{"id":4560,"date":"2018-07-03T01:00:00","date_gmt":"2018-07-27T06:53:31","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e6%9c%ac%e5%ba%94%e6%8f%90%e5%89%8d10%e5%b9%b4%e4%b8%8a%e5%b8%82%e7%9a%84pd-1%ef%bc%8c%e5%b0%b1%e8%bf%99%e6%a0%b7%e8%a2%ab%e6%90%81%e7%bd%ae%e4%ba%86\/"},"modified":"2018-07-27T14:53:34","modified_gmt":"2018-07-27T06:53:34","slug":"%e6%9c%ac%e5%ba%94%e6%8f%90%e5%89%8d10%e5%b9%b4%e4%b8%8a%e5%b8%82%e7%9a%84pd-1%ef%bc%8c%e5%b0%b1%e8%bf%99%e6%a0%b7%e8%a2%ab%e6%90%81%e7%bd%ae%e4%ba%86","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/4560\/","title":{"rendered":"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86……"},"content":{"rendered":"
\n

\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug <\/span>\u25b2 \u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/p>\n


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<\/span>2014<\/span>\u5e74<\/span>7<\/span>\u6708<\/span>\u5168\u7403\u9996\u4e2aPD-1\u6291\u5236\u5242OPDIVO\u5728\u65e5\u672c\u4e0a\u5e02\uff0c\u4e4b\u540e\u514d\u75ab\u6291\u5236\u5242\u7684\u7814\u7a76\u70ed\u6f6e\u4fbf\u4e00\u53d1\u4e0d\u53ef\u6536\u62fe\u3002\u719f\u6089\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u670b\u53cb\u4f1a\u77e5\u9053\uff0cCTLA-4\u6291\u5236\u5242Yervoy\u00ae\u624d\u662f\u5168\u7403\u9996\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\u836f\u7269\u3002\u804a\u8d77CTLA-4\u6291\u5236\u5242Yervoy\u00ae\uff0c\u53ef\u4ee5\u8bf4\u5168\u662f\u773c\u6cea\uff0c\u5982\u679c\u5f53\u5e74BMS\u6ca1\u6709\u5ef6\u7f13CTLA-4\u7684\u836f\u7269\u7814\u53d1\uff0c\u6216\u8bb8PD-1\u6291\u5236\u5242OPDIVO\u65e910\u5e74\u5c31\u4e0a\u5e02\u4e86\u3002\u6545\u4e8b\u662f\u8fd9\u6837\u8bf4\u7684\uff1a<\/span><\/span><\/span><\/p>\n<\/section>\n<\/section>\n


<\/section>\n

<\/section>\n<\/section>\n<\/section>\n


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\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/p>\n


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1<\/strong><\/span>\u514d\u75ab\u6291\u5236\u5242\u524d\u4e16\u4e0e\u4eca\u751f<\/strong><\/span><\/span><\/h2>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/span><\/p>\n

