{"id":43823,"date":"2018-08-28T01:00:00","date_gmt":"2018-09-17T07:19:31","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/17\/%e5%a5%b3%e6%80%a7%e5%81%a5%e5%ba%b7%e7%94%a8%e8%8d%afelagolix%e6%9c%89%e6%9c%9b%e6%88%90%e4%b8%ba%e9%87%8d%e7%a3%85%e7%82%b8%e5%bc%b9-2\/"},"modified":"2018-09-17T15:19:32","modified_gmt":"2018-09-17T07:19:32","slug":"%e5%a5%b3%e6%80%a7%e5%81%a5%e5%ba%b7%e7%94%a8%e8%8d%afelagolix%e6%9c%89%e6%9c%9b%e6%88%90%e4%b8%ba%e9%87%8d%e7%a3%85%e7%82%b8%e5%bc%b9-2","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/43823\/","title":{"rendered":"\u5973\u6027\u5065\u5eb7\u7528\u836fElagolix\u6709\u671b\u6210\u4e3a\u201c\u91cd\u78c5\u70b8\u5f39\u201d"},"content":{"rendered":"
\n
\n
\n
\n

\u5b50\u5bab\u5185\u819c\u4e2d\u96cc\u6fc0\u7d20\u6c34\u5e73\u7684\u964d\u4f4e\u4f7felagolix\u80fd\u88ab\u7528\u4e8e\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u6240\u81f4\u7684\u75bc\u75db\uff0c\u5df2\u7ecf\u83b7\u51c6\u3002<\/span><\/span><\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

 \u5168\u65872462\u5b57\uff0c\u7528\u65f65\u5206\u949f<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4f5c\u8005\uff1a\u8bb8\u5173\u715c\u3001\u674e\u654f\u534e<\/span><\/p>\n

Elagolix\uff08\u827e\u62c9\u6208\u5229\uff09\u662f\u4e00\u79cd\u77ed\u6548\u4fc3\u6027\u817a\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\uff08GnRH\uff09\u62ee\u6297\u5242\uff0cElagolix\u9488\u5bf9\u4e0b\u4e18\u8111GnRH\u7684\u751f\u7269\u5b66\u9776\u70b9\uff0c\u901a\u8fc7\u963b\u65adGnRH\uff0c\u53ef\u4ee5\u5feb\u901f\u53ef\u9006\u3001\u5242\u91cf\u4f9d\u8d56\u6027\u5730\u6291\u5236\u6027\u817a\u7684\u5206\u6ccc\uff0c\u4ece\u800c\u6291\u5236\u6027\u6fc0\u7d20\uff0c\u5982\u96cc\u4e8c\u9187\uff0c\u9ec4\u4f53\u916e\u548c\u777e\u916e\u7684\u5faa\u73af\u6c34\u5e73\u3002\u5b50\u5bab\u5185\u819c\u4e2d\u96cc\u6fc0\u7d20\u6c34\u5e73\u7684\u964d\u4f4e\u4f7felagolix\u80fd\u88ab\u7528\u4e8e\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u6240\u81f4\u7684\u75bc\u75db\uff0c\u5df2\u7ecf\u83b7\u51c6\u3002\u5b83\u4e5f\u6b63\u5728\u88ab\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5973\u6027\u5b50\u5bab\u808c\u7624\uff0c\u8fd8\u66fe\u7ecf\u88ab\u7814\u7a76\u7528\u4e8e\u524d\u5217\u817a\u764c\u548c\u524d\u5217\u817a\u80a5\u5927\u7684\u836f\u7269\uff0c\u4e0d\u8fc7\u76f8\u5173\u5f00\u53d1\u5df2\u7ecf\u505c\u6b62\u3002\u5b83\u7531Neurocrine\u751f\u7269\u79d1\u5b66\u516c\u53f8\u5728\u591a\u5e74\u524d\u53d1\u73b0\uff0c\u901a\u8fc7\u4e0e\u827e\u4f2f\u7ef4\u516c\u53f8\u7d27\u5bc6\u5408\u4f5c\u53d6\u5f97\u4e86\u4e30\u7855\u6210\u679c\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5df2\u7ecf\u572840\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5171\u8ba1\u6709\u8d85\u8fc73700\u540d\u53d7\u8bd5\u8005\u63a5\u53d7\u6cbb\u7597\u3002\u5176\u7528\u4e8e\u7ba1\u7406\u5b50\u5bab\u808c\u7624\u7684elagolix\u7684III\u671f\u7814\u7a76\u6b63\u5728\u987a\u5229\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n

