{"id":45573,"date":"2018-09-20T01:00:00","date_gmt":"2018-09-26T01:18:57","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e5%a6%82%e4%bd%95%e9%a2%84%e6%b5%8b%e3%80%81%e8%af%8a%e6%96%ad%e3%80%81%e9%a2%84%e9%98%b2%e5%92%8c%e6%b2%bb%e7%96%97%ef%bc%9f%e7%ad%94%e6%a1%88\/"},"modified":"2018-09-26T09:19:02","modified_gmt":"2018-09-26T01:19:02","slug":"%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e5%a6%82%e4%bd%95%e9%a2%84%e6%b5%8b%e3%80%81%e8%af%8a%e6%96%ad%e3%80%81%e9%a2%84%e9%98%b2%e5%92%8c%e6%b2%bb%e7%96%97%ef%bc%9f%e7%ad%94%e6%a1%88","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/45573\/","title":{"rendered":"\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5982\u4f55\u9884\u6d4b\u3001\u8bca\u65ad\u3001\u9884\u9632\u548c\u6cbb\u7597\uff1f\u7b54\u6848\u770b\u8fd9\u91cc"},"content":{"rendered":"
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\u56fe 1. \u75f4\u5446\u7684\u5168\u7403\u8d1f\u62c5\u548c\u6d41\u884c\u8d8b\u52bf<\/p>\n


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\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u98ce\u9669\u9884\u6d4b<\/strong><\/p>\n<\/section>\n<\/section>\n

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<\/p>\n

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\u5176\u4e2d\u7528\u4e8e\u4e2d\u5e74\u4eba\u7fa4\u98ce\u9669\u8bc4\u4f30\u7684 CAIDE\uff08Cardiovascular Risk Factors, Aging, and Dementia\uff09\u8bc4\u5206\uff0c\u7eb3\u5165\u4e86\u5e74\u9f84\u3001\u6027\u522b\u3001BMI \u6307\u6570\u3001\u80c6\u56fa\u9187\u6c34\u5e73\u3001\u6536\u7f29\u538b\u6c34\u5e73\u4ee5\u53ca\u4f53\u80b2\u953b\u70bc\u5f3a\u5ea6\u7b49\u56e0\u7d20\u8fdb\u884c\u75f4\u5446\u98ce\u9669\u9884\u6d4b\u3002\u5176\u51c6\u786e\u7387\u8f83\u9ad8\uff0c\u4e14\u5176\u9884\u6d4b\u51c6\u786e\u6027\u7ecf\u8fc7\u4e86\u5176\u4ed6\u961f\u5217\u7814\u7a76\u7684\u9a8c\u8bc1\u3002<\/p>\n


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\u56fe 2. CAIDE \u75f4\u5446\u98ce\u9669\u8bc4\u5206<\/p>\n


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\u7528\u4e8e\u8001\u5e74\u4eba\u7fa4\u7684 DRS \u75f4\u5446\u98ce\u9669\u8bc4\u5206\uff08The Dementia Risk Score\uff09\u901a\u8fc7\u5bf9\u5e74\u9f84\u3001\u6027\u522b\u3001BMI \u6307\u6570\u3001\u76f8\u5173\u836f\u7269\u670d\u7528\u60c5\u51b5\u4ee5\u53ca\u75c5\u53f2\u8fdb\u884c\u7efc\u5408\u5206\u6790\uff0c\u5bf9\u75f4\u5446\u98ce\u9669\u7684\u9884\u6d4b\u4e5f\u6709\u8f83\u9ad8\u7684\u51c6\u786e\u6027\u3002<\/p>\n


<\/p>\n

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\u56fe 3. \u75f4\u5446\u98ce\u9669\u7cbe\u51c6\u9884\u6d4b\u6a21\u578b<\/p>\n

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\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u65e9\u671f\u8bca\u65ad<\/strong><\/p>\n<\/section>\n<\/section>\n