\u6cd5\u56fd\u4ebaPierre Goldstein\u57281987\u5e74\u65e0\u610f\u4e2d\u53d1\u73b0\u4e86T\u7ec6\u80de\u4e0a\u7684\u4e00\u4e2a\u5206\u5b50CTLA-4\uff0c\u8d77\u521d\u5927\u5bb6\u5bf9\u8fd9\u4e00\u5206\u5b50\u5e76\u4e0d\u5728\u610f\uff0c\u4e00\u76f4\u52301994\u5e74UCSF\u7684JeffreyBluestone\u53d1\u73b0\u8fd9\u4e00\u86cb\u767d\u8ddf\u5df2\u7ecf\u53d1\u73b0\u4e86n\u591a\u5e74\u7684\u5171\u6fc0\u6d3b\u5206\u5b50CD28\u662f\u8d77\u76f8\u53cd\u4f5c\u7528\u7684\u3002\u4e0d\u8fc7\u4ed6\u4eec\u90fd\u662f\u7eaf\u514d\u75ab\u5b66\u5bb6\uff0c\u4e0d\u662f\u80bf\u7624\u4e13\u5bb6\uff0c\u6ca1\u5f80\u80bf\u7624\u514d\u75ab\u65b9\u5411\u53bb\u60f3\uff0c\u800c\u539f\u5148\u5728\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u7136\u540e\u53c8\u632a\u53bb\u7ebd\u7ea6\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u7684James Allison\u6559\u6388\u5374\u654f\u9510\u5730\u610f\u8bc6\u5230CTLA-4\u53ef\u80fd\u5728\u80bf\u7624\u514d\u75ab\u91cc\u5177\u6709\u201c\u975e\u540c\u51e1\u54cd\u201d\u7684\u529f\u80fd\uff0cAllison\u53d1\u73b0\u901a\u8fc7\u6291\u5236\u8fd9\u4e2aCTLA-4\uff0c\u5b83\u80fd\u5728\u52a8\u7269\u80bf\u7624\u6a21\u578b\u8d77\u5230\u67d0\u79cd\u7a0b\u5ea6\u7684\u6291\u5236\u80bf\u7624\u4f5c\u7528\uff0c\u4e8e\u662fCTLA-4\u4e5f\u5c31\u6210\u4e3a\u4e86\u7b2c\u4e00\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\u86cb\u767d\u5206\u5b50\u3002\u800cJames Allison\u7b97\u662f\u5f00\u542f\u4e86\u901a\u8fc7\u6291\u5236\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u9014\u5f84\u6765\u6cbb\u7597\u764c\u75c7\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b0\u7bc7\u7ae0<\/span>\uff08<\/strong>\u518d\u63d2\u4e00\u4e0b\uff0c\u6240\u4ee5Allison\u662f\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u6700\u5148\u7684\u5148\u9a71\uff0c\u4f30\u8ba1\u5f88\u5927\u53ef\u80fd\u4f1a\u62ff<\/strong><\/span>\u8bfa\u8d1d\u5c14\u5956\uff09\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/p>\n


<\/span><\/p>\n

BMS\u5f00\u59cb\u7814\u7a76CTLA-4\u86cb\u767d\u5206\u5b50\u5bf9\u6297\u764c\u75c7\u7684\u5f71\u54cd\uff0c\u53ef\u60dc\u540e\u6765\u4ed6\u4eec\u53d1\u73b0\u8fd9\u53ea\u662f\u4e00\u70b9\u66d9\u5149\u800c\u5df2\uff0c\u56e0\u4e3a\u8fd9\u4e2a\u5206\u5b50\u662f\u5728T\u7ec6\u80de\u4e0a\uff0c\u800c\u5176\u914d\u4f53\uff08ligand\uff09\u5e76\u4e0d\u5177\u5907\u80bf\u7624\u7279\u5f02\u6027\uff0c\u963b\u65adCTLA-4\u4f1a\u6fc0\u6d3b\u5168\u8eab\u514d\u75ab\u7cfb\u7edf\uff0c\u526f\u4f5c\u7528\u592a\u5f3a\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u8fd9\u65f6\u5019\u9057\u61be\u7684\u4e8b\u60c5\u53d1\u751f\u4e86\uff0cBMS\u516c\u53f8\u5728\u6295\u5165\u514d\u75ab\u7597\u6cd5\u7814\u53d1\u65b9\u5411\u8fd1\u5341\u5e74\u4e4b\u540e\u5931\u53bb\u4e86\u8010\u5fc3\uff0c\u56e0\u4e3a\u770b\u4e0d\u5230\u5927\u7684\u5e0c\u671b\uff0c\u4e8e1997\u5e74\u51b3\u5b9a\u5c06\u897f\u96c5\u56fe\u7814\u53d1\u90e8\u95e8\u5173\u6389\u3002<\/span>\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u8bf4\uff0cBMS\u516c\u53f8\u5f53\u5e74\u5bf9\u8fd9\u4e00\u65b9\u5411\u7684\u4e0d\u91cd\u89c6\uff0c\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u662f\u62d6\u5ef6\u4e86\u514d\u75ab\u68c0\u67e5\u70b9\u836f\u7269\u7684\u5f00\u53d1\uff0c\u5426\u5219\u8fd9\u4e00\u7c7b\u836f\u7269\u53ef\u80fd\u4f1a\u65e9\u4e2a10\u5e74\u95ee\u4e16\u3002<\/span><\/p>\n


