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15px;\">\u6839\u636eFDA\u7684\u6a59\u76ae\u4e66\u4fe1\u606f\uff0c\u7d22\u62c9\u975e\u5c3c\u5728\u4e2d\u56fd\u7684\u5316\u5408\u7269\u4e13\u5229\uff08CN00802685.8\uff09\u6709\u6548\u671f\u622a\u81f32020\u5e741\u6708\uff0c\u800c\u5176\u7532\u82ef\u78fa\u9178\u76d0\u7684\u6676\u578b\u4e13\u5229\uff08CN200580040775.0\uff09\u7684\u6709\u6548\u671f\u622a\u81f32025\u5e749\u6708\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u6839\u636e\u62dc\u8033\u516c\u53f8\u7684\u5e74\u62a5\u4fe1\u606f\uff0c2017\u5e74\u7d22\u62c9\u975e\u5c3c\u7684\u9500\u552e\u989d\u4e3a8.34\u4ebf\u6b27\u5143\uff0c\u540c\u6bd4\u4e0b\u964d4.1%\u3002\u62dc\u8033\u516c\u53f8\u5c06\u7d22\u62c9\u975e\u5c3c\u9500\u552e\u989d\u7684\u964d\u4f4e\u5f52\u56e0\u4e8e\u9700\u6c42\u964d\u4f4e\u4e0e\u4ef7\u683c\u538b\u529b\u589e\u52a0\u3002\u6b64\u5916\uff0cMylan\u5236\u836f\u5df2\u7ecf\u4e8e2017\u5e74\u9488\u5bf9\u7d22\u62c9\u975e\u5c3c\u5728\u7f8e\u56fd\u7684\u4e13\u5229\u63d0\u51fa\u4e86\u4e13\u5229\u6311\u6218\uff0c\u5e76\u63d0\u51fa\u4e86ANDA\u7533\u8bf7\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u6839\u636e\u4e2d\u56fd\u533b\u836f\u5de5\u4e1a\u4fe1\u606f\u4e2d\u5fc3PDB\u836f\u7269\u7efc\u5408\u6570\u636e\u5e93\uff0c\u91cd\u70b9\u57ce\u5e02\u6837\u672c\u533b\u9662\u5185\u7d22\u62c9\u975e\u5c3c\u7684\u7528\u836f\u91d1\u989d\u5982\u4e0b\u56fe\u6240\u793a\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537166757.png\" alt=\"\u809d\u7ec6\u80de\u764c\u836f\u7269\u6cbb\u7597\u73b0\u72b6\u4e0e\u524d\u666f\" title=\"\u809d\u7ec6\u80de\u764c\u836f\u7269\u6cbb\u7597\u73b0\u72b6\u4e0e\u524d\u666f\"  \/><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: center;font-size: 14px;line-height: 2em;\"><span style=\"caret-color: red;font-size: 15px;\">\u6837\u672c\u533b\u9662\u5185\u7d22\u62c9\u975e\u5c3c\u7528\u836f\u91d1\u989d<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\uff082\uff09\u4e50\u4f10\u66ff\u5c3c<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u4e50\u4f10\u66ff\u5c3c\u662f\u7531\u536b\u6750\u516c\u53f8\u5f00\u53d1\u7684\u65b0\u578b\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5176\u4f5c\u7528\u9776\u70b9\u5305\u62ecVEGFR 1~3\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08FGFR 1~4\uff09\u3001PDGFR\u03b1\u4e0eRET\u3002FDA\u5148\u4e8e2015\u5e742\u6708\u6279\u51c6\u4e50\u4f10\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u3001\u8fdb\u5c55\u6027\u3001\u653e\u5c04\u6027\u7898\u96be\u6cbb\u6027\u7684\u5206\u5316\u578b\u7532\u72b6\u817a\u764c\uff0c\u800c\u540e\u53c8\u4e8e2016\u5e745\u6708\u6279\u51c6\u5176\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\uff0c\u7528\u4e8e\u6cbb\u7597\u5148\u524d\u63a5\u53d7\u8fc7\u6297\u8840\u7ba1\u751f\u6210\u7597\u6cd5\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">FDA\u6b64\u6b21\u6279\u51c6\u4e50\u4f10\u66ff\u5c3c\u6269\u5927\u9002\u5e94\u8bc1\u7684\u51b3\u5b9a\uff0c\u7cfb\u4ee5REFLECT\u4e34\u5e8a\u8bd5\u9a8c\uff08304\u53f7\u7814\u7a76\uff09\u7684\u6570\u636e\u4e3a\u57fa\u7840\uff0c\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u5148\u524d\u672a\u63a5\u53d7\u6cbb\u7597\u7684\u4e14\u4e0d\u53ef\u624b\u672f\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\u4e3a\u5bf9\u8c61\uff0c\u7ed3\u679c\u8bc1\u5b9e\u4e50\u4f10\u66ff\u5c3c\u7528\u836f\u60a3\u8005\u7684\u603b\u751f\u5b58\u65f6\u95f4\uff08OS\uff09\u975e\u52a3\u4e8e\u7d22\u62c9\u975e\u5c3c\uff0c\u800c\u524d\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\uff08PFS\uff09\u4e0e\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u5219\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5730\u4f18\u4e8e\u7d22\u62c9\u975e\u5c3c\uff0c\u4ece\u800c\u8fbe\u5230\u4e86\u4e34\u5e8a\u7ec8\u70b9\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u5177\u4f53\u7684\uff0cREFLECT\u8bd5\u9a8c\u7684\u7ed3\u679c\u663e\u793a\uff0c\u4e50\u4f10\u66ff\u5c3c\u7ec4\u4e0e\u7d22\u62c9\u975e\u5c3c\u7ec4\u7684OS\u5206\u522b\u4e3a13.6\u4e2a\u6708\u4e0e12.3\u4e2a\u6708\uff08HR=0.92\uff1b95%CI\uff1a0.79~1.06\uff09\uff0c\u5230\u8fbe\u4e86\u975e\u52a3\u6027\u7684\u4e34\u5e8a\u7ec8\u70b9\u3002\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6b21\u7ea7\u7ec8\u70b9\u6307\u6807\u7ed3\u679c\u5982\u4e0b\u8868\u6240\u793a\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537166757.png\" alt=\"\u809d\u7ec6\u80de\u764c\u836f\u7269\u6cbb\u7597\u73b0\u72b6\u4e0e\u524d\u666f\" title=\"\u809d\u7ec6\u80de\u764c\u836f\u7269\u6cbb\u7597\u73b0\u72b6\u4e0e\u524d\u666f\"  \/><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">REFLECT\u8bd5\u9a8c\u4e2d\uff0c\u4e50\u4f10\u66ff\u5c3c\u7ec4\u89c2\u5bdf\u5230\u7684\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u226520%\uff09\u5305\u62ec\u9ad8\u8840\u538b\u3001\u75b2\u52b3\u3001\u8179\u6cfb\u3001\u98df\u6b32\u964d\u4f4e\u3001\u638c\u8dd6\u7ea2\u611f\u89c9\u969c\u788d\u7efc\u5408\u5f81\u3001\u86cb\u767d\u5c3f\u3001\u53d1\u58f0\u969c\u788d\u3001\u5173\u8282\u75db\/\u808c\u75db\u3001\u9ad8\u8840\u538b\u3001\u4f53\u91cd\u964d\u4f4e\u3001\u51fa\u8840\u4e8b\u4ef6\u3001\u7532\u72b6\u817a\u529f\u80fd\u4f4e\u4e0b\u4e0e\u6076\u5fc3\uff1b\u6700\u5e38\u89c1\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff08\u22652%\uff09\u5305\u62ec\u809d\u8111\u75c5\uff085%\uff09\u3001\u8179\u6c34\uff083%\uff09\u4e0e\u98df\u6b32\u964d\u4f4e\uff082%\uff09\u3002\u7d22\u62c9\u975e\u5c3c\u7ec4\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u226520%\uff09\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u638c\u8dd6\u7ea2\u611f\u89c9\u969c\u788d\u7efc\u5408\u5f81\u3001\u8179\u6cfb\u3001\u75b2\u52b3\u3001\u9ad8\u8840\u538b\u3001\u8179\u75db\u3001\u98df\u6b32\u964d\u4f4e\u3001\u76ae\u80a4\u3001\u4f53\u91cd\u964d\u4f4e\u4e0e\u5173\u8282\u75db\/\u808c\u75db\uff1b\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u22652%\uff09\u5305\u62ec\u8179\u6c34\uff082%\uff09\u4e0e\u8179\u75db\uff082%\uff09\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u53e6\u636e\u8def\u900f\u793e\u7684\u6d88\u606f\uff0c\u536b\u6750\u516c\u53f8\u4e8e\u5f53\u5730\u65f6\u95f48\u670818\u65e5\u5c06\u4e50\u4f10\u66ff\u5c3c\u7684\u4ef7\u683c\u5b9a\u4e3a1.7\u4e07\u7f8e\u5143\/\u6708\uff0c\u800c\u6b64\u524d\u7684\u5b9a\u4ef7\u4e3a1.36\u4e07\u7f8e\u5143\/\u6708\uff088mg\u300110mg\u4e0e14mg\uff09\u4e0e1.47\u4e07\u7f8e\u5143\/\u6708\uff0818mg\u300120mg\u4e0e24mg\uff09\u3002\u8def\u900f\u793e\u8fd8\u8868\u793a\uff0c\u4e50\u4f10\u66ff\u5c3c\u6709\u671b\u4e8e2022\u5e74\u5b9e\u73b034.6\u4ebf\u7f8e\u5143\u7684\u9500\u552e\u989d\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u4e50\u4f10\u66ff\u5c3c\u5728\u4e2d\u56fd\u5df2\u7ecf\u8fdb\u5165\u4e0a\u5e02\u7533\u8bf7\u9636\u6bb5\uff08JXHS1700042\uff09\uff0c\u4e14\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u6709\u671b\u4e8e\u83b7\u51c6\u4e0a\u5e02\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u4e50\u4f10\u66ff\u5c3c\u5728\u4e2d\u56fd\u7533\u8bf7\u7684\u5316\u5408\u7269\u4e13\u5229\uff08CN01819710.8\uff09\u5df2\u6388\u6743\uff0c\u5c06\u4e8e2021\u5e7410\u6708\u5c4a\u6ee1\uff0c\u4f46\u5176\u7532\u78fa\u9178\u76d0\u6676\u578b\u4e13\u5229\uff08CN200480036184.1\uff09\u7684\u6709\u6548\u671f\u622a\u81f32024\u5e7412\u6708\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\uff083\uff09\u5176\u4ed6\u7597\u6cd5<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u6570\u9879\u7814\u7a76\u8bc4\u4ef7\u4e86\u591a\u79cd\u5176\u4ed6\u836f\u7269\u5355\u72ec\u7528\u836f\uff08\u5982\u8d1d\u4f10\u73e0\u5355\u6297\u3001\u8212\u5c3c\u66ff\u5c3c\u4e0ebrivanib\uff09\u6216\u8054\u5408\u7d22\u62c9\u975e\u5c3c\uff08\u591a\u67d4\u6bd4\u661f\u3001\u5384\u6d1b\u66ff\u5c3c\uff09\u5728HCC\u4e00\u7ebf\u6cbb\u7597\u4e2d\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\uff0c\u4f46\u4e0d\u5e78\u7684\u662f\uff0c\u6240\u6709\u836f\u7269\u5bf9\u60a3\u8005\u751f\u5b58\u60c5\u51b5\u7684\u6539\u5584\u6548\u679c\u5747\u4e0d\u53ca\u7d22\u62c9\u975e\u5c3c\u5355\u72ec\u7528\u836f\u7684\u6548\u679c\u3002\u5176\u4e2d\uff0c\u4e00\u9879\u5355\u7ec4\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u6297VEGF\u7684\u5355\u514b\u9686\u6297\u4f53\u8d1d\u4f10\u73e0\u5355\u6297\u4ee55mg\/kg\u621610mg\/kg\u7684\u5242\u91cf\u6bcf\u4e24\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u5176\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e0e\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