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\u9002\u5e94\u75c7\uff1a\u9aa8\u9ad3\u7ea4\u7ef4\u5316<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2011\u5e74\uff08\u7f8e\u56fd\uff092017\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a5mg 1396\u5143<\/span><\/p>\n

\u82a6\u53ef\u66ff\u5c3c\u662f\u76ee\u524d\u552f\u4e00\u9488\u5bf9\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u53d1\u75c5\u673a\u5236\u7684\u9776\u5411\u6cbb\u7597\u836f\u7269\u3002FDA\u6388\u4e88\u82a6\u53ef\u66ff\u5c3c\u6cbb\u7597\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u7684\u5b64\u513f\u836f\u5730\u4f4d\uff0c\u5e76\u4e8e2011\u5e7411\u670816\u65e5\u5728\u7f8e\u56fd\u4e0a\u5e02\u3002\u8bfa\u534e\u4eceIncyte\u516c\u53f8\u6388\u6743\u83b7\u5f97\u9c81\u7d22\u5229\u66ff\u5c3c\u5728\u7f8e\u56fd\u4ee5\u5916\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\u3002\u82a6\u53ef\u66ff\u5c3c\u5df2\u6210\u4e3a\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u3001\u82f1\u56fd\u3001\u5fb7\u56fd\u3001\u7f8e\u56fd\u56fd\u5bb6\u7efc\u5408\u764c\u75c7\u7f51\u7edc\u6307\u5357\u63a8\u8350\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u6cbb\u7597\u836f\u7269\uff0c\u5e76\u83b7\u5f97\u4e86\u300a\u539f\u53d1\u6027\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u8bca\u65ad\u4e0e\u6cbb\u7597\u4e2d\u56fd\u4e13\u5bb6\u5171\u8bc6\u300b\uff082015\u5e74\u7248\uff09\u7684\u63a8\u8350\uff0c\u53ef\u89c1\u5176\u91cd\u8981\u6027\u3002<\/o:p><\/span><\/p>\n

2017\u5e743\u670810\u65e5\u83b7\u5f97CFDA\u6279\u51c6\u7528\u4e8e\u4e2d\u5371\u6216\u9ad8\u5371\u7684\u539f\u53d1\u6027\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u3001\u771f\u6027\u7ea2\u7ec6\u80de\u589e\u591a\u75c7\u7ee7\u53d1\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u6216\u539f\u53d1\u6027\u8840\u5c0f\u677f\u589e\u591a\u75c7\u7ee7\u53d1\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u7684\u6210\u5e74\u60a3\u8005\uff0c\u6cbb\u7597\u75be\u75c5\u76f8\u5173\u813e\u80bf\u5927\u6216\u75be\u75c5\u76f8\u5173\u75c7\u72b6\u3002\u76ee\u524d\u5728\u56fd\u5185\u5e02\u573a\u8fd8\u8f83\u5c0f\uff0c\u9500\u552e\u5355\u4ef7\u57288000\u5143\u5de6\u53f3\uff0c\u5f88\u53ef\u80fd\u5728\u4eca\u5e74\u7eb3\u5165\u533b\u4fdd\u8c08\u5224\u5e76\u53d6\u5f97\u6210\u529f\u3002<\/o:p><\/span><\/p>\n

\u57f9\u5511\u5e15\u5c3c\u7247(\u7ef4\u5168\u7279)<\/o:p><\/span><\/p>\n

\u9002\u5e94\u75c7\uff1a\u80be\u7ec6\u80de\u764c\u3001\u8fdb\u5c55\u6027\u8f6f\u7ec4\u7ec7\u8089\u7624<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2009\u5e74\uff08\u7f8e\u56fd\uff092017\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a200mg 457\u5143<\/o:p><\/span><\/p>\n

\u57f9\u5511\u5e15\u5c3c\u7247(\u7ef4\u5168\u7279)\uff0c\u662f\u82f1\u56fd\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\u7814\u53d1\u7684\u591a\u9776\u70b9\u836f\uff0c\u73b0\u5f52\u8bfa\u534e\u516c\u53f8\u6240\u6709\uff0c2009\u5e7410\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2017\u5e742\u6708\u5728\u4e2d\u56fd\u5883\u5185\u4e0a\u5e02\uff0c\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u3001\u8fdb\u5c55\u6027\u8f6f\u7ec4\u7ec7\u8089\u7624\u3002\u57f9\u5511\u5e15\u5c3c\u76f8\u8f83\u4e8e\u8212\u5c3c\u66ff\u5c3c\uff0c\u4e0d\u826f\u53cd\u5e94\u66f4\u8f7b\u3002<\/span><\/p>\n

