{"id":43279,"date":"2018-09-08T01:00:00","date_gmt":"2018-09-17T07:13:12","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e6%b5%85%e8%b0%88%ef%bc%9a%e6%96%b0%e8%8d%af%e5%bc%80%e5%8f%91%e8%bf%87%e7%a8%8b%e4%b8%ad%e4%b8%8d%e5%8f%af%e4%b8%8d%e7%9f%a5%e7%9a%84adr%e9%97%ae%e9%a2%98\/"},"modified":"2018-09-17T15:13:16","modified_gmt":"2018-09-17T07:13:16","slug":"%e6%b5%85%e8%b0%88%ef%bc%9a%e6%96%b0%e8%8d%af%e5%bc%80%e5%8f%91%e8%bf%87%e7%a8%8b%e4%b8%ad%e4%b8%8d%e5%8f%af%e4%b8%8d%e7%9f%a5%e7%9a%84adr%e9%97%ae%e9%a2%98","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/43279\/","title":{"rendered":"\u6d45\u8c08\uff1a\u65b0\u836f\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u4e0d\u53ef\u4e0d\u77e5\u7684ADR\u95ee\u9898"},"content":{"rendered":"
\n

\"\u6d45\u8c08\uff1a\u65b0\u836f\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u4e0d\u53ef\u4e0d\u77e5\u7684ADR\u95ee\u9898\"<\/p>\n

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1<\/span>\u635f\u5931\u60e8\u91cd\u2014\u2014\u836f\u54c1\u56e0ADR\u9000\u5e02\uff0c\u4eba\u4f53\u56e0ADR\u51c4\u82e6<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u836f\u7269\u4e0d\u826f\u53cd\u5e94(ADR)\uff0c\u7edd\u5bf9\u662f\u5236\u836f\u516c\u53f8\u5728\u65b0\u836f\u5f00\u53d1\u8fc7\u7a0b\u6240\u5fc5\u987b\u9762\u4e34\u7684\u4e00\u5927\u6311\u6218\uff0c\u5176\u4e3b\u8981\u4f53\u73b0\u5728\u5bf9\u4e0a\u5e02\u836f\u54c1\u6216\u65b0\u836f\u672a\u77e5\u7684\u4e0d\u826f\u53cd\u5e94\u8fdb\u884c\u6316\u6398\u53ca\u9884\u6d4b\u3002\u65b0\u836f\u7814\u53d1\u901a\u5e38\u9700\u8981\u8017\u8d39\uff1e10\u4ebf\u7f8e\u5143\uff0c\u5e76\u4e14\u9700\u8981\u5927\u7ea6\u8d85\u8fc710\u5e74\u5de6\u53f3\u7684\u6301\u7eed\u6295\u8d44\uff0c\u4ee5\u53ca\u9488\u5bf9\u540c\u4e00\u836f\u7269\u8fdb\u884c\u7279\u5b9a\u53d7\u4f17\u7fa4\u4f53\u7684\u62bd\u6837\u7814\u7a76\u3002\u5728\u65b0\u836f\u7814\u53d1\u8fc7\u7a0b\u4e2d\uff0c\u672a\u88ab\u53d1\u73b0\u7684\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u901a\u5e38\u4f1a\u9020\u6210\u4e34\u5e8a\u8bd5\u9a8c\u5728\u201c\u6700\u540e\u4e00\u516c\u91cc\u201d\u9636\u6bb5\u800c\u5931\u8d25\u3002<\/span><\/p>\n

