\/span><\/p>\n<p style=\"margin-bottom: 8px;text-align: center;line-height: 24px;background: white;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"margin-bottom: 8px;text-align: left;line-height: 24px;background: white;\"><strong style=\"font-size: 15px;text-align: justify;\">&nbsp; \u56fd\u5185\u957f\u6548EPO\u53ca\u65b0\u578b\u80be\u6027\u8d2b\u8840\u6cbb\u7597\u836f\u7269\u7684\u5e03\u5c40\u5c06\u7ed9\u60a3\u8005\u5e26\u6765\u5168\u65b0\u6cbb\u7597\u6548\u679c<\/strong><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4e0e\u80f0\u5c9b\u7d20\u3001GLP-1\u4e00\u6837\uff0cEPO\u8ffd\u6c42\u7684\u4e5f\u662f\u957f\u6548\u4ee5\u51cf\u5c11\u6ce8\u5c04\u6b21\u6570\uff0c\u63d0\u9ad8\u60a3\u8005\u7684\u987a\u5e94\u6027\uff0c\u56e0\u6b64\u957f\u6548EPO\u662f\u8fc5\u901f\u5360\u9886\u5e02\u573a\u7684\u5173\u952e\u3002\u6839\u636e\u4e2d\u56fd\u533b\u836f\u5de5\u4e1a\u4fe1\u606f\u4e2d\u5fc3\u4e2d\u56fd\u65b0\u836f\u7814\u53d1\u76d1\u6d4b\u6570\u636e\u5e93 CPM \u76d1\u6d4b\uff0c\u7f57\u6c0f\u7533\u62a5\u4e0a\u5e02\u7684\u7532\u6c27\u805a\u4e8c\u9187\u91cd\u7ec4\u4eba\u4fc3\u7ea2\u7d20\u6ce8\u5c04\u6db2\u3001\u6c88\u9633\u4e09\u751f\u5236\u836f\u7533\u62a5\u4e34\u5e8a\u7684\u805a\u4e59\u4e8c\u9187\u91cd\u7ec4\u4eba\u4fc3\u7ea2\u7d20\u6ce8\u5c04\u6db2\u3001\u82cf\u5dde\u665f\u6d4e\u836f\u4e1a\u7533\u62a5\u4e34\u5e8a\u7684\u957f\u6548\u4eba\u7ea2\u7ec6\u80de\u751f\u957f\u523a\u6fc0\u7d20\u6ce8\u5c04\u6db2\u5747\u5df2\u5904\u4e8eCPDA\u5df2\u53d1\u4ef6\u72b6\u6001\uff0c\u53e6\u5916\u8fd8\u6709\u6df1\u5733\u8d5b\u4fdd\u5c14\u751f\u7269\u836f\u4e1a\u3001\u5c71\u4e1c\u963f\u534e\u751f\u7269\u836f\u4e1a\u6709\u9650\u516c\u53f8\u548c\u4e0a\u6d77\u51ef\u8302\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\u4e5f\u5df2\u8fdb\u884c\u4e86\u91cd\u7ec4\u4eba\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\u7684\u4e34\u5e8a\u7533\u8bf7\u3002\u968f\u7740\u957f\u6548EPO\u4ea7\u54c1\u7684\u7814\u53d1\u548c\u4e0a\u5e02\u8fdb\u7a0b\uff0c\u6709\u52a9\u4e8e\u62d3\u5c55\u56fd\u5185EPO\u4ea7\u54c1\u5e02\u573a\uff0c\u5f25\u8865\u957f\u6548EPO\u4ea7\u54c1\u5728\u4e2d\u56fd\u5e02\u573a\u7684\u7a7a\u767d\uff0c\u4ece\u800c\u6709\u6548\u670d\u52a1\u76f8\u5173\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"margin-bottom:8px;text-align:center;line-height:24px;background:white;\"><span style=\"font-size: 15px;\">\u88683.\u76ee\u524d\u91cd\u7ec4\u4eba\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\u56fd\u5185\u7533\u62a5\u4e3b\u8981\u60c5\u51b5<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\"><\/span><strong><span