{"id":4538,"date":"2018-07-05T01:00:00","date_gmt":"2018-07-27T06:53:24","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e5%9f%ba%e5%9b%a0%e6%af%92%e6%80%a7%e6%9d%82%e8%b4%a8%e4%bb%8b%e7%bb%8d%e5%8f%8a%e6%a3%80%e6%b5%8b%e6%96%b9%e6%b3%95\/"},"modified":"2018-07-27T14:53:26","modified_gmt":"2018-07-27T06:53:26","slug":"%e5%9f%ba%e5%9b%a0%e6%af%92%e6%80%a7%e6%9d%82%e8%b4%a8%e4%bb%8b%e7%bb%8d%e5%8f%8a%e6%a3%80%e6%b5%8b%e6%96%b9%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/4538\/","title":{"rendered":"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;max-width: 100%;\">\u70b9\u51fb\u4e0a\u65b9\u7684&nbsp;\u884c\u821fDrug&nbsp;<span style=\"max-width: 100%;color: rgb(127, 127, 127);box-sizing: border-box !important;word-wrap: break-word !important;\">\u25b2&nbsp;\u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"margin-top: 8px;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;widows: 1;height: 32px;color: rgb(0, 187, 236);line-height: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-bottom: 1px solid rgb(227, 227, 227);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;max-width: 100%;line-height: 28px;border-bottom: 2px solid rgb(51, 102, 153);float: left;display: block;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);background-color: rgb(51, 102, 153);box-sizing: border-box !important;word-wrap: break-word !important;\">1<\/span><\/span><span class=\"\" style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;max-width: 100%;color: rgb(38, 38, 38);line-height: 28px;border-bottom: 2px solid rgb(51, 102, 153);float: left;display: block;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong class=\"\" style=\"max-width: 100%;color: rgb(51, 102, 153);line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4ec0\u4e48\u662f\u57fa\u56e0\u6bd2\u6027\u6742\u8d28<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: justify;\">\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\uff08\u6216\u9057\u4f20\u6bd2\u6027\u6742\u8d28\uff0cGenotoxic Impurity \uff0cGTI\uff09\u662f\u6307\u5316\u5408\u7269\u672c\u8eab\u76f4\u63a5\u6216\u95f4\u63a5\u635f\u4f24\u7ec6\u80deDNA\uff0c\u4ea7\u751f\u57fa\u56e0\u7a81\u53d8\u6216\u4f53\u5185\u8bf1\u53d8\uff0c\u5177\u6709\u81f4\u764c\u53ef\u80fd\u6216\u8005\u503e\u5411\u3002\u6f5c\u5728\u57fa\u56e0\u6bd2\u6027\u7684\u6742\u8d28\uff08Potential Genotoxic Impurity \uff0cPGI\uff09\u4ece\u7ed3\u6784\u4e0a\u770b\u7c7b\u4f3c\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\uff0c\u6709\u8b66\u793a\u6027\uff0c\u4f46\u672a\u7ecf\u5b9e\u9a8c\u8bc1\u660e\u7684\u9ec4\u66f2\u9709\u7d20\u7c7b\u3001\u4e9a\u785d\u80fa\u5316\u5408\u7269\u3001\u7532\u57fa\u78fa\u9178\u916f\u7b49\u5316\u5408\u7269\u5747\u4e3a\u5e38\u89c1\u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\uff0c\u8bb8\u591a\u5316\u7597\u836f\u7269\u4e5f\u5177\u6709\u4e00\u5b9a\u7684\u57fa\u56e0\u6bd2\u6027\uff0c\u5b83\u4eec\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u7531\u5316\u7597\u836f\u7269\u5bf9\u6b63\u5e38\u7ec6\u80de\u7684\u57fa\u56e0\u6bd2\u6027\u6240\u81f4\uff0c\u5982\u987a\u94c2\u3001\u5361\u94c2\u3001\u6c1f\u5c3f\u5627\u5576\u7b49\u3002<\/p>\n<p style=\"margin-top: 8px;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;widows: 1;height: 32px;color: rgb(0, 187, 236);line-height: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-bottom: 1px solid rgb(227, 227, 227);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;max-width: 100%;line-height: 28px;border-bottom: 2px solid rgb(51, 102, 153);float: left;display: block;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);background-color: rgb(51, 102, 153);box-sizing: border-box !important;word-wrap: break-word !important;\">2<\/span><\/span><span class=\"\" style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;max-width: 100%;color: rgb(38, 38, 38);line-height: 28px;border-bottom: 2px solid rgb(51, 102, 153);float: left;display: block;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong class=\"\" style=\"max-width: 100%;color: rgb(51, 102, 153);line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e3a\u4f55\u7740\u91cd\u7814\u7a76\u57fa\u56e0\u6bd2\u6027\u6742\u8d28<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u57fa\u56e0\u6bd2\u6027\u7269\u8d28\u7279\u70b9\u662f\u5728\u5f88\u4f4e\u6d53\u5ea6\u65f6\u5373\u53ef\u9020\u6210\u4eba\u4f53\u9057\u4f20\u7269\u8d28\u7684\u635f\u4f24\uff0c\u8fdb\u800c\u5bfc\u81f4\u57fa\u56e0\u7a81\u53d8\u5e76\u53ef\u80fd\u4fc3\u4f7f\u80bf\u7624\u53d1\u751f\u3002\u56e0\u5176\u6bd2\u6027\u8f83\u5f3a\uff0c\u5bf9\u7528\u836f\u7684\u5b89\u5168\u6027\u4ea7\u751f\u4e86\u5f3a\u70c8\u7684\u5a01\u80c1\uff0c\u8fd1\u5e74\u6765\u4e5f\u8d8a\u6765\u8d8a\u591a\u7684\u51fa\u73b0\u56e0\u4e3a\u5728\u5df2\u4e0a\u5e02\u836f\u54c1\u4e2d\u53d1\u73b0\u75d5\u91cf\u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u6b8b\u7559\u800c\u53d1\u751f\u5927\u8303\u56f4\u7684\u533b\u7597\u4e8b\u6545\uff0c\u88abFDA\u5f3a\u884c\u53ec\u56de\u7684\u6848\u4f8b\uff0c\u7ed9\u836f\u5382\u9020\u6210\u4e86\u5de8\u5927\u7684\u7ecf\u6d4e\u635f\u5931\u3002\u4f8b\u5982\u67d0\u77e5\u540d\u56fd\u9645\u5236\u836f\u5de8\u5934\u5728\u6b27\u6d32\u5e02\u573a\u63a8\u51fa\u7684HIV\u86cb\u767d\u9176\u6291\u5236\u5242\u7ef4\u62c9\u8d5b\u7279\u952d\uff08Viracept\uff0c mesylate)\uff0c2007 \u5e747\u6708\uff0cEMA\u6682\u505c\u4e86\u5b83\u5728\u6b27\u6d32\u7684\u6240\u6709\u5e02\u573a\u6d3b\u52a8\uff0c\u56e0\u4e3a\u5728\u5176\u4ea7\u54c1\u4e2d\u53d1\u73b0\u7532\u57fa\u78fa\u9178\u4e59\u916f\u8d85\u6807\uff0c\u7532\u57fa\u78fa\u9178\u4e59\u916f\u662f\u4e00\u79cd\u7ecf\u5178\u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\uff0c\u8be5\u4f01\u4e1a\u4e3a\u6b64\u4ed8\u51fa\u4e86\u5de8\u5927\u7684\u4ee3\u4ef7\uff0c\u5148\u5185\u90e8\u8c03\u67e5\u6b8b\u7559\u8d85\u6807\u7684\u539f\u56e0\uff0c\u56e0\u5728\u4eea\u5668\u8bbe\u5907\u6e05\u6d17\u65f6\u4e59\u9187\u672a\u88ab\u5b8c\u5168\u6e05\u9664\u800c\u6b8b\u7559\u4e0b\u6765\uff0c\u4e0e\u7532\u57fa\u78fa\u9178\u53cd\u5e94\u5f62\u6210\u7532\u57fa\u78fa\u9178\u4e59\u916f\u3002\u5728\u88ab\u8981\u6c42\u89e3\u51b3\u6c61\u67d3\u95ee\u9898\u540e\u8fd8\u88ab\u8981\u6c42\u505a\u6bd2\u6027\u7814\u7a76\uff0c\u4ee5\u66f4\u597d\u7684\u8bc4\u4f30\u5bf9\u60a3\u8005\u7684\u98ce\u9669\u3002\u540c\u65f6\u6709\u591a\u8fbe25000 \u540d\u60a3\u8005\u66b4\u9732\u4e8e\u8fd9\u4e2a\u5df2\u77e5\u7684\u9057\u4f20\u6bd2\u6027\u3002\u76f4\u5230\u89e3\u51b3\u4e86\u8fd9\u6240\u6709\u95ee\u9898\u540e EMA\u624d\u6062\u590d\u4e86\u5b83\u5728\u6b27\u6d32\u7684\u5e02\u573a\u6388\u6743\u3002<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u8fd1\u5e74\u6765\u5404\u56fd\u7684\u6cd5\u89c4\u673a\u6784\u5982ICH\u3001FDA\u3001EMA\u7b49\u90fd\u5bf9\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u6709\u4e86\u66f4\u660e\u786e\u7684\u8981\u6c42\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u836f\u4f01\u5728\u65b0\u836f\u7814\u53d1\u8fc7\u7a0b\u4e2d\u5c31\u7740\u91cd\u5173\u6ce8\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u63a7\u5236\u548c\u68c0\u6d4b\u3002<\/p>\n<p style=\"margin-top: 8px;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;widows: 1;height: 32px;color: rgb(0, 187, 236);line-height: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-bottom: 1px solid rgb(227, 227, 227);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;max-width: 100%;line-height: 28px;border-bottom: 2px solid rgb(51, 102, 153);float: left;display: block;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);background-color: rgb(51, 102, 153);box-sizing: border-box !important;word-wrap: break-word !important;\">3<\/span><\/span><span class=\"\" style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;max-width: 100%;color: rgb(38, 38, 38);line-height: 28px;border-bottom: 2px solid rgb(51, 102, 153);float: left;display: block;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong class=\"\" style=\"max-width: 100%;color: rgb(51, 102, 