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\u5728\u82f1\u56fd\uff0c1992~2002\u5e74\u671f\u95f4\uff0c\u5df1\u670912\u79cd\u65b0\u836f\u5728\u4e0a\u5e02\u540e\u88ab\u53d1\u73b0\u5728\u4e34\u5e8a\u9636\u6bb5\u672a\u88ab\u68c0\u6d4b\u51fa\u7684\u4e0d\u826f\u53cd\u5e94\u800c\u88ab\u5e9f\u5f03\u4f7f\u7528\uff1b\u5728\u7f8e\u56fd\uff0c1976\u5e74~2005\u5e74\uff0c\u4e25\u91cd\u7684ADR\u5bfc\u81f428\u79cd\u836f\u7269\u9000\u51fa\u7f8e\u56fd\u5e02\u573a\uff0c\u5b89\u5168\u6027\u65b9\u9762\u7684\u539f\u56e0\u4e3b\u8981\u96c6\u4e2d\u5728\u809d\u6bd2\u6027\u3001\u80be\u6bd2\u6027\u3001\u5fc3\u810f\u6bd2\u6027\u3001\u6a2a\u7eb9\u808c\u6eb6\u89e3\u7b49\u3002\u5982Vioxx\uff0c1999\u5e74\u88abFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u5168\u7403\u4f7f\u7528\u8303\u56f4\u6781\u5e7f\uff0c5\u5e74\u540e\uff0c\u7531\u4e8e\u5fc3\u810f\u6bd2\u95ee\u9898\u88ab\u8981\u6c42\u64a4\u5e02\uff0c\u8fd9\u4e2a\u54c1\u79cd\u4e5f\u662f\u6709\u53f2\u4ee5\u6765\u4f7f\u7528\u6700\u4e3a\u5e7f\u6cdb\u5e76\u8981\u6c42\u64a4\u5e02\u7684\u836f\u7269\u4e4b\u4e00\u3002<\/span><\/p>\n

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\u4e00\u7bc7\u8bba\u6587\u4e2d\u6307\u51fa\uff0c\u81ea1975\u5e74\u81f31999\u5e74\u671f\u95f4\u901a\u8fc7\u4e34\u5e8a\u5b9e\u9a8c\u7684548\u79cd\u65b0\u836f\u4e2d\uff0c\u5927\u7ea6\u670916\u79cd\u836f\u7269\u56e0\u5728\u5927\u89c4\u6a21\u4f7f\u7528\u540e\u5bfc\u81f4\u4e25\u91cd\u7684\u3001\u672a\u5728\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u53d1\u73b0\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u800c\u88ab\u5e9f\u5f03\u4f7f\u7528\u3002\u540c\u65f6\uff0c\u53e6\u4e00\u7bc7\u8bba\u6587\u4e2d\u4e5f\u6307\u51fa\uff0c\u5728\u65b0\u836f\u6295\u5165\u5e02\u573a\u8fdb\u884c\u5927\u89c4\u6a21\u4f7f\u7528\u524d\uff0c\u5982\u679c\u80fd\u591f\u5c06\u65b0\u836f\u6f5c\u5728\u4e0d\u826f\u53cd\u5e94\u7684\u76d1\u6d4b\u6210\u529f\u7387\u4ece1\/5\u63d0\u5347\u81f31\/3\uff0c\u5219\u53ef\u4ee5\u4e3a\u5236\u836f\u516c\u53f8\u5728\u65b0\u836f\u7814\u53d1\u9636\u6bb5\u8282\u7701\u5927\u7ea62.21\u4ebf\u7f8e\u5143\uff0c\u4ee5\u53ca\u5728\u65b0\u836f\u4e0a\u5e02\u540e\u7684\u76d1\u6d4b\u8fc7\u7a0b\u4e2d\u8282\u7701\u5927\u7ea61. 29\u4ebf\u7f8e\u5143\u3002\u56e0\u6b64\uff0c\u5bf9\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u9884\u6d4b\u5728\u65b0\u836f\u7814\u53d1\u548c\u540e\u671f\u7684\u836f\u7269\u76d1\u6d4b\u8fc7\u7a0b\u4e2d\u5177\u6709\u91cd\u8981\u7684\u4f5c\u7528\u548c\u7814\u7a76\u4ef7\u503c\u3002<\/span><\/p>\n