style=\"font-size:15px;font-family:\u5fae\u8f6f\u96c5\u9ed1,sans-serif;color:#333333;\">\u7533\u62a5\u4e0a\u5e02\u60c5\u51b5<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537166464-1.png\" alt=\"\u5168\u7403\u65b0\u4e2d\u56fd\u7387\u5148\u4e0a\u5e02\u7f57\u6c99\u53f8\u4ed6\uff0c\u5f00\u542f\u80be\u6027\u8d2b\u8840\u7684\u65b0\u6cbb\u7597\u65f6\u4ee3\uff01\" title=\"\u5168\u7403\u65b0\u4e2d\u56fd\u7387\u5148\u4e0a\u5e02\u7f57\u6c99\u53f8\u4ed6\uff0c\u5f00\u542f\u80be\u6027\u8d2b\u8840\u7684\u65b0\u6cbb\u7597\u65f6\u4ee3\uff01\"  \/><\/p>\n<p style=\"margin-bottom:8px;text-align:left;line-height:24px;background:white;\"><strong><span style=\"font-size:15px;font-family:\u5fae\u8f6f\u96c5\u9ed1,sans-serif;color:#333333;\">&nbsp; \u7533\u62a5\u4e34\u5e8a\u60c5\u51b5<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537166465.png\" alt=\"\u5168\u7403\u65b0\u4e2d\u56fd\u7387\u5148\u4e0a\u5e02\u7f57\u6c99\u53f8\u4ed6\uff0c\u5f00\u542f\u80be\u6027\u8d2b\u8840\u7684\u65b0\u6cbb\u7597\u65f6\u4ee3\uff01\" title=\"\u5168\u7403\u65b0\u4e2d\u56fd\u7387\u5148\u4e0a\u5e02\u7f57\u6c99\u53f8\u4ed6\uff0c\u5f00\u542f\u80be\u6027\u8d2b\u8840\u7684\u65b0\u6cbb\u7597\u65f6\u4ee3\uff01\"  \/><\/p>\n<p style=\"margin-bottom: 8px;text-align: center;line-height: 24px;background: white;\"><span style=\"font-size: 14px;\">\u6570\u636e\u6765\u6e90\uff1a\u4e2d\u56fd\u533b\u836f\u5de5\u4e1a\u4fe1\u606f\u4e2d\u5fc3 \u4e2d\u56fd\u65b0\u836f\u7814\u53d1\u76d1\u6d4b\u6570\u636e\u5e93CPM<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u76ee\u524d\u7684\u80be\u6027\u8d2b\u8840\u4e3b\u8981\u662f\u7ea2\u8840\u7403\u751f\u6210\u523a\u6fc0\u56e0\u5b50\uff08erythropoiesis stimulating agents, ESAs\uff09\u7597\u6cd5\uff0c\u867d\u7136\u6574\u4f53\u770b\u6765\uff0cESAs\u8fd8\u662f\u4e00\u4e2a\u975e\u5e38\u5b89\u5168\u7684\u7597\u6cd5\uff0c\u4f46\u662f\u540e\u7eed\u53d1\u73b0\u6cbb\u7597\u5bfc\u81f4\u9ad8\u5fc3\u8840\u7ba1\u75be\u75c5\u53d1\u751f\u7387\uff0c \u751a\u81f3\u7531\u6b64\u5f15\u53d1\u6b7b\u4ea1\u3002\u901a\u8fc7\u8c03\u63a7\u4f53\u5185HIF \uff08\u5168\u79f0\u662fHypoxia inducible factor\uff0c\u4e2d\u6587\u4e3a\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff09 \u7684\u8868\u8fbe\u6765\u63a7\u5236EPO\u7684\u542b\u91cf\uff0c\u4ece\u800c\u63d0\u9ad8\u8840\u6db2\u4e2d\u8840\u7ea2\u86cb\u767d\u7684\u5f62\u6210\u3001\u63d0\u9ad8\u4f53\u5185\u8840\u7ec6\u80de\u7684\u542b\u91cf\u3002HIF\u4e3b\u8981\u662f\u7531\u03b1\u4e9a\u57fa\u548c\u03b2\u4e9a\u57fa\u7ec4\u6210\u5177\u6709\u8f6c\u5f55\u6d3b\u6027\u7684\u5f02\u6e90\u4e8c\u805a\u4f53\uff0c\u5176\u4e2d\u03b1\u4e9a\u57fa\u4e25\u683c\u53d7\u5230\u6c27\u6c14\u6d53\u5ea6\u7684\u8c03\u63a7\uff0c\u800c\u03b2\u4e9a\u57fa\u5219\u662f\u6301\u7eed\u5f97\u8868\u8fbe\uff0c\u56e0\u6b64\u5bf9HIF\u7684\u7814\u7a76\u4e3b\u8981\u662f\u9488\u5bf9\u03b1\u4e9a\u57fa\u8fdb\u884c\u7684\u3002HIF-1\u03b1\u548cHIF-2\u03b1\u7684\u534a\u8870\u671f\u90fd\u975e\u5e38\u77ed\uff0c\u5728\u7ec6\u80de\u4e2d\u5904\u4e8e\u4e0d\u65ad\u5408\u6210\u548c\u964d\u89e3\u7684\u8fc7\u7a0b\u3002\u8fd9\u4e2a\u964d\u89e3\u8fc7\u7a0b\u91cd\u8981\u662f\u901a\u8fc7\u812f\u6c28\u9178\u7f9f\u5316\u9176\u533a\u57df\uff08PHD) \u5728\u6c27\u5206\u5b50\u7684\u53c2\u4e0e\u4e0b\u4f7fHIF\u03b1\u7f9f\u57fa\u5316\uff0c\u4f7fHIF\u03b1\u80fd\u591f\u88abVHLE3\u6cdb\u7d20\u8fde\u63a5\u9176\u8fa8\u8bc6\u5e76\u6cdb\u7d20\u5316\uff0c \u4e4b\u540e\u900f\u8fc7\u86cb\u767d\u9176\u4f53\u4f7f\u5176\u88ab\u5feb\u901f\u964d\u89e3\u3002\u8fd9\u91cc\u7684PHD\uff0c\u6709\u7684\u65f6\u5019\u4e5f\u88ab\u79f0\u4e3aHIF-PH\uff0c\u5373HIF\u812f\u6c28\u9170\u7f9f\u5316\u9176\u3002\u6211\u56fd\u5df2\u7ecf\u521b\u65b0\u751f\u4ea7\u51fa\u6cbb\u7597\u80be\u6027\u8d2b\u8840\u7684\u53e3\u670d\u836f\uff0c\u5e76\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\uff0c \u4e0d\u8fdc\u7684\u5c06\u6765\u80be\u53cb\u4eec\u4e0d\u7528\u518d\u6ce8\u5c04\u4fc3\u7ea2\u7d20\uff0c\u4e5f\u4e0d\u7528\u53e6\u5916\u8865\u5145\u94c1\u5242\uff0c\u7ed9\u5e7f\u5927\u80be\u75c5\u60a3\u8005\u5e26\u6765\u771f\u6b63\u5b9e\u60e0\u3002<\/span><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u73b0\u5728\u4e3b\u8981\u6709\u56db\u5bb6\u516c\u53f8\u5728\u8fdb\u884cPHD\u6291\u5236\u5242\u7684\u5f00\u53d1\uff0c \u5206\u522b\u6709Fibrogen\u7684\u7f57\u6c99\u53f8\u4ed6\uff08roxadustat\uff09\u3001Akebia\u7684vadadustat\u3001GSK\u7684Daprodustat\u4ee5\u53caBayer\u7684molidustat\u3002\u5176\u4e2d\uff0c\u9664Akebia\u7684vadadustat\u5916\uff0c\u5176\u4ed6\u5747\u5df2\u8fdb\u884c\u4e86\u56fd\u5185\u4e34\u5e8a\u7533\u8bf7\uff1b\u5176\u4e2d\uff0c\u7f8e\u56fd\u751f\u7269\u5236\u836f\u516c\u53f8Fibrogen\u7684\u7f57\u6c99\u53f8\u4ed6\u57282017\u5e74\u5e74\u5e95\uff0c\u88ab\u56fd\u5bb6\u836f\u54c1\u8bc4\u5ba1\u4e2d\u5fc3\uff08CFDE\uff09\u4ee5\u201c\u4e0e\u73b0\u6709\u6cbb\u7597\u624b\u6bb5\u76f8\u6bd4\u5177\u6709\u660e\u663e\u6cbb\u7597\u4f18\u52bf\u201d\u7684\u65b0\u836f\u88ab\u5217\u4e3a\u4f18\u5148\u5ba1\u8bc4\u836f\u7269\uff0c\u9884\u671f\u57282018\u5e74\u7b2c3\u5b63\u5ea6\u524d\u540e\u4e0a\u5e02\u3002<\/span><\/p>\n<p style=\"margin-bottom:8px;text-align:center;line-height:24px;background:white;\"><span style=\"font-size: 15px;\">\u88684.\u7f57\u6c99\u53f8\u4ed6\u56fd\u5185\u7533\u62a5\u4e0a\u5e02\u5ba1\u8bc4\u5ba1\u8bc4\u8fdb\u5ea6<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537166465.jpg\" alt=\"\u5168\u7403\u65b0\u4e2d\u56fd\u7387\u5148\u4e0a\u5e02\u7f57\u6c99\u53f8\u4ed6\uff0c\u5f00\u542f\u80be\u6027\u8d2b\u8840\u7684\u65b0\u6cbb\u7597\u65f6\u4ee3\uff01\" title=\"\u5168\u7403\u65b0\u4e2d\u56fd\u7387\u5148\u4e0a\u5e02\u7f57\u6c99\u53f8\u4ed6\uff0c\u5f00\u542f\u80be\u6027\u8d2b\u8840\u7684\u65b0\u6cbb\u7597\u65f6\u4ee3\uff01\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;font-size: 14px;line-height: 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