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14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">PARP\u6291\u5236\u5242\u5df2\u4e0a\u5e02\u53ca\u5728\u4e34\u5e8a\u7684\u56fd\u5916\u4ea7\u54c1\u5206\u6790<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537166925.jpeg\" alt=\"\u5012\u8ba1\u65f6\uff1a\u7ed9\u80bf\u7624\u7ec6\u80de\u4e0b\u5957\u7684PARP\u6291\u5236\u5242\u6765\u4e86\" title=\"\u5012\u8ba1\u65f6\uff1a\u7ed9\u80bf\u7624\u7ec6\u80de\u4e0b\u5957\u7684PARP\u6291\u5236\u5242\u6765\u4e86\"  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">\u76ee\u524d\u5df2\u6709\u4e09\u79cdPARP\u6291\u5236\u5242\u4e0a\u5e02\uff0c\u5206\u522b\u4e3a\uff1a\u963f\u65af\u5229\u5eb7\u7684Lynparza\uff08Olaparib, \u5965\u62c9\u5e15\u5229\uff09\u3001Clovis\u7684Rubraca\uff08Rucaparib, \u5362\u5361\u5e15\u5c3c\uff09\u3001TESARO\u548c\u9ed8\u6c99\u4e1c\u7684Zejula\uff08Niraparib, \u5c3c\u62c9\u5e15\u5c3c\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\"><strong>1<\/strong><strong>\uff09Lynparza<\/strong><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">Lynparza\uff08Olaparib, \u5965\u62c9\u5e15\u5229\uff09\u4e8e2014\u5e7412\u670819\u65e5\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u9002\u7528\u4e8e\u4e2a\u4f53\u9057\u4f20\u57fa\u56e0\u578b\u4e2d\u5177\u6709BRCA\u57fa\u56e0\u7f3a\u9677\u7a81\u53d8\uff0c\u4e14\u8fd9\u4e9b\u60a3\u8005\u81f3\u5c11\u7ecf\u8fc7\u65e2\u5f803\u7ebf\u5316\u7597\u30022017\u5e748\u670817\u65e5\u7f8e\u56fdFDA\u589e\u52a0\u6279\u51c6\u4e86\u5965\u62c9\u5e15\u5229\u7528\u4e8e\u5bf9\u6700\u8fd1\u4e00\u6b21\u542b\u94c2\u5316\u7597\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u7684\u590d\u53d1\u6027\u60a3\u8005\u7684\u7ef4\u6301\u6cbb\u7597\uff08\u4e0eZejula\u540c\u4e00\u9002\u5e94\u75c7\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">\u6839\u636e\u836f\u7269\u7efc\u5408\u6570\u636e\u5e93\uff08PDB, http:\/\/pdb.pharmadl.com\uff09\u663e\u793a\uff0c\u81ea2014\u5e74Lynparza\u4e0a\u5e02\u4ee5\u6765\uff0c\u5168\u7403\u9500\u552e\u989d\u4ece\u4e0d\u5230100\u4e07\u7f8e\u5143\u589e\u957f\u5230\u4e862.16\u4ebf\u7f8e\u5143\uff0c\u590d\u5408\u589e\u957f\u7387\u5c06\u8fd1200%\uff0c\u5e02\u573a\u589e\u957f\u8fc5\u731b\u3002<span style=\"caret-color: red;\">&nbsp;<\/span><\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537166926.jpg\" alt=\"\u5012\u8ba1\u65f6\uff1a\u7ed9\u80bf\u7624\u7ec6\u80de\u4e0b\u5957\u7684PARP\u6291\u5236\u5242\u6765\u4e86\" title=\"\u5012\u8ba1\u65f6\uff1a\u7ed9\u80bf\u7624\u7ec6\u80de\u4e0b\u5957\u7684PARP\u6291\u5236\u5242\u6765\u4e86\"  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\"><strong>2<\/strong><strong>\uff09Rubraca<\/strong><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">2016\u5e7412\u670819\u65e5\uff0cFDA\u52a0\u901f\u6279\u51c6\u4e86Clovis\u65b0\u836fRubraca\uff08Rucaparib, \u5362\u5361\u5e15\u5c3c\uff09\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u643a\u5e26\u6709\u5bb3BRCA\u7a81\u53d8\uff08\u751f\u6b96\u7cfb\u548c\/\u6216\u4f53\u7ec6\u80de\uff09\u7684\u665a\u671f\u5375\u5de2\u764c\uff0c\u8fd9\u4e9b\u60a3\u8005\u5df2\u7ecf\u63a5\u53d7\u8fc7\u4e24\u79cd\u6216\u66f4\u591a\u79cd\u5316\u7597\u6cbb\u7597\u624b\u6bb5\u3002FDA\u8fd8\u66fe\u6388\u4e88Rubraca\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u548c\u4f18\u5148\u5ba1\u67e5\u8d44\u683c\uff0c\u540c\u65f6\u4e5f\u83b7\u5f97\u4e86\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\"><strong>3<\/strong><strong>\uff09Zejula<\/strong><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">2017\u5e743\u670828\u65e5\u7b2c\u4e09\u4e2aPARP\u6291\u5236\u5242\u83b7FDA\u6279\u51c6\uff0c\u5373TESARO\u548c\u9ed8\u6c99\u4e1c\u7684Zejula\uff08Niraparib, 