{"id":41193,"date":"2018-09-13T01:00:00","date_gmt":"2018-09-17T06:51:12","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e8%8d%af%e7%89%a9%e7%a0%94%e5%8f%91%e4%b8%ad%e5%9f%ba%e5%9b%a0%e6%af%92%e6%80%a7%e6%9d%82%e8%b4%a8%e7%9a%84%e6%8e%a7%e5%88%b6%e7%ad%96%e7%95%a5%e4%b8%8e%e6%96%b9%e6%b3%95%e6%8e%a2%e7%b4%a2%e8%bf%9b\/"},"modified":"2018-09-17T14:51:21","modified_gmt":"2018-09-17T06:51:21","slug":"%e8%8d%af%e7%89%a9%e7%a0%94%e5%8f%91%e4%b8%ad%e5%9f%ba%e5%9b%a0%e6%af%92%e6%80%a7%e6%9d%82%e8%b4%a8%e7%9a%84%e6%8e%a7%e5%88%b6%e7%ad%96%e7%95%a5%e4%b8%8e%e6%96%b9%e6%b3%95%e6%8e%a2%e7%b4%a2%e8%bf%9b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/41193\/","title":{"rendered":"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55<\/strong><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">Advances in Control Strategies and Methods for Genotoxic Impurities in Drug Research &amp; Development<\/strong><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;text-align: center;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u5f20 \u97011,2\uff0c\u5f20\u82f1\u4fca1,2\uff0c\u8042 \u98da1<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;text-align: center;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">(1. \u5e7f\u4e1c\u4e1c\u9633\u5149\u96c6\u56e2\u836f\u4e1a\u7814\u7a76\u9662\uff0c\u5e7f\u4e1c\u4e1c\u839e 523871\uff1b2. \u6297\u611f\u67d3\u65b0\u836f\u7814\u53d1\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\uff0c\u5e7f\u4e1c\u4e1c\u9633\u5149\u836f\u4e1a\uff0c\u5e7f\u4e1c\u4e1c\u839e 523871)<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size: 16px;white-space: normal;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;transform: rotate(0deg);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding-right: 2em;padding-left: 2em;max-width: 100%;transform: rotate(0deg);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;height: 3em;border-right: 2px solid rgb(36, 96, 142);border-left: 2px solid rgb(36, 96, 142);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: -7px;max-width: 100%;display: flex;justify-content: space-between;align-items: flex-end;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-left: 1.7em;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section   style=\"max-width: 100%;box-sizing: border-box;border-width: 2px;border-style: solid;border-color: rgb(142, 36, 96);width: 12px;height: 12px;border-radius: 100%;color: rgb(255, 255, 255);background: rgb(36, 96, 142);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-right: 1.7em;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section   style=\"max-width: 100%;box-sizing: border-box;border-width: 2px;border-style: solid;border-color: rgb(142, 36, 96);width: 12px;height: 12px;border-radius: 100%;color: rgb(255, 255, 255);background: rgb(36, 96, 142);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: -10px;padding-right: 5px;padding-bottom: 20px;padding-left: 15px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-bottom: 8px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(51, 51, 51);color: rgb(255, 255, 255);background-color: rgb(36, 96, 142);word-wrap: break-word !important;\">\n<section style=\"margin-top: -10px;margin-right: 10px;margin-left: -10px;padding: 20px 10px 10px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(51, 51, 51);background-color: rgb(254, 254, 254);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"padding: 10px 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 14px;line-height: 1.75em;color: rgb(36, 96, 142);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6458\u8981\uff1a\u672c\u6587\u9996\u5148\u5bf9\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u8fdb\u884c\u4e86\u5fc5\u8981\u7684\u4ecb\u7ecd\uff0c\u901a\u8fc7\u5177\u4f53\u6848\u4f8b\u5bf9\u836f\u7269\u5408\u6210\u4e0e\u5de5\u827a\u4e2d\u5e38\u89c1\u7684\u6f5c\u5728\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u8b66\u793a\u7ed3\u6784\u8fdb\u884c\u5206\u6790\u548c\u5f52\u7c7b\uff0c\u5e76\u901a\u8fc7\u5b9e\u4f8b\u91cd\u70b9\u63a2\u8ba8\u4e86\u836f\u7269\u5408\u6210\u5de5\u827a\u8fc7\u7a0b\u4e2d\u5982\u4f55\u91c6\u7528\u201c\u907f\u514d-\u63a7\u5236-\u6e05\u9664\u201d\u7684\u7b56\u7565\u4e0e\u65b9\u6cd5\uff0c\u5206\u6790\u4e86\u4e00\u4e9b\u8de8\u56fd\u5236\u836f\u516c\u53f8\u7684\u6210\u529f\u7ecf\u9a8c\u4e0e\u8fdb\u5c55\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5173\u952e\u8bcd\uff1a\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\uff1b\u201c\u907f\u514d-\u63a7\u5236-\u6e05\u9664\u201d\u7b56\u7565\uff1b\u5de5\u827a\u4f18\u5316\uff1b\u836f\u7269\u5408\u6210<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 560px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537167073.