{"id":40598,"date":"2018-09-01T01:00:00","date_gmt":"2018-09-17T06:43:56","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e3%80%90%e5%a3%b9%e5%91%a8%e8%8d%af%e8%ae%af%e3%80%91%e5%9b%bd%e5%8a%a1%e9%99%a2%e5%ae%89%e6%8e%92%e4%ba%8650%e4%bb%b6%e5%8c%bb%e8%8d%af%e5%a4%a7%e4%ba%8b%ef%bc%81602%e4%b8%aa%e8%bf%9b%e5%8f%a3\/"},"modified":"2018-09-17T14:43:57","modified_gmt":"2018-09-17T06:43:57","slug":"%e3%80%90%e5%a3%b9%e5%91%a8%e8%8d%af%e8%ae%af%e3%80%91%e5%9b%bd%e5%8a%a1%e9%99%a2%e5%ae%89%e6%8e%92%e4%ba%8650%e4%bb%b6%e5%8c%bb%e8%8d%af%e5%a4%a7%e4%ba%8b%ef%bc%81602%e4%b8%aa%e8%bf%9b%e5%8f%a3","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/40598\/","title":{"rendered":"\u3010\u58f9\u5468\u836f\u8baf\u3011\u56fd\u52a1\u9662\u5b89\u6392\u4e8650\u4ef6\u533b\u836f\u5927\u4e8b\uff01602\u4e2a\u8fdb\u53e3\u836f\u53ca\u6297\u764c\u836f\u8981\u964d\u4ef7 \u6700\u9ad8\u964d\u5e45\u8fbe60%\uff01"},"content":{"rendered":"
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\u672c\u5468\u89c6\u70b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fd\u52a1\u9662\u5b89\u6392\u4e8650\u4ef6\u533b\u836f\u5927\u4e8b<\/strong><\/span><\/p>\n

\u4e0b\u534a\u5e74\u533b\u6539\u91cd\u70b9\u4efb\u52a1\u6765\u4e86\uff0c\u4e00\u517150\u9879\u3002\u6309\u75c5\u79cd\u4ed8\u8d39\u5168\u56fd\u63a8\u5e7f\u3001\u57fa\u836f\u76ee\u5f55\u5373\u5c06\u8c03\u6574\u3001\u836f\u54c1\u96c6\u91c7\u4ef7\u683c\u53c8\u8981\u964d\u4e86\u2026\u20268\u670828\u65e5\uff0c\u4e2d\u56fd\u653f\u5e9c\u7f51\u53d1\u5e03\u300a\u6df1\u5316\u533b\u836f\u536b\u751f\u4f53\u5236\u6539\u97692018\u5e74\u4e0b\u534a\u5e74\u91cd\u70b9\u5de5\u4f5c\u4efb\u52a1\u300b\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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1.<\/strong><\/span>\u68c0\u67e5\u672a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u836f\u54c1 \u5728\u8fd9\u4e00\u7701\u6682\u65f6\u5b89\u5168<\/strong><\/span><\/p>\n

