{"id":41125,"date":"2018-08-09T01:00:00","date_gmt":"2018-09-17T06:50:33","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e9%9d%9e%e9%9c%8d%e5%a5%87%e9%87%91%e6%b7%8b%e5%b7%b4%e7%98%a4%e5%8f%88%e8%8e%b7%e4%b8%80%e7%aa%81%e7%a0%b4%e6%80%a7%e8%8d%af%e7%89%a9%ef%bc%81\/"},"modified":"2018-09-17T14:50:36","modified_gmt":"2018-09-17T06:50:36","slug":"%e9%9d%9e%e9%9c%8d%e5%a5%87%e9%87%91%e6%b7%8b%e5%b7%b4%e7%98%a4%e5%8f%88%e8%8e%b7%e4%b8%80%e7%aa%81%e7%a0%b4%e6%80%a7%e8%8d%af%e7%89%a9%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/41125\/","title":{"rendered":"\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u53c8\u83b7\u4e00\u7a81\u7834\u6027\u836f\u7269\uff01"},"content":{"rendered":"
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\u6839\u636e\u4e2d\u56fd\u65b0\u836f\u7814\u53d1\u76d1\u6d4b\u6570\u636e\u5e93\uff08CPM\uff09<\/span><\/span><\/span><\/span><\/span>\u663e\u793a\uff0c\u534f\u548c\u53d1\u9175\u9e92\u9e9f\u682a\u5f0f\u4f1a\u793e\u7684Poteligeo\u5728\u4eca\u5929\u901a\u8fc7\u4e86\u7f8e\u56fdFDA\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u548c\u4f18\u5148\u5ba1\u8bc4\u3002<\/span><\/span><\/span><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 \u5168\u65871705\u5b57\uff0c\u7528\u65f63\u5206\u949f<\/span><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4f5c\u8005\uff1a\u6d2a\u6770<\/p>\n

\n
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\u6839\u636e\u4e2d\u56fd\u65b0\u836f\u7814\u53d1\u76d1\u6d4b\u6570\u636e\u5e93\uff08CPM\uff09\u663e\u793a\uff0c\u534f\u548c\u53d1\u9175\u9e92\u9e9f\u682a\u5f0f\u4f1a\u793e\u7684Poteligeo\uff08mogamulizumab\uff09\u5728\u4eca\u5929\u901a\u8fc7\u4e86\u7f8e\u56fdFDA\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u548c\u4f18\u5148\u5ba1\u8bc4\u3002\u9002\u5e94\u75c7\u4e3a\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u6b21\u5168\u8eab\u6027\u7597\u6cd5\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u8548\u6837\u771f\u83cc\u75c5\uff08mycosis fugoides, MF\uff09\u6216\u585e\u624e\u91cc\u7efc\u5408\u75c7\uff08Sezary syndrome, SS\uff09\u6210\u5e74\u60a3\u8005\u3002<\/p>\n

\u5728\u4f17\u591a\u7c7b\u578b\u7684\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u4e2d\uff0c\u6709\u4e00\u79cd\u4e9a\u578b\u53eb\u505a\u76ae\u80a4T\u7ec6\u80de\u6dcb\u5df4\u7624\u3002\u5176\u4e2d\uff0cMF\u4e0eSS\u662f\u8fd9\u79cd\u75be\u75c5\u6700\u4e3a\u5e38\u89c1\u7684\u4e24\u79cd\u7c7b\u578b\u3002\u60a3\u8005\u7684\u76ae\u80a4\u4e0a\u4f1a\u6709\u6807\u5fd7\u6027\u7684\u6076\u6027T\u6dcb\u5df4\u7ec6\u80de\u51fa\u73b0\u3002\u968f\u7740\u75c5\u60c5\u7684\u63a8\u79fb\uff0c\u8fd9\u79cd\u75be\u75c5\u6700\u7ec8\u53ef\u80fd\u4f1a\u5f71\u54cd\u5230\u76ae\u80a4\u3001\u8840\u6db2\u3001\u6dcb\u5df4\u7ed3\u3001\u4ee5\u53ca\u810f\u5668\u3002<\/p>\n

