{"id":4373,"date":"2018-07-06T01:00:00","date_gmt":"2018-07-27T06:52:18","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/1953-2018%ef%bc%8c%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e7%96%97%e6%b3%95%e7%9a%84%e7%be%a4%e6%98%9f%e9%97%aa%e8%80%80%e6%97%b6%ef%bc%88%e4%b8%8a%e7%af%87%ef%bc%89\/"},"modified":"2018-07-27T14:52:24","modified_gmt":"2018-07-27T06:52:24","slug":"1953-2018%ef%bc%8c%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e7%96%97%e6%b3%95%e7%9a%84%e7%be%a4%e6%98%9f%e9%97%aa%e8%80%80%e6%97%b6%ef%bc%88%e4%b8%8a%e7%af%87%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/4373\/","title":{"rendered":"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\"><span style=\"max-width: 100%;\">\u70b9\u51fb\u4e0a\u65b9\u7684<\/span><span style=\"max-width: 100%;\">&nbsp;\u884c\u821fDrug&nbsp;<span style=\"max-width: 100%;color: rgb(127, 127, 127);\">\u25b2<\/span><span style=\"max-width: 100%;color: rgb(127, 127, 127);\">&nbsp;\u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5eb7\u5fb7\/<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7f16\u8bd1\uff08\u6765\u6e90\uff1aCRI\uff09<\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/strong><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br  \/><\/p>\n<p style=\"padding: 20px 8px 15px;max-width: 100%;min-height: 1em;\"><strong style=\"max-width: 100%;font-size: 1em;line-height: 1.5em;text-decoration: inherit;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-size: 12px;line-height: 1.5em;text-decoration: inherit;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7f16\u8005\u6309\uff1a<\/span><\/strong><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-size: 12px;text-decoration: inherit;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f4d\u4e8e\u7ebd\u7ea6\u7684\u764c\u75c7\u7814\u7a76\u6240\uff08Cancer Research Institute\uff0cCRI\uff09\u6210\u7acb\u4e8e1953\u5e74\uff0c\u662f\u5168\u7403\u764c\u75c7\u514d\u75ab\u5b66\u7684\u9886\u5148\u673a\u6784\u3002\u4eca\u5e746\u6708\u4efd\uff0c\u5728\u6210\u7acb65\u5468\u5e74\u4e4b\u9645\uff0cCRI\u516c\u5e03\u4e8630\u9879\u5176\u8d44\u52a9\u7684\u91cd\u8981\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u79d1\u5b66\u7a81\u7834\uff0c\u5b83\u4eec\u5305\u62ec\uff1a1)\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7684\u57fa\u7840\uff1b2)\u7406\u89e3\u514d\u75ab\u68c0\u67e5\u70b9\u548c\u901a\u8def\uff1b3)\u6297\u764c\u7684\u514d\u75ab\u7ec6\u80de\uff1b4)<span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5bf9\u6297\u764c\u75c7\u7684<\/span>\u7ec6\u83cc\u548c\u75ab\u82d7\u3002\u836f\u660e\u5eb7\u5fb7\u7f16\u8bd1\u6574\u7406\u4e86\u8fd930\u4e2a\u7a81\u7834\u6027\u6210\u679c\uff0c\u5206\u4e3a\u4e0a\u4e0b\u4e24\u7bc7\u4e0e\u5927\u5bb6\u4e00\u540c\u5206\u4eab\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">PART1\uff1a<\/span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7684\u57fa\u7840<\/span><\/span><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;background-color: rgb(0, 112, 192);height: 1px;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">1\uff0e1976\u5e74\uff1aHiroshi Shiku\u535a\u58eb\uff0cHerbert Oettgen\u535a\u58eb\u548cLloyd Old\u535a\u58eb<\/span><\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532674339.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u572820\u4e16\u7eaa70\u5e74\u4ee3\uff0c\u5f88\u5c11\u6709\u4eba\u76f8\u4fe1\u514d\u75ab\u7cfb\u7edf\u5bf9\u764c\u75c7\u6709\u4fdd\u62a4\u80fd\u529b\u3002\u5e78\u8fd0\u7684\u662f\uff0cHirsohi Shiku\u535a\u58eb\uff0cHerbert Oettegen\u535a\u58eb\u548cLloyd J. Old\u535a\u58eb<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5e2e\u52a9\u8bc1\u660e\u4e86\u514d\u75ab\u7cfb\u7edf\u786e\u5b9e\u5728\u4fdd\u62a4\u4eba\u4f53\u62b5\u5fa1\u764c\u75c7\u65b9\u9762\u53d1\u6325\u4e86\u4f5c\u7528\u3002<\/strong>\u4f4d\u4e8e\u7eaa\u5ff5\u65af\u9686-\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\uff08Memorial Sloan Kettering Cancer Center\uff09\u7684\u8fd9\u4e9b\u79d1\u5b66\u5bb6\u4eec\u8868\u660e\uff0c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u8840\u6db2\u4e2d\u7684\u6297\u4f53\uff0c\u53ef\u4ee5\u8bc6\u522b\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u4e0a\u7684\u6297\u539f\u5e76\u4e0e\u4e4b\u53cd\u5e94\uff0c\u8fd9\u4e9b\u6297\u539f\u4e5f\u80fd\u591f\u8868\u5f81\u3002\u8fd9\u662f\u514d\u75ab\u7cfb\u7edf\u80fd\u591f\u7cbe\u786e\u7784\u51c6\u764c\u7ec6\u80de\u5e76\u5bf9\u5176\u53d1\u8d77\u53cd\u5e94\u7684\u9996\u8981\u5173\u952e\u8bc1\u636e\u4e4b\u4e00\uff0c\u5e76\u4e14\u6709\u52a9\u4e8e\u5efa\u7acb\u764c\u75c7\u514d\u75ab\u5b66\u548c\u514d\u75ab\u6cbb\u7597\u7684\u6982\u5ff5\u57fa\u7840\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">2\uff0e1979\u5e74\uff1aJohn Pesando\u535a\u58eb\u548cStuart Schlossman\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532674339.