153);line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u54ea\u4e9b\u5316\u5408\u7269\u662f\u57fa\u56e0\u6bd2\u6027\u6742\u8d28<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u6742\u8d28\u7684\u7ed3\u6784\u591a\u79cd\u591a\u6837\uff0c\u5bf9\u4e8e\u7edd\u5927\u591a\u6570\u7684\u6742\u8d28\u800c\u8a00\uff0c\u5f80\u5f80\u6ca1\u6709\u5145\u5206\u7684\u6bd2\u6027\u6216\u81f4\u764c\u7814\u7a76\u6570\u636e\uff0c\u56e0\u800c\u96be\u4ee5\u5bf9\u5176\u8fdb\u884c\u5f52\u7c7b\u3002\u5728\u7f3a\u4e4f\u5b89\u5168\u6027\u6570\u636e\u652f\u6301\u7684\u60c5\u51b5\u4e0b\uff0c\u8fd9\u4e9b\u6cd5\u89c4\u548c\u6307\u5bfc\u539f\u5219\u91c7\u7528\u201c\u8b66\u793a\u7ed3\u6784\u201d\u4f5c\u4e3a\u533a\u5206\u666e\u901a\u6742\u8d28\u548c\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u6807\u5fd7\u3002\u5bf9\u4e8e\u542b\u6709\u8b66\u793a\u7ed3\u6784\u7684\u6742\u8d28\uff0c\u5e94\u5f53\u8fdb\u884c\uff08Q\uff09SAR\u9884\u6d4b\u548c\u4f53\u5185\u5916\u9057\u4f20\u6bd2\u6027\u548c\u81f4\u764c\u6027\u7814\u7a76\uff0c\u6216\u8005\u5c06\u6742\u8d28\u6c34\u5e73\u63a7\u5236\u5728\u6bd2\u7406\u5b66\u5173\u6ce8\u9608\uff08TTC\uff09\u4e4b\u4e0b\u3002<\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u76ee\u524d\uff0c\u4e00\u822c\u5c06\u81f4\u764c\u7269\u5206\u6210\u4e24\u5927\u7c7b\uff1a\u4e00\u7c7b\u662f\u9057\u4f20\u6bd2\u6027\u81f4\u764c\u7269\uff0c\u901a\u8fc7\u5316\u5b66\u952e\u5408\u76f4\u63a5\u7834\u574f\u9057\u4f20\u7269\u8d28\u4ea7\u751f\u81f4\u764c\u6027\uff0c \u5927\u591a\u6570\u7684\u5316\u5b66\u81f4\u764c\u7269\u5177\u6709\u9057\u4f20\u6bd2\u6027\uff1b \u7b2c\u4e8c\u7c7b\u662f\u975e\u9057\u4f20\u6bd2\u6027\u81f4\u764c\u7269\uff0c \u901a\u5e38\u4e0d\u4e0e\u53d1\u751f\u5316\u5b66\u952e\u5408\u4f5c\u7528\uff0c \u4e0d\u5bf9\u4ea7\u751f\u76f4\u63a5\u7834\u574f\uff0c \u800c\u662f\u901a\u8fc7\u9057\u4f20\u7269\u8d28\u5916\u7684\u95f4\u63a5\u673a\u5236\u5f15\u8d77\u81f4\u764c\u4f5c\u7528\uff08 \u5982\u4fc3\u8fdb\u7ec6\u80de\u8fc7\u5ea6\u589e\u6b96\u7b49\uff09\u3002<\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5c06\u591a\u4e2a\u6587\u732e\u4e2d\u7684\u8b66\u793a\u7ed3\u6784\u6c47\u603b\u4e8e\uff08\u89c1\u539f\u6587PDF\uff09\u3002\u5173\u4e8e\u57fa\u56e0\u6742\u8d28\u8b66\u793a\u7ed3\u679c\u7684\u5177\u4f53\u8be6\u7ec6\u4fe1\u606f\u53e6\u5916\u53ef\u53c2\u8003\u6b27\u76df\u53d1\u5e03\u7684\u8b66\u793a\u7ed3\u6784\u300aDevelopment of structure alerts for the in vivo micronucleus assay in rodents\u300b\u3002\u6216\u8fdb\u5165 The Carcinogenic Potency Database (CPDB)\uff0c\u91cc\u9762\u6709 1547 \u79cd\u81f4\u764c\u7269\u8d28\u7684\u5217\u8868\uff0c\u7ed3\u6784\u5f0f\uff0cCAS \u53f7\uff0c\u4f5c\u7528\u90e8\u4f4d\uff0cTTC \u503c\u7b49\u4e00\u7cfb\u5217\u4fe1\u606f\u3002\u5e94\u5f53\u6ce8\u610f\uff0c \u542b\u6709\u8b66\u793a\u7ed3\u6784\u5e76\u4e0d\u610f\u5473\u7740\u8be5\u6742\u8d28\u4e00\u5b9a\u5177\u6709\u9057\u4f20\u6bd2\u6027\uff0c \u800c\u786e\u8ba4\u6709\u9057\u4f20\u6bd2\u6027\u7684\u7269\u8d28\u4e5f\u4e0d\u4e00\u5b9a\u4f1a\u4ea7\u751f\u81f4\u764c\u4f5c\u7528\u3002\u6742\u8d28\u7684\u7406\u5316\u6027\u8d28\u548c\u5176\u4ed6\u7ed3\u6784\u7279\u70b9\uff08\u5982\u76f8\u5bf9\u5206\u5b50\u8d28\u91cf\u3001\u4eb2\u6c34\u6027\u3001\u5206\u5b50\u5bf9\u79f0\u6027 \/ \u7a7a\u95f4\u4f4d\u963b\u3001\u53cd\u5e94\u6d3b\u6027\u4ee5\u53ca\u751f\u7269\u4ee3\u8c22\u901f\u7387\u7b49\uff09\u4f1a\u5bf9\u5176\u6bd2\u6027\u4ea7\u751f\u6291\u5236\u6216\u8c03\u8282\u4f5c\u7528\u3002\u8b66\u793a\u7ed3\u6784\u7684\u91cd\u8981\u6027\u5728\u4e8e\u5b83\u63d0\u793a\u4e86\u53ef\u80fd\u5b58\u5728\u7684\u9057\u4f20\u6bd2\u6027\u548c\u81f4\u764c\u6027\uff0c \u4e3a\u8fdb\u4e00\u6b65\u7684\u6742\u8d28\u5b89\u5168\u6027\u8bc4\u4ef7\u548c\u63a7\u5236\u7b56\u7565\u7684\u9009\u62e9\u6307\u660e\u65b9\u5411\u3002<\/p>\n<p style=\"margin-top: 8px;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;widows: 1;height: 32px;color: rgb(0, 187, 236);line-height: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-bottom: 1px solid rgb(227, 227, 227);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;max-width: 100%;line-height: 28px;border-bottom: 2px solid rgb(51, 102, 153);float: left;display: block;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);background-color: rgb(51, 102, 153);box-sizing: border-box !important;word-wrap: break-word !important;\">4<\/span><\/span><span class=\"\" style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;max-width: 100%;color: rgb(38, 38, 38);line-height: 28px;border-bottom: 2px solid rgb(51, 102, 153);float: left;display: block;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong class=\"\" style=\"max-width: 100%;color: rgb(51, 102, 153);line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5bf9\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u7684\u6cd5\u89c4\u8981\u6c42\u53ca\u9650\u5ea6<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u6700\u521d\uff0cICH\u76f8\u7ee7\u63a8\u51fa\u7684\u539f\u6599\u836f\u6742\u8d28\u7814\u7a76\u6307\u5bfc\u539f\u5219Q3A\uff08R2\uff09\u3001\u5236\u5242\u6742\u8d28\u7814\u7a76\u6307\u5bfc\u539f\u5219 Q3B\uff08R2\uff09\uff0c\u5728\u8fd9\u4e9b\u6307\u5bfc\u539f\u5219\u4e2d\u63d0\u53ca\u201c\u5bf9\u4e8e\u80fd\u591f\u4ea7\u751f\u5f3a\u7684\u836f\u7406\u6d3b\u6027\u6216\u6bd2\u6027\u7684\u6f5c\u5728\u6742\u8d28\uff0c\u5373\u4f7f\u5176\u542b\u91cf\u4f4e\u4e8e0.1%\uff0c\u4ecd\u7136\u5efa\u8bae\u8fdb\u884c\u7ed3\u6784\u9274\u5b9a\u7814\u7a76\u201d\u3002\u5728\u4e4b\u540e\u7684\u4fee\u8ba2\u7248\u4e2d\uff0c\u8fd8\u8fdb\u4e00\u6b65\u660e\u786e\u201c\u8981\u5173\u6ce8\u539f\u6599\u836f\u4e2d\u7684\u6f5c\u5728\u9057\u4f20\u6bd2\u6027\u6742\u8d28\u201d\uff0c\u4ee5\u53ca\u201c\u5bf9\u4e8e\u6bd2\u6027\u975e\u5e38\u5f3a\u7684\u6742\u8d28\uff0c\u53ef\u80fd\u9700\u8981\u5236\u5b9a\u66f4\u4f4e\u7684\u9650\u5ea6\u201d\uff0c\u4f46\u662f\u5176\u4e2d\u5e76\u672a\u660e\u786e\u9610\u8ff0\u9057\u4f20\u6bd2\u6027\u6742\u8d28\u7684\u7814\u7a76\u548c\u63a7\u5236\u95ee\u9898\uff0c\u4e5f\u672a\u63d0\u51fa\u5177\u4f53\u7684\u7814\u7a76\u539f\u5219\u3001\u63a7\u5236\u7b56\u7565\u548c\u9650\u5ea6\u8981\u6c42\u3002<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5728EMA\uff08\u6b27\u6d32\u836f\u7269\u8bc4\u5ba1\u7ec4\u7ec7\uff09\u63a8\u51fa\u300a\u9057\u4f20\u6bd2\u6027\u6742\u8d28\u9650\u5ea6\u6307\u5bfc\u539f\u5219\u300b, \u5f15\u5165\u4e86\u53ef\u63a5\u53d7\u98ce\u9669\u7684\u6444\u5165\u91cf\uff0c\u5373\u6bd2\u6027\u7269\u8d28\u9650\u91cf\uff0c\u6216\u79f0\u6bd2\u7406\u5b66\u5173\u6ce8\u95e8\u69db\uff08TTC\uff0cThreshold of Toxicological Concern\uff09\u8fd9\u4e2a\u6982\u5ff5\u3002\u8bbe\u7f6e\u4e86\u9650\u5ea6\u503c TTC(1.5 \u00b5g\/day)\uff0c\u5373\u76f8\u5f53\u4e8e\u6bcf\u5929\u6444\u51651.5 \u00b5g\u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\uff0c\u88ab\u8ba4\u4e3a\u5bf9\u4e8e\u5927\u591a\u6570\u836f\u54c1\u6765\u8bf4\u662f\u53ef\u4ee5\u63a5\u53d7\u7684\u98ce\u9669\uff08\u4e00\u751f\u4e2d\u81f4\u764c\u7684\u98ce\u9669\u5c0f\u4e8e\u5341\u4e07\u5206\u4e4b\u4e00\uff09\u3002\u6309\u7167\u8fd9\u4e2a\u9608\u503c\uff0c\u53ef\u4ee5\u6839\u636e\u9884\u671f\u7684\u6bcf\u65e5\u6444\u5165\u91cf\u8ba1\u7b97\u51fa\u6d3b\u6027\u836f\u7269\u4e2d\u53ef\u63a5\u53d7\u7684\u6742\u8d28\u6c34\u5e73\u3002\u9700\u8981\u6307\u51fa\u7684\u662fTTC\u662f\u4e00\u4e2a\u98ce\u9669\u7ba1\u7406\u5de5\u5177\uff0c\u5b83\u91c7\u7528\u7684\u662f\u6982\u7387\u7684\u65b9\u6cd5\u3002\u5047\u5982\u6709\u4e00\u4e2a\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\uff0c\u5e76\u4e14\u6211\u4eec\u5bf9\u5b83\u7684\u6bd2\u6027\u5927\u5c0f\u4e0d\u592a\u4e86\u89e3\uff0c\u5982\u679c\u5b83\u7684\u6bcf\u65e5\u6444\u5165\u91cf\u4f4e\u4e8e TTC \u503c\uff0c\u90a3\u4e48\u5b83\u7684\u81f4\u764c\u98ce\u9669\u5c06\u4e0d\u4f1a\u9ad8\u4e8e10-5 \u7684\u6982\u7387\uff0cTTC\u4e0d\u80fd\u88ab\u7406\u89e3\u4e3a\u7edd\u5bf9\u65e0\u98ce\u9669\u7684\u4fdd\u969c\u3002\u5728\u7279\u5b9a\u7684\u6761\u4ef6\u4e0b\u4e00\u4e9b\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4e5f\u53ef\u4ee5\u6709\u8f83\u9ad8\u7684\u9608\u503c\u3002\u5982\u63a5\u89e6\u65f6\u95f4\u6bd4\u8f83\u77ed\u7b49\uff0c\u8fd9\u4e2a\u9700\u8981\u6839\u636e\u5b9e\u9645\u60c5\u51b5\u518d\u8fdb\u884c\u63a8\u7b97 \u3002\u6700\u8fd1\u51fa\u53f0\u7684ICH