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size: 16px;white-space: normal;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"margin-right: auto;margin-left: auto;max-width: 100%;width: 602px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding: 10px;max-width: 100%;word-wrap: break-word;line-height: 2em;word-break: normal;text-align: center;color: rgb(254, 254, 254);transform: rotateZ(0deg);background-color: rgb(123, 154, 181);box-sizing: border-box !important;\"><span class=\"\"  style=\"max-width: 100%;color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u4ee5\u4e0b\u4e3a\u6587\u7ae0\u8282\u9009<\/span><\/section>\n<p style=\"margin-top: -1px;max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"      style=\"width: 602px;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537167073.png\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">1 \u4e09\u8d77\u6bd2\u7d20\u95e8\u4e8b\u4ef6\u7ed9\u5236\u836f\u884c\u4e1a\u5e26\u6765\u7684\u8b66\u9192\u548c\u53cd\u601d<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">2007 \u5e746 \u67086 \u65e5\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40(European Medicines Agency\uff0cEMA) \u53d1\u73b0\u90e8\u5206\u6279\u6b21\u7684\u6297\u7231\u6ecb\u75c5\u836f\u7269Viracept\uff0c\u5373\u5948\u975e\u90a3\u97e6\u7532\u78fa\u9178\u76d0( 1) \u4e2d\u542b\u6709\u9ad8\u5242\u91cf\u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d28(genotoxic impurities\uff0cGTI)\u7532\u78fa\u9178\u4e59\u916f(2) ( \u542b\u91cf\u8d85\u8fc71.1\u00d710-3)\uff0c\u51b3\u5b9a\u53ec\u56de\u7531\u7f57\u6c0f\u5236\u836f\u751f\u4ea7\u76841( \u5316\u5408\u7269\u7ed3\u6784\u89c1\u56fe1)[1\u20142]\u30022 \u662f\u6f5c\u5728\u7684\u81f4\u764c\u7269\u8d28\uff0c\u5728\u836f\u7269\u5242\u91cf\u4e3a2.5 g\/d \u7684\u60c5\u51b5\u4e0b\uff0c\u9ad8\u8fbe2.75 mg \u76842 \u53ef\u80fd\u88ab\u60a3\u8005\u6444\u5165\u4f53\u5185\uff0c\u8fdb\u800c\u5f71\u54cd\u5230\u60a3\u8005\u7684\u8eab\u4f53\u5065\u5eb7\u3002\u65e0\u72ec\u6709\u5076\uff0c2018 \u5e747 \u670814 \u65e5\uff0c\u534e\u6d77\u5236\u836f\u751f\u4ea7\u7684\u9ad8\u8840\u538b\u7528\u836f\u7f2c\u6c99\u5766(valsartan\uff0c3) \u7531\u4e8e\u68c0\u6d4b\u51fa\u542b\u6709\u5fae\u91cf( \u542b\u91cf\u5927\u4e8e0.3\u00d710-6\uff0c\u53730.3 ppm)\u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d28N,N- \u4e8c\u7532\u57fa\u4e9a\u785d\u80fa(NDMA\uff0c4)\uff0c3 \u53ca\u5176\u76f8\u5173\u5236\u5242\u4e5f\u88ab\u5ba3\u5e03\u4ece\u6b27\u6d32\u3001\u7f8e\u56fd\u548c\u4e2d\u56fd\u5e02\u573a\u4e0a\u53ec\u56de( \u5316\u5408\u7269\u7ed3\u6784\u89c1\u56fe1)\u3002\u4e0d\u5e78\u7684\u662f\uff0c2018 \u5e748\u670820 \u65e5\uff0c\u5728\u5370\u5ea6Torrent \u5236\u836f\u751f\u4ea7\u7684\u7f2c\u6c99\u5766\u7247\u5242\u4e2d\u4e5f\u68c0\u6d4b\u51fa\u542b\u6709NDMA\uff0c\u8be5\u516c\u53f8\u4e5f\u4ece\u7f8e\u56fd\u5e02\u573a\u4e0a\u81ea\u613f\u53ec\u56de\u4e8614 \u6279\u6b21\u7684\u76f8\u5173\u836f\u54c1\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 498px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537167074.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">2 \u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u57fa\u672c\u6982\u5ff5\u4e0e\u63a7\u5236\u539f\u5219<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u662f\u6307\u80fd\u76f4\u63a5\u6216\u95f4\u63a5\u635f\u5bb3DNA\u3001\u5f15\u8d77\u57fa\u56e0\u7a81\u53d8\u6216\u81f4\u764c\u7684\u4e00\u7c7b\u7269\u8d28\u3002\u5176\u5bf9DNA \u7684\u635f\u5bb3\u4f5c\u7528\u5305\u62ec\u67d3\u8272\u4f53\u65ad\u88c2\u3001DNA \u91cd\u7ec4\u53ca\u590d\u5236\u8fc7\u7a0b\u4e2d\u5171\u4ef7\u952e\u7684\u63d2\u5165\u548c\u4fee\u9970\uff0c\u4e5f\u5305\u62ec\u5728\u7ec6\u80de\u6c34\u5e73\u4e0a\u4ea7\u751f\u57fa\u56e0\u6bd2\u6027\u7269\u8d28\u800c\u4ea7\u751f\u7684\u7a81\u53d8\u3002\u968f\u7740\u79d1\u5b66\u7684\u8fdb\u6b65\u548c\u836f\u653f\u76d1\u7ba1\u7684\u65e5\u8d8b\u5b8c\u5584\uff0c2006 \u5e74\u6b27\u6d32EMA\u3001\u7f8e\u56fd\u533b\u836f\u7814\u7a76\u4e0e\u5236\u9020\u5546\u534f\u4f1a(PhRMA)\uff0c2008 \u5e74\u7f8e\u56fdFDA \u5148\u540e\u9881\u53d1\u4e86\u5173\u4e8e\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u9650\u5ea6\u6307\u5357(Guideline on the Limits of Genotoxic Impurities)\uff0c\u548c\u4e00\u5957\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u5206\u7c7b\u3001\u754c\u5b9a\u3001\u68c0\u6d4b\u548c\u98ce\u9669\u8bc4\u4f30\u7684\u7a0b\u5e8f\uff1b2014\u5e74\u4eba\u7528\u836f\u54c1\u6ce8\u518c\u6280\u672f\u8981\u6c42\u56fd\u9645\u534f\u8c03\u4f1a\u8bae(ICH) \u53c8\u8fdb\u4e00\u6b65\u4fee\u8ba2\u4e86\u540c\u65f6\u6ee1\u8db3\u6b27\u7f8e\u7684\u5173\u4e8e\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u6307\u5357ICH M7\uff0c\u8fd9\u6837\u5bf9\u836f\u54c1\u8fdb\u884c\u5145\u5206\u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7814\u7a76\u4e5f\u6210\u4e3a\u836f\u54c1\u80fd\u5426\u83b7\u6279\uff0c\u80fd\u5426\u4e0a\u5e02\u7684\u5173\u952e\u56e0\u7d20\u4e4b\u4e00[4]\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ece\u4f55\u800c\u6765\uff1f\u54ea\u4e9b\u5316\u5b66\u7269\u8d28\u548c\u5b98\u80fd\u56e2\u5177\u6709\u6f5c\u5728\u7684\u57fa\u56e0\u6bd2\u6027\uff1f\u8fd9\u7c7b\u7269\u8d28\u6709\u6ca1\u6709\u65b9\u4fbf\u5224\u65ad\u7684\u8b66\u793a\u7ed3\u6784(structural