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15px;\">\u4e09\u3001PARP\u6291\u5236\u5242\u5bf9\u6211\u56fd\u7684\u610f\u4e49<\/span><\/strong><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">\u76ee\u524d\uff0c\u56fd\u5185\u5bf9PARP\u6291\u5236\u5242\u7814\u7a76\u7684\u4f01\u4e1a\u548c\u5b66\u672f\u673a\u6784\u4e5f\u975e\u5e38\u591a\uff0c\u8fdb\u5165\u4e34\u5e8a\u7684\u5305\u62ec\u767e\u6d4e\u795e\u5dde\u7684BGB290\uff0c\u6052\u745e\u7684Fluzoparib\u7b49\uff0c\u9700\u8981\u6307\u51fa\u7684\u662f\u4e0d\u540c\u7ed3\u6784\u7684PARP\u6291\u5236\u5242\u7597\u6548\u548c\u4f5c\u7528\u673a\u5236\u5dee\u522b\u53ef\u80fd\u4f1a\u7279\u522b\u5927\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537166927.jpg\" alt=\"\u5012\u8ba1\u65f6\uff1a\u7ed9\u80bf\u7624\u7ec6\u80de\u4e0b\u5957\u7684PARP\u6291\u5236\u5242\u6765\u4e86\" title=\"\u5012\u8ba1\u65f6\uff1a\u7ed9\u80bf\u7624\u7ec6\u80de\u4e0b\u5957\u7684PARP\u6291\u5236\u5242\u6765\u4e86\"  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\"><span style=\"caret-color: red;\">PARP\u6291\u5236\u5242\u4e0d\u662f\u76ee\u524d\u72b6\u6001\u706b\u70ed\u7684\u9776\u5411\u5c0f\u5206\u5b50\uff0c\u8be5\u7c7b\u5206\u5b50\u5bf9\u6709BRCA\u57fa\u56e0\u7f3a\u9677\u7684\u665a\u671f\u5375\u5de2\u764c\u60a3\u8005\u7597\u6548\u786e\u5207\uff0c\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u4e0e\u764c\u75c7\u4e2a\u4f53\u5316\u6cbb\u7597\u7684\u5927\u65b9\u5411\u543b\u5408\u3002\u5f88\u591a\u5236\u836f\u5de8\u5934\u88abPARP\u6291\u5236\u5242\u201c\u4f24\u7684\u592a\u6df1\u201d\uff0c\u7136\u800c\u73b0\u5728PARP\u6291\u5236\u5242\u6210\u4e3a\u5f88\u591a\u91ce\u5fc3\u52c3\u52c3\u7684\u5c0f\u516c\u53f8\u7684\u91cd\u70b9\u7814\u53d1\u65b9\u5411\u3002\u867d\u7136PARP\u6291\u5236\u5242\u901a\u5e38\u4e0eBRCA<\/span><sub style=\"caret-color: red;\">1<\/sub><span style=\"caret-color: red;\">\u6216BRCA<\/span><sub style=\"caret-color: red;\">2<\/sub><span style=\"caret-color: red;\">\u79cd\u7cfb\u57fa\u56e0\u7a81\u53d8\u8054\u7cfb\u5728\u4e00\u8d77\uff0c\u4f46\u6709\u671b\u62d3\u5c55\u5230\u5176\u4ed6\u539f\u56e0\u5bfc\u81f4\u7684HRR\u7f3a\u9677\u80bf\u7624\u4e2d\u3002\u4e3a\u6b64\uff0c\u5bfb\u627e\u65b0\u7684HRR\u7f3a\u9677\u76f8\u5173\u7684\u751f\u7269\u6807\u8bb0\u7269\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/span><\/span><\/p>\n<section class=\"\"  style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img      class=\"\"  style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;letter-spacing: 0.544px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537166927.jpeg\" alt=\"\u5012\u8ba1\u65f6\uff1a\u7ed9\u80bf\u7624\u7ec6\u80de\u4e0b\u5957\u7684PARP\u6291\u5236\u5242\u6765\u4e86\" title=\"\u5012\u8ba1\u65f6\uff1a\u7ed9\u80bf\u7624\u7ec6\u80de\u4e0b\u5957\u7684PARP\u6291\u5236\u5242\u6765\u4e86\"  \/><\/p>\n<\/section>\n<p style=\"font-size: 16px;white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6839\u636e\u4e2d\u56fd\u65b0\u836f\u7814\u53d1\u76d1\u6d4b\u6570\u636e\u5e93\uff08CPM, http:\/\/cpm.pharmadl.com\uff09\u663e\u793a\uff0c\u963f\u65af\u5229\u5eb7\u5965\u62c9\u5e15\u5229\u7247 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":40972,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/40971"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=40971"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/40971\/revisions"}],"predecessor-version":[{"id":40977,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/40971\/revisions\/40977"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/40972"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=40971"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=40971"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=40971"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}