{"id":40791,"date":"2018-08-21T01:00:00","date_gmt":"2018-09-17T06:46:22","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e8%af%ba%e5%92%8c%e8%af%ba%e5%be%b7%e5%8f%a3%e6%9c%8dsemaglutide%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e5%8f%96%e5%be%97%e5%8f%88%e4%b8%80%e7%aa%81%e7%a0%b4%ef%bc%81\/"},"modified":"2018-09-17T14:46:23","modified_gmt":"2018-09-17T06:46:23","slug":"%e8%af%ba%e5%92%8c%e8%af%ba%e5%be%b7%e5%8f%a3%e6%9c%8dsemaglutide%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e5%8f%96%e5%be%97%e5%8f%88%e4%b8%80%e7%aa%81%e7%a0%b4%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/40791\/","title":{"rendered":"\u8bfa\u548c\u8bfa\u5fb7\u53e3\u670dSemaglutide\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u53c8\u4e00\u7a81\u7834\uff01"},"content":{"rendered":"
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\u7cd6\u5c3f\u75c5\u5de8\u5934\u8bfa\u548c\u8bfa\u5fb7\u4e8e\u5f53\u5730\u65f6\u95f48\u670820\u65e5\u53d1\u5e03\u6d88\u606f\u79f0\uff0c\u6700\u8fd1\u5b8c\u6210\u7684\u4e00\u98793a\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08PIONEER 5\uff09\u7ed3\u679c\u663e\u793a\uff0c\u53e3\u670dSemaglutide\u5bf9\u4f34\u968f\u6709\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684HbA1c\u6c34\u5e73\u4e0e\u4f53\u91cd\u7684\u6539\u5584\u6548\u679c\u5747\u663e\u8457\u4f18\u4e8e\u5b89\u6170\u5242\u3002<\/span><\/span>
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 \u5168\u65874278\u5b57\uff0c\u7528\u65f68\u5206\u949f<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4f5c\u8005\uff1a\u5411\u98de<\/span><\/p>\n

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\u7cd6\u5c3f\u75c5\u5de8\u5934\u8bfa\u548c\u8bfa\u5fb7\u4e8e\u5f53\u5730\u65f6\u95f42018\u5e748\u670820\u65e5\u53d1\u5e03\u6d88\u606f\u79f0\uff0c\u6700\u8fd1\u5b8c\u6210\u7684\u4e00\u98793a\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08PIONEER 5\uff09\u7ed3\u679c\u663e\u793a\uff0c\u53e3\u670dSemaglutide\u5bf9\u4f34\u968f\u6709\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684HbA1c\u6c34\u5e73\u4e0e\u4f53\u91cd\u7684\u6539\u5584\u6548\u679c\u5747\u663e\u8457\u4f18\u4e8e\u5b89\u6170\u5242\u3002<\/span><\/p>\n

PIONEER 5\u8bd5\u9a8c\u4e3a\u671f26\u5468\uff0c\u4ee5\u5148\u524d\u91c7\u7528\u4e8c\u7532\u53cc\u80cd\u3001\u78fa\u9170\u8132\u3001\u4e8c\u7532\u53cc\u80cd\u8054\u5408\u78fa\u9170\u8132\u3001\u57fa\u7840\u80f0\u5c9b\u7d20\u6216\u57fa\u7840\u80f0\u5c9b\u7d20\u8054\u5408\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u4f46\u75c5\u60c5\u672a\u83b7\u6709\u6548\u63a7\u5236\uff0c\u800c\u4e14\u4f34\u6709\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u7684324\u540d2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e3a\u7814\u7a76\u5bf9\u8c61\uff0c\u6bd4\u8f83\u4e86\u53e3\u670dSemaglutide\uff0814mg qd\uff09\u4e0e\u5b89\u6170\u5242\u5728\u63a7\u5236\u8840\u7cd6\u4e0e\u63a7\u5236\u4f53\u91cd\u65b9\u9762\u7684\u6548\u679c\u3002\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u91c7\u7528\u4e86\u4e24\u79cd\u622a\u7136\u4e0d\u540c\u7684\u7edf\u8ba1\u5b66\u65b9\u6cd5\uff1a\u4e3b\u8981\u7684\u7edf\u8ba1\u5b66\u65b9\u6cd5\u662f\u6839\u636e\u6700\u65b0\u7684\u76f8\u5173\u6307\u5357\u6240\u8981\u6c42\u7684\uff0c\u6240\u9002\u7528\u7684\u4eba\u7fa4\u5305\u62ec\u4e86\u5df2\u7ecf\u505c\u836f\u4e0e\u5c1a\u5728\u63a5\u53d7\u6cbb\u7597\u60a3\u8005\uff0c\u4ee5\u53ca\u4f7f\u7528\u4e86\u4e0e\u672a\u4f7f\u7528\u8865\u6551\u836f\u7269\u7684\u60a3\u8005\uff1b\u800c\u6b21\u8981\u7684\u7edf\u8ba1\u5b66\u65b9\u6cd5\u5219\u4e3b\u8981\u8bc4\u4ef7\u5c1a\u5728\u63a5\u53d7\u6cbb\u7597\u800c\u4e14\u672a\u4f7f\u7528\u8865\u6551\u836f\u7269\u7684\u60a3\u8005\u3002<\/span><\/p>\n

