{"id":42711,"date":"2018-08-14T01:00:00","date_gmt":"2018-09-17T07:07:12","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e3%80%90bioworld-science%e3%80%912018%e5%b9%b47%e6%9c%88%e8%8d%af%e7%89%a9%e5%bf%ab%e8%ae%af-%e5%b8%ae%e5%8a%a9%e6%82%a8%e5%8f%8a%e6%97%b6%e6%8a%8a%e6%8f%a1%e8%8d%af%e7%89%a9%e7%a0%94\/"},"modified":"2018-09-17T15:07:17","modified_gmt":"2018-09-17T07:07:17","slug":"%e3%80%90bioworld-science%e3%80%912018%e5%b9%b47%e6%9c%88%e8%8d%af%e7%89%a9%e5%bf%ab%e8%ae%af-%e5%b8%ae%e5%8a%a9%e6%82%a8%e5%8f%8a%e6%97%b6%e6%8a%8a%e6%8f%a1%e8%8d%af%e7%89%a9%e7%a0%94","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/42711\/","title":{"rendered":"\u3010BioWorld Science\u30112018\u5e747\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001"},"content":{"rendered":"
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Drug Dally News \u5df2\u6b63\u5f0f\u66f4\u540d\u4e3aBioWorld Science<\/span><\/p>\n

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      2018\u5e747\u670817\u65e5\uff0cAbbisko Therapeutics\u53d1\u8868\u65b0\u9896\u7684FGFR-4\u6291\u5236\u5242<\/span><\/p>\n<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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        2018\u5e747\u670818\u65e5\uff0cOno Pharmaceutical\u53d1\u73b0\u65b0\u7684PTK6\u6291\u5236\u5242
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            2018\u5e747\u670826\u65e5\uff0cHenan Metab Biopharma\u53d1\u73b0\u65b0\u578bMcl-1\u6291\u5236\u5242<\/span><\/p>\n<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                FT-2102\u662f\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u7684\u7ec6\u80de\u8d28\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176[NADP]\uff08IDH1\uff09\u7a81\u53d8\u4f53\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u5177\u6709\u6062\u590d\u6b63\u5e38\u7ec6\u80de\u5206\u5316\u7684\u80fd\u529b\uff0c\u4e14\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u98ce\u9669\u8f83\u4f4e\u3002IDH1\u7684\u7a81\u53d8\u5728\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u548c\u90e8\u5206\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff0c\u7ea63%\uff09\u7684\u60a3\u8005\u4e2d\u9ad8\u53d1\uff087-10%\uff09\u3002\u6765\u81eaFORMA Therapeutics\u7684\u7814\u7a76\u4eba\u5458\u65e5\u524d\u53d1\u5e03\u4e86FT-2102\u5355\u836f\u548c\u8054\u5408\u963f\u624e\u80de\u82f7\u6216\u963f\u7cd6\u80de\u82f7\u7528\u4e8eAML\u548cMDS\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u5305\u62ec\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u548c\u4e34\u5e8a\u6709\u6548\u6027\uff08ClinicalTrials.gov \u7f16\u53f7NCT02719574\uff09\u3002\u7528\u836f\u65b9\u5f0f\u4e3a\u6bcf\u5929\u53e3\u670dFT-2102\u5e76\u9010\u6b65\u52a0\u5927\u5242\u91cf\uff0c\u76f4\u5230\u75c5\u60c5\u6076\u5316\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u3002\u6570\u636e\u8bc1\u660e\u8be5\u836f\u4f5c\u4e3a\u5355\u4e00\u836f\u7269\u6216\u4e0e\u963f\u624e\u80de\u82f7\u8054\u5408\u4f7f\u7528\u7684\u8010\u53d7\u6027\u5747\u826f\u597d\uff0c\u5b89\u5168\u6027\u53ef\u7ba1\u63a7\u3002\u5927\u591a\u6570\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u4e3a1-2\u7ea7\uff0c\u4e3b\u8981\u4e3a\u75b2\u52b3\uff0834%\uff09\uff0c\u6076\u5fc3\uff0829%\uff09\uff0c\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0823%)\uff1b\u6700\u5e38\u89c1\u76843-4\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8d2b\u8840\u548c\u80ba\u708e\uff0817-23%\uff09\u3002\u5728\u4ec5\u63a5\u53d7FT-2102\u6cbb\u7597\u7ec4\u4e2d\uff0c32%\u7684\u60a3\u8005\u51fa\u73b0\u5b8c\u5168\u5e94\u7b54\uff08CR\uff09\uff0c\u5176\u4e2d18%\u4e3a\u4e0d\u5b8c\u5168\u8840\u6db2\u5b66\u7f13\u89e3\uff08CRi\uff09\uff0c\u89c2\u5bdf\u65f6\u95f4\u4e3a>18\u4e2a\u6708\u3002\u5728\u8054\u5408\u6cbb\u7597\u961f\u5217\u4e2d\uff0c42%\u7684\u60a3\u8005\u51fa\u73b0CR\uff0c\u5176\u4e2d13%\u4e3aCRi\uff0c\u89c2\u5bdf\u65f6\u95f4\u4e3a>18\u4e2a\u6708\u3002\u6570\u636e\u8868\u660e\uff0c\u5728\u5e26\u6709IDH1\u7a81\u53d8\u7684AML\u6216MDS\u60a3\u8005\u4e2d\uff0cFT-2102\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u5b66\u6570\u636e\u652f\u6301\u5bf9\u8be5\u5019\u9009\u836f\u7269\u8fdb\u884c\u8fdb\u4e00\u6b65\u8bc4\u4ef7\uff0c\u7528\u836f\u5242\u91cf\u4e3a\u6bcf\u65e5\u4e24\u6b21150\u6beb\u514b\u3002\uff08Baer, M. et al. 23rd CongrEurHematolAssoc (EHA) (June 14-17, Stockholm) 2018, Abst PF236\uff09\u3002<\/span><\/p>\n


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                                \u897f\u5948\u5c71\u4f0a\u574e\u533b\u5b66\u9662\u53d1\u73b0\u4e86\u4e00\u7c7b\u86cb\u767d\u964d\u89e3\u9776\u5411\u8054\u5408\u4f53\uff08PROTAc\uff09\u5316\u5408\u7269\uff0c\u5b83\u4e00\u4e2a\u7531E3\u6cdb\u7d20\u8fde\u63a5\u9176\u7ed3\u5408\u7247\u6bb5\uff08\u964d\u89e3\/\u5206\u88c2\u6807\u7b7e\uff09\u548c\u4e00\u4e2a\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u91764 \uff08CDK4\uff09\u548c\/\u6216CDK6\u6291\u5236\u5242\u7247\u6bb5\u901a\u8fc7\u8fde\u63a5\u5b50\u76f8\u8fde\uff0c\u636e\u62a5\u9053\u5bf9\u6cbb\u7597\u764c\u75c7\u6709\u6548\u3002\u901a\u8fc7WB\u5206\u6790\uff0c\u4ee3\u8868\u5316\u5408\u7269XY-028-133\u57280.3 mcM\u30011 mcM\u548c3 mcM\u65f6\u80fd\u5728\u4eba\u76ae\u80a4\u764cA375\u7ec6\u80de\u4e2d\u6291\u5236CDK4\u548cCDK6\u7684\u8868\u8fbe\u53ca\u5176\u6d3b\u6027\uff0c\u4ee5\u53caRb\u7684\u78f7\u9178\u5316\uff1b\u57280.3 mcM\u30011 mcM\u65f6\u80fd\u5728\u4eba\u4e73\u817a\u764cT-47D\u7ec6\u80de\u4e2d\u6291\u5236CDK4\u548cCDK6\u7684\u8868\u8fbe\u548cRb\u78f7\u9178\u5316\u3002\u5728\u6709\u5e15\u535a\u897f\u5c3c\u5bf9\u7167\u7684\u7ec6\u80de\u514b\u9686\u8bd5\u9a8c\u4e2d\uff0c\u5b83\u5bf9A375\u7ec6\u80de\u663e\u793a\u51fa\u6297\u589e\u6b96\u6d3b\u6027\uff081 mcM\u6cbb\u75977\u5929\uff0c0.03 mcM\u548c0.1 mcM\u6cbb\u759711\u5929\uff09\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018106870<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

                                \"\u3010BioWorld<\/p>\n

                                \u56fe\u4e3aXY-028-133\u7ed3\u6784<\/span><\/p>\n

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                                2018\u5e747\u670813\u65e5\uff0c\u53ef\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u5206\u5316\u7684\u5316\u5408\u7269<\/p>\n<\/section>\n

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                                \u65e5\u672c\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u53d1\u73b0\u4e86\u4e00\u79cd\u201c\u8868\u89c2\u9057\u4f20\u91cd\u7ec4\u201d\u65b9\u6cd5\uff0c\u8fd9\u79cd\u65b9\u6cd5\u53ef\u4ee5\u8feb\u4f7f\u809d\u764c\u7ec6\u80de\u5206\u5316\uff0c\u4f7f\u5b83\u4eec\u4e0d\u90a3\u4e48\u5177\u6709\u653b\u51fb\u6027\u3002\u8868\u89c2\u9057\u4f20\u7684\u6539\u53d8\u662f\u809d\u810f\u80bf\u7624\u7684\u5e38\u89c1\u7279\u5f81\uff0c\u6cbb\u7597\u7684\u9009\u62e9\u5f88\u5c11\u3002\u8868\u89c2\u9057\u4f20\u7532\u57fa\u5316\u6a21\u5f0f\u63a7\u5236\u7740\u7ec6\u80de\u7684\u53d1\u80b2\u9636\u6bb5\u548c\u7ec6\u80de\u547d\u8fd0\u3002\u4e4b\u524d\u6709\u7814\u7a76\u8868\u660e\uff0c\u809d\u810f\u80bf\u7624\u7ec6\u80de\u53ef\u4ee5\u901a\u8fc7\u7532\u57fa\u5316\u6a21\u5f0f\u9501\u5b9a\u5728\u7c7b\u4f3c\u5e72\u7ec6\u80de\u6216\u7956\u7ec6\u80de\u7684\u72b6\u6001\uff0c\u5e76\u7ef4\u6301\u5728\u589e\u6b96\u72b6\u6001\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u53bb\u7532\u57fa\u5316\u8bd5\u52425-azacytidine\uff085-AZA\uff09\u5728\u5bf9\u7ec6\u80de\u65e0\u6bd2\u7684\u5242\u91cf\u4e0b\u80fd\u591f\u4fc3\u8fdb\u809d\u80bf\u7624\u7ec6\u80de\u7684\u5206\u5316\uff0c\u589e\u52a0\u809d\u810f\u7279\u5f02\u6027\u57fa\u56e0G6Pc\u3001TAT\u3001CYP1A2\u548cHNF4A\u7684\u8868\u8fbe\u4ee5\u53ca\u80bf\u7624\u6291\u5236\u57fa\u56e0CDH1\u7684\u8868\u8fbe\u3002\u5728\u7ec6\u80de\u57f9\u517b\u5b9e\u9a8c\u4e2d\uff0c5-AZA\u5355\u72ec\u4f7f\u7528\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u7684\u589e\u6b96\uff0c\u8054\u5408Nexavar\uff08\u7d22\u62c9\u975e\u5c3c\uff09\u4f7f\u7528\u80fd\u591f\u63d0\u9ad8\u80bf\u7624\u7ec6\u80de\u5bf9\u836f\u7269\u7684\u54cd\u5e94\u3002\u5728\u5c0f\u9f20\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\uff0c5-AZA\u8fd8\u80fd\u591f\u51cf\u7f13\u809d\u810f\u80bf\u7624\u7684\u751f\u957f\u3002\uff08Gailhouste, L. et al. MolTher 2018, Advanced publication\uff09\u3002<\/span><\/p>\n

                                \"\u3010BioWorld<\/p>\n

                                \u5316\u5408\u7269Azacitidine\u7684\u7ed3\u6784<\/span><\/p>\n

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                                2018\u5e747\u670817\u65e5\uff0cAbbisko Therapeutics\u53d1\u8868\u65b0\u9896\u7684FGFR-4\u6291\u5236\u5242<\/span><\/p>\n<\/section>\n

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                                Abbisko Therapeutics\u53d1\u8868\u4e86\u4e00\u7cfb\u5217\u65b0\u9896\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f534\uff08FGFR-4\uff09\u6291\u5236\u5242\uff0c\u6216\u53ef\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u3002\u5728\u819c\u7247\u94b3\u5b9e\u9a8c\u4e2d\uff0c\u4ee3\u8868\u5316\u5408\u7269\u53ef\u6291\u5236FGFR-4\u6d3b\u6027\uff08IC50 = 5.6 nM\uff09\u3002\u5728CellTiter-Glo\u53d1\u5149\u6cd5\u7ec6\u80de\u6d3b\u529b\u68c0\u6d4b\u4e2d\uff0c\u5316\u5408\u7269\u5bf9\u9ad8\u8868\u8fbeFGFR-4\u53d7\u4f53\u7684\u4eba\u809d\u764cHuh-7\u7ec6\u80de\u5177\u6709\u6297\u589e\u6b96\u6d3b\u6027\uff08EC50\u548c\u7edd\u5bf9IC50\u5206\u522b\u4e3a1.3\u548c2.1 nM\uff09\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018113584\uff09\u3002<\/span><\/p>\n

                                \"\u3010BioWorld<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

                                \u56fe\u4e3aWO 2018113584\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/p>\n

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                                2018\u5e747\u670818\u65e5\uff0cOno Pharmaceutical\u53d1\u73b0\u65b0\u7684PTK6\u6291\u5236\u5242<\/span><\/p>\n<\/section>\n

