{"id":43694,"date":"2018-08-31T01:00:00","date_gmt":"2018-09-17T07:18:01","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e5%a8%81%e6%ad%a6%ef%bc%81%e4%b8%ad%e5%9b%bd%e5%ad%a6%e8%80%85%e8%bd%ae%e7%95%aa%e7%99%bb%e5%9c%ba%e7%a7%91%e7%a0%94%e5%9c%a3%e6%ae%bf%ef%bc%81\/"},"modified":"2018-09-17T15:18:04","modified_gmt":"2018-09-17T07:18:04","slug":"%e5%a8%81%e6%ad%a6%ef%bc%81%e4%b8%ad%e5%9b%bd%e5%ad%a6%e8%80%85%e8%bd%ae%e7%95%aa%e7%99%bb%e5%9c%ba%e7%a7%91%e7%a0%94%e5%9c%a3%e6%ae%bf%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/43694\/","title":{"rendered":"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img style=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537168682.jpeg\" alt=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\" title=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\"  \/><\/p>\n<p><br  \/><\/p>\n<section   >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"border-left-color:rgb(24, 114, 186);border-right-color:rgb(24, 114, 186);border-style:solid;border-width:0px 0px 0px 3px;box-sizing:border-box;display:inline-block;padding:10px;width:100%;\" >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\"><span style=\"color: rgb(178, 178, 178);\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" justify=\"justify\" rgb=\"rgb\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\">\u672c\u6587\u7cfb\u751f\u7269\u8c37\u539f\u521b\u7f16\u8bd1\uff0c\u6b22\u8fce\u5206\u4eab\uff0c\u8f6c\u8f7d\u987b\u6388\u6743\uff01<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(51, 51, 51);\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" rgb=\"rgb\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" center=\"center\" normal=\"normal\" important=\"important\" em=\"em\" break-word=\"break-word\"><br  \/><\/p>\n<section   >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin: 30px 0% 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 90%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(254, 255, 255);box-shadow: rgb(220, 221, 221) 3.53px 3.53px 0px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: -28px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;border-width: 2px;border-style: solid;border-color: rgb(255, 255, 255);padding: 0.1em 0.3em;background-color: rgb(255, 255, 255);color: rgb(13, 0, 21);font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><strong style=\"color: rgb(13, 0, 21);\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" rgb=\"rgb\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" center=\"center\" normal=\"normal\" important=\"important\" break-word=\"break-word\" border-box=\"border-box\"><span style=\"max-width: 100%;background-color: rgb(24, 114, 186);color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">&nbsp;\u8c37 \u541b \u8bf4<\/strong><\/span><span style=\"max-width: 100%;color: rgb(76, 76, 76);background-color: rgb(24, 114, 186);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">&nbsp;<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 24px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;padding-left: 0em;padding-right: 0em;text-align: left;\"><span style=\"color: rgb(76, 76, 76);\"><span style=\"\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" justify=\"justify\" rgb=\"rgb\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" important=\"important\" break-word=\"break-word\" border-box=\"border-box\">6\u6708~8\u6708\u6211\u56fd\u79d1\u5b66\u5bb6\u53d1\u8868\u7684\u90e8\u5206\u91cd\u8981\u7814\u7a76\u6210\u679c\uff0c<\/span><span style=\"\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" justify=\"justify\" rgb=\"rgb\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\">\u5206\u4eab\u7ed9\u5927\u5bb6\uff01<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" rgb=\"rgb\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" center=\"center\" normal=\"normal\" important=\"important\" em=\"em\" break-word=\"break-word\" border-box=\"border-box\"><br  \/><\/p>\n<p style=\"margin-top: 5px;margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;word-wrap: break-word;min-height: 1em;color: rgb(51, 51, 51);\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" center=\"center\" normal=\"normal\" important=\"important\" border-box=\"border-box\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;background-color: rgb(24, 114, 