PIONEER 5\u8bd5\u9a8c\u663e\u793a\uff0c\u53e3\u670dsemaglutide\u5728\u4f34\u6709\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5176\u8010\u53d7\u6027\u7279\u5f81\u4e0e\u5176\u4ed6GLP-1\u7684\u60c5\u51b5\u4e00\u81f4\uff0c\u5176\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u6076\u5fc3\uff0c\u8be5\u4e0d\u826f\u53cd\u5e94\u5728\u53e3\u670dsemaglutide\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u7684\u53d1\u75c5\u7387\u5206\u522b\u4e3a19%\u4e0e8%\u3002\u4e24\u7ec4\u5206\u522b\u670915%\u4e0e6%\u7684\u53d7\u8bd5\u8005\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u800c\u505c\u6b62\u6cbb\u7597\u3002<\/span><\/p>\n

\u8bfa\u548c\u8bfa\u5fb7\u7684\u6267\u884c\u526f\u603b\u88c1\u517c\u9996\u5e2d\u79d1\u5b66\u5b98\u8868\u793a\uff0c\u80be\u635f\u4f24\u662f2\u578b\u7cd6\u5c3f\u75c5\u6700\u5e38\u89c1\u7684\u5e76\u53d1\u75c7\u4e4b\u4e00\uff0c\u800c\u76ee\u524d\u9002\u7528\u4e8e\u8fd9\u4e00\u60a3\u8005\u4eba\u7fa4\u7684\u53e3\u670d\u836f\u7269\u5ed6\u5ed6\u65e0\u51e0\u3002PIONEER 5\u8bd5\u9a8c\u8bc1\u5b9e\u4e86\u53e3\u670dsemaglutide\u5bf9\u4f34\u6709\u80be\u635f\u4f24\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u63a8\u52a8\u53e3\u670dsemaglutide\u7528\u4e8e\u8fd9\u4e00\u9002\u5e94\u8bc1\u7684\u884c\u653f\u7533\u62a5\u5de5\u4f5c\uff0c\u5e76\u6700\u7ec8\u4e3a\u4f34\u6709\u80be\u635f\u4f24\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5e26\u6765\u798f\u97f3\u3002<\/span><\/p>\n

Semaglutide\u662f\u8bfa\u548c\u8bfa\u5fb7\u7ee7\u5229\u62c9\u9c81\u80bd\u4e4b\u540e\u63a8\u51fa\u7684\u8be5\u516c\u53f8\u65d7\u4e0b\u7b2c\u4e8c\u4e2aGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7c7b\u964d\u7cd6\u836f\uff0c\u5176\u76ae\u4e0b\u6ce8\u5c04\u5242\u4e8e2017\u5e7412\u6708\u83b7FDA\u6279\u51c6\u65f6\u5c31\u56e0\u4e3a\u957f\u6548\u4e0e\u663e\u8457\u7684\u8840\u7cd6\u63a7\u5236\u6548\u679c\uff0c\u4ee5\u53ca\u63a7\u5236\u8840\u7cd6\u4ee5\u5916\u7684\u4e34\u5e8a\u6548\u76ca\uff0c\u800c\u88ab\u8a89\u4e3a\u201c\u6700\u597d\u7684\u964d\u7cd6\u836f\u201d\u3002\u6b64\u540e\uff0c\u8bfa\u548c\u8bfa\u5fb7\u9664\u4e86\u7ee7\u7eed\u63a8\u52a8SUSTAIN\u7cfb\u5217\u4e34\u5e8a\u9879\u76ee\uff0c\u8fd8\u79ef\u6781\u627f\u529e\u3001\u53c2\u4e0e\u6216\u8d44\u52a9\u5404\u79cd\u4e0e\u4e4b\u76f8\u5173\u7684\u4e34\u5e8a\u8bd5\u9a8c\u30022018\u5e746\u6708\u4ee5\u6765\uff0c\u5c31\u6709\u4e8c\u5341\u591a\u9879\u7814\u7a76\u89c1\u8bf8\u62a5\u9053\uff0c\u4ece\u5404\u65b9\u9762\u5bf9semaglutide\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u4e88\u4ee5\u4e86\u5145\u5206\u7684\u8bba\u8bc1\u3002<\/span><\/p>\n

\u9664\u4e86\u6ce8\u5c04\u5242\u578b\u964d\u7cd6\u3001\u964d\u4f53\u91cd\u6548\u679c\u4ee4\u4eba\u77a9\u76ee\uff0c\u6b63\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684\u53e3\u670d\u5242\u578b\u4e5f\u662fsemaglutide\u7684\u53c8\u4e00\u5927\u4eae\u70b9\uff0c\u82e5\u80fd\u6210\u529f\u83b7\u6279\u4e0a\u5e02\uff0c\u5219\u6709\u671b\u4f7fsemaglutide\u6210\u4e3a\u7b2c\u4e00\u4e2a\u53e3\u670d\u7ed9\u836f\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u5728\u7ed9\u539f\u7814\u516c\u53f8\u5e26\u6765\u5de8\u5927\u5546\u4e1a\u56de\u62a5\u7684\u540c\u65f6\uff0c\u4e5f\u4f1a\u6210\u4e3a\u5e7f\u59272\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u4e00\u5927\u798f\u97f3\u3002<\/span><\/p>\n

<\/span><\/p>\n

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Semaglutide\u7684\u6700\u65b0\u7814\u7a76\u52a8\u6001<\/strong><\/p>\n<\/section>\n

Sharma R et al. Comparative efficacy of once-weekly semaglutide and SGLT-2 inhibitors in type 2 diabetic patients inadequately controlled with metformin monotherapy: a systematic literature review and network meta-analysis. Curr Med Res Opin. 2018 Sep;34(9):1595-1603<\/span><\/p>\n

