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Mulpleta\u4e0eDoptelet\u4e24\u8005\u5747\u6709\u5e02\u573a\u8feb\u5207\u9700\u6c42\uff0c\u53d7\u5230\u5173\u6ce8\u3002<\/span>
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 \u5168\u65871950\u5b57\uff0c\u7528\u65f64\u5206\u949f<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4f5c\u8005\uff1a\u8bb8\u5173\u715c\u3001\u674e\u654f\u534e<\/span><\/p>\n

\u8840\u5c0f\u677f\u662f\u5728\u9aa8\u9ad3\u4e2d\u4ea7\u751f\u7684\u65e0\u8272\u7ec6\u80de\uff0c\u5176\u6709\u52a9\u4e8e\u5728\u8840\u7ba1\u7cfb\u7edf\u4e2d\u5f62\u6210\u8840\u51dd\u5757\u5e76\u9632\u6b62\u51fa\u8840\u3002\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u662f\u8840\u6db2\u4e2d\u5faa\u73af\u7684\u8840\u5c0f\u677f\u6570\u4f4e\u4e8e\u6b63\u5e38\u503c\u7684\u75c5\u75c7\u3002\u5f53\u60a3\u8005\u8840\u5c0f\u677f\u8ba1\u6570\u4e2d\u5ea6\u81f3\u4e25\u91cd\u51cf\u5c11\u65f6\uff0c\u53ef\u80fd\u53d1\u751f\u4e25\u91cd\u6216\u5371\u53ca\u751f\u547d\u7684\u51fa\u8840\uff0c\u7279\u522b\u662f\u5728\u4fb5\u5165\u6027\u624b\u672f\u671f\u95f4\u3002\u5177\u6709\u663e\u8457\u8840\u5c0f\u677f\u51cf\u5c11\u7684\u60a3\u8005\u901a\u5e38\u5728\u624b\u672f\u524d\u7acb\u5373\u63a5\u53d7\u8840\u5c0f\u677f\u8f93\u6ce8\u4ee5\u589e\u52a0\u8840\u5c0f\u677f\u8ba1\u6570\u3002\u4f46\u8840\u5c0f\u677f\u8f93\u6ce8\u6709\u611f\u67d3\u98ce\u9669\u53ca\u5176\u5b83\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/p>\n

\u76d0\u91ce\u4e49\u7684<\/strong>Lusutrombopag<\/strong><\/span><\/p>\n

7\u670831\u65e5\uff0c\u7f8e\u56fdFDA\u5728\u5b8c\u6210\u4f18\u5148\u5ba1\u67e5\u540e\uff0c\u6279\u51c6\u4e86\u76d0\u91ce\u4e49\u516c\u53f8\u7684Mulpleta\uff08Lusutrombopag\uff09\uff0c\u8fd9\u79cd\u6bcf\u65e5\u53e3\u670d\u7ed9\u836f\u7684\u5c0f\u5206\u5b50\u8840\u5c0f\u677f\u751f\u6210\u7d20\uff08TPO\uff09\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u8ba1\u5212\u63a5\u53d7\u624b\u672f\u7684\u6210\u4eba\u6162\u6027\u809d\u75c5\uff08CLD\uff09\u60a3\u8005\u7684\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3002<\/span><\/p>\n