8\u670829\u65e5\uff0c\u56db\u5ddd\u7701\u4eba\u6c11\u653f\u5e9c\u529e\u516c\u5385\u5173\u4e8e\u6539\u9769\u5b8c\u5584\u4eff\u5236\u836f\u4f9b\u5e94\u4fdd\u969c\u53ca\u4f7f\u7528\u653f\u7b56\u7684\u5b9e\u65bd\u610f\u89c1\uff08\u5f81\u6c42\u610f\u89c1\u7a3f\uff09\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span>
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2.<\/strong><\/span>602\u4e2a\u8fdb\u53e3\u836f\u53ca\u6297\u764c\u836f\u8981\u964d\u4ef7 \u6700\u9ad8\u964d\u5e45\u8fbe60%<\/strong><\/span>
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8\u670829\u65e5\uff0c\u6d77\u5357\u7701\u516c\u5171\u8d44\u6e90\u4ea4\u6613\u4e2d\u5fc3\u53d1\u5e03\u7684\u300a\u5173\u4e8e\u6267\u884c\u8fdb\u53e3\u836f\u53ca\u6297\u764c\u836f\u964d\u4ef7\u5de5\u4f5c\u7684\u901a\u77e5\uff08\u7b2c\u4e8c\u6279\uff09\u300b\u663e\u793a\uff0c\u5bf9\u8f89\u745e\u5236\u836f\u6709\u9650\u516c\u53f8\u7b49\u4f01\u4e1a\u63d0\u4ea4\u7684583\u4e2a\u8fdb\u53e3\u836f\u53ca\u6297\u764c\u836f\u964d\u4ef7\u7533\u8bf7\u8fdb\u884c\u516c\u793a\u3002\u516c\u793a\u671f\u6ee1\u540e\uff0c\u5c06\u5bf9\u8be5\u7701\u533b\u836f\u96c6\u4e2d\u91c7\u8d2d\u670d\u52a1\u5e73\u53f0\u8fdb\u884c\u4ef7\u683c\u8c03\u6574\u30028\u670828\u65e5\uff0c\u8be5\u5e73\u53f0\u8fd8\u53d1\u5e03\u4e86\u5bf9\u56fd\u5bb6\u533b\u4fdd\u5c40\u901a\u77e5\u4e2d\u6d89\u53ca\u768419\u4e2a\u524d\u671f\u56fd\u5bb6\u8c08\u5224\u6297\u764c\u836f\u54c1\u5728\u6211\u7701\u533b\u836f\u96c6\u4e2d\u91c7\u8d2d\u670d\u52a1\u5e73\u53f0\u4e0a\u8fdb\u884c\u4ef7\u683c\u8c03\u6574\u3002\u4e24\u8005\u76f8\u52a0\uff0c\u964d\u4ef7\u836f\u54c1\u603b\u91cf\u8fbe\u5230602\u4e2a\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n

3.<\/strong><\/span>\u56fd\u52a1\u9662\u4f1a\u8bae\u5ba3\u5e03\uff1a\u57fa\u836f\u76ee\u5f55\u589e\u81f3685\u79cd<\/strong><\/span><\/p>\n

\u636e8\u670830\u65e5\u592e\u89c6\u65b0\u95fb\u8054\u64ad\u6700\u65b0\u62a5\u9053\uff0c\u56fd\u52a1\u9662\u603b\u7406\u4e3b\u6301\u53ec\u5f00\u56fd\u52a1\u9662\u5e38\u52a1\u4f1a\u8bae\uff0c\u542c\u53d6\u4eca\u5e74\u51cf\u7a0e\u964d\u8d39\u653f\u7b56\u63aa\u65bd\u843d\u5b9e\u60c5\u51b5\u6c47\u62a5\uff0c\u51b3\u5b9a\u518d\u63a8\u65b0\u4e3e\u63aa\u652f\u6301\u5b9e\u4f53\u7ecf\u6d4e\u53d1\u5c55\uff1b\u90e8\u7f72\u5b8c\u5584\u56fd\u5bb6\u57fa\u672c\u836f\u7269\u5236\u5ea6\uff0c\u4fdd\u969c\u7fa4\u4f17\u57fa\u672c\u7528\u836f\u9700\u6c42\u3001\u51cf\u8f7b\u836f\u8d39\u8d1f\u62c5\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n

4.<\/strong><\/span>\u56db\u90e8\u59d4\u8054\u624b \u5927\u6279\u836f\u5e97\u4e0d\u80fd\u5356\u5904\u65b9\u836f\uff01<\/strong><\/span><\/p>\n