<\/span><\/p>\n

\"\u6d45\u8c08\uff1a\u65b0\u836f\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u4e0d\u53ef\u4e0d\u77e5\u7684ADR\u95ee\u9898\"<\/p>\n

\u56fe1 \u5c3d\u53ef\u80fd\u63d0\u524d\u4e86\u89e3\u836f\u54c1ADR<\/span>
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2<\/span>\u65f6\u523b\u5de5\u4f5c\u7740\u7684ADR\u76d1\u6d4b\u6570\u636e\u5e93<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u968f\u7740\u5404\u79cd\u836f\u5bb3\u4e8b\u4ef6\u5927\u89c4\u6a21\u7206\u53d1\uff0c\u4ee5\u53ca\u4fe1\u606f\u5316\u53d1\u5c55\u4e4b\u8fc5\u901f\uff0c\u5168\u7403\u8bb8\u591a\u56fd\u5bb6\u5730\u533a\u5236\u4f5c\u4e86\u81ea\u53d1\u5448\u62a5\u7cfb\u7edf\u6570\u636e\u5e93\u3002\u76ee\u524d\uff0c\u901a\u7528\u7684\u81ea\u53d1\u5448\u62a5\u7cfb\u7edf\u6570\u636e\u5e93\u5305\u62ec\uff1a\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5efa\u7acb\u5e76\u516c\u5f00\u7684\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6\u5448\u62a5\u7cfb\u7edf(FDA Adverse Event Reporting System, FAERS )\uff0c\u4e16\u754c\u536b\u751f\u7ec4\u7ec7(World Health Organization, WHO)\u5efa\u7acb\u7684\u56fd\u9645\u836f\u7269\u5b89\u5168\u76d1\u89c6\u7cfb\u7edf\uff0c\u4ee5\u53ca\u82f1\u56fd\u836f\u54c1\u4e0e\u4fdd\u5065\u54c1\u7ba1\u7406\u5c40(Medicines andHealthcare Products Regulatory Agency,MHRA)\u5efa\u7acb\u7684\u9ec4\u5361\u4f53\u7cfb(YellowCard Scheme)\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5168\u4e16\u754c\u7684\u4e13\u4e1a\u673a\u6784\u6216\u666e\u901a\u75c5\u4eba\u53ef\u4ee5\u901a\u8fc7\u5c06\u7591\u4f3c\u7531\u836f\u7269\u5f15\u8d77\u7684\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6\u5448\u62a5SRS\uff0c\u6784\u5efa\u6d77\u91cf\u7684\u3001\u4e30\u5bcc\u7684\u3001\u8de8\u5730\u57df\u7684\u4e0d\u826f\u53cd\u5e94\u6570\u636e\u5e93\uff0c\u5e76\u7531\u4e13\u4e1a\u7814\u7a76\u4eba\u5458\u5bf9\u6570\u636e\u8fdb\u884c\u5904\u7406\u548c\u6784\u5efa\u6570\u636e\u96c6\u3002\u8fd9\u5bf9\u4e8e\u7814\u7a76\u548c\u53d1\u73b0\u4e0d\u826f\u53cd\u5e94\uff0c\u6709\u7740\u91cd\u8981\u7684\u4ef7\u503c\u3002\u5728\u4e0a\u4e16\u7eaa90\u5e74\u4ee3\uff0c\u7814\u7a76\u4eba\u5458\u6b63\u662f\u501f\u52a9SRS\u6570\u636e\u5e93\u53d1\u73b0\u4e86\u66f2\u683c\u5217\u916e\u3001\u66f2\u9a6c\u591a\uff0c\u4ee5\u53ca\u66ff\u9a6c\u6c99\u661f\u4e4b\u95f4\u4f1a\u4ea7\u751f\u836f\u7269\u4e0d\u826f\u53cd\u5e94~\u809d\u635f\u5bb3\u3001\u766b\u75eb\u3001\u518d\u751f\u969c\u788d\u6027\u8d2b\u8840\u3001\u4ee5\u53ca\u8840\u6db2\u75c5\u3002<\/span><\/p>\n