\uff08PFS\uff09\u5206\u522b\u4e3a13%\u4e0e6.9\u4e2a\u6708\uff1b\u4e00\u9879\u2162\u671f\u3001\u968f\u673a\u5316\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u53cc\u76f2\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u5728\u7d22\u62c9\u975e\u5c3c\u7684\u57fa\u7840\u4e0a\u6dfb\u52a0\u5384\u6d1b\u66ff\u5c3c\u6cbb\u7597\uff0c\u5e76\u4e0d\u80fd\u6539\u5584HCC\u60a3\u8005\u7684\u751f\u5b58\u60c5\u51b5\uff0c\u5177\u4f53\u7684\uff0c\u5384\u6d1b\u66ff\u5c3c\u8054\u5408\u7d22\u62c9\u975e\u5c3c\u4e0e\u5355\u7528\u7d22\u62c9\u975e\u5c3c\u7684OS\u4e2d\u4f4d\u503c\u5206\u522b\u4e3a9.5\u4e2a\u6708\u4e0e8.5\u4e2a\u6708\uff08HR=0.929\uff1bP=0.408\uff09\uff1b\u4e00\u9879\u7eb3\u5165\u4e861073\u540d\u5148\u524d\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u665a\u671fHCC\u60a3\u8005\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u8212\u5c3c\u66ff\u5c3c\u7ec4\u7684\u751f\u5b58\u60c5\u51b5\u52a3\u4e8e\u7d22\u62c9\u975e\u5c3c\u7ec4\uff087.9\u4e2a\u6708vs 10.2\u4e2a\u6708\uff09\uff0c\u800c\u4e14\u4f1a\u663e\u8457\u52a0\u5267\u4e0d\u826f\u53cd\u5e94\u3002\u5316\u7597\u5728\u665a\u671fHCC\u6cbb\u7597\u4e2d\u7684\u6548\u76ca\u5c1a\u4e0d\u660e\u4e86\uff0c\u5176\u4e2d\u591a\u67d4\u6bd4\u661f\u662f\u6700\u5e38\u7528\u7684\u5316\u7597\u836f\u7269\u4e4b\u4e00\uff0c\u5176\u7f13\u89e3\u7387\u572820%\u5de6\u53f3\u3002\u7136\u800c\uff0c\u2162\u671f\u7684CALGB\u5374\u672a\u80fd\u8bc1\u5b9e\u591a\u67d4\u6bd4\u661f\u8054\u5408\u7d22\u62c9\u975e\u5c3c\u7684\u6548\u679c\u4f18\u4e8e\u5355\u7528\u7d22\u62c9\u975e\u5c3c\u7684\u6548\u679c\uff0c\u518d\u8005\u7684OS\u4e2d\u4f4d\u503c\u5206\u522b\u4e3a10.5\u4e2a\u6708\u4e0e9\u4e2a\u6708\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section class=\"_135editor\"   style=\"white-space: normal;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;font-size: 12px;max-width: 100%;color: rgb(62, 62, 62);height: 32px;border-bottom: 1px solid rgb(227, 227, 227);line-height: 18px;word-wrap: break-word !important;box-sizing: border-box !important;\"><strong class=\"135brush\"  style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;border-bottom: 2px solid rgb(0, 0, 0);border-top-color: rgb(0, 0, 0);border-right-color: rgb(0, 0, 0);border-left-color: rgb(0, 0, 0);color: rgb(0, 0, 0);display: block;float: left;font-size: 16px;line-height: 28px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e8c\u7ebf\u6cbb\u7597<\/strong><\/p>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\uff081\uff09\u9776\u5411\u6cbb\u7597<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u957f\u671f\u4ee5\u6765\uff0c\u7d22\u62c9\u975e\u5c3c\u662f\u665a\u671fHCC\u6cbb\u7597\u7684\u552f\u4e00\u836f\u7269\uff0c\u4f46\u4e00\u65e6\u60a3\u8005\u75c5\u60c5\u51fa\u73b0\u8fdb\u5c55\uff0c\u6216\u5bf9\u7d22\u62c9\u975e\u5c3c\u51fa\u73b0\u4e0d\u8010\u53d7\u6027\uff0c\u533b\u5e08\u5219\u5f80\u5f80\u62ff\u4e0d\u51fa\u6807\u51c6\u7684\u6cbb\u7597\u65b9\u6848\u3002\u5316\u7597\u867d\u7136\u5728HCC\u4e8c\u7ebf\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\u5c1a\u4e0d\u660e\u4e86\uff0c\u4f46\u4ecd\u7136\u662f\u533b\u5e08\u4e0d\u5f97\u4e0d\u5c1d\u8bd5\u7684\u6cbb\u7597\u65b9\u6848\u4e4b\u4e00\uff0c\u8fd9\u79cd\u60c5\u51b5\u4e00\u76f4\u5230FDA\u6279\u51c6\u745e\u6208\u975e\u5c3c\u4e0e\u7eb3\u6b66\u5355\u6297\u7528\u4e8e\u63a5\u53d7\u7d22\u62c9\u975e\u5c3c\u540e\u75c5\u60c5\u8fdb\u5c55\u7684\u60a3\u8005\u7684\u4e8c\u7ebf\u7597\u6cd5\u65f6\uff0c\u624d\u6709\u6240\u6539\u89c2\u3002\u4e00\u9879\u2162\u671f\u968f\u673a\u5316\u7684CELESTIAL\u8bd5\u9a8c\u8bc1\u5b9e\u4e86Cabozantinib\u7684\u6574\u4f53\u751f\u5b58\u6548\u76ca\uff0cREACH-2\u8bd5\u9a8c\u8bc1\u5b9e\u4e86Ramucirumab\u5bf9\u4f34\u6709\u7532\u80ce\u86cb\u767d\u6c34\u5e73\u5347\u9ad8\u7684HCC\u60a3\u8005\u7684\u6574\u4f53\u751f\u5b58\u6548\u76ca\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u2460&nbsp; &nbsp;\u745e\u6208\u975e\u5c3c<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u745e\u6208\u975e\u5c3c\u662f\u7531\u62dc\u8033\u516c\u53f8\u5f00\u53d1\u7684\u4e00\u79cd\u8840\u7ba1\u6e90\u6027VEGF 