8\u670828\u65e5\uff0c\u300a\u56fd\u52a1\u9662\u529e\u516c\u5385\u5173\u4e8e\u5370\u53d1\u6df1\u5316\u533b\u836f\u536b\u751f\u4f53\u5236\u6539\u97692018\u5e74\u4e0b\u534a\u5e74\u91cd\u70b9\u5de5\u4f5c\u4efb\u52a1\u7684\u901a\u77e5\uff08\u56fd\u529e\u53d1\u30142018\u301583\u53f7\uff09\u300b\uff08\u4ee5\u4e0b\u7b80\u79f0\u300a\u901a\u77e5\u300b\uff09\u6b63\u5f0f\u6302\u7f51\u3002\u300a\u901a\u77e5\u300b\u63d0\u51fa\uff0c\u5236\u5b9a\u96f6\u552e\u836f\u5e97\u5206\u7c7b\u5206\u7ea7\u7ba1\u7406\u7684\u6307\u5bfc\u6027\u6587\u4ef6\uff0c\u652f\u6301\u96f6\u552e\u836f\u5e97\u8fde\u9501\u53d1\u5c55\uff0c\u5141\u8bb8\u95e8\u8bca\u60a3\u8005\u81ea\u4e3b\u9009\u62e9\u5728\u533b\u7597\u673a\u6784\u6216\u96f6\u552e\u836f\u5e97\u8d2d\u836f\uff0c\u5e76\u7531\u5546\u52a1\u90e8\u3001\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u3001\u56fd\u5bb6\u533b\u4fdd\u5c40\u3001\u56fd\u5bb6\u836f\u76d1\u5c40\u56db\u90e8\u59d4\u8054\u624b\u8d1f\u8d23\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f01\u4e1a\u52a8\u6001<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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1.<\/span><\/strong><\/span>\u65d7\u4e0b\u516c\u53f8\u88ab\u516c\u5f00\u4e3e\u62a5 \u590d\u661f\u533b\u836fA\u80a1H\u80a1\u9f50\u8df3\u6c34<\/span><\/strong><\/span><\/p>\n

\u8fd1\u65e5\uff0c\u91cd\u5e86\u98df\u836f\u76d1\u5c40\u5b98\u7f51\u7684\u4e00\u5219\u516c\u5f00\u4e3e\u62a5\u79f0\uff0c\u590d\u661f\u533b\u836f\u65d7\u4e0b\u91cd\u5e86\u533b\u836f\u5de5\u4e1a\u7814\u7a76\u9662\u6709\u9650\u8d23\u4efb\u516c\u53f8\uff08\u7b80\u79f0\u201c\u91cd\u5e86\u533b\u5de5\u9662\u201d\uff09\u751f\u4ea7\u8d28\u91cf\u7ba1\u7406\u5341\u5206\u6df7\u4e71\uff0c\u9886\u5bfc\u65e0\u89c6\u836f\u54c1\u751f\u4ea7\u7ba1\u7406\u6cd5\u89c4\uff0c\u5e26\u5934\u5f04\u865a\u4f5c\u5047\uff1b\u91cd\u5e86\u533b\u5de5\u9662\u5236\u836f\u516c\u53f8\u751f\u4ea7\u7684\u4e3b\u8981\u4ea7\u54c1\uff08\u539f\u6599\u836f\uff09\u51e0\u4e4e\u6240\u6709\u7684\u751f\u4ea7\u5de5\u827a\u90fd\u6ca1\u6709\u6839\u636e\u6807\u51c6\u7684\u5de5\u827a\u751f\u4ea7\uff0c\u5927\u91cf\u7f16\u9020\u751f\u4ea7\u8bb0\u5f55\u3001\u68c0\u67e5\u8bb0\u5f55\uff1b\u9a97\u53d6\u4e0a\u7ea7\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\uff0c\u9a97\u53d6\u836f\u54c1GMP\u8bc1\u4e66\u3002\u7531\u4e8e\u5b9e\u9645\u751f\u4ea7\u5de5\u827a\u4e0e\u6279\u51c6\u5de5\u827a\u4e0d\u4e00\u81f4\uff0c\u5728\u5411\u91cd\u5e86\u5e02\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7533\u8bf7\u573a\u5730\u8f6c\u79fb\u548cGMP\u8bc1\u4e66\u8fc7\u7a0b\u4e2d\uff0c\u7528\u8001\u5de5\u827a\u7f16\u9020\u6210\u5957\u7684\u751f\u4ea7\u548c\u68c0\u9a8c\u8bb0\u5f55\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span>
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2<\/span><\/strong><\/span>.<\/span><\/strong><\/span>BMS\u65b0\u4e00\u4ee3\u916a\u6c28\u9178\u9176\u6291\u5236\u5242\u5e74\u5e95\u6709\u671b\u518d\u6dfb\u65b0\u9002\u5e94\u75c7<\/span><\/strong><\/span>
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\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u5ba3\u5e03FDA\u63a5\u53d7\u4e86\u8be5\u516c\u53f8\u4e3aSprycel\uff08dasatinib\uff0c\u8fbe\u6c99\u66ff\u5c3c\uff09\u9012\u4ea4\u7684\u8865\u5145\u4e0a\u5e02\u7533\u8bf7\u3002\u5b83\u5c06\u4e0e\u5316\u7597\u8054\u7528\uff0c\u7528\u4e8e\u6cbb\u7597\u65b0\u786e\u8bca\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\uff08Ph+\uff09\u7684\u6025\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\uff08ALL\uff09\u513f\u7ae5\u60a3\u8005\u3002FDA\u6709\u671b\u57282018\u5e7412\u670829\u65e5\u4e4b\u524d\u505a\u51fa\u56de\u590d\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n