alerts for genotoxicity) \uff1f\u663e\u7136\uff0c\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u662f\u4ece\u5316\u5b66\u8bd5\u5242\u3001\u5316\u5b66\u5408\u6210\u4e0e\u53cd\u5e94\u4f5c\u7528\u800c\u6765\u7684[5]\uff0c\u6d89\u53ca\u5230\u5408\u6210\u5de5\u827a\u6d41\u7a0b\u7684\u65b9\u65b9\u9762\u9762\u4ee5\u53ca\u968f\u540e\u7684\u836f\u54c1\u7684\u7a33\u5b9a\u6027\u548c\u53ef\u80fd\u7684\u964d\u89e3\uff0c\u662f\u4e00\u4e2a\u6781\u5176\u590d\u6742\u7684\u8fc7\u7a0b\u95ee\u9898( \u56fe2)[6]\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 241px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537167074.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u88681 \u4e2d\u5217\u4e3e\u4e86\u4e00\u4e9b\u5e38\u89c1\u7684GTI \u7684\u6bd2\u7406\u5b66\u9650\u503c\u3002\u4f8b\u5982\u6210\u5e74\u6b63\u5e38\u4eba\u4f53\u5bf9\u4e59\u9170\u80fa\u53ef\u63a5\u53d7\u7684\u6bcf\u65e5\u7684\u6162\u6027\u9650\u5236\u662f\u6444\u5165\u91cf\u5c0f\u4e8e10\u00d710-6( \u537310 ppm)\uff0c\u800c\u53ef\u63a5\u53d7\u7684\u7ec8\u751f\u7d2f\u79ef\u5242\u91cf\u4e3a255 mg\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 278px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537167074.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">3 \u53ef\u80fd\u5177\u6709\u57fa\u56e0\u6bd2\u6027\u7684\u8b66\u793a\u7ed3\u6784<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u56fe3 \u5217\u51fa\u4e86\u4e00\u4e9b\u5e38\u89c1\u7684\u5e26\u6709\u57fa\u56e0\u6bd2\u6027\u8b66\u793a\u7ed3\u6784\u7684\u5b98\u80fd\u56e2[8]\uff0c\u4e5f\u79f0\u4e3aAshby \u548cTennant \u7b80\u5316\u7cfb\u7edf\uff0c\u8fd9\u4e9b\u5b98\u80fd\u56e2\u6d89\u53ca\u5230\u7684\u4e0eDNA \u7684\u53cd\u5e94\u4f17\u6240\u5468\u77e5\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u7ed3\u6784\u5e76\u4e0d\u8be6\u5c3d\uff0c\u4f46\u5374\u662f\u8fdb\u884c\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7ed3\u6784\u8bc4\u4f30\u7684\u57fa\u7840\u3002\u5176\u4ed6\u7684\u7ed3\u6784\u8bc4\u4f30\u5546\u4e1a\u8f6f\u4ef6\u6709DEREK \u548cMcase\u3002\u5f53\u57fa\u56e0\u6bd2\u6027\u5316\u5408\u7269\uff0c\u5982\u73af\u6c27\u5316\u7269\u6216\u82b3\u9999\u80fa\u4f5c\u4e3a\u53cd\u5e94\u7269\u548c\u8bd5\u5242\u53c2\u4e0e\u53cd\u5e94\u5236\u5907\u539f\u6599\u836f\u65f6\uff0c\u6781\u6709\u53ef\u80fd\u7ed9\u6700\u7ec8\u7684\u6d3b\u6027\u836f\u7269\u6210\u5206(API) \u5e26\u6765\u57fa<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u56e0\u6bd2\u6027\u6742\u8d28\u6c61\u67d3\uff0c\u56e0\u6b64\u5bf9GTI \u7684\u4e25\u683c\u68c0\u6d4b\u3001\u63a7\u5236\u548c\u9884\u9632\u5728\u5de5\u827a\u5316\u5b66\u8fc7\u7a0b\u4e2d\u662f\u5fc5\u987b\u7684[9]\u3002\u88682 \u4e3a\u53ef\u80fd\u5e26\u6709\u57fa\u56e0\u6bd2\u6027\u8b66\u793a\u7ed3\u6784\u768420 \u7c7b\u6709\u673a\u5316\u5408\u7269[8]\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 403px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537167074.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 587px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537167074.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u4ece\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7814\u7a76\u6307\u5357\u7684\u51fa\u53f0\u548c\u8ba4\u77e5\u63a5\u53d7\u8fc7\u7a0b(2000\u20142008) \u4e2d\u53ef\u4ee5\u770b\u51fa\uff0c\u5236\u836f\u5de5\u4e1a\u754c\u7684\u8ba4\u77e5\u548c\u4e86\u89e3\u662f\u4e0d\u65ad\u52a0\u6df1\u7684\uff0c2010 \u5e74OPRD(Organic Process Research &amp; Development) \u671f\u520a\u8fd8\u4e13\u95e8\u7ec4\u7ec7\u53d1\u8868\u4e86\u5173\u4e8e\u57fa\u56e0\u6bd2\u6027\u7814\u7a76\u7684\u4e13\u520a[13]\uff0c\u5bf9\u7279\u5b9a\u4e0a\u5e02\u836f\u7269\u7684\u57fa\u56e0\u6bd2\u6027\u7269\u8d28\u7684\u7814\u7a76\u4e5f\u6709\u6587\u732e\u53d1\u8868\uff0c\u88683 \u548c\u56fe4 \u7f57\u5217\u4e86\u8fd1\u5e74\u6765\u4e00\u4e9b\u53ef\u80fd\u542b\u6709\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u5e38\u7528\u836f\u54c1\uff0c\u53ca\u7b14\u8005\u5224\u65ad\u7684\u53ef\u80fd\u6765\u6e90\u548c\u76f8\u5e94\u7684\u5206\u6790\u65b9\u6cd5\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 578px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537167075.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 579px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537167075.