<\/span><\/p>\n

\n

\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u76f8\u5173\u7684\u75bc\u75db\u9002\u5e94\u75c7\u5df2\u83b7\u51c6<\/strong><\/p>\n<\/section>\n

7\u670824\u65e5\uff0c\u827e\u4f2f\u7ef4\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u6279\u51c6Elagolix\uff0c\u5546\u54c1\u540dOrilissa\uff0c\u4ece\u800c\u5b83\u6210\u4e3a\u9996\u4e2a\u4e5f\u662f\u552f\u4e00\u4e00\u4e2a\u53e3\u670d\u975e\u80bd\u7c7b\u5c0f\u5206\u5b50\u4fc3\u6027\u817a\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\uff08GnRH\uff09\u53d7\u4f53\u62ee\u6297\u5242\u3002\u8be5\u836f\u901a\u8fc7\u4e0e\u8111\u5782\u4f53\u4e2d\u7684GnRH\u53d7\u4f53\u7ade\u4e89\u6027\u7ed3\u5408\u6765\u6291\u5236\u5185\u6e90\u6027GnRH\u4fe1\u53f7\u4f20\u5bfc\uff0c\u4f7f\u6027\u6fc0\u7d20\u3001\u96cc\u4e8c\u9187\u548c\u9ec4\u4f53\u916e\u7684\u8840\u836f\u6d53\u5ea6\u964d\u4f4e\uff0c\u662f\u4e13\u95e8\u4e3a\u60a3\u6709\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u75bc\u75db\u7684\u5973\u6027\u5f00\u53d1\u3002FDA\u7ed9\u4e88Orilissa\u4f18\u5148\u8bc4\u5ba1\u5f85\u9047\uff0c\u5b83\u662fFDA\u6700\u8fd110\u4f59\u5e74\u6765\u6279\u51c6\u7684\u7b2c\u4e00\u4e2a\u7528\u4e8e\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u75bc\u75db\u7684\u53e3\u670d\u6cbb\u7597\u836f\uff0c\u8ba1\u5212\u4e8e2018\u5e748\u6708\u521d\u5728\u7f8e\u56fd\u96f6\u552e\u836f\u5e97\u9500\u552e\u3002<\/span><\/p>\n

\u7531\u4e8e\u5176\u975e\u80bd\u5c0f\u5206\u5b50\u6027\u8d28\u53ca\u5176\u53e3\u670d\u6d3b\u6027\uff0cElagolix\u88ab\u79f0\u4e3a\u201c\u7b2c\u4e8c\u4ee3\u201dGnRH\u8c03\u8282\u5242\u3002\u548c\u8f83\u8001\u7684GnRH\u62ee\u6297\u5242\uff08\u591a\u80bd\u7c7b\u548c\u7b2c\u4e00\u4ee3GnRH\u8c03\u8282\u5242\uff09\u4e0d\u540c\uff0c\u5b83\u4e0d\u662fGnRH\u7c7b\u4f3c\u7269\uff0c\u5728\u7ed3\u6784\u4e0a\u4e0eGnRH\u6ca1\u6709\u76f8\u5173\u6027\u3002Orilissa\u662f\u7b2c\u4e00\u4e2a\u4e5f\u662f\u76ee\u524d\u552f\u4e00\u7b2c\u4e8c\u4ee3\u548c\u53e3\u670d\u6709\u6548\u7684GnRH\u8c03\u8282\u5242\uff0c\u6bcf\u6708\u6cbb\u7597\u82b1\u8d39\u7ea6850\u7f8e\u5143\u3002<\/span><\/p>\n