3.<\/span><\/strong><\/span>Nebula\u5b8c\u6210430\u4e07\u7f8e\u5143\u79cd\u5b50\u8f6e\u878d\u8d44 \u5f00\u521b\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u65f6\u4ee3<\/span><\/strong><\/span><\/p>\n

8\u670829\u65e5\uff0cNebula Genomics\u5ba3\u5e03\uff0c\u83b7\u5f97430\u4e07\u7f8e\u5143\u7684\u79cd\u5b50\u8f6e\u878d\u8d44\u3002\u516c\u53f8\u5c06\u5229\u7528\u8fd9\u4e9b\u8d44\u91d1\u4e3a\u57fa\u56e0\u7ec4\u6570\u636e\u521b\u5efa\u4e00\u4e2a\u53ef\u9760\u3001\u5b89\u5168\u4e14\u5206\u6563\u7684\u5e02\u573a\u4ee5\u5f00\u521b\u4e2a\u4eba\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u65f6\u4ee3\u3002\u516c\u53f8\u8fd8\u5c06\u4e0e\u9886\u5148\u7684\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u548c\u6574\u5408\u516c\u53f8Veritas Genetics\u5efa\u7acb\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\uff0c\u8be5\u5408\u4f5c\u5c06\u4fc3\u4f7fNebula\u7684\u5e02\u573a\u4e0eVeritas\u7684Arvados\u516c\u5f00\u4ee3\u7801\u8f6f\u4ef6\u5e73\u53f0\u8fde\u63a5\u8d77\u6765\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n