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\"\u6d45\u8c08\uff1a\u65b0\u836f\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u4e0d\u53ef\u4e0d\u77e5\u7684ADR\u95ee\u9898\"<\/p>\n

\u56fe2 \u7f8e\u56fdFDA\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6\u5448\u62a5\u7cfb\u7edf<\/span><\/p>\n

(\u6765\u6e90\u4e8e\uff1ahttp:\/\/www.nber.org\/data\/fda-adverse-event-reporting-system-faers-data.html)<\/span><\/p>\n


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3<\/span>ADR\u2014\u2014\u6db5\u76d6\u5185\u5bb9\u4e30\u5bcc\uff0c\u4f46\u9700\u8981\u4e0d\u65ad\u6df1\u5165\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u6d45\u8c08\uff1a\u65b0\u836f\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u4e0d\u53ef\u4e0d\u77e5\u7684ADR\u95ee\u9898\"<\/p>\n


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4<\/span>ADR\u2014\u2014\u7c7b\u522b\u7ec6\u5206\u8be6\u7ec6\uff0c\u9700\u8981\u9776\u5411\u89e3\u51b3\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n

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 <\/span><\/p>\n

\u2606~B\u578b\u4e0d\u826f\u53cd\u5e94(\u8d28\u53d8\u578b\u5f02\u5e38)<\/span><\/strong><\/span><\/p>\n

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<\/span><\/p>\n

\"\u6d45\u8c08\uff1a\u65b0\u836f\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u4e0d\u53ef\u4e0d\u77e5\u7684ADR\u95ee\u9898\"<\/p>\n

\u56fe3 ADR\u63096\u7c7b\u5212\u5206\u60c5\u51b5<\/span><\/p>\n


<\/span><\/p>\n

\n
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5<\/span>ADR\u4ea7\u751f\u7684\u51e0\u79cd\u5e38\u89c1\u56e0\u7d20\u4e3e\u4f8b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/span><\/p>\n

\u2606~\u5242\u91cf\u4e0e\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u5173\u7cfb<\/span><\/strong><\/span><\/p>\n

20\u4e16\u7eaa 80 \u5e74\u4ee3\uff0c\u7531\u4e8e\u5e86\u5927\u9709\u7d20\u7684\u5e7f\u6cdb\u4f7f\u7528\uff0c\u5f88\u591a\u5c0f\u5b69\u51fa\u73b0\u5148\u5929\u6027\u8033\u804b\u3002\u4e3b\u8981\u539f\u56e0\u5728\u6bcd\u4eb2\u6000\u5b55\u7684\u65f6\u5019\u4f7f\u7528\u4e86\u8fc7\u91cf\u7684\u5e86\u5927\u9709\u7d20\u6216\u4e0d\u5408\u7406\u5730\u4f7f\u7528\u5f15\u8d77\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u2606~\u836f\u7269\u4f9d\u8d56\u6027\u4e0e\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u5173\u7cfb<\/span><\/strong><\/span><\/p>\n

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 <\/span><\/p>\n

\u2606~\u4e2a\u4f53\u56e0\u7d20\u4e0e\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u5173\u7cfb<\/span><\/strong><\/span><\/p>\n