4\uff0c\u6b66\u7530\u5236\u836f<\/span><\/strong><\/p>\n

\u67b8\u6a7c\u9178\u4f0a\u6c99\u4f50\u7c73\u80f6\u56ca(\u6069\u83b1\u745e)<\/o:p><\/span><\/p>\n

\u9002\u5e94\u75c7\uff1a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2015\u5e74\uff08\u7f8e\u56fd\uff092018\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a4mg 22473\u5143<\/o:p><\/span><\/p>\n

\u67b8\u6a7c\u9178\u4f0a\u6c99\u4f50\u7c73\u80f6\u56ca(\u6069\u83b1\u745e)\uff0c\u7531\u65e5\u672c\u6b66\u7530\u5236\u836f\u7814\u53d1\uff0c2015\u5e7411\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2018\u5e744\u6708\u5728\u4e2d\u56fd\u5883\u5185\u4e0a\u5e02\u3002\u5b83\u4e3a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u5f00\u542f\u4e86\u9996\u4e2a\u5168\u53e3\u670d\u6cbb\u7597\u65b9\u6848\u3002<\/o:p><\/span><\/p>\n

5\uff0c\u7f8e\u56fd\u5f3a\u751f\u516c\u53f8<\/span><\/strong><\/p>\n

\u4f0a\u5e03\u66ff\u5c3c\u80f6\u56ca(\u4ebf\u73c2)<\/o:p><\/span><\/p>\n

\u9002\u5e94\u75c7\uff1a\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u3001\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3001\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2013\u5e74\uff08\u7f8e\u56fd\uff092017\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a140mg*90\u7c9284416\u5143\uff1b140mg*120\u7c92111003\u5143<\/o:p><\/span><\/p>\n

\u4f0a\u5e03\u66ff\u5c3c\u80f6\u56ca(\u4ebf\u73c2)\uff0c\u7531\u7f8e\u56fd\u5f3a\u751f\u7b49\u516c\u53f8\u8054\u5408\u7814\u53d1\uff0c2013\u5e7411\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2017\u5e748\u6708\u5728\u4e2d\u56fd\u5883\u5185\u4e0a\u5e02\uff0c\u9002\u7528\u4e8e\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u3001\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3001\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\u7b49\u7f55\u89c1\u75c5\u3002\u7814\u7a76\u8868\u660e\uff0c\u60a3\u8005\u8d8a\u65e9\u4f7f\u7528\u4f0a\u5e03\u66ff\u5c3c\uff0c\u751f\u5b58\u83b7\u76ca\u8d8a\u5927\u3002<\/o:p><\/span><\/p>\n

\u4f0a\u5e03\u66ff\u5c3c\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7684BTK\u6291\u5236\u5242\uff0c\u7531\u5f3a\u751f\u548cPharmacyclics\u5408\u4f5c\u5f00\u53d1\uff0c\u6700\u65e9\u662f\u4e8e2013\u5e7411\u670813\u65e5\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u4e0a\u5e02\u4e4b\u540e\u9500\u552e\u989d\u7a81\u98de\u731b\u8fdb\u3002\u53bb\u5e74\u5168\u7403\u9500\u552e\u989d\u8fbe44.66\u4ebf\u7f8e\u5143\u3002<\/o:p><\/span><\/p>\n

\u5728\u56fd\u5185\uff0c\u5f3a\u751f\u6700\u65e9\u4e8e2013\u5e749\u67086\u65e5\u5728\u4e2d\u56fd\u63d0\u4ea4\u4e86\u4f0a\u5e03\u66ff\u5c3c\u7684\u6ce8\u518c\u7533\u8bf7\uff0c\u4e8e2017\u5e748\u670828\u65e5\u83b7\u5f97CFDA\u9881\u53d1\u7684\u751f\u4ea7\u6279\u4ef6\uff0c\u672a\u6765\u5e02\u573a\u63d0\u5347\u7a7a\u95f4\u8f83\u5927\u3002<\/o:p><\/span><\/p>\n

