{"id":43490,"date":"2018-09-04T01:00:00","date_gmt":"2018-09-17T07:15:20","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/2018%e5%b9%b47%e6%9c%88%e4%b8%ad%e5%9b%bd1%e7%b1%bb%e6%96%b0%e8%8d%af%e4%b8%b4%e5%ba%8a%e5%8a%a8%e6%80%81%ef%bc%88%e4%ba%8c%ef%bc%89\/"},"modified":"2018-09-17T15:15:26","modified_gmt":"2018-09-17T07:15:26","slug":"2018%e5%b9%b47%e6%9c%88%e4%b8%ad%e5%9b%bd1%e7%b1%bb%e6%96%b0%e8%8d%af%e4%b8%b4%e5%ba%8a%e5%8a%a8%e6%80%81%ef%bc%88%e4%ba%8c%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/43490\/","title":{"rendered":"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537168521.jpeg\" alt=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\" title=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"margin-top: 15px;margin-bottom: 15px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"margin-top: -3px;margin-bottom: -3px;padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(0, 0, 0);color: rgb(62, 62, 62);letter-spacing: 0px;line-height: 1.75;transform: rotate(0deg);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-family: Helvetica, Arial, sans-serif;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">1\u7c7b\u751f\u7269\u836f\u6279\u51c6\u4e34\u5e8a\u6982\u51b5<\/span><\/strong><\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(255, 255, 255);background-color: rgb(30, 155, 232);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">2018\u5e747\u6708\uff0c\u5171\u670910\u4e2a\u4e2d\u56fd1\u7c7b\u751f\u7269\u836f\u83b7\u5f97\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u5373\u5c06\u5f00\u59cb\u4e34\u5e8a\u4e00\u671f\u8bd5\u9a8c\uff0c\u5176\u4e2d4\u4e2a\u662f\u7279\u6b8a\u5ba1\u6279\u54c1\u79cd\u3002\u6297\u764c\u836f\u7269\u4e00\u5171\u67098\u4e2a\uff0c\u76ae\u80a4\u75c5\u836f\u7269\u548c\u6297\u611f\u67d3\u836f\u7269\u54041\u4e2a\uff0c\u5177\u4f53\u4fe1\u606f\u5982\u4e0b\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;widows: 1;line-height: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537168521.jpg\" alt=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\" title=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: inline-block;word-wrap: break-word !important;\">\n<p style=\"margin-top: 8px;padding-right: 10px;max-width: 100%;min-height: 32px;font-weight: bold;font-size: 16px;line-height: 28px;color: rgb(68, 120, 242);border-bottom: 1.5px solid rgb(68, 120, 242);border-top-color: rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\"  placeholder=\"1\" title=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;background-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\">1<\/span><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u91cd\u7ec4\u4eba\u6e90\u5316\u6297<\/span>PD-1<span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u5c71\u4e1c\u65b0\u65f6\u4ee3\u836f\u4e1a\uff09<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5c71\u4e1c\u65b0\u65f6\u4ee3\u836f\u4e1a\uff08\u9c81\u5357\u836f\u4e1a\u96c6\u56e2\u7684\u6210\u5458\u516c\u53f8\uff09\u5f00\u53d1\u7684\u91cd\u7ec4\u4eba\u6e90\u5316\u6297PD-1\u5355\u6297\u53ef\u7528\u4e8e\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u30022014\u5e749\u6708\u4e0a\u5e02\u7684\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f531 (PD-1)\u963b\u65ad\u5242Keytruda<\/span><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span lang=\"EN-US\" style=\"max-width: 100%;font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">\u00ae<\/span><\/sup><\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6210\u4e3a\u7f8e\u56fd\u9996\u4e2a\u201c\u5e7f\u8c31\u6297\u764c\u836f\u201d\uff0c\u5728\u591a\u79cd\u764c\u75c7\u91cc\u9762\u90fd\u5f97\u5230\u4e86\u5e94\u7528\uff0c\u53ef\u4ee5\u5f88\u597d\u7684\u63a7\u5236\u764c\u75c7\u7684\u8fdb\u7a0b\u3002\u8fd9\u53ef\u4ee5\u8bf4\u662f\u80bf\u7624\u6cbb\u7597\u53f2\u65e0\u524d\u4f8b\u7684\u5f00\u521b\u6027\u7a81\u7834\u3002\u76ee\u524d\u9776\u5411PD-1\u7684\u4e2d\u56fd1\u7c7b\u751f\u7269\u836f\u670915\u4e2a\uff0c\u5177\u4f53\u60c5\u51b5\u5982\u4e0b\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537168522.jpg\" alt=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\" title=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: inline-block;word-wrap: break-word !important;\">\n<p style=\"margin-top: 