<\/span><\/p>\n

 \"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/span><\/p>\n


<\/span><\/p>\n

\u4e0d\u8fc7\u597d\u5728\u79d1\u5b66\u5bb6\u9646\u7eed\u53d1\u73b0\u7684\u8fd1\u5341\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\uff0c\u53d1\u73b0\u4e86\u771f\u6b63\u5177\u6709\u80bf\u7624\u7279\u5f02\u6027\u7684\u4e00\u4e2a\u86cb\u767d\u5206\u5b50\uff0c\u4e5f\u5c31\u662f\u73b0\u5728\u95fb\u540d\u5929\u4e0b\u7684PD-1\uff0c\u4ece\u800c\u6380\u8d77\u4e86\u9a8c\u8bc1\u901a\u8fc7\u6291\u5236PD-1\uff08\u6216\u8005PD-L1\uff09\u662f\u5426\u80fd\u6297\u764c\u7684\u7814\u7a76\u65b0\u65b9\u5411\u3002<\/span>2009\u5e74\uff0cBMS\u901a\u8fc7\u6536\u8d2dMedarex\u83b7\u5f97\u4e86ipilimumab<\/strong>\u3002\u6700\u7ec8\uff0c<\/span>\u7f8e\u56fd<\/span>FDA<\/span>\u4e8e<\/span>2011<\/span>\u5e74<\/span>3<\/span>\u6708<\/span>25<\/span>\u65e5\u6279\u51c6<\/span>ipilimumab<\/span>\uff08\u5546\u6807\u540d\u79f0\u4e3a<\/span>Yervoy<\/span>\uff09\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/span><\/span><\/p>\n


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2<\/strong><\/span>PD-1\u8fc5\u901f\u706b\u904d\u5168\u7403<\/strong><\/span><\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

<\/span><\/span><\/p>\n

\u76ee\u524d\u5168\u7403\u4e0a\u5e02\u76845\u4e2a PD-1\/PD-L1\u6291\u5236\u5242\u5747\u5c5e\u4e8e\u5927\u5206\u5b50\u6297\u4f53\u7c7b\u836f\u7269\u3002\u6700\u4eae\u773c\u7684\u5f53\u5c5e\u7f8e\u65bd\u8d35\u5b9d(BMS) \u516c\u53f8\u7684 Opdivo\uff0c2016\u5e74\u5df2\u8fbe\u5230 46 \u4ebf\u7f8e\u5143\u7684\u9500\u552e\u989d\u3002\u9884\u8ba12020\u5e74\u6574\u4e2aPD-1\/PD-L1\u7c7b\u836f\u7269\u5e02\u573a\u9700\u6c42\u5c06\u8d85\u8fc7\u6570\u767e\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

<\/span><\/p>\n

\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/span><\/p>\n


<\/p>\n

\u4ece\u9500\u552e\u6536\u5165\u4e0a\u770b\uff0cPD-1\/PD-L1\u836f\u7269\u7684\u5168\u7403\u5e02\u573a\u89c4\u6a21\u53ea\u7528\u4e863\u5e74\u65f6\u95f4\u5c31\u6269\u5f20\u5230\u4e86\u8d85\u8fc7100\u4ebf\u7f8e\u5143\uff0c\u589e\u957f\u6781\u5176\u8fc5\u731b\u3002\u4ee5PD-1\u4e3a\u4ee3\u8868\u7684\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u76ee\u524d\u5df2\u7ecf\u6210\u4e3a\u80bf\u7624\u4e34\u5e8a\u6cbb\u7597\u7684\u6838\u5fc3\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n