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\u8bc1\u636e\u663e\u793a\uff0c\u7ea6\u4e09\u5206\u4e4b\u4e00\u7684\u75f4\u5446\u662f\u53ef\u4ee5\u9884\u9632\u7684\uff0c\u75f4\u5446\u7684\u65e9\u671f\u8bca\u65ad\u7a7a\u524d\u91cd\u8981\u3002\u800c\u4e14\u8fd1\u5e74\u8bb8\u591a AD \u9632\u6cbb\u836f\u7269\u4ee5\u53ca\u65e8\u5728\u6539\u5584 AD \u4e34\u5e8a\u75c7\u72b6\u7684\u65b0\u836f\u7684\u7814\u53d1\u5931\u8d25\uff0c\u4e5f\u4f7f\u5f97\u5bf9 AD \u65e9\u671f\u8bca\u65ad\u5730\u9700\u6c42\u8d8a\u6765\u8d8a\u8feb\u5207\u3002\u4e0b\u8868\u603b\u7ed3\u4e86\u5230\u76ee\u524d\u4e3a\u6b62 AD \u8bca\u65ad\u6807\u51c6\u7684\u6f14\u53d8\u3002<\/p>\n


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\u8868 1. AD \u8bca\u65ad\u6807\u51c6\u6f14\u53d8<\/p>\n

\"\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5982\u4f55\u9884\u6d4b\u3001\u8bca\u65ad\u3001\u9884\u9632\u548c\u6cbb\u7597\uff1f\u7b54\u6848\u770b\u8fd9\u91cc\"<\/p>\n

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<\/p>\n

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<\/p>\n

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\u56fe 4. \u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e34\u5e8a\u8fdb\u7a0b\u548c\u751f\u7269\u6807\u5fd7\u7269\u52a8\u6001\u6f14\u53d8<\/p>\n


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\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u6dc0\u7c89\u6837\u86cb\u767d\uff08Amyloid\uff09\uff08\u8111\u810a\u6db2\/PET\uff09\u6539\u53d8\u65e9\u5728\u4e34\u5e8a\u75c7\u72b6\u51fa\u73b0\u4e4b\u524d 15~20 \u5e74\u5c31\u5df2\u7ecf\u5f00\u59cb\u3002\u968f\u7740\u75be\u75c5\u7684\u8fdb\u5c55\uff0c\u9646\u7eed\u51fa\u73b0 tau\uff08\u8111\u810a\u6db2\/PET\uff09\u3001\u7a81\u89e6\u529f\u80fd\u5f02\u5e38\uff08FDG-PET\uff09\uff0c\u6d77\u9a6c\u7ed3\u6784\uff08MRI\uff09\u7b49\u6807\u8bb0\u7269\u5f02\u5e38\uff0c\u6700\u540e\u624d\u51fa\u73b0\u76f8\u5173\u7684\u4e34\u5e8a\u75c7\u72b6\u6539\u53d8\u3002<\/p>\n


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\u4eca\u5e74\uff0c\u57fa\u4e8e\u5916\u5468\u8840\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u65e9\u671f\u8bca\u65ad\u6807\u5fd7\u7269\u7814\u53d1\u7684\u7a81\u7834\u6027\u8fdb\u5c55\uff0c\u6781\u5927\u5730\u63d0\u9ad8\u4e86\u5176\u65e9\u671f\u8bca\u65ad\u7684\u53ef\u64cd\u4f5c\u6027\uff08Nature\uff0c 2018\uff09\u3002<\/p>\n

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\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u79d1\u5b66\u9884\u9632<\/strong><\/p>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n

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<\/p>\n

\"\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5982\u4f55\u9884\u6d4b\u3001\u8bca\u65ad\u3001\u9884\u9632\u548c\u6cbb\u7597\uff1f\u7b54\u6848\u770b\u8fd9\u91cc\"<\/p>\n

\u56fe 5. \u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e3b\u8981\u7684\u53ef\u8c03\u63a7\u98ce\u9669\u56e0\u7d20\u548c\u4fdd\u62a4\u56e0\u7d20<\/p>\n