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6211\u4eec\u7684\u514d\u75ab\u7ec6\u80de\u4ea7\u751f\u7684\u6297\u4f53\u4f7f\u5f97\u514d\u75ab\u7cfb\u7edf\u80fd\u591f\u81ea\u7136\u5730\u9776\u5411\u764c\u75c7\uff0c\u4f46\u662f\u6297\u4f53\u4e5f\u53ef\u4ee5\u7528\u4e8e\u5404\u79cd\u5176\u4ed6\u76ee\u7684\u3002\u572820\u4e16\u7eaa70\u5e74\u4ee3\uff0c\u6297\u4f53\u751f\u4ea7\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\uff0c\u8fd9\u4f7f\u5f97\u79d1\u5b66\u5bb6\u80fd\u591f\u4e3a\u5404\u79cd\u5e94\u7528\u5b9a\u5236\u9776\u5411\u6297\u4f53\uff0c\u5e76\u4f7f\u8fd9\u4e9b\u7cbe\u786e\u9776\u5411\u86cb\u767d\u80fd\u591f\u7528\u4e8e\u8bb8\u591a\u4e0d\u540c\u751f\u7269\u8fc7\u7a0b\u7684\u7814\u7a76\uff0c\u5c24\u5176\u662f\u5728\u76f8\u5bf9\u8f83\u65b0\u5174\u7684\u514d\u75ab\u5b66\u9886\u57df\u3002\u5728\u8fd9\u4e2a\u9879\u76ee\u4e2d\uff0c Fred Hutchinson\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u7684John Pesando\u535a\u58eb\u548cStuart Schlossman\u535a\u58eb\u521b\u5efa\u4e86\u6297\u4f53\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7528\u4e8e\u9776\u5411\u5728\u6fc0\u6d3b\u7684\u4eba\u7c7bT\u7ec6\u80de\u4e0a\u53d1\u73b0\u76841a\u6297\u539f\uff0c<\/strong>\u5e76\u4f7f\u4ed6\u4eec\u80fd\u591f\u5728T\u7ec6\u80de\u751f\u7269\u5b66\u80cc\u666f\u4e0b\u8868\u5f81\u8fd9\u4e9b\u91cd\u8981\u7684\u6807\u5fd7\u7269\u3002\uff08\u5728\u540c\u4e00\u5e74\uff0c\u4ed6\u4eec\u8fd8\u5728CRI\u7684\u8d44\u52a9\u4e0b\uff0c\u5f00\u53d1\u4e86\u5176\u4ed6\u5b9a\u5236\u6297\u4f53\uff0c\u53ef\u4ee5\u9776\u5411\u767d\u8840\u75c5\u7ec6\u80de\u4e0a\u7684\u7279\u5b9a\u6297\u539f\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">3. 1981\u5e74\uff1aWolfgang Dippold\u535a\u58eb\u548cLloyd J. Old\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532674340.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u5b9e\u9a8c\u5ba4\u91cc\uff0c\u6297\u4f53\u4e5f\u53ef\u7528\u4e8e\u7814\u7a76\u7ec6\u80de\u5185\u7ec4\u5206\u3002Wolfgang Dippold\u535a\u58eb\u548cLloyd J. Old\u535a\u58eb\u5f00\u53d1\u51fa\u4e00\u79cd\u68c0\u6d4bp53\u7684\u6297\u4f53\u3002p53\u662f\u4e00\u79cd\u91cd\u8981\u7684\u80bf\u7624\u6291\u5236\u86cb\u767d\uff0c\u9632\u6b62\u7ec6\u80de\u8fc7\u5ea6\u548c\u4e0d\u9002\u5f53\u7684\u589e\u6b96\u3002\u6211\u4eec\u73b0\u5728\u77e5\u9053p53\u5728\u5404\u79cd\u6076\u6027\u80bf\u7624\u4e2d\u7ecf\u5e38\u53d1\u751f\u7a81\u53d8\uff0c\u4e0d\u53d7\u9650\u5236\u7684\u751f\u957f\u3002\u5f53\u65f6\uff0c\u5bf9\u4e8e\u8fd9\u79cd\u91cd\u8981\u86cb\u767d\u8d28\u7684\u6240\u6709\u4e86\u89e3\u90fd\u662f\u5b83\u5b58\u5728\u4e8e\u5404\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u9664\u4e86\u5f00\u53d1\u8fd9\u79cdp53\u9776\u5411\u6297\u4f53\u4e4b\u5916\uff0c\u8fd9\u9879\u5de5\u4f5c\u6700\u91cd\u8981\u7684\u8d21\u732e\u4e4b\u4e00\u662f\u663e\u793ap53\u5b58\u5728\u4e8e\u7ec6\u80de\u6838\u4e2d\uff0c\u5728\u7ec6\u80de\u6838\u4e2d\u53d1\u6325\u5176\u5bf9\u7ec6\u80de\u751f\u957f\u7684\u63a7\u5236\u3002<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">4. 1983\u5e74\uff1aSusumu Tonegawa\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress9-1532674340.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6211\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u5982\u4f55\u80fd\u591f\u521b\u5efa\u6240\u6709\u4e0d\u540c\u7684\u6297\u4f53\uff0c\u9776\u5411\u8fd9\u4e9b\u4e0d\u540c\u7684\u7ec6\u80de\uff1f\u572820\u4e16\u7eaa70\u5e74\u4ee3\u672b\u548c80\u5e74\u4ee3\u521d\uff0c\u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff08Massachusetts Institute of Technology\uff09\u7684Susumu Tonegawa\u535a\u58eb\u56e2\u961f\u7834\u8bd1\u4e86\u8fd9\u4e2a\u8c1c\u56e2\uff0c\u5e76\u4e8e1983\u5e74\u63ed\u793a\u4e86\u8fd9\u4e2a\u8c1c\u56e2\u7684\u89e3\u51b3\u65b9\u6848\u3002\u6211\u4eec\u514d\u75ab\u7cfb\u7edf\u7684B\u7ec6\u80de\u62e5\u6709\u4ece\u6700\u5f00\u59cb\u4ea7\u751f\u5404\u79cd\u6297\u4f53\u7684\u57fa\u56e0\uff0c\u4f46\u5b83\u4eec\u5728\u6210\u719f\u65f6\u6240\u505a\u7684\u662f\u2014\u2014\u53ef\u4ee5\u91cd\u65b0\u6392\u5217\u548c\u91cd\u7ec4\u7f16\u7801\u4e0d\u540c\u6297\u4f53\u7ec4\u5206\u7684DNA\uff0c\u5e76\u4fee\u8865\u6297\u4f53\u7684\u8bbe\u8ba1\u3002\u901a\u8fc7\u8fd9\u4e00\u8fc7\u7a0b\uff0c\u514d\u75ab\u7cfb\u7edf\u7684B\u7ec6\u80de\u53ef\u4ee5\u5171\u540c\u5236\u9020\u6570\u4ee5\u4e07\u4ebf\u8ba1\u4e0d\u540c\u7c7b\u578b\u7684\u6297\u4f53\uff0c\u786e\u4fdd\u5b83\u4eec\u80fd\u591f\u9488\u5bf9\u51e0\u4e4e\u65e0\u9650\u79cd\u7c7b\u7684\u5a01\u80c1\uff0c\u5305\u62ec\u80bf\u7624\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5bf9\u4e8e\u8fd9\u4e00\u53d1\u73b0\uff0cTonegawa\u535a\u58eb\u88ab\u6388\u4e881987\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">5. 2000\u5e74\uff1aTerri Towers\u535a\u58eb\u548cJeffrey Ravetch\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532674340.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u867d\u7136\u4e0e\u5a01\u80c1\u8868\u9762\u7ed3\u5408\u7684\u6297\u4f53\uff08\u75c5\u6bd2\uff0c\u7ec6\u83cc\u6216\u764c\u75c7\uff09\u7684\u201c\u524d\u7aef\u201d\uff08\u9776\u5411\u6216\u53ef\u53d8\u533a\uff09\u901a\u5e38\u88ab\u8ba4\u4e3a\u662f\u6297\u4f53\u7684\u6700\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u6d1b\u514b\u83f2\u52d2\u5927\u5b66\uff08The Rockefeller University\uff09\u7684Terri Towers\u535a\u58eb\u548cJeffrey