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u56fe5 \u662f\u5728\u539f\u6599\u836f\u4e2d\u786e\u5b9a\u3001\u63a7\u5236\u548c\u6d4b\u5b9a\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u6d41\u7a0b\u56fe( \u6216\u79f0\u4e4b\u4e3a\u51b3\u7b56\u6811)\u3002\u4ece\u56fe\u4e2d\u4e0d\u96be\u53d1\u73b0\u8be5\u6d41\u7a0b\u6d89\u53ca\u5230\u6574\u4e2a\u5408\u6210\u8fc7\u7a0b\uff0c\u5c24\u5176\u662f\u4e0b\u6e38\u7684\u5de5\u827a\u5316\u5b66\uff0c\u800c\u4e14\u548c\u6bd2\u7406\u7684\u8bc4\u4f30\u3001\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u9274\u5b9a\u548c\u8fc7\u7a0b\u7684\u63a7\u5236\u65b9\u6848\uff0c\u4ee5\u53ca\u5206\u6790\u65b9\u6cd5\u7684\u9009\u62e9\u548c\u4f7f\u7528\u7d27\u5bc6\u76f8\u5173\uff0c\u662f\u4e00\u4e2a\u590d\u6742\u7ec6\u81f4\u548c\u903b\u8f91\u5206\u6790\u7684\u8fc7\u7a0b\u3002\u503c\u5f97\u5f3a\u8c03\u7684\u662f\uff1a\u5982\u679c\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u5728\u6700\u540e\u4e00\u6b65\u4e2d\u5f15\u5165\uff0c\u5219\u5fc5\u987b\u6839\u6910\u6bd2\u7406\u5b66\u7684\u8bc4\u4f30\u62a5\u544a\uff0c\u8bbe\u7acb\u5176\u9650\u5236\u6807\u51c6( \u6781\u9650\u6d4b\u8bd5) \uff1b\u5982\u679c\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u662f\u5728\u8fdc\u79bb\u6700\u540e\u4e00\u6b65\u53cd\u5e94( \u57284 \u6b65\u4ee5\u4e0a) \u5f15\u5165\u7684\uff0c\u5219\u53ef\u4ee5\u901a\u8fc7\u8bc1\u660e\u540e\u7eed\u5316\u5b66\u5de5\u827a\u4e2d\u6bcf\u6b65\u73af\u8282\u7684\u5408\u7406\u6027\uff0c\u8bc1\u660e\u53ef\u6709\u6548\u5730\u6e05\u9664GTI \u6765\u514d\u9664\u63a7\u5236( \u514d\u68c0GTI)\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 564px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537167075.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8981\u60f3\u5bf9\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u4ea7\u751f\u4ee5\u53ca\u53ef\u80fd\u7684\u7ed3\u6784\u505a\u51c6\u786e\u7684\u5224\u65ad\uff0c\u9700\u8981\u6709\u5f88\u597d\u7684\u4e13\u4e1a\u77e5\u8bc6\u548c\u7406\u8bba\u4f9d\u636e\u4f5c\u57fa\u7840\uff0c\u5c24\u5176\u9700\u8981\u5bf9\u4e00\u4e9b\u53cd\u5e94\u7ec6\u8282\u548c\u5de5\u827a\u6d41\u7a0b\u8fdb\u884c\u6df1\u601d\u719f\u8651\u3002\u4f8b\u5982\u88683 \u4e2d\u5bf9\u5384\u6d1b\u66ff\u5c3c(14) \u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u68c0\u6d4b\u53ea\u68c03- \u4e59\u7094\u82ef\u80fa(16) \u662f\u4e0d\u591f\u7684\uff1b\u5384\u6d1b\u66ff\u5c3c\u5728\u6210\u4e3a\u76d0\u9178\u76d0\u7684\u8fc7\u7a0b\u4e2d\u662f\u5426\u4f1a\u4ea7\u751f\u57fa\u56e0\u6bd2\u6027\u6742\u8d2817 \u548c18\uff0c\u4ee5\u53ca\u76d0\u9178\u5384\u6d1b\u66ff\u5c3c\u5728\u8d2e\u5b58\u8fc7\u7a0b\u4e2d\u4f1a\u4e0d\u4f1a\u964d\u89e3\u4ea7\u751f17 \u548c18\uff0c\u90fd\u662f\u503c\u5f97\u5173\u6ce8\u7684( \u56fe6)[26]\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 592px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537167075-1.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">4 \u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u201c\u907f\u514d- \u63a7\u5236- \u6e05\u9664\u201d(avoidcontrol-purge) \u7b56\u7565\u5728\u836f\u7269\u7814\u53d1\u548c\u539f\u6599\u836f\u5de5\u827a\u63a7\u5236\u4e0a\u7684\u5e94\u7528<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u5728\u5de5\u827a\u7814\u7a76\u4e2d\u91c7\u7528\u201c\u907f\u514d[27\u201429]- \u63a7\u5236[30\u201432]-\u6e05\u9664[33\u201435](ACP)\u201d\u7684\u7b56\u7565( \u88684\u3001\u88685) \u80fd\u591f\u6700\u5927\u9650\u5ea6\u51cf\u5c11\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u5bf9\u6700\u7ec8\u4ea7\u54c1\u5373\u539f\u6599\u836fAPI \u7684\u5f71\u54cd\u3002\u4f8b\u5982\u7f8e\u56fd\u793c\u6765\u5236\u836f(Lilly) \u91c7\u7528\u7684GTI( \u6216PGI\uff0cpotentially genotoxic impurities\uff0cGTI \u548cPGI\u8fd9\u4e24\u4e2a\u76f8\u5173\u7684\u540d\u8bcd\u5728\u8bb8\u591a\u573a\u5408\u5f80\u5f80\u4ea4\u66ff\u4f7f\u7528) \u6e05\u9664\u7b56\u7565\u5c31\u5f88\u597d\u5730\u4f53\u73b0\u4e86\u4e0a\u8ff0\u539f\u5219[6,36] \uff1a1) \u81f3\u5c11\u628aGTI( \u6216PGI) \u7684\u751f\u6210\u653e\u5728\u79bb\u6700\u7ec8\u4ea7\u72694 \u6b65\u4ee5\u5916\uff0c\u5e76\u4e14\u5728\u6bcf\u4e00\u6b65\u5206\u6790\u5de5\u827a\u80fd\u5426\u6e05\u9664PGI \u7684\u53ef\u80fd\u6027\uff1b2)\u5bf9\u4e0a\u8ff0\u5de5\u827a\u8fdb\u884c\u8010\u53d7\u6027\u7814\u7a76\u548c\u5904\u7406\uff0c\u5728\u5206\u79bb\u7eaf\u5316\u4e4b\u524d\uff0c\u901a\u8fc7\u6dfb\u52a0(spiking) \u989d\u5916\u7684GTI( \u6216PGI) \u6765\u68c0<\/span><span style=\"font-size: 14px;text-indent: 0em;\">\u9a8c\u7eaf\u5316\u7684\u5f3a\u5ea6\u3002\u4f8b\u5982\uff0c\u6709\u65f6\u52a0\u5165\u9ad8\u8fbe5\uff05\u7684GTI\uff0c\u7136\u540e\u89c2\u5bdf\u6bcf\u6b65\u53cd\u5e94\u6761\u4ef6\u5bf9\u8be5\u6742\u8d28\u7684\u6e05\u9664\u80fd\u529b\uff0c\u76ee\u7684\u662f\u4f7f\u5de5\u827a\u96c6\u4e2d\u4e8e\u8d77\u59cb\u539f\u6599\u6216\u4e2d\u95f4\u4f53\u7684\u4e0a\u6e38\u63a7\u5236\u3002\u8fd9\u79cd\u65b9\u6cd5\u7684\u4f18\u70b9\u662f\u5141\u8bb8\u63a7\u5236\u9650\u5ea6\u8bbe\u5b9a\u5728\u8f83\u9ad8\u6c34\u5e73\u6216\u53ef\u63a5\u53d7\u7684\u7a0b\u5ea6\uff0c\u540c\u65f6\u4e5f\u53ef\u4ee5\u4f7f\u7528\u4e0d\u592a\u590d\u6742\u548c\u7075\u654f\u5ea6\u8981\u6c42\u4e0d\u662f\u5f88\u9ad8\u7684\u5206\u6790\u65b9\u6cd5\uff1b3) \u5728\u5012\u6570\u7b2c\u4e8c\u6b65\u4ea7\u7269\u68c0\u67e5PGI \u7684\u6d53\u5ea6\u542b\u91cf\uff0c\u8bbe\u7f6e\u6781\u9650\u6d4b\u8bd5\uff0c\u9a8c\u8bc1\u7ed3\u679c\uff0c\u8fd9\u6837\u6700\u7ec8\u4ea7\u54c1\u5c31\u6709\u53ef\u80fd\u514d\u68c0GTI\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 299px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537167076.