186);color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;\u4e2d\u56fd\u79d1\u5b66\u5bb6\u91cd\u8981\u7814\u7a76\u6210\u679c&nbsp;<\/span><\/strong><\/p>\n<p style=\"margin-top: 5px;margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;word-wrap: break-word;min-height: 1em;color: rgb(51, 51, 51);\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" center=\"center\" normal=\"normal\" important=\"important\" border-box=\"border-box\"><span style=\"max-width: 100%;font-size: 12px;color: rgb(214, 214, 214);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;\u6587\/T.Shen<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" rgb=\"rgb\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" center=\"center\" normal=\"normal\" important=\"important\" em=\"em\" break-word=\"break-word\" border-box=\"border-box\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" rgb=\"rgb\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" center=\"center\" normal=\"normal\" important=\"important\" em=\"em\" break-word=\"break-word\" border-box=\"border-box\"><img style=\"width: 362px !important;height: auto !important;\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537168682-1.jpeg\" alt=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\" title=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\"  \/><br  \/><\/p>\n<p style=\"text-align: center;padding-left: 1em;padding-right: 1em;\"><span style=\"color: rgb(214, 214, 214);\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" rgb=\"rgb\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" center=\"center\">\u56fe\u7247\u6765\u6e90<\/span><span style=\"color: rgb(214, 214, 214);\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" rgb=\"rgb\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" center=\"center\">\uff1apintere<\/span><span style=\"color: rgb(214, 214, 214);\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" rgb=\"rgb\" microsoft=\"microsoft\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" center=\"center\">st<\/span><br  \/><\/p>\n<p style=\"text-align: center;padding-left: 1em;padding-right: 1em;\"><br  \/><\/p>\n<p style=\"text-align: center;padding-left: 1em;padding-right: 1em;\"><br  \/><\/p>\n<section style=\"padding-left: 1em;padding-right: 1em;\"   >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"border-left-color:rgb(24, 114, 186);border-right-color:rgb(24, 114, 186);border-style:solid;border-width:0px 0px 0px 3px;box-sizing:border-box;display:inline-block;padding:10px;width:100%;\" >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\"><strong><span style=\"color: rgb(24, 114, 186);\">Science\uff1a\u989c\u5b81\u8bfe\u9898\u7ec4\u4ece\u7ed3\u6784\u4e0a\u63ed\u793a\u4ebaPtch1\u86cb\u767d\u8bc6\u522bShh\u673a\u5236<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"color: rgb(214, 214, 214);font-size: 12px;\">doi\uff1a10.1126\/science.aas8935<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">Hedgehog\uff08Hh\uff09\u901a\u8def\u5bf9<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u80da\u80ce\u53d1\u751f\u548c\u7ec4\u7ec7\u518d\u751f<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002Hh\u4fe1\u53f7\u662f\u901a\u8fc7\u5206\u6ccc\u7684\u548c\u8102\u8d28\u4fee\u9970\u7684\u86cb\u767dHh\u7ed3\u5408\u5230\u819c\u53d7\u4f53Patched\uff08Ptch\uff09\u4e0a\u800c\u88ab\u6fc0\u6d3b\u7684\u3002\u5728\u7f3a\u4e4fHh\u7684\u60c5\u51b5\u4e0b\uff0cPtch\u901a\u8fc7\u4e00\u79cd\u672a\u77e5\u7684\u95f4\u63a5\u673a\u5236\u6291\u5236\u4e0b\u6e38\u7684G\u86cb\u767d\u5076\u8054\u53d7\u4f53Smoothened\uff08Smo\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: center;letter-spacing: 1px;line-height: 1.75em;\"><img style=\"width: 70% !important;height: auto !important;visibility: visible !important;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537168682.jpeg\" alt=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\" title=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: center;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" rgb=\"rgb\" microsoft=\"microsoft\" yahei=\"yahei\">\u56fe\u7247\u6765\u81eaScience, doi:10.1126\/science.aas8935\u3002<\/span><\/p>\n<p style=\"padding-left: 1em;padding-right: 