M7\u300aAssessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk\u300b\u4e2d\u8f83\u4e3a\u8be6\u5c3d\u7684\u9610\u660e\u4e86\u5982\u4f55\u4f7f\u7528TTC\u503c\uff0c\u5982\u4f55\u8bbe\u5b9a\u8d28\u91cf\u6807\u51c6\u3002\u4e0b\u9762\u5c31\u7b80\u8981\u4ecb\u7ecdICH M7\u6307\u5bfc\u539f\u5219\u4e2d\u7684\u5185\u5bb9\u3002<\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5df2\u7ecf\u5efa\u7acb\u7684TTC\u6982\u5ff5\uff0c\u7528\u4e8e\u754c\u5b9a\u6240\u6709\u672a\u7ecf\u7814\u7a76\uff0c\u4f46\u5177\u6709\u81f4\u764c\u98ce\u9669\u6216\u5176\u5b83\u6bd2\u6027\u6548\u679c\u7684\u5316\u5b66\u54c1\u7684\u53ef\u63a5\u53d7\u6444\u5165\u91cf\u3002\u57fa\u4e8eTTC\u7684\u65b9\u6cd5\u4e00\u822c\u88ab\u8ba4\u4e3a\u662f\u975e\u5e38\u4fdd\u5b88\u7684\uff0c\u56e0\u4e3a\u5b83\u4eec\u7275\u6d89\u5230\u4ece\u7ed9\u5b9a\u768450%\u80bf\u7624\u53d1\u751f\u7387\uff08TD50\uff09\u7b80\u5355\u7ebf\u6027\u5916\u63a8\u5230\u5341\u4e07\u5206\u4e4b\u4e00\u53d1\u751f\u7387\uff0c\u4e14\u91c7\u7528\u7684\u6570\u636e\u662f\u6765\u81ea\u4e8e\u6700\u654f\u611f\u7269\u79cd\u548c\u6700\u654f\u611f\u80bf\u7624\u90e8\u4f4d\u7684TD50\u6570\u636e\u3002\u5728\u4f7f\u7528TTC\u8bc4\u4f30\u539f\u6599\u836f\u548c\u5236\u5242\u4e2d\u8bf1\u53d8\u6027\u6742\u8d28\u7684\u53ef\u63a5\u7231\u6807\u51c6\u65f6\uff0c\u53ef\u4ee5\u91c7\u75281.5 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235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress7-1532674405.jpg\" alt=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\" title=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5e94\u91c7\u7528\uff08Q\uff09SAR \u65b9\u6cd5\u8fdb\u884c\u8ba1\u7b97\u5b66\u6bd2\u6027\u8bc4\u4f30\uff0c\u9884\u6d4b\u7ec6\u83cc\u8bf1\u53d8\u542b\u91cf\u7684\u7ed3\u679c\u3002\u8981\u4f7f\u7528\u4e24\u4e2a\u76f8\u4e92\u8865\u5145\u7684\uff08Q\uff09SAR 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style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5728ICH M7\u4e2d\uff0c\u9664\u4e86\u7ed9\u51fa\u8fd9\u56db\u79cd\u53c2\u8003\u63a7\u5236\u65b9\u6cd5\uff0c\u8fd8\u5bf9\u5177\u4f53\u7528\u54ea\u79cd\u65b9\u6cd5\uff0c\u5bf9\u54ea\u4e9b\u56e0\u7d20\u8fdb\u884c\u8003\u8651\uff0c\u4ee5\u53ca\u4e0a\u5e02\u7533\u62a5CTD\u9700\u8981\u63d0\u4f9b\u54ea\u4e9b\u4f9d\u636e\u6587\u4ef6\u7b49\uff0c\u7ed9\u51fa\u4e86\u4e00\u4e9b\u5177\u4f53\u8bf4\u660e\uff0c\u5728\u6b64\u5904\u4e0d\u518d\u7d2f\u8ff0\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"     style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532674405.jpg\" alt=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\" title=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u68c0\u6d4b\u51b3\u7b56\u6811<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-top: 8px;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;widows: 1;height: 32px;color: rgb(0, 187, 236);line-height: 18px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-bottom: 1px solid rgb(227, 227, 227);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;max-width: 100%;line-height: 28px;border-bottom: 2px solid rgb(51, 102, 153);float: left;display: block;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"margin-right: 8px;padding: 4px 10px;max-width: 100%;border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);background-color: rgb(51, 102, 153);box-sizing: border-box !important;word-wrap: break-word !important;\">3<\/span><\/span><span class=\"\" style=\"padding-right: 2px;padding-bottom: 3px;padding-left: 2px;max-width: 100%;color: rgb(38, 38, 38);line-height: 28px;border-bottom: 2px solid rgb(51, 102, 153);float: left;display: block;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong class=\"\" style=\"max-width: 100%;color: rgb(51, 102, 