{"id":41079,"date":"2018-08-10T01:00:00","date_gmt":"2018-09-17T06:50:00","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/pd-1%e7%8b%bc%e7%83%9f%e5%9b%9b%e8%b5%b7%ef%bc%8cpd-l1%e6%88%96%e6%88%90%e6%88%91%e5%9b%bd%e5%bc%af%e9%81%93%e8%b6%85%e8%bd%a6%e6%96%b0%e6%9c%ba%e9%81%87\/"},"modified":"2018-09-17T14:50:05","modified_gmt":"2018-09-17T06:50:05","slug":"pd-1%e7%8b%bc%e7%83%9f%e5%9b%9b%e8%b5%b7%ef%bc%8cpd-l1%e6%88%96%e6%88%90%e6%88%91%e5%9b%bd%e5%bc%af%e9%81%93%e8%b6%85%e8%bd%a6%e6%96%b0%e6%9c%ba%e9%81%87","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/41079\/","title":{"rendered":"PD-1\u72fc\u70df\u56db\u8d77\uff0cPD-L1\u6216\u6210\u6211\u56fd\u5f2f\u9053\u8d85\u8f66\u65b0\u673a\u9047"},"content":{"rendered":"
\n
\n
\n
\n

\u6839\u636e\u4e2d\u56fd\u65b0\u836f\u7814\u53d1\u76d1\u6d4b\u6570\u636e\u5e93\uff08CPM, http:\/\/cpm.pharmadl.com\uff09\u663e\u793a\uff0c\u76ee\u524d\u56fd\u5185\u4ec5\u6709PD-1\u83b7\u6279\u8fdb\u53e3\uff0c\u6682\u65e0PD-L1\u4e0a\u5e02\uff0cPD-L1\u6216\u6210\u6211\u56fd\u5f2f\u9053\u8d85\u8f66\u65b0\u673a\u9047\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 \u5168\u65871844\u5b57\uff0c\u7528\u65f64\u5206\u949f<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4f5c\u8005\uff1a\u6d2a\u6770<\/p>\n

\n

\u6839\u636e\u56fd\u5bb6\u764c\u75c7\u4e2d\u5fc3\u6240\u53d1\u5e03\u300a2018\u5e74\u4e2d\u56fd\u764c\u75c7\u6570\u636e\u62a5\u544a\u300b\u663e\u793a\uff0c\u4e2d\u56fd\u6bcf\u5929\u7ea6\u67091\u4e07\u4eba\u786e\u8bca\u764c\u75c7\u3002\u6211\u56fd\u764c\u75c7\u7684\u53d1\u75c5\u7387\u4e3a278.07\/10\u4e07\uff0c\u51e0\u4e4e\u662f\u56fd\u9645\u6c34\u5e73\u7684\u4e00\u500d\u3002<\/p>\n

\u6211\u56fd2016\u5e74\u516c\u5e03\u7684\u201c\u5065\u5eb7\u4e2d\u56fd2030\u201d\u8ba1\u5212\uff0c\u76ee\u6807\u662f\u4ece2015\u5e74\u52302030\u5e74\u5c06\u4e3b\u8981\u975e\u4f20\u67d3\u6027\u75be\u75c5\u5f15\u8d77\u7684\u6b7b\u4ea1\u7387\u964d\u4f4e30%\u3002\u56e0\u6b64\uff0c\u63d0\u9ad8\u764c\u75c7\u7684\u9884\u9632\u548c\u63a7\u5236\u5bf9\u5b9e\u73b0\u8fd9\u4e00\u8ba1\u5212\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n

\u4e00\u3001PD-1\/PD-L1\u6982\u8ff0<\/strong><\/p>\n

\u8fd1\u5e74\u6765\uff0c\u5728\u80bf\u7624\u6cbb\u7597\u9886\u57df\u6700\u88ab\u5bc4\u4e88\u539a\u671b\u7684\u5f53\u5c5e\u514d\u75ab\u7597\u6cd5\u3002\u5373\u662f\u6307\u5229\u7528\u4eba\u4f53\u514d\u75ab\u673a\u5236\uff0c\u901a\u8fc7\u4e3b\u52a8\u6216\u88ab\u52a8\u7684\u65b9\u6cd5\u6765\u589e\u5f3a\u60a3\u8005\u514d\u75ab\u529f\u80fd\uff0c\u8fbe\u5230\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u7684\u76ee\u7684\u3002\u6700\u5f15\u4eba\u77a9\u76ee\u7684\u4fbf\u662fPD1\/PDL1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u6297PD\u7c7b\u7684\u836f\u7269\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5f00\u8f9f\u4e86\u5168\u65b0\u7684\u6cbb\u7597\u601d\u8def\u3002<\/p>\n