1em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">Hh\u4e0ePtch\u7684\u7ed3\u5408\u51cf\u8f7b\u4e86\u5bf9Smo\u7684\u6291\u5236\u5e76\u4e14\u5f00\u542f\u8ba9Hh\u901a\u8def\u906d\u53d7\u8f6c\u5f55\u6fc0\u6d3b\u7684\u4fe1\u53f7\u8f6c\u5bfc\u4e8b\u4ef6\u3002Hh\u4fe1\u53f7\u5f02\u5e38\u4e0e\u51fa\u751f\u7f3a\u9677\u6216\u80bf\u7624\u53d1\u751f\u6709\u5173\u3002\u5c3d\u7ba1\u8fdb\u884c\u4e86\u4e25\u5bc6\u7684\u7814\u7a76\uff0cHh\u3001Ptch\u548cSmo\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u5206\u5b50\u57fa\u7840\u4ecd\u662f\u4e0d\u6e05\u695a\u7684\uff0c\u800c\u4e14Ptch\u548cHh\u4e4b\u95f4\u8bc6\u522b\u7684\u7ed3\u6784\u57fa\u7840\u8fd8\u6709\u5f85\u9610\u660e\u3002<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u7ecf\u9884\u6d4b\u957f<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">1447\u4e2a<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u6c28\u57fa\u9178\u6b8b\u57fa\u7684\u4ebaPtch1\u86cb\u767d\u542b\u6709<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">12\u4e2a<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u8de8\u819c\u533a\u6bb5\uff08TM\uff09\uff0c\u5e76\u4e14\u4e0e\u7ec6\u83ccRND\u5bb6\u65cf\u8f6c\u8fd0\u86cb\u767d\uff08resistance-nodulation-division family transporter\uff0c RND\u5bb6\u65cf\u8f6c\u8fd0\u86cb\u767d\uff09\u5b58\u5728\u7740\u7ed3\u6784\u7c7b\u4f3c\u6027\u3002Ptch1\u7684\u8de8\u819c\u533a\u6bb52\uff08TM2\uff09\u81f3TM6\u6784\u6210\u56fa\u9187\u654f\u611f\u591a\u80bd\u533a\uff08sterol-sensing domain\uff0c SSD\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<section style=\"padding-right: 1em;padding-left: 1em;white-space: normal;\"   >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"padding: 10px;border-width: 0px 0px 0px 3px;border-style: solid;border-left-color: rgb(24, 114, 186);border-right-color: rgb(24, 114, 186);box-sizing: border-box;display: inline-block;width: 526px;\" >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\"><strong><span style=\"color: rgb(24, 114, 186);\">Science\uff1a\u63ed\u793a\u80ba\u795e\u7ecf\u5185\u5206\u6ccc\u7ec6\u80de\u6269\u5927\u8fc7\u654f\u6027\u54ee\u5598\u53cd\u5e94\u673a\u5236<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u80ba\u90e8\u5177\u6709\u8f83\u5927\u7684\u8868\u9762\u9762\u79ef\uff0c\u80fd\u591f\u68c0\u6d4b\u5438\u5165\u7a7a\u6c14\u4e2d\u7684\u4fe1\u53f7\u5e76\u5bf9\u5b83\u4eec\u4f5c\u51fa\u53cd\u5e94\u3002\u80ba\u90e8\u548c\u73af\u5883\u4e4b\u95f4\u7684\u5f02\u5e38\u76f8\u4e92\u4f5c\u7528\u5bfc\u81f4\u8bb8\u591a\u75be\u75c5\uff0c\u5982\u54ee\u5598\u3002<\/span><br  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4f53\u5916\u6570\u636e\u8868\u660e<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u80ba\u795e\u7ecf\u5185\u5206\u6ccc\u7ec6\u80de<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\uff08pulmonary neuroendocrine cell\uff0c PNEC\uff09\u662f\u4e00\u7c7b\u7f55\u89c1\u7684<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\uff0c\u53ef\u8d77\u7740<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u5316\u5b66\u4f20\u611f\u5668<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u7684\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4e00\u65e6\u5728\u4f53\u5916\u57f9\u517b\u4e2d\u53d7\u5230\u523a\u6fc0\uff0c\u5b83\u4eec\u4f1a\u91ca\u653e\u51fa\u5bcc\u542b\u795e\u7ecf\u80bd\u3001\u80fa\u7c7b\u5316\u5408\u7269\u548c\u795e\u7ecf\u9012\u8d28\u7684\u81f4\u5bc6\u6838\u5fc3\u56ca\u6ce1\u3002\u8fd9\u4e9b\u751f\u7269\u6d3b\u6027\u5206\u5b50\u80fd\u591f\u5f15\u53d1<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u514d\u75ab\u53cd\u5e94<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u548c<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u751f\u7406\u53cd\u5e94<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u6700\u8fd1\u5f00\u5c55\u7684\u4e00\u9879\u4f53\u5185\u7814\u7a76\u63ed\u793a\u51faPNEC\u6b63\u5e38\u5730\u5f62\u6210\u88ab\u79f0\u4f5c\u795e\u7ecf\u4e0a\u76ae\u5c0f\u4f53\uff08neuroepithelial body\uff09\u7684\u81ea\u805a\u96c6\u5355\u5143\u662f\u9650\u5236\u521d\u59cb\u80ba\u90e8\uff08<span style=\"color: rgb(37, 37, 37);\" arial=\"arial\" sans-serif=\"sans-serif\" rgb=\"rgb\" microsoft=\"microsoft\" yahei=\"yahei\">na\u00efve lung<\/span>\uff09\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u6570\u91cf\u6240\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u7136\u800c\uff0c\u4eba\u4eec\u5e76\u4e0d\u6e05\u695aPNEC\u662f\u5426\u80fd\u591f\u5728\u4f53\u5185\u5c06\u5916\u6e90\u6027\u6c14\u9053\u4fe1\u53f7\uff08\u5982\u8fc7\u654f\u539f\uff09\u8f6c\u5316\u4e3a\u4e0b\u6e38\u7ea7\u8054\u53cd\u5e94\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: center;letter-spacing: 1px;\"><img style=\"border-style: none;border-color: initial;width: 289.29px !important;height: auto !important;color: rgb(37, 37, 37);\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537168683.jpg\" alt=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\" title=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: center;letter-spacing: 1px;\"><span style=\"font-size: 12px;color: rgb(214, 214, 214);\">\u56fe\u7247\u6765\u81eaScience\u671f\u520a\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;\"><br  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4e3a\u4e86\u68c0\u9a8cPNEC\u5728\u80ba\u90e8\u4e2d\u8d77\u7740\u5316\u5b66\u4f20\u611f\u5668\u4f5c\u7528\u7684\u5047\u8bbe\uff0c\u6765\u81ea\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u3001\u5a01\u65af\u5eb7\u661f\u5927\u5b66\u9ea6\u8fea\u900a\u5206\u6821\u3001\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u3001\u534e\u76db\u987f\u5927\u5b66\u548c\u4e2d\u56fd\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u8ba9\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u4e2d\u7684Ascl1\u5931\u6d3b\u57f9\u80b2\u51fa\u7f3a\u4e4fPNEC\u7684\u5c0f\u9f20\u7a81\u53d8\u4f53\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4ed6\u4eec\u9075\u7167\u73b0\u5b58\u7684\u54ee\u5598\u6a21\u578b\u89c4\u5b9a\uff0c\u8ba9\u8fd9\u4e9b\u5c0f\u9f20\u7a81\u53d8\u4f53\u63a5\u89e6\u5375\u6e05\u86cb\u767d\u6216\u5c4b\u5c18\u87a8\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: center;letter-spacing: 1px;line-height: 1.75em;\"><br  \/><\/p>\n<section style=\"padding-right: 1em;padding-left: 1em;white-space: normal;\"   >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"padding: 10px;border-width: 0px 0px 0px 3px;border-style: solid;border-left-color: rgb(24, 114, 186);border-right-color: rgb(24, 114, 186);box-sizing: border-box;display: inline-block;width: 526px;\" >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\"><strong><span style=\"color: rgb(24, 114, 186);\">Science\uff1a\u9274\u5b9a\u51fa\u6709\u52a9\u8c03\u8282\u8840\u6db2\u80c6\u56fa\u9187\u6c34\u5e73\u7684LIMA1\u57fa\u56e0\u7a81\u53d8<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 12px;color: rgb(214, 214, 214);\">doi\uff1a10.1126\/science.aao6575<\/span><br  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;\"><br  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u79d1\u5b66\u9662\u5927\u5b66\u3001\u6b66\u6c49\u5927\u5b66\u3001\u65b0\u7586\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u3001\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u548c\u4e2d\u79d1\u9662\u4e0a\u6d77\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u7684\u7814\u7a76\u4eba\u5458\u9274\u5b9a\u51fa\u4e00\u79cd\u81f3\u5c11\u90e8\u5206\u5730\u8d1f\u8d23\u8c03\u8282\u8840\u6db2\u4e2d\u7684\u80c6\u56fa\u9187\u6c34\u5e73\u7684\u57fa\u56e0\u7a81\u53d8\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">2018\u5e746\u67088\u65e5<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u7684<\/span><em><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">Science<\/span><\/strong><\/em><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cA LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption\u201d\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u5728\u8fd9\u7bc7\u8bba\u6587\u4e2d\uff0c\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u63cf\u8ff0\u4e86\u4ed6\u4eec\u5982\u4f55\u8ffd\u8e2a\u7f16\u7801\u53c2\u4e0e\u8fd9\u4e2a\u8fc7\u7a0b\u7684\u4e00\u4e2a\u5173\u952e\u86cb\u767d\u7684\u57fa\u56e0\u53d1\u751f\u7684\u7a81\u53d8\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: center;letter-spacing: 1px;line-height: 1.75em;\"><img style=\"width: 447.09px !important;height: auto !important;visibility: visible !important;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537168683.jpeg\" alt=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\" title=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: center;letter-spacing: 1px;\"><span style=\"\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" rgb=\"rgb\" microsoft=\"microsoft\" yahei=\"yahei\">\u56fe\u7247\u6765\u81eaStrong M: Protein Nanomachines. PLoS Biol 2\/3\/2004: e73.