\u4e00\u3001MF\/SS\u6d41\u884c\u75c5\u5b66<\/strong><\/p>\n

\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u662f\u7531\u4e8e\u6dcb\u5df4\u7ec6\u80de\u764c\u53d8\u5bfc\u81f4\u7684\u764c\u75c7\u3002\u5728\u6211\u56fd\u5176\u53d1\u75c5\u7387\u8fdc\u9ad8\u4e8e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002\u5176\u4e2d\uff0c\u8548\u6837\u771f\u83cc\u75c5\uff08mycosis fungoides, MF\uff09\u548c\u585e\u624e\u91cc\u7efc\u5408\u75c7\uff08Sezary\u2019s syndrome, SS\uff09\u662f\u764c\u53d8\u6dcb\u5df4\u7ec6\u80de\u5f71\u54cd\u76ae\u80a4\u7684\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7c7b\u578b\u3002SS\u4e3aMF\u7684\u7ea2\u76ae\u75c5\u4e9a\u578b\uff0c\u5360\u539f\u53d1\u6027\u76ae\u80a4\u6dcb\u5df4\u7624\u768475%\u3002MF\/SS\u662f\u6700\u5e38\u89c1\u7684\u7c7b\u578b\uff0c\u7ea6\u5360\u6240\u6709\u76ae\u80a4\u6076\u6027\u6dcb\u5df4\u7624\u768450%\u5de6\u53f3\uff0c\u5176\u4ed6\u7c7b\u578b\u7684T\u7ec6\u80de\u6dcb\u5df4\u7624\u7ea6\u536025%\uff0c\u5305\u62ecCD30\u3001CD30-\u7684\u5927T\u7ec6\u80de\u6dcb\u5df4\u7624\u548c\u591a\u5f62\u6027\u5c0f\u4e2dT\u7ec6\u80de\u6dcb\u5df4\u7624\u3002<\/p>\n

\u4e8c\u3001Poteligeo\u5e02\u573a\u5206\u6790<\/strong><\/p>\n

Poteligeo\uff08mogamulizumab\uff09\u662f\u534f\u548c\u53d1\u9175\u9e92\u9e9f\u682a\u5f0f\u4f1a\u793e\u7814\u53d1\u7684\u4eba\u6e90\u5316CC\u8d8b\u5316\u56e0\u5b50\u53d7\u4f534\uff08CCR4\uff09\u5355\u514b\u9686\u6297\u4f53\u3002CCR4\u5c5e\u4e8e\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u5bb6\u65cf\uff0c\u5df2\u77e5\u662f2\u4e2a\u8d8b\u5316\u56e0\u5b50CCL12\u548cCCL17\u7684\u53d7\u4f53\uff0c\u4e3b\u8981\u8868\u8fbe\u4e8e\u8c03\u8282T\u7ec6\u80de\u548c\u8f85\u52a9T\u7ec6\u80de\u4e0a\u7684G\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCR\uff09\u3002<\/strong><\/p>\n

\u56fe\u88681CCR4\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n

\"\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u53c8\u83b7\u4e00\u7a81\u7834\u6027\u836f\u7269\uff01\"<\/p>\n

\u8d44\u6599\u6765\u6e90\uff1aPDB\uff0c\u4e2d\u56fd\u533b\u836f\u5de5\u4e1a\u4fe1\u606f\u4e2d\u5fc3<\/strong><\/p>\n

\u5728\u8c03\u8282\u6027T\u7ec6\u80de\u4e0a\u7684CCR4\u5728\u914d\u4f53\u7684\u523a\u6fc0\u4e0b\uff0c\u8c03\u63a7\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u4ece\u800c\u53c2\u4e0e\u8c03\u8282\u6027T\u7ec6\u80de\u5bf9\u673a\u4f53\u708e\u75c7\u53cd\u5e94\u7684\u63a7\u5236\u548c\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u6291\u5236\uff1b\u800c\u8fc7\u8868\u8fbe\u5728\u5916\u5468T\u7ec6\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\u7ec6\u80de\u4e0a\u7684CCR4\uff0c\u5219\u662f\u4e00\u4e2a\u7279\u5f02\u6027\u7684\u836f\u7269\u9776\u70b9\u3002<\/p>\n

\u56e0\u6b64\uff0c\u4ece\u7406\u8bba\u4e0a\u6765\u8bb2\uff0c\u4ee5CCR4\u4e3a\u9776\u70b9\u5f00\u53d1\u7684\u836f\u7269\u80fd\u591f\u901a\u8fc7\u963b\u65ad\u8868\u8fbe\u5728\u8c03\u8282\u6027T\u7ec6\u80de\u4e0a\u7684CCR4\u5b9e\u73b0\u5bf9\u673a\u4f53\u514d\u75ab\u75be\u75c5\u548c\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\uff0c\u5e76\u80fd\u591f\u901a\u8fc7\u9776\u5411\u8fc7\u8868\u8fbe\u5728\u5916\u5468T\u7ec6\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\u7ec6\u80de\u4e0a\u7684CCR4\u5b9e\u73b0\u5bf9\u764c\u7ec6\u80de\u7684\u7cbe\u786e\u6740\u4f24\u3002<\/p>\n