\u76ee\u524d\uff0c\u5e02\u573a\u4e0a\u4f0a\u5e03\u66ff\u5c3c\u7684\u552e\u4ef7\u63a5\u8fd15\u4e07\u5143\/\u74f6\u3002\u867d\u7136\u6709\u8d60\u836f\u653f\u7b56\uff08\u4e705\u8d603\uff09\uff0c\u4f46\u7b97\u4e0b\u6765\u4e00\u76d2\u4e5f\u89813\u4e07\u5143\uff0c\u800c\u4e14\u9700\u8981\u957f\u671f\u670d\u7528\u4e0d\u80fd\u505c\u836f\uff0c\u5bf9\u4e2d\u56fd\u666e\u901a\u60a3\u8005\u6765\u8bf4\u538b\u529b\u975e\u5e38\u5927\u3002\u56e0\u6b64\u7eb3\u5165\u533b\u4fdd\u8c08\u5224\u52bf\u5728\u5fc5\u884c\u3002\u4f46\u4f0a\u5e03\u66ff\u5c3c\u4e13\u5229\u5230\u671f\u65f6\u95f4\u57282026\u5e74\uff0c\u4e14\u8c08\u5224\u4ef7\u683c\u538b\u529b\u5de8\u5927\u3002<\/o:p><\/span><\/p>\n

6\uff0c\u767e\u6d4e\u795e\u5dde<\/span><\/strong><\/p>\n

\u6ce8\u5c04\u7528\u963f\u624e\u80de\u82f7(\u7ef4\u8fbe\u838e)<\/o:p><\/span><\/p>\n

\u9002\u5e94\u75c7\uff1a\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\u3001\u6162\u6027\u7c92-\u5355\u6838\u7ec6\u80de\u767d\u8840\u75c5<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2004\u5e74\uff08\u7f8e\u56fd\uff092018\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a100mg 2625\u5143<\/o:p><\/span><\/p>\n

\u6ce8\u5c04\u7528\u963f\u624e\u80de\u82f7(\u7ef4\u8fbe\u838e)\uff0c\u7531\u7f8e\u56fd\u65b0\u57fa\u516c\u53f8\u6536\u8d2d\u7684\u4e00\u5bb6\u836f\u4f01\u5f00\u53d1\uff0c\u4e8e2004\u5e745\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2017\u5e74\uff0c\u767e\u6d4e\u795e\u5dde\u83b7\u5f97\u65b0\u57fa\u516c\u53f8\u6388\u4e88\u7684\u72ec\u5bb6\u7ecf\u9500\uff0c\u53ef\u5728\u4e2d\u56fd\u72ec\u5bb6\u9500\u552e\u7ef4\u8fbe\u838e\uff0c2018\u5e742\u6708\u5728\u4e2d\u56fd\u5883\u5185\u4e0a\u5e02\u3002\u8be5\u836f\u7528\u4e8e\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\u3001\u6162\u6027\u7c92-\u5355\u6838\u7ec6\u80de\u767d\u8840\u75c5\u7b49\u75be\u75c5\u7684\u6cbb\u7597\uff0c\u662f\u552f\u4e00\u88ab\u8bc1\u5b9e\u53ef\u5ef6\u957f\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\u60a3\u8005\u751f\u5b58\u671f\u7684\u53bb\u7532\u57fa\u5316\u4ea7\u54c1\u3002<\/o:p><\/span><\/p>\n

7\uff0c\u82f1\u56fd\u963f\u65af\u5229\u5eb7\u516c\u53f8<\/span><\/strong><\/p>\n

\u7532\u78fa\u9178\u5965\u5e0c\u66ff\u5c3c\u7247(\u6cf0\u745e\u6c99)<\/o:p><\/span><\/p>\n

\u9002\u5e94\u75c7\uff1a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2015\u5e74\uff08\u7f8e\u56fd\uff092017\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a80mg 1760\u5143<\/o:p><\/span><\/p>\n

