{"id":4577,"date":"2018-07-03T01:00:00","date_gmt":"2018-07-27T06:53:36","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/vismodegib-%e7%bb%b4%e8%8e%ab%e5%be%b7%e5%90%89\/"},"modified":"2018-07-27T14:53:37","modified_gmt":"2018-07-27T06:53:37","slug":"vismodegib-%e7%bb%b4%e8%8e%ab%e5%be%b7%e5%90%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/4577\/","title":{"rendered":"Vismodegib–\u7ef4\u83ab\u5fb7\u5409"},"content":{"rendered":"
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\u70b9\u51fb\u4e0a\u65b9\u7684<\/span> \u884c\u821fDrug \u25b2<\/span> \u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/p>\n


<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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\u836f\u7269\u540d\u79f0<\/span><\/p>\n<\/td>\n

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vismodegib<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u5316\u5b66\u7ed3\u6784<\/span><\/p>\n<\/td>\n

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     <\/p>\n

\"Vismodegib--\u7ef4\u83ab\u5fb7\u5409\"<\/p>\n<\/td>\n<\/tr>\n

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\u5546\u54c1\u540d\u79f0<\/span><\/p>\n<\/td>\n

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Erivedge<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u9002\u5e94\u75c7<\/span><\/p>\n<\/td>\n

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<\/span><\/p>\n

\u80c3\u80bf\u7624\uff1b\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff1b\u80f0\u7ba1\u817a\u764c\uff1b\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff1b\u57fa\u5e95\u7ec6\u80de\u764c\uff1b\u8089\u7624\u7b49\u5404\u79cd\u80bf\u7624\u6027\u75be\u75c5<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u7ed9\u836f\u9014\u5f84<\/span><\/p>\n<\/td>\n

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\u53e3\u670d<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u9776\u70b9<\/span><\/p>\n<\/td>\n

Smoothened receptor antagonist; Hedgehog protein inhibitor<\/span><\/td>\n<\/tr>\n
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\u836f\u7269\u7279\u70b9<\/span><\/p>\n<\/td>\n

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Vismodegib\u662f\u4e00\u79cdHedgehog\uff08Hh\uff09\u4fe1\u53f7\u901a\u8def\u6291\u5236\u5242\uff0c\u901a\u8fc7\u9776\u5411\u6291\u5236Hh\u4fe1\u53f7\u901a\u8def\uff0c\u963b\u65adHh-\u914d\u4f53\u7ec6\u80de\u8868\u9762\u53d7\u4f53PTCH\u548c\/\u6216SMO\u7684\u6d3b\u6027\u4ece\u800c\u5e72\u6270Hh\u901a\u8def\u3002\u8be5\u836f\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u8f6c\u79fb\u57fa\u5e95\u7ec6\u80de\u764c\u6216\u5c40\u90e8\u665a\u671f\u57fa\u5e95\u7ec6\u80de\u764c\u3002Erivedge\u4e3a\u53e3\u670d\u80f6\u56ca\uff0c\u6bcf\u7c92\u542b\u6709150 mg Vismodegib\u3002\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u6b21150 mg\uff0c\u6bcf\u65e51\u6b21\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u539f\u7814\u516c\u53f8<\/span><\/p>\n<\/td>\n

Roche Holding AG; Genentech Inc<\/span><\/td>\n<\/tr>\n
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\u7814\u53d1\u5386\u53f2<\/span><\/p>\n<\/td>\n

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\u5f85\u66f4\u65b0<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u4e0a\u5e02\u65f6\u95f4<\/span><\/p>\n<\/td>\n

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2012<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u56fd\u5185\u4e0a\u5e02\u65f6\u95f4<\/span><\/p>\n<\/td>\n

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2016<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u56fd\u5185\u7533\u62a5\u5382\u5bb6<\/span><\/p>\n<\/td>\n

\u5317\u4eac\u4f9d\u8bfa\u6cf0\u836f\u7269\u5316\u5b66\u6280\u672f\u6709\u9650\u516c\u53f8<\/span>
<\/td>\n<\/tr>\n
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\u539f\u7814\u4e13\u5229<\/span><\/p>\n

\u4fe1\u606f<\/span><\/p>\n<\/td>\n

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\u4e13\u5229\u53f7<\/span><\/p>\n<\/td>\n

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\u5230\u671f\u65e5<\/span><\/p>\n<\/td>\n