Ravetch\u535a\u58eb\u8868\u660e\uff0c\u201c\u540e\u7aef\u201d\uff08\u6216\u6052\u5b9a\u533a\uff09\u5bf9\u4e8e\u9776\u5411\u6297\u4f53\u7684\u6297\u80bf\u7624\u6d3b\u6027\u4e5f\u5f88\u91cd\u8981\u3002\u4e00\u65e6\u6297\u4f53\u7684\u201c\u524d\u7aef\u201d\u4e0e\u9776\u6807\u7ed3\u5408\uff0c\u5176\u201c\u540e\u7aef\u201d\u5c31\u53ef\u4ee5\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u4e0a\u7684Fc\u53d7\u4f53\uff08FcR\uff09\u7ed3\u5408\uff0c\u5e76\u544a\u8bc9\u5b83\u4eec\u5e94\u8be5\u5982\u4f55\u4e0e\u6297\u4f53\u7ed3\u5408\u7684\u5b9e\u4f53\u53cd\u5e94\u3002\u7814\u7a76\u4e0e\u6297\u4f53\u7ed3\u5408\u7684\u764c\u7ec6\u80de\uff0c\u8fd9\u9879\u5de5\u4f5c\u8868\u660e\uff0c\u6297\u4f53\u7684\u540e\u7aef\u5fc5\u987b\u4e0e\u6fc0\u6d3b\u7684FcR\u7ed3\u5408\uff0c\u4ee5\u4fbf\u901a\u8fc7\u79f0\u4e3a\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\u6216ADCC\u7684\u8fc7\u7a0b\u4fc3\u8fdb\u764c\u7ec6\u80de\u7684\u7834\u574f\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u4e2a\u53d1\u73b0\u4f7f\u6211\u4eec\u80fd\u591f\u63d0\u9ad8\u9776\u5411\u6297\u4f53\u7684\u6297\u764c\u6d3b\u6027\uff0c\u76ee\u524d\u6709\u8d85\u8fc720\u79cd\u6297\u4f53\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u3002<\/strong>\u6700\u8fd1\uff0cRavetch\u535a\u58eb\u548cCRI\u535a\u58eb\u540e\u7814\u7a76\u5458Rony Dahan\u535a\u58eb\u4e5f\u63ed\u793a\u4e86\u68c0\u67e5\u70b9\u514d\u75ab\u6cbb\u7597\u4e2d\u6297\u4f53-FcR\u7ed3\u5408\u7684\u91cd\u8981\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">6. 1987\u5e74\uff1aMarcia Blackman\u535a\u58eb\u548cPhilippa Marrack\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532674341.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e0a\u9762\u51e0\u4e2a\u6210\u679c\u4e3b\u8981\u96c6\u4e2d\u5728B\u7ec6\u80de\u4ea7\u751f\u7684\u6297\u4f53\u4e0a\u3002\u73b0\u5728\uff0c\u6211\u4eec\u5c06\u6ce8\u610f\u529b\u8f6c\u5411\u514d\u75ab\u7cfb\u7edf\u4e2d\u6700\u91cd\u8981\u7684\u201c\u58eb\u5175\u201d\uff1aT\u7ec6\u80de\u3002\u867d\u7136B\u7ec6\u80de\u4ee5\u6297\u4f53\u7684\u5f62\u5f0f\u4ea7\u751f\u201c\u5f52\u5de2\u5bfc\u5f39\u201d\uff0c\u5bfb\u627e\u80fd\u4e0e\u4e4b\u7ed3\u5408\u7684\u5a01\u80c1\uff0c\u4f46T\u7ec6\u80de\u4f1a\u76f4\u63a5\u8fdb\u5165\u5a01\u80c1\u672c\u8eab\uff0c\u7279\u522b\u662f\u901a\u8fc7T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u3002\u5728\u67d0\u79cd\u7a0b\u5ea6\u4e0a\uff0c\u9274\u4e8eTCR\u4ecd\u7136\u4f9d\u9644\u4e8e\u6d3b\u7ec6\u80de\u5e76\u5f71\u54cd\u5176\u6d3b\u6027\uff0c\u56e0\u6b64\u89e3\u5f00TCR\u7684\u5965\u79d8\u9700\u8981\u6bd4\u6297\u4f53\u7684\u65f6\u95f4\u66f4\u957f\u3002\u6297\u4f53\u80fd\u591f\u76f4\u63a5\u5728\u7ec6\u80de\u8868\u9762\u7ed3\u5408\u5206\u5b50\u2014\u2014\u4efb\u4f55\u5206\u5b50\u3002\u5b9e\u9645\u4e0a\uff0cT\u7ec6\u80de\u7684TCR\u5fc5\u987b\u5728\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269\uff08MHC\uff09\u5b58\u5728\u4e0b\u4e0e\u7279\u5b9a\u9776\u70b9\u76f8\u4e92\u4f5c\u7528\uff0cMHC\u8d1f\u8d23\u5c06\u9776\u70b9\uff08\u79f0\u4e3a\u6297\u539f\uff09\u5448\u9012\u7ed9T\u7ec6\u80de\u3002\u6709\u4e24\u79cd\u7c7b\u578b\u7684MHC\uff0cI\u7c7b\u548cII\u7c7b\uff0c\u5b83\u4eec\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u6559\u80b2T\u7ec6\u80de\u8ba4\u8bc6\uff0c\u9776\u5411\u548c\u6467\u6bc1\u5a01\u80c1\u3002\u8fd9\u4e9bTCR-MHC\u76f8\u4e92\u4f5c\u7528\u662f\u6211\u4eec\u5f3a\u5927\u7684\u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\u7684\u6838\u5fc3\uff0c\u79d1\u7f57\u62c9\u591a\u5927\u5b66\uff08University of Colorado\uff09\u548c\u56fd\u5bb6\u72b9\u592a\u533b\u5b66\u548c\u7814\u7a76\u4e2d\u5fc3\uff08National Jewish Medical and Research Center\uff09\u7684Marcia Blackman\u535a\u58eb\u548cPhilippa Marrack\u535a\u58eb\u7684\u7814\u7a76\u7a81\u7834\u786e\u5207\u5730\u63ed\u793a\u4e86TCR\u548cII\u7c7bMHC\u7684\u54ea\u4e9b\u7ec4\u5206\u5f7c\u6b64\u7ed3\u5408\u4ee5\u4fc3\u8fdb\u8f85\u52a9\uff08CD4+\uff09T\u7ec6\u80de\u7684\u6d3b\u6027\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u4e00\u7a81\u7834\u662f\u4e00\u9879\u91cd\u8981\u8d21\u732e\uff0c\u4e3a\u76ee\u524d\u4e34\u5e8a\u4e0a\u7684\u8bb8\u591aT\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u94fa\u5e73\u4e86\u9053\u8def\u3002<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">7. 1983\uff1aJonathan Austyn\u535a\u58eb\u548cRalph Steinman\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress2-1532674341.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u83b7\u5f97\u6027\u514d\u75ab\u5e94\u7b54\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u7684\u53e6\u4e00\u7ec4\u514d\u75ab\u7ec6\u80de\u662f\u6811\u7a81\uff08DC\uff09\u7ec6\u80de\uff0c\u56e0\u5176\u201c\u6811\u7a81\u201d\u6216\u201c\u6811\u72b6\u201d\u7684\u624b\u81c2\u800c\u5f97\u540d\uff0c\u8fd9\u4e9b\u624b\u81c2\u4f7fDC\u7ec6\u80de\u80fd\u591f\u63a5\u89e6\u5e76\u4e0e\u5404\u79cd\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u3002\u867d\u7136\u6811\u7a81\u72b6\u7ec6\u80de\u4e0d\u76f4\u63a5\u653b\u51fb\u80bf\u7624\uff0c\u4f46\u5b83\u4eec\u5728\u534f\u8c03\u6574\u4f53\u514d\u75ab\u53cd\u5e94\u65b9\u9762\u53d1\u6325\u7740\u6838\u5fc3\u4f5c\u7528\uff0c\u901a\u8fc7\u6559\u80b2T\u7ec6\u80de\u4e86\u89e3\u764c\u7ec6\u80de\u7684\u5916\u89c2\uff0c\u4f7fT\u7ec6\u80de\u53ef\u4ee5\u6467\u6bc1\u764c\u7ec6\u80de\u3002Ralph Steinman\u535a\u58eb\u662f\u8be5\u9886\u57df\u6700\u91cd\u8981\u7684\u5148\u9a71\u4e4b\u4e00\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4ed6\u53d1\u73b0\u4e86\u6811\u7a81\u72b6\u7ec6\u80de\uff08\u8be5\u9879\u7a81\u7834\u4f7f\u4ed6\u83b7\u5f972011\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\uff09\uff0c\u5e76\u4e14\u63cf\u8ff0\u6811\u7a81\u72b6\u7ec6\u80de\u8bb8\u591a\u7279\u5f81<\/strong>\u3002\u5728\u8fd9\u9879\u5de5\u4f5c\u4e2d\uff0c\u4ed6\u63ed\u793a\u4e86\u6811\u7a81\u72b6\u7ec6\u80de\u4fc3\u8fdbT\u7ec6\u80de\u751f\u957f\u548c\u523a\u6fc0\u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\u7684\u80fd\u529b\u3002\u7531\u4e8e\u8fd9\u4e00\u91cd\u8981\u53d1\u73b0\uff0c FDA\u5df2\u7ecf\u6279\u51c6\u4e86\u4e00\u79cd\u6811\u7a81\u72b6\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff0c\u5176\u4ed6\u51e0\u79cd\u514d\u75ab\u7597\u6cd5\u76ee\u524d\u6b63\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u4f30\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">8. 