\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u662f\u6700\u5e38\u89c1\u7684\u5987\u79d1\u75be\u75c5\u4e4b\u4e00\u3002\u636e\u4f30\u8ba1\uff0c\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u591a\u8fbe1.76\u4ebf\u5973\u6027\u906d\u53d7\u6b64\u75c7\u56f0\u6270\u3002\u5728\u7f8e\u56fd\u6bcf10\u540d\u80b2\u9f84\u5987\u5973\u4e2d\u5c31\u6709\u4e00\u4eba\u60a3\u6709\u8fd9\u79cd\u75be\u75c5\u3002\u56fd\u5185\u6570\u636e\u663e\u793a\uff0c\u5728\u5973\u6027\u4eba\u7fa4\u4e2d\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u7684\u53d1\u75c5\u7387\u7ea6\u4e3a10\uff05\uff0c\u75db\u7ecf\u7684\u5987\u5973\u4e2d\u670940\uff05-60\uff05\u662f\u6b64\u75c5\u6240\u81f4\u3002\u800c\u5728\u4e0d\u5b55\u7684\u5987\u5973\u4e2d\uff0c\u7531\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u5f15\u8d77\u7684\u4e3a20\uff05-30\uff05\u3002\u60a3\u8005\u4e3a\u660e\u786e\u8bca\u65ad\u5f80\u5f80\u9700\u8981\u591a\u65b9\u6c42\u533b\uff0c\u65f6\u95f4\u751a\u81f3\u957f\u8fbe6~10\u5e74\u3002<\/span><\/p>\n

\u4e4b\u524d\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u6cbb\u7597\u901a\u5e38\u4ee5\u53e3\u670d\u907f\u5b55\u836f\u3001\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\uff08NSAIDs\uff09\u3001\u963f\u7247\u7c7b\u836f\u7269\u548c\u6fc0\u7d20\u7597\u6cd5\u7b49\u7597\uff0c\u8fd9\u4e9b\u836f\u7269\u5bf9\u67d0\u4e9b\u5973\u6027\u6709\u6548\uff0c\u4f46\u5f88\u5c11\u6709\u7279\u522b\u9002\u7528\u4e8e\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u7684\u6cbb\u7597\u3002\u66f4\u591a\u75c5\u4f8b\u8fdb\u884c\u624b\u672f\u5e72\u9884\uff08\u4f8b\u5982\uff0c\u5256\u8179\u624b\u672f\u3001\u8179\u8154\u955c\u68c0\u67e5\u6216\u5b50\u5bab\u5207\u9664\u672f\uff09\uff0c\u5e76\u4e14\u65e0\u6cd5\u6cbb\u6108\u6240\u6709\u60a3\u8005\u3002\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u901a\u5e38\u4ee5\u6162\u6027\u76c6\u8154\u75bc\u75db\u4e3a\u7279\u5f81\uff0c\u53ef\u5f71\u54cd\u5973\u6027\u7684\u65e5\u5e38\u6d3b\u52a8\u3002\u60a3\u6709\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u7684\u5987\u5973\u53ef\u80fd\u9700\u8981\u63a5\u53d7\u591a\u79cd\u533b\u5b66\u6cbb\u7597\u4ee5\u5bfb\u6c42\u7f13\u89e3\u75bc\u75db\u3002<\/span><\/p>\n

Elagolix\u7684\u8fd9\u9879\u6279\u51c6\u4e3a\u533b\u5e08\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u53ef\u6839\u636e\u5973\u6027\u7279\u5b9a\u7c7b\u578b\u548c\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u75bc\u75db\u7684\u4e25\u91cd\u7a0b\u5ea6\u8fdb\u884c\u6cbb\u7597\u3002<\/span><\/p>\n