1~3\u3001\u7624\u539f\u6027\u4e0e\u57fa\u8d28\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u6700\u65e9\u4e8e2012\u5e749\u6708\u83b7FDA\u6279\u51c6\u7528\u4e8e\u8f6c\u79fb\u6027\u7ed3\u80a0\u764c\u7684\u4e8c\u7ebf\u6cbb\u7597\u30022017\u5e744\u6708\uff0cFDA\u4ee5\u2162\u671f\u3001\u968f\u673a\u5316\u3001\u53cc\u76f2\u4e0e\u5b89\u6170\u5242\u5bf9\u7167\u7684RESORCE\u8bd5\u9a8c\u4e3a\u4f9d\u636e\uff0c\u6279\u51c6\u745e\u6208\u975e\u5c3c\u7528\u4e8eHCC\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002RESORCE\u7eb3\u5165\u7684\u60a3\u8005\u5747\u5bf9\u7d22\u62c9\u975e\u5c3c\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff08\u505c\u836f\u524d28\u5929\u91c7\u7528\u2265400mg\/d\u7684\u5242\u91cf\u81f3\u5c11\u6cbb\u759720\u5929\uff09\uff0c\u800c\u4e14\u809d\u529f\u80fd\u5747\u4e3aChild-Pugh A\u7ea7\u3002\u5171\u6709573\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u968f\u673a\u5316\u5206\u7ec4\u4e0e\u6cbb\u7597\uff0c\u5176\u4e2d\uff0c\u745e\u6208\u975e\u5c3c\u7ec4\u7684OS\u503c\u663e\u8457\u4f18\u4e8e\u5b89\u6170\u5242\u7ec4\uff0810.6\u4e2a\u6708vs 7.8\u4e2a\u6708\uff1bHR=0.63\uff1b95%CI\uff1a0.50~0.79\uff1bP&lt;0.0001\uff09\u3002\u745e\u6208\u975e\u5c3c\u7ec4\u6700\u5e38\u89c1\u76843\u7ea7\u62164\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u9ad8\u8840\u538b\u3001\u624b-\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u75b2\u52b3\u4e0e\u8179\u6cfb\u3002\u7531\u4e8e\u8be5\u9879\u7814\u7a76\u4ec5\u7eb3\u5165\u4e86\u91c7\u7528\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u65f6\u75c5\u60c5\u51fa\u73b0\u8fdb\u5c55\uff0c\u800c\u4e14\u5bf9\u7d22\u62c9\u975e\u5c3c\u7684\u8010\u53d7\u6027\u4e5f\u6709\u8981\u6c42\uff0c\u56e0\u6b64\uff0c\u745e\u6208\u975e\u5c3c\u7528\u4e8e\u5bf9\u7d22\u62c9\u975e\u5c3c\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u65f6\u662f\u5426\u6709\u6548\u5c1a\u65e0\u5b9a\u8bba\u3002\u6b64\u5916\uff0c\u8be5\u9879\u8bd5\u9a8c\u8fd8\u8868\u660e\uff0c\u5982\u679c\u5728\u5bf9\u4e0d\u826f\u53cd\u5e94\u4e88\u4ee5\u6709\u6548\u63a7\u5236\u7684\u540c\u65f6\uff0c\u6309\u987a\u5e8f\u91c7\u7528\u591a\u6fc0\u9176\u6291\u5236\u5242\u8fdb\u884c\u6cbb\u7597\uff0c\u5c06\u6709\u52a9\u4e8e\u5ef6\u957f\u60a3\u8005\u7684\u751f\u5b58\u65f6\u95f4\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u745e\u6208\u975e\u5c3c\u5728\u4e2d\u56fd\u7533\u8bf7\u7684\u5316\u5408\u7269\u4e13\u5229CN200480021091.1\u5df2\u83b7\u6388\u6743\uff0c\u5176\u6709\u6548\u671f\u622a\u81f32024\u5e747\u6708\uff1b\u745e\u6208\u975e\u5c3c\u4ee5\u4e00\u6c34\u5408\u7269\u4f9b\u836f\u7528\uff0c\u5176\u6676\u578b\u7684\u4e2d\u56fd\u4e13\u5229CN200780037680.2\u4e5f\u5df2\u83b7\u6388\u6743\uff0c\u6709\u6548\u671f\u622a\u6b622027\u5e749\u6708\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u6839\u636e\u62dc\u8033\u516c\u53f8\u7684\u5e74\u62a5\u4fe1\u606f\uff0c2017\u5e74\u745e\u6208\u975e\u5c3c\u7684\u9500\u552e\u989d\u4e3a3.15\u4ebf\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957f14.5%\u3002\u7531\u4e8e\u745e\u6208\u975e\u5c3c\u4e8e2017\u5e744\u6708\u624d\u83b7\u51c6\u7528\u4e8eHCC\u7684\u4e8c\u7ebf\u6cbb\u7597\uff0c\u56e0\u6b64\u5176\u9500\u552e\u989d\u4e3b\u8981\u7531\u7ed3\u80a0\u764c\u4e0e\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u6240\u8d21\u732e\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u2461&nbsp; Cabozantinib<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">Cabozantinib\u662f\u7531Exelixis\u516c\u53f8\u5f00\u53d1\u7684\u4e00\u79cdMET\u3001VEGFR\u4e0eAXL\u6291\u5236\u5242\uff0c\u5df2\u83b7FDA\u6279\u51c6\u7684\u9002\u5e94\u8bc1\u5305\u62ec\u7532\u72b6\u817a\u9ad3\u6837\u764c\u3001\u80be\u7ec6\u80de\u764c\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">CELESTIAL\u8bd5\u9a8c\u5219\u4ee5\u5b89\u6170\u5242\u4e3a\u5bf9\u7167\uff0c\u8bc4\u4ef7\u4e86\u8be5\u836f\u5bf9\u5148\u524d\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u665a\u671fHCC\u60a3\u8005\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\uff0c\u800c\u4e0eRESORCE\u8bd5\u9a8c\u4e0d\u540c\u7684\u662f\uff0cCELESTIAL\u5e76\u4e0d\u8981\u6c42\u53d7\u8bd5\u8005\u5bf9\u7d22\u62c9\u975e\u5c3c\u8010\u53d7\u3002\u5171\u6709707\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u968f\u673a\u5316\u5206\u7ec4\u4e0e\u6cbb\u7597\uff0cCabozantinib\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u7684OS\u4e2d\u4f4d\u503c\u5206\u522b\u4e3a10.2\u4e2a\u6708\u4e0e8.0\u4e2a\u6708\uff08HR=0.76\uff1b95%CI\uff1a0.63~0.92\uff1bP=0.0049\uff09\uff0c\u4e24\u7ec4\u7684PFS\u4e2d\u4f4d\u503c\u5206\u522b\u4e3a5.2\u4e2a\u6708\u4e0e1.9\u4e2a\u6708\uff08HR=0.44\uff1b95%CI\uff1a0.36~0.52\uff1bP&lt;0.0001\uff09\uff0cCabozantinib\u7684\u8fd9\u4e24\u4e2a\u6307\u6807\u5747\u663e\u8457\u4f18\u4e8e\u5b89\u6170\u5242\u7ec4\u3002Cabozantinib