\u65e5\u672c\u534f\u548c\u53d1\u9175\u9e92\u9e9f\u9009\u62e9CCR4\u5f00\u53d1\u6297\u4f53\u836f\u7269\uff0c\u5e94\u5f53\u662f\u8003\u8651\u5230\u4e86T\u7ec6\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\uff08ATL\uff09\u5728\u65e5\u672c\u7684\u53d1\u75c5\u60c5\u5f62\u3002ATL\u7684\u4e3b\u8981\u53d1\u75c5\u539f\u56e0\u662fI\u578bT\u7ec6\u80de\u55dc\u6dcb\u5df4\u7ec6\u80de\u75c5\u6bd2\uff08HTLV-1\uff09\uff0c\u8fd9\u79cd\u75c5\u6bd2\u7684\u611f\u67d3\u4e3b\u8981\u5206\u5e03\u5728\u65e5\u672c\u897f\u5357\u90e8\u3001\u897f\u975e\u3001\u52a0\u52d2\u6bd4\u6d77\u7b49\u5730\u533a\u3002\u5728\u65e5\u672c\uff0c\u8fd9\u79cd\u75c5\u6bd2\u7684\u643a\u5e26\u8005\u4f30\u8ba1\u8fbe100\u4e07\u4ee5\u4e0a\uff0c\u5176\u4e2d\u4e00\u5c0f\u90e8\u5206\u4eba\u4f1a\u60a3ATL\u3002ATL\u5bf9\u6807\u51c6\u5316\u7597\u8010\u53d7\uff0c\u76ee\u524d\u6ca1\u6709\u7279\u522b\u6709\u6548\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u75c5\u4eba\u76845\u5e74\u751f\u5b58\u7387\u4ec5\u4e3a14%\u3002\u6bcf\u5e74\u6709\u7ea6\u6709700-1000\u65e5\u672c\u4eba\u6b7b\u4e8eATL\u3002\u4e5f\u662f\u57fa\u4e8e\u6b64\uff0cMogamulizumab\u7684\u9002\u5e94\u75c7\u8303\u56f4\uff0c\u5f88\u53ef\u80fd\u53ef\u4ee5\u6269\u5927\u3002<\/p>\n

\u8fc4\u4eca\u4e3a\u6b62\uff0c\u53ea\u6709Mogamulizumab\u4e00\u79cd\u9776\u5411\u4e8eGPCR\u7684\u5355\u6297\u7c7b\u836f\u7269\u83b7\u6279\u4e0a\u5e02\u3002\u9664\u4eca\u65e5\u83b7FDA\u6279\u51c6\u5916\uff0cmogamulizumab\u57282012\u5e743\u670830\u65e5\u83b7\u65e5\u672c\u539a\u751f\u52b3\u52a8\u7701\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u590d\u53d1\u6216\u96be\u6cbb\u578bCCR4\u9633\u6027\u7684\u6210\u4ebaT\u7ec6\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u3002<\/p>\n

\u56fe\u88682Mogamulizumab\u5e02\u573a\u9500\u552e\u60c5\u51b5\u5206\u6790\uff08\u767e\u4e07\u7f8e\u5143\uff09<\/strong><\/p>\n

\"\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u53c8\u83b7\u4e00\u7a81\u7834\u6027\u836f\u7269\uff01\"<\/p>\n

\u8d44\u6599\u6765\u6e90\uff1aPDB\uff0c\u4e2d\u56fd\u533b\u836f\u5de5\u4e1a\u4fe1\u606f\u4e2d\u5fc3<\/strong><\/p>\n