153);line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5982\u4f55\u68c0\u6d4b\u57fa\u56e0\u6bd2\u6027\u6742\u8d28<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5982\u524d\u7ae0\u6240\u8ff0\uff0c\u9488\u5bf9\u6742\u8d28\u7684\u4e0d\u540c\u6bd2\u6027\u3001\u670d\u836f\u671f\u957f\u77ed\u7b49\uff0c\u8bbe\u7f6e\u4e0d\u540c\u7684\u9608\u503c\uff0c\u5219\u9700\u8981\u76f8\u5e94\u4e0d\u540c\u68c0\u6d4b\u624b\u6bb5\uff0c\u5373\u5f00\u53d1\u62e5\u6709\u4e0d\u540c\u7684\u68c0\u6d4b\u9650\u7684\u5206\u6790\u65b9\u6cd5\u3002<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532674405.jpeg\" alt=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\" title=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u6c83\u7279\u4e16\u9488\u5bf9\u4e0d\u540c\u9650\u5ea6\u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u63d0\u4f9b\u4e0d\u540c\u7684\u89e3\u51b3\u65b9\u6848\uff0c\u6839\u636e\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u9650\u5ea6\u7684\u4e0d\u540c\uff0c\u53ef\u4ee5\u5206\u522b\u4f7f\u7528UPLC\/UV\uff0c2D UPLC\/UV \uff0cUPLC\/QDa\uff08\u5355\u56db\u6781\u6746\uff09\uff0cUPLC\/Xevo TQD\uff08\u4e09\u91cd\u56db\u6781\u6746\uff09\u3002\u4e0b\u9762\u5c31\u5206\u522b\u4ecb\u7ecd\u8fd9\u51e0\u79cd\u68c0\u6d4b\u624b\u6bb5\u7684\u7279\u70b9\uff1a<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section style=\"margin-top: 0.8em;margin-bottom: 0.5em;max-width: 100%;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;line-height: 27.2px;widows: 1;color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"padding: 0.3em 0.5em;max-width: 100%;display: inline-block;border-radius: 0.5em;color: white;text-align: center;font-size: 14px;box-shadow: rgb(165, 165, 165) 0.2em 0.2em 0.1em;background-color: rgb(51, 102, 153);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">UPLC\/UV\uff08\u8d85\u9ad8\u6548\u6db2\u76f8\u8272\u8c31\/ \u7d2b\u5916\u68c0\u6d4b\u5668\uff09\uff1a<\/strong><\/span><\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u76f8\u540c\u7684\u5316\u5408\u7269\uff0c\u4f7f\u7528UPLC\u4ee3\u66ffHPLC\uff0c\u4e0d\u4ec5\u68c0\u6d4b\u901f\u5ea6\u589e\u52a0\uff0c\u7075\u654f\u5ea6\u4e5f\u4f1a\u63d0\u5347\u597d\u51e0\u500d\uff0c\u6240\u4ee5\u4f7f\u7528UPLC\/UV\u5bf9\u5e38\u89c4\u9650\u5ea6\u8f83\u9ad8\u7684\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u90fd\u4f1a\u6709\u8f83\u597d\u7684\u6548\u679c\u3002<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5982\u4f7f\u7528UPLC\/UV \u65b9\u6cd5\u68c0\u6d4b\u82ef\u78fa\u9178\u6c28\u6c2f\u5730\u5e73\u6837\u54c1\u4e2d\u7684\u82ef\u78fa\u9178\u7532\u916f\uff08MBS\uff09\u548c\u82ef\u78fa\u9178\u4e59\u916f\uff08EBS\uff09\uff0c\u5728\u82ef\u78fa\u9178\u6c28\u6c2f\u5730\u5e73\u6837\u54c1\u4e2d\u52a0\u680715 ppm MBS\u548cEBS\u516d\u6b21\u8fdb\u6837\u7684\u53e0\u52a0\u8c31\u56fe\u3002<\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u53ef\u770b\u51fa\uff0c\u5bf9\u8fd9\u4e00\u7279\u5b9a\u6837\u54c1\uff0cUPLC\/UV\u68c0\u6d4b\u5373\u53ef\u8fbe\u5230FDA\u548cEMEA\u5bf9MBS\u548cEBS \u7684\u68c0\u6d4b\u6c34\u5e73\u8981\u6c42\u3002<\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5f53\u7136\uff0c\u4e0eUPLC\u76f8\u8fde\u7684\u68c0\u6d4b\u5668\u4e5f\u4e0d\u5c40\u9650\u4e8eUV\uff0c\u6839\u636e\u5316\u5408\u7269\u7279\u6027\uff0c\u5982\u5f85\u68c0\u6d4b\u6742\u8d28\u6709\u8367\u5149\u53d1\u8272\u57fa\u56e2\uff0c\u5219\u53ef\u4f7f\u7528\u8367\u5149\u68c0\u6d4b\u5668\u4e0e\u8d85\u9ad8\u6548\u6db2\u76f8\u8fde\u63a5\uff0c\u5f97\u5230\u8f83\u597d\u7684\u7075\u654f\u5ea6\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"     style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: 474px !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532674405-1.jpg\" alt=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\" title=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u7531HPLC\u8f6c\u5316\u6210UPLC\u65b9\u6cd5\uff0c\u68c0\u6d4b\u901f\u5ea6\u548c\u7075\u654f\u5ea6\u90fd\u4f1a\u5927\u5e45\u63d0\u5347<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"     style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532674405.jpg\" alt=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\" title=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u52a0\u680715 ppm\u82ef\u78fa\u9178\u7532\u916f\u548c\u82ef\u78fa\u9178\u4e59\u916f\u7684\u82ef\u78fa\u9178\u6c28\u6c2f\u5730\u5e73\u6837\u54c1\u7684UV\u5206\u6790<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section