<\/p>\n

PD-1\/PD-L1\u836f\u7269\u5386\u5e74\u5168\u7403\u9500\u552e\u989d\uff08\u4ebf\u7f8e\u5143\uff09<\/span><\/p>\n

\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/p>\n


<\/p>\n

\n

Opdivo<\/strong><\/span><\/p>\n<\/blockquote>\n

 <\/p>\n

Opdivo\u6700\u65e9\u4e8e2014\u5e747\u6708\u5728\u65e5\u672c\u83b7\u5f97\u6279\u51c6\uff0c\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684PD-1\/PD-L1\u7c7b\u836f\u7269\u30022014\u5e7412\u6708\uff0cOpdivo\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u867d\u7136\u6bd4Keytruda\u665a\u4e86\u5927\u7ea63\u4e2a\u6708\uff0c\u4f46\u662f\u51ed\u501f\u524d\u671f\u5728\u80ba\u764c\u9002\u5e94\u75c7\u4e0a\u7684\u4f18\u52bf\uff0c\u5e02\u573a\u4efd\u989d\u4e0a\u4e00\u76f4\u9886\u5148Keytruda\u3002<\/span><\/p>\n


<\/p>\n

\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/p>\n


<\/p>\n

\n

Keytruda<\/span><\/strong><\/p>\n<\/blockquote>\n


<\/span><\/p>\n

Keytruda\u7531\u9ed8\u6c99\u4e1c\u516c\u53f8\u5f00\u53d1\uff0c\u662f\u7f8e\u56fdFDA\u6279\u51c6\u7684\u7b2c\u4e00\u4e2aPD-1\u514d\u75ab\u68c0\u6d4b\u70b9\u6291\u5236\u5242\u30022015\u5e74\uff0c\u7f8e\u56fd\u524d\u603b\u7edf\u5361\u7279\u665a\u671f\u9ed1\u8272\u7d20\u7624\u5728Keytruda\u7684\u4f5c\u7528\u4e0b\uff0c\u795e\u5947\u6d88\u5931\uff1b\u5728\u4eca\u5e74\u7ed3\u675f\u7684\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0cKeytruda\u66f4\u662f\u5c55\u73b0\u4e86\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u7684\u6f5c\u529b\u3002<\/span><\/p>\n

 <\/p>\n

\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/p>\n

 
<\/p>\n

\n

Tecentrip<\/span><\/strong><\/span><\/p>\n<\/blockquote>\n


<\/p>\n

\u7f57\u6c0f\u7684Tecentrip\uff08Atezolizumab\uff09\u4e8e2016\u5e745\u6708\u83b7\u6279\u7528\u4e8e\u5c3f\u8def\u4e0a\u76ae\u764c\uff08\u8180\u80f1\u764c\uff09\uff0c\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7684PD-L1\u6291\u5236\u5242\u30022016\u5e7410\u6708\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u9776\u5411\u836f\u3001\u5316\u7597\u5931\u8d25\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002<\/span><\/p>\n


<\/p>\n

\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/p>\n


<\/p>\n

<\/span><\/p>\n

\n

Bavencio<\/span><\/strong><\/p>\n<\/blockquote>\n


<\/p>\n

2017\u5e743\uff0c\u7f8e\u56fdFDA\u5ba3\u544a\u540c\u610f\u7531\u5fb7\u56fd\u9ed8\u514b\u516c\u53f8\u4e0e\u8f89\u745e\u4e00\u8d77\u7814\u5236\u7684\u514d\u75ab\u7597\u6cd5\u65b0\u836fBavencio\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u6885\u514b\u5c14\u7ec6\u80de\u764c\uff08MMC\uff0c\u4e00\u79cd\u7a00\u6709\u80bf\u7624\uff09, Bavencio\u6210\u4e3a\u5168\u7403\u7b2c\u56db\u4e2aPD-1\/PD-L1\u6297\u4f53\u836f\u7269\u3002<\/span><\/p>\n

