{"id":40954,"date":"2018-08-14T01:00:00","date_gmt":"2018-09-17T06:48:37","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e5%b8%83%e9%b2%81%e9%a1%bf%e6%b0%8f%e9%85%aa%e6%b0%a8%e9%85%b8%e6%bf%80%e9%85%b6%e6%8a%91%e5%88%b6%e5%89%82pct%e5%8c%96%e5%90%88%e7%89%a9%e4%b8%93%e5%88%a9%e5%88%86%e6%9e%90\/"},"modified":"2018-09-17T14:48:42","modified_gmt":"2018-09-17T06:48:42","slug":"%e5%b8%83%e9%b2%81%e9%a1%bf%e6%b0%8f%e9%85%aa%e6%b0%a8%e9%85%b8%e6%bf%80%e9%85%b6%e6%8a%91%e5%88%b6%e5%89%82pct%e5%8c%96%e5%90%88%e7%89%a9%e4%b8%93%e5%88%a9%e5%88%86%e6%9e%90","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/40954\/","title":{"rendered":"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790"},"content":{"rendered":"
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\u6839\u636e\u5f3a\u751f\u5236\u836f\u8fd1\u671f\u516c\u5e03\u76842018\u5e74\u7b2c2\u5b63\u5ea6\u8d22\u52a1\u62a5\u544a\uff0c\u8be5\u516c\u53f8\u65d7\u4e0b\u7684\u4f9d\u9c81\u66ff\u5c3c\uff08\u5546\u54c1\u540dImbruvica\uff09\u57282018\u5e74\u7b2c2\u5b63\u5ea6\u5b9e\u73b0\u4e866.20\u4ebf\u7f8e\u5143\u7684\u5168\u7403\u9500\u552e\u989d\uff0c\u540c\u6bd4\u589e\u957f37.8%\uff0c\u800c\u8be5\u836f2018\u5e74\u4e0a\u534a\u5e74\u7684\u5168\u7403\u9500\u552e\u989d\u5df2\u8fbe12.07\u4ebf\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957f40.5%\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 \u5168\u65872442\u5b57\uff0c\u7528\u65f64\u5206\u949f<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4f5c\u8005\uff1a\u5411\u98de<\/p>\n

\u4f9d\u9c81\u66ff\u5c3c\u662f\u7531Pharmacyclics\u516c\u53f8\u539f\u7814\uff0c\u5e76\u7531\u5f3a\u751f\u5236\u836f\u5408\u4f5c\u9500\u552e\u7684\u5168\u7403\u9996\u4e2a\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08Bruton\u2019s Tyrosine Kinase\uff0c\u4e0b\u6587\u7b80\u79f0BTK\u6fc0\u9176\uff09\u6291\u5236\u5242\uff0c\u6700\u65e9\u4e8e2013\u5e7411\u6708\u83b7FDA\u6279\u51c6\uff0c\u76ee\u524d\u7684\u9002\u5e94\u8bc1\u5305\u62ec\uff1a\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u3001\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08SLL\uff09\u3001\u7279\u53d1\u6027\u5de8\u7403\u86cb\u767d\u8840\u75c7\u4e0e\u5916\u5957\u5c64\u6dcb\u5df4\u7624\u30022017\u5e7410\u6708\uff0cFDA\u6279\u51c6\u4e86\u7b2c\u4e8c\u4e2aBTK\u6fc0\u9176\u6291\u5236\u5242acalabrutinib\uff08\u5546\u54c1\u540dCalquence\uff09\uff0c\u7528\u4e8e\u6cbb\u7597MCL\u3002<\/p>\n

BTK\u6fc0\u9176\u662f\u4e00\u79cd\u80de\u6d46\u86cb\u767d\uff0c\u5c5e\u4e8e\u975e\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176Tec\u5bb6\u65cf\uff0c\u4e3b\u8981\u5728B\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u5206\u5e03\u4e8e\u6dcb\u5df4\u7cfb\u7edf\u9020\u8840\u53ca\u8840\u6db2\u7cfb\u7edf\uff0c\u53c2\u4e0e\u8c03\u63a7B\u7ec6\u80de\u7684\u589e\u6b96\u3001\u5206\u5316\u4e0e\u51cb\u4ea1\uff0c\u5e76\u5728\u591a\u4e2a\u4fe1\u53f7\u901a\u8def\u4e2d\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\u3002<\/p>\n