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                                Ono Pharmaceutical\u8fd1\u65e5\u53d1\u8868\u4e86\u4e00\u7c7b\u65b0\u9896\u7684\u86cb\u767d\u916a\u6c28\u9178\u6fc0\u91766\uff08PTK6\uff09\u6291\u5236\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3002\u4ee3\u8868\u5316\u5408\u7269\u5728TR-FRET \u6d4b\u8bd5\u4e2d\u5bf9PTK6\u7684\u6291\u5236\u6d3b\u6027\u4e3aIC50 = 0.005 mcM\uff0c\u5e76\u5bf9MAPK14\u548c\u916a\u6c28\u9178\u6fc0\u9176SYK\u5177\u6709\u9009\u62e9\u6027\uff081 mcM\u7684\u6291\u5236\u7387\u5206\u522b\u4e3a 24%\u548c0%\uff09\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018117177\uff09\u3002<\/span><\/p>\n

                                \"\u3010BioWorld<\/p>\n

                                \u56fe\u4e3aWO 2018117177\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/p>\n

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                                2018\u5e747\u670819\u65e5\uff0cNampt\u6291\u5236\u5242OT-82\u5bf9\u767d\u8840\u75c5\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u6709\u6548<\/p>\n<\/section>\n

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                                OncoTartis\u516c\u53f8\u8fd1\u65e5\u901a\u8fc7\u60a3\u8005\u6e90\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u8bc1\u5b9e\uff0c\u5229\u7528\u6291\u5236\u5242OT-82\u6291\u5236\u70df\u9170\u80fa\u78f7\u9178\u6838\u7cd6\u8f6c\u79fb\u9176\uff08Nampt\uff09\uff0c\u53ef\u80fd\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u6cbb\u7597\u9ad8\u5371\u513f\u7ae5\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u7684\u7b56\u7565\u3002OT-82\u80fd\u591f\u4ee5\u7eb3\u6469\u5c14\u7ea7\u522b\u7684IC50\u5f3a\u6548\u6740\u4f24\u767d\u8840\u75c5\u7ec6\u80de\u7cfb\u548c\u513f\u7ae5\u9ad8\u5371ALL\u7684\u5f02\u79cd\u79fb\u690d\u7ec6\u80de\u3002\u8be5\u836f\u80fd\u964d\u4f4eNAD+\u548c\u4e09\u78f7\u9178\u817a\u82f7\u6c34\u5e73\uff0c\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3002\u7528OT-82\u6cbb\u759720\u4e2a\u513f\u7ae5\u9ad8\u5371ALL\u7684\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u65f6\uff0c\u6240\u6709\u4e2a\u4f53\u5747\u51fa\u73b0\u660e\u663e\u7684\u751f\u957f\u5ef6\u8fdf\uff0c\u5176\u4e2d18\u4e2a\u4e3a\u5ba2\u89c2\u7f13\u89e3\uff0c\u5e76\u68c0\u6d4b\u5230NAD+\u6c34\u5e73\u7684\u964d\u4f4e\u3001ADP\u6838\u7cd6\u805a\u5408\u91761\uff08PARP-1\uff09\u7684\u6291\u5236\u4ee5\u53ca\u8bf1\u5bfc\u6240\u81f4\u7684\u7ec6\u80de\u51cb\u4ea1\u3002OT-82\u8fd8\u589e\u5f3a\u4e86\u8fbe\u6c99\u66ff\u5c3c\u548c\u963f\u7cd6\u80de\u82f7\u7684\u65e0\u4e8b\u4ef6\u751f\u5b58\u7387\u3002\u4e0a\u8ff0\u7ed3\u8bba\u652f\u6301\u5bf9OT-82\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\uff08Somers, K. et al. 25th Meet EurAssoc Cancer Res (EACR) (June 30-3, Amsterdam) 2018, Abst PO-028\uff09\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670823\u65e5\uff0cPP2A \u7684\u6fc0\u6d3b\u80fd\u591f\u5bf9\u6297KRAS\u76f8\u5173\u80bf\u7624
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                                \u82ac\u5170\u56fe\u5c14\u5e93\u751f\u7269\u6280\u672f\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4e00\u79cd\u540d\u4e3a\u86cb\u767d\u78f7\u9178\u91762A\uff08PP2A\uff09\u7684\u9176\uff0c\u5176\u6d3b\u6027\u80fd\u591f\u5f71\u54cd\u5e26\u6709KRAS\u7a81\u53d8\u7684\u80ba\u764c\u7ec6\u80de\u5bf9\u4f17\u591a\u6fc0\u9176\u6291\u5236\u5242\u7684\u654f\u611f\u6027\u3002\u78f7\u9178\u9176\u80fd\u591f\u79fb\u9664\u6fc0\u9176\u901a\u8fc7\u78f7\u9178\u5316\u800c\u6dfb\u52a0\u7684\u86cb\u767d\u6d3b\u5316\u6807\u7b7e\uff0cPP2A\u6b63\u662f\u901a\u8fc7\u5f71\u54cd\u6d3b\u5316\u7684KRAS\u901a\u8def\u6765\u6291\u5236\u80bf\u7624\u4ece\u800c\u53d1\u6325\u6297KRAS\u76f8\u5173\u80bf\u7624\u7684\u4f5c\u7528\uff0c\u8fd9\u4fc3\u4f7f\u79d1\u5b66\u5bb6\u5e7f\u6cdb\u7684\u7814\u7a76PP2A\u5bf9\u80bf\u7624\u7ec6\u80de\u548c\u6fc0\u9176\u6291\u5236\u5242\u6297\u836f\u6027\u7684\u5f71\u54cd\u3002\u7814\u7a76\u53d1\u73b0\uff0cPP2A\u6d3b\u6027\u5f71\u54cd\u4e86\u51e0\u79cd\u6fc0\u9176\u6291\u5236\u5242\u7684\u4f5c\u7528\uff0c\u5c24\u5176\u662f\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff08MEK\uff09\u6291\u5236\u5242\u3002\u4f5c\u8005\u4ecb\u7ecd\u9053\uff0c\u53e3\u670d\u6709\u6548\u7684PP2A\u5c0f\u5206\u5b50\u6fc0\u6d3b\u5242DT-061\u8054\u5408MEK\u6291\u5236\u5242AZD-6244\uff08selumetinib\uff09\uff0c\u80fd\u591f\u9020\u6210\u5bf9p-AKT\u548cMYC\u7684\u6291\u5236\u4ee5\u53ca\u4e24\u79cdKRAS\u76f8\u5173\u80ba\u764c\u5c0f\u9f20\u6a21\u578b\u7684\u80bf\u7624\u6d88\u9000\u3002\u6b64\u5916\uff0cDT-061\u6cbb\u7597\u8fd8\u53ef\u4ee5\u6d88\u9664\u7531MYC\u9a71\u52a8\u7684\u80bf\u7624\u751f\u957f\u3002\u7814\u7a76\u4eba\u5458\u63d0\u5230\uff0c\u201c\u8fd9\u4e9b\u7ed3\u679c\u6307\u793a\u6211\u4eec\u6709\u5fc5\u8981\u66f4\u597d\u5730\u7406\u89e3\u78f7\u9178\u9176\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u5173\u952e\u8c03\u8282\u4f5c\u7528\u3002\u201d\uff08Kauko, O. et al. SciTransl Med 2018, 10(450): eaaq1093\uff09\u3002<\/span><\/p>\n

                                \"\u3010BioWorld<\/p>\n<\/section>\n

                                \u4e0a\u56fe\u4e3aSelumetinib\u7ed3\u6784<\/span><\/section>\n

                                \"\u3010BioWorld<\/p>\n<\/section>\n

                                \u4e0a\u56fe\u4e3aDT-061\u7ed3\u6784<\/span><\/section>\n
                                \n
                                \n
                                \n
                                \n


                                <\/p>\n

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                                2018\u5e747\u670824\u65e5\uff0cBCL-3\u4e0e\u80f6\u8d28\u7624\u60a3\u8005\u70f7\u57fa\u5316\u6cbb\u7597\u7684\u8010\u836f\u6027\u76f8\u5173<\/span><\/p>\n<\/section>\n

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                                <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
                                \n
                                \n
                                \n

                                \u795e\u7ecf\u80f6\u8d28\u7624\u60a3\u8005\u5bf9\u70f7\u57fa\u5316\u836f\u7269\u5316\u7597\u6709\u7740\u4e0d\u540c\u7684\u53cd\u5e94\uff0c\u76ee\u524d\u7f3a\u4e4f\u80fd\u591f\u6709\u6548\u9884\u6d4b\u6cbb\u7597\u6548\u679c\u7684\u65b9\u6cd5\u3002\u6709\u7814\u7a76\u53d1\u73b0\uff0cNF-kappa B\u901a\u8def\u4ee5\u53ca\u7532\u57fa\u5316DNA\u86cb\u767d\u534a\u80f1\u6c28\u9178\u7532\u57fa\u8f6c\u79fb\u9176\uff08MGMT\uff09\u5728\u80f6\u8d28\u7624\u60a3\u8005\u4e2d\u4e0e\u66ff\u83ab\u5511\u80fa\uff08TMZ\uff09\u7b49\u70f7\u57fa\u5316\u836f\u7269\u7684\u8010\u836f\u6027\u9ad8\u5ea6\u76f8\u5173\u3002B\u7ec6\u80de\u6dcb\u5df4\u7624\u86cb\u767d-3\uff08BCL-3\uff09\u662f\u4e00\u79cdNF-kappa B\u5171\u8c03\u8282\u56e0\u5b50\uff0c\u56e0\u6b64\u53ef\u4f5c\u4e3a\u9884\u6d4b\u70f7\u57fa\u5316\u6cbb\u7597\u6548\u679c\u7684\u6f5c\u5728\u9884\u6d4b\u56e0\u5b50\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cBCL-3\u5bf9\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08GBM\uff09\u60a3\u8005\u7684\u751f\u5b58\u7387\u6709\u5f71\u54cd\uff0cBCL-3\u8868\u8fbe\u91cf\u4f4e\u7684\u60a3\u8005\u751f\u5b58\u7387\u9ad8\u4e8e\u8868\u8fbe\u91cf\u9ad8\u7684\u60a3\u8005\u3002\u5728\u591a\u56e0\u7d20\u5206\u6790\u4e2d\uff0cBCL-3\u8868\u8fbe\u4e0eGBM\u60a3\u8005\u7684\u751f\u5b58\u7387\u76f8\u5173\uff08P = 0.017\uff09\uff0c\u800c\u4e0e\u60a3\u8005\u662f\u5426\u63a5\u53d7\u8fc7\u653e\u5c04\u7597\u6cd5\u65e0\u5173\u3002\u52a0\u5165TMZ\u6cbb\u7597\u540e\uff0cBCL-3\u4f4e\u8868\u8fbe\u60a3\u8005\u6bd4\u9ad8\u8868\u8fbe\u60a3\u8005\u7684\u5b58\u6d3b\u65f6\u95f4\u66f4\u957f\uff08P = 0.0084\uff09\u3002\u5728\u53e6\u4e00\u7ec4GBM\u60a3\u8005\u4e2d\uff0cBCL-3\u7684\u8868\u8fbe\u88ab\u8ba4\u4e3a\u4e0eMGMT\u7684\u7532\u57fa\u5316\u72b6\u6001\u6709\u5173\uff0cBCL-3\u4ec5\u5f71\u54cdMGMT\u542f\u52a8\u5b50\u7532\u57fa\u5316\u7a0b\u5ea6\u9ad8\u7684\u80bf\u7624\u7684\u751f\u5b58\u7387\uff08P = 0.013\uff09\u3002\u5728\u4f4e\u5ea6\u80f6\u8d28\u7624\u60a3\u8005\u4e2d\uff0cBCL-3\u7684\u4f4e\u8868\u8fbe\u4e5f\u4e0eTMZ\u6cbb\u7597\u7684\u5b58\u6d3b\u7387\u589e\u52a0\u6b63\u76f8\u5173\uff08P < 0.044\uff09\u3002\u6bd4\u8f83\u80f6\u8d28\u7624\u4e0eGBM\u4e4b\u95f4\u7684BCL-3\u8868\u8fbe\u60c5\u51b5\u53d1\u73b0\uff0cGBM\u60a3\u8005\u7684BCL-3\u8868\u8fbe\u9ad8\u4e8e\u4f4e\u5ea6\u80f6\u8d28\u7624\u60a3\u8005\uff08P < 0.001\uff09\u3002\u4e0a\u8ff0\u7ed3\u679c\u6697\u793a\uff0cBCL-3\u53ef\u4ee5\u9884\u6d4b\u4f7f\u7528TMZ\u7b49\u70f7\u5316\u5242\u6cbb\u7597GBM\u548c\u4f4e\u5ea6\u80f6\u8d28\u7624\u7684\u6548\u679c\u3002\uff08Wu, L. et al. SciTransl Med 2018, 10(448): eaar223<\/span><\/p>\n

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                                2018\u5e747\u670826\u65e5\uff0cHenan Metab Biopharma\u53d1\u73b0\u65b0\u578bMcl-1\u6291\u5236\u5242<\/span><\/p>\n<\/section>\n

                                \n
                                <\/section>\n
                                <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
                                \n
                                \n
                                \n

