{"id":40602,"date":"2018-08-31T01:00:00","date_gmt":"2018-09-17T06:43:59","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e6%b8%b8%e7%a6%bb%e7%99%8c%e7%bb%86%e8%83%9e%e7%ab%9f%e9%81%ad%e5%8f%8b%e5%86%9b%e5%8f%8d%e6%9d%80%ef%bc%81%e5%8e%9f%e5%8f%91%e8%82%bf%e7%98%a4%e7%bb%86%e8%83%9e%e4%b8%8a%e6%bc%94\/"},"modified":"2018-09-17T14:44:03","modified_gmt":"2018-09-17T06:44:03","slug":"%e6%b8%b8%e7%a6%bb%e7%99%8c%e7%bb%86%e8%83%9e%e7%ab%9f%e9%81%ad%e5%8f%8b%e5%86%9b%e5%8f%8d%e6%9d%80%ef%bc%81%e5%8e%9f%e5%8f%91%e8%82%bf%e7%98%a4%e7%bb%86%e8%83%9e%e4%b8%8a%e6%bc%94","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/40602\/","title":{"rendered":"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  class=\"_135editor\" style=\"font-size: 16px;white-space: normal;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"     style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"135brush\"  placeholder=\"\u6df1\u8272\u8fb9\u6846\u6807\u9898\" style=\"margin-top: 10px;margin-bottom: 10px;padding: 10px;line-height: 25px;color: rgb(109, 4, 14);border-radius: 4px;box-shadow: rgb(153, 153, 153) 2px 2px 4px 0px;border-left: 10px solid rgb(21, 59, 143);border-top-color: rgb(21, 59, 143);border-right-color: rgb(21, 59, 143);border-bottom-color: rgb(21, 59, 143);background-color: rgb(225, 227, 226);box-sizing: border-box;\">\n<p style=\"text-align: justify;\"><span style=\"letter-spacing: 0.544px;widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;color: rgb(0, 0, 0);text-indent: 28px;white-space: pre-wrap;font-size: 15px;\">8\u670827\u65e5\uff0c\u5728Nature\u7684\u5b50\u520a\u300aNature Cell 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!important;\">\u90a3\u5230\u5e95\u4ec0\u4e48\u662f\u80bf\u7624\u548c\u764c\u5462\uff1f<\/strong><\/p>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\">\u5b9e\u9645\u4e0a\uff0c\u80bf\u7624\u548c\u764c\u4e4b\u95f4\u65e2\u6709\u8054\u7cfb\uff0c\u53c8\u6709\u533a\u522b\u3002\u4ece\u5927\u4f17\u7684\u89c6\u89d2\u6765\u770b\uff0c\u90fd\u53ef\u4ee5\u53eb\u505a\u80bf\u7624\uff1b\u4f46\u5728\u533b\u5b66\u89d2\u5ea6\uff0c\u5176\u5dee\u522b\u4e3b\u8981\u5728\u75c5\u7406\u5b66\u3002\u80bf\u7624\u5206\u4e3a\u826f\u6027\u80bf\u7624\u4e0e\u6076\u6027\u80bf\u7624\u3002\u826f\u6027\u80bf\u7624\u662f\u6307\u65e0\u6d78\u6da6\u548c\u8f6c\u79fb\u80fd\u529b\u7684\u80bf\u7624\u3002\u6076\u6027\u80bf\u7624\u53ef\u4ee5\u7406\u89e3\u4e3a\u901a\u5e38\u610f\u4e49\u4e0a\u7684\u764c\u75c7\u3002\u6253\u6bd4\u65b9\u8bf4\uff0c\u80bf\u7624\u5c31\u662f\u5728\u53cb\u597d\u5171\u5904\u7684\u60c5\u51b5\u4e0b\u5e76\u5b58\uff0c\u800c\u764c\u75c7\u5c31\u610f\u5473\u7740\u7834\u574f\u4e0e\u6bc1\u706d\u3002\u80bf\u7624\u7edd\u5927\u90e8\u5206\u6001\u5ea6\u53cb\u597d\uff0c\u764c\u75c7\u7ec6\u80de\u5c31\u662f\u6709\u4e9b\u4efb\u6027\uff0c\u975e\u8981\u628a\u522b\u4eba\u7684\u5730\u65b9\u5360\u4e3a\u5df1\u6709\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section class=\"_135editor\"   style=\"white-space: normal;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;font-size: 12px;max-width: 100%;color: rgb(62, 62, 62);height: 32px;border-bottom: 1px solid rgb(227, 227, 227);line-height: 18px;word-wrap: break-word !important;box-sizing: border-box !important;\"><strong