style=\"margin-top: 0.8em;margin-bottom: 0.5em;max-width: 100%;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;line-height: 27.2px;widows: 1;color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"padding: 0.3em 0.5em;max-width: 100%;display: inline-block;border-radius: 0.5em;color: white;text-align: center;font-size: 14px;box-shadow: rgb(165, 165, 165) 0.2em 0.2em 0.1em;background-color: rgb(51, 102, 153);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">2D UPLC\/UV\uff08\u4e8c\u7ef4\u8d85\u9ad8\u6548\u6db2\u76f8\u8272\u8c31\/ \u7d2b\u5916\u68c0\u6d4b\u5668\uff09\uff1a<\/strong><\/span><\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">2D UPLC\u7cfb\u7edf\u7531\u4e24\u4e2a\u6eb6\u5242\u7ba1\u7406\u5668\u3001\u4e00\u4e2a\u6837\u54c1\u7ba1\u7406\u5668\u3001\u4e00\u4e2a\u8272\u8c31\u67f1\u7ba1\u7406\u5668\u548c\u68c0\u6d4b\u5668\u5171\u540c\u7ec4\u6210\u3002\u5b83\u7684\u5e94\u7528\u5e7f\u6cdb\uff0c\u5728\u836f\u7269\u9886\u57df\u4e2d\uff0c\u6700\u5e38\u7528\u5230\u7684\u5373\u4e3a\u8fdb\u4e00\u6b65\u589e\u52a0\u5206\u79bb\u5ea6\u3001\u589e\u52a0\u7075\u654f\u5ea6\u7684\u529f\u80fd\u3002<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u4f7f\u7528UPLC\u4e8c\u7ef4\u6280\u672f\uff0c\u53ef\u4ee5\u901a\u8fc7\u589e\u5927\u8fdb\u6837\u91cf\u7684\u65b9\u5f0f\u6765\u63d0\u9ad8\u7075\u654f\u5ea6\u3002\u4f7f\u68c0\u6d4b\u9650\u5728UPLC\/UV\u7684\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u63d0\u5347\u3002<\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5728\u4e00\u7ef4\u4f53\u7cfb\u4e2d\uff0c\u5927\u4f53\u79ef\u8fdb\u6837\uff0c\u5e76\u5c06\u76ee\u6807\u6742\u8d28\u548cAPI\u6709\u6700\u57fa\u672c\u7684\u5206\u79bb\uff0c\u7136\u540e\u5c06\u76ee\u6807\u6742\u8d28\uff08\u4e0b\u56fe\u4e2d\u7eff\u8272\u90e8\u5206\uff09\u5207\u5165\u4e8c\u7ef4\u8fdb\u4e00\u6b65\u5206\u79bb\uff0c\u5f97\u5230\u65e0\u5e72\u6270\u7684\u76ee\u6807\u6742\u8d28\u5cf0\uff0c\u8fdb\u884c\u5b9a\u91cf\u66f4\u51c6\u786e\u3002\u4ece\u4e0b\u56fe\u7684\u5b9a\u91cf\u68c0\u6d4b\u7ed3\u679c\u53ef\u770b\u51fa\uff0c\u5373\u4f7f\u57285 ppm\u7684\u8f83\u4f4e\u542b\u91cf\u4e0b\uff0c\u4e5f\u6709\u8f83\u597d\u7684\u56de\u6536\u7387\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"     style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532674405.jpg\" alt=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\" title=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5927\u4f53\u79ef\u8fdb\u6837\u63d0\u9ad8\u7075\u654f\u5ea6\uff0c\u5c06\u7b2c\u4e00\u7ef4\u4e2d\u7eff\u8272\u90e8\u5206\u5207\u5165\u5230\u4e8c\u7ef4\u4f53\u7cfb\u4e2d<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"     style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: 470px !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532674406.jpg\" alt=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\" title=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5728\u4e8c\u7ef4\u4e2d\u8fdb\u4e00\u6b65\u5206\u79bb\u5e76\u5b9a\u91cf<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"     style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532674406.jpg\" alt=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\" title=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u4e8c<span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7ef4<\/span>\u4e2d\u6742\u8d28\u5b9a\u91cf\u7ed3\u679c<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section style=\"margin-top: 0.8em;margin-bottom: 0.5em;max-width: 100%;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;line-height: 27.2px;widows: 1;color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"padding: 0.3em 0.5em;max-width: 100%;display: inline-block;border-radius: 0.5em;color: white;text-align: center;font-size: 14px;box-shadow: rgb(165, 165, 165) 0.2em 0.2em 0.1em;background-color: rgb(51, 102, 153);box-sizing: border-box !important;word-wrap: break-word 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153);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">UPLC\/Xevo