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 276px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537167076.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u5bf9\u6f5c\u5728\u9057\u4f20\u6bd2\u6027\u6742\u8d28\u8fdb\u884c\u98ce\u9669\u8bc4\u4f30\u7684\u7b56\u7565\u5c31\u662f\u5229\u7528\u8d28\u91cf\u6e90\u4e8e\u8bbe\u8ba1(quality by design\uff0cQbD) \u63d0\u4f9b\u66f4\u8be6\u5c3d\u7684\u5bf9\u5de5\u827a\u548c\u5206\u6790\u7684\u7406\u89e3( 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\u5de5\u827a\uff0c\u800c\u4e14\u8fd8\u53ef\u4ee5\u8bc6\u522b\u5e76\u51cf\u5c0f\u7814\u7a76\u4eba\u5458\u9ad8\u5ea6\u5173\u6ce8\u7684\u4e00\u7c7b\u6742\u8d28\u7684\u98ce\u9669\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 279px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537167076.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">2012 \u5e74\uff0cMadasu \u7b49\u62a5\u9053\u4e86\u5546\u4e1a\u5316\u5207\u5b9e\u53ef\u884c\u7684\u6c2f\u6c99\u5766\u94be\u76d0(25) \u7684\u4e94\u6b65\u5408\u6210\u65b9\u6cd5[37]\uff0c\u4ee555.5\uff05\u7684\u6536\u7387\u548c99.9\uff05\u7684\u7eaf\u5ea6\u5236\u5907\u4e86API( \u56fe8)\u3002\u5176\u4eae\u70b9\u662f\u5728\u56db\u6c2e\u5511\u7684\u5408\u6210\u4e2d\u91c7\u7528\u4e86\u53e0\u6c2e\u94a0\uff0c\u4f7f\u7528\u4e86N- \u7532\u57fa\u5421\u54af\u70f7\u916e(NMP)\/ \u7532\u82ef\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\u8fdb\u884c[3+2] \u5076\u6781\u52a0\u6210\u3002\u7f8e\u4e2d\u4e0d\u8db3\u7684\u662f\u53cd\u5e94\u6e29\u5ea6\u8f83\u9ad8\u3001\u53cd\u5e94\u65f6\u95f4\u957f\u8fbe35 h \uff1b\u4f46\u6574\u4e2a\u5de5\u827a\u8fc7\u7a0b\u5408\u7406\u5229\u7528\u4e86\u53e0\u7f29\u5de5\u827a\uff0c\u907f\u514d\u4e86\u4e0d\u5fc5\u8981\u7684\u5206\u79bb\u7eaf\u5316\uff0c\u7ecf\u6d4e\u53ef\u884c\u4e14\u6ee1\u8db3\u4e86\u6cd5\u89c4\u8981\u6c42\uff1b\u800c\u4e14\u4ece\u6c30\u5316\u7269\u5230\u56db\u6c2e\u5511\u7684\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\u53ef\u63a7\uff0c\u4e5f\u514b\u670d\u4e86\u53e0\u6c2e\u9178\u526f\u4ea7\u7269\u7684\u6613\u7206\u95ee\u9898\u3002\u503c\u5f97\u5f3a\u8c03\u7684\u662f\uff0c\u5728\u8fd9\u4e2a\u5de5\u827a\u8fc7\u7a0b\u4e2d\uff0c\u5e76\u6ca1\u6709\u68c0\u6d4b\u5230\u57fa\u56e0\u6bd2\u6027\u6742\u8d28NDMA( \u4f7f\u7528\u7684\u5076\u6781\u6eb6\u5242\u662fNMP\uff0c\u6ca1\u6709\u4f7f\u7528DMF)\uff0c\u4f46\u53d1\u73b0\u542b\u67090.02\uff05\u7684\u53e0\u6c2e\u5316\u726926\uff0c\u8be5\u5316\u5408\u7269\u5728\u5904\u7406\u540e\u53ef\u4ee5\u6e05\u9664\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 572px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537167076.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;text-indent: 0em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u7f2c\u6c99\u5766( 3) 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\u56fe9)\uff0c\u8f6c\u5316\u7387\u63d0\u9ad8\u7ea630\uff05\uff0c\u201c\u4e09\u5e9f\u201d\u4ea7\u751f\u91cf\u964d\u4f4e\u7ea630\uff05\uff0c\u5f02\u6784\u4f53\u6742\u8d28\u4e5f\u5f97\u5230\u4e86\u6709\u6548\u63a7\u5236[38\u201439]\u3002\u4f46\u6539\u7528DMF( \u6eb6\u5242\u4e2d\u53ef\u80fd\u542b\u6709\u4e8c\u7532\u80fa\u6742\u8d28) \u4ee5\u53ca\u968f\u540e\u7684\u7528\u4e9a\u785d\u9178\u6dec\u706d\u3001\u8c03\u9178\u5904\u7406\uff0c\u53ef\u80fd\u5f15\u5165\u57fa\u56e0\u6bd2\u6027\u6742\u8d28NDMA[ \u6ce8\uff1a\u5982\u679c\u90fd\u91c7\u7528\u540c\u6837\u7684\u65b9\u6cd5\u8fdb\u884c\u4f18\u5316\uff0c\u90a3\u4e48\u5176\u4ed6\u6c99\u5766\u7c7b\u836f\u7269\u90fd\u6709\u88abNDMA\u6c61\u67d3\u7684\u53ef\u80fd\uff0c\u8fd9\u6837\uff0c\u8be5\u7c7b\u836f\u7269( \u8840\u7ba1\u7d27\u5f20\u7d20\u53d7\u4f53\u2161<\/span><span style=\"font-size: 14px;text-indent: 0em;\">\u6291\u5236\u5242\uff0cARBs) \u4e2d\u5173\u952e\u836f\u6548\u57fa- 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1em;text-align: justify;text-indent: 0em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u5982\u4f55\u65e2\u4fdd\u7559\u91c7\u53d6DMF\/ \u53e0\u6c2e\u94a0\u6709\u6548\u5feb\u901f\u5b89\u5168\u5730\u5236\u5907\u56db\u6c2e\u5511\u7684\u4f18\u70b9\uff0c\u540c\u65f6\u53c8\u514b\u670d\u6216\u6e05\u9664NDMA \u5e26\u6765\u7684\u5371\u5bb3\u5462\uff1f\u663e\u7136\u6700\u5408\u7406\u7684\u7b56\u7565\u5c31\u662f\u5c06\u4ea7\u751fNDMA\u7684\u5316\u5b66\u6b65\u9aa4\u653e\u5728\u6574\u4e2a\u5408\u6210\u5e8f\u5217\u7684\u4e0a\u6e38\u90e8\u5206\uff0c\u7ed9\u4e0b\u6e38\u7684\u540e\u5904\u7406\u548c\u63a7\u5236\u5e26\u6765\u66f4\u591a\u7684\u673a\u4f1a\u3002\u4ee4\u4eba\u6b23\u559c\u7684\u662f\uff0c\u5fb7\u56fd\u7684Ackermann \u548c\u65e5\u672c\u7684Seki \u5206\u522b\u7efc\u8ff0\u4e86\u5229\u7528Ru \u50ac\u5316\u8fdb\u884cC-H \u6d3b\u5316\uff0c\u4e0d\u7ecf\u8fc7\u7ecf\u5178\u7684Suzuki 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title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u5c06\u53ef\u80fd\u4ea7\u751fGTI \u7684\u6b65\u9aa4\u524d\u79fb\u81f3\u5de5\u827a\u6d41\u7a0b\u7684\u4e0a\u6e38\u90e8\u5206\uff0c\u5c06\u6709\u6bd2\u7269\u8d28\u548c\u8bd5\u5242\u5c3d\u91cf\u8fdc\u79bb\u6700\u7ec8\u7684API\u3002\u53e6\u4e00\u4f8b\u5b50\u662f\u8f89\u745e\u5236\u836f\u63a8\u51fa\u7684\u7b2c\u4e00\u4e2a\u6cbb\u7597\u52c3\u8d77\u529f\u80fd\u969c\u788d(ED) \u7684\u53e3\u670d\u836f\u7269\u897f\u5730\u90a3\u975e( \u53c8\u79f0\u201c\u4f1f\u54e5\u201d\uff0c38) \u7684\u5408\u6210\u5de5\u827a( 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break-word !important;width: 563px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537167077-1.