                                Henan Metab Biopharma\u516c\u53f8\u53d1\u73b0\u4e86\u4e00\u7c7b\u65b0\u578b\u7684\u567b\u5429\u5e76\u5627\u5576\u7c7b\u5316\u5408\u7269\u4f5c\u4e3aMcl-1\u6291\u5236\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3002\u4ee3\u8868\u5316\u5408\u7269\u5728\u8424\u5149\u504f\u632f\u6d4b\u8bd5\u4e2d\u5bf9Mcl-1\u7684\u6291\u5236\u6d3b\u6027\u4e3aIC50\u4e0d\u9ad8\u4e8e1 nM\u3002\u5728\u7ec6\u80deMTT\u6d4b\u8bd5\u4e2d\uff0c\u5316\u5408\u7269\u5bf9\u4eba\u9aa8\u9ad3\u7624\u7ec6\u80deNCI-H929\u7684\u6297\u589e\u6b96\u6d3b\u6027\u4e3aIC50 > 10 nM\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018126898\uff09\u3002<\/span><\/p>\n

                                \"\u3010BioWorld<\/p>\n<\/section>\n

                                \u56fe\u4e3a\u4e13\u5229WO 2018126898\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/section>\n
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                                <\/p>\n<\/section>\n

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                                2<\/strong><\/span>
                                <\/section>\n<\/section>\n<\/section>\n<\/section>\n
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                                \u6297\u80bf\u7624\u514d\u75ab\u7597\u6cd5<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670817\u65e5\uff0c\u8d85\u5206\u5b50AK750\u5728\u764c\u75c7\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u80fd\u589e\u5f3a\u5148\u5929\u514d\u75ab\u6027\u53cd\u5e94<\/p>\n<\/section>\n

                                \n
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                                <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

                                \u5de8\u566c\u7ec6\u80de\u5728\u764c\u75c7\u4e2d\u626e\u6f14\u7740\u53cc\u91cd\u89d2\u8272\u3002M1\u578b\u5de8\u566c\u7ec6\u80de\u53ef\u4ee5\u541e\u566c\u764c\u7ec6\u80de\uff0c\u800c\u81f4\u7624\u6027\u76f8\u5173\u7684M2\u578b\u5de8\u566c\u7ec6\u80de\u5728\u51e0\u4e4e\u6240\u6709\u764c\u75c7\u7684\u80bf\u7624\u95f4\u8d28\u4e2d\u5360\u636e\u4e86\u5f88\u5927\u6bd4\u4f8b\u3002\u764c\u7ec6\u80de\u80fd\u591f\u5206\u6ccc\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08MCSF\uff09\uff0c\u901a\u8fc7\u4e0e\u5355\u6838\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u916a\u6c28\u9178\u6fc0\u9176\u96c6\u843d\u523a\u6fc0\u56e0\u5b501\u53d7\u4f53\uff08CSF-1R\uff09\u7ed3\u5408\uff0c\u62db\u52df\u5de8\u566c\u7ec6\u80de\u5e76\u8bf1\u5bfc\u5176\u5206\u5316\u4e3aM2\u578b\u3002\u6b64\u5916\uff0c\u764c\u7ec6\u80de\u8fd8\u4f1a\u8868\u8fbeCD47\uff0c\u4e0e\u5de8\u566c\u7ec6\u80de\u4e0a\u7684\u4fe1\u53f7\u86cb\u767dalpha \uff08SIRPalpha\uff09\u53d7\u4f53\u7ed3\u5408\uff0c\u9632\u6b62\u5de8\u566c\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u63d0\u51fa\uff0c\u80fd\u591f\u963b\u65adSIRPalpha\u4e0eCD47\u7684\u76f8\u4e92\u4f5c\u7528\u5e76\u540c\u65f6\u6291\u5236CSF-1R\u7684\u8d85\u5206\u5b50\u53ef\u80fd\u4f1a\u6fc0\u53d1\u6297\u80bf\u7624\u5148\u5929\u514d\u75ab\u5e94\u7b54\u3002\u9a6c\u8428\u8bf8\u585e\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u548cInvictus Oncology\u516c\u53f8\u7684\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u5e76\u5f00\u53d1\u4e86\u4e00\u79cd\u80bf\u7624\u76f8\u5173\u7684\u5de8\u566c\u7ec6\u80de\u9776\u5411\u8d85\u5206\u5b50\u7597\u6cd5\uff0c\u79f0\u4e3aAK-750\u3002\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0cAK-750\u5728\u5de8\u566c\u7ec6\u80de\u4e0a\u4e0eSIRPalpha\u7ed3\u5408\uff0c\u963b\u65ad\u4e0eCD47\u7684\u4f5c\u7528\uff0c\u540c\u65f6\u80fd\u591f\u6301\u7eed\u6291\u5236CSF-1R\u4fe1\u53f7\uff0c\u6709\u6548\u5730\u5c06M2\u5de8\u566c\u7ec6\u80de\u91cd\u65b0\u6781\u5316\u4e3aM1\u8868\u578b\u3002\u4f53\u5185\u5b9e\u9a8c\u8bc1\u5b9e\uff0c\u5bf9\u643a\u5e26\u9ed1\u8272\u7d20\u7624B16\/F10\u7684\u5c0f\u9f20\u7ed9\u4e88AK-750\u6cbb\u7597\u540e\uff0c\u80bf\u7624\u7684\u751f\u957f\u88ab\u5b8c\u5168\u6291\u5236\uff0c\u800cCSF-1R\u6291\u5236\u5242BLZ-945\u5bf9\u80bf\u7624\u751f\u957f\u4ec5\u6709\u4e2d\u5ea6\u6291\u5236\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u5bf9AK-750\u6cbb\u7597\u7684\u80bf\u7624\u7684\u5206\u6790\u663e\u793a\uff0cCSF-1R\u7684\u78f7\u9178\u5316\u88ab\u5b8c\u5168\u6291\u5236\uff0cM2\u578b\u5de8\u566c\u7ec6\u80de\u51cf\u5c11\uff0cM1\u578b\u5de8\u566c\u7ec6\u80de\u589e\u52a0\u3002\u4e0eBLZ-945\u76f8\u6bd4\uff0c\u5728\u514d\u75ab\u8010\u53d7\u5c0f\u9f20\u76844T1\u4e73\u817a\u764cIV\u671f\u52a8\u7269\u6a21\u578b\u4e2d\uff0cAKT-750\u80fd\u591f\u663e\u8457\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u51cf\u5c11\u8f6c\u79fb\u6027\u6dcb\u5df4\u7ed3\uff0c\u63d0\u9ad8\u751f\u5b58\u7387\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u540c\u65f6\u963b\u65adCD47-SIRPalpha\u4f5c\u7528\u548cMCSF\u7684CSF-1R\u4fe1\u53f7\u53ef\u80fd\u662f\u4e00\u79cd\u6709\u524d\u9014\u7684\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u3002\uff08Kulkarni, A. et al. Nat Biomed Engineer 2018, Advanced publication\uff09\u3002<\/span>
                                <\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670820\u65e5\uff0cKite\u4e0e Gadeta\u5f00\u53d1\u51fa\u65b0\u578b\u7684\u03b3\u03b4-TCR\u7597\u6cd5<\/span><\/p>\n<\/section>\n

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                                \u5409\u5229\u5fb7\u65d7\u4e0b\u7684Kite\u516c\u53f8\u548cGadeta\u516c\u53f8\u5c06\u5c55\u5f00\u6218\u7565\u5408\u4f5c\uff0c\u5171\u540c\u5f00\u53d1\u03b3\u03b4-T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u5404\u79cd\u764c\u75c7\u3002\u6839\u636e\u8d22\u52a1\u6761\u6b3e\uff0cKite\u5c06\u63d0\u4f9b\u7814\u53d1\u8d44\u91d1\uff0c\u800cGadeta\u5c06\u6709\u8d44\u683c\u83b7\u5f97\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002\u6b64\u5916\uff0cKite\u5c06\u4eceGadeta\u7684\u80a1\u4e1c\u90a3\u91cc\u9884\u5148\u8d2d\u4e70Gadeta\u7684\u80a1\u6743\uff0c\u5e76\u53ef\u80fd\u5728\u5b8c\u6210\u67d0\u4e9b\u7814\u53d1\u91cc\u7a0b\u7891\u540e\u83b7\u5f97Gadeta\u7684\u989d\u5916\u80a1\u6743\u3002Kite\u8fd8\u5c06\u62e5\u5bf9Gadeta\u7684\u72ec\u5bb6\u6536\u8d2d\u6743\u3002Gadeta\u5df2\u7ecf\u5f00\u53d1\u51fa\u4e86\u4e00\u79cd\u4e13\u6709\u6280\u672f\uff0c\u53ef\u4ee5\u5229\u7528\u03b3\u03b4-TCRs\u6765\u8bbe\u8ba1T\u7ec6\u80de\uff0c\u8fd9\u79cd\u6280\u672f\u88ab\u79f0\u4e3aTEGs\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u5404\u79cd\u8840\u6db2\u548c\u5b9e\u4f53\u80bf\u7624\u3002\u8be5\u5e73\u53f0\u6709\u80fd\u529b\u5c06\u8868\u8fbe\u03b1\u548c\u03b2\u7684TCR\u94fe\u7684\u5e38\u89c4T\u7ec6\u80de\u7684\u4f18\u52bf\u4e0e\u6765\u81ea\u03b3\u03b4-T\u7ec6\u80de\u7684TCR\u7ed3\u5408\u8d77\u6765\u3002\u6839\u636e\u4e34\u5e8a\u524d\u8bc4\u4f30\u6a21\u578b\uff0c\u4e0a\u8ff0\u03b3\u03b4-T\u7ec6\u80de\u80fd\u591f\u8bc6\u522b\u764c\u7ec6\u80de\u4e2d\u7684\u65b0\u9776\u6807\u3002\u4e0e\u03b1\u03b2-T\u7ec6\u80de\u4e0d\u540c\uff0c\u03b3\u03b4-TCR\u4e0d\u9700\u8981\u8868\u8fbe\u7528\u4e8e\u9776\u8bc6\u522b\u7684\u7ec6\u80de\u8868\u9762\u86cb\u767d\uff08\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269\uff08MHC\uff09\u5206\u5b50\uff09\uff0c\u5e76\u4e14\u5177\u5907\u5728\u5e94\u6fc0\u6216\u4ee3\u8c22\u6761\u4ef6\u4e0b\u8bc6\u522b\u65b0\u9776\u6807\u7684\u80fd\u529b\uff0c\u4e0a\u8ff0\u7b56\u7565\u4e3a\u5728\u5b9e\u4f53\u80bf\u7624\u4e2d\u5f00\u53d1\u6f5c\u5728\u6709\u6548\u7684\u7ec6\u80de\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u4e86\u6f5c\u5728\u9014\u5f84\u3002\uff08Kite\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670825\u65e5\uff0cFDA\u6279\u51c6Celyad\u7684\u975e\u57fa\u56e0\u7f16\u8f91\u7684\u540c\u79cd\u5f02\u4f53CAR-T\u7ec6\u80de\u4ea7\u54c1CYAD-101\u8fdb\u5165\u4e34\u5e8a<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                FDA\u8fd1\u65e5\u63a5\u53d7\u4e86Celyad\u516c\u53f8\u7684\u5168\u7403\u9996\u4e2a\u975e\u57fa\u56e0\u7f16\u8f91\u7684\u540c\u79cd\u5f02\u4f53CAR-T\u7ec6\u80de\u4ea7\u54c1\u7684IND\u7533\u8bf7\u3002\u8fd9\u9879\u540d\u4e3aAllo-SHRINK\u7684\u7814\u7a76\u5c06\u5728\u65e0\u6cd5\u5207\u9664\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u8bc4\u4f30CYAD-101\u7ed3\u5408\u6807\u51c6\u5316\u7597\u65b9\u6848\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002CYAD-101\u662fCelyad\u516c\u53f8\u7684\u7b2c\u4e00\u79cdCAR-T\u7ec6\u80de\u4ea7\u54c1\uff0c\u5b83\u65e2\u80fd\u7f16\u7801\u81ea\u4f53CYAD-01 CAR-T\uff0c\u53c8\u80fd\u7f16\u7801\u4e00\u79cd\u65b0\u7684\u80bdT\u7ec6\u80de\u53d7\u4f53\u6291\u5236\u5206\u5b50\uff08TIM\uff0c\u4e00\u79cdTCR\u4fe1\u53f7\u6291\u5236\u5242\uff09\u3002TCR\u4fe1\u53f7\u4f1a\u5bfc\u81f4\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff08GvHD\uff09\uff0c\u5e72\u9884\u6216\u6d88\u9664\u5176\u4fe1\u53f7\u8f6c\u5bfc\u53ef\u51cf\u5c11\u6216\u6d88\u9664GvHD\u3002\u5728CYAD-101\u4e2d\uff0cTIM\u80bd\u88ab\u7f16\u7801\u5728CAR-T\u65c1\u8fb9\uff0c\u53ea\u9700\u5f02\u57fa\u56e0T\u7ec6\u80de\u901a\u8fc7\u4e00\u6b65\u8f6c\u5bfc\u5373\u53ef\u751f\u6210\u3002CYAD-101\u7684\u4f18\u70b9\u5728\u4e8e\u4f7f\u7528\u4e86\u4e0eCelyad\u5728\u4e34\u5e8a\u81ea\u4f53CAR-T\u7ec6\u80de\u4ea7\u54c1\u4e0a\u7684\u6210\u719f\u5de5\u827a\u6781\u4e3a\u76f8\u4f3c\u7684\u5236\u9020\u5de5\u827a\u3002CYAD-101\u662f\u975e\u57fa\u56e0\u7f16\u8f91\u7684\u540c\u79cd\u5f02\u4f53CAR-T\u5bb6\u65cf\u7684\u7b2c\u4e00\u4e2a\u4ea7\u54c1\uff0c\u4ee5\u7ed3\u76f4\u80a0\u764c\u4e3a\u76ee\u6807\uff0c\u7531Celyad\u7814\u53d1\u7684SHRINK\u81ea\u4f53CAR-T\u9879\u76ee\u4e3a\u57fa\u7840\u53d1\u5c55\u800c\u6765\u3002\uff08Celyad\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                3<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u4ee3\u8c22\u7cfb\u7edf\u75be\u75c5<\/span><\/strong><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u67086\u65e5\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u53d1\u8868\u65b0\u7684SLC13A5\u6291\u5236\u5242<\/span><\/p>\n<\/section>\n