2001\u5e74\uff1aVijay Shankaran\u535a\u58eb\uff0cAllen Bruce\u535a\u58eb\uff0cHiroki Ikeda\u535a\u58eb\u548cRobert Schreiber\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532674342.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">20\u4e16\u7eaa70\u5e74\u4ee3\u8fdb\u884c\u4e86\u4e00\u9879\u5b9e\u9a8c\uff0c\u4f3c\u4e4e\u4e00\u52b3\u6c38\u9038\u5730\u7ec8\u7ed3\u4e86\u4e89\u8bba\u2014\u2014\u201c\u8bc1\u660e\u201d\u514d\u75ab\u7cfb\u7edf\u4e0d\u80fd\u4fdd\u62a4\u6211\u4eec\u514d\u53d7\u764c\u75c7\u7684\u4fb5\u5bb3\u3002\u5e78\u8fd0\u7684\u662f\uff0c\u521a\u521a\u5b8c\u6210\u535a\u58eb\u5b66\u4f4dRobert Schreiber\u535a\u58eb\u5e76\u4e0d\u5b8c\u5168\u76f8\u4fe1\u3002\u51e0\u5341\u5e74\u540e\u768420\u4e16\u7eaa90\u5e74\u4ee3\u540e\u671f\uff0c\u4ed6\u548c\u4ed6\u7684\u5b9e\u9a8c\u5ba4\u6210\u5458\u900f\u9732\uff0c\u4e0d\u4ec5\u514d\u75ab\u7cfb\u7edf\u53ef\u4ee5\u901a\u8fc7\u201c\u514d\u75ab\u76d1\u89c6\u201d\u5929\u7136\u5730\u9632\u6b62\u80bf\u7624\u7684\u5f62\u6210\uff0c\u800c\u4e14\u764c\u75c7\u4e0e\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u7684\u5173\u7cfb\u4e5f\u6bd4\u5f88\u591a\u4eba\u8ba4\u4e3a\u7684\u8981\u66f4\u590d\u6742\u3002\u901a\u8fc7\u4e00\u4e2a\u540d\u4e3a\u201cImmunoediting\u201d\u7684\u8fc7\u7a0b\u2014\u2014\u4ed6\u53d1\u73b0\u3001\u63cf\u8ff0\u5e76\u521b\u9020\u4e86\u8fd9\u4e00\u8fc7\u7a0b\u2014\u2014\u4ed6\u5728\u5c0f\u9f20\u8eab\u4e0a\u8bc1\u660e\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5f53\u514d\u75ab\u7cfb\u7edf\u6d88\u706d\u4e86\u4e00\u4e9b\u80bf\u7624\u7ec6\u80de\uff0c\u5b83\u4e5f\u4f1a\u6539\u9020\u6216\u7f16\u8f91\u5269\u4f59\u7684\u80bf\u7624\u7ec6\u80de\u7fa4\uff0c\u4f7f\u5b83\u4eec\u53d8\u5f97\u80fd\u591f\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u4fa6\u67e5\u3002<\/strong>\u901a\u8fc7\u5c55\u793a\u8fd9\u4e9b\u201c\u6e38\u620f\u89c4\u5219\u201d\uff0cSchreiber\u535a\u58eb\u548c\u4ed6\u7684\u540c\u4e8b\u5927\u5927\u6269\u5c55\u4e86\u6211\u4eec\u5bf9\u764c\u75c7\u548c\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u5173\u7cfb\u7684\u7406\u89e3\u3002\u7531\u4e8e\u8fd9\u4e00\u53d1\u73b0\u8fdc\u8fdc\u9886\u5148\u4e8e\u5176\u65f6\u4ee3\uff0c\u5176\u5f71\u54cd\u9700\u8981\u4e00\u6bb5\u65f6\u95f4\u624d\u80fd\u8ba9\u8be5\u9886\u57df\u7684\u8bb8\u591a\u4eba\u7406\u89e3\uff0c\u4f46\u5e78\u8fd0\u7684\u662f\uff0c\u8fd9\u4e9b\u89c1\u89e3\u540e\u6765\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u5f97\u5230\u9a8c\u8bc1\uff0c\u73b0\u5728\u6b63\u88ab\u7528\u4e8e\u5f00\u53d1\u66f4\u6709\u6548\u7684\u764c\u75c7\u7597\u6cd5\uff0c\u7279\u522b\u662f\u8ba4\u8bc6\u5230\u764c\u75c7\u53ef\u4ee5\u9003\u907f\u514d\u75ab\u53cd\u5e94\u5e76\u5bf9\u514d\u75ab\u7597\u6cd5\u4ea7\u751f\u6297\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">9. 2014\u5e74\uff1aAntoni Ribas\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532674342.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u8fc7\u53bb\u768465\u5e74\u91cc\uff0c\u4e3a\u4e86\u66f4\u597d\u5730\u7406\u89e3\u764c\u75c7\u4e0e\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u8bb8\u591a\u7814\u7a76\u90fd\u662f\u7784\u51c6\u552f\u4e00\u76ee\u6807\uff1a\u5229\u7528\u514d\u75ab\u7cfb\u7edf\u7684\u529b\u91cf\u6765\u6cbb\u7597\u4eba\u7c7b\u7684\u764c\u75c7\u3002\u968f\u77402011\u5e74\u7b2c\u4e00\u4e2a\u68c0\u67e5\u70b9\u514d\u75ab\u7597\u6cd5\u7684\u6279\u51c6\uff0c\u4ee5\u53ca2014\u5e74\u53e6\u5916\u4e24\u4e2a\u7597\u6cd5\u7684\u83b7\u6279\uff0c\u8fd9\u4e9b\u68a6\u60f3\u5f00\u59cb\u4ee5\u91cd\u8981\u7684\u65b9\u5f0f\u5b9e\u73b0\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u7edd\u4e0d\u662f\u6cbb\u6108\u2014\u2014\u81f3\u5c11\u5bf9\u7edd\u5927\u591a\u6570\u60a3\u8005\u800c\u8a00\u2014\u2014\u56e0\u6b64\u6211\u4eec\u9700\u8981\u7ee7\u7eed\u8fdb\u884c\u57fa\u7840\u7814\u7a76\uff0c\u4f7f\u6211\u4eec\u80fd\u591f\u8d8a\u6765\u8d8a\u591a\u5730\u4e86\u89e3\u764c\u75c7\u548c\u514d\u75ab\u7cfb\u7edf\uff0c\u4ee5\u53ca\u7279\u5b9a\u7684\u514d\u75ab\u7597\u6cd5\u5982\u4f55\u5de5\u4f5c\uff0c\u4e5f\u8ba9\u6211\u4eec\u53ef\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u4e3a\u60a3\u8005\u5e26\u6765\u597d\u5904\u3002\u4e3a\u6b64\uff0c\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\uff08UCLA\uff09\u7684Antoni