8px;padding-right: 10px;max-width: 100%;min-height: 32px;font-weight: bold;font-size: 16px;line-height: 28px;color: rgb(68, 120, 242);border-bottom: 1.5px solid rgb(68, 120, 242);border-top-color: rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\"  placeholder=\"1\" title=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;background-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\">2<\/span><strong style=\"max-width: 100%;font-size: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">CS-1003<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">CS-1003\u662f\u57fa\u77f3\u836f\u4e1a\u901a\u8fc7\u6742\u4ea4\u7624\u6280\u672f\u5e73\u53f0\u5f00\u53d1\u7684\u4e00\u79cd\u7684\u4eba\u6e90\u5316IgG4\u578b\u5355\u514b\u9686\u6297\u4f53\uff0c\u9776\u5411\u4e8e\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f531 (PD-1)\uff0c\u6b63\u5728\u8fdb\u884c\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u4e34\u5e8a\u4e00\u671f\u8bd5\u9a8c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u76ee\u524d\uff0c\u5168\u7403\u8303\u56f4\u5171\u6709\u4e24\u6b3e\u83b7\u6279\u7684 IgG4 \u578b PD-1\u5355\u6297\uff0c\u5206\u522b\u662f\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684Opdivo<\/span><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span lang=\"EN-US\" style=\"max-width: 100%;font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">\u00ae<\/span><\/sup><\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp; (nivolumab)\u548c\u9ed8\u6c99\u4e1c\u7684 Keytruda<\/span><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span lang=\"EN-US\" style=\"max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">\u00ae<\/span><\/sup><\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp; (pembrolizumab)\uff0c\u5176\u4e2dOpdivo<\/span><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span lang=\"EN-US\" style=\"max-width: 100%;font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">\u00ae<\/span><\/sup><\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;\u5df2\u4e8e2018\u5e746\u6708\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: inline-block;word-wrap: break-word !important;\">\n<p style=\"margin-top: 8px;padding-right: 10px;max-width: 100%;min-height: 32px;font-weight: bold;font-size: 16px;line-height: 28px;color: rgb(68, 120, 242);border-bottom: 1.5px solid rgb(68, 120, 242);border-top-color: rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\"  placeholder=\"1\" title=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;background-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\">3<\/span><strong class=\"\"  style=\"max-width: 100%;border-color: rgb(68, 120, 242);color: inherit;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-size: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6ce8\u5c04\u7528\u91cd\u7ec4\u4eba\u9f20\u5d4c\u5408\u6297CD30\u5355\u6297-MCC-DM1\u5076\u8054\u5242<\/span><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e0a\u6d77\u533b\u836f\u96c6\u56e2\u80a1\u4efd\u6709\u9650\u516c\u53f8\u5168\u8d44\u5b50\u516c\u53f8\u4e0a\u6d77\u4ea4\u8054\u836f\u7269\u7814\u53d1\u6709\u9650\u516c\u53f8\u4e0e\u4e0a\u6d77\u590d\u65e6\u5f20\u6c5f\u751f\u7269\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u8054\u5408\u5f00\u53d1\u7684\u6ce8\u5c04\u7528\u91cd\u7ec4\u4eba\u9f20\u5d4c\u5408\u6297CD30\u5355\u514b\u9686\u6297\u4f53-MCC-DM1\u5076\u8054\u5242\u3002\u8be5\u836f\u7269\u662f\u65b0\u578b\u4eba\u7528\u91cd\u7ec4\u5355\u514b\u9686\u6297\u4f53\u5236\u54c1\uff0c\u62df\u7528\u4e8e\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\u3001\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u548c\u76ae\u80a4T\u7ec6\u80de\u6dcb\u5df4\u7624\u3002\u6ce8\u5c04\u7528\u91cd\u7ec4\u4eba\u9f20\u5d4c\u5408\u6297 CD30 \u5355\u514b\u9686\u6297\u4f53-MCC-DM1 \u5076\u8054\u5242\u9776\u5411\u4e8eCD30\u548cTubulin\uff0c\u76ee\u524d\u9776\u5411CD30\u7684\u4e2d\u56fd1\u7c7b\u751f\u7269\u836f\u4ec5\u8be5\u836f\u7269\u4e00\u4e2a\uff0c\u800c\u4ee5Tubulin\u4e3a\u9776\u5411\u7684\u4e2d\u56fd1\u7c7b\u751f\u7269\u836f\u67093\u4e2a\uff0c\u5177\u4f53\u60c5\u51b5\u89c1\u4e0b\u8868\uff1a<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537168523.jpg\" alt=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\" title=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: inline-block;word-wrap: break-word !important;\">\n<p style=\"margin-top: 8px;padding-right: 10px;max-width: 100%;min-height: 32px;font-weight: bold;font-size: 16px;line-height: 28px;color: rgb(68, 120, 242);border-bottom: 1.5px solid rgb(68, 120, 242);border-top-color: rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\"  placeholder=\"1\" title=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;background-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\">4<\/span><strong class=\"\"  style=\"max-width: 100%;border-color: rgb(68, 120, 242);color: inherit;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-size: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u91cd\u7ec4\u4eba\u6e90\u5316\u6297PD-1\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u795e\u5dde\u7ec6\u80de\u5de5\u7a0b\uff09<\/span><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u795e\u5dde\u7ec6\u80de\u5de5\u7a0b\u5f00\u53d1\u7684\u91cd\u7ec4\u4eba\u6e90\u5316\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\u5df2\u5411\u4e2d\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(CFDA)\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u9012\u4ea4\u4e86\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c(IND)\u7533\u8bf7\uff08\u6cbb\u7597\u7528\u751f\u7269\u5236\u54c11\u7c7b\uff09\uff0c\u5e76\u4e8e2018\u5e743\u6708\u83b7\u5f97\u53d7\u7406\uff0c2018\u5e747\u6708\u83b7\u5f97\u4e34\u5e8a\u6279\u4ef6\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: inline-block;word-wrap: break-word !important;\">\n<p style=\"margin-top: 8px;padding-right: 10px;max-width: 100%;min-height: 32px;font-weight: bold;font-size: 16px;line-height: 28px;color: rgb(68, 120, 242);border-bottom: 1.5px solid rgb(68, 120, 242);border-top-color: rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\"  placeholder=\"1\" title=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;background-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\">5<\/span><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6297\u4eba<\/span>CD19T<span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7ec6\u80de\u6ce8\u5c04\u6db2<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e0a\u6d77\u6052\u6da6\u8fbe\u751f\u751f\u7269\u79d1\u6280\u5f00\u53d1\u7684CD19-CART\u662f\u4e00\u79cd\u5d4c\u5408\u6297\u539f\u53d7\u4f53(CAR) T\u7ec6\u80de\u7597\u6cd5\uff0c\u7531\u6297\u03b1CD19-TCR\u03b6-CD28\u548c\u03b1CD19-TCR\u03b6-CD137 CAR-T\u7ec6\u80de\u7b49\u91cf\u6df7\u5408\u800c\u6210\u3002\u8be5\u4ea7\u54c1\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u4e00\/\u4e8c\u671f\u7814\u7a76\u9636\u6bb5\uff0c\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3001\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u4ee5\u53ca\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002CAR-T\u662f\u4e00\u79cd\u9ad8\u6548\u3001\u5148\u8fdb\u7684\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff0c\u5df2\u5728\u767d\u8840\u75c5\u3001\u6dcb\u5df4\u7624\u3001\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u60ca\u4eba\u7684\u6548\u679c\u3002CAR-T\u6700\u6210\u529f\u7684\u6848\u4f8b\u662f\u4ee5CD19\u4e3a\u9776\u70b9\u9488\u5bf9B\u7ec6\u80de\u80bf\u7624\u7684\u4e00\u7cfb\u5217\u4e34\u5e8a\u8bd5\u9a8c\u3002\u76ee\u524d\u9776\u5411CD19\u7684\u4e2d\u56fd1\u7c7b\u751f\u7269\u836f\u670914\u4e2a\uff0c\u5177\u4f53\u60c5\u51b5\u5982\u4e0b\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537168524.jpg\" alt=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\" title=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: inline-block;word-wrap: break-word !important;\">\n<p style=\"margin-top: 8px;padding-right: 10px;max-width: 100%;min-height: 32px;font-weight: bold;font-size: 16px;line-height: 28px;color: rgb(68, 120, 242);border-bottom: 1.5px solid rgb(68, 120, 242);border-top-color: rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\"  placeholder=\"1\" title=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;background-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\">6<\/span><strong class=\"\"  style=\"max-width: 100%;border-color: rgb(68, 120, 242);color: inherit;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-size: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">BDB-001<\/span><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">BDB-001\u662f\u8212\u6cf0\u795e\u836f\u4e1a\u5f00\u53d1\u7684\u4e00\u79cd\u5355\u514b\u9686\u6297\u4f53\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u4e2d\u91cd\u5ea6\u5316\u8113\u6027\u6c57\u817a\u708e(HS)\u3002BDB-001\u9488\u5bf9HS\u81f4\u75c5\u673a\u7406\uff0c\u901a\u8fc7\u963b\u65adC5a\u53ef\u4ee5\u6709\u6548\u63a7\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u4ece\u800c\u63a7\u5236HS\u76f8\u5173\u75be\u75c5\u75c7\u72b6\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: inline-block;word-wrap: break-word !important;\">\n<p style=\"margin-top: 8px;padding-right: 10px;max-width: 100%;min-height: 32px;font-weight: bold;font-size: 16px;line-height: 28px;color: rgb(68, 120, 242);border-bottom: 1.5px solid rgb(68, 120, 242);border-top-color: rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\"  placeholder=\"1\" title=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;background-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\">7<\/span><strong class=\"\"  style=\"max-width: 100%;border-color: rgb(68, 120, 242);color: inherit;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong class=\"\"  style=\"max-width: 100%;color: inherit;border-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-size: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u91cd\u7ec4\u6297PD-L1\u5168\u4eba\u5355\u514b\u9686\u6297\u4f53\uff08\u4e0a\u6d77\u590d\u5b8f\u6c49\u9716\uff09<\/span><\/strong><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e0a\u6d77\u590d\u661f\u533b\u836f\uff08\u96c6\u56e2\uff09\u80a1\u4efd\u6709\u9650\u516c\u53f8\u63a7\u80a1\u5b50\u516c\u53f8\u4e0a\u6d77\u590d\u5b8f\u6c49\u9716\u751f\u7269\u6280\u672f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u53ca\u4e0a\u6d77\u590d\u5b8f\u6c49\u9716\u751f\u7269\u5236\u836f\u6709\u9650\u516c\u53f8\u5f00\u53d1\u7684\u91cd\u7ec4\u6297 PD-L1 \u5168\u4eba\u5355\u514b\u9686\u6297\u4f53\uff08\u7814\u53d1\u4ee3\u7801\uff1aHLX-20\uff09\u76ee\u524d\u5728\u6fb3\u5927\u5229\u4e9a\u5f00\u5c55\u4e34\u5e8a\u4e00\u671f\u8bd5\u9a8c\uff0c\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u3002\u76ee\u524d\uff0c\u5168\u7403\u4e0a\u5e02\u7684\u91cd\u7ec4\u6297 PD-L1 \u5168\u4eba\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u6709\u7f57\u6c0f\u7684Tecentriq<\/span><sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span lang=\"EN-US\" style=\"max-width: 100%;font-size: 9pt;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">\u00ae<\/span><\/sup><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;(Atezolizumab)\u3001\u9ed8\u514b\u548c\u8f89\u745e\u8054\u5408\u5f00\u53d1\u7684 Bavencio<\/span><sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span lang=\"EN-US\" style=\"max-width: 100%;font-size: 9pt;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">\u00ae<\/span><\/sup><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;(Avelumab)\u3001\u963f\u65af\u5229\u5eb7\u7684 Imfinzi<\/span><sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span lang=\"EN-US\" style=\"max-width: 100%;font-size: 9pt;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">\u00ae<\/span><\/sup><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;(Durvalumab)\uff1b\u4e2d\u56fd\u5883\u5185\uff08\u4e0d\u5305\u62ec\u6e2f\u6fb3\u53f0\u5730\u533a\uff09\u5c1a\u65e0\u5df2\u4e0a\u5e02\u7684\u91cd\u7ec4\u6297 PD-L1 \u5168\u4eba\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: inline-block;word-wrap: break-word !important;\">\n<p style=\"margin-top: 8px;padding-right: 10px;max-width: 100%;min-height: 32px;font-weight: bold;font-size: 16px;line-height: 28px;color: rgb(68, 120, 242);border-bottom: 1.5px solid rgb(68, 120, 242);border-top-color: rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\"  placeholder=\"1\" title=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;background-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\">8<\/span><strong class=\"\"  style=\"max-width: 100%;border-color: rgb(68, 120, 242);color: inherit;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong class=\"\"  style=\"max-width: 100%;color: inherit;border-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-size: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u91cd\u7ec4\u5168\u4eba\u6e90\u6297\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\u8d85\u5bb6\u65cf\u6210\u54584\uff08OX40\uff09\u5355\u514b\u9686\u6297\u4f53<\/span><\/strong><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4fe1\u8fbe\u751f\u7269\u5f00\u53d1\u7684\u91cd\u7ec4\u5168\u4eba\u6e90\u6297\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\u8d85\u5bb6\u65cf\u6210\u54584 (OX40)\u5355\u514b\u9686\u6297\u4f53\uff08\u7814\u53d1\u4ee3\u7801\uff1aIBI101\uff09\u662f\u76ee\u524d\u7b2c\u4e00\u4e2a\u5728\u4e2d\u56fd\u6279\u51c6\u7528\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u7684OX40\u5355\u514b\u9686\u6297\u4f53\u3002\u4f5c\u4e3a\u6297\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u91cd\u8981\u9776\u70b9\u4e4b\u4e00\uff0cOX40\u5355\u514b\u9686\u6297\u4f53\u7684\u7814\u53d1\u8fdb\u5c55\u4e00\u76f4\u5907\u53d7\u5173\u6ce8\u3002IBI101\u4f5c\u7528\u673a\u5236\u660e\u786e\uff0c\u80fd\u663e\u8457\u589e\u5f3a\u6548\u5e94T\u7ec6\u80de\u7684\u6d3b\u5316\uff0c\u5e76\u4ecb\u5bfc\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u6e05\u9664\uff0c\u4ece\u800c\u8d77\u5230\u6291\u5236\u80bf\u7624\u7ec6\u80de\u751f\u957f\u7684\u4f5c\u7528\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: inline-block;word-wrap: break-word !important;\">\n<p style=\"margin-top: 8px;padding-right: 10px;max-width: 100%;min-height: 32px;font-weight: bold;font-size: 16px;line-height: 28px;color: rgb(68, 120, 242);border-bottom: 1.5px solid rgb(68, 120, 242);border-top-color: rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\"  placeholder=\"1\" title=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;background-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\">9<\/span><strong class=\"\"  style=\"max-width: 100%;border-color: rgb(68, 120, 242);color: inherit;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong class=\"\"  style=\"max-width: 100%;color: inherit;border-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-size: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6ce8\u5c04\u7528\u57f9\u5e72\u6270\u7d20\u03b11b<\/span><\/strong><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537168525.jpg\" alt=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\" title=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: inline-block;word-wrap: break-word !important;\">\n<p style=\"margin-top: 8px;padding-right: 10px;max-width: 100%;min-height: 32px;font-weight: bold;font-size: 16px;line-height: 28px;color: rgb(68, 120, 242);border-bottom: 1.5px solid rgb(68, 120, 242);border-top-color: rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\"  placeholder=\"1\" title=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;background-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\">10<\/span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong class=\"\"  style=\"max-width: 100%;border-color: rgb(68, 120, 242);color: inherit;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong class=\"\"  style=\"max-width: 100%;color: inherit;border-color: rgb(68, 120, 242);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-size: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u91cd\u7ec4\u4eba<\/span><span style=\"max-width: 100%;font-family: Calibri, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">GM-CSF<\/span><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6eb6\u7624<\/span><span style=\"max-width: 100%;font-family: Calibri, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">II<\/span><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u578b\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2<\/span><span style=\"max-width: 100%;font-family: Calibri, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">OH2<\/span><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6ce8\u5c04\u6db2<\/span><span style=\"max-width: 100%;font-family: Calibri, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">Vero<\/span><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7ec6\u80de<\/span><\/strong><\/strong><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u91cd\u7ec4II\u578b\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\u6ce8\u5c04\u5236\u5242(OH2)\u5c5e\u4e8e\u80bf\u7624\u75ab\u82d7\u548c\u80bf\u7624\u57fa\u56e0\u6cbb\u75971\u7c7b\u65b0\u836f\uff0c\u6709\u5e7f\u8c31\u53ca\u5f3a\u6548\u4f4e\u6bd2\u7684\u6297\u80bf\u7624\u7597\u6548\u3002\u5176\u6cbb\u7597\u4e3b\u8981\u9488\u5bf9\u5b9e\u4f53\u7624\uff0c\u5305\u62ec\u80ba\u764c\u3001\u5934\u9888\u90e8\u80bf\u7624\u3001\u6dcb\u5df4\u7624\u3001\u809d\u764c\u3001\u9ed1\u8272\u7d20\u7624\u7b49\uff1b\u4e5f\u53ef\u4e0e\u4f20\u7edf\u653e\u5316\u7597\u8054\u5408\u5e94\u7528\uff0c\u63d0\u9ad8\u7597\u6548\u3001\u964d\u4f4e\u526f\u4f5c\u7528\uff1b\u540c\u65f6\u8fd8\u6709\u9884\u9632\u548c\u6cbb\u7597\u8f6c\u79fb\u7624\u7684\u6548\u679c\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;text-align: left;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"margin-top: 15px;margin-bottom: 15px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"margin-left: auto;max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(5, 115, 175);background-color: rgb(182, 228, 253);word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -3px;margin-bottom: -3px;padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(0, 0, 0);color: rgb(62, 62, 62);letter-spacing: 0px;line-height: 1.75;transform: rotate(0deg);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">1<\/span><span style=\"max-width: 100%;letter-spacing: 0px;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7c7b\u65b0\u836f<\/span><span style=\"max-width: 100%;letter-spacing: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">NDA<\/span><span style=\"max-width: 100%;letter-spacing: 0px;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7533\u8bf7\u6982\u51b5<\/span><\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(5, 115, 175);background-color: rgb(182, 228, 253);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">2018\u5e747\u6708\uff0cCDE\u5171\u627f\u529e\u4e861\u4e2a1\u7c7b\u65b0\u836f\u7684NDA\u7533\u8bf7\uff0c\u5177\u4f53\u4fe1\u606f\u5982\u4e0b\u8868\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537168526.jpg\" alt=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\" title=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u7532\u78fa\u9178\u6c1f\u9a6c\u66ff\u5c3c\u662f\u7531\u6c5f\u82cf\u8c6a\u68ee\u836f\u4e1a\u81ea\u4e3b\u7814\u53d1\u7684Bcr-abl\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5176\u662f\u5728\u5c3c\u6d1b\u66ff\u5c3c\u5206\u5b50\u7ed3\u6784\u4e0a\u8fdb\u884c\u4f18\u5316\u7684\u4e8c\u4ee3\u5206\u5b50\u9776\u5411\u836f\uff0c\u5bf9\u80f0\u817a\u3001\u809d\u80be\u529f\u80fd\u635f\u4f24\u660e\u663e\u4e0b\u964d\u3002\u7532\u78fa\u9178\u6c1f\u9a6c\u66ff\u5c3c\u660e\u663e\u6291\u5236\u7ec6\u80de\u5185Bcr-abl\u916a\u6c28\u9178\u6fc0\u9176\u7684\u6d3b\u6027\uff0c\u4f5c\u7528\u5f3a\u4e8e\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\uff1b\u7532\u78fa\u9178\u6c1f\u9a6c\u66ff\u5c3c\u5bf9Bcr-abl\u7684\u4e0b\u6e38\u4fe1\u53f7\u5982extracellualar-regulated kinase (ERK_\u4ee5\u53ca\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53(PDGFR)\u4e5f\u6709\u6291\u5236\u4f5c\u7528\uff1b\u4f46\u5bf9\u5176\u5b83\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6d3b\u6027\u5982\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(EGFR)\u3001\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f532 (VEGFR2\/KDR)\u5219\u6ca1\u6709\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\u3002<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"margin: 1em auto;max-width: 100%;box-sizing: border-box;border-width: initial;border-style: none;border-color: initial;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-left: 3px solid rgb(170, 166, 149);word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-left: 2px;padding: 0.6em;max-width: 100%;box-sizing: border-box;line-height: 1.5;text-align: left;border-left: 1px solid rgb(170, 166, 149);border-top-color: rgb(170, 166, 149);border-right-color: rgb(170, 166, 149);border-bottom-color: rgb(170, 166, 