&nbsp;<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: center;letter-spacing: 1px;\"><span style=\"\" arial=\"arial\" sans-serif=\"sans-serif\" px=\"px\" rgb=\"rgb\" microsoft=\"microsoft\" yahei=\"yahei\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u6b63\u5982\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u6307\u51fa\u7684\u90a3\u6837\uff0c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\u80fd\u591f\u5806\u79ef\u5728\u52a8\u8109\u4e2d\uff0c\u4ece\u800c\u5bfc\u81f4\u5fc3\u810f\u75c5\u548c\u4e2d\u98ce\u3002\u51fa\u4e8e\u8fd9\u4e2a\u539f\u56e0\uff0c\u4e86\u89e3\u662f\u4ec0\u4e48\u5bfc\u81f4\u8fd9\u4e00\u70b9\u662f\u6709\u6240\u5e2e\u52a9\u7684\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4e4b\u524d\u7684\u7814\u7a76\u5df2\u8868\u660e\u9057\u4f20\u56e0\u7d20\u5728\u6444\u53d6\u542b\u6709LDL-C\u7684\u98df\u7269\u4f1a\u53d1\u751f\u4ec0\u4e48\u7ed3\u679c\u4e2d\u8d77\u4f5c\u7528\u3002\u4f46\u662f\uff0c\u54ea\u4e9b\u9057\u4f20\u56e0\u7d20\u5bfc\u81f4LDL-C\u5728\u67d0\u4e9b\u4eba\u7684\u52a8\u8109\u4e2d\u66f4\u591a\u5730\u5806\u79ef\u800c\u5728\u5176\u4ed6\u4eba\u7684\u52a8\u8109\u4e2d\u66f4\u5c11\u5730\u5806\u79ef\uff1f<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: justify;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u5728\u8fd9\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u8bd5\u56fe\u66f4\u591a\u5730\u4e86\u89e3\u8fd9\u4e9b\u9057\u4f20\u56e0\u7d20\u3002<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><br  \/><\/p>\n<section style=\"padding-left: 1em;padding-right: 1em;\"   >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"border-left-color:rgb(24, 114, 186);border-right-color:rgb(24, 114, 186);border-style:solid;border-width:0px 0px 0px 3px;box-sizing:border-box;display:inline-block;padding:10px;width:100%;\" >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\"><strong><span style=\"color: rgb(24, 114, 186);\">Protein Cell\uff1a\u8fdb\u4e00\u6b65\u4f18\u5316\u817a\u560c\u5464\u78b1\u57fa\u7f16\u8f91\u7cfb\u7edf<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"color: rgb(214, 214, 214);font-size: 12px;\">doi\uff1a10.1007\/s13238-018-0568-x&nbsp;&nbsp;&nbsp; doi\uff1a10.1007\/s13238-018-0566-z<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u5728\u4e24\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u548c\u4e2d\u5c71\u5927\u5b66\u7684\u4e24\u4e2a\u7814\u7a76\u5c0f\u7ec4\u5728\u5c0f\u9f20\u548c\u5927\u9f20\u54c1\u7cfb\u4e2d\u5f00\u53d1\u51fa\u4e00\u79cd\u88ab\u79f0\u4f5c<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u817a\u560c\u5464\u78b1\u57fa\u7f16\u8f91\u5668<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\uff08adenine base editor\uff0c ABE\uff09\u7684\u78b1\u57fa\u7f16\u8f91\u7cfb\u7edf\uff0c\u5e76\u5bf9\u8fd9\u79cd\u7cfb\u7edf\u52a0\u4ee5\u6539\u8fdb\uff0c\u8fd9\u5c06\u5bf9\u4eba\u7c7b\u9057\u4f20\u75be\u75c5\u548c\u57fa\u56e0\u7597\u6cd5\u5e26\u6765\u91cd\u5927\u7684\u5f71\u54cd\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728\u5f00\u653e\u5b58\u53d6\u7684<\/span><em><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">Protein &amp; Cell<\/span><\/strong><\/em><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u671f\u520a\u4e0a\u3002<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: center;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;\"><img style=\"border-style: none;border-color: initial;width: 75% !important;height: auto !important;visibility: visible !important;word-wrap: break-word;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537168683.jpeg\" alt=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\" title=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\"  \/><\/p>\n<p style=\"text-align: center;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;\"><span style=\"font-size: 12px;color: rgb(214, 214, 214);\">\u56fe\u7247\u6765\u81eaProtein &amp; Cell, doi:10.1007\/s13238-018-0568-x.