\u53ef\u4ee5\u5c06PD-1\/PD-L1\u901a\u8def\u7406\u89e3\u4e3a\u4e00\u7ec4\u63a5\u5934\u6697\u53f7\u3002\u5176\u4e2d\uff0c\u6d3b\u5316T\u7ec6\u80de\u7684\u5c0f\u5175PD-1\u558a\u8bdd\u201c\u5929\u738b\u76d6\u5730\u864e\u201d\uff0c\u5176\u5b83\u6709PD-L1\u7684\u7ec6\u80de\u56de\u590d\u201c\u5b9d\u5854\u9547\u6cb3\u5996\u201d\uff0c\u5bf9\u63a5\u6210\u529f\uff0c\u5219\u76f8\u5b89\u65e0\u4e8b\u3002\u8fd9\u672c\u6765\u662f\u4eba\u4f53\u7684\u4e00\u79cd\u81ea\u6211\u4fdd\u62a4\u7684\u673a\u5236\uff0c\u4f46\u4e0d\u77e5\u600e\u4e48\u7684\uff0c\u80bf\u7624\u7ec6\u80de\u4e5f\u5077\u5b66\u4e86\u6697\u53f7\uff0c\u5b83\u5728\u9047\u89c1T\u7ec6\u80de\u65f6\u4e5f\u80fd\u558a\u51fa\u201c\u5b9d\u5854\u9547\u6cb3\u5996\u201d\uff0c\u8499\u853d\u4e86T\u7ec6\u80de\u3002\u6700\u540e\u907f\u514d\u4e86\u88ab\u514d\u75ab\u7ec6\u80de\u653b\u51fb\u7684\u547d\u8fd0\u3002\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0cPD-1\/PD-L1\u514d\u75ab\u7597\u6cd5\u5c31\u51fa\u6765\u5e2e\u5fd9\u4e86\uff0c\u5b83\u4f7f\u7528\u836f\u7269\u5c01\u4f4f\u901a\u8def\uff0c\u5982\u6b64\u4e00\u6765\uff0c\u5373\u4f7f\u80bf\u7624\u7ec6\u80de\u77e5\u9053\u6697\u8bed\u4e5f\u65e0\u8ba1\u53ef\u65bd\uff0c\u53ea\u80fd\u88ab\u5f53\u6210\u201c\u5f02\u7aef\u201d\u63a5\u53d7\u514d\u75ab\u7ec6\u80de\u7684\u653b\u51fb\u4e86\u3002<\/p>\n

\u622a\u6b62\u76ee\u524d\uff0cFDA\u8bb8\u53ef\u7684PD-1\u6291\u5236\u5242\u51712\u4e2a\u5206\u522b\u4e3aKeytruda\uff08\u5e15\u535a\u5229\u73e0\u5355\u6297, pembrolizumab\uff09\u548cOpdivo\uff08\u5c3c\u4f0f\u5355\u6297, nivolumab\uff09\u3002PD-L1\u6291\u5236\u5242\u5171\u67093\u4e2a\u5206\u522b\u4e3aTecentriq\uff08\u963f\u66ff\u73e0\u5355\u6297, atezolizumab\uff09\u3001Bavencio\uff08\u963f\u7ef4\u5355\u6297, avelumab\uff09\u548cImfinzi\uff08\u5ea6\u4f10\u5355\u6297, durvalumab\uff09\u3002<\/p>\n

\u5176\u4e2d\uff0c\u57282018\u5e746\u670815\u65e5Opdivo\u7387\u5148\u901a\u8fc7CFDA\u6279\u51c6\u8fdb\u53e3\u6ce8\u518c\u7533\u8bf7\uff0c\u6210\u4e3a\u7b2c\u4e00\u4e2a\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684PD-1\u6291\u5236\u5242\u3002\u800c\u7ee76\u6708\u540e\u76847\u670825\u65e5\uff0cKeytruda\u53c8\u83b7\u6279\u5728\u4e2d\u56fd\u5927\u9646\u4e0a\u5e02\uff0c\u9488\u5bf9\u7684\u662f\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u76ee\u524d\u5e02\u9762\u4e0a\u5b58\u5728\u7684PD-1\u6291\u5236\u5242\u5df2\u7ecf\u5168\u90e8\u5728\u56fd\u5185\u4e0a\u5e02\uff0c\u800cPD-L1\u5728\u56fd\u5185\u6682\u65e0\u4e00\u4e2a\u4ea7\u54c1\u83b7\u6279\u3002<\/p>\n