<\/span><\/p>\n

\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/p>\n

<\/span><\/p>\n

\n

Imfinzi<\/span><\/strong><\/span><\/p>\n<\/blockquote>\n

2017\u5e745\u6708\uff0cPD-1\/PD-L1\u6291\u5236\u5242\u7ade\u6280\u573a\u8fce\u6765\u4e86\u7b2c\u4e94\u540d\u73a9\u5bb6\uff0c\u963f\u65af\u5229\u5eb7PD-L1\u5355\u6297Imfinzi \u83b7\u5f97\u7f8e\u56fdFDA\u52a0\u901f\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u3002<\/span><\/p>\n

\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/p>\n


<\/span><\/span><\/p>\n

3<\/strong><\/span>\u56fd\u5185PD-1\u7ade\u4e89\u6fc0\u70c8<\/strong><\/span><\/h2>\n


<\/span><\/p>\n

2018\u5e746\u670815\u65e5\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9dPD-1\u5355\u6297\u836f\u7269Opdivo\u7684\u4e2d\u56fd\u4e0a\u5e02\u7533\u8bf7\u6b63\u5f0f\u83b7\u5f97CFDA\u6279\u51c6\u3002\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff01<\/span>\u76ee\u524d\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u7684PD-1\/PD-L1\uff0c\u53e6\u67094\u5bb6\u7533\u62a5\u4e0a\u5e02\uff1a\u5206\u522b\u4e3a\u541b\u5b9e\u751f\u7269\u7684\u7279\u745e\u666e\u5229\u5355\u6297\uff08JS001\uff09\u3001\u4fe1\u8fbe\u751f\u7269\u7684IBI308\u3001\u6052\u745e\u533b\u836f\u7684camrelizumab\u4ee5\u53ca\u9ed8\u6c99\u4e1c\u7684Keytruda\u3002<\/span>
<\/p>\n


<\/span><\/p>\n

\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/p>\n


<\/p>\n

\u4fe1\u8fbePD-1<\/span><\/strong><\/p>\n


<\/p>\n

2018\u5e744\u670819\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u91cd\u65b0\u63d0\u4ea4\u7684PD-1\u5355\u6297\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2<\/strong>\u7684\u4e0a\u5e02\u7533\u8bf7\uff08CXSS1800008\uff09\u6b63\u5f0f\u83b7\u5f97\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u627f\u529e\u53d7\u7406\u3002<\/span><\/p>\n


<\/p>\n

\"\u672c\u5e94\u63d0\u524d10\u5e74\u4e0a\u5e02\u7684PD-1\uff0c\u5c31\u8fd9\u6837\u88ab\u6401\u7f6e\u4e86......\"<\/p>\n


<\/p>\n

\u53e6\u5916\uff0c\u4fe1\u8fbe\u751f\u7269\u4f7f\u7528\u4fe1\u8fea\u5229\u5355\u6297\u7684\u56fd\u5185\u4e34\u5e8a\u6570\u636e\u5411FDA\u63d0\u4ea4\u4e86\u7f8e\u56fd\u65b0\u836f\u4e34\u5e8a\u7814\u7a76\u7533\u8bf7\uff08IND\uff09\uff0c\u5df2\u7ecf\u83b7\u5f97FDA\u7684\u4e34\u5e8a\u8bb8\u53ef\uff0c\u5e76\u4e14\u51c6\u8bb8\u8dc3\u8fc7I\u671f\u4e34\u5e8a\u76f4\u63a5\u8fdb\u5165\u7f8e\u56fdII\/III\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u8fd9\u6807\u5fd7\u7740\u4fe1\u8fea\u5229\u5355\u6297\u5728\u8d28\u91cf\u548c\u5b89\u5168\u6027\u65b9\u9762\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u7684\u521d\u6b65\u8ba4\u53ef\u3002<\/span>
<\/p>\n


