{"id":4355,"date":"2018-07-06T01:00:00","date_gmt":"2018-07-27T06:52:06","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/keytruda%e5%b7%a9%e5%9b%ba%e8%82%ba%e7%99%8c%e4%bc%98%e5%8a%bf%e5%86%8d%e4%b8%8b%e4%b8%80%e5%9f%8e\/"},"modified":"2018-07-27T14:52:08","modified_gmt":"2018-07-27T06:52:08","slug":"keytruda%e5%b7%a9%e5%9b%ba%e8%82%ba%e7%99%8c%e4%bc%98%e5%8a%bf%e5%86%8d%e4%b8%8b%e4%b8%80%e5%9f%8e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/4355\/","title":{"rendered":"Keytruda\u5de9\u56fa\u80ba\u764c\u4f18\u52bf\u518d\u4e0b\u4e00\u57ce"},"content":{"rendered":"
\n

\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/p>\n

\"Keytruda\u5de9\u56fa\u80ba\u764c\u4f18\u52bf\u518d\u4e0b\u4e00\u57ce\"<\/p>\n

7\u67082\u65e5\uff0c\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u516c\u53f8\u5ba3\u5e03\u7f8e\u56fdFDA\u5df2\u7ecf\u63a5\u53d7Keytruda\u8054\u5408\u5316\u7597\uff08\u5361\u94c2+\u7d2b\u6749\u9187\u6216\u767d\u86cb\u767d\u7d2b\u6749\u9187\uff09\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u8865\u5145\u751f\u7269\u5236\u5242\u8bb8\u53ef\u7533\u8bf7\uff08sBLA\uff09\uff0c\u540c\u65f6\u6388\u4e88\u8be5sBLA\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\uff08\u9884\u5b9a\u5ba1\u6279\u671f\u9650\u662f2018\u5e7410\u670830\u65e5\uff09\u3002<\/strong>\u8be5\u7533\u8bf7\u6709\u671b\u4f5c\u4e3a\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e00\u7ebf\u7597\u6cd5\uff0c\u800c\u4e0d\u7528\u8003\u8651PD-L1\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u8fd9\u662fKeytruda\u81ea\u53bb\u5e74FDA\u6279\u51c6\u7528\u4e8e\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e00\u7ebf\u6cbb\u7597\u540e\u5f97\u53c8\u4e00\u91cd\u5927\u7a81\u7834\u3002<\/strong><\/span><\/p>\n


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\"Keytruda\u5de9\u56fa\u80ba\u764c\u4f18\u52bf\u518d\u4e0b\u4e00\u57ce\"<\/p>\n

<\/span>
<\/p>\n

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<\/p>\n

\u91cd\u78c5\u6297PD-1\u7597\u6cd5KEYTRUDA\u7531\u9ed8\u6c99\u4e1c\u7814\u5236\u65e8\u5728\u63d0\u9ad8\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u68c0\u6d4b\u548c\u6297\u51fb\u80bf\u7624\u7ec6\u80de\u7684\u80fd\u529b\uff0c\u4e3a\u665a\u671f\u764c\u75c7\u60a3\u8005\u5e26\u6765\u5e0c\u671b\u3002\u5b83\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u963b\u65adPD-1\u53ca\u5176\u914d\u4f53PD-L1\u548cPD-L2\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6fc0\u6d3b\u53ef\u80fd\u5f71\u54cd\u80bf\u7624\u7ec6\u80de\u548c\u5065\u5eb7\u7ec6\u80de\u7684T\u6dcb\u5df4\u7ec6\u80de\u3002\u76ee\u524d\uff0cKeytruda\u5df2\u5728\u591a\u56fd\u83b7\u6279\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u3001NSCLC\u3001\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u3001\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u80c3\u764c\u7b49\u665a\u671f\u764c\u75c7\u3002<\/span><\/p>\n


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\"Keytruda\u5de9\u56fa\u80ba\u764c\u4f18\u52bf\u518d\u4e0b\u4e00\u57ce\"<\/p>\n

<\/span>
<\/p>\n

\u6b64\u6b21\u9ed8\u6c99\u4e1c\u9012\u4ea4\u7533\u8bf7\u4e3b\u8981\u662f\u57fa\u4e8eKeytruda\u7ec4\u5408\u7597\u6cd5\u7684\u4e09\u671f\u4e34\u5e8a—-KEYNOTE-407\u7814\u7a76\u6570\u636e\u3002Keytruda\u7ec4\u5408\u7597\u6cd5KEYNOTE-407\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u7528\u4e8e\u8bc4\u4f30PD-1\u6291\u5236\u5242KEYTRUDA\u00ae (pembrolizumab)\u8054\u5408\u5361\u94c2+\u7d2b\u6749\u9187\u6216\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\u7528\u4e8e\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e00\u7ebf\u6cbb\u7597\u7597\u6548\u3002\u8be5\u7814\u7a76\u5305\u542b\u4e86560\u4f8b\u672a\u7ecf\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u9cde\u72b6NSCLC\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u672a\u66fe\u63a5\u53d7\u8fc7\u9488\u5bf9\u665a\u671f\u75be\u75c5\u7684\u5168\u8eab\u6cbb\u7597\u3002\u4eca\u5e746\u6708\u4efd\u5728\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff092018\u5e74\u4f1a\u53d1\u5e03\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff1a\u4e0e\u5355\u72ec\u5316\u7597\u76f8\u6bd4\uff0cKeytruda\u52a0\u5316\u7597\u7684\u7ec4\u5408\u663e\u8457\u6539\u5584\u4e86OS\uff0c\u5c06\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e36%\uff08HR = 0.64 [95%CI\uff0c0.49-0.85]; p = 0.0008\uff09\u3002\u8fd9\u662f\u6297PD-1\u7597\u6cd5\u4e0e\u5316\u7597\u7ec4\u5408\u9996\u6b21\u5728\u9cde\u72b6NSCLC\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u4e2d\u663e\u793a\u80fd\u663e\u8457\u5ef6\u957fOS\u3002\u6b64\u5916\uff0c\u8fd9\u6b3e\u7ec4\u5408\u4e5f\u5e26\u6765\u4e86\u663e\u8457\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u76ca\u5904\u3002<\/span><\/p>\n