Ribas\u535a\u58eb\u63d0\u4f9b\u4e86\u975e\u5e38\u91cd\u8981\u7684\u89c1\u89e3\uff0c\u8bf4\u660e\u4e86\u4e3a\u4ec0\u4e48\u67d0\u4e9b\u60a3\u8005\u4ece\u514d\u75ab\u7597\u6cd5\u4e2d\u53d7\u76ca\uff0c\u800c\u53e6\u4e00\u4e9b\u5219\u6ca1\u6709\u3002\u5728\u7528pembrolizumab\uff08\u4e00\u79cd\u6297PD-1\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff09\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u65f6\uff0cRibas\u535a\u58eb\u7684\u7814\u7a76\u5c0f\u7ec4\u63ed\u793a\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u88ab\u201c\u6740\u624b\u201dT\u7ec6\u80de\u8bc6\u522b\u5e76\u6e17\u900f\u7684\u80bf\u7624\u66f4\u6709\u53ef\u80fd\u5bf9\u8fd9\u79cd\u68c0\u67e5\u70b9\u514d\u75ab\u7597\u6cd5\u4f5c\u51fa\u53cd\u5e94\u3002\u8fd9\u662f\u7406\u89e3\u514d\u75ab\u7597\u6cd5\u83b7\u5f97\u6210\u529f\u7684\u539f\u56e0\u7684\u9996\u4e2a\u91cd\u5927\u8fdb\u5c55\u4e4b\u4e00\u3002<\/strong>\u73b0\u5728\uff0c\u533b\u751f\u6709\u529e\u6cd5\u786e\u5b9a\u54ea\u4e9b\u60a3\u8005\u6700\u6709\u53ef\u80fd\u4ece\u514d\u75ab\u7597\u6cd5\u4e2d\u53d7\u76ca\uff0c\u5e76\u53ef\u4ee5\u4f7f\u7528\u8fd9\u4e9b\u4fe1\u606f\u6765\u76f8\u5e94\u5730\u6307\u5bfc\u4ed6\u4eec\u7684\u6cbb\u7597\u51b3\u7b56\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">P<span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">ART2: \u7406\u89e3\u514d\u75ab\u68c0\u67e5\u70b9\u548c\u901a\u8def<\/span><\/span><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;background-color: rgb(0, 112, 192);height: 1px;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">10. 1995\u5e74\uff1a Frank Borriello\u535a\u58eb\u548cArlene Sharpe\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532674342.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">2011\u5e74\uff0c\u7531\u4e8e\u57283\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u9996\u6b21\u63d0\u9ad8\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u751f\u5b58\u7387\uff0cipilimumab\u6210\u4e3aFDA\u6279\u51c6\u7684\u7b2c\u4e00\u4e2a\u68c0\u67e5\u70b9\u514d\u75ab\u7597\u6cd5\u3002\u901a\u8fc7\u963b\u65ad\u5173\u95edT\u7ec6\u80de\u7684CTLA-4\u901a\u8def\uff0c\u60a3\u8005\u7684\u514d\u75ab\u7cfb\u7edf\u80fd\u591f\u5bf9\u80bf\u7624\u53d1\u8d77\u66f4\u5f3a\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u5e76\u4e14\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u53ef\u4ee5\u63d0\u4f9b\u957f\u671f\u76ca\u5904\uff0c\u751a\u81f3\u53ef\u4ee5\u6cbb\u6108\u3002\u867d\u7136CTLA-4\u662f\u57281987\u5e74\u88ab\u53d1\u73b0\u7684\uff0c\u4f46\u76f4\u523020\u4e16\u7eaa90\u5e74\u4ee3\uff0c\u5b83\u5728\u514d\u75ab\u7ec6\u80de\u884c\u4e3a\u4e2d\u7684\u4f5c\u7528\u624d\u88ab\u786e\u5b9a\u3002\u5e2e\u52a9\u5efa\u7acb\u6211\u4eec\u5bf9\u8fd9\u4e00\u91cd\u8981\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u7406\u89e3\u7684\u5173\u952e\u7814\u7a76\u4e4b\u4e00\u662f\u54c8\u4f5b\u533b\u5b66\u9662\u548c\u5e03\u83b1\u6839\u5987\u5973\u533b\u9662\u7684Arlene Sharpe\u535a\u58eb\uff0c\u5979\u4e0eFrank Borriello\u535a\u58eb\u4e00\u8d77\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u786e\u5207\u5730\u8bc1\u660e\u4e86CTLA-4\u662f\u4e00\u79cdT\u7ec6\u80de\u7684\u8d1f\u8c03\u63a7\u5f00\u5173 \u2014\u2014\u5239\u8f66\u3002<\/strong>\u4ed6\u4eec\u8bbe\u8ba1\u4e86CTLA-4\u53d7\u4f53\u7f3a\u9677\u7684\u5c0f\u9f20\uff0c\u53d1\u73b0\u5b83\u4eec\u4f1a\u51fa\u73b0\u653b\u51fb\u5065\u5eb7\u7ec4\u7ec7\u548c\u5668\u5b98\u7684\u5931\u63a7\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u4e00\u7a81\u7834\u6027\u7684\u89c1\u89e3\u5f00\u542f\u68c0\u67e5\u70b9\u514d\u75ab\u6cbb\u7597\u9886\u57df\uff0c\u540e\u7eed\u5176\u4ed6\u4eba\u8bc1\u660e\u963b\u65adCTLA-4\u53ef\u589e\u5f3a\u9488\u5bf9\u764c\u75c7\u7684\u514d\u75ab\u5e94\u7b54\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u76f4\u63a5\u5bfc\u81f4\u6297CTLA-4\u836f\u7269ipilimumab\u7684\u4e34\u5e8a\u5f00\u53d1\u3002<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">11. 2006\u5e74\uff1aE. John Wherry\u535a\u58eb, David Masopust\u535a\u58eb\u548cRafi Ahmed\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress2-1532674343.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5f53\u6211\u4eec\u7684\u8eab\u4f53\u68c0\u6d4b\u5230\u5165\u4fb5\u8005\u5e76\u4ea7\u751f\u514d\u75ab\u53cd\u5e94\u65f6\uff0c\u6211\u4eec\u7684\u5065\u5eb7\u7ec6\u80de\u8868\u9762\u4e0a\u4f1a\u8868\u8fbe\u4e00\u79cd\u540d\u4e3aPD-L1\u7684\u86cb\u767d\u8d28\uff0c\u53ef\u4ee5\u786e\u4fdd\u5b83\u4eec\u4e0d\u4f1a\u88ab\u8bef\u4f24\u3002\u5982\u679cT\u7ec6\u80de\u4e0e\u5065\u5eb7\u7ec6\u80de\u7ed3\u5408\uff0cPD-L1\u5c31\u4e0eT\u7ec6\u80de\u4e0a\u7684PD-1\u514d\u75ab\u68c0\u67e5\u70b9\u7ed3\u5408\uff0c\u4f5c\u4e3a\u5236\u52a8\u5668\u201c\u8017\u7aed\u201dT\u7ec6\u80de\uff0c\u4ece\u800c\u4ee5\u4f7f\u5065\u5eb7\u7ec6\u80de\u4e0d\u53d7\u514d\u75ab\u7cfb\u7edf\u653b\u51fb\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u75c5\u6bd2\u611f\u67d3\u7684\u7ec6\u80de\u751a\u81f3\u80bf\u7624\u7ec6\u80de\u4e5f\u53ef\u4ee5\u6b3a\u9a97\u514d\u75ab\u7cfb\u7edf\u5e76\u901a\u8fc7PD-1 \/ PD-L1\u68c0\u67e5\u70b9\u4fdd\u62a4\u81ea\u5df1\u3002\u5728\u57c3\u9ed8\u91cc\u5927\u5b66\u7684\u7814\u7a76\u4e2d\uff0cE. John Wherry\uff0cDavid Masopust\u548cRafi Ahmed\u535a\u58eb\u8868\u660e<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u901a\u8fc7\u963b\u65ad\u8fd9\u79cdPD-1\u53d7\u4f53\u7684\u6d3b\u6027\uff0c\u53ef\u4ee5\u6062\u590d\u201c\u8017\u7aed\u201dT\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u589e\u5f3a\u5b83\u4eec\u6d88\u9664\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u7684\u80fd\u529b\u3002<\/strong>\u968f\u540e\uff0c\u8fd9\u79cd\u65b9\u6cd5\u4e5f\u88ab\u8bc1\u660e\u53ef\u4ee5\u5bf9\u6297\u764c\u75c7\uff0c\u4fc3\u8fdb\u4e86\u8bb8\u591aPD-1 \/ PD-L1\u68c0\u67e5\u70b9\u514d\u75ab\u7597\u6cd5\u7684\u5f00\u53d1\uff0c\u5176\u4e2d\u591a\u79cd\u73b0\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5404\u79cd\u665a\u671f\u764c\u75c7\u3002\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6210\u4e3a\u552f\u4e00\u4e0d\u8bba\u764c\u75c7\u7c7b\u578b\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u53ea\u8981\u80bf\u7624\u5177\u6709\u4ee5\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI-hi\uff09\u4e3a\u7279\u5f81\u7684\u4e0d\u7a33\u5b9a\u57fa\u56e0\u7ec4\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">12. 