4.<\/span><\/strong><\/span>\u534e\u4e1c\u533b\u836f15\u4ebf\u6536\u8d2d\u82f1\u56fdSinclair \u8fdb\u51655000\u4ebf\u533b\u7f8e\u6218\u573a<\/span><\/strong><\/span>
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8\u670829\u65e5\uff0c\u534e\u4e1c\u533b\u836f\u5ba3\u5e03\u62df\u4ee5\u73b0\u91d1\u8981\u7ea6\u65b9\u5f0f\u6536\u8d2d\u82f1\u56fdSinclair Pharma plc\u5168\u90e8\u80a1\u4efd\uff0c\u4e14\u5df2\u4e8e\u4f26\u6566\u65f6\u95f42018\u5e748\u670828\u65e5\u5728\u4f26\u6566\u8bc1\u5238\u4ea4\u6613\u6240\u53d1\u5e03\u4e86\u534e\u4e1c\u533b\u836f\u62df\u901a\u8fc7\u73b0\u91d1\u8981\u7ea6\u65b9\u5f0f\u6536\u8d2dSinclair\u5168\u90e8\u80a1\u4efd\u7684\u53ef\u80fd\u6027\u8981\u7ea6\u6536\u8d2d\u516c\u544a\uff0c\u7531\u5168\u8d44\u5b59\u516c\u53f8\u534e\u4e1c\u533b\u836f\u533b\u7f8e\u6295\u8d44(\u9999\u6e2f)\u6709\u9650\u516c\u53f8\u4f5c\u4e3a\u6536\u8d2d\u4e3b\u4f53\u8fdb\u884c\u5b9e\u65bd\u3002\u73b0\u91d1\u8981\u7ea6\u4ef7\u683c\u4e3a32\u4fbf\u58eb\/\u80a1\uff0c\u9884\u8ba1\u672c\u6b21\u6536\u8d2dSinclair\u5168\u90e8\u80a1\u4efd\u7684\u4ea4\u6613\u603b\u989d\u7ea6\u4e3a1.69\u4ebf\u82f1\u9551(\u7ea6\u5408\u4eba\u6c11\u5e0114.9\u4ebf\u5143)\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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1.<\/span><\/strong><\/span>\u6b27\u76df\u6279\u51c6Yescarta\u6cbb\u7597\u6210\u4eba\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624<\/span><\/strong><\/span><\/p>\n

\u5409\u5229\u5fb7\u65d7\u4e0b\u516c\u53f8Kite\u8fd1\u65e5\u5ba3\u5e03\uff0c\u6b27\u6d32\u59d4\u5458\u4f1a\uff08EC\uff09\u5df2\u6388\u4e88Yescarta\u00ae\uff08axicabtagene ciloleucel\uff09\u8425\u9500\u8bb8\u53ef\uff0c\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u548c\u539f\u53d1\u6027\u7eb5\u9694\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08PMBCL\uff09\u6210\u4eba\u60a3\u8005\uff0c\u4ed6\u4eec\u5148\u524d\u63a5\u53d7\u8fc7\u4e24\u6b21\u6216\u4ee5\u4e0a\u7684\u7cfb\u7edf\u6cbb\u7597\u3002\u8425\u9500\u8bb8\u53ef\u6279\u51c6axicabtagene ciloleucel\u7528\u4e8e\u6b27\u76df\u6210\u5458\u56fd\uff0c\u632a\u5a01\u3001\u51b0\u5c9b\u548c\u5217\u652f\u6566\u58eb\u767b\u7b4928\u4e2a\u56fd\u5bb6\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n

2.<\/span><\/strong><\/span>\u62dc\u8033\u8840\u53cb\u75c5\u7597\u6cd5\u4eca\u65e5\u83b7\u5f97FDA\u6279\u51c6<\/span><\/strong><\/span>
<\/p>\n

\u62dc\u8033\uff08Bayer\uff09\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u7684Jivi\uff08BAY94-9027\uff09\u83b7\u5f97FDA\u6279\u51c6\uff0c\u7528\u4e8e\u5e38\u89c4\u9884\u9632\u6027\u6cbb\u7597\u63a5\u53d7\u8fc7\u524d\u671f\u6cbb\u7597\u768412\u5c81\u4ee5\u4e0aA\u578b\u8840\u53cb\u75c5\u60a3\u8005\u3002\u6700\u521d\u5efa\u8bae\u7684\u9884\u9632\u6027\u6cbb\u7597\u65b9\u6848\u4e3a\u6bcf\u5468\u63a5\u53d7\u4e24\u6b21\u6ce8\u5c04\uff0c\u6839\u636e\u60a3\u8005\u51fa\u8840\u72b6\u51b5\u7684\u53d8\u5316\uff0c\u53ef\u4ee5\u5c06\u6ce8\u5c04\u9891\u7387\u51cf\u5c11\u5230\u6bcf\u96945\u5929\uff0c\u751a\u81f3\u66f4\u957f\u65f6\u95f4\u63a5\u53d7\u4e00\u6b21\u6ce8\u5c04\u3002\u540c\u65f6\uff0cFDA\u4e5f\u6279\u51c6\u8be5\u836f\u7269\u4f5c\u4e3a\u5e94\u6025\u7597\u6cd5\u6216\u5728\u624b\u672f\u524d\u63a7\u5236\u60a3\u8005\u51fa\u8840\u98ce\u9669\u7684\u9884\u9632\u6027\u7597\u6cd5\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n