\u3010\u7814\u7a76\u7c7b\u578b\u3011\u7efc\u8ff0\u7814\u7a76\u4e0e\u835f\u8403\u5206\u6790\uff0c\u8bfa\u548c\u8bfa\u5fb7\u53c2\u4e0e\u6216\u8d44\u52a9\uff0c\u6bd4\u8f83\u4e86\u6bcf\u5468\u6ce8\u5c04\uff08qw\uff09\u4e00\u6b21\u7684semaglutide\u4e0e\u94a0-\u8461\u8404\u7cd6\u540c\u5411\u8f6c\u8fd0\u4f53-2\u6291\u5236\u5242\uff08SGLT-2is\uff09\u5bf92\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840\u7cd6\u53ca\u5176\u4ed6\u76f8\u5173\u98ce\u9669\u56e0\u5b50\u7684\u6539\u5584\u6548\u679c<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u8be5\u9879\u835f\u8403\u5206\u6790\u5171\u7eb3\u5165\u4e868\u9879\u65f6\u957f\u226520\u5468\u7684\u968f\u673a\u5316\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7ed3\u679c\u53d1\u73b0\uff0c1.0mg qw\u4e0e0.5mg qw\u4e24\u4e2a\u5242\u91cf\u7684Semaglutide\u5bf9HbA1c\u7684\u6539\u5584\u6548\u679c\u5747\u663e\u8457\u4f18\u4e8e\u53e3\u670dSGLT-2is\uff0c\u5176\u4e2d\uff0cSemaglutide 1.0mg qd \u7684HbA1c\u8f83\u57fa\u7ebf\u53d8\u5316\u503c\u4e0e\u5361\u683c\u5217\u51c0\u53ca\u8fbe\u683c\u5217\u51c0\u76f8\u6bd4\u7684\u5e73\u5747\u5dee\u503c\u5206\u522b\u4e3a-0.66% (95% CI: -0.82, -0.50%)\u4e0e-1.11% (95% CI: -1.37, -0.85%)\u3002\u6b64\u5916\uff0csemaglutide 1.0mg qw\u7684\u51cf\u91cd\u6548\u679c\u4e0e\u6539\u5584\u7a7a\u8179\u8840\u7cd6\u7684\u6548\u679c\u4e5f\u663e\u8457\u4f18\u4e8e\u6240\u6709\u7684SGLT-2is\uff0c\u4f46\u964d\u4f4e\u6536\u7f29\u538b\u7684\u6548\u679c\u6ca1\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5dee\u5f02\u3002<\/span><\/p>\n

\u3010\u7ed3\u8bba\u3011\u6bcf\u5468\u4e00\u6b21\u7684Semaglutide\u5bf9\u5148\u524d\u5355\u72ec\u4f7f\u7528\u4e8c\u7532\u53cc\u80cd\u4f46\u75c5\u60c5\u672a\u83b7\u6709\u6548\u63a7\u5236\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840\u7cd6\u63a7\u5236\u6548\u679c\u663e\u8457\u4f18\u4e8eSGLT-2is\u3002<\/span><\/p>\n

Carlsson Petri KC et al. Semaglutide s.c. Once-Weekly in Type 2 Diabetes: A Population Pharmacokinetic Analysis. Diabetes Ther. 2018 Aug;9(4):1533-1547<\/span><\/p>\n

\u3010\u7814\u7a76\u7c7b\u578b\u3011\uff1a\u4eba\u7fa4\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\uff0c\u8bfa\u548c\u8bfa\u5fb7\u4e3b\u529e<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u8be5\u9879\u7814\u7a76\u5171\u7eb3\u5165\u4e86\u9009\u81eaNCT02054897\u3001NCT01930188\u3001NCT01885208\u3001NCT01720446 \u4e0eNCT02207374\u7b49\u4e34\u5e8a\u8bd5\u9a8c\u76841612\u540d\u53d7\u8bd5\u8005\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u3002\u6240\u8ff0\u4e34\u5e8a\u8bd5\u9a8c\u5747\u5c5e\u4e8e\u6bcf\u5468\u6ce8\u5c04\u7ed9\u836f\u4e00\u6b21\u7684semaglutide\u7684SUSTAIN\u7814\u53d1\u9879\u76ee\uff0c\u5176\u65f6\u957f\u572830~104\u5468\u4e4b\u95f4\u4e0d\u7b49\u3002<\/span><\/p>\n

\u8be5\u9879\u4eba\u7fa4\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u6027\u522b\u3001\u5e74\u9f84\u3001\u4eba\u79cd\u3001\u6c11\u65cf\u3001\u80be\u529f\u80fd\u72b6\u6001\u3001\u4f53\u91cd\u4e0e\u6ce8\u5c04\u90e8\u4f4d\u3001\u7b49\u53d8\u91cf\u4e2d\uff0c\u53ea\u6709\u4f53\u91cd\u4f1a\u663e\u8457\u5f71\u54cdsemaglutide\u7684\u4f53\u5185\u66b4\u9732\u6c34\u5e73\uff0c\u800c\u4e14semaglutide\u7684\u66b4\u9732\u6c34\u5e73\u4e0d\u968f\u65f6\u95f4\u7684\u5ef6\u957f\u800c\u53d8\u5316\u3002\u5c11\u6570\u53d7\u8bd5\u8005\u4f53\u5185\u4f1a\u51fa\u73b0semaglutide\u6297\u4f53\uff0c\u4f46\u8be5\u6297\u4f53\u4e0d\u5f71\u54cd\u836f\u7269\u7684\u4f53\u5185\u66b4\u9732\u6c34\u5e73\u3002\u6b64\u5916\uff0c\u8be5\u9879\u7814\u7a76\u8fd8\u53d1\u73b0\uff0c0.5mg\u4e0e1.0mg Semaglutide\u5b58\u5728\u6709\u6bd4\u4f8b\u5316\u5242\u91cf\u53cd\u5e94\u5173\u7cfb\u3002<\/span><\/p>\n