2014\u5e74\uff1aMatthew Gubin\u535a\u58eb\u548cRobert Schreiber\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532674343.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e0a\u8ff0\u9488\u5bf9PD-1 \/ PD-L1\u548cCTLA-4\u901a\u8def\u7684\u68c0\u67e5\u70b9\u514d\u75ab\u7597\u6cd5\uff0c\u53ef\u4ee5\u9632\u6b62\u6297\u764cT\u7ec6\u80de\u88ab\u5173\u95ed\uff0c\u5e76\u4e14\u5bf9\u67d0\u4e9b\u7c7b\u578b\u7684\u665a\u671f\u764c\u75c7\u975e\u5e38\u6709\u6548\u3002\u5c3d\u7ba1\u53d6\u5f97\u4e86\u4e34\u5e8a\u6210\u529f\uff0c\u4f46\u8fd9\u4e9b\u514d\u75ab\u7ec6\u80de\u5982\u4f55\u6d88\u9664\u80bf\u7624\u7684\u5177\u4f53\u7ec6\u8282\u5c1a\u672a\u5f97\u77e5\u3002\u6b63\u5982Robert Schreiber\u535a\u58eb\u548cM<\/span><strong style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/strong><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">atthew Gubin\u535a\u58eb\u8868\u793a\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u4e9b\u68c0\u67e5\u70b9\u514d\u75ab\u7597\u6cd5\u4f7fT\u7ec6\u80de\u80fd\u591f\u9776\u5411\u7531\u7a81\u53d8\u5f15\u8d77\u7684\u5f02\u5e38\u80bf\u7624\u6807\u5fd7\u7269\uff08\u79f0\u4e3a\u65b0\u6297\u539f\uff09\uff0c\u5e76\u5c06\u764c\u7ec6\u80de\u4e0e\u6b63\u5e38\u7ec6\u80de\u533a\u5206\u5f00\u6765<\/strong>\u3002\u867d\u7136\u8fd9\u4e9b\u9776\u5411\u65b0\u6297\u539f\u7684T\u7ec6\u80de\u5728\u6cbb\u7597\u524d\u5c31\u5b58\u5728\uff0c\u4f46\u8fd9\u4e9b\u514d\u75ab\u7597\u6cd5\u80fd\u591f\u91cd\u65b0\u6fc0\u6d3b\u5b83\u4eec\u5e76\u4f7f\u5b83\u4eec\u80fd\u591f\u7ee7\u7eed\u5bf9\u6297\u80bf\u7624\u7ec6\u80de\u3002\u8fd9\u4e9b\u4e3a\u5f53\u524d\u514d\u75ab\u7597\u6cd5\u6709\u6548\u6027\u7684\u673a\u5236\u63d0\u51fa\u91cd\u8981\u89c1\u89e3\uff0c\u4e5f\u63d0\u51fa\u4e86\u53ef\u80fd\u6539\u5584\u514d\u75ab\u7597\u6cd5\u5e94\u7528\u5e76\u5c06\u5176\u76ca\u5904\u6269\u5c55\u5230\u66f4\u591a\u60a3\u8005\u7684\u7b56\u7565\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">13. 2016\u5e74\uff1aTon Schumacher\u535a\u58eb, Roger Lo\u535a\u58eb\u548c Antoni Ribas\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532674343.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u867d\u7136\u514d\u75ab\u7597\u6cd5\u6709\u53ef\u80fd\u5e2e\u52a9\u6240\u6709\u60a3\u8005\uff0c\u4f46\u76ee\u524d\u7684PD-1 \/ PD-L1\u68c0\u67e5\u70b9\u514d\u75ab\u7597\u6cd5\u4ecd\u7136\u53ea\u9002\u7528\u4e8e\u67d0\u4e9b\u60a3\u8005\u4e9a\u7ec4\u3002\u5728\u786e\u5b9a\u4e86\u4f7f\u60a3\u8005\u66f4\u6709\u53ef\u80fd\u5bf9\u68c0\u67e5\u70b9\u514d\u75ab\u6cbb\u7597\u4f5c\u51fa\u53cd\u5e94\u7684\u7279\u5f81\u540e\uff0c\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\uff08UCLA\uff09\u7684Antoni Ribas\u535a\u58eb\u3001\u8377\u5170\u764c\u75c7\u7814\u7a76\u6240\u7684Ton Schumacher\u535a\u58eb\u3001\u4ee5\u53ca\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7684Roger Lo\u535a\u58eb\u5171\u540c\u53d1\u73b0\u4e86\u67d0\u4e9b\u4e0e\u68c0\u67e5\u70b9\u514d\u75ab\u6cbb\u7597\u8010\u836f\u76f8\u5173\u7684\u7a81\u53d8\u3002\u7279\u522b\u662f\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4ed6\u4eec\u53d1\u73b0\u764c\u7ec6\u80de<em style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">JAK1<\/em>\u548c<em style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">JAK2<\/em>\u57fa\u56e0\uff08\u5e72\u6270\u7d20-\u03b3\u514d\u75ab\u4fe1\u53f7\u901a\u8def\u4e2d\u7684\u5173\u952e\u6210\u5206\uff09\u7684\u529f\u80fd\u7f3a\u9677\u7a81\u53d8\u4e0e\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u539f\u53d1\u6027\u548c\u83b7\u5f97\u6027\u8010\u836f\u76f8\u5173\u3002<\/strong>\u540c\u65f6\uff0c\u5728\u5bf9PD-1\u4ea7\u751f\u6297\u6027\u7684\u60a3\u8005\u4e2d\u4e5f\u89c2\u5bdf\u5230\u7f16\u7801\u03b22-\u5fae\u7403\u86cb\u767d\u7684\u57fa\u56e0\u53d1\u751f\u6709\u5bb3\u7a81\u53d8\uff0c\u8be5\u86cb\u767d\u5728\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53\uff08MHC\uff09\u5411\u514d\u75ab\u7cfb\u7edf\u5448\u9012\u6297\u539f\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u8868\u9762MHC\u7f3a\u5931\u53ef\u80fd\u4f7f\u8fd9\u4e9b\u764c\u7ec6\u80de\u201c\u8eb2\u8fc7\u201d\u83b7\u5f97\u6027\u514d\u75ab\u7cfb\u7edf\u3002\u8fd9\u79cd\u5173\u4e8e\u764c\u7ec6\u80de\u5982\u4f55\u901a\u8fc7\u7279\u5b9a\u7a81\u53d8\u9003\u907f\u514d\u75ab\u53cd\u5e94\u548c\u62b5\u6297\u514d\u75ab\u7597\u6cd5\u7684\u77e5\u8bc6\u63d0\u9ad8\u4e86\u533b\u751f\u5bf9\u8fd9\u4e9b\u5177\u6709\u6311\u6218\u6027\u7684\u75c5\u4f8b\u7684\u7406\u89e3\uff0c\u5e76\u63d0\u51fa\u4e86\u6709\u671b\u6cbb\u7597\u8fd9\u4e9b\u60a3\u8005\u7684\u7b56\u7565\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">14. 2015\uff1aStefani Spranger\u535a\u58eb\u548cThomas Gajewski\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532674343.