\u5728\u6240\u5f00\u5c55\u7684\u4e00\u9879\u6700\u5927\u89c4\u6a21\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7III\u671f\u7814\u7a76\u8ba1\u5212\u4e2d\uff0c\u4e24\u9879\u91cd\u590d\u7814\u7a76\u6570\u636e\u5747\u652f\u6301\u8be5\u4e00\u6279\u51c6\u51b3\u7b56\uff0c\u7814\u7a76\u8bc4\u4f30\u4e86\u8fd11700\u540d\u60a3\u6709\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u75bc\u75db\u7684\u5973\u6027\u3002\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u663e\u793aOrilissa\u663e\u8457\u51cf\u5c11\u4e86\u4e09\u79cd\u6700\u5e38\u89c1\u7c7b\u578b\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u75bc\u75db\uff1a\u6708\u7ecf\u9aa8\u76c6\u75bc\u75db\u3001\u975e\u7ecf\u671f\u9aa8\u76c6\u75bc\u75db\u548c\u6027\u4ea4\u75bc\u75db\u3002\u5728\u7b2c3\u4e2a\u6708\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u670d\u7528Orilissa 150 mg\u6bcf\u65e5\u4e00\u6b21\u548c200 mg\u6bcf\u65e5\u4e24\u6b21\u6cbb\u7597\u7684\u5973\u6027\u60a3\u8005\u7684\u6708\u7ecf\u75bc\u75db\u548c\u975e\u7ecf\u671f\u9aa8\u76c6\u75bc\u75db\u5e94\u7b54\uff08\u663e\u793a\u6548\u679c\uff09\u8005\u6bd4\u4f8b\u8f83\u9ad8\u3002\u7ecf\u5386\u6708\u7ecf\u75bc\u75db\u548c\u975e\u7ecf\u671f\u9aa8\u76c6\u75bc\u75db\u51cf\u5c11\u800c\u6ca1\u6709\u589e\u52a0\u9547\u75db\u836f\uff08NSAIDs\u3001\u963f\u7247\u7c7b\uff09\u4f7f\u7528\u8005\u88ab\u5b9a\u4e49\u4e3a\u5e94\u7b54\u8005\u3002<\/span><\/p>\n

\u5728\u7b2c6\u4e2a\u6708\uff0cOrilissa\u6cbb\u7597\u7ec4\u5728\u6708\u7ecf\u75bc\u75db\u548c\u975e\u6708\u7ecf\u9aa8\u76c6\u75bc\u75db\u65b9\u9762\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u663e\u793a\u81ea\u57fa\u7ebf\u66f4\u5927\u7684\u4e2d\u4f4d\u503c\u964d\u4f4e\u3002III\u671f\u7814\u7a76\u4e2d\u4e5f\u4f7f\u7528\u6570\u5b57\u8bc4\u5b9a\u91cf\u8868\uff08NRS\uff09\u5bf9\u5176\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u75bc\u75db\u8fdb\u884c\u6bcf\u65e5\u81ea\u6211\u8bc4\u4f30\uff0c\u6bcf\u65e5\u670d\u7528Orilissa 150 mg\u4e00\u6b21\uff0c\u6bcf\u65e5\u670d\u7528200 mg\u4e24\u6b21\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\u5728\u7b2c\u4e09\u4e2a\u6708NRS\u8bc4\u5206\u6bd4\u57fa\u7ebf\u663e\u8457\uff08p <0.001\uff09\u964d\u4f4e\u3002\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u8fd8\u8868\u660e\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u670d\u7528Orilissa 200 mg\u6bcf\u65e5\u4e24\u6b21\u7684\u5973\u6027\u7b2c\u4e09\u4e2a\u6708\u7684\u6027\u4ea4\u75bc\u75db\u4ece\u57fa\u7ebf\u663e\u8457\u4e0b\u964d\u3002<\/span><\/p>\n