\u3010\u7ed3\u8bba\u3011\u4e0d\u540c\u7684\u4eba\u7fa4\u4f7f\u7528semaglutide\u63a7\u5236\u8840\u7cd6\u65f6\u65e0\u9700\u5bf9\u5176\u7528\u836f\u5242\u91cf\u8fdb\u884c\u8c03\u6574\uff0c\u4f46\u8fd9\u4e00\u7ed3\u8bba\u4ecd\u7136\u9700\u8981\u66b4\u9732-\u54cd\u5e94\u5206\u6790\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u8003\u8bc1\u3002<\/span><\/p>\n

Demmel V et al. No QTc Prolongation with Semaglutide: A Thorough QT Study in Healthy Subjects. Diabetes Ther. 2018 Aug;9(4):1441-1456<\/span><\/p>\n

\u3010\u7814\u7a76\u7c7b\u578b\u3011\u836f\u6548\u5b66\u7814\u7a76\uff0cNCT02064348\uff0c\u8bfa\u548c\u8bfa\u5fb7\u53c2\u4e0e\u6216\u8d44\u52a9\uff0c\u8bc4\u4ef7semaglutide\u5bf9\u5065\u5eb7\u53d7\u4f53\u8005QTc\u533a\u6bb5\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011168\u540d\u5065\u5eb7\u53d7\u8bd5\u8005\u968f\u673a\u5206\u7ec4\u540e\u5206\u522b\u91c7\u7528semaglutide\uff08N=83\uff09\u4e0e\u5b89\u6170\u5242\u76ae\u4e0b\u6ce8\u5c04\uff08N=83\uff09\uff0c\u5176\u4e2dsemaglutide\u7684\u6700\u9ad8\u5242\u91cf\u4e3a1.5mg\uff0c\u9ad8\u4e8e\u6cbb\u7597\u5242\u91cf\u3002\u6839\u636e\u6700\u540e\u4e00\u52421.5mg\u7ed9\u836f\u540e0~48\u5c0f\u65f6\u5185\u8bb0\u5f55\u768411\u5f20\u5fc3\u7535\u56fe\uff0c\u6240\u6709\u5242\u91cf\uff080.5mg\u30011.0mg\u4e0e1.5mg\uff09\u7684semaglutide\u90fd\u4e0d\u4f1a\u5ef6\u957f\u53d7\u8bd5\u8005\u7684QTc\u533a\u6bb5\u3002\u5404\u5242\u91cf\u4e0e\u5404\u65f6\u95f4\u70b9semaglutide\u7ec4\u51cf\u53bb\u5b89\u6170\u5242\u6548\u5e94\u540eQTc\u533a\u6bb5\u7684\u53d8\u5316\u503c\u5747\uff1c10ms\u3002\u8fdb\u4e00\u6b65\u7684\u66b4\u9732-\u54cd\u5e94\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0cQTc\u533a\u6bb5\u7684\u957f\u77ed\u4e0d\u53d7semaglutide\u6d53\u5ea6\u7684\u5f71\u54cd\u3002Semaglutide\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u76f8\u4f3c\u3002<\/span><\/p>\n

\u3010\u7ed3\u8bba\u3011\u7531\u4e8e\u8be5\u9879\u8bd5\u9a8c\u4e2dsemaglutide\u4e0d\u5ef6\u957f\u5065\u5eb7\u5fd7\u613f\u8005\u5fc3\u810f\u590d\u6781\u6240\u9700\u8981\u7684\u65f6\u95f4\uff0c\u56e0\u6b64\u65e0\u987b\u5173\u6ce8\u5176\u662f\u5426\u4f1a\u5f15\u53d1\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u3002<\/span><\/p>\n

B\u00e6kdal TA et al. A randomized study investigating the effect of omeprazole on the pharmacokinetics of oral semaglutide. Expert Opin Drug Metab Toxicol. 2018 Aug;14(8):869-877.<\/span><\/p>\n

\u3010\u7814\u7a76\u7c7b\u578b\u3011\u836f\u7269-\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7814\u7a76\uff0c\u5355\u4e2d\u5fc3\u3001\u968f\u673a\u5316\u3001\u5f00\u653e\u6807\u7b7e\u3001\u5e73\u884c\u7ec4\u7814\u7a76\uff0c\u8bfa\u548c\u8bfa\u5fb7\u4e3b\u529e\uff0c\u8bc4\u4ef7\u53e3\u670dsemaglutide\u4e0e\u5965\u7f8e\u62c9\u5511\uff0840mg qd\uff09\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u76f8\u4e92\u4f5c\u7528<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u8be5\u9879\u7814\u7a76\u5171\u7eb3\u516554\u540d\u5065\u5eb7\u5fd7\u613f\u8005\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u4e0esemaglutide\u5355\u72ec\u7ed9\u836f\u76f8\u6bd4\uff0csemaglutide\u4e0e\u5965\u7f8e\u62c9\u5511\u8054\u5408\u7528\u836f\u540e\u7684semaglutide\u4f53\u5185\u66b4\u9732\u6c34\u5e73\u6709\u5c0f\u5e45\u4e0a\u5347\uff0c\u4f46\u65e0\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002\u800c\u4e14\u8054\u5408\u7528\u836f\u540e\u53d7\u8bd5\u8005\u7684\u80c3\u5185pH\u503c\u4e5f\u9ad8\u4e8esemaglutide\u5355\u72ec\u7ed9\u836f\u7684\u60c5\u51b5\u3002\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u4e0d\u826f\u53cd\u5e94\u5747\u5448\u8f7b\u81f3\u4e2d\u5ea6\uff0c\u4e14\u5927\u591a\u662f\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/p>\n