\u7532\u78fa\u9178\u5965\u5e0c\u66ff\u5c3c\u7247(\u6cf0\u745e\u6c99)\uff0c\u7531\u963f\u65af\u5229\u5eb7\u5f00\u53d1\uff0c\u662f\u7b2c\u4e09\u4ee3\u9776\u5411\u836f\u7269\uff0c\u4e3b\u8981\u9488\u5bf9\u7b2c\u4e00\u4ee3\u9776\u5411\u836f\u7269\u7684T790M\u8010\u836f\u7a81\u53d8\u30022015\u5e7411\u6708\uff0c\u5965\u5e0c\u66ff\u5c3c\u83b7FDA\u6279\u51c6\u5728\u7f8e\u56fd\u9996\u5148\u4e0a\u5e02\uff0c\u662f\u7f8e\u56fdFDA\u6709\u53f2\u4ee5\u6765\u4e0a\u5e02\u6700\u5feb\u7684\u6297\u764c\u836f\uff0c\u4ece\u4e34\u5e8a\u8bd5\u9a8c\u5230\u4e0a\u5e02\u8bb8\u53ef\u4ec5\u5386\u65f6\u4e24\u5e74\u534a\u3002\u76ee\u524d\u5168\u7403\u9500\u552e\u989d\u63a5\u8fd110\u4ebf\u7f8e\u5143\u3002<\/o:p><\/span><\/p>\n

\u5728\u4e2d\u56fd\uff0c\u5965\u5e0c\u66ff\u5c3c\u8fdb\u5165\u4e86CFDA\u5feb\u901f\u5ba1\u6279\u901a\u9053\u540e\uff0c\u4ece\u53d7\u7406\uff082016\u5e749\u6708\uff09\u5230\u4e0a\u5e02\u7533\u8bf7\u6279\u51c6\uff082017\u5e743\u6708\uff09\u4ec5\u7528\u4e867\u4e2a\u6708\uff0c\u6210\u4e3a\u6211\u56fd\u65b0\u836f\u5ba1\u6279\u6539\u9769\u540e\u4e0a\u5e02\u5ba1\u6279\u65f6\u95f4\u6700\u77ed\u7684\u836f\u7269\uff0c\u4e13\u95e8\u9488\u5bf9\u7531EGFR\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002\u6b27\u7f8e\u80ba\u764c\u60a3\u8005\u4e2dEGFR\u7a81\u53d8\u4e0d\u523010%\uff0c\u800c\u4e2d\u56fd\u4e2d\u5374\u6709\u8fd130%\uff0c\u80ba\u817a\u764c\u4e2d\u66f4\u662f\u9ad8\u8fbe50%\u4ee5\u4e0a\uff01\u53ef\u89c1\u8be5\u836f\u5728\u6211\u56fd\u5e02\u573a\u7684\u91cd\u8981\u610f\u4e49\u548c\u5de8\u5927\u7684\u5e02\u573a\u7a7a\u95f4\u3002<\/o:p><\/span><\/p>\n

\u4f46\u5965\u5e0c\u66ff\u5c3c\u6bcf\u76d2\u5e73\u5747\u8d85\u8fc75\u4e07\u4eba\u6c11\u5e01\u7684\u552e\u4ef7\uff0c\u5bf9\u666e\u901a\u60a3\u8005\u6765\u8bf4\u538b\u529b\u5de8\u5927\u3002\u540c\u65f6\uff0c\u8be5\u836f\u4e13\u5229\u5230\u671f\u65f6\u95f4\u57282032\u5e74\uff0c\u6b64\u6b21\u533b\u4fdd\u51c6\u5165\u8c08\u5224\u538b\u529b\u6781\u5927\u3002\u5982\u8981\u8c08\u5224\u6210\u529f\uff0c\u5fc5\u5b9a\u4f1a\u5bf9\u5176\u4ef7\u683c\u4e0d\u65ad\u65bd\u538b\uff0c\u4ece\u800c\u8fbe\u5230\u533b\u4fdd\u57fa\u91d1\u627f\u53d7\u8303\u56f4\uff0c\u63d0\u9ad8\u4eba\u4eec\u7684\u7528\u836f\u53ef\u8d1f\u62c5\u6027\u3002<\/o:p><\/span><\/p>\n

8\uff0c\u7f8e\u56fd\u8f89\u745e\u516c\u53f8<\/span><\/strong><\/p>\n

\u514b\u5511\u66ff\u5c3c\u80f6\u56ca(\u8d5b\u745e\u514b)<\/o:p><\/span><\/p>\n

\u9002\u5e94\u75c7\uff1a\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\u9633\u6027\u665a\u671f\u3001\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2011\u5e74\uff08\u7f8e\u56fd\uff092013\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a250mg 890\u5143\uff1b200mg 749\u5143<\/o:p><\/span><\/p>\n

