{"id":45458,"date":"2018-09-18T01:00:00","date_gmt":"2018-09-26T01:17:50","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e8%b0%83%e8%84%82%e8%8d%af%e7%89%a9%e4%b8%b4%e5%ba%8a%e7%a0%94%e5%8f%91%e5%92%8c%e8%af%84%e4%bb%b7%e8%a6%81%e7%b4%a0%e7%9a%84%e5%9f%ba%e6%9c%ac%e8%80%83%e8%99%91\/"},"modified":"2018-09-26T09:17:51","modified_gmt":"2018-09-26T01:17:51","slug":"%e8%b0%83%e8%84%82%e8%8d%af%e7%89%a9%e4%b8%b4%e5%ba%8a%e7%a0%94%e5%8f%91%e5%92%8c%e8%af%84%e4%bb%b7%e8%a6%81%e7%b4%a0%e7%9a%84%e5%9f%ba%e6%9c%ac%e8%80%83%e8%99%91","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/45458\/","title":{"rendered":"\u8c03\u8102\u836f\u7269\u4e34\u5e8a\u7814\u53d1\u548c\u8bc4\u4ef7\u8981\u7d20\u7684\u57fa\u672c\u8003\u8651"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537924671.jpeg\" alt=\"\u8c03\u8102\u836f\u7269\u4e34\u5e8a\u7814\u53d1\u548c\u8bc4\u4ef7\u8981\u7d20\u7684\u57fa\u672c\u8003\u8651\" title=\"\u8c03\u8102\u836f\u7269\u4e34\u5e8a\u7814\u53d1\u548c\u8bc4\u4ef7\u8981\u7d20\u7684\u57fa\u672c\u8003\u8651\"  \/><\/p>\n<section style=\"line-height: 2;letter-spacing: 1px;padding-right: 6px;padding-left: 6px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 90%;vertical-align: top;box-shadow: rgb(171, 171, 171) 0px 0px 5px;padding: 15px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: 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style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: 12%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 3px;margin-bottom: 3px;text-align: center;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(45, 69, 152);background-color: rgb(45, 69, 152);display: inline-block;width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 100%;margin-left: auto;margin-right: auto;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u4e00<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 88%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-right: 0%;margin-bottom: 5px;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;border-bottom: 1px dashed rgb(175, 175, 175);margin-bottom: 0.25em;padding-left: 5px;padding-right: 5px;color: rgb(45, 69, 152);text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8c03\u8102\u6cbb\u7597\u76ee\u6807\u53ca\u9776\u70b9<\/strong><\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 0.5em;height: 0.5em;border-radius: 50%;background-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: 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class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 10px 0%;box-sizing: border-box;text-align: justify;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: 12%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 3px;margin-bottom: 3px;text-align: center;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(45, 69, 152);background-color: rgb(45, 69, 152);display: inline-block;width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 100%;margin-left: auto;margin-right: auto;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u4e8c<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 88%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-right: 0%;margin-bottom: 5px;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;border-bottom: 1px dashed rgb(175, 175, 175);margin-bottom: 0.25em;padding-left: 5px;padding-right: 5px;color: rgb(45, 69, 152);text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 16px;\"><strong style=\"box-sizing: border-box;\">\u8c03\u8102\u836f\u7269\u4e34\u5e8a\u7814\u53d1\u6307\u5bfc\u539f\u5219\u63a2\u8ba8<\/strong><\/span><\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 