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 464px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537167078.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u7f57\u6c0f\u5236\u836f\u5728\u6297\u80bf\u7624\u836f\u7ef4\u83ab\u5fb7\u5409(vismodegib\uff0c53) \u7814\u53d1\u5408\u6210\u5de5\u827a\u8fc7\u7a0b\u4e2d[43]\uff0c\u53d1\u73b0\u5b58\u5728\u4e3b\u8981\u6f5c\u5728\u57fa\u56e0\u6bd2\u6027\u6742\u8d2850 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alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 573px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537167078.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u4e00\u822c\u6765\u8bf4\uff0c\u836f\u7269\u7684\u6742\u8d28\u591a\u662f\u5728\u5408\u6210\u8fc7\u7a0b\u4e2d\u751f\u6210\u7684\u526f\u4ea7\u7269\uff0c\u5176\u7ed3\u6784\u5f80\u5f80\u548c\u76ee\u6807\u5206\u5b50\u6216\u4e2d\u95f4\u4f53\u7ed3\u6784\u7c7b\u4f3c\uff0c\u4f46\u4e0d\u53ef\u5426\u8ba4\uff0c\u6709\u65f6\u4ea7\u751f\u7684GTI \u53ef\u80fd\u8ddf\u76ee\u6807\u4ea7\u7269\u548c\u4e2d\u95f4\u4f53\u90fd\u6ca1\u6709\u5173\u8054\u3002\u4f8b\u5982\u5728\u6297\u7cd6\u5c3f\u75c5\u836f\u7269\u897f\u683c\u5217\u6c40(56) \u7684\u5236\u5907\u8fc7\u7a0b\u4e2d( \u56fe15)\uff0c\u7b2c\u4e00\u6b65\u7532\u9187\u548cHCl\u7684\u7ec4\u5408\u5c31\u6709\u53ef\u80fd\u4ea7\u751f\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u6c2f\u7532\u70f7[44] \uff1b\u5728\u4e00\u4e9b\u6297\u80bf\u7624\u836f\u7269\u5982\u4f0a\u9a6c\u66ff\u5c3c\u6210\u76d0\u7684\u8fc7\u7a0b\u4e2d\uff0c\u5982\u679c\u4f7f\u7528\u4e86\u9187\u7c7b\u6eb6\u5242\uff0c\u5219\u53ef\u80fd\u4ea7\u751f\u76f8\u5bf9\u5e94\u7684\u7532\u78fa\u9178\u916fGTI[45] \uff1b\u5f53\u4e59\u8148\u6c34\u6eb6\u6db2\u5728\u9178\u6027\u6761\u4ef6\u4e0b\u957f\u65f6\u95f4\u52a0\u70ed\u65f6\uff0c\u4e5f\u4f1a\u751f\u6210\u57fa\u56e0\u6bd2\u6027\u7269\u8d28\u4e59\u9170\u80fa\uff0c\u5c3d\u7ba1\u5176\u6c34\u6eb6\u6027\u5f88\u597d\uff0c\u6613\u4e8e\u6392\u9664\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u836f\u7269\u6210\u76d0\u662f\u836f\u7269\u6700\u5e7f\u6cdb\u7684\u5b58\u5728\u5f62\u5f0f[46]\uff0c\u5b83\u4e0d\u4ec5\u6539\u5584\u4e86\u836f\u7269\u7684\u7406\u5316\u6027\u8d28\uff0c\u63d0\u9ad8\u4e86\u836f\u7269\u7684\u6eb6\u89e3\u5ea6\u548c\u751f\u7269\u5229\u7528\u5ea6\uff0c\u800c\u4e14\u8fd8\u4f7f\u836f\u7269\u7684\u6676\u578b\u53ef\u63a7\uff0c\u63d0\u9ad8\u4e86\u836f\u7269\u7684\u7a33\u5b9a\u6027\u3002\u636e\u7edf\u8ba1\uff0c\u572820 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\uff1b\u6240\u4ee5\u6700\u597d\u80fd\u907f\u514d\u5728\u9187\u7c7b\u6eb6\u5242\u4e2d\u6210\u76d0\uff0c\u4f46\u8bb8\u591a\u836f\u7269\u7684\u6700\u4f73\u6676\u578b\u90fd\u662f\u5728\u9187\u7c7b\u6eb6\u5242\u4e2d\u7ed3\u6676\u51fa\u6765\u7684\uff0c\u800c\u4e14\u6709\u53cd\u5e94\u7684\u6eb6\u5242\u5c31\u662f\u9187\uff0c\u8fd9\u5c31\u7ed9\u836f\u54c1\u8d28\u91cf\u63a7\u5236\u5e26\u6765\u4e86\u6781\u5927\u7684\u6311\u6218\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 301px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537167078.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6709\u65f6\u91c7\u7528\u57fa\u56e0\u6bd2\u6027\u7269\u8d28\u4f5c\u4e3a\u53cd\u5e94\u8bd5\u5242\u548c\u539f\u6599\u662f\u4e0d\u53ef\u907f\u514d\u7684\uff0c\u4f8b\u5982\u4f7f\u7528\u80bc\u548c\u80bc\u7684\u884d\u751f\u7269( \u88687)\u3002\u6297\u80bf\u7624\u836f\u7269\u8212\u5c3c\u66ff\u5c3c(59)\u3001\u6297\u7cbe\u795e\u75c5\u836f\u7269\u9f50\u62c9\u897f\u916e(60) \u4ee5\u53ca\u6297\u7cd6\u5c3f\u75c5\u836f\u7269\u897f\u683c\u5217\u6c40(56) \u7b49\u90fd\u4f7f\u7528\u80bc\u4f5c\u4e3a\u8fd8\u539f\u5242\u6216\u662f\u4f5c\u4e3a\u5408\u6210\u5173\u952e\u6742\u73af\u7684\u539f\u6599( \u56fe16)[48\u201449]\uff0c\u4e00\u6761\u4e0d\u6210\u6587\u7684\u89c4\u77e9\u662f\uff1a\u5c3d\u91cf\u628a\u80bc\u6216\u80bc\u7684\u884d\u751f\u7269\u7684\u5316\u5b66\u5408\u6210\u653e\u5728\u5408\u6210\u5de5\u827a\u7684\u4e0a\u6e38\u90e8\u5206\uff0c\u8fd9\u6837\u5c31\u80fd\u63d0\u4f9b\u66f4\u591a\u7684\u673a\u4f1a\u5c06\u76f8\u5173\u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u63a7\u5236\u5728\u53ef\u63a7\u7684TTC \u503c\u4ee5\u4e0b\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 296px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537167079.