\u4e8c\u3001\u76ee\u524d\u4e0a\u5e02\u7684PD-1\/PD-L1\u836f\u7269\u5206\u6790<\/strong><\/p>\n

Keytruda<\/strong><\/p>\n

2014\u5e749\u67084\u65e5\uff0cFDA\u6279\u51c6\u9ed8\u6c99\u4e1cKeytruda\u7528\u4e8e\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u7684\u9ed1\u8272\u7d20\u7624\uff0c\u662fFDA\u6279\u51c6\u7684\u9996\u4e2aPD-1\u6291\u5236\u5242\u3002\u76ee\u524d\uff0c\u4ece\u5168\u7403\u8303\u56f4\u83b7\u6279\u9002\u5e94\u75c7\u6570\u91cf\u800c\u8a00\uff0cKeytruda\u836f\u662f\u76ee\u524d\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u7624\u79cd\u6700\u5e7f\u6cdb\u7684\u514d\u75ab\u836f\u7269\u3002\u5b83\u5df2\u572880\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u4f7f\u7528\uff0c\u8986\u76d6\u4e869\u4e2a\u7624\u79cd\u768410\u4e2a\u4ee5\u4e0a\u9002\u5e94\u75c7\uff0c\u5305\u62ec\u9ed1\u8272\u7d20\u7624\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u5934\u9888\u764c\uff0c\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u8180\u80f1\u764c\uff0c\u5bab\u9888\u764c\u7b49\u3002<\/p>\n

\"PD-1\u72fc\u70df\u56db\u8d77\uff0cPD-L1\u6216\u6210\u6211\u56fd\u5f2f\u9053\u8d85\u8f66\u65b0\u673a\u9047\"<\/p>\n

\u6839\u636e\u836f\u7269\u7efc\u5408\u6570\u636e\u5e93\uff08PDB, http:\/\/pdb.pharmadl.com\uff09\u663e\u793a\uff0c\u81ea2014\u5e74Keytruda\u4e0a\u5e02\u4ee5\u6765\uff0c\u5168\u7403\u9500\u552e\u989d\u4ece5000\u4e07\u7f8e\u5143\u589e\u957f\u5230\u4e8636\u4ebf\u7f8e\u5143\uff0c\u590d\u5408\u589e\u957f\u7387\u8d85\u8fc7300%\uff0c\u5e02\u573a\u589e\u957f\u8fc5\u731b\u3002<\/p>\n

\"PD-1\u72fc\u70df\u56db\u8d77\uff0cPD-L1\u6216\u6210\u6211\u56fd\u5f2f\u9053\u8d85\u8f66\u65b0\u673a\u9047\"<\/p>\n

Opdivo<\/strong><\/p>\n

2014\u5e74\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684Opdivo\uff08Nivolumab\uff09\u5728\u65e5\u672c\u88ab\u6279\u51c6\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u57282014\u5e74\u5e95\u88abFDA\u63d0\u524d\u4e09\u4e2a\u591a\u6708\u52a0\u901f\u6279\u51c6\u7528\u4e8e\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u30022015\u5e74FDA\u6269\u5927\u5176\u9002\u5e94\u75c7\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u3002\u622a\u6b62\u76ee\u524d\uff0cOpdivo\u5728\u5168\u7403\u5df2\u7ecf\u83b7\u6279\u4e5d\u5927\u80bf\u7624\u9002\u5e94\u75c7\uff0c\u5206\u522b\u662f\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u5934\u9888\u90e8\u9cde\u764c\u3001\u80be\u7ec6\u80de\u764c\u3001\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u80c3\u764c\u3001\u809d\u7ec6\u80de\u764c\u3002<\/p>\n

\"PD-1\u72fc\u70df\u56db\u8d77\uff0cPD-L1\u6216\u6210\u6211\u56fd\u5f2f\u9053\u8d85\u8f66\u65b0\u673a\u9047\"<\/p>\n