\u63a8\u8350\u7684Orilissa\u6301\u7eed\u4f7f\u7528\u65f6\u95f4\u4e3a150 mg\u6bcf\u65e5\u4e00\u6b21\u6700\u591a24\u4e2a\u6708\uff0c200 mg\u6bcf\u65e5\u4e24\u6b21\u6700\u591a6\u4e2a\u6708\uff0c\u56e0\u4e3a\u5b83\u4f1a\u5bfc\u81f4\u9aa8\u77ff\u7269\u8d28\u5bc6\u5ea6\uff08BMD\uff09\u5242\u91cf\u4f9d\u8d56\u6027\u964d\u4f4e\u3002BMD\u635f\u5931\u968f\u7740\u4f7f\u7528\u6301\u7eed\u65f6\u95f4\u7684\u589e\u52a0\u800c\u589e\u52a0\uff0c\u5e76\u4e14\u5728\u505c\u6b62\u6cbb\u7597\u540e\u53ef\u80fd\u4e0d\u662f\u5b8c\u5168\u53ef\u9006\u7684\u3002\u5bf9\u4e8e\u4e2d\u5ea6\u809d\u529f\u80fd\u4e0d\u5168\u7684\u5973\u6027\uff0c\u63a8\u8350\u5242\u91cf\u4e3a150 mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u6700\u957f\u53ef\u8fbe6\u4e2a\u6708\u3002\u5efa\u8bae\u6bcf\u5929\u5728\u540c\u4e00\u65f6\u95f4\u53e3\u670d\uff0c\u968f\u6216\u4e0d\u968f\u98df\u7269\u3002<\/span><\/p>\n

<\/span><\/p>\n

\n

\u6cbb\u7597\u5b50\u5bab\u808c\u7624\u7814\u7a76\u83b7\u5f97\u79ef\u6781\u7ed3\u679c<\/strong><\/p>\n<\/section>\n

8\u670822\u65e5\uff0c\u827e\u4f2f\u7ef4\u516c\u53f8\u53d1\u5e03\u4e86Elagolix\u5728\u5b50\u5bab\u808c\u7624\u60a3\u8005\u4e2d\u7684III\u671f\u5ef6\u4f38\u7814\u7a76\u7684\u6700\u7ec8\u7ed3\u679c\u3002\u7814\u7a76\u8868\u660e\uff0c\u7ecf\u8fc7\u4e00\u5e74\u6cbb\u7597\uff0cElagolix\u52a0\u4f4e\u5242\u91cf\u6fc0\u7d20\u6cbb\u7597\u51cf\u5c11\u4e86\u6708\u7ecf\u51fa\u8840\uff0c\u8fd188\uff05\u5973\u6027\u8868\u73b0\u51fa\u4e34\u5e8a\u5e94\u7b54\u3002\u827e\u4f2f\u7ef4\u8ba1\u5212\u4e8e2019\u5e74\u63d0\u4ea4\u7528\u4e8e\u5b50\u5bab\u808c\u7624\u7684\u7533\u8bf7\u3002<\/span><\/p>\n

\u5927\u591a\u6570\u5973\u6027\u5728\u751f\u547d\u7684\u67d0\u4e2a\u9636\u6bb5\u4f1a\u51fa\u73b0\u5b50\u5bab\u808c\u7624\uff0c\u5176\u4e2d1\/4\u4f1a\u51fa\u73b0\u4e25\u91cd\u7684\u75bc\u75db\u75c7\u72b6\uff0c\u4ee5\u53ca\u6708\u7ecf\u5916\u9634\u9053\u51fa\u8840\u3002\u8fd9\u4e9b\u56e0\u7d20\u52a0\u5728\u4e00\u8d77\u53ef\u80fd\u5bfc\u81f4\u8d2b\u8840\u3002\u56fd\u5185\u6700\u65b0\u7edf\u8ba1\u8d44\u6599\u8868\u660e\uff0c\u5b50\u5bab\u808c\u7624\u572830\u5c81~50\u5c81\u7684\u5973\u6027\u53d1\u75c5\u7387\u7ea630%\uff0c\u5728\u5b50\u5bab\u5185\u6f5c\u5b58\u6709\u5927\u5c0f\u4e0d\u540c\u3001\u6570\u76ee\u4e0d\u7b49\u7684\u808c\u7624\u3002<\/span><\/p>\n