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                                \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u8fd1\u65e5\u53d1\u73b0\u4e86\u4e00\u7c7b\u78fa\u9170\u80fa\u884d\u751f\u7269\u4f5c\u4e3a\u6eb6\u8d28\u8f7d\u4f53\u5bb6\u65cf13\u6210\u5458A5\uff08SLC13A5\uff09\u6291\u5236\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u4ee3\u8c22\u6027\u75be\u75c5\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u3002\u572814C\u6807\u8bb0\u7684\u67e0\u6aac\u9178\u76d0\u6444\u53d6\u8bd5\u9a8c\u4e2d\uff0c\u4ee3\u8868\u5316\u5408\u7269\u80fd\u591f\u6291\u5236\u91cd\u7ec4\u4eba\u809d\u764cHepG2\uff08\u8868\u8fbe\u5185\u6e90\u6027SLC13A5\uff09\u548c\u8fc7\u8868\u8fbehSLC13A5\u7684HEK-293\u7ec6\u80de\u7684\u67e0\u6aac\u9178\u6444\u53d6\uff08IC50\u5206\u522b\u4e3a0.022\u548c0.056 mcM\uff09\u3002\u57283H\u6807\u8bb0\u7684\u7518\u6c28\u9178\u6444\u53d6\u8bd5\u9a8c\u4e2d\uff0c\u8fc7\u8868\u8fbeGlyT2\u7684\u91cd\u7ec4\u4ebaHEK-293\u7ec6\u80de\u4e5f\u8868\u73b0\u51fa\u7518\u6c28\u9178\u6444\u53d6\u7684\u6291\u5236\uff08IC50 > 100 mcM\uff09\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018104220\uff09\u3002<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u56fe\u4e3a\u4e13\u5229WO 2018104220\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670818\u65e5\uff0cPoxel\u516c\u53f8\u6cbb\u7597NASH\u7684\u5019\u9009\u65b0\u836fPXL-770\u53d6\u5f97\u79ef\u6781\u7684IB\u671f\u4e34\u5e8a\u7ed3\u679c<\/span><\/p>\n<\/section>\n

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                                Poxel\u516c\u53f8\u62ab\u9732\u4e86\u5019\u9009\u65b0\u836fPXL-770\u7684\u4e24\u9879IB\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff0c\u8fd9\u662f\u4e00\u79cd\u539f\u521b\u7684\u53e3\u670d\u817a\u82f7\u5355\u78f7\u9178\u6fc0\u6d3b\u86cb\u767d\u6fc0\u9176\uff08AMPK\uff09\u6fc0\u6d3b\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u3002\u8be5\u7814\u7a76\u5305\u62ec\u4e86\u4e00\u9879\u5242\u91cf\u722c\u5761\u7814\u7a76\u548c\u4e00\u9879\u836f\u7269-\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7814\u7a76\uff08ClinicalTrials.gov\u7f16\u53f7NCT03395470\uff09\u3002\u5242\u91cf\u722c\u5761\u7814\u7a76\u5305\u62ec48\u540d\u53d7\u8bd5\u8005\uff0c\u572860 \u2013 500mg\u76846\u4e2a\u5242\u91cf\u7ec4\u4e2d\u5b9e\u65bd\u6bcf\u59291-2\u6b21\u7ed9\u836f\uff0c\u8bc4\u4f30PXL-770\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u65e0\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u6216\u4e0d\u826f\u4e8b\u4ef6\u5bfc\u81f4\u7684\u7528\u836f\u4e2d\u65ad\u3002PXL-770\u7684\u8010\u53d7\u6027\u5f88\u597d\uff0c\u5b8c\u6210\u6700\u9ad8\u5242\u91cf\u4e3a500mg\u7684\u7ed9\u836f\u540e\u7531\u4e8e\u6ca1\u6709\u8fbe\u5230\u4efb\u4f55\u5b89\u5168\u8fb9\u754c\u800c\u7ed3\u675f\u7814\u7a76\u3002\u5bf9\u6240\u6709\u5242\u91cf\u7ec4\u7684\u5fc3\u7535\u56fe\u7814\u7a76\u663e\u793a\uff0cPXL-770\u4e0d\u8bf1\u5bfcTQT\u95f4\u9694\u5ef6\u957f\uff0c\u4e5f\u4e0d\u5f71\u54cd\u4efb\u4f55\u5176\u4ed6\u5fc3\u7535\u56fe\u53c2\u6570\u3002PXL-770\u7684Cmax\u548cAUC\u4e0e\u5242\u91cf\u5448\u7ebf\u6027\u76f8\u5173\uff0c\u5728\u6700\u9ad8\u5242\u91cf\u65f6\u5448\u9971\u548c\u8d8b\u52bf\u3002\u6b64\u5916\uff0c\u8fd8\u5bf9\u4ed6\u6c40\u7c7b\u836f\u7269\u745e\u8212\u4f10\u4ed6\u6c40\u8fdb\u884c\u4e86\u836f\u7269-\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7814\u7a76\u3002\u745e\u8212\u4f10\u4ed6\u6c40\u4f5c\u4e3a\u4e00\u79cd\u6709\u673a\u9634\u79bb\u5b50\u8f6c\u8fd0\u591a\u80bd\uff08OATP\uff09\u8f6c\u8fd0\u4f53\u7684\u63a2\u9488\u5e95\u7269\uff0c\u53ef\u4ee5\u5f15\u8d77\u836f\u7269-\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3002\u5728\u8be5\u9879\u7814\u7a76\u4e2d\uff0c12\u540d\u53d7\u8bd5\u8005\u6bcf\u5929\u670d\u7528250\u6beb\u514b\u7684PXL-770\u548c\u6807\u51c6\u5242\u91cf\u7684\u745e\u8212\u4f10\u4ed6\u6c40\u3002\u7ed3\u679c\u8868\u660e\uff0cPXL-770\u4e0eOATP\u57fa\u8d28\u4e4b\u95f4\u4e0d\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7ed3\u679c\uff0c\u516c\u53f8\u6b63\u51c6\u5907\u542f\u52a8\u4e00\u4e2aIIa\u671f\u7684\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76\uff0c\u7528\u4ee5\u6cbb\u7597NASH\u3002\u5c06\u5305\u62ec\u4e00\u9879\u968f\u673a\u53cc\u76f2\u6709\u5b89\u6170\u5242\u5bf9\u7167\u7684\u5e73\u884c\u7814\u7a76\uff0c\u5728\u7ea6100\u540d\u60a3\u6216\u4e0d\u60a32\u578b\u7cd6\u5c3f\u75c5\u7684\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\uff08NAFLD\uff09\u60a3\u8005\u4e2d\u8bc4\u4f30PXL-770\u76f8\u5bf9\u4e8e\u5b89\u6170\u5242\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u4e3b\u8981\u7ec8\u70b9\u5c06\u88ab\u5b9a\u4e49\u4e3a\u6cbb\u759712\u5468\u540e\u7684\u809d\u8102\u80aa\u542b\u91cf\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u7684\u53d8\u5316\u7387\u548c\u4f7f\u7528MRI\u8bc4\u4f30\u7684\u8d28\u5b50\u5bc6\u5ea6\u8102\u80aa\u5206\u6570\u3002\u8be5\u7814\u7a76\u8fd8\u5c06\u63a2\u8ba8PXL-770\u5728\u8102\u4ee3\u8c22\u548c\u8840\u7cd6\u63a7\u5236\u4e2d\u7684\u4f5c\u7528\uff0c\u53e6\u5916\u8fd8\u5c06\u5305\u62ec\u4e00\u4e2a\u8bc4\u4f30PXL-770\u6291\u5236\u8102\u80aa\u5206\u89e3\u548c\u809d\u65b0\u751f\u8102\u80aa\u751f\u6210\u7684\u673a\u5236\u7814\u7a76\u3002\u8fd9\u9879IIa\u671f\u7814\u7a76\u5c06\u5728\u4eca\u5e74\u4e0b\u534a\u5e74\u8ba1\u5212\u5f00\u5c55\u51c6\u5907\u5de5\u4f5c\uff0c\u5305\u62ecIND\u5907\u6848\uff0c\u836f\u54c1\u751f\u4ea7\u548c\u4e34\u5e8a\u5730\u70b9\u7684\u786e\u8ba4\u3002\uff08Poxel\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670819\u65e5\uff0c\u80f0\u817a\u03b2\u7ec6\u80de\u80fd\u591f\u5236\u9020\u5e76\u5206\u6ccc\u81ea\u8eab\u514d\u75ab\u591a\u80bd<\/span><\/p>\n<\/section>\n

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                                By Anette Breindl, Senior Science Editor<\/span><\/p>\n

                                \u5723\u8def\u6613\u65af\u534e\u76db\u987f\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u57282018\u5e747\u670819\u65e5\u7684\u300a\u81ea\u7136\u300b\u6742\u5fd7\u4e0a\u62a5\u9053\uff0c\u5f15\u53d11\u578b\u7cd6\u5c3f\u75c5\u7684\u81ea\u8eab\u514d\u75ab\u591a\u80bd\u662f\u7531\u80f0\u817a\u03b2\u7ec6\u80de\u81ea\u8eab\u4ea7\u751f\u7684\uff0c\u5e76\u901a\u8fc7\u80de\u5410\u4f5c\u7528\u91ca\u653e\u5230\u8840\u6db2\u4e2d\u3002\u03b2\u7ec6\u80de\u901a\u8fc7\u5206\u6ccc\u541e\u566c\u4f5c\u7528\uff08crinophagy\uff09\u8fdb\u884c\u5bf9\u80f0\u5c9b\u7d20\u7684\u8d28\u91cf\u63a7\u5236\uff0c\u5176\u526f\u4f5c\u7528\u662f\u4ea7\u751f\u591a\u80bd\uff0c\u8fd9\u4e9b\u80bd\u6bb5\u5728\u767d\u7ec6\u80de\u6297\u539f\uff08HLA\uff09\u7684\u67d0\u4e9b\u53d8\u5f02\u7684\u4e2a\u4f53\u4e2d\u5177\u6709\u514d\u75ab\u539f\u6027\uff0c\u662f\u514d\u75ab\u7ec6\u80de\u7684\u6297\u539f\u3002<\/span><\/p>\n

                                \u8be5\u8bba\u6587\u7684\u4f5c\u8005Emil Unanue\u662f\u5723\u8def\u6613\u65af\u534e\u76db\u987f\u5927\u5b66\u7684\u75c5\u7406\u5b66\u548c\u514d\u75ab\u5b66\u6559\u6388\uff0c\u4ed6\u544a\u8bc9\u300aBioWorld Science\u300b\uff1a\u201c\u80f0\u817a\u4e0d\u65ad\u5730\u5411\u8840\u6db2\u548c\u7ec4\u7ec7\u4e2d\u64ad\u4e0b\u79cd\u5b50\uff0c\u6b63\u662f\u8fd9\u4e9b\u7269\u8d28\u5bfc\u81f4\u4e861\u578b\u7cd6\u5c3f\u75c5\u201d\u3002\u5728\u4e4b\u524d\u7684\u7814\u7a76\u4e2d\uff0c\u4ed6\u548c\u4ed6\u7684\u56e2\u961f\u5df2\u7ecf\u8bc1\u660e\uff0c\u57281\u578b\u7cd6\u5c3f\u75c5\u4e2d\u8d77\u81ea\u8eab\u514d\u75ab\u4f5c\u7528\u7684\u4e00\u79cd\u591a\u80bd\uff0c\u6765\u81ea\u4e8e\u80f0\u5c9b\u7d20\u672c\u8eab\u3002\u5177\u4f53\u6765\u8bf4\uff0c\u8fd9\u79cd\u591a\u80bd\u7684B\u94fe12-20\u6c28\u57fa\u9178\u7247\u6bb5\u6b63\u662f\u80f0\u5c9b\u7d20B\u94fe\u7684\u4e00\u4e2a\u7247\u6bb5\u3002\u201c\u8fd9\u5c31\u5f15\u51fa\u4e86\u4e00\u4e2a\u95ee\u9898\uff0c\u8fd9\u4e9b\u80bd\u6765\u81ea\u54ea\u91cc\uff1f\u201d\u4ed6\u8bf4\uff0c\u201c\u8fd9\u5c31\u662f\u6211\u4eec\u5f00\u5c55\u8fd9\u9879\u7814\u7a76\u7684\u539f\u56e0\u3002\u201d<\/span><\/p>\n