class=\"135brush\"  style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;border-bottom: 2px solid rgb(0, 0, 0);border-top-color: rgb(0, 0, 0);border-right-color: rgb(0, 0, 0);border-left-color: rgb(0, 0, 0);color: rgb(0, 0, 0);display: block;float: left;font-size: 16px;line-height: 28px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u80bf\u7624\u5982\u4f55\u6291\u5236\u764c\u7ec6\u80de\u5462\uff1f<\/strong><\/p>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\">8\u670827\u65e5\uff0c\u5728Nature\u7684\u5b50\u520a\u300aNature Cell Biology\u300b\uff08\u7ec6\u80de\u9886\u57df\u7684\u4e07\u5e74\u8001\u4e8c\uff0c\u7b2c\u4e00\u5f53\u7136\u662f\u300aCell\u300b\uff09\u4e2d\uff0c\u53d1\u8868\u4e86\u4e00\u7bc7\u6709\u8da3\u7684\u6587\u7ae0\u3002\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u5c0f\u9f20\u7684\u539f\u751f\u80bf\u7624\u7adf\u7136\u963b\u6b62\u4e86\u764c\u7ec6\u80de\u7684\u6269\u6563\u3002\u901a\u8fc7\u5bf9\u5c0f\u9f20\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u5982\u679c\u5c0f\u9f20\u4f53\u5185\u5df2\u7ecf\u5f62\u6210\u4e86\u80bf\u7624\uff0c\u6e38\u79bb\u7684\u764c\u7ec6\u80de\u5c31\u5f88\u96be\u53d1\u5c55\u6210\u80bf\u7624\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537166640.jpg\" alt=\"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053\" title=\"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053\"  \/><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"caret-color: red;font-size: 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15px;\">\u4e5f\u5c31\u662f\u8bf4\uff0c\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u7adf\u7136\u5728\u673a\u4f53\u5185\u4e0a\u6f14\u4e86\u4e00\u51fa\u201c\u65e0\u95f4\u9053\u201d\uff0c\u628a\u201c\u6f02\u6cca\u201d\u5728\u5916\u7684\u764c\u7ec6\u80de\u201c\u53cd\u6740\u201d\u4e86\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537166640.jpeg\" alt=\"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053\" title=\"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053\"  \/><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"caret-color: red;font-size: 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title=\"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053\"  \/><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"caret-color: red;font-size: 15px;\">\u8fd9\u7bc7\u6587\u7ae0\u4ece\u5c0f\u9f20\u5b9e\u9a8c\u7814\u7a76\u548c\u60a3\u8005\u6837\u672c\u5206\u6790\u4e24\u4e2a\u65b9\u9762\u89e3\u7b54\u4e86\u4e0a\u8ff0\u7591\u95ee\u3002\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u9996\u5148\u5728\u5c0f\u9f20\u4f53\u5185\u6784\u5efa\u80bf\u7624\uff0c\u5e76\u5728\u4e24\u5468\u540e\uff0c\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u764c\u7ec6\u80de\uff0c\u6a21\u62df\u80bf\u7624\u7684\u6269\u6563\u8fc7\u7a0b\u3002\u7ed3\u679c\u53d1\u73b0\uff0c\u539f\u53d1\u6027\u80bf\u7624\u8bf1\u53d1\u5c0f\u9f20\u80ba\u90e8\u4e2d\u767d\u7ec6\u80de\u4ecb\u7d20-1\u03b2\uff08IL-1\u03b2\uff09\u9ad8\u6c34\u5e73\u8868\u8fbe\uff0c\u4ece\u800c\u5f15\u8d77\u4e86\u708e\u75c7\u53cd\u5e94\uff0c\u6291\u5236\u4e86\u80ba\u90e8\u764c\u7ec6\u80de\u7684\u751f\u957f\u3002\u800c\u5f53IL-1\u03b2\u88ab\u6291\u5236\u65f6\uff0c\u80ba\u90e8\u764c\u7ec6\u80de\u7684\u8f6c\u79fb\u53cd\u800c\u