\u73b0\u6709\u7684\u5b50\u5bab\u808c\u7624\u6cbb\u7597\u65b9\u6cd5\u5305\u62ec\u624b\u672f\u3001\u6d88\u878d\u3001\u8d85\u58f0\u6ce2\u3001\u53e3\u670d\u907f\u5b55\u836f\u3001\u5b55\u6fc0\u7d20\u3001\u62e9\u6027\u5b55\u6fc0\u7d20\u53d7\u4f53\u8c03\u8282\u5242\u6216GnRH\u6fc0\u52a8\u5242\u2014\u2014\u4f46\u8fd9\u4e9b\u624b\u6bb5\u901a\u5e38\u4e0d\u80fd\u8fbe\u5230\u6ee1\u610f\u6548\u679c\u3002\u56e0\u6b64\uff0c\u5b50\u5bab\u808c\u7624\u7684\u5973\u6027\u6025\u9700\u6709\u65b0\u7684\u533b\u7597\u9009\u62e9\u3002<\/span><\/p>\n

\u827e\u4f2f\u7ef4\u7684\u5ef6\u4f38\u7814\u7a76\u63d0\u4f9b\u4e86\u53e6\u4e00\u5c42\u9762\u6570\u636e\uff0c\u4ee5\u652f\u63012019\u5e74\u63d0\u4ea4\u7684Elagolix\u7528\u4e8e\u8fd9\u4e00\u9002\u5e94\u75c7\u7684\u7533\u8bf7\uff0c\u5e76\u6709\u52a9\u4e8e\u5c06\u8be5\u836f\u5728\u5176\u5b83\u53ef\u7528\u7684\u624b\u672f\u548c\u533b\u7597\u5e72\u9884\u63aa\u65bd\u4e2d\u72ec\u6811\u4e00\u5e1c\u3002<\/span><\/p>\n

\u5728\u8fd9\u9879\u4e3a\u671f12\u4e2a\u6708\u7684\u5ef6\u4f38\u7814\u7a76\u4e4b\u524d\uff0c\u827e\u4f2f\u7ef4\u5df2\u7ecf\u5b8c\u6210\u4e86\u4e24\u9879\u5173\u952e\u6027\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d68.5\uff05\u548c76.2\uff05\u5973\u6027\u5206\u522b\u57286\u4e2a\u6708\u5185\u8fbe\u5230\u4e86\u4e34\u5e8a\u5e94\u7b54\u3002<\/span><\/p>\n

<\/span><\/p>\n

\n

\u5e02\u573a\u7684\u6bb7\u5207\u671f\u5f85<\/strong><\/p>\n<\/section>\n

\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u548c\u5b50\u5bab\u808c\u7624\u90fd\u662f\u5927\u591a\u6570\u5973\u6027\u7684\u7ec8\u8eab\u75be\u60a3\uff0c\u5bf9\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u6709\u5f88\u5927\u5f71\u54cd\u3002\u5e02\u573a\u7684\u6bb7\u5207\u671f\u5f85\u6b64\u7c7b\u836f\u7269\u3002Elagolix\u5e02\u573a\u524d\u666f\u5c24\u88ab\u770b\u597d\u3002\u8fd1\u5e74\u5168\u7403\u533b\u836f\u5065\u5eb7\u9886\u57df\u6743\u5a01\u6027\u884c\u4e1a\u54a8\u8be2\u53ca\u5e02\u573a\u8c03\u7814\u673a\u6784\u53d1\u5e03\u7684\u91cd\u78c5\u836f\u54c1\u9884\u6d4b\u4e2d\uff0cElagolix\u5747\u4e0d\u7ea6\u800c\u540c\u8d6b\u7136\u5728\u76ee\uff0c\u9884\u8ba1\u7684\u5e74\u9500\u552e\u989d\u8d85\u8fc710\u4ebf\u7f8e\u5143[12.1\u4ebf\u7f8e\u5143\u300114.88\uff082022\u5e74\uff09]<\/span><\/p>\n

\u65e5\u524d\uff0c\u6295\u8d44\u94f6\u884cLeerink\u7684Geoffrey Porges\u9884\u6d4b\uff0c2020\u5e74\u5b9e\u73b0Elagolix\u7528\u4e8e\u5b50\u5bab\u808c\u7624\uff0c\u5728\u8fd9\u4e00\u9002\u5e94\u75c7\u51c6\u4e4b\u540e\uff0c2023\u5e74\u5b83\u7684\u603b\u9500\u552e\u989d\u53ef\u8fbe\u523017\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