\u6839\u636e\u836f\u7269\u7efc\u5408\u6570\u636e\u5e93\uff08PDB, http:\/\/pdb.pharmadl.com\uff09\u663e\u793a\uff0c\u81ea2014\u5e74Opdivo\u4e0a\u5e02\u4ee5\u6765\uff0c\u5168\u7403\u9500\u552e\u989d\u4ece980\u4e07\u7f8e\u5143\u589e\u957f\u5230\u5c06\u8fd155\u4ebf\u7f8e\u5143\uff0c\u590d\u5408\u589e\u957f\u7387\u8d85\u8fc7720%\u3002<\/p>\n

\"PD-1\u72fc\u70df\u56db\u8d77\uff0cPD-L1\u6216\u6210\u6211\u56fd\u5f2f\u9053\u8d85\u8f66\u65b0\u673a\u9047\"<\/p>\n

Tecentriq<\/strong><\/p>\n

\u7f57\u6c0f\u7684Tecentriq\uff08Atezolizumab\uff09\u4e8e2016\u5e745\u6708\u83b7\u6279\u7528\u4e8e\u5c3f\u8def\u4e0a\u76ae\u764c\uff08\u8180\u80f1\u764c\uff09\uff0c\u662f\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7684PD-L1\u6291\u5236\u5242\u30022016\u5e7410\u6708\u53c8\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u9776\u5411\u836f\u3001\u5316\u7597\u5931\u8d25\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002<\/p>\n

\u6839\u636e\u836f\u7269\u7efc\u5408\u6570\u636e\u5e93\uff08PDB, http:\/\/pdb.pharmadl.com\uff09\u663e\u793a\uff0cTecentriq\u4e0a\u5e027\u4e2a\u6708\u9500\u552e\u989d\u5c31\u8fbe1.45\u4ebf\u7f8e\u5143\uff0c2017\u5e74\u7684\u9500\u552e\u8fbe4.62\u4ebf\u7f8e\u5143\uff0c\u589e\u957f\u7387\u8d85\u8fc7200%\u3002<\/p>\n

\"PD-1\u72fc\u70df\u56db\u8d77\uff0cPD-L1\u6216\u6210\u6211\u56fd\u5f2f\u9053\u8d85\u8f66\u65b0\u673a\u9047\"<\/p>\n

Bavencio<\/strong><\/p>\n

2017\u5e743\u6708\uff0c\u8f89\u745e\u548c\u9ed8\u514b\u7684Bavencio\uff08avelumab\uff09\u4ee5\u4f18\u5148\u5ba1\u8bc4\u7684\u65b9\u5f0f\u83b7\u5f97FDA\u52a0\u901f\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u759712\u5c81\u4ee5\u4e0a\u9752\u5c11\u5e74\u53ca\u6210\u4eba\u8f6c\u79fb\u6027\u9ed8\u514b\u5c14\u7ec6\u80de\u764c\u60a3\u8005\u3002Bavencio\u83b7\u5f97\u8fc7FDA\u6388\u4e88\u7684\u7a81\u7834\u6027\u836f\u7269\u8d44\u683c\uff0c\u662f\u5168\u7403\u7b2c4\u4e2a\u4e0a\u5e02\u7684PD-1\/PD-L1\u7c7b\u836f\u7269\uff0c\u4e5f\u662f\u7b2c\u4e00\u4e2a\u83b7\u6279\u6cbb\u7597\u8f6c\u79fb\u6027\u9ed8\u514b\u5c14\u7ec6\u80de\u764c\u7684PD-L1\u5355\u6297\u3002<\/p>\n

Imfinzi<\/strong><\/p>\n

2017\u5e745\u6708\uff0cFDA\u52a0\u901f\u6279\u51c6\u4e86\u963f\u65af\u5229\u5eb7\u751f\u4ea7\u7684Imfinzi\uff08Durvalumab\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u5728\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u4e4b\u540e\u6216\u5728\u542b\u94c2\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u5316\u759712\u4e2a\u6708\u4e4b\u5185\u75c5\u60c5\u6076\u5316\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u3002\u662f\u4e00\u79cd\u76f4\u63a5\u9776\u5411PD-L1\u7684\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u4ee5\u963b\u65adPD-L1\u4e0eT\u7ec6\u80de\u4e0a\u7684PD-1\u548cCD80\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

\u4e09\u3001\u56fd\u5185PD-1\/PD-L1\u7814\u7a76\u73b0\u72b6<\/span><\/strong><\/p>\n