3.<\/span><\/strong>\u7f8eFDA\u8b66\u544a\uff1a\u7cd6\u5c3f\u75c5SGLT2\u6291\u5236\u5242\u6216\u9020\u6210\u751f\u6b96\u5668\u4e25\u91cd\u611f\u67d3<\/span><\/strong>
<\/p>\n

\u65e5\u524d\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u53d1\u5e03\u8b66\u544a\u79f0\uff0c\u53d1\u73b0\u7cd6\u5c3f\u75c5\u60a3\u8005\u5728\u4f7f\u7528SGLT2\u6291\u5236\u5242\u540e\u51fa\u73b0\u4e86\u6570\u4f8b\u751f\u6b96\u5668\u5468\u56f4\u533a\u57df\u4e25\u91cd\u611f\u67d3\u7684\u75c5\u4f8b\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span>
<\/p>\n

4.<\/span><\/strong><\/span>\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u9996\u4e2a\u590d\u65b9\u6d17\u5242\u65b0\u836f\u7533\u8bf7\u83b7\u53d7\u7406 \u6216\u660e\u5e74\u521d\u4e0a\u5e02<\/span><\/strong><\/p>\n

8\u670829\u65e5\uff0cBausch Health\u516c\u53f8\u65d7\u4e0b\u76ae\u80a4\u79d1\u5904\u65b9\u836f\u516c\u53f8Ortho Dermatologics\u516c\u5e03\u79f0\uff0c\u7f8e\u56fdFDA\u5df2\u63a5\u53d7\u4e86DUOBRII\u6d17\u5242\uff08\u5364\u500d\u4ed6\u7d22\u4e19\u9178\u916f\u548c\u4ed6\u624e\u7f57\u6c40\uff0c\u53c8\u79f0IDP-118\uff09\u7528\u4e8e\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u5c40\u90e8\u6cbb\u7597\u7684\u65b0\u836f\u4e0a\u5e02\u7684\u91cd\u65b0\u7533\u8bf7\u3002\u6b64\u6b21\u7533\u8bf7\u5c5e\u4e8e\u7f8e\u56fdFDA\u836f\u7269\u7684II\u7c7b\u518d\u7533\u8bf7\uff0cPDUFA\u65e5\u671f\u4e3a2019\u5e742\u670815\u65e5\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7814\u53d1\u8fdb\u5c55<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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1.<\/span><\/strong><\/span>CRISPR\uff1a\u5168\u7403\u9996\u4e2a\u5927\u578b\u52a8\u7269\u7814\u7a76\u8bc1\u5b9e \u57fa\u56e0\u7597\u6cd5\u6709\u671b\u6839\u6cbb\u808c\u840e\u7f29<\/span><\/strong><\/span><\/p>\n