149);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">2006\u5e749\u6708\uff0c<\/span><\/strong><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">CDE\u627f\u529e\u7532\u78fa\u9178\u6c1f\u9a6c\u66ff\u5c3c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08\u5316\u836f1.1\u7c7b\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">2007\u5e749\u6708\uff0c<\/span><\/strong><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">CDE\u9881\u53d1\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">2011\u5e748\u6708\uff0c<\/span><\/strong><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6c5f\u82cf\u8c6a\u68ee\u542f\u52a8\u6cbb\u7597\u65b0\u8bca\u6210\u4eba\u6162\u6027\u671f\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u7684\u4e34\u5e8a\u4e8c\u671f\u8bd5\u9a8c(NCT01503502)\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">2014\u5e747\u6708\uff0c<\/span><\/strong><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6c5f\u82cf\u8c6a\u68ee\u542f\u52a8\u6cbb\u7597\u65b0\u8bca\u6210\u4eba\u6162\u6027\u671f\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u7684\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c(NCT02204644)\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: justify;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">2018\u5e747\u6708\uff0c<\/span><\/strong><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">CDE\u627f\u529e\u7532\u78fa\u9178\u6c1f\u9a6c\u66ff\u5c3c\u76841\u7c7b\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"list-style-type: none;-webkit-padding-start: 0px;-webkit-margin-before: 0px;-webkit-margin-after: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;white-space: normal;letter-spacing: 2px;background-color: rgb(255, 255, 255);font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537168526.jpeg\" alt=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\" title=\"2018\u5e747\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\uff08\u4e8c\uff09\"  \/><\/p>\n<p style=\"list-style-type: none;-webkit-padding-start: 0px;-webkit-margin-before: 0px;-webkit-margin-after: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;white-space: normal;letter-spacing: 2px;background-color: rgb(255, 255, 255);font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5f80\u671f\u7cbe\u5f69<\/span><\/strong><\/p>\n<p style=\"list-style-type: none;-webkit-padding-start: 0px;-webkit-margin-before: 0px;-webkit-margin-after: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;white-space: normal;letter-spacing: 2px;background-color: rgb(255, 255, 255);font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;text-decoration: underline;color: rgb(120, 172, 254);box-sizing: border-box !important;word-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231167&amp;idx=1&amp;sn=28235cb4fd7bb283cf83af16cc7d3a42&amp;chksm=84be7824b3c9f132888169756d6229bda5f6942392c2d5adf0678a7bd053afa3b48bf35d379d&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(120, 172, 254);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e00\u81f4\u6027\u8bc4\u4ef7\u76843\u5bb6\u4e0e3\u5e74<\/a><\/span><\/p>\n<p style=\"list-style-type: none;-webkit-padding-start: 0px;-webkit-margin-before: 0px;-webkit-margin-after: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;white-space: normal;letter-spacing: 2px;background-color: rgb(255, 255, 255);font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652230701&amp;idx=1&amp;sn=ea702ea398a915207c0901323d96697a&amp;chksm=84be79f6b3c9f0e08013a45f74ccb18f77b2470d83a0b6a500591ffc2970fa796b24166bd325&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(120, 172, 254);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6c47\u805a\u5357\u836f\u7275\u7ebf\u642d\u6865 &nbsp;\u6821\u4f01\u643a\u624b\u5171\u540c\u63a2\u7d22\u4eba\u624d\u57f9\u517b\u65b0\u6a21\u5f0f\u4e00\u4e00\u9996\u5c4aCRA\u4eba\u624d\u57f9\u8bad\u73ed\u7eaa\u5b9e<\/a><\/p>\n<p style=\"list-style-type: none;-webkit-padding-start: 0px;-webkit-margin-before: 0px;-webkit-margin-after: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;white-space: normal;letter-spacing: 2px;background-color: rgb(255, 255, 255);font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231162&amp;idx=1&amp;sn=7b4cf87e991464cf2205db0c1293d26f&amp;chksm=84be7821b3c9f13739102fa0302f2743f323e9c92658af76d99cd548cb37cba12cd3c96b1193&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u540c\u5fc3\u7b51\u68a6\u2014\u2014\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u4e0a\u6d77\u6821\u53cb\u4f1a\u5e74\u4f1a\u4fa7\u8bb0<\/a><\/p>\n<p style=\"list-style-type: none;-webkit-padding-start: 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