PD-1\/PD-L1\u7531\u4e8e\u7597\u6548\u786e\u5207\uff0c\u540c\u65f6\u517c\u5907\u5e7f\u8c31\u6027\u3001\u4f4e\u6bd2\u6027\u7b49\u7279\u70b9\uff0c\u5438\u5f15\u4e86\u8bf8\u591a\u56fd\u5185\u5927\u578b\u836f\u4f01\uff0c\u5f62\u6210\u4e86\u6052\u745e\u533b\u836f\u3001\u541b\u5b9e\u751f\u7269\u3001\u767e\u6d4e\u795e\u5dde\u3001\u4fe1\u8fbe\u751f\u7269\u7684\u7ade\u4e89\u683c\u5c40\u3002<\/span><\/p>\n

\u6839\u636e\u4e2d\u56fd\u65b0\u836f\u7814\u53d1\u76d1\u6d4b\u6570\u636e\u5e93\uff08CPM, http:\/\/cpm.pharmadl.com\uff09\u53ef\u77e5\uff0c\u4ece\u4e34\u5e8a\u6570\u636e\u7684\u91cf\u6765\u770b\uff0c\u541b\u5b9e\u751f\u7269\u5728\u56fd\u5185\u5f00\u5c55\u4e34\u5e8a\u6b21\u6570\u6700\u591a\uff1b\u4ece\u7533\u62a5\u60c5\u51b5\u6765\u770b\uff0c\u4e0a\u8ff04\u5bb6\u4f01\u4e1a\u5728\u7814\u7684\u5168\u90e8\u4e3aPD-1\uff0c\u6682\u65e0PD-L1\uff0c\u5176\u4e2d\u63d0\u4ea4PD-1\u4e0a\u5e02\u7533\u8bf7\u7684\u4f01\u4e1a\u5206\u522b\u4e3a\u541b\u5b9e\u751f\u7269\u3001\u4fe1\u8fbe\u751f\u7269\u548c\u6052\u745e\u533b\u836f\uff0c\u6709\u671b\u57282019\u5e74\u524d\u540e\u83b7\u6279\u4e0a\u5e02\u3002\u53e6\u5916\uff0c\u9664\u4e0a\u8ff04\u5bb6\u836f\u4f01\u5916\uff0c\u8fd8\u6709\u8d85\u8fc710\u5bb6\u836f\u4f01\u6b63\u6b63\u5728\u5f00\u5c55PD-1\/PD-L1\u5355\u6297\u7533\u62a5\u6216\u4e34\u5e8a\u8bd5\u9a8c\u5de5\u4f5c\u3002<\/span><\/p>\n

\u53ef\u4ee5\u770b\u51fa\uff0c\u4e0d\u8bba\u662f\u56fd\u5185\u8fd8\u662f\u56fd\u5916\u4f01\u4e1a\uff0c\u5bf9PD-1\u7684\u4e34\u5e8a\u7814\u7a76\u5df2\u7ecf\u975e\u5e38\u6df1\u5165\uff0cPD-1\u201c\u4e24\u5927\u5de8\u5934\u201dKeytruda\u548cOpdivo\u5df2\u7ecf\u8986\u76d6\u4e86\u6570\u5341\u4e2a\u9002\u5e94\u75c7\uff0c\u867d\u7136\u4ecd\u6709\u589e\u52a0\u4f46\u662f\u5e45\u5ea6\u5fc5\u5b9a\u4f1a\u5927\u5e45\u4e0b\u964d\uff0c\u800c\u5bf9PD-L1\u7684\u7814\u7a76\u4ecd\u5904\u4e8e\u8d77\u6b65\u9636\u6bb5\uff0c\u76ee\u524d\u4ec5\u8986\u76d6\u90e8\u5206\u53d1\u75c5\u7387\u8f83\u4f4e\u7684\u75be\u75c5\uff0c\u672a\u6765\u7814\u53d1\u7a7a\u95f4\u5de8\u5927\uff0c\u6216\u6210\u6211\u56fd\u5f2f\u9053\u8d85\u8f66\u65b0\u673a\u9047\u3002<\/span><\/p>\n

\"PD-1\u72fc\u70df\u56db\u8d77\uff0cPD-L1\u6216\u6210\u6211\u56fd\u5f2f\u9053\u8d85\u8f66\u65b0\u673a\u9047\"<\/p>\n<\/section>\n

\n

\"PD-1\u72fc\u70df\u56db\u8d77\uff0cPD-L1\u6216\u6210\u6211\u56fd\u5f2f\u9053\u8d85\u8f66\u65b0\u673a\u9047\"<\/p>\n<\/section>\n

\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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