0.5em;height: 0.5em;border-radius: 50%;background-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(45, 69, 152);box-sizing: border-box;\"><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">FDA\u66fe\u4e8e1990\u5e74\u53d1\u5e03\u4e86\u300a\u8840\u8102\u8c03\u8282\u836f\u7269\u4e34\u5e8a\u8bc4\u4ef7\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\uff0c\u540e\u4e8e2010\u5e744\u6708\u64a4\u56de\u8be5\u6587\u4ef6\u30021993\u5e74\uff0c\u6211\u56fd\u5f53\u65f6\u7684\u836f\u54c1\u7ba1\u7406\u673a\u6784-\u536b\u751f\u90e8\u836f\u653f\u53f8\u66fe\u7f16\u5236\u8fc7\u76f8\u5173\u8c03\u8102\u836f\u7814\u53d1\u6307\u5bfc\u539f\u5219\u3002\u76ee\u524dFDA\u53ca\u6211\u56fd\u5747\u672a\u53d1\u5e03\u65b0\u7684\u6307\u5bfc\u539f\u5219\u3002CHMP\u4e8e2005\u5e74\u53d1\u5e03\u4e86\u300a\u6cbb\u7597\u8102\u4ee3\u8c22\u7d0a\u4e71\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u6307\u5bfc\u539f\u5219\u300b\uff0c\u5e76\u5206\u522b\u4e8e2013\u5e74\u548c2016\u5e74\u66f4\u65b0\u3002\u4e0b\u9762\u4e3b\u8981\u53c2\u7167CHMP\u65b0\u7248\u8c03\u8102\u836f\u7269\u7814\u53d1\u6307\u5bfc\u539f\u5219\u8981\u70b9\uff0c\u7ed3\u5408\u5ba1\u8bc4\u5b9e\u8df5\uff0c\u5bf9\u76f8\u5173\u4e34\u5e8a\u8981\u7d20\u8fdb\u884c\u8ba8\u8bba\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(45, 69, 152);box-sizing: border-box;\"><\/span><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(45, 69, 152);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">1\u3001<\/strong><\/span><span style=\"color: rgb(45, 69, 152);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u53d7\u8bd5\u8005\u9009\u62e9<\/strong><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(45, 69, 152);box-sizing: border-box;\"><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">CHMP\u6307\u5bfc\u539f\u5219\u6709\u4ee5\u4e0b\u5efa\u8bae\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: rgb(45, 69, 152);border-radius: 100%;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">1<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"text-align: justify;clear: none;white-space: normal;box-sizing: 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border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"background-color: rgb(255, 255, 255);color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: initial;border-radius: 100%;text-align: center;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">2<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"text-align: justify;clear: none;white-space: normal;box-sizing: border-box;\">\u5bf9\u4e8e\u4ee5\u4e34\u5e8a\u7ed3\u5c40\u8bc4\u4ef7\u4e3a\u76ee\u6807\u7684\u8bd5\u9a8c\uff0c\u5e94\u6839\u636e\u5fc3\u8840\u7ba1\u7684\u603b\u4f53\u98ce\u9669\u9009\u62e9\u53d7\u8bd5\u4eba\u7fa4\u3002\u5e94\u5f53\u6709\u8db3\u591f\u6570\u91cf\u52a8\u8109\u7ca5\u6837\u786c\u5316\u548c\/\u62162\u578b\u7cd6\u5c3f\u75c5\u4e34\u5e8a\u8868\u73b0\u7684\u60a3\u8005\uff0c\u4ee5\u4fbf\u5206\u7ec4\u7edf\u8ba1\u5206\u6790\u3002\u8fd9\u4e9b\u7814\u7a76\u53ef\u80fd\u5305\u542b\u80c6\u56fa\u9187\u6c34\u5e73\u5904\u4e8e\u4e34\u754c\u6c34\u5e73\u751a\u6216\u6b63\u5e38\u7684\u60a3\u8005\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"background-color: rgb(255, 255, 255);color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: initial;border-radius: 100%;text-align: center;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">3<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"text-align: justify;clear: none;white-space: normal;box-sizing: border-box;\">\u5176\u5b83\u8102\u4ee3\u8c22\u7d0a\u4e71\u7c7b\u578b\u3002\u5982\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08\u6742\u5408\u5b50\u7a81\u53d8\u548c\u7eaf\u5408\u5b50\u7a81\u53d8\uff09\u7684\u60a3\u8005\uff0c\u4e00\u822c\u5e94\u5f53\u6839\u636e\u80c6\u56fa\u9187\u6c34\u5e73\u548c\u4e34\u5e8a\u9057\u4f20\u7279\u5f81\uff0c\u5728\u5355\u72ec\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u7814\u7a76\u3002\u8fd9\u4e5f\u9002\u7528\u4e8e\u5176\u4ed6\u8102\u4ee3\u8c22\u7d0a\u4e71\u7c7b\u578b\uff0c\u5305\u62ec\u5bb6\u65cf\u578b\u8840\u03b2\u8102\u86cb\u767d\u5f02\u5e38\u548c\u9ad8\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u7b14\u8005\u6709\u4ee5\u4e0b\u51e0\u70b9\u8003\u8651\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: rgb(45, 69, 152);border-radius: 100%;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">1<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u9274\u4e8e\u8c03\u8102\u6cbb\u7597\u4e3b\u8981\u76ee\u6807\u4e3a\u964d\u4f4e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\uff0c\u8c03\u8102\u548c\u964d\u4f4e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u4e0d\u53ef\u622a\u7136\u5206\u5f00\uff0c\u8c03\u8102\u4e0e\u964d\u4f4e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u56e0\u679c\u5173\u7cfb\u672a\u5efa\u7acb\u60c5\u51b5\u4e0b\uff0c\u4e0d\u63a8\u8350\u5355\u7eaf\u5c06\u964d\u8102\u6cbb\u7597\u4f5c\u4e3a\u6cbb\u7597\u76ee\u6807\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: rgb(45, 69, 152);border-radius: 100%;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">2<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u7eb3\u5165\u53d7\u8bd5\u8005\u65f6\uff0c\u8fd8\u5e94\u4ece\u65b0\u836f\u7814\u53d1\u7684\u4e34\u5e8a\u5b9a\u4f4d\u51fa\u53d1\uff0c\u8003\u8651\u836f\u54c1\u62df\u7528\u4e8e\u5fc3\u8840\u7ba1\u75be\u75c5\u4e00\u7ea7\u9884\u9632\u8fd8\u662f\u4e8c\u7ea7\u9884\u9632\u3001\u62df\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u6216\u8005\u4e8c\u7ebf\u6cbb\u7597\u4ee5\u53ca\u9884\u671f\u6cbb\u7597\u7684\u8102\u4ee3\u8c22\u7d0a\u4e71\u7c7b\u578b\u7b49\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: rgb(45, 69, 152);border-radius: 100%;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">3<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u9488\u5bf9\u4e0d\u540c\u5fc3\u8840\u7ba1\u98ce\u9669\u60a3\u8005\uff0c\u83b7\u76ca\/\u98ce\u9669\u8981\u6c42\u4e0d\u540c\uff0c\u8bd5\u9a8c\u8bbe\u8ba1\u65f6\u8981\u5145\u5206\u8003\u8651\u4e0d\u540c\u4eba\u7fa4\u4e4b\u95f4\u7597\u6548\u7ec8\u70b9\u9009\u62e9\u7684\u5dee\u5f02\u53ca\u5176\u4f9d\u636e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;color: rgb(18, 17, 17);box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(45, 69, 152);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">2\u3001\u836f\u7269\u6cbb\u7597<\/strong><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">CHMP\u6307\u5bfc\u539f\u5219\u5efa\u8bae\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"background-color: rgb(255, 255, 255);color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: initial;border-radius: 100%;text-align: center;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">1<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"text-align: justify;clear: none;white-space: normal;box-sizing: border-box;\">\u63a2\u7d22\u6027\u7814\u7a76\u4e00\u822c\u5e94\u8be5\u9075\u5faa\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u539f\u5219\uff0c\u4e14\u81f3\u5c11\u7814\u7a763\u79cd\u5242\u91cf\uff0c\u4ee5\u4fbf\u5efa\u7acb\u5242\u91cf-\u6548\u5e94\u5173\u7cfb\uff0c\u63a2\u7d22\u4e34\u5e8a\u6709\u6548\u7684\u5242\u91cf\u8303\u56f4\u53ca\u6700\u4f73\u5242\u91cf\u3002\u4e00\u822c\u91c7\u7528\u56fa\u5b9a\u5242\u91cf\u7684\u5e73\u884c\u7ec4\u8bbe\u8ba1\u65b9\u6cd5\u3002\u5242\u91cf\u7ec4\u7684\u8bbe\u7f6e\u5e94\u8be5\u80fd\u663e\u793a\u4e0d\u540c\u5242\u91cf\u4e4b\u95f4\u8c03\u8102\u6548\u5e94\u7684\u5dee\u522b\u3002\u6bcf\u4e2a\u5242\u91cf\u6c34\u5e73\u7684\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\u5e94\u5f53\u8db3\u591f\u957f\uff0c\u4ee5\u4fbf\u5176\u53d1\u6325\u6700\u5927\u7597\u6548\uff0c\u7136\u540e\u901a\u8fc7\u8bc4\u4f30\u786e\u5b9a\u662f\u5426\u8c03\u6574\u5242\u91cf\u3002\u7279\u6b8a\u60a3\u8005\u7684\u5242\u91cf\u8c03\u6574\u65b9\u6848\u5e94\u8be5\u6e05\u6670\u9610\u660e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"background-color: rgb(255, 255, 255);color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: initial;border-radius: 100%;text-align: center;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">2<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u786e\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e00\u822c\u9009\u62e9\u6807\u51c6\u6cbb\u7597\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\uff0c\u6216\u8005\u8bbe\u8ba1\u52a0\u8f7d\u8bd5\u9a8c\u3002\u5728\u540c\u7c7b\u836f\u7269\u95f4\u8fdb\u884c\u6bd4\u8f83\u65f6\uff0c\u5e94\u6ce8\u610f\u5bf9\u7167\u836f\u7684\u5242\u91cf\u662f\u5426\u5408\u9002\u3002\u5242\u91cf\u7684\u8c03\u6574\u987b\u6839\u636e\u5728\u76ee\u6807\u4eba\u7fa4\u4e2d\u8fdb\u884c\u7684\u5242\u91cf\u63a2\u7d22\u8bd5\u9a8c\u6765\u786e\u5b9a\u3002\u6b64\u5916\uff0c\u4f18\u5148\u9009\u62e9\u5df2\u663e\u793a\u4e34\u5e8a\u83b7\u76ca\u7684\u8c03\u8102\u836f\u7269\u8fdb\u884c\u6bd4\u8f83\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;color: rgb(18, 17, 17);box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7b14\u8005\u8ba4\u4e3a\uff0c\u76ee\u524d\u964d\u4f4eLDL-C\u836f\u7269\u4e3b\u8981\u5305\u62ec\u4ed6\u6c40\u4ee5\u53ca\u5728\u4ed6\u6c40\u57fa\u7840\u4e0a\u7684\u4f9d\u6298\u9ea6\u5e03\u6216\u8005PCSK9\u53d7\u4f53\u6291\u5236\u5242\u3002\u5728\u65b0\u836f\u4ec5\u7528\u4e8e\u4e0e\u73b0\u6709\u836f\u7269\u8054\u5408\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u76ee\u6807\u4eba\u7fa4\u5e94\u8be5\u7531\u4e0a\u5e02\u836f\u7269\u63a8\u8350\u5242\u91cf\u5355\u836f\u6cbb\u7597\u63a7\u5236\u8840\u8102\u4e0d\u8fbe\u6807\u7684\u60a3\u8005\u7ec4\u6210\uff0c\u4e0d\u5e94\u51cf\u5c11\u539f\u6807\u51c6\u6cbb\u7597\u836f\u7269\u5242\u91cf\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(45, 69, 152);box-sizing: border-box;\">3\u3001\u7814\u7a76\u5468\u671f<\/span><\/strong><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7814\u7a76\u5468\u671f\u7684\u8bbe\u5b9a\u5e94\u53d6\u51b3\u4e8e\u6cbb\u7597\u76ee\u6807\u3001\u5242\u91cf\u8c03\u6574\u65f6\u95f4\u548c\u6700\u4f73\u7597\u6548\u65f6\u95f4\u3002\u6839\u636eCHMP\u5efa\u8bae\uff0c\u5242\u91cf\u63a2\u7d22\u7814\u7a76\u5468\u671f\u4e00\u822c\u4ece4\u5468\u52303\u4e2a\u6708\u3002\u786e\u8bc1\u6027\u8bd5\u9a8c\u7684\u7814\u7a76\u5468\u671f\u4e00\u822c\u81f3\u5c113\u4e2a\u6708\uff08\u673a\u5236\u660e\u786e\uff09\u6216\u8005\u4e0d\u77ed\u4e8e12\u4e2a\u6708\uff08\u673a\u5236\u4e0d\u660e\u786e\uff09\u3002\u4e3a\u5145\u5206\u66b4\u9732\u957f\u671f\u5b89\u5168\u6027\u6548\u5e94\uff0c\u53d7\u8bd5\u8005\u4eba\u7fa4\u66b4\u9732\u65f6\u95f4\u81f3\u5c111\u5e74\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(45, 69, 152);box-sizing: border-box;\">4\u3001 \u7597\u6548\u8bc4\u4ef7<\/span><\/strong><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(45, 69, 152);box-sizing: border-box;\">4.1\u53d1\u75c5\u7387\u4e0e\u6b7b\u4ea1\u7387<\/span><\/strong><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u9488\u5bf9\u4ed6\u6c40\u7c7b\u8c03\u8102\u836f\u7269\uff0cLDL-C\u6c34\u5e73\u662f\u73b0\u9636\u6bb5\u516c\u8ba4\u7684\u66ff\u4ee3\u7ec8\u70b9\u3002\u9488\u5bf9LDL-C\u4ee5\u5916\u8840\u8102\u53c2\u6570\u7814\u53d1\u7684\u8c03\u8102\u836f\u54c1\uff0c\u4e00\u822c\u9700\u8981\u80fd\u591f\u8bc1\u5b9e\u5728\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u65b9\u9762\u5b58\u5728\u4e34\u5e8a\u83b7\u76ca\u3002\u4e00\u822c\u8ba4\u4e3a\uff0c\u4f5c\u7528\u4e8e\u65b0\u9776\u70b9\u7684\u975e\u4ed6\u6c40\u7c7b\u8c03\u8102\u836f\u7269\uff0c\u5373\u4f7f\u5176\u964d\u4f4e\u8840\u8102\u6210\u5206\u4e3aLDL-C\uff0c\u4ecd\u7136\u5efa\u8bae\u5728\u6ce8\u518c\u8bd5\u9a8c\u4e2d\u5c06\u5fc3\u8840\u7ba1\u4e8b\u4ef6\uff08CV\uff09\u4f5c\u4e3a\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u6216\u8005\u5173\u952e\u6b21\u8981\u7597\u6548\u7ec8\u70b9\uff0c\u6216\u8005\u81f3\u5c11\u6392\u9664\u65b0\u836f\u5176\u5bf9\u6b7b\u4ea1\u7387\u548c\u53d1\u75c5\u7387\u4ea7\u751f\u7684\u4e0d\u5229\u5f71\u54cd\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4f8b\u5982\uff0c\u5728Evolocumab\u6848\u4f8b\u4e2d\uff0c\u5728\u660e\u663e\u964d\u4f4eLDL-C\u6d53\u5ea6\u60c5\u51b5\u4e0b\uff0cFDA\u4ecd\u7136\u5bf9CV\u4e8b\u4ef6\u8fdb\u884c\u4e86\u4e00\u5b9a\u8981\u6c42\uff0c\u6700\u7ec8\u7ed3\u5408\u4f5c\u7528\u673a\u5236\u53ca\u4f9d\u6298\u9ea6\u5e03\u8bd5\u9a8c\u7ed3\u679c\uff0c\u624d\u83b7\u6279\u4e0a\u5e02\u3002\u57fa\u4e8ePCSK9\u6291\u5236\u5242\u7684\u6f5c\u5728\u4ef7\u503c\uff0c\u5df2\u6709\u4f01\u4e1a\u5728\u7814\u53d1PCSK9\u540c\u9776\u70b9\u54c1\u79cd\u3002\u56e0\u6b64\uff0c\u660e\u786e\u6b64\u7c7b\u8c03\u8102\u836f\u7269\u7814\u53d1\u8bc4\u4ef7\u7684\u903b\u8f91\u5c24\u4e3a\u91cd\u8981\u3002\u4e00\u822c\u6765\u8bb2\uff0c\u5982\u679c\u540c\u4e00\u7c7b\u8c03\u8102\u836f\u7269\u5728ASCVD\u98ce\u9669\u65b9\u9762\u663e\u793a\u51fa\u83b7\u76ca\u6216\u8005\u81f3\u5c11\u4e0d\u5b58\u5728\u635f\u5bb3\uff0c\u5e76\u4e14\u836f\u7269\u4e4b\u95f4\u4e0d\u592a\u53ef\u80fd\u5b58\u5728\u54c1\u79cd\u4e4b\u95f4\u7684\u660e\u663e\u5dee\u5f02\u53ca\u8131\u9776\u6548\u5e94\uff0c\u53ef\u51cf\u5c11\u5bf9\u53d1\u75c5\u7387\u4e0e\u6b7b\u4ea1\u7387\u4e34\u5e8a\u7ed3\u5c40\u7814\u7a76\u7684\u8981\u6c42\u3002\u4f46\u751f\u7269\u5236\u54c1\u5b58\u5728\u5176\u7279\u6b8a\u6027\u3002\u8f89\u745e\u8fd1\u671f\u5ba3\u5e03\u7ec8\u6b62\u5176\u5bf9PCSK9\u6291\u5236\u5242bococizumab\u7684\u7814\u53d1\uff0c\u7ed9\u4e86\u6211\u4eec\u4e00\u4e9b\u542f\u793a\u3002\u56e0\u6b64\uff0c\u9274\u4e8e\u751f\u7269\u7c7b\u5236\u54c1\u7684\u7279\u6b8a\u6027\uff0c\u9700\u8981\u57fa\u4e8e\u5177\u4f53\u54c1\u79cd\u751f\u7269\u5236\u5242\u7279\u5f81\u548c\u8bd5\u9a8c\u6570\u636e\uff0c\u6309\u521b\u65b0\u836f\u6216\u8005\u751f\u7269\u7c7b\u4f3c\u836f\u7406\u5ff5\u7814\u53d1\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(45, 69, 152);box-sizing: border-box;\">4.2 LDL-C\u6cbb\u7597\u76ee\u6807<\/span><\/strong><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">LDL-C\u6d53\u5ea6\u964d\u4f4e\u591a\u5c11\u5e45\u5ea6\u53ef\u652f\u6301\u836f\u54c1\u6ce8\u518c\uff0c\u56fd\u5185\u3001\u5916\u6307\u5bfc\u539f\u5219\u7684\u8981\u6c42\u5c1a\u4e0d\u4e00\u81f4\u3002FDA\u76841990\u7248\u300a\u8840\u8102\u8c03\u8282\u836f\u7269\u4e34\u5e8a\u8bc4\u4ef7\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u89c4\u5b9a\uff0c\u786e\u8bc1\u6027\u7814\u7a76\u7684\u7597\u6548\u8bc4\u4ef7\uff0c\u4e00\u822c\u8981\u6c42LDL-C \u4e0e\u57fa\u7ebf\u76f8\u6bd4\u81f3\u5c11\u670915%\u7684\u964d\u4f4e\u3002\u4f46\u662f\uff0c\u5728EMA\u76842005\u7248\u300a\u6cbb\u7597\u8102\u4ee3\u8c22\u7d0a\u4e71\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u6307\u5bfc\u539f\u5219\u8981\u70b9\u300b\u53ca\u51762013\u5e74\u30012016\u5e74\u4fee\u8ba2\u7248\u4e2d\uff0c\u5747\u672a\u5bf9LDL-C\u5177\u4f53\u964d\u4f4e\u5e45\u5ea6\u505a\u51fa\u5efa\u8bae\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7b14\u8005\u8ba4\u4e3a\uff0c\u57fa\u4e8e\u8c03\u8102\u6cbb\u7597\u76ee\u6807\u4ee5\u53ca\u65b0\u836f\u7814\u53d1\u548c\u8bc4\u4ef7\u9700\u6c42\uff0c\u4ecd\u5e94\u8003\u8651LDL-C\u7684\u6700\u4f4e\u964d\u4f4e\u5e45\u5ea6\u3002\u591a\u5e74\u6765\uff0c\u9664ACC\/AHA 2013\u5e74\u6210\u4eba\u80c6\u56fa\u9187\u6307\u5357\u672a\u8bbe\u7acbLDL-C\u6cbb\u7597\u7684\u9776\u76ee\u6807\u5916\uff0c\u56fd\u5185\u5916\u4e3b\u8981\u6cbb\u7597\u6307\u5357\u5747\u8bbe\u5b9a\u4e86LDL-C\u6cbb\u7597\u7684\u9776\u76ee\u6807\u6c34\u5e73\u3002\u6839\u636e\u8c03\u8102\u836f\u7269\u7684\u4e34\u5e8a\u5b9a\u4f4d\uff0c\u65b0\u836f\u7814\u53d1\u53ef\u5927\u81f4\u5206\u4e3a\u4e09\u7c7b\u60c5\u51b5\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"background-color: rgb(255, 255, 255);color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: initial;border-radius: 100%;text-align: center;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">1<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"text-align: justify;clear: none;white-space: normal;box-sizing: border-box;\">\u5355\u7528\u836f\u7269\uff0c\u5305\u62ec\u65b0\u7684\u4ed6\u6c40\u7c7b\u836f\u7269\u6216\u8005\u975e\u4ed6\u6c40\u7c7b\u836f\u7269\u3002\u57fa\u4e8e\u4ed6\u6c40\u7684\u7597\u6548\uff0c\u4e00\u822c\u4e0d\u63a8\u8350\u91c7\u7528\u975e\u4ed6\u6c40\u7c7b\u836f\u7269\u7684\u8d77\u59cb\u5355\u836f\u6cbb\u7597\u65b9\u6848\u3002\u6839\u636e\u4e2d\u56fd2016\u8840\u8102\u6cbb\u7597\u6307\u5357\uff0c\u5176\u5e38\u89c4\u5242\u91cf\uff08\u4e2d\u7b49\u5f3a\u5ea6\uff09\u964d\u8102\u5e45\u5ea6\u4e3a25-50%\u3002\u65b0\u7814\u53d1\u7684\u4ed6\u6c40\u7c7b\u836f\u7269\u6216\u8005\u5355\u7528\u7684\u975e\u4ed6\u6c40\u836f\u7269\u5e94\u8be5\u5728\u964d\u4f4eLDL-C\u6c34\u5e73\u4e0a\u4e0d\u52a3\u4e8e\u73b0\u6709\u4e0a\u5e02\u54c1\u79cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"background-color: rgb(255, 255, 255);color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: initial;border-radius: 100%;text-align: center;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">2<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"text-align: justify;clear: none;white-space: normal;box-sizing: border-box;\">\u52a0\u8f7d\u7c7b\u836f\u7269\u3002\u76ee\u524d\u591a\u6570\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5728\u5e38\u89c4\u4ed6\u6c40\u7c7b\u57fa\u7840\u4e0a\uff0c\u5c06\u8bd5\u9a8c\u836f\u4e0e\u5b89\u6170\u5242\u8fdb\u884c\u5bf9\u7167\uff0c\u4ee5\u671f\u8fbe\u5230\u964d\u4f4eLDL-C\u9776\u76ee\u6807\u3002\u4ece\u4e34\u5e8a\u4ef7\u503c\u8003\u8651\uff0c\u5982\u679c\u80fd\u591f\u5728\u6b64\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u964d\u4f4e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\uff0c\u4e5f\u53ef\u4ee5\u63a5\u53d7\u8f83\u4f4e\u7684\u964d\u8102\u5e45\u5ea6\u3002\u4f46\u6839\u636eIMPROVE-IT\u8bd5\u9a8c\u7ed3\u679c\uff0c\u964d\u4f4e\u5e45\u5ea6\u4f4e\u4e8e17%\u7684\u836f\u7269\uff0c\u8f83\u96be\u83b7\u5f97\u5fc3\u8840\u7ba1\u83b7\u76ca\u8bc1\u636e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: rgb(45, 69, 152);border-radius: 100%;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">3<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"text-align: justify;clear: none;white-space: normal;box-sizing: border-box;\">\u9488\u5bf9\u4ed6\u6c40\u4e0d\u8010\u53d7\u6216\u7279\u6b8a\u60a3\u8005\uff0c\u5982\u7eaf\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff0c\u8981\u57fa\u4e8e\u8c03\u8102\u6cbb\u7597\u76ee\u6807\uff0c\u4e0d\u52a3\u4e8e\u6216\u8005\u4f18\u4e8e\u73b0\u6709\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u517c\u987e\u5b89\u5168\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;color: rgb(45, 69, 152);box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">5\u3001\u5b89\u5168\u6027\u8bc4\u4ef7<\/strong><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(18, 17, 17);box-sizing: border-box;\">CHMP\u65b0\u7248\u6307\u5bfc\u539f\u5219\u5efa\u8bae\uff1a<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: rgb(45, 69, 152);border-radius: 100%;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">1<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u4e3a\u5145\u5206\u66b4\u9732\u5bf9\u4e8e\u6b7b\u4ea1\u7387\u548c\u5fc3\u8840\u7ba1\u53d1\u75c5\u7387\u7684\u957f\u671f\u6548\u5e94\uff0c\u53d7\u8bd5\u8005\u4eba\u7fa4\u66b4\u9732\u65f6\u95f4\u81f3\u5c111\u5e74\uff0c\u5e76\u5f3a\u8c03\u6700\u597d\u5728II\u671f\u9636\u6bb5\uff0c\u5c3d\u65e9\u5f00\u59cb\u6536\u96c6\u5b89\u5168\u6027\u4fe1\u606f\uff0c\u4ece\u4eba\u7fa4\u89c4\u6a21\u548c\u7814\u7a76\u65f6\u95f4\u4e24\u65b9\u9762\u786e\u4fdd\u836f\u7269\u66b4\u9732\u7684\u5145\u5206\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: rgb(45, 69, 152);border-radius: 100%;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">2<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u5728\u9488\u5bf9\u7279\u5b9a\u9776\u5668\u5b98\uff0c\u5982\u809d\u810f\u3001\u808c\u8089\u548c\u80be\u810f\u7684\u5b89\u5168\u6027\u76d1\u6d4b\u8fdb\u884c\u76f8\u5173\u5efa\u8bae\u7684\u540c\u65f6\uff0c\u8fd8\u65b0\u589e\u4e86\u5355\u4e2a\u5c0f\u8282\u5bf9\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u8fdb\u884c\u4e86\u8ba8\u8bba\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u65b0\u673a\u5236\u836f\u7269\u6216\u8005\u67d0\u7c7b\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u672a\u77e5\u548c\u5b58\u5728\u95ee\u9898\u7684\u836f\u54c1\uff0c\u5e94\u8be5\u5728\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5168\u9762\u7814\u7a76\u548c\u63cf\u8ff0\u5176\u98ce\u9669\u7279\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-left: 15px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 100%;box-sizing: border-box;\">\n<section style=\"border-left: 1px solid rgb(45, 69, 152);height: 1.2em;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<section style=\"color: rgb(45, 69, 152);font-size: 19px;display: inline-block;float: left;width: 1.33em;height: 1.33em;line-height: 1.33em;margin-left: -0.666em;border-width: 1px;border-style: solid;border-color: rgb(45, 69, 152);border-radius: 100%;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">3<\/p>\n<\/section>\n<section style=\"border-left: 1px solid rgb(45, 69, 152);width: 95%;border-top-color: rgb(45, 69, 152);border-right-color: rgb(45, 69, 152);border-bottom-color: rgb(45, 69, 152);box-sizing: border-box;\">\n<section style=\"padding-left: 5px;width: 94%;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u4e0d\u540c\u6027\u522b\u548c\u4e0d\u540c\u5e74\u9f84\u7ec4\u53d7\u8bd5\u8005\u4eba\u7fa4\u5e94\u6301\u7eed\u66b4\u9732\u4e8e\u836f\u7269\u81f3\u5c11\u4e00\u5e74\uff0c\u5e76\u5e94\u5f53\u4ee3\u8868\u4e86\u771f\u5b9e\u4e16\u754c\u4e2d\u7ecf\u5e38\u7ed9\u4e88\u8c03\u8102\u6cbb\u7597\u7684\u4e34\u5e8a\u75be\u75c5\uff0c\u5982\u7cd6\u5c3f\u75c5\u3001\u7f3a\u8840\u6027\u5fc3\u810f\u75c5\u548c\u9ad8\u8840\u538b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"color: rgb(18, 17, 17);text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0c\u5b89\u5168\u6027\u65b9\u9762\u9700\u8981\u5173\u6ce8\u4ee5\u4e0b\u51e0\u70b9\uff1a\u9996\u5148\uff0c\u56e0\u4ed6\u6c40\u7c7b\u836f\u7269\u4e0a\u5e02\u524d\u540e\u6570\u636e\u5747\u63d0\u793a\u5b58\u5728\u809d\u80be\u6bd2\u6027\uff0c\u540e\u7eed\u7814\u53d1\u9700\u5bf9\u6b64\u7279\u522b\u5173\u6ce8\u3002\u5176\u6b21\uff0c\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u808c\u75c5\u53ef\u80fd\u4e0d\u4ec5\u5b58\u5728\u4e8e\u4ed6\u6c40\u7c7b\u836f\u7269\u3002\u65b0\u8fd1\u7684GAUSS-3\u7814\u7a76\u63d0\u793a\uff0c\u4ed6\u6c40\u8010\u836f\u548c\u4e0d\u8010\u53d7\u7684\u53d7\u8bd5\u8005\u5728\u975e\u4ed6\u6c40\u7c7b\u836f\u7269\u8bd5\u9a8c\u65f6\uff0c\u808c\u75c5\u5e76\u4e0d\u5c11\u89c1\u3002\u6545\u9700\u5173\u6ce8\u8c03\u8102\u672c\u8eab\u4e0e\u808c\u75c5\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u7b2c\u4e09\uff0c\u5176\u5b83\u5173\u6ce8\u70b9\u8fd8\u5305\u62ec\u6781\u4f4e\u6c34\u5e73LDL-C\u7684\u957f\u671f\u5f71\u54cd\u548c\u8c03\u8102\u836f\u7269\u5bf9\u8840\u7cd6\u6c34\u5e73\u7684\u5f71\u54cd\u3002\u6b64\u5916\uff0c\u751f\u7269\u5236\u5242\u9700\u8981\u91cd\u70b9\u8003\u5bdf\u514d\u75ab\u6e90\u6027\u95ee\u9898\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7efc\u4e0a\uff0c\u4e34\u5e8a\u4ef7\u503c\u662f\u836f\u54c1\u7814\u53d1\u7684\u57fa\u7840\u3002\u8c03\u8282\u8840\u8102\u7684\u4e3b\u8981\u76ee\u6807\u662f\u964d\u4f4e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u3002LDL-C\u662f\u7ecf\u53cd\u590d\u9a8c\u8bc1\u7684\u6cbb\u7597\u9776\u70b9\uff0c\u8db3\u591f\u7684LDL-C\u6c34\u5e73\u964d\u4f4e\u5e45\u5ea6\uff0c\u662f\u5fc3\u8840\u7ba1\u83b7\u76ca\u7684\u5fc5\u8981\u4fdd\u969c\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;text-align: right;\"><span style=\"color: rgb(136, 136, 136);font-size: 15px;\">\uff08<span style=\"color: rgb(136, 136, 136);font-size: 15px;letter-spacing: 1px;text-align: right;\">\u4f9b\u7a3f\u4eba\uff1a<\/span><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: right;\"><span style=\"color: rgb(136, 136, 136);font-size: 15px;\">\u5316\u836f\u4e34\u5e8a\u4e8c\u90e8<\/span><span style=\"color: rgb(136, 136, 136);font-size: 15px;\">\u4e01\u53d1\u660e\u3001\u534e\u5c09\u5229\u3001\u738b\u6c34\u5f3a<\/span><span style=\"color: rgb(136, 136, 136);font-size: 15px;\">\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;text-align: center;box-sizing: border-box;\"><img     style=\"width: 100%;max-height: 1.2em !important;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537924671.png\" alt=\"\u8c03\u8102\u836f\u7269\u4e34\u5e8a\u7814\u53d1\u548c\u8bc4\u4ef7\u8981\u7d20\u7684\u57fa\u672c\u8003\u8651\" title=\"\u8c03\u8102\u836f\u7269\u4e34\u5e8a\u7814\u53d1\u548c\u8bc4\u4ef7\u8981\u7d20\u7684\u57fa\u672c\u8003\u8651\"  \/> <\/p>\n<section style=\"width: 0.6em;height: 0.6em;margin: -0.9em auto 0.9em;box-sizing: border-box;\">\n<section style=\"width: 100%;height: 100%;margin-left: 1px;border-radius: 100%;background-color: rgb(45, 69, 152);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\">\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u4e34\u5e8a\u7814\u7a76\u7684\u9010\u6b65\u8fdb\u5c55\uff0c\u5bf9\u8c03\u8102\u6cbb\u7597\u7684\u8ba4\u77e5\u4e0d\u65ad\u66f4\u65b0\u3002&nbsp;\u672c\u6587\u53c2\u7167\u56fd\u5185\u5916\u8c03\u8102\u836f\u7269\u7814\u53d1\u6307\u5bfc\u539f\u5219\uff0c\u7279\u522b 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