<\/p>\n

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<\/p>\n

\"\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5982\u4f55\u9884\u6d4b\u3001\u8bca\u65ad\u3001\u9884\u9632\u548c\u6cbb\u7597\uff1f\u7b54\u6848\u770b\u8fd9\u91cc\"<\/p>\n

\u56fe 6 \u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4e09\u7ea7\u9884\u9632<\/p>\n


<\/p>\n

\uff081\uff09\u521d\u7ea7\u9884\u9632\uff1a\u9488\u5bf9\u6700\u65e9\u671f\u65e0\u75c5\u7406\u9636\u6bb5\u8fdb\u884c\u8d85\u65e9\u671f\u5e72\u9884\uff0c\u4ee5\u8c03\u8282 AD \u75c5\u7406\u7269\u8d28\u7684\u6b63\u5e38\u4ee3\u8c22\uff08\u5982\u51cf\u5c11 A\u03b242 \u4ea7\u751f\uff0c\u9884\u9632\u795e\u7ecf\u539f\u7ea4\u7ef4\u7f20\u7ed3\u7684\u5f62\u6210\uff09\uff1b<\/p>\n


<\/p>\n

\uff082\uff09\u4e8c\u7ea7\u9884\u9632\uff1a\u9488\u5bf9 AD \u4e34\u5e8a\u524d\u9636\u6bb5\uff08\u8be5\u671f A\u03b2\u4ee3\u8c22\u5df2\u7ecf\u51fa\u73b0\u5f02\u5e38\uff0c\u4f46\u5c1a\u672a\u51fa\u73b0\u8ba4\u77e5\u529f\u80fd\u635f\u5bb3\uff09\u8fdb\u884c\u65e9\u671f\u5e72\u9884\uff0c\u6291\u5236 A\u03b2\u6591\u5757\u7684\u805a\u96c6\uff0c\u964d\u4f4e\u795e\u7ecf\u53d8\u6027\u7684\u8fdb\u7a0b\uff1b<\/p>\n


<\/p>\n

\uff083\uff09\u4e09\u7ea7\u9884\u9632\uff1a\u9488\u5bf9 AD \u4e34\u5e8a\u671f\uff08MCI \u671f\u548c\u75f4\u5446\u671f\uff09\u8fdb\u884c\u4e2d\u665a\u671f\u5e72\u9884\uff0c\u4ee5\u5ef6\u7f13\u75f4\u5446\u7684\u51fa\u73b0\u6216\u8fdb\u5c55\u901f\u5ea6\u3002\u76ee\u524d\u8bc1\u636e\u8868\u660e\uff1a\u9488\u5bf9 AD \u4e34\u5e8a\u671f\u4eba\u7fa4\u7684\u7b2c\u4e09\u7ea7\u9884\u9632\u63aa\u65bd\u6536\u6548\u751a\u5fae\uff0c\u8fd9\u4e5f\u589e\u52a0\u4e86\u5e72\u9884\u5173\u53e3\u524d\u79fb\u7684\u5fc5\u8981\u6027\u548c\u8feb\u5207\u6027\u3002<\/p>\n


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\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u79d1\u5b66\u6cbb\u7597<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
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\n
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<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u867d\u7136\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u76ee\u524d\u5c1a\u65e0\u6cd5\u6cbb\u6108\uff0c\u4f46\u91c7\u53d6\u67d0\u4e9b\u836f\u7269\u6216\u975e\u836f\u7269\u624b\u6bb5\u53ef\u534f\u52a9\u4e34\u5e8a\u533b\u5e08\u6539\u5584\u60a3\u8005\u75c7\u72b6\uff0c\u56e0\u6b64\u60a3\u8005\u51fa\u73b0\u65e9\u671f\u75c7\u72b6\u65f6\u5e94\u79ef\u6781\u6c42\u533b\uff0c\u83b7\u5f97\u4e13\u4e1a\u7684\u6307\u5bfc\u3002<\/p>\n