TQD\uff08\u8d85\u9ad8\u6548\u6db2\u76f8\/\u4e09\u91cd\u56db\u6781\u6746\u8d28\u8c31\u4eea\uff09\uff1a<\/strong><\/span><\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5f53\u8ffd\u6c42\u66f4\u4f4e\u7684\u68c0\u51fa\u9650\u65f6\uff0c\u5177\u4f53\u66f4\u9ad8\u7075\u654f\u5ea6\u7684\u4e09\u91cd\u56db\u6781\u6746\uff0c\u5e38\u5e38\u662f\u7528\u6237\u7684\u6700\u4f73\u9009\u62e9\u3002Waters\u6709\u591a\u79cd\u578b\u53f7\u7684\u4e09\u91cd\u56db\u6781\u6746\u53ef\u4f9b\u7528\u6237\u9009\u62e9\uff0c\u5f3a\u5927\u7a33\u5b9a\u4e14\u4e45\u7ecf\u9a8c\u8bc1\u7684Xevo 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!important;visibility: visible !important;width: auto !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532674406.jpg\" alt=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\" title=\"\u57fa\u56e0\u6bd2\u6027\u6742\u8d28\u4ecb\u7ecd\u53ca\u68c0\u6d4b\u65b9\u6cd5\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u4f7f\u7528UPLC\/Xevo TQD \u68c0\u6d4b0.1 ng\/mL \u7684\u7532\u78fa\u9178<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section style=\"margin-top: 0.8em;margin-bottom: 0.5em;max-width: 100%;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;line-height: 27.2px;widows: 1;color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"padding: 0.3em 0.5em;max-width: 100%;display: inline-block;border-radius: 0.5em;color: white;text-align: center;font-size: 14px;box-shadow: rgb(165, 165, 165) 0.2em 0.2em 0.1em;background-color: rgb(51, 102, 153);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">UPLC\/QTof\uff08\u8d85\u9ad8\u6548\u6db2\u76f8\/ \u98de\u884c\u65f6\u95f4\u8d28\u8c31\uff09\uff1a<\/strong><\/span><\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 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none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"margin-right: auto;margin-left: auto;padding: 0.5em 0em;max-width: 100%;width: 320px;overflow: hidden;border-radius: 5px;border-width: 1px;border-style: solid;border-color: rgb(200, 200, 200);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.5em;max-width: 100%;overflow: hidden;display: inline-block;vertical-align: bottom;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;vertical-align: top;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\">\u884c\u821fDrug<\/span><\/p>\n<\/section>\n<section style=\"padding-top: 0.3em;max-width: 100%;border-top: 1px dashed rgb(168, 164, 171);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;color: rgb(102, 102, 102);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\">\u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n<section  style=\"max-width: 100%;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;color: rgb(35, 21, 10);display: inline-block;width: 111.297px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;color: rgb(35, 21, 10);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;color: rgb(35, 21, 10);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\">\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u884c\u821fDrug                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u70b9\u51fb\u4e0a\u65b9\u7684&nbsp;\u884c\u821fDrug&nbsp;\u25b2&nbsp;\u6dfb\u52a0\u5173\u6ce8 1\u4ec0\u4e48\u662f\u57fa\u56e0\u6bd2\u6027\u6742\u8d28 \u57fa\u56e0\u6bd2\u6027\u6742\u8d28\uff08\u6216\u9057 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4539,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4538"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=4538"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4538\/revisions"}],"predecessor-version":[{"id":4551,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4538\/revisions\/4551"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/4539"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=4538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=4538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=4538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}