                                Unanue\u8bf4\uff0c\u7531\u4e8e\u03b2\u7ec6\u80de\u4e0d\u65ad\u9700\u8981\u5bf9\u98df\u7269\u7684\u6444\u5165\u505a\u51fa\u53cd\u5e94\uff0c\u201c\u7ec6\u80de\u4e2d\u98df\u7269\u9897\u7c92\u7684\u6570\u91cf\u603b\u662f\u8fc7\u5269\u7684\uff0c\u03b2\u7ec6\u80de\u4f1a\u542f\u52a8\u5206\u6ccc\u541e\u566c\u673a\u5236\uff0c\u5982\u679c\u8fd9\u4e9b\u9897\u7c92\u63a5\u8fd1\u4fdd\u8d28\u671f\u7684\u5c3d\u5934\uff0c\u5b83\u4eec\u5c31\u4f1a\u964d\u89e3\u8fd9\u4e9b\u9897\u7c92\u3002\u201d\u4ed6\u7684\u56e2\u961f\u53d1\u73b0\uff0c\u5728\u5206\u6ccc\u541e\u566c\u8fc7\u7a0b\u4e2d\uff0c\u7531\u80f0\u5c9b\u7d20\u4ea7\u751f\u7684\u514d\u75ab\u591a\u80bd\u4f1a\u88ab\u91ca\u653e\u5230\u8840\u6db2\u4e2d\uff0c\u540c\u65f6\u03b2\u7ec6\u80de\u4e5f\u5728\u91ca\u653e\u80f0\u5c9b\u7d20\uff0c\u6b64\u5916\u8fd8\u6709\u5176\u4ed6\u7684\u591a\u80bd\u4f1a\u4ece\u7ec6\u80de\u4e2d\u91ca\u653e\u51fa\u6765\u3002\u201c\u8fd9\u662f\u4e00\u79cd\u6b63\u5e38\u751f\u7406\u53cd\u5e94\uff0c\u800c\u4e0d\u662f\u75c5\u7406\u53cd\u5e94\u3002\u5b83\u53d1\u751f\u5728\u6240\u6709\u7684\u5c0f\u9f20\u4e2d\uff0c\u4e0d\u8bba\u662f\u5426\u60a3\u6709\u7cd6\u5c3f\u75c5\u3002\u201d<\/span><\/p>\n

                                Unanue\u548c\u4ed6\u7684\u56e2\u961f\u57286\u4e2a\u5668\u5b98\u6350\u732e\u8005\u7684\u80f0\u817a\u7ec4\u7ec7\u4e2d\u8bc1\u5b9e\u4e86\u4e0a\u8ff0\u89c2\u70b9\u3002\u201c\u6211\u4eec\u5728\u8001\u9f20\u8eab\u4e0a\u7684\u53d1\u73b0\u4e5f\u9002\u7528\u4e8e\u4eba\u4f53\uff0c\u201d\u4ed6\u8bf4\uff0c\u201c\u4eba\u4f53\u6709\u8001\u9f20\u8eab\u4e0a\u53d1\u73b0\u7684\u76f8\u4f3c\u7684\u5c0f\u6ce1\uff0c\u4e5f\u6709\u8001\u9f20\u8eab\u4e0a\u53d1\u73b0\u7684\u4e00\u6837\u7684\u591a\u80bd\u3002\u81f3\u4e8e\u7ec6\u80de\u4e3a\u4ec0\u4e48\u5206\u6ccc\u8fd9\u4e9b\u591a\u80bd\uff0cUnanue\u8bf4\uff1a\u201c\u76ee\u524d\u6211\u4eec\u8fd8\u4e0d\u77e5\u9053\u3002\u6211\u4eec\u5728\u75be\u75c5\u80cc\u666f\u4e0b\u5bf9\u5b83\u4eec\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u4f46\u5b83\u4eec\u53ef\u80fd\u5177\u6709\u751f\u7406\u4f5c\u7528\uff0c\u8fd9\u662f\u6211\u4eec\u73b0\u5728\u8981\u7814\u7a76\u7684\u201d\u3002\u4ed6\u7684\u56e2\u961f\u8bc1\u660e\uff0c\u80f0\u817a\u4ea7\u751f\u7684\u591a\u80bd\u4f1a\u6e90\u6e90\u4e0d\u65ad\u5730\u8fdb\u5165\u6240\u6709\u7ec4\u7ec7\uff0c\u5e76\u88ab\u6dcb\u5df4\u7ed3\u548c\u813e\u810f\u6355\u83b7\u3002\u5728\u90a3\u91cc\uff0c\u5b83\u4eec\u4f1a\u5728\u9057\u4f20\u6613\u611f\u5c0f\u9f20\u4e2d\u8bf1\u5bfc\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/p>\n

                                \u8fd9\u9879\u7814\u7a76\u8ba9\u4eba\u4eec\u5bf9\u81ea\u8eab\u514d\u75ab\u5728\u7cd6\u5c3f\u75c5\u4e2d\u7684\u89e6\u53d1\u6709\u4e86\u65b0\u7684\u8ba4\u8bc6\uff0c\u53ef\u80fd\u8fd8\u6709\u5176\u4ed6\u7684\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002\u6fc0\u7d20\u817a\u4f53\uff0c\u5982\u7532\u72b6\u817a\u548c\u8111\u5782\u4f53\uff0c\u603b\u662f\u4ea7\u751f\u548c\u964d\u89e3\u8fc7\u91cf\u7684\u8377\u5c14\u8499\uff0cUnanue\u8bf4\uff1a\u201c\u9664\u4e86\u91ca\u653e\u6fc0\u7d20\u5916\uff0c\u5b83\u4eec\u8fd8\u53ef\u80fd\u628a\u67d0\u4e9b\u80bd\u91ca\u653e\u5230\u8840\u6db2\u4e2d\u3002\u201d\u540c\u6837\u7684\u673a\u5236\u4e5f\u53ef\u80fd\u5728\u8bf8\u5982\u7ed3\u80a0\u708e\u548c\u591a\u53d1\u6027\u786c\u5316\u7b49\u75be\u75c5\u7684\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u4e2d\u53d1\u6325\u4f5c\u7528\uff0c\u8fd9\u4e9b\u75be\u75c5\u7684\u7279\u5f81\u662f\u5bf9\u9ad3\u9798\u7684\u514d\u75ab\u53cd\u5e94\u4f7f\u9ad8\u901f\u795e\u7ecf\u5143\u901a\u8baf\u6210\u4e3a\u53ef\u80fd\u3002\u201c\u8fd9\u4e9b\u9ad3\u9798\u86cb\u767d\u662f\u5982\u4f55\u88ab\u5448\u9012\u7ed9\u514d\u75ab\u7cfb\u7edf\u7684\uff1f\u201dUnanue\u6307\u51fa\uff0c\u201c\u6211\u4eec\u5fc5\u987b\u5173\u6ce8\u4ece\u7ec6\u80de\u4e2d\u91ca\u653e\u51fa\u6765\u7684\u5c0f\u80bd\uff0c\u8fd9\u4e9b\u80bd\u5b9e\u9645\u4e0a\u53ef\u80fd\u4e0e\u81ea\u8eab\u514d\u75ab\u76f8\u5173\u3002\u8fd9\u662f\u6211\u4eec\u9700\u8981\u5f00\u59cb\u601d\u8003\u7684\u95ee\u9898\uff0c\u201d\u4ed6\u8bf4\uff0c\u201c\u6211\u4e00\u76f4\u5728\u601d\u8003\u8fd9\u4e2a\u95ee\u9898\u3002\u201d<\/span><\/p>\n

                                \u5728\u4e34\u5e8a\u4e0a\uff0c\u8fd9\u4e9b\u53d1\u73b0\u6709\u6f5c\u529b\u7ed9\u60a3\u67091\u578b\u7cd6\u5c3f\u75c5\u98ce\u9669\u7684\u513f\u7ae5\u5efa\u7acb\u65e9\u671f\u9884\u8b66\u7cfb\u7edf\u3002\u6709\u7cd6\u5c3f\u75c5\u5bb6\u65cf\u53f2\u7684\u513f\u7ae5\u60a3\u7cd6\u5c3f\u75c5\u7684\u98ce\u9669\u8f83\u9ad8\u3002\u5f53\u8461\u8404\u7cd6\u6c34\u5e73\u663e\u793a\u51fa\u95ee\u9898\u65f6\uff0c\u5927\u591a\u6570\u80f0\u5c9b\u7ec6\u80de\u5df2\u7ecf\u88ab\u7834\u574f\u3002\u800c\u82e5\u80fd\u901a\u8fc7\u76d1\u6d4b\u8840\u6db2\u4e2d\u591a\u80bd\u7684\u6c34\u5e73\u548c\u514d\u75ab\u53cd\u5e94\uff0c\u201c\u4eba\u4eec\u53ef\u4ee5\u77e5\u9053\u75be\u75c5\u662f\u4f55\u65f6\u5f00\u59cb\u7684\u3002\u201d\uff08Wan, X. et al. Nature 2018, Advanced publication\uff09\u3002<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670830\u65e5\uff0c\u9aa8\u7a33\u6001\u4e2d\u4fe1\u53f7\u86cb\u767d4D\u548c3A\u7684\u8868\u8fbe\u53d7\u817a\u82f7A2A\u53d7\u4f53\u7684\u8c03\u63a7<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n
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                                \u4e00\u4e9b\u8f74\u7a81\u5f15\u5bfc\u86cb\u767d\uff0c\u5982\u4fe1\u53f7\u86cb\u767dsemaphorins\uff08Sema\uff09\u3001\u8425\u517b\u56e0\u5b50\uff08neutrophins\uff09\u3001\u751f\u957f\u56e0\u5b50\uff08ephorins\uff09\u3001\u5bfc\u5411\u56e0\u5b50\uff08netrins\uff09\u548c\u5b83\u4eec\u7684\u53d7\u4f53\uff0c\u80fd\u591f\u5728\u9aa8\u7a33\u6001\u4e2d\u53c2\u4e0e\u7834\u9aa8\u7ec6\u80de\u548c\u6210\u9aa8\u7ec6\u80de\u4e4b\u95f4\u7684\u6c9f\u901a\u3002\u4fe1\u53f7\u86cb\u767dSema4D\u548cSema3A\u662f\u4e00\u7c7b\u5206\u6ccc\u548c\u8de8\u819c\u86cb\u767d\u7684\u5927\u5bb6\u65cf\uff0c\u5176\u4e2d\u4e00\u4e9b\u5728\u8f74\u7a81\u5f15\u5bfc\u8fc7\u7a0b\u4e2d\u8d77\u7740\u6392\u65a5\u4fe1\u53f7\u7684\u4f5c\u7528\u3002\u7531\u4e8e\u817a\u82f7A2A\u53d7\u4f53\uff08A2AR\uff09\u7684\u523a\u6fc0\u80fd\u540c\u65f6\u8c03\u8282\u7834\u9aa8\u7ec6\u80de\u548c\u6210\u9aa8\u7ec6\u80de\u529f\u80fd\uff0c\u7ebd\u7ea6\u5927\u5b66\u6717\u683c\u5c3c\u533b\u5b66\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u6700\u8fd1\u53d1\u8868\u7684\u4e00\u7bc7\u8bba\u6587\uff0c\u8bc4\u4f30\u4e86A2AR\u5bf9\u8c03\u8282\u78e8\u635f\u9897\u7c92\u8bf1\u5bfc\u7684\u9aa8\u6eb6\u89e3\u6a21\u578b\u5c0f\u9f20\u7684\u7834\u9aa8\u7ec6\u80de\u548c\u6210\u9aa8\u7ec6\u80de\u8868\u8fbe\u7684\u5f71\u54cd\u3002\u7814\u7a76\u8868\u660e\uff0c\u4e0e\u7a7a\u767d\u5bf9\u7167\u76f8\u6bd4\uff0c\u5728\u9885\u9aa8\u690d\u5165\u78e8\u635f\u9897\u7c92\u7684\u5c0f\u9f20\u4f53\u5185\u4f7f\u7528A2AR\u6fc0\u52a8\u5242\uff08CGS-21680 1mcm\uff09\uff0c\u53ef\u4ee5\u589e\u52a0\u9aa8\u5f62\u6210\uff0c\u51cf\u5c11Sema4D\uff0c\u589e\u52a0Sema3A\u7684\u8868\u8fbe\u3002\u5728\u7834\u9aa8\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\uff0cCGS-21680\u80fd\u591f\u6291\u5236NF-kappa B\u914d\u4f53\u53d7\u4f53\u6fc0\u6d3b\u5242\uff08RANKL\uff09\u8bf1\u5bfc\u7684Sema4D\u7684mRNA\u8868\u8fbe\uff081.3 +\/- 0.3 vs 2.5 +\/- 0.1\u500d\uff0cP < 0.001\uff09\u3002\u76f8\u53cd\u7684\uff0cA2AR\u6fc0\u52a8\u5242\u80fd\u591f\u589e\u52a0PlexinA1\u8868\u8fbe\uff0c\u800c\u4e0d\u5f71\u54cdNeuropilin-1\u3002\u5728\u6210\u9aa8\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\uff0cCGS-21680\u53ef\u4ee5\u589e\u5f3aSema3A\u7684mRNA\u8868\u8fbe\uff088.7 +\/- 0.2\u500d\uff0cP < 0.001\uff09\u3002\u5728\u6210\u9aa8\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\uff0cPlexinB1\u7684mRNA\u589e\u52a0\u4e862\u500d\uff0c\u4f46\u672a\u88abCGS-21680\u6539\u53d8\u3002\u8fd9\u4e9b\u53d8\u5316\u5728\u86cb\u767d\u6c34\u5e73\u5f97\u5230\u4e86\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u3002\u5728\u6210\u9aa8\u7ec6\u80de\u4e2d\uff0cCGS-21680\u964d\u4f4eRANKL\uff0c\u589e\u52a0\u9aa8\u4fdd\u62a4\u7d20\uff08OPG\uff09\u548c\u03b2-\u8fde\u73af\u86cb\u767d\u7684\u6570\u91cf\u3002\u5728\u7834\u9aa8\u7ec6\u80de\u524d\u4f53\u4e2d\uff0cSema4D\u589e\u52a0\u4e86Ras\u540c\u6e90\u57fa\u56e0\u5bb6\u65cf\u6210\u5458A\u7684\u78f7\u9178\u5316\u548c\u7c98\u9644\u6fc0\u9176\u7684\u6fc0\u6d3b\uff0c\u800c\u8fd9\u4e9b\u6548\u5e94\u80fd\u591f\u88abCGS-21680\u6240\u6d88\u9664\u3002\u7efc\u4e0a\u6240\u8bc9\uff0c\u8be5\u7814\u7a76\u8bc1\u5b9eA2AR\u7684\u6fc0\u6d3b\u80fd\u591f\u51cf\u5c11\u7834\u9aa8\u7ec6\u80de\u5206\u6cccSema4D\uff0c\u6291\u5236Sema4D\u4ecb\u5bfc\u7684\u7834\u9aa8\u7ec6\u80de\u6fc0\u6d3b\uff0c\u589e\u52a0\u6210\u9aa8\u7ec6\u80de\u5206\u6cccSema3A\uff0c\u589e\u52a0\u6210\u9aa8\u7ec6\u80de\u5206\u5316\uff0c\u51cf\u5c11\u708e\u75c7\u6027\u9aa8\u6eb6\u89e3\uff0c\u8c03\u63a7\u4e86\u7834\u9aa8\u7ec6\u80de\u548c\u6210\u9aa8\u7ec6\u80de\u7684\u76f8\u4e92\u4f5c\u7528\u3002\uff08Mediero, A. et al. FASEB J 2018, 32(7): 3487\uff09\u3002<\/span><\/p>\n