<\/p>\n

\u76ee\u524d\u5df2\u6709 4 \u79cd\u836f\u7269\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7528\u4e8e\u6539\u5584\u4e34\u5e8a\u75c7\u72b6\uff0c\u5206\u522b\u662f\u80c6\u78b1\u916f\u9176\u6291\u5236\u5242\uff1a\u591a\u5948\u54cc\u9f50\u3001\u5361\u5df4\u62c9\u6c40\u3001\u52a0\u5170\u4ed6\u654f\u548c\u8c37\u6c28\u9178\u53d7\u4f53\u62ee\u6297\u5242\uff1a\u7f8e\u91d1\u521a\u3002<\/p>\n


<\/p>\n

\u8868 2. AD \u7684\u6cbb\u7597<\/p>\n

\"\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5982\u4f55\u9884\u6d4b\u3001\u8bca\u65ad\u3001\u9884\u9632\u548c\u6cbb\u7597\uff1f\u7b54\u6848\u770b\u8fd9\u91cc\"<\/p>\n

\u6ce8\u610f\uff1a\u4f7f\u7528\u836f\u7269\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8fc7\u7a0b\u4e2d\u5e94\u53ca\u65f6\u76d1\u6d4b\u836f\u7269\u7597\u6548\u53ca\u5b89\u5168\u6027\uff0c\u4e34\u5e8a\u533b\u751f\u5e94\u9488\u5bf9\u4e0d\u540c\u75be\u75c5\u9636\u6bb5\u53ca\u75c7\u72b6\u7684\u60a3\u8005\u5236\u5b9a\u4e2a\u4f53\u5316\u7528\u836f\u65b9\u6848\u3002
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\u524d\u666f\u5c55\u671b<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
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<\/p>\n

\u8fd1\u4e9b\u5e74\u6765\uff0c\u968f\u7740\u5404\u4e2a\u56fd\u5bb6\u5bf9\u75f4\u5446\u91cd\u89c6\u7a0b\u5ea6\u7684\u9010\u6e10\u63d0\u9ad8\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u65e9\u671f\u8bca\u65ad\u548c\u9632\u6cbb\u7814\u7a76\u7a81\u98de\u731b\u8fdb\u3002\u5728\u672a\u6765\uff0c\u6211\u4eec\u5c06\u8fce\u6765\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u7cbe\u51c6\u533b\u7597\u65f6\u4ee3\uff0c\u57fa\u4e8e\u4f53\u6db2\u751f\u7269\u6807\u5fd7\u7269\u548c\u5206\u5b50\u5f71\u50cf\u7684\u65e9\u671f\u8bca\u65ad\u6280\u672f\u5c06\u4f1a\u5f97\u5230\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u6781\u5927\u5730\u63a8\u52a8\u4e86\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u65e9\u671f\u9632\u6cbb\u836f\u7269\u548c\u975e\u836f\u7269\u7814\u53d1\u3001\u4e34\u5e8a\u8bd5\u9a8c\u548c\u4e34\u5e8a\u5b9e\u8df5\u3002
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u57fa\u4e8e\u8840\u6db2\u3001\u553e\u6db2\u548c\u5c3f\u6db2\u7b49\u975e\u4fb5\u5165\u3001\u6613\u64cd\u4f5c\u751f\u7269\u6807\u8bb0\u7269\u7684\u7814\u53d1\u5c06\u4e3a\u6211\u4eec\u63d0\u4f9b\u66f4\u591a\u65b9\u4fbf\u53ef\u884c\u7684\u65e9\u671f\u8bca\u65ad\u63aa\u65bd\u3002\u6b64\u5916\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u57fa\u56e0\u68c0\u6d4b\u82af\u7247\u6280\u672f\u7684\u4e34\u5e8a\u5e94\u7528\u5c06\u4f1a\u7ed9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u98ce\u9669\u9884\u6d4b\u5e26\u6765\u9769\u547d\u6027\u7684\u7a81\u7834\u3002<\/p>\n