\u968f\u7740\u5355\u6297\u7c7b\u836f\u7269\u5f00\u53d1\u6280\u672f\u7684\u8fdb\u6b65\uff0cGPCR\u6210\u4e3a\u836f\u7269\u5f00\u53d1\u7684\u70ed\u70b9\u3002\u76ee\u524d\u8ba4\u4e3a\uff0c\u53ef\u4ee5\u6210\u4e3a\u836f\u7269\u9776\u70b9\u7684GPCR\u7ea6\u4e3a370\u4e2a\u3002\u9488\u5bf9GPCR\u9776\u70b9\uff0c\u6297\u4f53\u836f\u7269\u6240\u8d77\u5230\u4f5c\u7528\u4e3b\u8981\u662f\u963b\u65ad\u80de\u5916\u4fe1\u53f7\u5bf9\u9776\u70b9\u7684\u6fc0\u6d3b\uff0c\u8c03\u63a7\u7531\u9776\u70b9\u4ecb\u5bfc\u7684\u80de\u5185\u4fe1\u53f7\u4f20\u5bfc\u3002\u76ee\u524d\u4e3b\u8981\u5de5\u4f5c\u96c6\u4e2d\u4e8e\u80bf\u7624\u5b66\u3001\u708e\u75c7\u6027\u75be\u75c5\u3001\u81ea\u4f53\u514d\u75ab\u6027\u75be\u75c5\u53ca\u4ee3\u8c22\u6027\u75be\u75c5\uff1b\u53e6\u5916\u4e5f\u6709\u5f88\u591a\u7814\u53d1\u9879\u76ee\u5728\u611f\u67d3\u6027\u75be\u75c5\u3001\u75bc\u75db\u3001\u504f\u5934\u75bc\u548c\u7ea4\u7ef4\u5316\u7b49\u9886\u57df\u5f00\u5c55\u3002<\/p>\n

\u56fe\u88683GPCR\u6297\u4f53\u5728\u7814\u60c5\u51b5\u5206\u6790<\/strong><\/p>\n

\"\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u53c8\u83b7\u4e00\u7a81\u7834\u6027\u836f\u7269\uff01\"<\/p>\n

\u8d44\u6599\u6765\u6e90\uff1aCPM\uff0c\u4e2d\u56fd\u533b\u836f\u5de5\u4e1a\u4fe1\u606f\u4e2d\u5fc3<\/strong><\/p>\n

\u4e09\u3001Poteligeo\u5bf9\u6211\u56fd\u7684\u610f\u4e49<\/strong><\/p>\n

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\u4e00\u65b9\u9762\uff0c\u76f8\u5bf9\u4e8e\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u3001\u7ec6\u80de\u56e0\u5b50\u7b49\u9776\u70b9\uff0cGPCR\u7c7b\u9776\u70b9\u5bf9\u4e8e\u6297\u4f53\u836f\u7269\u7814\u53d1\u6765\u8bf4\u5c1a\u672a\u88ab\u5145\u5206\u5f00\u57a6\uff0c\u7531\u4e8e\u5176\u6784\u6548\u5173\u7cfb\u7684\u590d\u6742\u6027\uff0c\u5bf9\u4e8e\u8fd9\u8fd9\u4e00\u7c7b\u9776\u70b9\u7684\u836f\u5b66\u6027\u8d28\u7684\u7814\u7a76\u8fd8\u6bd4\u8f83\u6d45\u663e\uff1b\u4ece\u5168\u7403\u4ea7\u54c1\u7ebf\u6765\u770b\uff0c\u666e\u904d\u5904\u4e8e\u65e9\u671f\u9636\u6bb5\uff0c\u4e14\u7ade\u4e89\u8fd8\u8fdc\u672a\u5230\u6fc0\u70c8\u7684\u7a0b\u5ea6\u3002\u56fd\u5185\u4f01\u4e1a\u82e5\u80fd\u91cd\u89c6\u8fd9\u65b9\u9762\u7684\u7814\u53d1\uff0c\u5728\u8f83\u4e3a\u6210\u719f\u7684\u9776\u70b9\u4e0a\u5feb\u901f\u8ddf\u8fdb\uff0c\u540c\u65f6\u4e0e\u4ece\u4e8bGPCR\u86cb\u767d\u7814\u7a76\u7684\u79d1\u7814\u673a\u6784\uff08\u5982\u4e0a\u6d77\u79d1\u6280\u5927\u5b66iHuman\u7814\u7a76\u6240\u3001\u4e2d\u79d1\u9662\u4e0a\u6d77\u836f\u7269\u6240\uff09\u5f00\u5c55\u6df1\u5165\u5408\u4f5c\uff0c\u4ece\u86cb\u767d\u673a\u5236\u548c\u7ed3\u6784\u5165\u624b\u6316\u6398\u65e9\u671f\u9879\u76ee\uff0c\u5219\u6709\u671b\u5360\u9886\u4e00\u5e2d\u4e4b\u5730\u3002<\/p>\n

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