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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u56fe\u4e3aCGS-21680\u7684\u7ed3\u6784<\/span><\/p>\n


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                                4<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u611f\u67d3<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670817\u65e5\uff0c\u5019\u9009\u836f\u7269baloxavirmarboxil\u5728CAPSTONE-2\u6297\u6d41\u611f\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fbe\u5230\u9996\u8981\u7ec8\u70b9<\/span><\/p>\n<\/section>\n

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                                \u7f57\u6c0f\u65d7\u4e0b\u7684\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u5ba3\u5e03, \u5019\u9009\u836f\u7269baloxavirmarboxil\u7684CAPSTONE-2\u4e34\u5e8a\u7814\u7a76\u7684\u7b2c\u4e09\u9636\u6bb5\u8fbe\u5230\u4e86\u9996\u8981\u7ec8\u70b9\u3002\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86\u8be5\u836f\u7528\u4e8e\u6d41\u611f\u5e76\u53d1\u75c7\u7684\u9ad8\u5371\u4eba\u7fa4\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5e76\u5728\u4e3b\u8282\u70b9\u4e0a\u663e\u793a\u4e86\u6539\u5584\u6d41\u611f\u75c7\u72b6\u7684\u663e\u8457\u4f18\u8d8a\u6027\uff08ClinicalTrials.gov\u7f16\u53f7NCT02949011\uff09\u3002\u7f8e\u56fd\u75be\u75c5\u63a7\u5236\u4e0e\u9884\u9632\u4e2d\u5fc3\uff08CDC\uff09\u5c06\u7f79\u60a3\u4e25\u91cd\u6d41\u611f\u5e76\u53d1\u75c7\u7684\u9ad8\u5371\u4eba\u7fa4\u5b9a\u4e49\u4e3a65\u5c81\u6216\u4ee5\u4e0a\u7684\u6210\u5e74\u4eba\uff0c\u4ee5\u53ca\u60a3\u6709\u54ee\u5598\u3001\u6162\u6027\u80ba\u75c5\u3001\u7cd6\u5c3f\u75c5\u6216\u5fc3\u810f\u75c5\u7b49\u75be\u75c5\u7684\u4eba\u7fa4\u3002\u4e0e\u5b89\u6170\u5242\u548c\u5965\u53f8\u4ed6\u97e6\uff08oseltamivir\uff09\u76f8\u6bd4\uff0cBaloxavirmarboxil\u5728\u91cd\u8981\u7684\u6b21\u8981\u7ec8\u70b9\uff0c\u5305\u62ec\u51cf\u5c11\u75c5\u6bd2\u8131\u843d\u548c\u964d\u4f4e\u4f53\u5185\u75c5\u6bd2\u6c34\u5e73\u65b9\u9762\u4e5f\u8868\u73b0\u51fa\u4e86\u4f18\u8d8a\u7684\u7597\u6548\u3002\u6b64\u5916\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cbaloxavirmarboxil\u663e\u8457\u964d\u4f4e\u4e86\u6d41\u611f\u76f8\u5173\u5e76\u53d1\u75c7\u7684\u53d1\u751f\u7387\u3002Baloxavirmarboxil\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u53d1\u73b0\u5b89\u5168\u6027\u5f02\u5e38\u98ce\u9669\u3002\u5728III\u671fCAPSTONE-1\u7814\u7a76\u4e2d\uff0c\u8be5\u836f\u5df2\u7ecf\u5728\u4e34\u5e8a\u4e0a\u663e\u793a\u51fa\u4f18\u4e8e\u5b89\u6170\u5242\u7684\u663e\u8457\u7597\u6548\uff08ClinicalTrials.gov\u7f16\u53f7NCT02954354\uff09\u3002\u57fa\u4e8eCAPSTONE-1\u53ca\u5176II\u671f\u7814\u7a76\u6570\u636e\uff0cFDA\u6700\u8fd1\u63a5\u53d7\u4e86baloxavirmarboxil\u7684NDA\u7533\u8bf7\u5e76\u5bf9\u5176\u6388\u4e88\u4e86\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\uff0c\u8be5\u836f\u5c06\u4f5c\u4e3a\u4e00\u79cd\u53e3\u670d\u5236\u5242\u7528\u4e8e12\u5c81\u53ca12\u5c81\u4ee5\u4e0a\u4eba\u7fa4\u7684\u6025\u6027\u3001\u7b80\u5355\u6d41\u611f\u7684\u6cbb\u7597\uff0c\u9884\u8ba1\u57282018\u5e7412\u670824\u65e5\u524d\u505a\u51fa\u5ba1\u6279\u51b3\u5b9a\u3002Baloxavirmarboxil\u662f\u7531\u76d0\u91ce\u4e49\u5236\u836f\u682a\u5f0f\u4f1a\u793e\u53d1\u73b0\u548c\u5f00\u53d1\u7684\uff0c\u5728\u65e5\u672c\u7684\u5546\u6807\u540d\u4e3aXofluza\u3002\uff08\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/span><\/p>\n


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                                \u56fe\u4e3aBaloxavirmarboxil\u7684\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                5<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u8840\u6db2\u53ca\u51dd\u8840\u75be\u75c5<\/span><\/strong><\/p>\n


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                                2018\u5e747\u670811\u65e5\uff0c\u80be\u6027\u8d2b\u8840\u6cbb\u7597\uff1a\u65b0\u578b\u53e3\u670dHIF\u812f\u6c28\u9178\u7f9f\u5316\u9176\u6291\u5236\u5242\u80fd\u591f\u4fc3\u8fdb\u556e\u9f7f\u7c7b\u52a8\u7269EPO\u7684\u4ea7\u751f<\/p>\n<\/section>\n

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                                \u5728\u6162\u6027\u80be\u75c5\u60a3\u8005\u4e2d\uff0c\u80be\u810f\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff08EPO\uff09\u751f\u6210\u7684\u51cf\u5c11\u4f1a\u5bfc\u81f4\u80be\u6027\u8d2b\u8840\u7684\u53d1\u751f\uff0c\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\u4f1a\u968f\u7740\u75c5\u60c5\u7684\u53d1\u5c55\u800c\u964d\u4f4e\u3002\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\u80fd\u63d0\u9ad8\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\uff0c\u51cf\u7f13\u80be\u529f\u80fd\u7684\u4e0b\u964d\u3002\u7136\u800c\uff0c\u6ce8\u5c04\u6cbb\u7597\u7684\u4e0d\u4fbf\u3001\u6602\u8d35\u7684\u6210\u672c\u548c\u6297\u4f53\u7684\u5f62\u6210\u4f1a\u5f71\u54cd\u5176\u4f7f\u7528\u548c\u7597\u6548\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u65b0\u7684\u53e3\u670d\u5c0f\u5206\u5b50\u836f\u7269\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u81ea\u7136EPO\u7684\u4ea7\u751f\u662f\u7531\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff08HIF\uff09\u8bf1\u5bfc\u7684\uff0c\u5728\u6b63\u5e38\u6c27\u6c14\u6c34\u5e73\u4e0b\uff0cEPO\u7531HIF\u88ab\u812f\u6c28\u9178\u7f9f\u5316\u9176\uff08PHD\uff09\u964d\u89e3\u6240\u4ea7\u751f\u3002PHD\u6291\u5236\u5242\u6216\u53ef\u901a\u8fc7\u7a33\u5b9aHIF\u4f5c\u4e3a\u6cbb\u7597\u80be\u6027\u8d2b\u8840\u7684\u4e00\u79cd\u66ff\u4ee3\u65b9\u6cd5\u3002\u6765\u81eaTaisho Pharmaceutical\u7684\u7814\u7a76\u4eba\u5458\u6700\u8fd1\u57fa\u4e8e\u5df2\u77e5\u6291\u5236\u5242\u7684\u7ed3\u6784\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u7684PHD\u6291\u5236\u5242\uff0c\u6709\u671b\u4f5c\u4e3a\u53e3\u670d\u6cbb\u7597\u80be\u6027\u8d2b\u8840\u7684\u836f\u7269\u3002\u6839\u636ePHD\u6291\u5236\u6d3b\u6027\u3001\u4eb2\u8102\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u5316\u5408\u7269TP-0463518\u88ab\u9009\u4e3a\u4e34\u5e8a\u5019\u9009\u5316\u5408\u7269\u3002\u53e3\u670d\u8be5\u5316\u5408\u7269\u80fd\u591f\u4fc3\u8fdb\u5c0f\u9f20\u548c\u5927\u9f20EPO\u4ea7\u751f\u3002\u8be5\u5316\u5408\u7269\u5728\u4eba\u4f53\u5185\u7684\u9884\u671f\u534a\u8870\u671f\u4e3a1.3-5.6\u5c0f\u65f6\uff0c\u6545\u6bcf\u65e5\u4e00\u6b21\u7684\u7ed9\u836f\u8db3\u4ee5\u4ea7\u751f\u9884\u671f\u7684\u6548\u679c\uff0c\u4e14\u6709\u52a9\u4e8e\u51cf\u5c11\u4e0d\u826f\u4e8b\u4ef6\u3002\uff08Hamada, M. et al. Bioorg Med Chem Lett 2018, 28(10): 1725\uff09\u3002<\/span><\/p>\n


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                                \u56fe\u4e3a\u5316\u5408\u7269TP-0463518\u7684\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670812\u65e5\uff0c\u5916\u6ccc\u4f53\u5728\u7cd6\u5c3f\u75c5\u4e2d\u91ca\u653e\u7cbe\u6c28\u9178\u9176<\/span><\/p>\n<\/section>\n

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                                \u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u5916\u6ccc\u4f53\u91ca\u653e\u7684\u7cbe\u6c28\u9178\u9176\u5728\u7cd6\u5c3f\u75c5\u5f15\u8d77\u7684\u8840\u7ba1\u529f\u80fd\u969c\u788d\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u5fc3\u8840\u7ba1\u75be\u75c5\u662f\u7cd6\u5c3f\u75c5\u7684\u4e3b\u8981\u5e76\u53d1\u75c7\u4e4b\u4e00\u3002\u9ad8\u6c34\u5e73\u7684\u7cbe\u6c28\u9178\u9176\uff0c\u4e00\u79cd\u4e0e\u4e00\u6c27\u5316\u6c2e\u5408\u9176\u7ade\u4e89\u7684\u5408\u6210\u9176\uff0c\u80fd\u591f\u901a\u8fc7\u5e72\u6270\u8840\u7ba1\u677e\u5f1b\u673a\u5236\u800c\u5bfc\u81f4\u8840\u7ba1\u529f\u80fd\u969c\u788d\u3002\u8be5\u7814\u7a76\u7ec4\u53d1\u73b0\uff0c\u7cd6\u5c3f\u75c5\u6a21\u578b\u5c0f\u9f20\u7684\u8840\u6e05\u5916\u6ccc\u4f53\u4e2d\u542b\u6709\u9ad8\u6c34\u5e73\u7684\u7cbe\u6c28\u9178\u9176\uff0c\u800c\u8fd9\u4e9b\u5916\u6ccc\u4f53\u88ab\u975e\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u7684\u4e3b\u52a8\u8109\u8840\u7ba1\u7ec6\u80de\u5438\u6536\u540e\uff0c\u80fd\u591f\u5f15\u8d77\u975e\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u7684\u8840\u7ba1\u529f\u80fd\u969c\u788d\u3002\u8be5\u53d1\u73b0\u8868\u660e\uff0c\u9020\u6210\u8840\u7ba1\u529f\u80fd\u969c\u788d\u7684\u7f18\u7531\u662f\u7cbe\u6c28\u9178\u9176\uff0c\u800c\u4e0d\u662f\u5916\u6ccc\u4f53\u4e2d\u5927\u91cf\u5b58\u5728\u7684microRNA\u3002\uff08Zhang, H. et al. Proc Natl AcadSci U S A 2018, Advanced publication\uff09\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                6<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u808c\u8089\u9aa8\u9abc\u548c\u7ed3\u7f14\u7ec4\u7ec7\u75be\u75c5<\/span><\/strong><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670819\u65e5\uff0c\u7b2c\u4e00\u4e09\u5171\u53ca\u5176\u5408\u4f5c\u8005\u53d1\u8868TNSALP\u6291\u5236\u5242\u4e13\u5229<\/span><\/p>\n<\/section>\n