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\u4e13\u5229\u540d\u79f0<\/span><\/p>\n<\/td>\n<\/tr>\n

WO-2006028958<\/span><\/td>\n2025<\/span><\/td>\nPyridyl inhibitors of hedgehog signalling.<\/span><\/td>\n<\/tr>\n
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\u5168\u7403\u9500\u552e<\/span><\/p>\n

\u9884\u6d4b<\/span><\/p>\n<\/td>\n

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\"Vismodegib--\u7ef4\u83ab\u5fb7\u5409\"<\/p>\n<\/td>\n<\/tr>\n

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  <\/span><\/span>S <\/span>
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 <\/span> W<\/span><\/span> <\/span><\/span><\/p>\n


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 <\/span> <\/span>O<\/span><\/span> <\/span><\/span><\/p>\n


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  T<\/span><\/span> <\/span><\/span><\/span><\/p>\n


<\/p>\n<\/td>\n

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1. \u9002\u5e94\u75c7\u8f83\u5e7f\uff0c\u5e02\u573a\u4f18\u52bf\u5927<\/span><\/p>\n

2. \u4e00\u5929\u53e3\u670d\u4e00\u6b21\uff0c\u7ed9\u836f\u65b9\u4fbf<\/span><\/p>\n

3. \u4e13\u5229\u4fdd\u62a4\u52302028\u5e74<\/span><\/p>\n<\/td>\n<\/tr>\n

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1. \u9ed1\u76d2\u8b66\u544a<\/span><\/p>\n

2. \u5173\u4e8e\u80ce\u513f\u7578\u5f62\u548c\u9759\u6b62\u7684\u751f\u80b2\u98ce\u9669<\/span><\/p>\n

3. \u4e34\u5e8a\u4e2d\u60a3\u8005\u51fa\u73b0QT\u65f6\u95f4\u5ef6\u957f\u8010\u836f\u6027\u95ee\u9898<\/span><\/p>\n<\/td>\n<\/tr>\n

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1. \u9002\u5e94\u75c7\u5168\u7403\u5e02\u573a\u5bb9\u91cf\u5de8\u5927<\/span><\/p>\n

2. \u57fa\u5e95\u7ec6\u80de\u764c\u662f\u6700\u5e38\u89c1\u7684\u76ae\u80a4\u764c<\/span><\/p>\n<\/td>\n<\/tr>\n

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1. \u57fa\u5e95\u7ec6\u80de\u764c\u5927\u90e8\u5206\u75c5\u4f8b\u53ef\u901a\u8fc7\u624b\u672f\u6216\u5c40\u90e8\u6cbb\u7597\u6765\u6cbb\u7597<\/span><\/p>\n

2. \u6cbb\u7597\u65f6\u95f4\u957f\uff0c\u5b89\u5168\u6027\u98ce\u9669\u8f83\u9ad8<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u539f\u7814\u5de5\u827a\u8def\u7ebf<\/span><\/p>\n<\/td>\n

\u5f85\u66f4\u65b0<\/span><\/td>\n<\/tr>\n
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\u6742\u8d28\u4fe1\u606f<\/span><\/p>\n<\/td>\n

\u5f85\u66f4\u65b0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


<\/p>\n

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Vismodegib<\/span><\/strong><\/span>\u6c64<\/span><\/strong><\/span>\u68ee<\/span><\/strong><\/span><\/span>\u8def\u900f<\/span><\/span><\/strong>Cortellis<\/span><\/strong>\u62a5\u544a\u514d\u8d39\u4e0b\u8f7d<\/span><\/span><\/strong><\/span><\/p>\n

https:\/\/pan.baidu.com\/s\/1m2iXL2P1i5aPrx_VTNvuiA<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n

\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\"Vismodegib--\u7ef4\u83ab\u5fb7\u5409\"<\/p>\n


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\u884c\u821fDrug<\/span><\/p>\n<\/section>\n

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\u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n

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<\/p>\n<\/p>\n<\/section>\n


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\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u884c\u821fDrug <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8 \u836f\u7269\u540d\u79f0 vismodegib \u5316\u5b66\u7ed3\u6784 […]<\/p>\n","protected":false},"author":1,"featured_media":4578,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4577"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=4577"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4577\/revisions"}],"predecessor-version":[{"id":4582,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4577\/revisions\/4582"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/4578"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=4577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=4577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=4577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}