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\u503c\u5f97\u6ce8\u610f\u7684\u662f\u5728\u6b64\u4e4b\u524dKeytruda\u5df2\u7ecf\u62ff\u5230\u4e24\u9879\u4e00\u7ebf\u6cbb\u7597NSCLC\u7684\u9002\u5e94\u75c7\u30022015\u5e7410\u67082\u65e5\uff0cFDA\u57fa\u4e8eKEYNOTE-024\u7814\u7a76\u6570\u636e\u6279\u51c6Keytruda\u5355\u836f\u4e00\u7ebf\u6cbb\u7597PD-L1\u8868\u8fbe\u6c34\u5e73\u226550%\u4e14\u6ca1\u6709EGFR\u6216ALK\u57fa\u56e0\u7a81\u53d8\u7684\u8f6c\u79fb\u6027NSCLC\u30022017\/5\/10\uff0cFDA\u57fa\u4e8eKEYNOTE-021\u7814\u7a76\u6570\u636e\u6279\u51c6Keytruda\u8054\u5408\u5316\u7597\uff08\u57f9\u7f8e\u66f2\u585e+\u5361\u94c2\uff09\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u975e\u9cde\u72b6NSCLC\uff0c\u5982\u679c\u6b64\u6b21\u8865\u5145\u7533\u8bf7\u518d\u6b21\u83b7\u6279\uff0cKeytruda\u6709\u671b\u6210\u4e3a\u6240\u6709NSCLC\u60a3\u8005\uff08\u4e0d\u533a\u5206PD-L1\u8868\u8fbe\u6c34\u5e73\uff09\u7684\u4e00\u7ebf\u6807\u51c6\u7597\u6cd5\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u9ed8\u6c99\u4e1c\u7814\u7a76\u5b9e\u9a8c\u5ba4\u9ad8\u7ea7\u526f\u603b\u88c1\u3001\u9996\u5e2d\u533b\u7597\u5b98\u53ca\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u8d1f\u8d23\u4ebaRoy Baynes\u535a\u58eb\u8868\u793a\uff0cKeytruda\u5df2\u88ab\u786e\u7acb\u4e3aNSCLC\u4e00\u7ebf\u6cbb\u7597\u7684\u91cd\u8981\u65b9\u6848\uff0c\u968f\u7740\u80ba\u764c\u9886\u57df\u5e7f\u6cdb\u7684\u5f00\u53d1\u9879\u76ee\uff0c\u6211\u4eec\u81f4\u529b\u4e8e\u5c3d\u53ef\u80fd\u591a\u7684\u60a3\u8005\u7684\u3002<\/span><\/p>\n


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\u58f0\u660e\uff1a\u8f6c\u8f7d\u8bf7\u52a1\u5fc5\u6ce8\u660e\u672c\u6587\u6765\u6e90\u53ca\u4f5c\u8005\u3002<\/strong>
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\u4f5c\u8005\u6587\u7ae0\u63a8\u8350\uff1a<\/span><\/section>\n

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\n
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FDA\u6279\u51c6\u767d\u8840\u75c5\u65b0\u7597\u6cd5<\/span><\/a><\/h2>\n

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Abbvie\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u65b0\u836fUpadacitinib\u62b53\u671f\u4e34\u5e8a\u7ec8\u70b9<\/a><\/span><\/h2>\n

\u6052\u745e\u533b\u836fCDK4\/6\u6291\u5236\u5242\u8fdb\u5165II\u671f\u4e34\u5e8a<\/a><\/span><\/h2>\n

\u5f53Keytruda\u9047\u4e0aLenvatinib<\/a><\/span><\/h2>\n

\u4e5f\u8c08\u524d\u5217\u817a\u764c\u91cd\u78c5\u836f\u7269\u2014\u2014apalutamide<\/a><\/span><\/h2>\n

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\u8c01\u80fd\u6253\u7834Theranos\u9b54\u5492<\/a><\/span><\/h2>\n

\u5c55\u671b2018\uff0c\u751f\u7269\u533b\u836f\u516c\u53f8\u8868\u73b0\u53ef\u671f<\/span><\/a><\/h2>\n

\u5f53\u836f\u7269\u7814\u53d1\u9047\u4e0aAI<\/a><\/span><\/h2>\n

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\u793c\u6765\u8054\u624b\u5fb7\u5eb7\u533b\u7597\u6253\u9020\u7cd6\u5c3f\u75c5\u6570\u5b57\u5065\u5eb7\u4ea7\u54c1<\/a><\/span><\/h2>\n

\u91cd\u78c5\uff01PD-1\u795e\u836fNivolumab\u6709\u671b\u8fd1\u671f\u8fdb\u5165\u4e2d\u56fd\u5e02\u573a<\/a><\/span><\/h2>\n<\/section>\n<\/section>\n
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\u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n

\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"Keytruda\u5de9\u56fa\u80ba\u764c\u4f18\u52bf\u518d\u4e0b\u4e00\u57ce\"<\/p>\n


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\u884c\u821fDrug<\/span><\/p>\n<\/section>\n

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\u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n

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\n<\/section>\n


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\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u884c\u821fDrug <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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