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                                \u7b2c\u4e00\u4e09\u5171\u5236\u836f\u548cSanford Burnham Prebys\u533b\u5b66\u7814\u7a76\u6240\u5408\u4f5c\u53d1\u73b0\u4e86\u4e00\u7c7b\u78fa\u80fa\u7c7b\u5316\u5408\u7269\u4f5c\u4e3a\u7ec4\u7ec7\u975e\u7279\u5f02\u6027\u78b1\u6027\u78f7\u9178\u9176\u540c\u5de5\u9176\uff08TNSALP\uff09\u6291\u5236\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u5f39\u6027\u5047\u9ec4\u7624\uff0c\u5f02\u4f4d\u9499\u5316\uff0c\u5173\u8282\u548c\u52a8\u8109\u9499\u5316\uff0c\u5a74\u513f\u5168\u8eab\u52a8\u8109\u9499\u5316\uff0c\u540e\u7eb5\u97e7\u5e26\u9aa8\u5316\uff0c\u9ec4\u97e7\u5e26\u9aa8\u5316\uff0c\u4e3b\u52a8\u8109\u74e3\u72ed\u7a84\u548c\u8840\u7ba1\u9499\u5316\u7b49\u75be\u75c5\u3002\u4ee3\u8868\u5316\u5408\u7269\u7684\u6e38\u79bb\u78b1\u53ef\u4ee5\u6291\u5236COS-1\u7ec6\u80de\u4e2dTNSALP\u7684\u6d3b\u6027\uff08IC50 = 1.4 nM\uff09\uff1b\u8fd8\u80fd\u6291\u5236B6\u5c0f\u9f20\u8840\u6d46\u4e2dALP\u7684\u6d3b\u6027\uff080.3 mg\/kg\u53e3\u670d6 \u5c0f\u65f6\u540e\u7684\u5e73\u5747\u6291\u5236\u7387\u4e3a65.5%\uff09\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018119444\uff09\u3002<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u56fe\u4e3aWO 2018119444\u4e13\u5229\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670819\u65e5\uff0cSyk\u6fc0\u9176\u7684\u9009\u62e9\u6027\u6291\u5236\u5242TAS-05567\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u548c\u8fc7\u654f\u6027\u75be\u75c5<\/span><\/p>\n<\/section>\n

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                                \u5728\u4e00\u4e9b\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5982\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u548c\u514d\u75ab\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u4e2d\uff0c\u7531\u81ea\u8eab\u6297\u539f\u548c\u81ea\u8eab\u6297\u4f53\u5f62\u6210\u7684\u514d\u75ab\u590d\u5408\u7269\u901a\u8fc7Fc-gamma\u53d7\u4f53\u6fc0\u6d3b\u6548\u5e94\u7ec6\u80de\uff0c\u4ece\u800c\u5bfc\u81f4\u6162\u6027\u708e\u75c7\u3002\u56e0\u6b64\uff0cFc-gamma\u4fe1\u53f7\u901a\u8def\u662f\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u6f5c\u5728\u9776\u6807\u3002\u5c24\u5176\u662f\u813e\u810f\u916a\u6c28\u9178\u6fc0\u9176\uff08Syk\uff09\u53c2\u4e0e\u7684B\u7ec6\u80de\u53d7\u4f53\uff08BCR\uff09\u548cFc\u53d7\u4f53\u7684\u4e0b\u6e38\u8c03\u63a7\uff0c\u662f\u4fc3\u708e\u4ecb\u8d28\u4ea7\u751f\u548c\u514d\u75ab\u7ec6\u80de\u5206\u5316\u7684\u5173\u952e\u3002\u6765\u81eaTaiho Pharmaceutical\u7684\u7814\u7a76\u4eba\u5458\u6700\u8fd1\u9274\u5b9a\u51fa\u4e00\u4e2a\u9ad8\u5ea6\u9009\u62e9\u6027\u7684Syk\u6291\u5236\u5242TAS-05567\uff0c\u5e76\u8bc4\u4ef7\u4e86\u5b83\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u7684\u6cbb\u7597\u4f5c\u7528\u3002\u4f53\u5916\u7814\u7a76\u8868\u660e\uff0c\u5728191\u4e2a\u6fc0\u9176\u8c31\u8bd5\u9a8c\u4e2d\uff0cTAS-05567\u80fd\u9009\u62e9\u6027\u7684\u6291\u52364\u79cd\u6fc0\u9176\uff0c\u4e14\u5bf9Syk\u6709\u5f88\u9ad8\u7684\u6291\u5236\u6d3b\u6027\u3002\u6b64\u5916\uff0c\u8be5\u5316\u5408\u7269\u80fd\u591f\u51cf\u5c11BCR\u4f9d\u8d56\u7684\u4fe1\u53f7\u8f6c\u5bfc\u548cFcR\u4ecb\u5bfc\u7684\u591a\u79cd\u708e\u75c7\u56e0\u5b50\u5728\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684\u4ea7\u751f\u3002\u5728\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u5927\u9f20\u6a21\u578b\u4e2d\uff0cTAS-05567\u80fd\u4ee5\u6d53\u5ea6\u4f9d\u8d56\u7684\u65b9\u5f0f\u6291\u5236\u540e\u8db3\u80bf\u80c0\uff0c\u4e0e\u7a7a\u767d\u5bf9\u7167\u76f8\u6bd4\u663e\u8457\u964d\u4f4e\u4e86\u7ec4\u7ec7\u75c5\u7406\u5b66\u8bc4\u5206\u3002\u5728\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u5019\u9009\u836f\u7269\u4ee5\u5242\u91cf\u4f9d\u8d56\u7684\u65b9\u5f0f\u963b\u6b62\u4e86\u6297\u8840\u5c0f\u677f\u6297\u4f53\u6ce8\u5c04\u5f15\u8d77\u7684\u8840\u5c0f\u677f\u8ba1\u6570\u4e0b\u964d\u3002\u6b64\u5916\uff0cTAS-05567\u8fd8\u53ef\u6291\u5236IgE\u4ecb\u5bfc\u7684\u52a8\u7269\u8033\u80bf\u80c0\u3002\u4e0a\u8ff0\u7ed3\u679c\u8bc1\u5b9e\u4e86TAS-05567\u4f5c\u4e3a\u9009\u62e9\u6027Syk\u6291\u5236\u5242\u7684\u4f5c\u7528\uff0c\u4f7f\u5176\u5728\u514d\u75ab\u7403\u86cb\u767d\u4ecb\u5bfc\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u5982\u81ea\u8eab\u514d\u75ab\u6216\u8fc7\u654f\u6027\u75be\u75c5\u4e2d\u5177\u6709\u6f5c\u5728\u7684\u5e94\u7528\u4ef7\u503c\u3002\uff08Hayashi, H. et al. J PharmacolExpTher 2018, 366(1): 84\uff09\u3002<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u56fe\u4e3a\u5316\u5408\u7269TAS-5567\u7684\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                7<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n
                                <\/section>\n
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                                \u795e\u7ecf\u7cfb\u7edf\u75be\u75c5<\/span><\/strong><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

                                \n
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                                2018\u5e747\u67083\u65e5\uff0c\u5fb7\u5dde\u5927\u5b66\u7cfb\u7edf\u5408\u6210\u65b0\u7684MAP3K12\u6291\u5236\u5242<\/span><\/p>\n<\/section>\n

                                \n
                                <\/section>\n
                                <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
                                \n
                                \n
                                \n

                                \u5fb7\u514b\u8428\u65af\u5927\u5b66\u7cfb\u7edf\u65e5\u524d\u7533\u8bf7\u4e86\u4e00\u9879\u53cc\u73af\u620a\u70f7\u7c7b[1.1.1]\u5316\u5408\u7269\u4e13\u5229\uff0c\u4f5c\u4e3a\u4e1d\u88c2\u539f\u6fc0\u6d3b\u7684\u86cb\u767d\u6fc0\u9176\u6fc0\u917612\uff08MAP3K12\uff09\u6291\u5236\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u8ba4\u77e5\u969c\u788d\u3001\u795e\u7ecf\u9000\u884c\u6027\u548c\u795e\u7ecf\u75c5\u53d8\u3002\u4ee3\u8868\u5316\u5408\u7269\u53ef\u4ee5\u6291\u5236DNA\u6807\u8bb0\u7684\u4eba\u7c7b\u5168\u957fMAP3K12\u4e0e\u914d\u4f53\u7684\u7ed3\u5408\uff08Kd = 0.11 nM\uff09\u3002\u5728\u8f6c\u67d3\u4e86\u5f3a\u529b\u9709\u7d20\u8bf1\u5bfc\u7684\u4eba\u6e90MAP3K12\u7684HEK-293\u7ec6\u80de\u5b9e\u9a8c\u4e2d\uff0c\u5b83\u6291\u5236\u4e86\u8f6c\u5f55\u56e0\u5b50AP-1\u4e2d63\u53f7\u4e1d\u6c28\u9178\u7684\u78f7\u9178\u5316\uff08IC50 = 12.1 nM\uff09\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018107072\uff09\u3002<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u56fe\u4e3aWO 2018107072\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670817\u65e5\uff0c\u7814\u7a76\u8005\u53d1\u5e03RG-7916\u6cbb\u7597\u810a\u9ad3\u6027\u808c\u8089\u840e\u7f29\u75c7\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e<\/span><\/p>\n<\/section>\n

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                                \u7f57\u6c0f\u548c\u5408\u4f5c\u8005\u62ab\u9732\u4e86risdiplam \uff08RG-7916\uff09\u7528\u4e8e\u6cbb\u7597\u810a\u9ad3\u6027\u808c\u8089\u840e\u7f29\u75c7\uff08SMA\uff09\u7684\u4e24\u9879\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u3002\u4e00\u9879\u540d\u4e3aSUNFISH\u7684\u7814\u7a76\u6d4b\u8bd5\u4e86RG-7916\uff0c\u4e00\u79cd\u8fd0\u52a8\u795e\u7ecf\u5143\u5b58\u6d3b\u86cb\u767d\uff08SMN2\uff09\u8c03\u8282\u5242\uff0c\u7528\u4e8e2\u578b\u62163\u578bSMA \u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\uff08ClinicalTrials.gov\u6807\u53f7NCT02908685\uff09\u3002\u672c\u7814\u7a76\u7684\u7b2c\u4e00\u90e8\u5206\u8bc4\u4f30\u4e8651\u4f8b\u4e0d\u540c\u5242\u91cf\u6c34\u5e73\u7684\u5316\u5408\u7269\u7684\u836f\u52a8\u5b66\u548c\u836f\u6548\u5b66\u6307\u6807\u3002\u7b2c2\u90e8\u5206\u662f168\u4f8b\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7814\u7a76\u3002\u7b2c\u4e00\u90e8\u5206\u7684\u4e34\u5e8a\u7ed3\u679c\u663e\u793a\uff0cRG-7916\u4f7fSMN2\u7684mRNA\u6c34\u5e73\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u589e\u52a0\uff0c\u5168\u8840\u86cb\u767d\u6c34\u5e73\u4e5f\u5448\u73b0\u540c\u6837\u7684\u8d8b\u52bf\uff082.5\u500d\uff09\u3002\u5927\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a\u662f\u6e29\u548c\u7684\uff0c\u836f\u7269\u8010\u53d7\u6027\u826f\u597d\uff0c\u5177\u5907\u5408\u9002\u7684\u836f\u52a8\u5b66\u548c\u836f\u6548\u5b66\u6307\u6807\uff0c\u4e0a\u8ff0\u7ed3\u8bba\u5c06\u6307\u5bfc\u7b2c\u4e8c\u90e8\u5206\u7684\u7528\u836f\u5242\u91cf\u3002\uff08Mercuri, E. et al. 15th IntCongr Neuromuscular Dis (July 6-10, Vienna) 2018, Abst 737\uff09\u3002<\/span><\/p>\n

                                \u53e6\u4e00\u9879\u540d\u4e3aFIREFISH\u7684\u7814\u7a76\u662f\u57281-7\u4e2a\u6708\u5927\u76841\u578bSMA\u5a74\u513f\u4e2d\u8fdb\u884c\u7684\uff08ClinicalTrials.gov\u7f16\u53f7NCT02913482)\u3002\u672c\u7814\u7a76\u7b2c\u4e00\u90e8\u5206\u8003\u5bdf\u4e86\u8be5\u836f\u7269\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\uff08n = 8-24\uff09\u3002\u7ed3\u679c\u663e\u793a\uff0cRG-7916\u53ef\u4f7f\u8840\u6db2\u4e2dSMN\u86cb\u767d\u5242\u91cf\u4f9d\u8d56\u6027\u589e\u52a0\uff08\u4e0e\u57fa\u7ebf\u76f8\u6bd4\uff0c\u6700\u9ad8\u5242\u91cf\u7ec4\u5728\u7b2c4\u5468\u65f6\u4f7fSMN\u86cb\u767d\u589e\u52a06.5\u500d\uff09\u3002\u622a\u6b62\u62a5\u544a\u53d1\u5e03\u65f6\uff0c\u6ca1\u6709\u53d1\u751f\u6c14\u7ba1\u9020\u53e3\u672f\uff0c\u4e0d\u80fd\u541e\u54bd\u6216\u9700\u8981\u6c38\u4e45\u901a\u6c14\u7b49\u4e8b\u4ef6\u62a5\u544a\u3002\u7b2c\u4e8c\u90e8\u5206\u7814\u7a76\u7684\u751f\u5b58\u6570\u636e\u5373\u5c06\u51fa\u7089\u3002\u76ee\u524d\uff0c\u8be5\u836f\u5728\u6240\u6709\u8bd5\u9a8c\u5242\u91cf\u4e0b\u90fd\u5177\u5907\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\uff08Baranello, G. et al. 15th IntCongr Neuromuscular Dis (July 6-10, Vienna) 2018, Abst 752\uff09\u3002<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u56fe\u4e3aRisdiplam\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670827\u65e5\uff0c\u8840\u8111\u5c4f\u969c\u53ef\u900f\u8fc7\u6027\u7684EPO\u6a21\u62df\u7269\u7684\u6162\u6027\u6cbb\u7597\u5bf9AD\u5c0f\u9f20\u6a21\u578b\u6709\u4fdd\u62a4\u4f5c\u7528<\/span><\/p>\n