vs \u5b89\u6170\u5242\u7ec4\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u624b-\u8db3\u76ae\u80a4\u53cd\u5e94\uff0817% vs 0%\uff09\u3001\u9ad8\u8840\u538b\uff0816% vs 2%\uff09\u3001\u5929\u51ac\u6c28\u9178\u8f6c\u6c28\u9176\u6c34\u5e73\u4e0a\u5347\uff0812% vs 7%\uff09\u3001\u75b2\u52b3\uff0810% vs 4%\uff09\u4e0e\u8179\u6cfb\uff0810% vs 2%\uff09\u3002\u7531\u4e8e\u5176\u6539\u5584OS\u4e0ePFS\u7684\u6548\u679c\u663e\u8457\uff0cCabozantinib\u6709\u671b\u83b7FDA\u6279\u51c6\u7528\u4e8eHCC\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">FDA\u6a59\u76ae\u4e66\u4e2d\u6536\u5f55\u7684Cabozantinib\u5316\u5408\u7269\u4e13\u5229US7579473\u672a\u8fdb\u5165\u4e2d\u56fd\uff1bCabozantinib\u836f\u7528\u5176S-\u82f9\u679c\u9178\u76d0\uff0c\u4f46\u6a59\u76ae\u4e66\u4e2d\u672a\u6536\u5f55\u6676\u578b\u4e13\u5229\uff0c\u800c\u5305\u542b\u5176S-\u82f9\u679c\u9178\u76d0\u7684\u7ec4\u5408\u7269\u7684\u4e2d\u56fd\u4e13\u5229\u539f\u6848\u7533\u8bf7CN201180044602.1\u5c1a\u5728\u5ba1\u67e5\u9636\u6bb5\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u6839\u636eExelixis\u7684\u5e74\u62a5\u4fe1\u606f\uff0c2017\u5e74Cabozantinib\u7684\u5168\u7403\u9500\u552e\u989d\u4e3a3.49\u4ebf\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957f158%\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u2462 Ramucirumab<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">Ramucirumab\u662f\u4e00\u79cd\u4e0eVEGFR-2\u53d7\u4f53\u7ed3\u5408\u5e76\u963b\u65ad\u540e\u8005\u6d3b\u5316\u7684\u5355\u514b\u9686\u6297\u4f53\u3002\u8d77\u521d\u4e00\u9879\u7eb3\u516542\u540d\u5148\u524d\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u6cbb\u7597\u7684\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cRamucirumab\u7684ORR\u4e0eOS\u4e2d\u503c\u5206\u522b\u4e3a10%\u4e0e12\u4e2a\u6708\uff0c\u63d0\u793a\u8be5\u836f\u53ef\u4ea7\u751f\u4e2d\u5ea6\u7684\u6cbb\u7597\u6d3b\u6027\u3002\u4e00\u9879\u540d\u4e3aREACH\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6bd4\u8f83\u4e86Ramucirumab\u4e0e\u5b89\u6170\u5242\u5bf9\u5148\u524d\u91c7\u7528\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u665a\u671fHCC\u60a3\u8005\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\uff0c\u4e24\u8005\u7684OS\u4e2d\u4f4d\u503c\u5206\u522b\u4e3a9.2\u4e2a\u6708\u4e0e7.6\u4e2a\u6708\uff0cRamucirumab\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5e76\u65e0\u663e\u8457\u7684\u4f18\u52bf\u3002\u4f46\u968f\u540e\u7684\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0cRamucirumab\u5bf9\u786e\u8bca\u65f6\u7532\u80ce\u86cb\u767d&gt;400ng\/mL\u7684\u60a3\u8005\u7684\u6548\u76ca\u4f18\u4e8e\u5b89\u6170\u5242\u3002\u968f\u540e\u7684REACH-2\u8bd5\u9a8c\u5219\u7eb3\u5165\u4e86292\u540d\u57fa\u7ebf\u7532\u80ce\u86cb\u767d\u5347\u9ad8\u4e14\u91c7\u7528\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u6216\u5bf9\u7d22\u62c9\u975e\u5c3c\u4e0d\u8010\u53d7\u7684HCC\u60a3\u8005\uff0c\u8be5\u8bd5\u9a8c\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cRamucirumab\u53ef\u663e\u8457\u6539\u5584\u60a3\u8005\u7684OS\uff088.5\u4e2a\u6708vs 7.3\u4e2a\uff0cP=0.01999\uff09\u3001PFS\uff082.8\u4e2a\u6708 vs 1.6\u4e2a\u6708\uff0cP&lt;0.0001\uff09\u4e0e\u75be\u75c5\u63a7\u5236\u7387\uff0859.9% vs 38.9%\uff0cP=0.0006\uff09\u3002Ramucirumab\u7ec4\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u9ad8\u8840\u538b\u4e0e\u4f4e\u94a0\u8840\u75c7\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u2463 \u4f9d\u7ef4\u83ab\u53f8<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u4f9d\u7ef4\u83ab\u53f8\u662f\u54fa\u4e73\u52a8\u7269\u96f7\u5e15\u9709\u7d20\u9776\u5206\u5b50\uff08mTOR\uff09\u6291\u5236\u5242\uff0cmTOR\u662f\u7ec6\u80de\u751f\u957f\u4e0e\u8840\u7ba1\u751f\u6210\u91cd\u8981\u7684\u8c03\u63a7\u56e0\u7d20\uff0c\u800c\u8fd9\u4e00\u901a\u8def\u5728HCC\u60a3\u8005\u4e2d\u7684\u8868\u8fbe\u7387\u4e3a40%~50%\u3002\u4e00\u9879\u4ee5\u91c7\u7528\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u6216\u5bf9\u7d22\u62c9\u975e\u5c3c\u4e0d\u8010\u53d7\u7684HCC\u60a3\u8005\u4e3a\u5bf9\u8c61\u7684\u5927\u89c4\u6a21\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\uff0c\u4f9d\u7ef4\u83ab\u53f8\u4e0e\u5b89\u6170\u5242\u7684OS\u5206\u522b\u4e3a7.6\u4e2a\u6708\u4e0e7.3\u4e2a\u6708\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u2464 \u963f\u897f\u66ff\u5c3c<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u963f\u897f\u66ff\u5c3c\u662f\u4e00\u79cd\u4ee5VEGFRs\u4e3a\u9776\u70b9\u7684\u7b2c\u4e8c\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002\u4e00\u9879\u7eb3\u5165\u4e86202\u540d\u91c7\u7528\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u6216\u5bf9\u7d22\u62c9\u975e\u5c3c\u4e0d\u8010\u53d7\u7684\u665a\u671fHCC\u60a3\u8005\u5bf9\u963f\u897f\u66ff\u5c3c\u4e0e\u6700\u4f73\u652f\u6301\u6027\u62a4\u7406\u65b9\u6cd5\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u4e24\u8005\u7684OS\u4e2d\u4f4d\u503c\u5206\u522b\u4e3a12.7\u4e2a\u6708\u4e0e9.7\u4e2a\u6708\uff0c\u5176\u5dee\u5f02\u65e0\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u2465 Brivanib<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">Brivanib\u662f\u4ee5FGFR\u4e0eVEGFR\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u4e3a\u9776\u70b9\u7684\u9009\u62e9\u6027\u53cc\u91cd\u6291\u5236\u5242\uff0c\u5176\u4e2dFGF\u86cb\u767d\u53c2\u4e0eHCC\u7684\u80bf\u7624\u751f\u957f\u4e0e\u8840\u7ba1\u751f\u6210\u3002\u2162\u671f\u7684BRISK-PS\u8bd5\u9a8c\u4ee5\u5148\u524d\u91c7\u7528\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u4f46\u75c5\u60c5\u8fdb\u5c55\u6216\u5bf9\u7d22\u62c9\u975e\u5c3c\u4e0d\u8010\u53d7\u7684\u665a\u671fHCC\u60a3\u8005\u4e3a\u5bf9\u8c61\uff0c\u8bc4\u4ef7\u4e86Brivanib\u4e0e\u5b89\u6170\u5242\u4e86\u751f\u5b58\u6548\u76ca\u3002\u7ed3\u679c\u8868\u660e\uff0c\u518d\u8005\u7684OS\u4e2d\u4f4d\u503c\u5206\u522b\u4e3a9.4\u4e2a\u6708\u4e0e8.2\u4e2a\u6708\uff08HR\u2009=\u20090.89\uff1b95% CI\uff1a0.69~1.15\uff1bp\u2009=\u20090.3307\uff09\uff0c\u5176\u5dee\u5f02\u65e0\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\uff082\uff09\u514d\u75ab\u7597\u6cd5<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u5728\u53bb\u8fc7\u7684\u6570\u5e74\u5185\uff0c\u514d\u75ab\u7597\u6cd5\u7ed9\u80bf\u7624\u7684\u6cbb\u7597\u5e26\u6765\u4e86\u5de8\u5927\u7684\u53d8\u5316\uff0c\u5c31HCC\u9886\u57df\u800c\u8a00\uff0c\u79d1\u7814\u4eba\u5458\u6b63\u5728\u5bf9\u5305\u62ec\u80bf\u7624\u6297\u539f\u7597\u6cd5\u3001\u514d\u75ab\u5173\u5361\uff08immune checkpoint\uff09\u6291\u5236\u5242\u4e0e\u8fc7\u7ee7\u6027\u7ec6\u80de\u6cbb\u7597\uff08ACT\uff09\u5728\u5185\u7684\u591a\u79cd\u514d\u75ab\u7597\u6cd5\u8fdb\u884c\u7814\u7a76\uff0c\u800c\u4e14\u5df2\u6709\u591a\u4e2a\u514d\u75ab\u5173\u5361\u6291\u5236\u5242\u83b7FDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u6076\u6027\u80bf\u7624\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u2460&nbsp; \u514d\u75ab\u5173\u5361\u6291\u5236\u5242<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">HCC\u4e34\u5e8a\u8bd5\u9a8c\u6d89\u53ca\u7684\u514d\u75ab\u5173\u5361\u6291\u5236\u5242\u5305\u62ec\u7eb3\u6b66\u5355\u6297\u3001Pembrolizumab\u4e0eTremelimumab\u7b49\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u4e00\u9879\u7eb3\u5165262\u540dChild-Pugh A\u7ea7\u786c\u5316\u7684HCC\u60a3\u8005\u7684\u2160\/\u2161\u671f\u591a\u961f\u5217\u4e34\u5e8a\u8bd5\u9a8c\uff08checkmate 