\u5728CLD\u60a3\u8005\u4e2d\u7ecf\u5e38\u53ef\u89c2\u5bdf\u5230\u8840\u5c0f\u677f\u51cf\u5c11\uff0c\u7814\u7a76\u8868\u660e\u5b83\u5728\u809d\u786c\u5316\u60a3\u8005\u4e2d\u53d1\u751f\u6bd4\u4f8b\u9ad8\u8fbe78%\u3002\u4e0eCLD\u76f8\u5173\u7684\u8840\u5c0f\u677f\u51cf\u5c11\u5b9a\u4e49\u4e3a\u8840\u5c0f\u677f\u8ba1\u6570\u4f4e\u4e8e15\u4e07\/\u5fae\u5347\uff0cCLD\u8840\u5c0f\u677f\u51cf\u5c11\u4f7f\u51fa\u8840\u98ce\u9669\u589e\u52a0\uff0c\u9700\u8981\u53cd\u590d\u8f93\u6ce8\u8840\u5c0f\u677f\uff0c\u4ece\u800c\u589e\u52a0\u95e8\u8bca\u4e92\u8bbf\u548c\u4f4f\u9662\u3002\u6709\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7684CLD\u60a3\u8005\u6bcf\u5e74\u533b\u7597\u8d39\u7528\u6bd4\u65e0\u8840\u5c0f\u677f\u51cf\u5c11\u7684CLD\u60a3\u8005\u9ad8\u51fa3\u500d\u3002\u5f53\u8840\u5c0f\u677f\u8ba1\u6570\u4f4e\u4e8e5\u4e07\/\u5fae\u5347\u65f6\uff0c\u66f4\u4f1a\u52a0\u5267\u624b\u672f\u6216\u5916\u4f24\u51fa\u8840\uff0c\u5e76\u4e14\u4f7f\u5e38\u89c4\u8bca\u65ad\u7a0b\u5e8f\u548c\u60a3\u8005\u62a4\u7406\u660e\u663e\u590d\u6742\u5316\u3002\u56e0\u6b64\uff0c\u8fd9\u4e00\u9886\u57df\u8feb\u5207\u9700\u8981\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u60a3\u540c\u65f6\uff0c\u6709\u6162\u6027\u809d\u75c5\u7684\u6210\u5e74\u60a3\u8005\u5f80\u5f80\u7531\u4e8e\u5404\u79cd\u539f\u56e0\u9700\u8981\u8fdb\u884c\u624b\u672f\uff0c\u80fd\u591f\u4e3a\u60a3\u8005\u63d0\u4f9b\u8fd9\u79cd\u65b0\u7684\u53e3\u670d\u6cbb\u7597\uff0c\u5c31\u4e0d\u5fc5\u4f9d\u9760\u8840\u5c0f\u677f\u8f93\u6ce8\u3002<\/span><\/p>\n

Mulpleta\uff08Lusutrombopag\uff09\u4e0e\u5de8\u6838\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u4ebaTPO\u53d7\u4f53\u7684\u8de8\u819c\u7ed3\u6784\u57df\u76f8\u4e92\u4f5c\u7528\uff0c\u8bf1\u5bfc\u5de8\u6838\u7ec6\u80de\u7956\u7ec6\u80de\u4ece\u9020\u8840\u5e72\u7ec6\u80de\u548c\u5de8\u6838\u7ec6\u80de\u6210\u719f\u7684\u589e\u6b96\u548c\u5206\u5316\u3002<\/span><\/p>\n

FDA\u6279\u51c6Mulpleta\u662f\u57fa\u4e8e\u4e24\u9879III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08L-PLUS 1\u548cL-PLUS 2\uff09\uff0cMulpleta\u6ee1\u8db3\u4e3b\u8981\u548c\u6b21\u8981\u7ec8\u70b9\uff0c\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u7ed3\u679c\u3002<\/span><\/p>\n

2015\u5e749\u6708\uff0cMulpleta\u83b7\u5f97\u65e5\u672c\u539a\u751f\u52b3\u52a8\u7701\u7684\u6279\u51c6\uff0c\u7528\u4e8e\u6539\u5584\u63a5\u53d7\u9009\u62e9\u6027\u4fb5\u5165\u6027\u624b\u672f\u7684\u60a3\u8005\u4e0eCLD\u76f8\u5173\u7684\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3002\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u4e5f\u5df2\u7ecf\u9a8c\u8bc1\u4e86\u76d0\u91ce\u4e49\u7684lusutrombopag\u6807\u51c6\u8425\u9500\u6388\u6743\u7533\u8bf7\u5ba1\u67e5\uff0c\u9884\u8ba1\u5c06\u4e8e2019\u5e74\u4e0a\u534a\u5e74\u83b7\u5f97\u6279\u51c6\u3002<\/span><\/p>\n

\u5728\u7f8e\u56fd\uff0c\u9884\u8ba1Mulpleta\u5c06\u4e8e2018\u5e749\u6708\u521d\u4e0a\u5e02\u3002<\/span><\/p>\n