\u4eca\u5929\u7684\u9876\u5c16\u5b66\u672f\u671f\u520a\u300a\u79d1\u5b66\u300b\u4e0a\uff0c\u520a\u53d1\u4e86\u4e00\u9879\u91cd\u91cf\u7ea7\u7684\u6587\u7ae0\u3002\u6765\u81ea\u5fb7\u514b\u8428\u65af\u5927\u5b66\u897f\u5357\u533b\u5b66\u4e2d\u5fc3\u7684Eric Olson\u6559\u6388\u56e2\u961f\u8bc1\u5b9e\uff0c\u5229\u7528CRISPR\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff0c\u6211\u4eec\u6709\u671b\u6cbb\u7597\uff0c\u751a\u81f3\u662f\u6839\u6cbb\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u3002\u8fd9\u4e00\u8bbe\u60f3\u5df2\u5728\u5927\u578b\u52a8\u7269\u4e2d\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002CRISPR\u6280\u672f\u7684\u9886\u519b\u4eba\u7269\u4e4b\u4e00Jennifer Doudna\u6559\u6388\u5728\u542c\u5230\u8fd9\u5219\u62a5\u9053\u540e\u8868\u793a\u201c\u81ea\u5df1\u96be\u4ee5\u63a7\u5236\u5174\u594b\u4e4b\u60c5\u201d\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n

2.<\/span><\/strong><\/span>\u7f57\u6c0f\u91cd\u78c5\u8840\u53cb\u75c5\u65b0\u836f3\u671f\u6570\u636e\u79ef\u6781 \u51fa\u8840\u51cf\u5c1197%<\/span><\/strong><\/span><\/p>\n

\u7f57\u6c0f\u96c6\u56e2\uff08Roche Group\uff09\u6210\u5458\u57fa\u56e0\u6cf0\u514b\uff08Genentech\uff09\u5ba3\u5e03\uff0c\u51763\u671f\u7814\u7a76HAVEN 3\u7684\u5173\u952e\u6570\u636e\u53d1\u8868\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08NEJM\uff09\u4e0a\u3002\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86\u5728\u4f53\u5185\u4e0d\u542b\u56e0\u5b50VIII\u6291\u5236\u7269\u768412\u5c81\u53ca\u4ee5\u4e0aA\u578b\u8840\u53cb\u75c5\u60a3\u8005\u4e2d\uff0c\u6bcf\u5468\u6216\u6bcf\u4e24\u5468\u65bd\u7528\u4e00\u6b21Hemlibra\uff08emicizumab-kxwh\uff09\u8fdb\u884c\u9884\u9632\u6027\u6cbb\u7597\u7684\u7597\u6548\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n

3.<\/span><\/strong><\/span>\u79d1\u5b66\u5bb6\u53d1\u73b0\u9aa8\u9ad3\u514d\u75ab\u7ec6\u80de\u5feb\u901f\u8fdb\u5165\u5927\u8111\u7684\u79d8\u5bc6\u901a\u9053<\/span><\/strong><\/span><\/p>\n

\u9aa8\u9ad3\u662f\u4eba\u7c7b\u5927\u90e8\u5206\u9aa8\u9abc\u4e2d\u7684\u6d77\u7ef5\u7ec4\u7ec7\uff0c\u5b83\u80fd\u4ea7\u751f\u7ea2\u7ec6\u80de\u548c\u514d\u75ab\u7ec6\u80de\uff0c\u5e2e\u52a9\u62b5\u6297\u611f\u67d3\u3001\u6cbb\u6108\u521b\u4f24\u3002\u6839\u636e8\u670827\u65e5\u5728\u7ebf\u53d1\u8868\u4e8e\u300aNature Neuroscience\u300b\u6742\u5fd7\u4e0a\u7684\u4e00\u9879\u65b0\u7814\u7a76\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u9885\u9aa8\u9aa8\u9ad3\u81f3\u5927\u8111\u5185\u58c1\u5b58\u5728\u4e00\u6761\u5fae\u5c0f\u901a\u9053\uff0c\u53ef\u80fd\u4e3a\u514d\u75ab\u7ec6\u80de\u5bf9\u4e2d\u98ce\u548c\u5176\u4ed6\u8111\u90e8\u75be\u75c5\u9020\u6210\u7684\u635f\u4f24\u505a\u51fa\u53cd\u5e94\u63d0\u4f9b\u4e86\u5feb\u901f\u76f4\u63a5\u7684\u9014\u5f84\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span>
<\/p>\n