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 492px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537167079.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u5728\u4f53\u5916\u8bd5\u9a8c\u4e2d\u53d1\u73b0\uff0c\u5bf9\u7532\u82ef\u78fa\u9178\u5f02\u4e19\u916f\u6bd4\u5176\u4ed6\u78fa\u9178\u916f\u7684\u81f4\u8bf1\u53d8\u6027\u66f4\u5f3a\u3002\u845b\u5170\u7d20\u53f2\u514b(GSK) \u5728\u5730\u683c\u5217\u6c40(denagliptin) \u7532\u82ef\u78fa\u9178\u76d0(62) \u9879\u76ee\u4e0a\u5c31\u5f88\u597d\u5730\u5229\u7528\u4e86\u201c\u63a7\u5236- \u6e05\u9664\u201d\u7b56\u7565\u6765\u8fbe\u5230\u5b89\u5168\u751f\u4ea7API \u7684\u76ee\u7684[50] \uff1a1) \u5728\u6c34\u5b58\u5728\u6761\u4ef6\u4e0b\u8131\u4fdd\u62a4\uff0c\u5c3d\u91cf\u51cf\u5c11\u4efb\u4f55\u751f\u6210\u916f\u7684\u53ef\u80fd\uff1b2) \u53d1\u73b0\u5bf9\u7532\u82ef\u78fa\u9178\u76d0\u7c97\u54c1\u4e2d\u542b\u6709(20 \uff5e 60)\u00d710-6 \u7684\u5bf9\u7532\u82ef\u78fa\u9178\u5f02\u4e19\u916f\uff0c\u5229\u7528\u91cd\u7ed3\u6676(72 \u2103\uff0c1 h) \u6c34\u89e3\u5bf9\u7532\u82ef\u78fa\u9178\u5f02\u4e19\u57fa\u916f( \u56fe17)\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 548px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537167079-1.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u6700\u8fd1\uff0c\u6709\u6587\u732e\u62a5\u9053\u4e86\u4e00\u79cd\u65b0\u578b\u975e\u9ebb\u9189\u6027\u9547\u75db\u836f\u76d0\u9178\u5948\u798f\u6cee(68) \u7684\u516c\u65a4\u7ea7\u5408\u6210\u5de5\u827a( \u56fe18)[51]\u3002\u672c\u54c1\u4e0e\u963f\u7247\u7c7b\u836f\u7269\u548c\u5176\u4ed6\u9547\u75db\u836f\u76f8\u6bd4\u5177\u6709\u975e\u963f\u7247( \u975e\u9ebb\u9189) \u548c\u975e\u753e\u4f53\u4f5c\u7528\uff0c\u526f\u4f5c\u7528\u8f83\u5c11\uff0c\u56e0\u6b64\u4f5c\u4e3a\u9547\u75db\u5242\u5728\u5927\u591a\u6570\u6b27\u6d32\u56fd\u5bb6\u5e7f\u6cdb\u5e94\u7528\u3002\u8be5\u5de5\u827a\u4f7f\u7528\u5355\u4e00\u6eb6\u5242( \u7532\u82ef) \u5728\u4e00\u9505\u4e2d\u5236\u5907\u76d0\u9178\u5948\u798f\u6ceeAPI\uff0c\u603b\u6536\u7387\u826f\u597d( \u2265 79\uff05 )\uff0c\u7eaf\u5ea6\u2265 99.9\uff05\u3002\u4e00\u95055 \u6b65\u5408\u6210\u5de5\u827a\u5305\u62ec\uff1a\u7531\u82ef\u7532\u9170\u82ef\u7532\u9178( 63) \u5f62\u6210\u9170\u6c2f64\uff0c\u7136\u540e\u7ecf\u9170\u80fa\u5316\u3001\u8fd8\u539f\u3001\u73af\u5316\uff0c\u6700\u7ec8\u6210\u76d0\u9178\u76d068\u3002\u4e3b\u8981\u4f18\u70b9\u6709\uff1a\u2460\u4f7f\u7528\u5355\u4e00\u6eb6\u5242\uff0c\u2461\u6bcf\u6b65\u8f6c\u5316\u7387\u5747\u5927\u4e8e90\uff05\uff0c\u2462\u6210\u672c\u6548\u76ca\u9ad8\u4e14\u64cd\u4f5c\u4fbf\u6377\uff0c\u2463\u7ecf\u4e00\u9505\u64cd\u4f5c\uff0c\u603b\u6536\u7387( \u2265 79\uff05 ) \u63d0\u9ad8\u3002\u8be5\u5de5\u827a\u6709\u5982\u4e0b\u7279\u70b9\uff1a\u5408\u7406\u9009\u62e9\u4e86\u9ad8\u6548\u7684\u8fd8\u539f\u8bd5\u5242\u53cc\u4e8c\u6c22\u94dd\u94a0(vitride\uff0cRed-Al)\uff0c\u4e00\u6b65\u6709\u6548\u8fd8\u539f\u4e86\u9170\u80fa\u548c\u916e\u6210\u4e3a\u80fa\u548c\u4e8c\u7ea7\u9187\uff1b\u540c\u65f6\u901a\u8fc7\u7b5b\u9009\uff0c\u91c7\u7528\u7532\u78fa\u9178\/ \u7532\u82ef\u6761\u4ef6\uff0c\u4ee5\u201c\u4e00\u9505\u716e\u201d\u7684\u64cd\u4f5c\u65b9\u5f0f\u6709\u6548\u6210\u73af\u5236\u5907\u4e86API\u3002\u6587\u732e\u79f0\u8be5\u5de5\u827a\u80fd\u591f\u5408\u7406\u5730\u907f\u514d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u5f62\u6210\u3002\u4f46\u4ece\u6700\u7ec8\u7eaf\u531668 \u65f6\u91c7\u7528\u4e86\u7532\u9187\u7684\u60c5\u51b5\u4ee5\u53ca\u7532\u78fa\u9178\u7684\u4f7f\u7528\u6765\u770b\uff0c\u82e5\u6709\u6f5c\u5728\u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d2869 \uff5e 73( \u56fe19) \u7684\u5f62\u6210\uff0c\u5219\u7ecf\u916f\u4ea4\u6362\u53cd\u5e94\uff0c\u6781\u6709\u53ef\u80fd\u5e26\u6765\u7532\u78fa\u9178\u916f\u8fd9\u6837\u7684GTI( \u6ce8\uff1a\u8be5\u6587\u732e\u4f5c\u8005\u53d1\u73b0\u672a\u77e5\u6742\u8d28\u7ecf\u7532\u9187\u3001\u4e59\u9187\u6216\u7532\u9187\/ \u6c34\u7eaf\u5316\u5904\u7406\u540e\u7684\u542b\u91cf\u57280.01\uff05\uff5e 0.2\uff05\u4e4b\u95f4)\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 578px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537167080.