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1\u3001\u4e13\u5229\u68c0\u7d22\u4e0e\u5206\u6790\u65b9\u6cd5<\/strong><\/p>\n

\uff081\uff09\u6570\u636e\u5e93\uff1aWIPO\u7684Patentscope\u6570\u636e\u5e93<\/p>\n

\uff082\uff09\u68c0\u7d22\u5f0f\uff1a<\/p>\n

\u5f0f\u2460\uff1aEN_TI:(BTK or Bruton) AND IC:c07 AND OF:WO\uff1b<\/p>\n

\u5f0f\u2461\uff1aEN_TI:(BTK or Bruton) AND IC:c07 AND OF:WO<\/p>\n

\uff083\uff09\u6570\u636e\u5904\u7406\u4e0e\u4fe1\u606f\u63d0\u53d6<\/p>\n

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2\u3001\u7ed3\u679c<\/strong><\/p>\n

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\"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790\"<\/p>\n

\u56fe1BTK\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5e74\u5ea6\u7533\u8bf7\u91cf\u53d8\u5316\u8d8b\u52bf<\/strong><\/p>\n

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2006\u5e74\u7684\u7533\u8bf7\u91cf\u51fa\u73b0\u7b2c\u4e00\u6b21\u9aa4\u589e\uff0c\u6b64\u540e\u76f4\u81f32011\u5e74\u7684\u5e74\u5ea6\u7533\u8bf7\u91cf\u4ea6\u6709\u8d77\u4f0f\uff0c\u4f46\u6574\u4f53\u4e0a\u663e\u8457\u9ad8\u4e8e1999\u5e74~2005\u5e74\u7684\u6c34\u5e73\u3002\u8fd9\u4e00\u65f6\u671f\u5305\u62ec\u4e86\u4f9d\u9c81\u66ff\u5c3c\u7684\u5316\u5408\u7269\u4e13\u5229WO2008039218\u3002<\/p>\n

2012\u5e74\u7684\u7533\u8bf7\u91cf\u51fa\u73b0\u7b2c\u4e8c\u6b21\u9aa4\u589e\uff0c\u5176\u589e\u957f\u52bf\u6001\u4e00\u76f4\u4fdd\u6301\u81f32014\u5e74\uff0c\u8bf4\u660e\u8fd9\u4e00\u65f6\u671f\u7684BTK\u6fc0\u9176\u6291\u5236\u5242\u5f00\u53d1\u8fdb\u5165\u4e86\u9ad8\u901f\u589e\u957f\u671f\u3002\u867d\u71362014\u5e74\u4ee5\u540e\u7684\u7533\u8bf7\u91cf\u6301\u7eed\u8d70\u4f4e\uff0c\u4f46\u6bcf\u5e74\u7684\u7533\u8bf7\u91cf\u4ecd\u7136\u4fdd\u6301\u572830\u4ef6\u4ee5\u4e0a\uff0c\u800c\u4e14\u8003\u8651\u5230PCT\u4e13\u5229\u4ece\u7533\u8bf7\u5230\u516c\u5f00\u5c1a\u9700\u89816~18\u6708\u7684\u65f6\u95f4\uff0c\u56e0\u6b642017\u5e74\u7684\u7533\u8bf7\u91cf\u53ef\u80fd\u4f1a\u9ad8\u4e8e2016\u5e74\uff0c\u6240\u4ee5BTK\u6fc0\u9176\u6291\u5236\u5242\u7684\u5f00\u53d1\u662f\u5426\u5df2\u7ecf\u8fdb\u5165\u6210\u719f\u671f\u6216\u8870\u9000\u671f\u5c1a\u65e0\u5b9a\u8bba\u3002<\/p>\n

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\u88681 \u7533\u8bf7\u4eba\u5206\u6790<\/strong>
<\/p>\n