<\/p>\n

\u8fd1\u4e9b\u5e74\u6765\uff0c\u8bf8\u591a\u5931\u8d25\u6848\u4f8b\u4f3c\u4e4e\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u836f\u7269\u7684\u7814\u53d1\u8499\u4e0a\u4e86\u9634\u5f71\u3002\u4f46\u662f\u4f34\u968f\u7740\u4f17\u591a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u9632\u6cbb\u9886\u57df\u65b0\u7684\u8fdb\u6b65\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u79d1\u5b66\u9632\u6cbb\u5de5\u4f5c\u5fc5\u5c06\u9010\u6e10\u8d70\u5411\u67f3\u6697\u82b1\u660e\u3002<\/p>\n


<\/p>\n

\u76ee\u524d\uff0c\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u836f\u7269\u79cd\u7c7b\u7e41\u591a\uff0c\u7279\u522b\u662f\u4ee5 Aducanumab \u4e3a\u4ee3\u8868\u7684 Amyloid \u9776\u5411\u6cbb\u7597\u836f\u7269\u548c\u4ee5\u300c\u7518\u9732\u5be1\u7cd6\u4e8c\u9178\uff08GV-971\uff09\u300d\u4e3a\u4ee3\u8868\u7684\u591a\u9776\u70b9\u5e72\u9884\u56fd\u4ea7\u6297\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u836f\u7269\u7684\u6210\u529f\u7814\u53d1\uff0c\u5f88\u503c\u5f97\u5927\u5bb6\u7684\u671f\u5f85\u3002<\/p>\n


<\/p>\n

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<\/p>\n

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<\/p>\n

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<\/p>\n

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<\/p>\n

\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span>
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\u6295\u7a3f\u53ca\u5408\u4f5c | wanghong@dxy.cn
\u9898\u56fe\u6765\u6e90 | shutterstock<\/span><\/p>\n

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1.     Hou XH, Feng L, Zhang C, Cao XP, Tan L, Yu JT. Models for predicting risk of dementia: a systematic review. J Neurol Neurosurg Psychiatry. 2018 Jun 28. pii: jnnp-2018-318212. doi: 10.1136\/jnnp-2018-318212. [Epub ahead of print]<\/p>\n


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2.     Li JQ, Tan L, Wang HF, Tan MS, Tan L, Xu W, Zhao QF, Wang J, Jiang T, Yu JT. Risk factors for predicting progression from mild cognitive impairment to Alzheimer’s disease: a systematic review and meta-analysis of cohort studies. J Neurol Neurosurg Psychiatry. 2016 May;87(5):476-84.<\/p>\n


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3.     Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R; Contributors. NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 2018 Apr;14(4):535-562.<\/p>\n


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4.     Nakamura A, Kaneko N, Villemagne VL, Kato T, Doecke J, Dor\u00e9 V, Fowler C, Li QX, Martins R, Rowe C, Tomita T, Matsuzaki K, Ishii K, Ishii K, Arahata Y, Iwamoto S, Ito K, Tanaka K, Masters CL, Yanagisawa K. High performance plasma amyloid-\u03b2 biomarkers for Alzheimer’s disease. Nature. 2018 Feb 8;554(7691):249-254.<\/p>\n


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5.     Xu W, Tan L, Wang HF, Jiang T, Tan MS, Tan L, Zhao QF, Li JQ, Wang J, Yu JT. Meta-analysis of modifiable risk factors for Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2015 Dec;86(12):1299-306.<\/p>\n


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6.     Wang J, Tan L, Yu JT. Prevention Trials in Alzheimer’s Disease: Current Status and Future Perspectives. J Alzheimers Dis. 2016;50(4):927-45.<\/p>\n


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7.     Wang J, Yu JT, Wang HF, Meng XF, Wang C, Tan CC, Tan L. Pharmacological treatment of neuropsychiatric symptoms in Alzheimer’s disease: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2015 Jan;86(1):101-9.<\/p>\n


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8.     Tan CC, Yu JT, Wang HF, Tan MS, Meng XF, Wang C, Jiang T, Zhu XC, Tan L. Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014;41(2):615-31.<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

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