\u836f\u54c1\u5f02\u5e38\u5bfc\u81f4\u836f\u7269\u4e0d\u826f\u53cd\u5e94\uff0c\u4e34\u5e8a\u8868\u73b0\u4e3a\u5168\u8eab\u6027\u53cd\u5e94\u548c\u76ae\u80a4\u53cd\u5e94\u4e24\u5927\u7c7b\u3002\u800c\u60a3\u8005\u5f02\u5e38\uff0c\u6307\u540c\u6837\u7684\u5242\u91cf\u8868\u73b0\u51fa\u6781\u654f\u611f\u6216\u4e0d\u654f\u611f\u7684\u53cd\u5e94\uff0c\u591a\u4e0e\u9057\u4f20(\u5982\u7279\u6b8a\u809d\u4ee3\u8c22\u9176\u7684\u6709\u65e0)\u3001\u514d\u75ab(\u8fd1\u5e74\u6765\u7814\u7a76\u8f83\u70ed)\u7b49\u56e0\u7d20\u6709\u5173\u3002\u867d\u7136\u8fd9\u79cd\u7c7b\u578b\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4e0d\u9ad8\uff0c\u4f46\u75c5\u6b7b\u7387\u8f83\u9ad8\uff0c\u4e34\u5e8a\u533b\u5e08\u5e94\u7279\u522b\u5173\u6ce8\u8fd9\u79cd\u4e2a\u4f53\u5dee\u5f02\u8005\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u2606~\u6027\u522b\u3001\u5e74\u9f84\u4e0e\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u5173\u7cfb<\/span><\/strong><\/span><\/p>\n

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 <\/span><\/p>\n

\u2606~\u4e0d\u540c\u7ed9\u836f\u9014\u5f84\u4e0e\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u5173\u7cfb<\/span><\/strong><\/span><\/p>\n

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<\/p>\n

\n
\n
\n
\n

6<\/span>\u65e5\u5e38\u5982\u4f55\u7814\u7a76ADR\u76f8\u5173\u95ee\u9898<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/span><\/p>\n

\u9996\u5148\uff0c\u5728\u65b0\u836f\u7814\u53d1\u7684\u4e34\u5e8a\u9636\u6bb5\uff0c\u901a\u8fc7\u5206\u6790\u836f\u7269\u7684\u5316\u5b66\u6210\u5206\u3001\u52a8\u7269\u5b9e\u9a8c\u3001\u836f\u7269\u5242\u91cf\u8c03\u914d\u3001\u836f\u7269\u4ee3\u8c22\u4ee5\u53ca\u836f\u7269\u52a8\u529b\u5b66\u7b49\u65b9\u6cd5\u5206\u6790\u6f5c\u5728\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5176\u6b21\uff0c\u901a\u8fc7\u57fa\u4e8e\u81ea\u53d1\u5448\u62a5\u7cfb\u7edf\u6570\u636e\u5e93\u5bf9\u5df1\u6709\u7684(\u836f\u7269~\u4e0d\u826f\u53cd\u5e94)\u5173\u8054\u5173\u7cfb\u6570\u636e\u8fdb\u884c\u5206\u6790\uff0c\u4ece\u800c\u9884\u6d4b\u5355\u4e2a\u836f\u7269\u6f5c\u5728\u7684\u4e0d\u826f\u53cd\u5e94;\u540c\u6837\u57fa\u4e8e\u81ea\u53d1\u5448\u62a5\u7cfb\u7edf\u6570\u636e\u5e93\uff0c\u5206\u6790\u75c5\u4f8b\u4e2d\u836f\u7269\u7ec4\u5408\u4e0e\u4e0d\u826f\u53cd\u5e94\u7684\u5173\u8054\u5173\u7cfb\uff0c\u4ece\u800c\u5bf9\u75c5\u4eba\u7684\u65b0\u75c7\u72b6\u4ee5\u53ca\u6240\u670d\u7528\u7684\u836f\u7269\u7ec4\u5408\uff0c\u9884\u6d4b\u6f5c\u5728\u7684\u836f\u7269\u4e0d\u826f\u53cd\u5e94;<\/span><\/p>\n

 <\/span><\/p>\n

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<\/p>\n

\n
\n
\n
\n

7<\/span>\u5c0f\u7ed3&\u5c0f\u611f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/span><\/p>\n

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<\/p>\n

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