AkaRx<\/strong>\u516c\u53f8\u7684<\/strong>Avatrombopag<\/strong><\/span><\/p>\n

5\u670821\u65e5\uff0cDova\u65d7\u4e0bAkaRx\u516c\u53f8\u7684Doptelet\uff08Avatrombopag\uff09\u83b7\u5f97FDA\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u8ba1\u5212\u63a5\u53d7\u53e3\u8154\u79d1\u6216\u5176\u5b83\u624b\u672f\u7684\u6162\u6027\u809d\u75c5\u6210\u4eba\u4f4e\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3002\u5b83\u662fFDA\u6279\u51c6\u7684\u7b2c\u4e00\u79cd\u7528\u4e8e\u6b64\u7528\u9014\u7684\u836f\u7269\u3002<\/span><\/p>\n

Doptelet\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5728\u4e24\u9879\u8bd5\u9a8c\uff08ADAPT-1\u548cADAPT-2\uff09\u4e2d\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u6d89\u53ca435\u540d\u60a3\u6709\u6162\u6027\u809d\u75c5\u548c\u4e25\u91cd\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7684\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u8ba1\u5212\u63a5\u53d7\u901a\u5e38\u9700\u8981\u8840\u5c0f\u677f\u8f93\u6ce8\u7684\u624b\u672f\u3002\u8bd5\u9a8c\u7814\u7a76\u4e86\u4e0e\u5b89\u6170\u5242\uff08\u672a\u6cbb\u7597\uff09\u76f8\u6bd4\uff0c\u57285\u5929\u5185\u53e3\u670d\u7ed9\u836f\u7684\u4e24\u79cd\u5242\u91cf\u6c34\u5e73Doptelet\u3002\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u5bf9\u4e8e\u670d\u7528\u4e24\u79cd\u5242\u91cf\u6c34\u5e73\u7684Doptelet\uff0c\u8f83\u9ad8\u6bd4\u4f8b\u60a3\u8005\u8840\u5c0f\u677f\u8ba1\u6570\u589e\u52a0\uff0c\u5e76\u4e14\u5728\u624b\u672f\u5f53\u5929\u548c\u624b\u672f\u540e7\u5929\u5185\u4e0d\u9700\u8981\u8840\u5c0f\u677f\u8f93\u6ce8\u6216\u4efb\u4f55\u633d\u6551\u6cbb\u7597\u3002<\/span><\/p>\n

\u53d7\u5230\u5e02\u573a\u5173\u6ce8<\/strong><\/span><\/p>\n

Mulpleta\u4e0eDoptelet\u4e24\u8005\u5747\u6709\u5e02\u573a\u8feb\u5207\u9700\u6c42\uff0c\u53d7\u5230\u5173\u6ce8\u3002<\/span><\/p>\n

\u76d0\u91ce\u4e49\u7684Mulpleta\u4e0eAkaRx\u516c\u53f8\u7684Doptelet\u5728\u5b89\u5168\u6027\u3001\u529f\u6548\u548c\u7ed9\u836f\u65b9\u4fbf\u6027\u65b9\u9762\u975e\u5e38\u76f8\u4f3c\u3002\u76d0\u91ce\u4e49\u8d62\u5f97\u4e86FDA\u5bf9Mulpleta\u7684\u8ba4\u53ef\uff0c\u7136\u800cAkaRx\u7684Doptelet\u5728\u7f8e\u56fd\u6279\u51c6\u6bd4Mulpleta\u65e92\u4e2a\u6708\uff0c\u53ef\u4ee5\u9884\u89c1\uff0c\u4e24\u8005\u7684\u7ade\u4e89\u5c06\u662f\u6fc0\u70c8\u3002<\/span><\/p>\n