<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4eba\u57fa\u56e0\u7531\u78b1\u57faA\u3001T\u3001C\u548cG\u7ec4\u6210\uff0c\u8fd9\u4e9b\u78b1\u57fa\u4ee5\u7279\u5b9a\u7684\u987a\u5e8f\u6392\u5217\u5728\u4e00\u8d77\u6765\u7f16\u7801\u9057\u4f20\u4fe1\u606f\u3002\u8fd9\u79cdABE\u7cfb\u7edf\u80fd\u591f\u4ea7\u751f\u6240\u9700\u7684A\u2192G\u8f6c\u5316\uff0c\u56e0\u800c\u5141\u8bb8\u79d1\u5b66\u5bb6\u4eec\u6539\u53d8\u9057\u4f20\u5bc6\u7801\uff0c\u540c\u65f6\u8ba9\u4e0d\u60f3\u8981\u7684\u7ed3\u679c\u6700\u5c0f\u5316\u3002\u9274\u4e8e\u51e0\u4e4e\u4e00\u534a\u7684\u4eba\u7c7b\u9057\u4f20\u75be\u75c5\u662f\u7531C\/G\u2192T\/C\u7a81\u53d8\u5f15\u8d77\u7684\uff0c\u8fd9\u6700\u597d\u662f\u901a\u8fc7ABE\u7cfb\u7edf\u52a0\u4ee5\u6821\u6b63\uff0c\u56e0\u6b64\u5b83\u662f\u4e00\u79cd\u6709\u524d\u666f\u7684\u6cbb\u7597\u5e94\u7528\u6280\u672f\u3002<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u5c0f\u9f20\u548c\u5927\u9f20\u662f\u751f\u7269\u5b66\u548c\u533b\u5b66\u7814\u7a76\u4e2d\u6700\u4e3a\u91cd\u8981\u7684\u4e24\u79cd\u6a21\u5f0f\u751f\u7269\uff0c\u8fd9\u662f\u56e0\u4e3a\u5b83\u4eec\u5f88\u5bb9\u6613\u7e41\u6b96\u5e76\u4e14\u5728\u751f\u7406\u4e0a\u4e0e\u4eba\u7c7b\u76f8\u4f3c\u3002\u5229\u7528\u7ecf\u8fc7\u57fa\u56e0\u4fee\u9970\u7684\u556e\u9f7f\u7c7b\u52a8\u7269\u6a21\u578b\uff0c\u79d1\u5b66\u5bb6\u4eec\u5728\u7406\u89e3\u4eba\u7c7b\u751f\u7269\u5b66\u3001\u75be\u75c5\u75c5\u7406\u5b66\u548c\u5f00\u53d1\u6cbb\u7597\u591a\u79cd\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u6cd5\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\u3002\u7136\u800c\uff0c\u5373\u4f7f\u4f7f\u7528\u50cfCRISPR\/Cas9\u8fd9\u6837\u7684\u9776\u5411\u57fa\u56e0\u7ec4\u7f16\u8f91\u6280\u672f\uff0c\u4e5f\u4e0d\u5bb9\u6613\u57f9\u80b2\u51fa\u542b\u6709\u5728\u4eba\u7c7b\u75be\u75c5\u4e2d\u9274\u5b9a\u5904\u7684\u70b9\u7a81\u53d8\u7684\u5c0f\u9f20\u6216\u5927\u9f20\u54c1\u7cfb\u3002<\/span><\/p>\n<p style=\"text-align: center;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><br  \/><\/p>\n<section style=\"padding-left: 1em;padding-right: 1em;\"   >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"border-left-color:rgb(24, 114, 186);border-right-color:rgb(24, 114, 186);border-style:solid;border-width:0px 0px 0px 3px;box-sizing:border-box;display:inline-block;padding:10px;width:100%;\" >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\"><strong><span style=\"color: rgb(24, 114, 186);\">Cell Metab\uff1a\u63ed\u793a\u8102\u80aa\u6444\u5165\u662f\u4f53\u91cd\u589e\u52a0\u7684\u552f\u4e00\u539f\u56e0<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 12px;color: rgb(214, 214, 214);\">doi\uff1a10.1016\/j.cmet.2018.06.010<\/span><br  \/><\/p>\n<p style=\"padding-left: 1em;padding-right: 1em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u79d1\u5b66\u9662\u5927\u5b66\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u9057\u4f20\u4e0e\u53d1\u80b2\u751f\u7269\u5b66\u7814\u7a76\u6240\u3001\u5e7f\u4e1c\u7701\u751f\u7269\u8d44\u6e90\u5e94\u7528\u7814\u7a76\u6240\u548c\u5927\u7406\u5927\u5b66\u7b49\u7814\u7a76\u673a\u6784\u7684\u7814\u7a76\u4eba\u5458\u5728\u4e00\u9879\u8fc4\u4eca\u4e3a\u6b62\u6700\u5927\u89c4\u6a21\u7684\u7814\u7a76\u4e2d\u7814\u7a76\u996e\u98df\u4e2d\u7684\u54ea\u4e9b\u6210\u5206&#8212;<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u8102\u80aa\u3001\u78b3\u6c34\u5316\u5408\u7269<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u6216<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u86cb\u767d<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">&#8212;\u4f1a\u5bfc\u81f4\u5c0f\u9f20\u7684<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u4f53\u91cd\u589e\u52a0<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">2018\u5e747\u670812\u65e5<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u5728\u7ebf\u53d1\u8868\u5728<\/span><em><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">Cell Metabolism<\/span><\/strong><\/em><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u671f\u520a\u4e0a\u3002<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: center;letter-spacing: 1px;line-height: 1.75em;\"><img style=\"width: 65% !important;height: auto !important;visibility: visible !important;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537168684.jpeg\" alt=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\" title=\"\u5a01\u6b66\uff01\u4e2d\u56fd\u5b66\u8005\u8f6e\u756a\u767b\u573a\u79d1\u7814\u5723\u6bbf\uff01\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;white-space: normal;text-align: center;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 12px;color: rgb(214, 214, 214);\"><span style=\"\" arial=\"arial\" sans-serif=\"sans-serif\" rgb=\"rgb\" microsoft=\"microsoft\" yahei=\"yahei\">\u56fe\u7247\u6765\u81ea<\/span><span style=\"word-wrap: break-word;\" arial=\"arial\" sans-serif=\"sans-serif\" rgb=\"rgb\" microsoft=\"microsoft\" yahei=\"yahei\" italic=\"italic\">Cell