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">T\u7ec6\u80de\u662f\u6211\u4eec\u514d\u75ab\u7cfb\u7edf\u4e2d\u6700\u5f3a\u5927\u7684\u6297\u764c\u7ec6\u80de\uff0c\u56e0\u6b64\u5927\u591a\u6570\u514d\u75ab\u7597\u6cd5\u76f4\u63a5\u6216\u95f4\u63a5\u5730\u4fc3\u4f7f\u6740\u4f24\u6027T\u7ec6\u80de\u653b\u51fb\u548c\u6d88\u706d\u80bf\u7624\u3002\u4f8b\u5982\u68c0\u67e5\u70b9\u6291\u5236\u5242\u901a\u8fc7\u6fc0\u6d3b\u80bf\u7624\u7ec4\u7ec7\u5185\u7684T\u7ec6\u80de\uff0c\u56e0\u6b64\u5728\u5df2\u88abT\u7ec6\u80de\u8bc6\u522b\u548c\u6d78\u6da6\u7684\u80bf\u7624\u60a3\u8005\u4e2d\u8d77\u4f5c\u7528\u6700\u4f73\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u5927\u591a\u6570\u60a3\u8005\u7684T\u7ec6\u80de\u672a\u80fd\u6e17\u900f\u80bf\u7624\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4\u764c\u75c7\u9003\u907f\u514d\u75ab\u53cd\u5e94\u5e76\u9650\u5236\u68c0\u67e5\u70b9\u514d\u75ab\u7597\u6cd5\u7684\u6709\u6548\u6027\u30022015\u5e74\uff0cStefani Spranger \u535a\u58eb\u4e0eThomas Gajewski\u535a\u58eb\u5408\u4f5c\uff0c\u5728\u829d\u52a0\u54e5\u5927\u5b66\u7814\u7a76\u53d1\u73b0\u764c\u75c7\u53ef\u4ee5\u901a\u8fc7\u7ec4\u7ec7T\u7ec6\u80de\u6d78\u5165\u80bf\u7624\u6765\u4fdd\u62a4\u81ea\u8eab\u3002\u5728\u786e\u5b9aWnt \/\u03b2-\u8fde\u73af\u86cb\u767d\u901a\u8def\u7684\u6fc0\u6d3b\u4e0e\u4eba\u9ed1\u8272\u7d20\u7624\u6837\u54c1\u4e2d\u7f3a\u4e4f\u514d\u75ab\u6d78\u6da6\u4e4b\u95f4\u7684\u5173\u8054\u540e\uff0c\u4ed6\u4eec\u4f7f\u7528\u9ed1\u8272\u7d20\u7624\u7684\u5c0f\u9f20\u6a21\u578b\u6765\u7814\u7a76Wnt \/\u03b2-\u8fde\u73af\u86cb\u767d\u901a\u8def\u6d3b\u6027\u5982\u4f55\u51cf\u5c11\u6811\u7a81\u7ec6\u80de\u6d3b\u6027\u5e76\u6291\u5236T\u7ec6\u80de\u5230\u8fbe\u80bf\u7624\u90e8\u4f4d\u3002\u5148\u524d\uff0c\u68c0\u67e5\u70b9\u514d\u75ab\u7597\u6cd5\u5728\u6d88\u706d\u8fd9\u4e9b\u7f3a\u4e4fT\u7ec6\u80de\u7684\u80bf\u7624\u65b9\u9762\u6548\u679c\u8f83\u5dee\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u4e8e\u8fd9\u9879\u53d1\u73b0\uff0c\u6211\u4eec\u73b0\u5728\u5df2\u7ecf\u5f00\u53d1\u51fa\u4e86\u9488\u5bf9\u8be5\u901a\u8def\u7684\u65b9\u6cd5\uff0c\u5e76\u53ef\u80fd\u63d0\u9ad8\u8fd9\u4e9b\u60a3\u8005\u7684\u514d\u75ab\u7597\u6cd5\u7684\u6709\u6548\u6027\u3002<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">15. 2004\uff1aKang Liu\u548c\u535a\u58ebRalph Steinman\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532674344.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6211\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u7684\u60ca\u4eba\u529b\u91cf\u6e90\u4e8e\u5b83\u7684\u9002\u5e94\u80fd\u529b\u2014\u2014\u4e0d\u65ad\u5b66\u4e60\u5a01\u80c1\uff0c\u7136\u540e\u9488\u5bf9\u5b83\u4eec\u505a\u51fa\u7cbe\u786e\u7684\u53cd\u5e94\u3002\u5c3d\u7ba1T\u7ec6\u80de\u76f4\u63a5\u53c2\u4e0e\u5e76\u6d88\u9664\u764c\u7ec6\u80de\uff0c\u4f46\u662f\u79f0\u4e3a\u6811\u7a81\u7ec6\u80de\uff08DC\uff09\u7684\u514d\u75ab\u7ec6\u80de\u5728\u5e2e\u52a9\u534f\u8c03\u8fd9\u4e9b\u603b\u4f53\u53cd\u5e94\u65b9\u9762\u53d1\u6325\u540c\u6837\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u4f7fT\u7ec6\u80de\u80fd\u591f\u6210\u529f\u5bfb\u627e\u5408\u9002\u7684\u76ee\u6807\u3002\u9664\u4e86\u628aT\u7ec6\u80de\u52df\u96c6\u5230\u80bf\u7624\u90e8\u4f4d\uff0c\u7136\u540e\u5728\u5176\u8868\u9762\u4e0a\u5448\u9012\u764c\u7ec6\u80de\u6807\u5fd7\u7269\uff08\u4e5f\u79f0\u4e3a\u5176\u6297\u539f\uff09\u4e4b\u5916\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\u8fd8\u53ef\u4ee5\u6559T\u7ec6\u80de\u8ba4\u8bc6\u764c\u75c7\u7ec6\u80de\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0cRalph Steinman\u535a\u58eb\u548cKang Liu\u535a\u58eb\u900f\u9732\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">CD40\u9014\u5f84\u5728\u5929\u7136\u548c\u83b7\u5f97\u6027\u514d\u75ab\u4e4b\u95f4\u63d0\u4f9b\u4e86\u81f3\u5173\u91cd\u8981\u7684\u8054\u7cfb\uff0c\u901a\u8fc7\u4ea7\u751f\u201c\u6740\u624b\u201dT\u7ec6\u80de\u4ee5\u53ca\u201c\u8f85\u52a9\u201dT\u7ec6\u80de\u4fc3\u8fdb\u83b7\u5f97\u6027\u514d\u75ab\u5e94\u7b54\u3002<\/strong>\u56e0\u6b64\uff0c\u65e8\u5728\u6fc0\u6d3bCD40\u9014\u5f84\u3001\u52a0\u5f3a\u60a3\u8005\u5bf9\u764c\u75c7\u7684\u514d\u75ab\u5e94\u7b54\u7684\u514d\u75ab\u7597\u6cd5\u6b63\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u4f30\uff0c\u5305\u62ec\u4e00\u9879CRI\u4e34\u5e8a\u52a0\u901f\u5668\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u76ee\u524d\u6b63\u5728\u80f0\u817a\u764c\u60a3\u8005\u4e2d\u6d4b\u8bd5\u57fa\u4e8eCD40\u7684\u514d\u75ab\u7ec4\u5408\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">16. 2017\uff1aMohammad Rashidian\u535a\u58eb\u548cHidde Ploegh\u535a\u58eb<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532674344.jpg\" alt=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\" title=\"1953-2018\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7fa4\u661f\u95ea\u8000\u65f6\uff08\u4e0a\u7bc7\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u68c0\u67e5\u70b9\u514d\u75ab\u7597\u6cd5\u5bf9\u4e8e\u5df2\u88ab\u201c\u6740\u624b\u201dT\u7ec6\u80de\u8bc6\u522b\u548c\u9776\u5411\u7684\u80bf\u7624\u6700\u6709\u6548\uff0c\u8fd9\u4e00\u8ba4\u8bc6\u5bf9\u4e8e\u533b\u751f\u6765\u8bf4\u662f\u975e\u5e38\u6709\u4ef7\u503c\uff0c\u56e0\u4e3a\u5b83\u53ef\u4ee5\u5e2e\u52a9\u4ed6\u4eec\u8bc6\u522b\u6700\u6709\u53ef\u80fd\u4ece\u6cbb\u7597\u4e2d\u53d7\u76ca\u7684\u60a3\u8005\u3002\u4f46\u662f\uff0c\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u83b7\u53d6\u8fd9\u4e9b\u4fe1\u606f\u9700\u8981\u8fdb\u884c\u4fb5\u5165\u6027\u80bf\u7624\u6d3b\u68c0\u3002\u5e78\u8fd0\u7684\u662f\uff0cHidde Ploegh\u548cMohamad