<\/span><\/p>\n

\u541b\u5b9ePD-1<\/span><\/strong><\/span><\/p>\n


<\/span><\/strong><\/p>\n

\uff081\uff09\u533b\u79d1\u9662\u80bf\u7624\u533b\u9662I\u671f\u4e34\u5e8a\uff1a\u6709\u6548\u738740%<\/span><\/strong><\/p>\n

\u8fd9\u9879\u541b\u5b9e\u516c\u53f8\u7684PD-1\u6297\u4f53\uff0cI\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7531\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\uff0c\u77f3\u8fdc\u51ef\u6559\u6388\u4e3b\u6301\u3002\u5206\u62103\u4e2a\u5242\u91cf\u7ec4\uff1a 1 mg\/kg\uff0c3 mg\/kg\uff0c10 mg\/kg\uff0c\u5165\u7ec4\u4e8619\u540d\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u3002<\/span><\/p>\n

\u7597\u6548\u65b9\u9762\uff1a15\u4f4d\u60a3\u8005\u53ef\u8bc4\u4ef7\uff0c1\u4f4d\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u5b8c\u5168\u7f13\u89e3\uff0c5\u4f4d\u90e8\u5206\u7f13\u89e3\uff083\u4f4d\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c1\u4f4d\u8f6f\u7ec4\u7ec7\u8089\u7624\uff0c1\u4f4d\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff09\uff0c5 \u4f4d\u75c5\u60c5\u7a33\u5b9a (3\u4f4d\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c 2\u4f4d\u5934\u9888\u90e8\u9cde\u764c)<\/strong><\/span>\u2014\u2014\u603b\u4f53\u7684\u6709\u6548\u7387\u4e3a40%\uff0c\u75be\u75c5\u63a7\u5236\u7387\u4e3a73%<\/strong><\/span>\u3002<\/span><\/p>\n

\u526f\u4f5c\u7528\uff1a\u7edd\u5927\u591a\u6570\u526f\u4f5c\u7528\u4e3a1-2\u7ea7\uff0c\u5305\u62ec\uff1a\u53d1\u70ed\u3001\u8179\u6cfb\u3001\u76ae\u75b9\u3001\u6d41\u611f\u6837\u75c7\u72b6\u3001\u4e4f\u529b\u3001\u9ecf\u819c\u708e\u3001\u809d\u9176\u5347\u9ad8\u4ee5\u53ca\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u7b49\u30021\u4f4d\u60a3\u8005\u51fa\u73b0\u4e863\u7ea7\u7684\u80ba\u708e\uff0c\u4e0e\u836f\u7269\u7684\u76f8\u5173\u6027\u4e0d\u660e\u786e\u3002<\/span><\/p>\n

\uff082\uff09\u5317\u5927\u80bf\u7624\u533b\u9662I\u671f\u4e34\u5e8a\uff1a\u6709\u6548\u738722%<\/span><\/strong><\/span><\/p>\n

\u53e6\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7531\u5317\u4eac\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\uff0c\u90ed\u519b\u6559\u6388\u8d1f\u8d23\uff0c\u5165\u7ec4\u4e8622\u4f4d\u9ed1\u7d20\u7624\u30019\u4f4d\u5c3f\u8def\u4e0a\u76ae\u764c\u30015\u4f4d\u80be\u764c\u60a3\u8005\uff0c\u5171\u8ba136\u540d\u60a3\u8005\u3002<\/span><\/p>\n