Metabolism<\/span><span style=\"\" arial=\"arial\" sans-serif=\"sans-serif\" rgb=\"rgb\" microsoft=\"microsoft\" yahei=\"yahei\">, doi:10.1016\/j.cmet.2018.06.010\u3002<\/span><\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u9274\u4e8e\u98df\u7269\u7531\u8102\u80aa\u3001\u78b3\u6c34\u5316\u5408\u7269\u548c\u86cb\u767d\u7ec4\u6210\uff0c\u56e0\u6b64\u5f88\u96be\u786e\u5207\u5730\u6307\u51fa\u4e00\u822c\u996e\u98df\u4e2d\u7684\u54ea\u4e9b\u6210\u5206\u4f1a\u5bfc\u81f4\u4f53\u91cd\u589e\u52a0\u3002<\/span><\/p>\n<p style=\"padding-left: 1em;padding-right: 1em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u95ee\u9898\u7684\u4e00\u90e8\u5206\u662f\uff0c\u5f88\u96be\u5bf9\u4eba\u4eec\u5403\u7684\u4e1c\u897f\u8fdb\u884c\u8db3\u591f\u957f\u65f6\u95f4\u7684\u63a7\u5236\u4ee5\u4fbf\u786e\u5b9a\u54ea\u4e9b\u6210\u5206\u662f\u6700\u4e3a\u91cd\u8981\u7684\u56e0\u7d20\uff0c\u7136\u800c\uff0c\u9488\u5bf9\u52a8\u7269\u7684\u7c7b\u4f3c\u7814\u7a76\u80fd\u591f\u6709\u52a9\u6307\u51fa\u6b63\u786e\u7684\u65b9\u5411\u3002<\/span><\/p>\n<p style=\"padding-left: 1em;padding-right: 1em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u8fd9\u9879\u65b0\u7684\u7814\u7a76\u5305\u62ec<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">30\u79cd<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4e0d\u540c\u7684\u996e\u98df\uff0c\u6bcf\u79cd\u996e\u98df\u5177\u6709\u4e0d\u540c\u7684\u8102\u80aa\u3001\u78b3\u6c34\u5316\u5408\u7269\uff08\u7cd6\uff09\u548c\u86cb\u767d\u542b\u91cf\u3002\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u7ed9\u5c0f\u9f20\u5582\u98df\u8fd9\u4e9b\u996e\u98df\u4e09\u4e2a\u6708\uff0c\u8fd9\u76f8\u5f53\u4e8e\u4eba\u7c7b\u7684\u4e5d\u5e74\u3002\u4ed6\u4eec\u603b\u5171\u5bf9\u8fd9\u4e9b\u5c0f\u9f20\u7684\u4f53\u91cd\u53d8\u5316\u8fdb\u884c\u4e86<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">100000\u591a\u6b21<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u6d4b\u91cf\uff0c\u5e76\u4e14\u4f7f\u7528\u5fae\u578b\u78c1\u5171\u632f\u6210\u50cf\u4eea\u5668\u6d4b\u91cf\u5b83\u4eec\u7684\u4f53\u8102\u91cd\u3002\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u662f\u660e\u786e\u7684\uff0c\u5373\u8ba9\u8fd9\u4e9b<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u5c0f\u9f20\u53d8\u80d6<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u7684\u552f\u4e00\u539f\u56e0\u5c31\u662f\u5b83\u4eec\u5728<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u996e\u98df\u4e2d\u6444\u5165<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4e86\u66f4\u591a\u7684<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u8102\u80aa<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u3002<\/span><\/p>\n<p style=\"padding-left: 1em;padding-right: 1em;\"><br  \/><\/p>\n<section style=\"padding-left: 1em;padding-right: 1em;\"   >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"border-left-color:rgb(24, 114, 186);border-right-color:rgb(24, 114, 186);border-style:solid;border-width:0px 0px 0px 3px;box-sizing:border-box;display:inline-block;padding:10px;width:100%;\" >\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\"><strong><span style=\"color: rgb(24, 114, 186);\">Lancet Oncology\uff1a\u9996\u6b21\u53d1\u5e03\u4e2d\u56fd\u5927\u9646\u5987\u79d1\u80bf\u7624\u533b\u751f\u6240\u4e3b\u5bfc\u7684\u4e34\u5e8a\u6210\u679c<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"color: rgb(214, 214, 214);font-size: 12px;\">doi\uff1a10.1016\/S1470-2045(18)30349-8<\/span><br  \/><\/p>\n<p style=\"padding-left: 1em;padding-right: 1em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u9ec4\u6b23\u3001\u84dd\u6625\u71d5\u6559\u6388\u56e2\u961f\u6700\u65b0\u5375\u5de2\u764c\u7814\u7a76\u6210\u679c\u8fd1\u65e5\u4e8e\u300a<\/span><em><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">Lancet Oncology<\/span><\/strong><\/em><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u300b\uff08\u67f3\u53f6\u5200\u00b7\u80bf\u7624\uff09\u5728\u7ebf\u53d1\u8868\u3002<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u8fd9\u4e5f\u662f\u81ea\u56fd\u9645\u533b\u5b66\u754c\u9876\u7ea7\u80bf\u7624\u5b66\u6742\u5fd7\u300a<\/span><em><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">Lancet