\u6709\u5206\u6790\u5e08\u8868\u793a\uff0c\u7ade\u4e89\u5c06\u83b7\u5f97\u7a0b\u5ea6\u53d6\u51b3\u4e8e\u5e02\u573a\u51c6\u5165\u548c\u5b9a\u4ef7\u7b56\u7565\u3002\u76d0\u91ce\u4e49\u7684Mulpleta\uff08lusutrombopag\uff09\u5df2\u5728\u65e5\u672c\u83b7\u5f97\u6279\u51c6\uff0c\u5e76\u6709\u4e24\u9879\u4e34\u5e8a\u7814\u7a76\u8bc1\u660e\u5176\u75c5\u4f8b\u3002\u5728\u8fd9\u4e24\u9879\u8bd5\u9a8c\u4e2d\uff0c\u5206\u522b\u670978\uff05\u548c65\uff05\u7684\u60a3\u8005\u5728\u624b\u672f\u524d\u4e0d\u9700\u8981\u8840\u5c0f\u677f\u8f93\u6ce8\uff0c\u4f18\u4e8e\u5b89\u6170\u5242\u7ec4\u768413\uff05\u548c29\uff05\u3002<\/span><\/p>\n

\u4e0eDoptelet\u76f8\u6bd4\uff0cMulpleta\u867d\u7136\u4e34\u5e8a\u5e94\u7b54\u7387\u8f83\u4f4e\uff0c\u4f46Leerink\u7684\u5206\u6790\u5e08Geoffrey Porges\u6307\u51fa\uff0c\u76d0\u91ce\u4e49\u7684\u7ec8\u70b9\u6bd4\u8f83\u4e25\u683c\u3002\u56e0\u6b64\uff0c\u4ed6\u8ba4\u4e3a\u8fd9\u4e24\u79cd\u836f\u7269\u201c\u4f3c\u4e4e\u6ca1\u6709\u51fa\u73b0\u529f\u6548\u5dee\u5f02\u201d\u3002<\/span><\/p>\n

\u5c31\u7ed9\u836f\u65b9\u4fbf\u6027\u65b9\u9762\u800c\u8a00\uff0c\u4e24\u79cd\u836f\u7269\u6709\u5404\u81ea\u7684\u4f18\u52bf\u3002\u4e0e\u4e00\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4f7f\u7528\u7684\u590d\u6742\u5242\u91cf\u65b9\u6848\u4e0d\u540c\uff0cMulpleta\u7684\u8bf4\u660e\u4e66\u6307\u51fa\u5b83\u4f7f\u7528\u56fa\u5b9a\u5242\u91cf7\u5929\uff0c\u6bd4Doptelet\u6240\u9700\u7684\u6807\u51c65\u5929\u66f4\u957f\u3002<\/span><\/p>\n

\u7136\u800c\uff0c\u6b63\u5982Evercore ISI\u5206\u6790\u5e08Jon Miller\u548cUmer Raffat\u6307\u51fa\u7684\u90a3\u6837\uff0cMulpleta\u53ef\u4ee5\u5728\u9884\u5b9a\u8fdb\u884c\u624b\u672f\u524d8\u523014\u5929\u5f00\u59cb\uff0c\u800cDoptelet\u7684\u7a97\u53e3\u572810\u523013\u5929\uff0c\u6bd4\u8f83\u72ed\u7a84\u3002Mulpleta\u66f4\u9614\u7684\u65f6\u95f4\u7a97\u53e3\u53ef\u80fd\u4f1a\u4f7f\u624b\u672f\u8ba1\u5212\u66f4\u5bb9\u6613\u5b89\u6392\u3002\u6b64\u5916\uff0c\u60a3\u8005\u53ef\u4ee5\u5728\u63a5\u8fd1\u5df2\u7ecf\u9884\u5b9a\u624b\u672f\u65e5\u671f\u7528\u836f\uff0c\u5982\u679c\u8840\u7ec6\u80de\u51cf\u5c11\u95ee\u9898\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\u51fa\u73b0\uff0c\u5219\u7ed9\u836f\u66f4\u5bb9\u6613\u3002<\/span><\/p>\n

\u7531\u4e8e\u4e24\u79cd\u836f\u7269\u7684\u7279\u5f81\u975e\u5e38\u76f8\u4f3c\uff0cLeerink\u548cEvercore\u56e2\u961f\u90fd\u8ba4\u4e3a\u5b9a\u4ef7\u7b56\u7565\u5c06\u662f\u8fd9\u4e24\u79cd\u836f\u54c1\u62c9\u5f00\u5dee\u8ddd\u7684\u5173\u952e\u56e0\u7d20\u3002<\/span><\/p>\n

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