\"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790\"<\/p>\n

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3\u3001\u5316\u5408\u7269\u7ed3\u6784\u7279\u5f81\u5206\u6790<\/strong><\/p>\n

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\u2460 C07D487\/04<\/p>\n

70\u4ef6\u4e13\u5229\u4ee5\u6b64\u4e3a\u4e3b\u5206\u7c7b\u53f7\uff0c\u8be5\u5206\u7c7b\u53f7\u4ee3\u8868\u5728\u7a20\u73af\u7cfb\u4e2d\u542b\u6709\u6c2e\u539f\u5b50\u4f5c\u4e3a\u4ec5\u6709\u7684\u6742\u73af\u539f\u5b50\u7684\u6742\u73af\u5316\u5408\u7269\uff0c\u4e0d\u5305\u542b\u5728C07D 451\/00\u81f3C07D 477\/00\u7ec4\u4e2d\uff0c\u800c\u4e14\u662f\u542b\u6709\u4e24\u4e2a\u6742\u73af\u7684\u7a20\u5408\u4f53\u7cfb\u3002<\/p>\n

\u4ee5C07D487\/04\u4e3a\u4e3b\u5206\u7c7b\u53f7\u7684BTK\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5e74\u5ea6\u7533\u8bf7\u91cf\u53d8\u5316\u8d8b\u52bf\u5982\u56fe2\u6240\u793a\u3002<\/span><\/p>\n

\"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790\"<\/p>\n

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\"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790\"<\/p>\n

\u2461 C07D401\/14<\/p>\n

24\u4ef6\u4e13\u5229\u4ee5\u6b64\u4e3a\u4e3b\u5206\u7c7b\u53f7\u3002\u8be5\u5206\u7c7b\u53f7\u5177\u4f53\u4ee3\u8868\uff1a\u542b\u67093\u4e2a\u6216\u66f4\u591a\u4e2a\u6742\u73af\u7684\u6742\u73af\u5316\u5408\u7269\uff0c\u800c\u4e14\u4ee5\u6c2e\u539f\u5b50\u4f5c\u4e3a\u4ec5\u6709\u7684\u6742\u73af\u539f\u5b50\uff0c\u81f3\u5c11\u67091\u4e2a\u73af\u662f\u4ec5\u542b\u67091\u4e2a\u6c2e\u539f\u5b50\u7684\u516d\u5143\u73af\u3002<\/p>\n

\u4ee5C07D401\/14\u4e3a\u4e3b\u5206\u7c7b\u53f7\u7684BTK\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u7684\u5e74\u5ea6\u7533\u8bf7\u8d8b\u52bf\u5982\u56fe3\u6240\u793a\u3002<\/p>\n

\"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790\"<\/p>\n

\u56fe3\u4ee5C07D401\/14\u4e3a\u4e3b\u5206\u7c7b\u53f7\u7684BTK\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5e74\u5ea6\u7533\u8bf7\u8d8b\u52bf<\/strong><\/p>\n

\u56fe3\u6240\u793a\u7684\u4e13\u5229\u4e2d\u7533\u8bf7\u65f6\u95f4\u6700\u665a\u7684\u662fWO2018033556\uff0c\u5176\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784\u5982\u4e0b\u6240\u793a\u3002<\/span><\/p>\n

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\u2462 C07D471\/04<\/p>\n

22\u4ef6\u4e13\u5229\u4ee5\u6b64\u4e3a\u4e3b\u5206\u7c7b\u53f7\uff0c\u8be5\u5206\u7c7b\u53f7\u5177\u4f53\u4ee3\u8868\uff1a<\/p>\n

C07D 471\/00\u5728\u7a20\u73af\u7cfb\u4e2d\u542b\u6709\u6c2e\u539f\u5b50\u4f5c\u4e3a\u4ec5\u6709\u7684\u6742\u73af\u539f\u5b50\u3001\u5176\u4e2d\u81f3\u5c111\u4e2a\u73af\u662f\u542b\u67091\u4e2a\u6c2e\u539f\u5b50\u7684\u516d\u5143\u73af\u7684\u6742\u73af\u5316\u5408\u7269\uff0cC07D 451\/00\u81f3C07D 463\/00\u4e0d\u5305\u62ec\u7684<\/p>\n