\u3010\u7ed3\u8bba\u3011Semaglutide\u4e0e\u5965\u7f8e\u62c9\u5511\u540c\u65f6\u53e3\u670d\u7ed9\u836f\uff0c\u4f1a\u5347\u9ad8\u524d\u8005\u7684\u4f53\u5185\u66b4\u9732\u6c34\u5e73\uff0c\u4f46\u8fd9\u79cd\u5347\u9ad8\u65e0\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff0c\u800c\u4e14\u4e5f\u65e0\u4e34\u5e8a\u76f8\u5173\u6027\uff0c\u56e0\u6b64\uff0c\u4e24\u8005\u540c\u65f6\u8054\u5408\u53e3\u670d\u7ed9\u836f\u65f6\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<\/span><\/p>\n

Overgaard RV. Switching from other GLP-1 receptor agonists to semaglutide – impact on HbA1c and body weight: A model-based approach. Diabetes Obes Metab. 2018 Jul 25.[Epub ahead of print]<\/span><\/p>\n

\u3010\u7814\u7a76\u7c7b\u578b\u3011\u57fa\u4e8e\u6a21\u578b\u7684\u7814\u7a76\uff0c\u8bfa\u548c\u8bfa\u5fb7\u4e3b\u529e\uff0c\u8bc4\u4ef7\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d7\u8bd5\u8005\u4ece\u5176GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u6362\u7528semaglutide\u540e\u5bf9\u5176HbA1c\u4e0e\u4f53\u91cd\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u8be5\u9879\u7814\u7a76\u91c7\u7528semaglutide 3\u671f\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u4e2d4\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6700\u957f30\u5468\u7684\u89c2\u5bdf\u6570\u636e\uff0c\u5206\u522b\u5efa\u7acb\u4e86HbA1c\u4e0e\u4f53\u91cd\u7684\u65f6\u95f4\u8fdb\u7a0b\u6a21\u578b\u3002\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u4ece\u53e6\u4e00\u79cdGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u6362\u7528semaglutide\uff0c\u4f1a\u5347\u9ad8\u7ecf\u6548\u529b\u8c03\u6574\u540e\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u6574\u4f53\u6709\u6548\u6d53\u5ea6\uff0csemaglutide 10mg\u4f1a\u4f7fHbA1c\u964d\u4f4e0.3%~0.8%\u4e2a\u70b9\uff0c\u4f7f\u4f53\u91cd\u964d\u4f4e2%~4%\u3002\u82e5\u4ece\u5229\u62c9\u9c81\u80bd1.2\/1.8mg\u6216\u5ea6\u62c9\u9c81\u80bd\u6362\u7528semaglutide 0.25mg\uff0c\u5219\u4f1a\u4f7fHbA1c\u51fa\u73b0\u77ed\u6682\u7684\u6076\u5316\u7684\u73b0\u8c61\u3002<\/span><\/p>\n

\u3010\u7ed3\u8bba\u3011\u5148\u524d\u4f7f\u7528\u5229\u62c9\u9c81\u80bd\u3001\u5ea6\u62c9\u9c81\u80bd\u6216\u827e\u585e\u90a3\u80bd\u7f13\u91ca\u5236\u5242\u63a7\u5236\u8840\u7cd6\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5728\u6362\u7528semaglutide\u4e4b\u540e\uff0c\u4f1a\u4f7f\u5176HbA1c\u4e0e\u4f53\u91cd\u8fdb\u4e00\u6b65\u964d\u4f4e\u3002\u867d\u7136\u6362\u7528semaglutide 0.25mg\u7684\u7ed3\u5c40\u6570\u503c\u4f1a\u6709\u5c0f\u5e45\u6076\u5316\uff0c\u4f46\u5374\u53ef\u4ee5\u901a\u8fc7\u4e00\u5f00\u59cb\u5c31\u91c7\u7528\u9ad8\u5242\u91cfsemaglutide\u7684\u7b56\u7565\u4e88\u4ee5\u907f\u514d\u3002<\/span><\/p>\n

Lingvay I et al. A 26-Week Randomized Controlled Trial of Semaglutide Once Daily Versus Liraglutide and Placebo in Patients With Type 2 Diabetes Suboptimally Controlled on Diet and Exercise With or Without Metformin. Diabetes Care. 2018 Jul 19. [Epub ahead of print]<\/span><\/p>\n