Oncology<\/span><\/strong><\/em><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u300b\u521b\u520a\u4ee5\u6765\uff0c\u9996\u6b21\u7531\u4e2d\u56fd\u5927\u9646\u5987<\/span><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u79d1\u80bf\u7624\u533b\u751f\u6240\u4e3b\u5bfc\u7684\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u5728\u8be5\u6742\u5fd7\u53d1\u8868\u3002<\/span><\/p>\n<p style=\"padding-left: 1em;padding-right: 1em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u5375\u5de2\u764c\u662f\u6700\u5e38\u89c1\u7684\u5987\u79d1\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c\u5176\u6b7b\u4ea1\u7387\u4e00\u76f4\u9ad8\u5c45\u5987\u79d1\u6076\u6027\u80bf\u7624\u7684\u9996\u4f4d\u3002<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">2015\u5e74<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\uff0c\u4e2d\u56fd\u7ea6\u6709<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">52\uff0c100\u4f8b<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u65b0\u53d1\u75c5\u4f8b\uff0c\u7ea6\u6709<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">22\uff0c500<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u540d\u60a3\u8005\u56e0\u6b64\u6b7b\u4ea1\u3002<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">\u8d85\u8fc770%<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u7684\u60a3\u8005\u5728\u5c31\u8bca\u65f6\u5df2\u4e3a\u75be\u75c5\u665a\u671f\u3002<\/span><\/p>\n<p style=\"padding-left: 1em;padding-right: 1em;\"><br  \/><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u76ee\u524d\uff0c\u665a\u671f\u5375\u5de2\u764c\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u5f0f\u4e3b\u8981\u5305\u62ec\u5375\u5de2\u764c\u5168\u9762\u5206\u671f\u672f\/\u80bf\u7624\u7ec6\u80de\u51cf\u706d\u672f\uff0c\u4ee5\u53ca\u672f\u540e\u4ee5\u94c2\u4e3a\u57fa\u7840\u7684\u4e00\u7ebf\u5316\u7597\u3002<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u5c3d\u7ba1<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">20\u5e74<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u591a\u6765\uff0c\u968f\u7740\u5916\u79d1\u624b\u672f\u6280\u80fd\u7684\u63d0\u5347\uff0c\u4ee5\u53ca\u7d2b\u6749\u9187\u7c7b\u3001\u94c2\u7c7b\u548c\u4f17\u591a\u4e8c\u7ebf\u5316\u7597\u836f\u7269\u7684\u4e34\u5e8a\u5e94\u7528\uff0c\u5375\u5de2\u764c\u60a3\u8005\u7684\u9884\u540e\u5f97\u5230\u4e86\u660e\u663e\u7684\u6539\u5584\uff0c\u4f46\u665a\u671f\u60a3\u8005\u7684<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">5\u5e74\u751f\u5b58\u7387\u4ecd\u7136\u4e0d\u8db330%<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u3002\u5927\u90e8\u5206\u665a\u671f\u60a3\u8005\u5728\u5b8c\u6210\u4e86\u6807\u51c6\u7684\u6cbb\u7597\u540e\u6700\u7ec8\u51fa\u73b0\u75be\u75c5\u590d\u53d1\u3002<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;padding-left: 1em;padding-right: 1em;letter-spacing: 1px;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4e34\u5e8a\u4e0a\uff0c\u6839\u636e\u60a3\u8005\u63a5\u53d7\u542b\u94c2\u65b9\u6848\u7684\u5316\u7597\u540e\u51fa\u73b0\u590d\u53d1\u7684\u65f6\u95f4\u4e0d\u540c\uff0c\u5316\u7597\u7ed3\u675f<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">6\u4e2a\u6708<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4ee5\u540e\u51fa\u73b0\u7684\u590d\u53d1\u4e3a\u94c2\u654f\u611f\u578b\u590d\u53d1\uff1b\u5316\u7597\u7ed3\u675f<\/span><strong><span style=\"font-size: 16px;color: rgb(24, 114, 186);\">6\u4e2a\u6708<\/span><\/strong><span style=\"font-size: 16px;color: rgb(76, 76, 76);\">\u4ee5\u5185\u590d\u53d1\u7684\u5219\u4e3a\u94c2\u8010\u836f\u578b\u590d\u53d1\u3002<\/span><\/p>\n<\/p>\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u6587\u7cfb\u751f\u7269\u8c37\u539f\u521b\u7f16\u8bd1\uff0c\u6b22\u8fce\u5206\u4eab\uff0c\u8f6c\u8f7d\u987b\u6388\u6743\uff01 &nbsp;\u8c37 \u541b \u8bf4&nbsp; 6\u6708~8\u6708\u6211\u56fd\u79d1\u5b66\u5bb6\u53d1\u8868\u7684\u90e8 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":43695,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/43694"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=43694"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/43694\/revisions"}],"predecessor-version":[{"id":43703,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/43694\/revisions\/43703"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/43695"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=43694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=43694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=43694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}