Rashidian\u535a\u58eb\u7684\u7814\u7a76\u8868\u660e\uff0c\u514d\u75abPET\u6210\u50cf\u53ef\u7528\u4e8e\u89c2\u5bdf\u5c0f\u9f20\u80bf\u7624\u5185\u7684\u8fd9\u4e9b\u6740\u4f24T\u7ec6\u80de\u3002\u6b64\u5916\uff0c\u4ed6\u4eec\u8fd8\u53d1\u73b0\uff0c\u4e0d\u540c\u7684\u80bf\u7624\u514d\u75ab\u6d78\u6da6\u6a21\u5f0f\u4e0e\u4e0d\u540c\u7684\u7ed3\u679c\u76f8\u5173\uff1a<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">T\u7ec6\u80de\u5747\u5300\u6d78\u6da6\u80bf\u7624\u7684\u5c0f\u9f20\u5bf9\u68c0\u67e5\u70b9\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u7684\u53ef\u80fd\u6027\u8981\u9ad8\u4e8e\u53ea\u6709T\u7ec6\u80de\u6d78\u6da6\u80bf\u7624\u7684\u5c0f\u9f20\u3002<\/strong>\u8fd9\u4e00\u7b56\u7565\u76ee\u524d\u6b63\u5728\u8f6c\u5316\u4e3a\u4e34\u5e8a\u7b56\u7565\uff0c\u5e2e\u52a9\u533b\u751f\u786e\u5b9a\u53ef\u80fd\u5bf9\u514d\u75ab\u6cbb\u7597\u6709\u53cd\u5e94\u7684\u60a3\u8005\uff0c\u5e76\u4e14\u53ef\u4ee5\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u8ffd\u8e2a\u60a3\u8005\u514d\u75ab\u6d3b\u52a8\uff0c\u786e\u8ba4\u4ed6\u4eec\u662f\u5426\u5bf9\u836f\u7269\u6709\u53cd\u5e94\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\">[1] 30 Days of CRI Impact: Laying the Foundation for Cancer Immunotherapy<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(102, 102, 102);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;font-style: italic;letter-spacing: 0.544px;text-indent: 32px;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6587\u7ae0\u4fe1\u606f\u6e90\u4e8e\u516c<\/span><span style=\"max-width: 100%;color: rgb(102, 102, 102);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;font-style: italic;letter-spacing: 0.544px;text-indent: 32px;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f17<\/span><span style=\"max-width: 100%;color: rgb(102, 102, 102);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;font-style: italic;letter-spacing: 0.544px;text-indent: 32px;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53f7<\/span><span style=\"max-width: 100%;color: rgb(102, 102, 102);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;font-style: italic;letter-spacing: 0.544px;text-indent: 32px;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important;\">\u836f\u660e\u5eb7\u5fb7<\/span><span style=\"max-width: 100%;color: rgb(102, 102, 102);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;font-style: italic;letter-spacing: 0.544px;text-indent: 32px;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c<\/span><span style=\"max-width: 100%;color: rgb(102, 102, 102);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;font-style: italic;letter-spacing: 0.544px;text-indent: 32px;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important;\">\u767b\u8f7d<\/span><span style=\"max-width: 100%;color: rgb(102, 102, 102);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;font-style: italic;letter-spacing: 0.544px;text-indent: 32px;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8be5\u6587\u7ae0\u76ee\u7684\u4e3a\u66f4\u5e7f\u6cdb\u7684\u4f20\u9012\u884c\u4e1a\u4fe1\u606f\uff0c\u4e0d\u4ee3\u8868\u8d5e\u540c\u5176\u89c2\u70b9\u6216\u5bf9\u5176\u771f\u5b9e\u6027\u8d1f\u8d23\u3002\u6587\u7ae0\u7248\u6743\u5f52\u539f\u4f5c\u8005\u53ca\u539f\u51fa\u5904\u6240\u6709\uff0c\u6587\u7ae0\u5185\u5bb9\u4ec5\u4f9b\u53c2\u8003\u3002\u672c\u7f51\u62e5\u6709\u5bf9\u6b64\u58f0\u660e\u7684\u6700\u7ec8\u89e3\u91ca\u6743\uff0c\u82e5\u65e0\u610f\u4fb5\u72af\u7248\u6743\uff0c\u8bf7\u8054\u7cfb\u5c0f\u7f16\u5220\u9664\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p><br  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"margin-right: auto;margin-left: auto;max-width: 100%;width: 333.594px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;display: inline-block;width: 333.594px;vertical-align: top;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 133.438px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-top: 1px dotted rgb(223, 223, 223);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 50.0312px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-top: 5px;margin-bottom: 10px;max-width: 100%;line-height: 0.8;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;display: inline-block;border-top: 0.8em solid rgb(187, 227, 197);word-wrap: break-word !important;border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 133.438px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-top: 1px dotted rgb(223, 223, 223);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 14px;letter-spacing: 0px;line-height: 2;color: rgb(160, 160, 160);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 0em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 133.438px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-top: 18px;margin-bottom: 8px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-top: 1px dotted rgb(223, 223, 223);word-wrap: 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!important;\">\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u884c\u821fDrug                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u70b9\u51fb\u4e0a\u65b9\u7684&nbsp;\u884c\u821fDrug&nbsp;\u25b2&nbsp;\u6dfb\u52a0\u5173\u6ce8 \u258e\u836f\u660e\u5eb7\u5fb7\/\u7f16\u8bd1\uff08\u6765\u6e90\uff1aCRI\uff09 \u7f16\u8005\u6309 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