\u3010\u7814\u7a76\u7c7b\u578b\u3011\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u968f\u673a\u5316\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bfa\u548c\u8bfa\u5fb7\u53c2\u4e0e\u6216\u8d44\u52a9\uff0c\u6bd4\u8f83\u6bcf\u5929\u4e00\u6b21\u7684semaglutide\u4e0e\u5229\u62c9\u9c81\u80bd\u5bf92\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005HbA1c\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u8be5\u9879\u4e3a\u671f26\u5468\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5c06705\u540d2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u63092:2:1\u7684\u6bd4\u4f8b\uff0c\u968f\u673a\u5206\u5165semaglutide qd\u3001\u5229\u62c9\u9c81\u80bd qd\u4e0e\u5b89\u6170\u5242\u7ec4\uff0c\u5404\u7ec4\u91c7\u7528\u5bb9\u91cf\u5339\u914d\u7684\u5242\u91cf\u8fdb\u884c\u7ed9\u836f\u3002\u7b2c26\u5468\u65f6\uff0csemaglutide qd\u7ec4\u53d7\u8bd5\u8005HbA1c\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\u503c\u5728-1.1% (0.05 mg) \u81f3 -1.9% (0.3 mg)\u4e4b\u95f4\uff0c\u5229\u62c9\u9c81\u80bd qd\u7ec4\u53d7\u8bd5\u8005HbA1c\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\u503c\u5728-0.5% (0.3 mg)\u81f3-1.3% (1.8 mg)\u4e4b\u95f4\uff0c\u5747\u5177\u6709\u5242\u91cf\u4f9d\u8d56\u6027\uff0c\u800c\u4e14\u5404\u5bb9\u91cf\u5339\u914d\u7684\u5242\u91cf\u4e0b\uff0csemaglutide\u7684\u6548\u679c\u5747\u663e\u8457\u4f18\u4e8e\u5229\u62c9\u9c81\u80bd\u3002Semaglutide\u7ec4\u4e0e\u5229\u62c9\u9c81\u80bd\u7ec4\u5185\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\uff0c\u53d1\u75c5\u7387\u5206\u522b\u4e3a32.8~54.0%\u4e0e21.9~41.5%\u3002<\/span><\/p>\n

\u3010\u7ed3\u8bba\u3011\u6700\u9ad8\u5242\u91cf\u76840.3mg\/d\u7684\u6bcf\u5929\u4e00\u6b21\u7684semaglutide\u964d\u4f4eHbA1c\u7684\u6548\u679c\u663e\u8457\u4f18\u4e8e\u5229\u62c9\u9c81\u80bd\u6216\u5b89\u6170\u5242\uff0c\u4f46\u5176\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6\u7684\u53d1\u751f\u7387\u9ad8\u4e8e\u540e\u4e24\u8005\u3002<\/span><\/p>\n

Korsatko S et al. Effect of once-weekly semaglutide on the counterregulatory response to hypoglycaemia in people with type 2 diabetes: A randomized, placebo-controlled, double-blind, crossover trial. Diabetes Obes Metab. 2018 Jun 12. [Epub ahead of print]<\/span><\/p>\n

\u3010\u7814\u7a76\u7c7b\u578b\u3011\u5355\u4e2d\u5fc3\u3001\u968f\u673a\u5316\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bfa\u548c\u8bfa\u5fb7\u53c2\u4e0e\u6216\u8d44\u52a9\uff0c\u8bc4\u4ef7\u6bcf\u5468\u4e00\u6b21\u7684semaglutide\u5bf92\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4f4e\u8840\u7cd6\u53cd\u8c03\u63a7\u53cd\u5e94\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c38\u540d\u6b63\u5728\u53ea\u91c7\u7528\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u968f\u673a\u5206\u5165semaglutide qw\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\uff0c12\u5468\u540e\u4ea4\u6362\u7528\u836f\uff0c\u5e76\u5728\u6bcf\u4e2a\u4ea4\u53c9\u671f\u540e\u8fdb\u884c\u4f4e\u8840\u7cd6\u94b3\u5939\u64cd\u4f5c\u3002<\/span><\/p>\n

\u57285.5 mmol\/L PG\u5230\u6700\u4f4e\u70b9\u7684\u4f4e\u8840\u7cd6\u94b3\u5939\u8fc7\u7a0b\u4e2d\uff0csemaglutide\u4e0e\u5b89\u6170\u5242\u7ec4\u7684\u80f0\u9ad8\u8840\u7cd6\u7d20\u6c34\u5e73\u53d8\u5316\u60c5\u51b5\u76f8\u4f3c\uff0c\u5206\u522b\u4e3a88.3pg\/mL\u4e0e83.1pg\/mL\uff08\u4f30\u7b97\u5dee\u503c\u4e3a5.2pg\/mL\uff0c95%CI\u4e3a-7.7~18.1\uff09\u3002Semaglutide\u4e0e\u5b89\u6170\u5242\u5747\u53ef\u5347\u9ad8\u5176\u4ed6\u7684\u53cd\u8c03\u63a7\u6fc0\u7d20\uff0c\u5176\u4e2dsemaglutide\u5347\u9ad8\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u4e0e\u76ae\u8d28\u9187\u7684\u7a0b\u5ea6\u663e\u8457\u4f4e\u4e8e\u5b89\u6170\u5242\u3002\u4e24\u4e2a\u6cbb\u7597\u7ec4\u7ef4\u6301\u6052\u5b9a\u94b3\u5939\u6c34\u5e73\u6240\u9700\u8981\u7684\u8461\u8404\u7cd6\u704c\u6ce8\u901f\u7387\u5f7c\u6b64\u76f8\u4f3c\uff0c\u8bf4\u660e\u4e24\u7ec4\u53cd\u8c03\u63a7\u53cd\u5e94\u6c34\u5e73\u6574\u4f53\u4e0a\u76f8\u4f3c\u3002\u6700\u4f4e\u503c\u65f6semaglutide\u7ec4\u5e73\u5747\u4f4e\u8840\u7cd6\u75c7\u72b6\u8bc4\u5206\u4e0e\u4f4e\u8840\u7cd6\u60a3\u8005\u6240\u5360\u6bd4\u4f8b\u5747\u5747\u4f4e\u4e8e\u5b89\u6170\u5242\u7ec4\uff0c\u4f46\u4e24\u7ec4\u8ba4\u8bc6\u529f\u80fd\u6d4b\u8bd5\u7ed3\u679c\u5f7c\u6b64\u76f8\u4f3c\u3002Semaglutide\u7ec4\u672a\u89c1\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002<\/span><\/p>\n