\u53e6\u5916\uff0c\u827e\u4f2f\u7ef4\u5c06\u4e0d\u5fc5\u62c5\u5fc3\u6765\u81ea\u827e\u7acb\u5efa\u7684\u5b55\u6fc0\u7d20\u53d7\u4f53\u8c03\u8282\u5242Esmya\uff08Ulipristal Acetate\uff0c\u918b\u9178\u4e4c\u5229\u53f8\u4ed6\uff09\u7684\u7ade\u4e89\uff0c\u8be5\u516c\u53f8\u4e8e\u4eca\u5e748\u670821\u65e5\u6536\u5230FDA\u56de\u590d\u51fd\uff0c\u51fa\u4e8e\u5bf9\u8be5\u836f\u5b89\u5168\u6027\u7684\u62c5\u5fe7\u5b83\u672a\u80fd\u83b7\u5f97\u6279\u51c6\u3002\u5728\u6b27\u6d32\uff0c\u4e0a\u5e02\u540e\u62a5\u544a\u67094\u4f8b\u4e25\u91cd\u809d\u635f\u4f24\uff0c\u5176\u4e2d3\u540d\u60a3\u8005\u6700\u7ec8\u63a5\u53d7\u809d\u79fb\u690d\u3002<\/span><\/p>\n

\u53e6\u5916\u8fd8\u6709\u51e0\u4e2a\u836f\u7269\u3002\u5982\u7531Kissei\u5236\u836f\u516c\u53f8\u548cObsEva\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5b50\u5bab\u808c\u7624\u3001\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u548c\u5b50\u5bab\u817a\u808c\u75c5\u7684Linzagolix\uff08\u4ee3\u53f7KLH-2109\uff0cOBE-2109\uff09\u4e5f\u662f\u4e00\u79cd\u5c0f\u5206\u5b50\u975e\u80bd\uff0c\u53e3\u670d\u6d3b\u6027GnRH\u62ee\u6297\u5242\uff0c\u6b63\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u30026\u6708\u4e0b\u65ec\uff0cObsEva SA\u53d1\u5e03Linzagolix\u6cbb\u7597EMs\u76f8\u5173\u75bc\u75dbIIb\u671f\u4e34\u5e8a\u768412\u5468\u79ef\u6781\u6570\u636e\u3002\u4e0d\u8fc7\uff0clinzagolix\u7684\u5e02\u573a\u6f5c\u529b\u8fdc\u4e0d\u5982Elagolix\u3002<\/span><\/p>\n

\u8be5\u6cbb\u7597\u9886\u57df\u5df2\u7ecf\u83b7\u51c6\u7684\u62dc\u5c14\u516c\u53f8\u7684Visanne\uff08dienogest\uff0c\u5730\u8bfa\u5b55\u7d20\uff09\uff08\u5b55\u6fc0\u7d20\u62ee\u6297\u5242\uff09\u3001\u827e\u4f2f\u7ef4\u516c\u53f8\u7684Leuplin[\u9ec4\u4f53\u751f\u6210\u7d20\u91ca\u653e\u6fc0\u7d20\uff08LHRH\uff09\u7c7b\u4f3c\u7269]\u7684\u4ef7\u503c\u90fd\u65e0\u6cd5\u4e0eElagolix\u6bd4\u62df\u7684\u3002<\/span><\/p>\n

\"\u5973\u6027\u5065\u5eb7\u7528\u836fElagolix\u6709\u671b\u6210\u4e3a\u201c\u91cd\u78c5\u70b8\u5f39\u201d\"<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u5b50\u5bab\u5185\u819c\u4e2d\u96cc\u6fc0\u7d20\u6c34\u5e73\u7684\u964d\u4f4e\u4f7felagolix\u80fd\u88ab\u7528\u4e8e\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u6240\u81f4\u7684\u75bc\u75db\uff0c\u5df2\u7ecf\u83b7\u51c6\u3002  \u5168\u6587 […]<\/p>\n","protected":false},"author":1,"featured_media":43824,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/43823"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=43823"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/43823\/revisions"}],"predecessor-version":[{"id":43826,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/43823\/revisions\/43826"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/43824"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=43823"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=43823"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=43823"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}