589e\u52a0\u3002\u540c\u6837\u5728\u5206\u6790\u4e73\u817a\u764c\u60a3\u8005\u7684\u6837\u672c\u65f6\uff0c\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0IL-1\u03b2\u6c34\u5e73\u9ad8\u7684\u60a3\u8005\u8f6c\u79fb\u6027\u80bf\u7624\u7684\u98ce\u9669\u66f4\u4f4e\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\"><em>\u201c\u867d\u7136\u708e\u75c7\u53ef\u4ee5\u5e2e\u52a9\u80bf\u7624\u7ec6\u80de\u9003\u9038\uff0c\u5e76\u5728\u4f53\u5185\u7684\u5176\u5b83\u90e8\u4f4d\u201c<\/em><em>\u5b89\u8425\u624e\u5be8\u201d<\/em><em>\u3002\u4f46\u5982\u679c\u7740\u9646\u65f6\u53d1\u751f\u708e\u75c7\uff0c\u673a\u4f53\u7684\u514d\u75ab\u7ec6\u80de\u5c31\u4f1a\u8fdb\u884c\u68c0\u67e5\u5e76\u8fdb\u884c\u201c\u626b\u8361\u201d\u3002\u56e0\u6b64\u53ea\u6709\u5728\u708e\u75c7\u88ab\u6291\u5236\u65f6\uff0c\u764c\u7ec6\u80de\u624d\u4f1a\u957f\u51fa\u6765\u3002\u201d<\/em><\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section class=\"_135editor\"   style=\"white-space: normal;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;font-size: 12px;max-width: 100%;color: rgb(62, 62, 62);height: 32px;border-bottom: 1px solid rgb(227, 227, 227);line-height: 18px;word-wrap: break-word !important;box-sizing: border-box !important;\"><strong class=\"135brush\"  style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;border-bottom: 2px solid rgb(0, 0, 0);border-top-color: rgb(0, 0, 0);border-right-color: rgb(0, 0, 0);border-left-color: rgb(0, 0, 0);color: rgb(0, 0, 0);display: block;float: left;font-size: 16px;line-height: 28px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4ec0\u4e48\u662f\u767d\u7ec6\u80de\u4ecb\u7d20\u5462\uff1f<\/strong><\/p>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\">\u767d\u7ec6\u80de\u4ecb\u7d20\uff08Interleukin, IL\uff09\u5373\u662f\u7531\u591a\u79cd\u7ec6\u80de\u4ea7\u751f\u5e76\u4f5c\u7528\u4e8e\u591a\u79cd\u7ec6\u80de\u7684\u4e00\u7c7b\u7ec6\u80de\u56e0\u5b50\u3002\u76ee\u524d\u81f3\u5c11\u53d1\u73b0\u4e8638\u79cd\u767d\u7ec6\u80de\u4ecb\u7d20\uff0c\u5206\u522b\u547d\u540d\u4e3aIL-1~IL38\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\">\u800c\u767d\u7ec6\u80de\u4ecb\u7d20-1\uff08IL-1\uff09\u53c8\u540d\u6dcb\u5df4\u7ec6\u80de\u523a\u6fc0\u56e0\u5b50\u3002\u4e3b\u8981\u7531\u6d3b\u5316\u7684\u5355\u6838\uff0d\u5de8\u566c\u7ec6\u80de\u4ea7\u751f\u3002\u5176\u7ed3\u6784\u6709IL-1\u03b1\u548cIL-1\u03b2\u4e24\u79cd\u5b58\u5728\u5f62\u5f0f\u3002IL\u20431\u03b1\u4e3b\u8981\u8868\u8fbe\u4e8e\u7ec6\u80de\u8868\u9762\u6216\u7ec6\u80de\u5185\uff1b\u800cIL\u2043 1\u03b2\u4e3b\u8981\u7531\u7ec6\u80de\u91ca\u653e\u51fa\u6765\uff0c\u901a\u8fc7\u4f5c\u7528\u4e8e\u5176\u4ed6\u7ec6\u80de\u800c\u53d1\u6325\u5176\u6548\u5e94\u3002\u5176\u4e2d IL\u20431\u03b2\u662fIL\u20431\u7684\u4e3b\u8981\u5206\u6ccc\u5f62\u5f0f\uff0c\u662f\u708e\u75c7\u514d\u75ab\u53cd\u5e94\u8c03\u63a7\u56e0\u5b50\uff0c\u53ef\u964d\u4f4e\u75db\u9608\u3001\u635f\u4f24\u7ec4\u7ec7\uff0c\u8bf1\u53d1\u708e\u6027\u53cd\u5e94\u53ca\u673a\u4f53\u9632\u5fa1\u53cd\u5e94\u3002<span style=\"caret-color: red;\">&nbsp;<\/span><\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section class=\"_135editor\"   style=\"white-space: normal;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;font-size: 