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 562px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537167080.jpeg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u5f88\u591a\u6297\u80bf\u7624\u836f\u7269\u90fd\u6709\u82b3\u9999\u80fa\u7684\u7ed3\u6784\uff0c\u5176\u4e2d\u95f4\u4f53\u5927\u591a\u4e5f\u5177\u6709\u82b3\u9999\u80fa\u3001\u785d\u57fa\u3001\u82b3\u9999\u9170\u80fa\u7ed3\u6784\uff0c\u6309\u7167\u57fa\u56e0\u6bd2\u6027\u8b66\u793a\u7ed3\u6784\uff0c\u8fd9\u4e9b\u4e2d\u95f4\u4f53\u90fd\u5177\u6709\u57fa\u56e0\u6bd2\u6027\u3002\u4f46\u662f\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684TTC \u503c\u662f\u57fa\u4e8e\u6b63\u5e38\u4eba\u751f\u547d\u5468\u671f\u6765\u8ba1\u7b97\u7684\u3002ICH M7 \u660e\u786e\u89c4\u5b9a\uff1a\u201c\u8be5\u6307\u5357\u4e0d\u9002\u7528\u4e8e\u665a\u671f\u764c\u75c7\u75c5\u75c7\u6307\u5f81\u6240\u7528\u539f\u6599\u836f\u548c\u5236\u5242\u201d\u3002\u4f8b\u5982\u6c99\u5229\u5ea6\u80fa( thalidomide\uff0c74\uff0c\u56fe20) \u66fe\u662f\u4e00\u79cd\u9547\u9759\u548c\u6b62\u5410\u836f\uff0c\u6700\u521d\u4e8e20 \u4e16\u7eaa50 \u5e74\u4ee3\u5728\u4e34\u5e8a\u4e2d\u7528\u4e8e\u6cbb\u7597\u5b55\u5410\uff0c\u4f46\u7531\u4e8e\u8d85\u8fc710 000 \u540d\u5a74\u513f\u51fa\u751f\u65f6\u60a3\u6709\u4e25\u91cd\u7684\u5148\u5929\u7f3a\u9677\u800c\u88ab\u7981\u7528\uff1b\u4f46\u57281998 \u5e74\uff0c\u6c99\u5229\u5ea6\u80fa\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff1b\u6700\u8fd1\u4ee4\u4eba\u4fe1\u670d\u7684\u652f\u6301\u6c99\u5229\u5ea6\u80fa\u7684\u7ed3\u6784\u8bc1\u636e\u662f\uff0c\u4e8c\u7f9f\u57fa\u915e\u55ea\u7684\u6c27\u5316\u4ee3\u8c22\u4ea7\u7269\u5bfc\u81f4\u4e86DNA 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14px;\">\u81f4\u8c22\uff1a\u611f\u8c22\u5e7f\u4e1c\u7701\u5f15\u8fdb\u521b\u65b0\u521b\u4e1a\u56e2\u961f\u8ba1\u5212(No.201301Y0105381261) \u548c\u6297\u611f\u67d3\u65b0\u836f\u7814\u53d1\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4( \u5b9e\u9a8c\u5ba4\u7f16\u53f72015DQ780357)\uff0c\u5e7f\u4e1c\u4e1c\u9633\u5149\u836f\u4e1a\u6709\u9650\u516c\u53f8\u7684\u8d44\u52a9\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 25.6px;text-align: justify;widows: 1;border-width: 0px;border-style: none;border-color: initial;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(56, 170, 173);border-radius: 10px;background: rgb(224, 255, 246);word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding: 1em 1em 2em;max-width: 100%;box-sizing: border-box;font-size: 14px;letter-spacing: 1.5px;line-height: 1.75em;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">\u4f5c\u8005\u7b80\u4ecb\uff1a\u5f20 \u9701(1962\u2014)\uff0c\u7537\uff0c\u535a\u58eb\uff0c\u56fd\u5bb6\u201c\u5343\u4eba\u8ba1\u5212\u201d\u7279\u8058\u4e13\u5bb6\uff0c\u836f\u7269\u7814\u53d1\/\u5de5\u827a\u7814\u53d1\u9996\u5e2d\u79d1\u5b66\u5bb6\uff0c\u66fe\u4efb\u804c\u4e8e\u8de8\u56fd\u836f\u4e1a\u96c5\u57f9(Abbott)\u3001\u8f89\u745e(Pfizer)\u548c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d(Bristol-Myers-Squibb)\uff0c\u4ece\u4e8b\u65b0\u836f\u7814\u53d1\u548c\u5de5\u827a\u7814\u7a76\u5de5\u4f5c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 14px;\">E-mail\uff1azhangji@hecpharm.com<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;display: -webkit-flex;justify-content: flex-end;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-top: -30px;margin-right: -12px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word 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src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537167080.jpg\" alt=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\" title=\"\u836f\u7269\u7814\u53d1\u4e2d\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u7b56\u7565\u4e0e\u65b9\u6cd5\u63a2\u7d22\u8fdb\u5c55\u2014\u2014\u57f9\u4f18\u7cbe\u9009|\u7814\u53d1\u6280\u672f\u7cfb\u521718\"><\/p>\n<section class=\"\"   style=\"padding-right: 0.5em;padding-left: 0.5em;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;width: 558px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin: 10px auto;max-width: 100%;width: 280px;height: 110px;background-image: 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initial;word-wrap: break-word !important;\">\n<section   style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section randomid=\"97553\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-right: auto;margin-left: auto;max-width: 100%;clear: both;width: 670px;overflow: hidden;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-right: auto;margin-left: auto;max-width: 100%;clear: both;width: 670px;overflow: hidden;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;border-radius: 0.7em;border-width: 0.14em;border-style: solid;border-color: rgb(0, 0, 0);width: 556px;box-shadow: rgb(204, 204, 204) 0.2em 0.2em 0.3em;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 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Advances in Control Strategies  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":41194,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/41193"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=41193"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/41193\/revisions"}],"predecessor-version":[{"id":41226,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/41193\/revisions\/41226"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/41194"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=41193"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=41193"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=41193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}