\u3010\u7ed3\u8bba\u3011Semaglutide\u4e0d\u7834\u574f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u53d1\u751f\u4f4e\u8840\u7cd6\u65f6\u7684\u53cd\u8c03\u63a7\u6027\u7684\u80f0\u9ad8\u8840\u7cd6\u7d20\u53cd\u5e94\u3002<\/span><\/p>\n

Webb N et al. A Network Meta-Analysis Comparing Semaglutide Once-Weekly with Other GLP-1 Receptor Agonists in Japanese Patients with Type 2 Diabetes. Diabetes Ther. 2018 Jun;9(3):973-986<\/span><\/p>\n

\u3010\u7814\u7a76\u7c7b\u578b\u3011\u835f\u8403\u5206\u6790\uff0c\u8bfa\u548c\u8bfa\u5fb7\u53c2\u4e0e\u6216\u8d44\u52a9\uff0c\u6bd4\u8f83\u6bcf\u5468\u4e00\u6b21\u7684semaglutide\u4e0e\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u5bf9\u65e5\u672c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u8be5\u9879\u835f\u8403\u5206\u6790\u5171\u7eb3\u5165\u4e864\u9879\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7ed3\u679c\u663e\u793a\uff0csemaglutide 0.5mgqw\u964dHbA1c\u7684\u6548\u679c[-\u20090.61% (12.3 mmol\/mol)]\u3001\u51cf\u8f7b\u4f53\u91cd\u7684\u6548\u679c(-\u20091.45 kg)\u3001\u964d\u4f4e\u6536\u7f29\u538b\u7684\u6548\u679c (-\u20095.03 mmHg)\u4ee5\u53ca\u964d\u4f4e\u7a7a\u8179\u8840\u7cd6\u7684\u6548\u679c(-\u20091.26 mmol\/L)\u5747\u663e\u8457\u4f18\u4e8e\u5ea6\u62c9\u9c81\u80bd0.75mg qw\uff0c\u800csemaglutide 0.5mg qw\u4e0e\u5ea6\u62c9\u9c81\u80bd0.75mg qw\u6cbb\u7597\u540e\u5b9e\u73b0HbA1c \u6c34\u5e73\u2009<\u20097% (53 mmol\/mol)\u7684\u8840\u7cd6\u63a7\u5236\u6548\u679c\u7684\u60a3\u8005\u6240\u5360\u6bd4\u4f8b\u4e0e\u6574\u4f53\u4f4e\u8840\u7cd6\u98ce\u9669\u5747\u65e0\u663e\u8457\u5dee\u5f02\u3002<\/span><\/p>\n

\u3010\u7ed3\u8bba\u3011semaglutide 0.5mg QW\u5bf9\u65e5\u672c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005HbA1c\u3001\u4f53\u91cd\u3001\u6536\u7f29\u538b\u4e0e\u7a7a\u8179\u8840\u7cd6\u7684\u6539\u5584\u6548\u679c\u5747\u663e\u8457\u4f18\u4e8e\u5ea6\u62c9\u9c81\u80bd0.75mg qd\u3002<\/span><\/p>\n

Wilkinson L et al. Cost of Achieving HbA1c Treatment Targets and Weight Loss Responses with Once-Weekly Semaglutide Versus Dulaglutide in the United States. Diabetes Ther. 2018 Jun;9(3):951-961.<\/span><\/p>\n

\u3010\u7814\u7a76\u7c7b\u578b\u3011\u6210\u672c-\u6548\u76ca\u6bd4\u8f83\u7814\u7a76\uff0c\u8bfa\u548c\u8bfa\u5fb7\u4e3b\u529e\uff0c\u6bd4\u8f83\u7f8e\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2dsemaglutide qw\u4e0e\u5ea6\u62c9\u9c81\u80bdqw\u6cbb\u7597\u5b9e\u73b0HbA1c\u4e0e\u4f53\u91cd\u63a7\u5236\u76ee\u6807\u6240\u9700\u8981\u7684\u6210\u672c\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u91c7\u7528\u6bcf\u5468\u4e00\u6b21semaglutide\u6cbb\u7597\u540e\u5b9e\u73b0HbA1c\u63a7\u5236\u76ee\u6807\u7684\u60a3\u8005\u591a\u4e8e\u91c7\u7528\u6bcf\u5468\u4e00\u6b21\u5ea6\u62c9\u9c81\u80bd\u7684\u6548\u679c\u3002\u6bcf\u540d\u60a3\u8005\u5b9e\u73b0\u4e09\u91cd\u6cbb\u7597\u7ec8\u70b9\u6240\u9700\u8981\u7684\u6210\u672c\u5206\u522b\u4e3a11961\u7f8e\u5143\uff08semaglutide 1.0mg qw\uff09\u4e0e15204\u7f8e\u5143\uff08\u5ea6\u62c9\u9c81\u80bd 1.5mg qw\uff09\uff0c\u540e\u8005\u9ad8\u51fa\u524d\u800528%\u3002\u91c7\u7528\u5ea6\u62c9\u9c81\u80bd0.75mg qw\u6cbb\u7597\u5b9e\u73b0\u4e0a\u8ff0\u76ee\u6807\u7684\u6210\u672c\u6bd4semaglutide 0.5mg qw\u9ad8\u51fa68%\u3002\u5bf9\u4e8e\u6bcf\u540d\u5b9e\u73b0HbA1c\u2009<\u20097%\u7684\u8840\u7cd6\u63a7\u5236\u76ee\u6807\u7684\u60a3\u8005\u800c\u8a00\uff0c\u5ea6\u62c9\u9c81\u80bd1.5mg qw\u7684\u6210\u672c\u6bd4semaglutide 1.0mg qw\u9ad818%\u3002<\/span><\/p>\n