\u7597\u6548\u65b9\u9762\uff1a 36\u4f4d\u60a3\u8005\u6cbb\u7597\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a3.93\u4e2a\u6708\uff0c32\u4f4d\u60a3\u8005\u7597\u6548\u53ef\u8bc4\u4ef7\uff1a1\u4f4d\u9ed1\u7d20\u7624\u5b8c\u5168\u7f13\u89e3\uff0c6\u4f4d\u60a3\u8005\u90e8\u5206\u7f13\u89e3\uff083\u4f4d\u9ed1\u7d20\u7624\uff0c2\u4f4d\u80be\u764c\uff0c1\u4f4d\u5c3f\u8def\u4e0a\u76ae\u764c\uff09\uff0c10\u4f4d\u60a3\u8005\u75be\u75c5\u7a33\u5b9a\uff0c15\u60a3\u8005\u75be\u75c5\u8fdb\u5c55<\/strong><\/span>\u2014\u2014\u603b\u4f53\u800c\u8a00\uff0c\u6709\u6548\u7387\u4e3a22%\u3001\u75be\u75c5\u63a7\u5236\u7387\u4e3a53%<\/strong><\/span>\uff0c7\u4f4d\u5ba2\u89c2\u6709\u6548\u7684\u60a3\u8005\u4e2d\u67091\u540d\u60a3\u8005\u4f9d\u7136\u5728\u63a5\u53d7\u6cbb\u7597\u3002\u90ed\u6559\u6388\u56e2\u961f\u53d1\u73b0\uff0c\u90a3\u4e9bPD-L1\u9633\u6027\u7684\u60a3\u8005\uff0c\u6709\u6548\u7387\u66f4\u9ad8\uff0c\u8fbe\u5230\u4e8646%\uff1b\u90a3\u4e9b\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5b58\u5728\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u7684\u60a3\u8005\uff0c\u6709\u6548\u7387\u4e5f\u66f4\u9ad8\uff0c\u8fbe\u5230\u4e8650%\u3002<\/span><\/p>\n

\u526f\u4f5c\u7528\uff1a\u7edd\u5927\u591a\u6570\u60a3\u8005\u4e3a\u8f7b\u5ea6\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u67093\u4f4d\u60a3\u8005\u51fa\u73b0\u4e863-4\u7ea7\u4e0d\u826f\u53cd\u5e94\u2014\u20141\u4f4d\u662f\u86cb\u767d\u5c3f\uff0c2\u4f4d\u662f\u8102\u80aa\u9176\u5347\u9ad8\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u6052\u745ePD-1<\/span><\/strong><\/span><\/p>\n


<\/span><\/strong><\/span><\/p>\n

\uff081\uff09\u56fd\u5185\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1a\u6709\u6548\u738731.0%<\/span><\/strong><\/p>\n

\u7531\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u5f90\u5175\u6cb3\u6559\u6388\u4e3b\u6301\uff0c\u5206\u621060mg 2\u5468\u4e00\u6b21\uff0812\u4f4d\u60a3\u8005\uff09\u3001200 mg 2\u5468\u4e00\u6b21(34 \u4f4d\u60a3\u8005)\u3001400 mg 2\u5468\u4e00\u6b21(12 \u4f4d\u60a3\u8005)\u4e09\u7ec4\uff0c\u672a\u89c2\u5bdf\u5230\u4e25\u91cd\u7684\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u3002<\/span><\/p>\n

\u5165\u7ec4\u7684\u8fd958\u4f4d\u60a3\u8005\uff0c\u5206\u522b\u662f\u5982\u4e0b\u8fd9\u4e9b\u80bf\u7624\uff1a29\u4f4d\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff0c8\u4f4d\u80c3\u764c\uff0c3\u4f4d\u80ba\u764c\uff0c3\u4f4d\u9f3b\u54bd\u764c\uff0c3\u4f4d\u809d\u764c\uff0c 3\u4f4d\u7ed3\u76f4\u80a0\u764c\uff0c1\u4f4d\u8180\u80f1\u764c\uff0c\u53e6\u59168\u4f4d\u60a3\u8005\u75c5\u7406\u7c7b\u578b\u672a\u516c\u5e03\u3002<\/span><\/p>\n