040\uff09\u5bf9\u514d\u75ab\u5173\u5361\u6291\u5236\u5242\u7eb3\u6b66\u5355\u6297\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5176\u53d7\u8bd5\u8005\u540c\u65f6\u5305\u62ec\u4e86\u5148\u524d\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u4e0e\u5148\u524d\u91c7\u7528\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u4f46\u75c5\u60c5\u8fdb\u5c55\u7684\u53d7\u8bd5\u8005\u3002\u8be5\u9879\u8bd5\u9a8c\u7684\u5242\u91cf\u722c\u5761\u671f\u786e\u8bc1\u4e863mg\/kg\u5242\u91cf\u4e0b\u7684\u5b89\u5168\u6027\uff0c\u56e0\u6b64\uff0c\u5728\u968f\u540e\u7684\u8bd5\u9a8c\u4e2d\uff0c\u7eb3\u6b66\u5355\u6297\u5373\u4ee53mg\/kg\u7684\u5242\u91cf\u6bcf\u4e24\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u800c\u65e0\u8bba\u60a3\u8005\u4e4b\u524d\u662f\u5426\u63a5\u53d7\u8fc7\u6cbb\u7597\uff0c\u7eb3\u6b66\u5355\u6297\u7684ORR\u5747\u572815%~20%\u4e4b\u95f4\u300269%\u7684\u5e94\u7b54\u8005\u57283\u4e2a\u6708\u5185\u5b9e\u73b0\u7f13\u89e3\u3002\u8be5\u9879\u8bd5\u9a8c\u8fd8\u663e\u793a\uff0c\u5b9e\u73b018\u4e2a\u6708OS\u7684\u53d7\u8bd5\u8005\u5728\u5148\u524d\u672a\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u4e0e\u5148\u524d\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u4e2d\u6240\u5360\u6bd4\u4f8b\u5206\u522b\u4e3a57%\u4e0e44%\uff0c\u800c\u4e14\u662f\u5426\u51fa\u73b0\u7f13\u89e3\u4e0eHCC\u75c5\u56e0\u6216\u80bf\u7624\u7ec6\u80de\u7a0b\u5e8f\u6027\u6b7b\u4ea1-\u914d\u4f531\uff08PD-L1\uff09\u7684\u8868\u8fbe\u60c5\u51b5\u65e0\u5173\u3002\u8be5\u9879\u8bd5\u9a8c\u4e2d\u7eb3\u6b66\u5355\u6297\u7684\u4e0d\u826f\u53cd\u5e94\u7279\u5f81\u4e0e\u5148\u524d\u5176\u4ed6\u8bd5\u9a8c\u7684\u60c5\u51b5\u76f8\u4f3c\uff0c\u4e3b\u8981\u662f\u8f6c\u6c28\u9176\u6c34\u5e73\u4e0e\u80c6\u7ea2\u7d20\u6c34\u5e73\u4e0a\u5347\uff0c\u53e6\u67095%\u7684\u60a3\u8005\u56e0\u4e3a\u51fa\u73b0\u514d\u75ab\u4ecb\u5bfc\u7684\u809d\u708e\u800c\u9700\u8981\u5168\u8eab\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u3002\u76ee\u524d\uff0c\u4e00\u9879\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8cNCT02576509\u6b63\u5728\u6bd4\u8f83\u7eb3\u6b66\u5355\u6297\u4e0e\u7d22\u62c9\u975e\u5c3c\u7528\u4e8e\u665a\u671fHCC\u4e00\u7ebf\u6cbb\u7597\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u4e00\u9879\u7eb3\u5165105\u540d\u53d7\u8bd5\u8005\u7684\u5355\u7ec4\u3001\u5f00\u653e\u6807\u7b7e\u7684\u2161\u671fKEYNOTE-244\u7814\u7a76\u8bc4\u4ef7\u4e86\u53e6\u4e00\u79cd\u5173\u5361\u6291\u5236\u5242Pembrolizumab\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\uff0c\u5176ORR\u503c\u4e3a16.3%\uff0895%CI\u4e3a9.8~24.9%\uff09\uff0c\u4e00\u540d\u60a3\u8005\u5b8c\u5168\u7f13\u89e3\u3002\u4e2d\u4f4dPFS\u4e3a4.8\u4e2a\u6708\uff0c\u4f46\u672a\u5230\u8fbe\u4e2d\u4f4dOS\u503c\u3002\u5b9e\u73b06\u4e2a\u6708PFS\u4e0eOS\u60a3\u8005\u6240\u5360\u6bd4\u4f8b\u5206\u522b\u4e3a43.1%\u4e0e77.9%<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">Tremelimumab\u4e5f\u662f\u4e00\u79cd\u5173\u5361\u6291\u5236\u5242\uff0c\u540c\u65f6\u8fd8\u662f\u4e00\u79cd\u6297\u7ec6\u80de\u6bd2\u6027T-\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u6027\u86cb\u767d4\uff08CTLA-4\uff09\u6297\u4f53\u3002\u4e00\u9879\u5148\u5bfc\u6027\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT01008358\uff09\u4ee5\u4f34\u6709HCV\u611f\u67d3\u7684HCC\u60a3\u8005\u4e3a\u5bf9\u8c61\uff0c\u5bf9Tremelimumab\u8fdb\u884c\u4e86\u8003\u5bdf\uff0c\u5176\u75be\u75c5\u63a7\u5236\u7387\u4e3a76.4%\uff0c\u75be\u75c5\u8fdb\u5c55\u65f6\u95f4\uff08TTP\uff09\u4e3a6.5\u4e2a\u6708\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u2461&nbsp; PD-L1\u6291\u5236\u5242<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">Atezolizumab\u662f\u4e00\u79cdPD-L1\u6291\u5236\u5242\uff0c\u4e00\u9879\u2160b\u671f\u8bd5\u9a8c\u4ee5\u5148\u524d\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u4e0d\u53ef\u624b\u672f\u7684\u6216\u8f6c\u79fb\u6027HCC\u60a3\u8005\u4e3a\u5bf9\u8c61\uff0c\u5bf9Atezolizumab\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u8054\u5408\u7528\u836f\u8fdb\u884c\u4e86\u8003\u5bdf\u3002\u60a3\u8005\u6bcf3\u5468\u7528Atezolizumab 1200mg\u4e0e\u8d1d\u4f10\u73e0\u5355\u629715mg\/kg\u6ce8\u5c04\u4e00\u6b21\uff0c\u76f4\u81f3\u75c5\u60c5\u51fa\u73b0\u8fdb\u5c55\uff0c\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f410.3\u4e2a\u6708\u540e\uff0c23\u540d\u53ef\u8bc4\u4ef7\u60a3\u8005\u7684ORR\u4e3a65%\u3002\u6700\u5e38\u89c1\u7684\u6cbb\u7597\u76f8\u5173\u60273~4\u7ea7\u4e0d\u826f\u53cd\u5e94\u662f\u9ad8\u8840\u538b\u3002FDA\u5bf9\u8fd9\u4e00\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u665a\u671f\u6216\u8f6c\u79fb\u6027HCC\u4e00\u7ebf\u6cbb\u7597\u7684\u9002\u5e94\u8bc1\u8ba4\u5b9a\u4e3a\u7a81\u7834\u6027\u7597\u6cd5\u3002\u4e00\u9879\u2162\u671fIMbrave150\uff08NCT03434379\uff09\u6b63\u5728\u6bd4\u8f83atezolizumab\/\u8d1d\u4f10\u73e0\u5355\u6297\u4e0e\u7d22\u62c9\u975e\u5c3c\u4e00\u7ebf\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027HCC\u60a3\u8005\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u2462&nbsp; CAR-T<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;padding-right: 