\u3010\u7ed3\u8bba\u3011\u5bf9\u4e8e\u7f8e\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u800c\u8a00\uff0c\u6bcf\u5468\u4e00\u6b21\u7684semaglutide\u7684\u6210\u672c\u6548\u76ca\u7279\u5f81\u4f18\u4e8e\u6bcf\u5468\u4e00\u6b21\u7684\u5ea6\u62c9\u9c81\u80bd\u3002<\/span><\/p>\n

Rodbard HW et al. Semaglutide Added to Basal Insulin in Type 2 Diabetes (SUSTAIN 5): A Randomized, Controlled Trial. J Clin Endocrinol Metab. 2018 Jun 1;103(6):2291-2301<\/span><\/p>\n

\u3010\u7814\u7a76\u7c7b\u578b\u3011\u968f\u673a\u5316\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bfa\u548c\u8bfa\u5fb7\u53c2\u4e0e\uff0c\u8bc4\u4ef7\u5728\u57fa\u7840\u80f0\u5c9b\u7d20\u7684\u57fa\u7840\u4e0a\u6dfb\u52a0semaglutide\u540e\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u8be5\u9879\u7814\u7a76\u5c5e\u4e8esemaglutide\u7684SUSTAIN\u7cfb\u5217\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\uff0c\u5176\u7eb3\u5165\u4e86397\u540d\u5148\u524d\u91c7\u7528\u7a33\u5b9a\u5242\u91cf\u7684\u57fa\u7840\u80f0\u5c9b\u7d20\uff08\u00b1\u4e8c\u7532\u53cc\u80cd\uff09\u4f46\u8840\u7cd6\u672a\u83b7\u6709\u6548\u63a7\u5236\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3002\u5206\u522b\u91c7\u7528semaglutide 0.5mg qw\u30011.0mg qw\u6216\u5b89\u6170\u5242\u6cbb\u759730\u5468\u540e\uff0c\u5404\u7ec4\u7684HbA1c\u503c\uff08\u5e73\u5747\u57fa\u7ebf\u6c34\u5e73\u4e3a8.4%\uff09\u4f9d\u6b21\u5e73\u5747\u964d\u4f4e\u4e861.4%\u30011.8%\u4e0e0.1%\uff0c\u4e24\u4e2a\u5242\u91cf\u7684semaglutide\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u7684P\u503c<0.0001\u3002semaglutide 0.5mg qw\u7ec4\u30011.0mg qw\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u4f9d\u6b21\u670911\u540d\u300114\u540d\u4e0e7\u540d\u53d7\u8bd5\u8005\u51fa\u73b0\u4e25\u91cd\u7684\u6216\u7ecf\u8840\u7cd6\u8bc1\u5b9e\u7684\u4f4e\u8840\u7cd6\uff0csemaglutide\u4e24\u4e2a\u5242\u91cf\u7ec4\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5747\u65e0\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5dee\u5f02\u3002\u4e09\u7ec4\u53d7\u8bd5\u8005\u4f53\u91cd\u4f9d\u6b21\u8f83\u57fa\u7ebf\u51cf\u8f7b\u4e863.7kg\uff08semaglutide 0.5mg qw\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4P<0.0001\uff09\u30016.4kg\uff08semaglutide 1.0mg qw\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4P<0.0001\uff09\u4e0e1.4kg\uff08\u5b89\u6170\u5242\uff09\u3002Semaglutide 0.5mg qw\u7ec4\u4e0e1.0mg qw\u7ec4\u5206\u522b\u67094.5%\u4e0e6.1%\u7684\u53d7\u8bd5\u8005\u56e0\u4e0d\u826f\u53cd\u5e94\u800c\u63d0\u524d\u505c\u6b62\u6cbb\u7597\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u7684\u8fd9\u4e00\u6570\u503c\u4ec5\u4e3a0.8%\u3002\u5bfc\u81f4\u53d7\u8bd5\u8005\u63d0\u524d\u505c\u6b62\u6cbb\u7597\u7684\u4e0d\u826f\u53cd\u5e94\u4e3b\u8981\u662f\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/p>\n

\u3010\u7ed3\u8bba\u3011\u5728\u57fa\u7840\u80f0\u5c9b\u7d20\u7684\u57fa\u7840\u4e0a\u6dfb\u52a0semaglutide\u6cbb\u7597\u53ef\u663e\u8457\u6539\u5584\u8840\u7cd6\u63a7\u5236\u6548\u679c\u6b20\u4f73\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684HbA1c\u4e0e\u4f53\u91cd\u7684\u63a7\u5236\u6548\u679c\u3002<\/span><\/p>\n

\"\u8bfa\u548c\u8bfa\u5fb7\u53e3\u670dSemaglutide\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u53c8\u4e00\u7a81\u7834\uff01\"<\/p>\n

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