\u7597\u6548\u65b9\u9762\uff1a \u603b\u4f53\u6709\u6548\u7387\u4e3a31.0%\uff0c\u75be\u75c5\u63a7\u5236\u7387\u4e3a46.5%\uff0c\u672a\u89c1\u5b8c\u5168\u7f13\u89e3\u7684\u60a3\u8005<\/strong>\u3002<\/strong><\/span>18\u4f4d\u60a3\u8005\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\uff0c\u5305\u62ec\uff1a 10\u4f4d\u98df\u7ba1\u764c\u30013\u4f4d\u80c3\u764c\u30011\u4f4d\u80ba\u764c\uff0c1\u4f4d\u9f3b\u54bd\u764c\u30011\u4f4d\u809d\u764c\u30011\u4f4d\u7ed3\u76f4\u80a0\u764c\u30011\u4f4d\u8180\u80f1\u764c<\/span><\/strong>\u3002<\/span><\/p>\n

\u526f\u4f5c\u7528\u65b9\u9762\uff1a\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u7624\uff0879.3%\uff0c\u7edd\u5927\u591a\u6570\u90fd\u662f\u8f7b\u5fae\u76841\u7ea7\uff09\uff0c\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\uff0829.3%\uff09\uff0c\u7619\u75d2\uff0819.0%\uff09\uff0c\u8f6c\u6c28\u9176\u5347\u9ad8\uff0813.8%\uff09\uff0c\u80c6\u7ea2\u7d20\u5347\u9ad8\uff0812.1%\uff09\uff0c\u75b2\u4e4f\uff0812.1%\uff09\uff0c\u53d1\u70ed\uff0810.3%\uff09\uff0c\u8179\u6cfb\uff0810.3%\uff09\u3002\u4e00\u51714\u4f4d\u60a3\u8005\u53d1\u751f\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\uff1a1\u4f4d\u6162\u6027\u963b\u585e\u6027\u80ba\u75be\u75c5\u6025\u6027\u53d1\u4f5c\uff0c1\u4f4d\u5fc3\u808c\u808c\u9499\u86cb\u767dI\u5347\u9ad8\uff0c1\u4f4d\u8840\u5c0f\u677f\u51cf\u5c11\uff0c1\u4f4d\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3002<\/span><\/p>\n

\uff082\uff09\u56fd\u5916\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c:\u63a7\u5236\u738743%<\/span><\/strong><\/span><\/p>\n

2015\u5e749\u6708\uff0c\u6052\u745e\u516c\u53f8\u4ee57.95\u4ebf\u7f8e\u5143\u7684\u4ef7\u683c\u5c06\u81ea\u5df1\u7684PD-1\u6297\u4f53\u5728\u6d77\u5916\u5e02\u573a\u7684\u5f00\u53d1\u548c\u9500\u552e\u6743\u76ca\uff0c\u51fa\u552e\u7ed9\u4e86Incyte\u516c\u53f8\u3002Inycte\u516c\u53f8\u5c31\u5728\u6b27\u7f8e\u7b49\u56fd\u5f00\u59cb\u4e86I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bd5\u9a8c\u7684\u7ed3\u679c\u5728\u4e0a\u5468\u7684\u6b27\u6d32\u80bf\u7624\u5b66\u5e74\u4f1a\uff08ESMO\uff09\u4e0a\u6b63\u5f0f\u516c\u5e03\u3002<\/span><\/p>\n

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\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8 2014\u5e747\u6708\u5168\u7403\u9996\u4e2aPD-1\u6291\u5236\u5242OP […]<\/p>\n","protected":false},"author":1,"featured_media":4561,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4560"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=4560"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4560\/revisions"}],"predecessor-version":[{"id":4576,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4560\/revisions\/4576"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/4561"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=4560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=4560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=4560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}