\u00b7\u5728\u7a20\u73af\u7cfb\u4e2d\u542b\u4e24\u4e2a\u6742\u73af<\/p>\n

\u00b7\u00b7\u90bb\u4f4d\u7a20\u73af\u7cfb<\/p>\n

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\"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790\"<\/p>\n

\u56fe4\u4ee5C07D471\/04\u4e3a\u4e3b\u5206\u7c7b\u53f7\u7684BTK\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5e74\u5ea6\u7533\u8bf7\u8d8b\u52bf<\/strong><\/p>\n

\u56fe4\u6240\u793a\u4e13\u5229\u7533\u8bf7\u65f6\u95f4\u6700\u665a\u7684\u662fWO2018035080\uff0c\u5176\u4ee3\u8868\u5316\u5408\u7269\u7ed3\u6784\u5982\u4e0b\u6240\u793a\u3002<\/p>\n

\"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790\"<\/p>\n

\u2463 C07D403\/12<\/p>\n

12\u4ef6\u4e13\u5229\u4ee5\u6b64\u4e3a\u4e3b\u5206\u7c7b\u53f7\uff0c\u8be5\u5206\u7c7b\u53f7\u5177\u4f53\u4ee3\u8868\uff1a<\/p>\n

\u6742\u73af\u5316\u5408\u7269\uff0c\u542b\u6709\u4e24\u4e2a\u6216\u66f4\u591a\u7684\u6742\u73af\uff0c\u4ee5\u6c2e\u539f\u5b50\u4f5c\u4e3a\u4ec5\u6709\u7684\u6742\u73af\u539f\u5b50\uff0cC07D 401\/00\u7ec4\u4e0d\u5305\u542b\u7684<\/p>\n

\u00b7\u542b\u4e24\u4e2a\u6742\u73af\u30142\u3015<\/p>\n

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\u56fe5\u4ee5C07D403\/12\u4e3a\u4e3b\u5206\u7c7b\u53f7\u7684BTK\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u7684\u5e74\u5ea6\u7533\u8bf7\u8d8b\u52bf<\/strong><\/p>\n

\u56fe5\u6240\u793a\u7684\u4e13\u5229\u4e2d\u7533\u8bf7\u6700\u665a\u7684\u662fWO2018098275\uff0c\u5176\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784\u5982\u4e0b\u6240\u793a\u3002<\/p>\n

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\uff082\uff09\u8fd1\u4e09\u5e74\u5185\u51fa\u73b0\u7684\u65b0\u7ed3\u6784<\/p>\n

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\u88682\u8fd15\u5e74\u5185\u51fa\u73b0\u7684\u65b0\u5206\u7c7b\u53f7\u53ca\u5176\u4ee3\u8868\u7ed3\u6784<\/strong><\/p>\n

\"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790\"<\/p>\n

\"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790\"<\/p>\n

\"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790\"<\/p>\n

4. \u7ed3\u8bba\u4e0e\u8ba8\u8bba<\/strong><\/p>\n

\u4ece\u672c\u6587\u7684\u5206\u6790\u53ef\u4ee5\u770b\u51fa\uff0cBTK\u6fc0\u9176\u662f\u4e00\u79cd\u65b9\u5174\u672a\u827e\u7684\u9776\u70b9\uff0c2014\u81f3\u4eca\u4ecd\u7136\u6709\u4e00\u5b9a\u6570\u91cf\u7684\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff0c\u800c\u4e14\u968f\u7740\u65b0\u7ed3\u6784\u7684\u5f00\u53d1\uff0c\u76f8\u4fe1\u672a\u6765\u7684\u51e0\u5e74\u5185\u4f1a\u6709\u6570\u79cdBTK\u6fc0\u9176\u6291\u5236\u5242\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/p>\n

\n

\"\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242PCT\u5316\u5408\u7269\u4e13\u5229\u5206\u6790\"<\/p>\n<\/section>\n

\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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