4.<\/span><\/strong><\/span>\u65b0\u578b\u766b\u75eb\u836f\u7269\u83b7\u79ef\u6781\u8fdb\u5c55 \u5c55\u73b0\u5f3a\u529b\u6291\u5236\u6548\u679c<\/span><\/strong><\/span>
<\/p>\n

\u65e5\u524d\uff0c\u52a0\u62ff\u5927\u4e34\u5e8a\u9636\u6bb5\u795e\u7ecf\u5b66\u533b\u836f\u516c\u53f8Xenon Pharmaceuticals\u5ba3\u5e03\uff0c\u5176\u9488\u5bf9\u766b\u75eb\u7684\u836f\u7269XEN1101\u5728\u4e34\u5e8a1b\u671f\u7ecf\u9885\u78c1\u523a\u6fc0\uff08TMS\uff09\u7814\u7a76\u4e2d\u83b7\u5f97\u79ef\u6781\u836f\u6548\u5b66\u6570\u636e\u3002XEN1101\u662f\u4e00\u6b3e\u53e3\u670dKv7\u94be\u901a\u9053\u5f00\u653e\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u766b\u75eb\u3002\u672c\u6b21\u7814\u7a76\u7684\u7ecf\u9885\u78c1\u523a\u6fc0\u808c\u7535\u56fe\uff08TMS-EMG\uff09\u4e0e\u8111\u7535\u56fe\uff08TMS-EEG\uff09\u6570\u636e\u7686\u663e\u793aXEN1101\u53ef\u4ee5\u663e\u8457\u964d\u4f4e\u76ae\u8d28\u810a\u9ad3\u53ca\u76ae\u8d28\u5174\u594b\u6027\u3002\uff08\u8be6\u89c1\u4e0b\u65b9\u9605\u8bfb\u539f\u6587\uff09<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5185\u5bb9\u6765\u6e90\uff1a<\/span><\/strong>\u751f\u7269\u63a2\u7d22\u3001\u751f\u7269\u8c37\u3001\u836f\u660e\u5eb7\u5fb7\u3001\u65b0\u4eac\u62a5\u3001\u6bcf\u65e5\u7ecf\u6d4e\u65b0\u95fb\u3001\u65b0\u6d6a\u533b\u836f\u65b0\u95fb\u3001\u592e\u89c6\u65b0\u95fb\u3001\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u3001\u65b0\u534e\u793e\u3001\u4e2d\u56fd\u8bc1\u5238\u7f51\u3001\u533b\u836f\u5730\u7406<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\"\u3010\u58f9\u5468\u836f\u8baf\u3011\u56fd\u52a1\u9662\u5b89\u6392\u4e8650\u4ef6\u533b\u836f\u5927\u4e8b\uff01602\u4e2a\u8fdb\u53e3\u836f\u53ca\u6297\u764c\u836f\u8981\u964d\u4ef7<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u672c\u5468\u89c6\u70b9 \u56fd\u52a1\u9662\u5b89\u6392\u4e8650\u4ef6\u533b\u836f\u5927\u4e8b \u4e0b\u534a\u5e74\u533b\u6539\u91cd\u70b9\u4efb\u52a1\u6765\u4e86\uff0c\u4e00\u517150\u9879\u3002\u6309\u75c5\u79cd\u4ed8\u8d39\u5168\u56fd\u63a8\u5e7f\u3001\u57fa\u836f\u76ee\u5f55\u5373\u5c06\u8c03\u6574 […]<\/p>\n","protected":false},"author":1,"featured_media":40599,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/40598"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=40598"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/40598\/revisions"}],"predecessor-version":[{"id":40601,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/40598\/revisions\/40601"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/40599"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=40598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=40598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=40598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}