10px;padding-left: 10px;white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08CAR-T\uff09\u5c5e\u4e8e\u4e00\u79cdACT\u514d\u75ab\u7597\u6cd5\uff0c\u5176\u5728\u96be\u6cbb\u6027\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7684\u6cbb\u7597\u4e2d\u5df2\u7ecf\u53d6\u5f97\u4e86\u5de8\u5927\u7684\u6210\u529f\uff0c\u5176\u4e2d\u6700\u4ee4\u4eba\u77a9\u76ee\u7684\u662fCAR-T\u5728\u6cbb\u7597B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\u4e2d\u7684\u5e94\u7528\u3002\u80bf\u7624\u7ec6\u80de\u8868\u9762\u8bb8\u591a\u8868\u8fbe\u5f02\u5e38\u7684\u86cb\u767d\/\u6297\u539f\u5747\u53ef\u7528\u4f5c\u57fa\u56e0\u5de5\u7a0bT\u7ec6\u80de\u9776\u5411\u80bf\u7624\u7ec6\u80de\u7684\u6807\u8bb0\u7269\u3002\u82e5CAR-T\u7597\u6cd5\u7684\u9002\u7528\u9886\u57df\u6269\u5c55\u81f3\u5b9e\u4f53\u80bf\u7624\uff0c\u5219\u80fd\u6781\u5927\u5730\u6539\u89c2\u5b9e\u4f53\u80bf\u7624\u7684\u6cbb\u7597\u73b0\u72b6\uff0c\u4f46\u4e5f\u9762\u4e34\u524d\u8bf8\u591a\u6311\u6218\uff0c\u5176\u4e2d\uff0c\u5982\u4f55\u7cbe\u786e\u8bc6\u522b\u9776\u70b9\u6297\u539f\u5e76\u8bbe\u8ba1\u5177\u6709\u9ad8\u9009\u62e9\u6027\u7684CARs\u5219\u662fCAR-T\u7597\u6cd5\u4e34\u5e8a\u5e94\u7528\u7684\u5173\u952e\u73af\u8282\u3002\u591a\u9879\u7814\u7a76\u6b63\u5728\u8003\u5bdfCAR-T\u7597\u6cd5\u5728HCC\u4e0e\u5176\u4ed6\u5b9e\u4f53\u80bf\u7624\u7684\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u524d\u666f\uff0c\u7532\u80ce\u86cb\u767d\uff08AFP\uff09\u5219\u662f\u80fd\u4f7fCAR-T\u7597\u6cd5\u6cbb\u7597HCC\u7684\u7279\u5f02\u6027\u9776\u70b9\u6297\u539f\u3002AFP\u662f\u4e00\u79cd\u5206\u6ccc\u578b\u7cd6\u86cb\u767d\uff0c\u5176\u901a\u5e38\u4f1a\u5728\u5305\u62ec\u513f\u79d1\u809d\u6bcd\u7ec6\u80de\u7624\u4e0eHCC\u5728\u5185\u7684\u5185\u80da\u6e90\u6027\u80bf\u7624\u4e2d\u5747\u6709\u8fc7\u5ea6\u8868\u8fbe\u7684\u73b0\u8c61\uff0c\u636e\u62a5\u9053\u8fd8\u4f1a\u4fc3\u8fdb\u7ec6\u80de\u589e\u6b96\u5e76\u6291\u5236\u7ec6\u80de\u51cb\u4ea1\uff0c\u4ece\u800c\u8bf4\u660e\u5176\u5728\u80bf\u7624\u8fdb\u5c55\u4e2d\u626e\u6f14\u7740\u4e00\u5b9a\u7684\u89d2\u8272\u3002\u5176\u4ed6\u53ef\u80fd\u4e0eHCC\u6709\u5173\u7684\u80bf\u7624\u76f8\u5173\u6027\u6297\u539f\uff08TAA\uff09\u5305\u62ecCEA\u3001 MUC1\u3001MAGE-A1\u3001NY-ESO-1\u3001\u4e0a\u76ae\u7ec6\u80de\u7c98\u9644\u5206\u5b50\uff08EPCAM\uff09\u4e0e\u70ed\u4f11\u514b\u86cb\u767d70\uff08HSP70\uff09\u3002\u867d\u7136CART-T\u7597\u6cd5\u7684\u5e94\u7528\u524d\u666f\u826f\u597d\uff0c\u4f46\u4e5f\u9762\u4e34\u7740\u8bf8\u591a\u7684\u969c\u788d\u3002\u5176\u4e2d\uff0cCAR-T\u7ec6\u80de\u5728\u80bf\u7624\u4f4d\u70b9\u7684\u5b9a\u4f4d\u4e0e\u7a7f\u900f\u4e0d\u5145\u5206\uff0c\u4ee5\u53ca\u5177\u6709\u514d\u75ab\u6291\u5236\u4f5c\u7528\u7684\u80bf\u7624\u5fae\u73af\u5883\u5bfc\u81f4CAR-T\u7597\u6cd5\u7684\u6709\u6548\u6027\u504f\u4f4e\uff0c\u6b64\u5916\uff0c\u7531\u4e8e\u7f3a\u4e4f\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\uff0cCAR-T\u7597\u6cd5\u4f1a\u5f15\u8d77\u4e00\u7cfb\u5217\u7684\u9776\u70b9\u5916\u6216\u80bf\u7624\u5916\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002\u6f5c\u5728\u7684\u4e25\u91cd\u7684\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u662f\u4e0eCAR-T\u76f8\u5173\u7684\u4e00\u79cd\u91cd\u5927\u6bd2\u6027\u53cd\u5e94\u3002CAR-T\u7684\u7279\u5f02\u6027\u53ef\u901a\u8fc7\u53cc\u7279\u5f02\u6027\u7684\u4e32\u8054CAR-T\u4e88\u4ee5\u589e\u5f3a\uff0c\u800c\u5176\u5728\u5b9e\u4f53\u80bf\u7624\u4e2d\u7684\u5b9a\u4f4d\u4e0e\u6d78\u6da6\u6548\u679c\u53ef\u901a\u8fc7\u8868\u8fbe\u8d8b\u5316\u56e0\u5b50\u53d7\u4f532\uff08CCR2\uff09\u578b\u7b49\u529f\u80fd\u6027\u8d8b\u52bf\u5316\u56e0\u5b50\u53d7\u4f53\u800c\u5f97\u4ee5\u589e\u5f3a\u3002\u6b64\u5916\uff0c\u91c7\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4e0etocilizumab 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