12px;max-width: 100%;color: rgb(62, 62, 62);height: 32px;border-bottom: 1px solid rgb(227, 227, 227);line-height: 18px;word-wrap: break-word !important;box-sizing: border-box !important;\"><strong class=\"135brush\"  style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;border-bottom: 2px solid rgb(0, 0, 0);border-top-color: rgb(0, 0, 0);border-right-color: rgb(0, 0, 0);border-left-color: rgb(0, 0, 0);color: rgb(0, 0, 0);display: block;float: left;font-size: 16px;line-height: 28px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u767d\u7ec6\u80de\u4ecb\u7d20-1\u6709\u54ea\u4e9b\u836f\u7269\u5462\uff1f<\/strong><\/p>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\">\u6839\u636e\u4e2d\u56fd\u65b0\u836f\u7814\u53d1\u76d1\u6d4b\u6570\u636e\u5e93\uff08CPM\uff09\u663e\u793a\uff0c\u76ee\u524d\u5168\u7403\u5e02\u573a\u4e0a\u5e02\u7684\u767d\u7ec6\u80de\u4ecb\u7d20-1\uff08IL-1\uff09\u836f\u7269\u5171\u67093\u79cd\u7c7b\u578b\uff0c\u5e76\u4e14\u4f5c\u7528\u673a\u5236\u90fd\u662f\u963b\u65adIL-1\u3002\u5206\u522b\u4e3a\u963f\u90a3\u767d\u6ede\uff08Anakinra\uff09\u3001\u5361\u90a3\u5355\u6297\uff08Canakinumab\uff09\u548cRilonacept\uff08IL-1 Trap\uff09\u3002\u4f46\u5361\u90a3\u5355\u6297\u4e0e\u5176\u4ed6\u4e24\u79cd\u836f\u7269\u4e0d\u540c\u7684\u662f\uff0c\u5b83\u662f\u76f4\u63a5\u9488\u5bf9\u767d\u7ec6\u80de\u4ecb\u7d20-1\u03b2\u7684\u6297\u4f53\u7c7b\u836f\u7269\u3002\u4e0e\u963f\u90a3\u767d\u6ede\u548cRilonacept\u4e24\u79cd\u836f\u7269\u76f8\u6bd4\uff0c\u5361\u90a3\u5355\u6297\u534a\u8870\u671f\u975e\u5e38\u957f\u3002\u5176\u4e00\u5e74\u7684\u6cbb\u7597\u8d39\u7528\u5927\u7ea6\u57286\u4e07\u7f8e\u5143\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537166641.jpg\" alt=\"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053\" title=\"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053\"  \/><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\">\u5176\u4e2d\uff0c\u8bfa\u534e\u7684\u5361\u90a3\u5355\u6297\u548c\u518d\u751f\u5143\u7684Rilonacept\u5747\u8fdb\u5165\u4e86\u6211\u56fd\u4eca\u5e748\u67088\u65e5\u53d1\u5e03\u7684\u300a\u5883\u5916\u5df2\u4e0a\u5e02\u4e34\u5e8a\u6025\u9700\u65b0\u836f\u540d\u5355\u300b\u5185\u3002\u8be5\u540d\u5355\u5185\u836f\u7269\uff0c\u65e0\u9700\u5728\u6211\u56fd\u518d\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5747\u53ef\u63d0\u4ea4\u6216\u8865\u4ea4\u5883\u5916\u53d6\u5f97\u7684\u5168\u90e8\u7814\u7a76\u8d44\u6599\u548c\u4e0d\u5b58\u5728\u4eba\u79cd\u5dee\u5f02\u7684\u652f\u6301\u6027\u6750\u6599\uff0c\u76f4\u63a5\u63d0\u51fa\u4e0a\u5e02\u7533\u8bf7\uff0c\u5e76\u6309\u7167\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u7a0b\u5e8f\uff0c\u52a0\u5feb\u5ba1\u8bc4\u5ba1\u6279\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\"><strong>\u76f4\u63a5\u4f5c\u7528\u4e8eIL -1<\/strong><strong>\u03b2\u7684\u836f\u7269\u2014\u2014Canakinumab<\/strong><strong>\uff08\u5361\u90a3\u5355\u6297\uff09<\/strong><\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\">\u5361\u90a3\u5355\u6297\u662f\u8bfa\u534e\u7814\u53d1\u7684\u4e00\u6b3e\u9776\u5411\u767d\u7ec6\u80de\u4ecb\u7d20-1\u03b2\u7684\u5355\u6297\u836f\u7269\uff0c\u5b83\u5df2\u7ecf\u662f\u836f\u7269\u754c\u7684\u201c\u8001\u53f8\u673a\u201d\u4e86\uff0c\u8fc7\u5f80\u7684\u6210\u7ee9\u5355\u4e5f\u53ef\u4ee5\u7b97\u662f\u4f18\u79c0\uff0c\u57282009\u5e74\u5c31\u88abFDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u7f55\u89c1\u81ea\u8eab\u514d\u75ab\u75be\u75c5Cryopyrin\u86cb\u767d\u76f8\u5173\u5468\u671f\u7efc\u5408\u5f81\uff08CAPS\uff09\u3002FDA\u53c8\u57282016\u5e74\u6279\u51c6\u5b83\u6cbb\u7597\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\u76f8\u5173\u7684\u5468\u671f\u6027\u7efc\u5408\u5f81\uff08TRAPS\uff09\u3001\u9ad8\u514d\u75ab\u7403\u86cb\u767dD\u7efc\u5408\u5f81\uff08HIDS\uff09\/\u7532\u7f9f\u620a\u9178\u6fc0\u9176\u7f3a\u4e4f\u75c7\uff08MKD\uff09\u548c\u5bb6\u65cf\u6027\u5730\u4e2d\u6d77\u70ed\uff08FMF\uff09\u8fd9\u4e09\u79cd\u7f55\u89c1\u7684\u81ea\u8eab\u708e\u75c7\u6027\u75be\u75c5\u3002\u5bf9\u4e8e\u8fd9\u4e09\u79cd\u75be\u75c5\u6765\u8bf4\uff0c\u5361\u90a3\u5355\u6297\u662f\u552f\u4e00\u7684\u83b7\u6279\u836f\u7269\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\">\u6839\u636e\u836f\u7269\u7efc\u5408\u6570\u636e\u5e93\uff08PDB\uff09\u663e\u793a\uff0c2017\u5e74\u5361\u90a3\u5355\u6297\u7684\u5168\u7403\u9500\u552e\u4e3a4.2\u4ebf\u7f8e\u5143\uff0c\u590d\u5408\u589e\u957f\u7387\u8d85\u8fc735%\uff0c\u5e02\u573a\u589e\u901f\u4e0d\u65ad\u63d0\u5347\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537166642.jpg\" alt=\"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053\" title=\"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053\"  \/><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\">\u4ece\u7814\u53d1\u5e03\u5c40\u65b9\u9762\u53ef\u4ee5\u770b\u51fa\uff0c\u8bfa\u534e\u5bf9\u8be5\u836f\u7269\u7684\u91ce\u5fc3\u4e0d\u5c0f\u3002\u5728\u5168\u90e8\u768451\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8d85\u8fc740%\u90fd\u5df2\u7ecf\u5230\u4e86\u4e34\u5e8aIII\u671f\u3002\u5e76\u4e14\u7531\u4e8eIL-1\u03b2\u662f\u708e\u75c7\u4fe1\u53f7\u901a\u8def\u7684\u5173\u952e\u5206\u5b50\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u7cd6\u5c3f\u75c5\u53c8\u88ab\u8ba4\u4e3a\u4e0e\u708e\u75c7\u6709\u5173\uff0c\u4e8e\u662f\u8bfa\u534e\u5f00\u5c55\u4e86\u5927\u91cf\u7684\u76f8\u5173\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5176\u4e2d\uff0c\u4ee3\u53f7\u4e3aCANTOS\uff08NCT01327846\uff09\u7684III\u671f\u708e\u75c7\u6027\u5fc3\u8840\u7ba1\u75c5\u60a3\u8005\u7684\u7814\u7a76\u7adf\u7136\u7eb3\u5165\u4e86\u8d85\u8fc71\u4e07\u4f8b\u60a3\u8005\uff0c\u8fd9\u662f\u8bfa\u534e\u5f00\u5c55\u7684\u89c4\u6a21\u6700\u5927\u7684\u5fc3\u8840\u7ba1\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8fc4\u4eca\u4e3a\u6b62\u5df2\u6301\u7eed\u4e867\u5e74\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537166642.jpg\" alt=\"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053\" title=\"\u6e38\u79bb\u764c\u7ec6\u80de\u7adf\u906d\u201c\u53cb\u519b\u201d\u53cd\u6740\uff01\u539f\u53d1\u80bf\u7624\u7ec6\u80de\u4e0a\u6f14\u201c\u65e0\u95f4\u9053\"  \/><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section class=\"_135editor\"   style=\"white-space: normal;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;font-size: 12px;max-width: 100%;color: rgb(62, 62, 62);height: 32px;border-bottom: 1px solid rgb(227, 227, 227);line-height: 18px;word-wrap: 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