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                                \u51ef\u514b\u7814\u7a76\u9662\u7684\u7814\u7a76\u4eba\u5458\u53d1\u8868\u4e86\u5173\u4e8e\u4e00\u79cd\u65b0\u7684\u53cc\u7279\u5f02\u6027\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\u2014\u8f6c\u94c1\u86cb\u767d\u53d7\u4f53\u6297\u4f53\u878d\u5408\u86cb\u767d\uff08cTfRMAb-EPO\uff09\uff0c\u4e5f\u88ab\u79f0\u4e3aAGT-m115\uff08ArmaGen\u516c\u53f8\uff09\uff0c\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u4f5c\u7528\u3002APP\/PS1\u8f6c\u57fa\u56e0\u5c0f\u9f20\u5206\u522b\u4f7f\u7528\u751f\u7406\u76d0\u6c34\uff08n = 10\uff09\u6216\u4e0a\u8ff0\u8840\u8111\u5c4f\u969c\u53ef\u900f\u8fc7\u6027\u7684\u878d\u5408\u86cb\u767d\uff08n = 10\uff09\uff0c\u5242\u91cf\u4e3a3mg\/kg \u6bcf3\u54681\u6b21\u8179\u8154\u6ce8\u5c04\uff0c\u6301\u7eed8\u5468\u3002\u6dc0\u7c89\u6837\u86cb\u767d\uff08A\u03b2\uff09\u8d1f\u8377\u6d4b\u91cf\u663e\u793a\uff0c\u4e0e\u751f\u7406\u76d0\u6c34\u76f8\u6bd4\uff0c6E10\u5355\u514b\u9686\u6297\u4f53\uff08MAb\uff09\u9633\u6027\u533a\u7684A\u03b2\u663e\u8457\u964d\u4f4e\uff0c\u5176\u4e2d\u76ae\u5c42\u533a\u663e\u8457\u964d\u4f4e30%\uff08P < 0.05\uff09\uff0c\u6d77\u9a6c\u533a\u663e\u8457\u964d\u4f4e42% \uff08P < 0.01\uff09\u3002\u540c\u6837\u5730\uff0c\u76ae\u8d28\u533a\u51cf\u5c1134%\uff08P < 0.01\uff09\uff0c\u6d77\u9a6c\u4f53\u51cf\u5c1132%\uff08P < 0.05\uff09\u3002\u6cbb\u7597\u7ec4\u4e0e\u5bf9\u7167\u7ec4\u5728\u6dc0\u7c89\u6837\u86cb\u767d\u5927\u5c0f\u65b9\u9762\u65e0\u5dee\u5f02\u3002\u5728\u5c0f\u80f6\u8d28\u7ec6\u80de\u6fc0\u6d3b\u65b9\u9762\uff0c\u6cbb\u7597\u7ec4\u5c0f\u9f20\u7684\u76ae\u8d28Iba-1\u9633\u6027\u533a\u57df\u6bd4\u5bf9\u7167\u7ec4\u663e\u8457\u964d\u4f4e51%\uff08P < 0.001\uff09\uff0c\u6d77\u9a6c\u533a\u51cf\u5c1137%\uff0c\u4f46\u4e0a\u8ff0\u6570\u636e\u6ca1\u6709\u8fbe\u5230\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u5728\u6cbb\u7597\u5f00\u59cb9\u5468\u540e\u5bf9\u5c0f\u9f20\u8fdb\u884c\u7a7a\u95f4\u8bb0\u5fc6\u6d4b\u8bd5\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u6cbb\u7597\u7ec4\u52a8\u7269\u884c\u8d70\u7684\u8ddd\u79bb\u660e\u663e\u8f83\u77ed\uff0c\u4e14\u57286\u5468\u7684\u6cbb\u7597\u540e\u7684\u5e73\u5747\u901f\u5ea6\u66f4\u6162\u3002\u6700\u540e\uff0c\u6d77\u9a6c\u7a81\u89e6\u7d20\u514d\u75ab\u67d3\u8272\u663e\u793a\uff0c\u878d\u5408\u86cb\u767d\u5904\u7406\u540e\u6d77\u9a6c\u7a81\u89e6\u635f\u5931\u66f4\u5c11\uff0c\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u9f7f\u72b6\u56de\u589e\u52a037%\uff0cCA3\u533a\u589e\u52a035%\uff0c\u6d77\u9a6c\u603b\u533a\u57df\u589e\u52a028%\uff08P < 0.05\uff09\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f7f\u7528\u8fd9\u79cd\u65b0\u878d\u5408\u86cb\u767d\u8fdb\u884c\u6162\u6027\u6cbb\u7597\uff0c\u53ef\u4ee5\u7f13\u89e3\u4e0eAD\u76f8\u5173\u7684\u751f\u7269\u5b66\u6307\u5f81\uff0c\u6539\u5584\u8bb0\u5fc6\uff0c\u8bc1\u660e\u4e86\u8fd9\u79cd\u6cbb\u7597\u65b9\u6cd5\u7684\u4fdd\u62a4\u4f5c\u7528\u3002\uff08Chang, R. et al. Alzheimer’s AssocIntConf (AAIC) (July 22-26, Chicago) 2018, Abst P3-057\uff09\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                8<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u547c\u5438\u7cfb\u7edf\u75be\u75c5<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e747\u670811\u65e5\uff0c\u845b\u5170\u7d20\u53f2\u514b\u53d1\u73b0\u65b0\u7684NFE2L2\u6fc0\u52a8\u5242<\/p>\n<\/section>\n

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                                <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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                                \u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\u8fd1\u65e5\u62a5\u9053\u4e86\u4e00\u7c7b\u6838\u56e0\u5b50E2\u76f8\u5173\u56e0\u5b502\uff08NFE2L2\uff09\u6fc0\u6d3b\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\uff08COPD\uff09\u548c\u5fc3\u529b\u8870\u7aed\u7b49\u75be\u75c5\u7684\u6cbb\u7597\u3002\u5728NQO1\u9176\u7684\u7ec6\u80deMTT\u68c0\u6d4b\u4e2d\uff0c\u4ee3\u8868\u5316\u5408\u7269I\u3001II\u548cIII\u5728\u4eba\u80ba\u4e0a\u76ae\u7ec6\u80deBEAS-2B\u4e2d\u5bf9NFE2L2\u6fc0\u52a8\u4f5c\u7528\u7684EC50\u5206\u522b\u4e3a1-10 nM\u3001< 1 nM\u548c< 1 nM\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018109647\uff0cWO 2018109648\u548cWO 2018109643\uff09\u3002<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u4e0a\u56fe\u4e3aWO 2018109647\u4e2d\u4ee3\u8868\u5316\u5408\u7269I\u7684\u7ed3\u6784<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u4e0a\u56fe\u4e3aWO 2018109648\u4e2d\u4ee3\u8868\u5316\u5408\u7269II\u7684\u7ed3\u6784<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u4e0a\u56fe\u4e3aWO 2018109643\u4e2d\u4ee3\u8868\u5316\u5408\u7269III\u7684\u7ed3\u6784<\/span><\/p>\n


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                                <\/section>\n<\/section>\n<\/section>\n
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                                \u79d1\u777f\u552f\u5b89\u5bf9\u672c\u6587\u7684\u5168\u90e8\u5185\u5bb9\u4ee5\u53ca\u53ef\u80fd\u9644\u5e26\u7684\u5168\u90e8\u8d44\u6599\u62e5\u6709\u5168\u90e8\u77e5\u8bc6\u4ea7\u6743\uff0c\u5e76\u53d7\u6cd5\u5f8b\u4fdd\u62a4\u3002\u7f51\u7edc\u8f6c\u8f7d\u3001\u7f16\u8bd1\u53ca\u5176\u4ed6\u5546\u4e1a\u4f7f\u7528\u8bf7\u8054\u7cfb\u5e02\u573a\u90e8\uff1ayili1@Clarivate.com<\/span><\/p>\n

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                                Clarivate Analytics \u836f\u7269\u65b0\u95fb<\/span><\/strong><\/p>\n


                                <\/p>\n

                                \u5468\u4e00\u81f3\u5468\u4e94\u52a8\u6001\u66f4\u65b0\u7684\u836f\u7269\u65b0\u95fb\u548cEMAIL\u8ddf\u8e2a\u63d0\u9192<\/span>
                                <\/p>\n


                                <\/span><\/p>\n

                                \u25a0 <\/span> \u6bcf\u5468\u4e00\u81f3\u4e94, Clarivate Analytics\u836f\u7269\u65b0\u95fb\uff08Clarivate Analytics BioWorld Science\uff09\u7cbe\u9009\u6700\u65b0\u3001\u6700\u91cd\u8981\u7684\u836f\u7269\u7814\u53d1\u65b0\u95fb\u5728\u7ebf\u53d1\u5e03\uff0c\u5e76\u4ee5\u7b80\u660e\u627c\u8981\u7684\u683c\u5f0f\u53d1\u9001\u63d0\u9192\u90ae\u4ef6\u81f3\u60a8\u7684\u90ae\u7bb1\uff0c\u5e2e\u52a9\u60a8\u5feb\u901f\u9501\u5b9a\u91cd\u8981\u7684\u65b0\u95fb\u4e8b\u4ef6\u3002<\/span><\/p>\n

                                \u25a0<\/span>  \u60a8\u53ef\u4ee5\u5728\u7ebf\u68c0\u7d22\u6211\u4eec\u6240\u6709\u7684\u65b0\u95fb\u8d44\u6e90\uff0c\u5e76\u8bbe\u5b9a\u68c0\u7d22\u6761\u4ef6\uff08\u9650\u5b9a\u65b0\u95fb\u53d1\u751f\u7684\u65f6\u95f4\u3001\u836f\u540d\u3001\u4e13\u5229\u53f7\u3001\u516c\u53f8\u3001\u5927\u5b66\u3001\u673a\u6784\u3001\u6cbb\u7597\u7c7b\u522b\/\u5206\u7ec4\u3001\u5316\u5408\u7269\u7c7b\u578b\u3001\u4fe1\u606f\u6e90\uff09\u627e\u5230\u4e0e\u60a8\u7814\u7a76\u76f8\u5173\u7684\u5185\u5bb9\u3002\u836f\u7269\u65b0\u95fb\uff08BioWorld Science\uff09\u5185\u5bb9\u53ef\u56de\u6eaf\u81f31996\u5e74\uff0c\u5e76\u53ef\u67e5\u770b\u5316\u5b66\u7ed3\u6784\u5f0f\u3002<\/span><\/p>\n


                                <\/p>\n


                                <\/p>\n

                                \u836f\u7269\u65b0\u95fb\uff08BioWorld Science\uff09\u63d0\u4f9b\u5982\u4e0b\u5185\u5bb9\uff1a<\/span><\/p>\n

                                \u25a0<\/span>  \u4ece\u6d77\u91cf\u4fe1\u606f\u6e90\u4e2d\u603b\u7ed3\u51fa\u7684\u6458\u8981\u62a5\u544a\u3002<\/span><\/p>\n

                                \u25a0<\/span>  \u5728\u5168\u7403\u91cd\u8981\u4f1a\u8bae\u4e2d\u62ab\u9732\u7684\u65b0\u95fb\u4fe1\u606f\u3002<\/span><\/p>\n

                                \u25a0 <\/span> \u6bcf\u5468\u66f4\u65b0\u7684\u90ae\u4ef6\u63d0\u9192\u670d\u52a1\uff0c\u4ee5\u8868\u683c\u7684\u5f62\u5f0f\u544a\u77e5\u60a8\u8fdb\u5165\u4e34\u5e8a\u524d\u5f00\u53d1\u6700\u6709\u524d\u666f\u7684\u5316\u5408\u7269\u3001lead compounds\u548c\u6700\u65b0\u7684\u4f5c\u7528\u673a\u5236\u3002<\/span><\/p>\n

                                \u25a0<\/span>  \u6bcf\u5468\u66f4\u65b0\u7684\u90ae\u4ef6\u63d0\u9192\u670d\u52a1\uff0c\u544a\u77e5\u60a8\u5728\u7814\u836f\u7269\u7814\u53d1\u72b6\u6001\u7684\u53d8\u66f4\u3002<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

                                <\/span><\/p>\n


                                <\/p>\n<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

                                \u4e2d\u6587\u7ffb\u8bd1\uff1a\u963f\u6817\u535a\u58eb Drug Dally News \u5df2\u6b63\u5f0f\u66f4\u540d\u4e3aBioWorld Science \u5feb\u901f\u5bfc\u89c8 \u80bf […]<\/p>\n","protected":false},"author":1,"featured_media":42712,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/42711"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=42711"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/42711\/revisions"}],"predecessor-version":[{"id":42733,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/42711\/revisions\/42733"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/42712"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=42711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=42711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=42711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}