\u514b\u5511\u66ff\u5c3c\u80f6\u56ca(\u8d5b\u745e\u514b)\uff0c\u662f\u7f8e\u56fd\u8f89\u745e\u516c\u53f8\u7814\u53d1\u7684\u53e3\u670d\u591a\u9776\u70b9\u836f\uff0c2011\u5e748\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2013\u5e741\u6708\u5728\u4e2d\u56fd\u5883\u5185\u4e0a\u5e02\u3002\u4e3b\u8981\u6cbb\u7597\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\u9633\u6027\u665a\u671f\u3001\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002\u4e0e\u6807\u51c6\u542b\u94c2\u5316\u7597\u76f8\u6bd4\uff0c\u514b\u5511\u66ff\u5c3c\u53ef\u660e\u663e\u5ef6\u957f\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3002<\/o:p><\/span><\/p>\n

\u963f\u6614\u66ff\u5c3c\u7247(\u82f1\u7acb\u8fbe)<\/o:p><\/span><\/p>\n

\u9002\u5e94\u75c7\uff1a\u80be\u7ec6\u80de\u764c<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2012\u5e74\uff08\u7f8e\u56fd\uff092015\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a5mg 704\u5143\uff1b1mg 200\u5143<\/o:p><\/span><\/p>\n

\u963f\u6614\u66ff\u5c3c\u7247(\u82f1\u7acb\u8fbe)\uff0c\u7531\u7f8e\u56fd\u8f89\u745e\u516c\u53f8\u7814\u5236\uff0c\u4e8e2012\u5e741\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2015\u5e744\u6708\u5728\u4e2d\u56fd\u5883\u5185\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u5176\u4ed6\u836f\u6cbb\u7597\u65e0\u6548\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u3002\u7814\u7a76\u663e\u793a\uff0c\u963f\u6614\u66ff\u5c3c\u53ef\u663e\u8457\u5ef6\u957f\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\u3002<\/o:p><\/span><\/p>\n

\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c\u80f6\u56ca(\u7d22\u5766)<\/o:p><\/span><\/p>\n

\u9002\u5e94\u75c7\uff1a\u80be\u7ec6\u80de\u764c<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2006\u5e74\uff08\u7f8e\u56fd\uff092008\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a12.5mg 454\u5143<\/o:p><\/span><\/p>\n

\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c\u80f6\u56ca(\u7d22\u5766)\uff0c\u662f\u7f8e\u56fd\u8f89\u745e\u7814\u53d1\u7684\u53e3\u670d\u591a\u9776\u70b9\u836f\uff0c\u4e8e2006\u5e741\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2008\u5e74\u5728\u4e2d\u56fd\u5883\u5185\u4e0a\u5e02\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5176\u5728\u4e00\u7ebf\u548c\u4e8c\u7ebf\u80be\u7ec6\u80de\u764c\u6cbb\u7597\u4e2d\uff0c\u6709\u4f18\u4e8e\u4f20\u7edf\u6cbb\u7597\u7684\u7597\u6548\u3002\u5b83\u5bf9\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u7b49\u4e5f\u6709\u7597\u6548\u3002<\/o:p><\/span><\/p>\n

\u8212\u5c3c\u66ff\u5c3c\u662f\u53e3\u670d\u591a\u9776\u70b9TKI\uff0c\u5177\u6709\u53cc\u91cd\u6297\u80bf\u7624\u4f5c\u7528\u3002FDA\u4e8e2006\u5e74\u6279\u51c6\u5176\u7528\u4e8emRCC\u7684\u6cbb\u7597\uff0c2007\u5e74\u8c41\u514d\u4e34\u5e8a\u8bd5\u9a8c\u5728\u56fd\u5185\u4e0a\u5e02\u30022017\u5e74\u5168\u7403\u5e02\u573a\u9500\u552e\u989d\u8d85\u8fc710\u4ebf\u7f8e\u5143\uff0c\u5728\u56fd\u5185\u5e02\u573a\u4e5f\u8d85\u8fc72\u4ebf\u5143\u3002\u4e13\u5229\u5230\u671f\u65f6\u95f4\u57282021\u5e74\u524d\u540e\uff0c\u56fd\u5185\u6709\u9f50\u9c81\u5236\u836f\u7b49\u4f01\u4e1a\u7533\u62a5\u3002<\/o:p><\/span><\/p>\n

\u8212\u5c3c\u66ff\u5c3c\u5168\u56fd\u5e73\u5747\u4ef7\u683c\u572813100\u5143\/\u76d2\u5de6\u53f3\uff0c\u73b0\u5df2\u8fdb\u5165\u591a\u4e2a\u5730\u65b9\u7684\u7701\u7ea7\u533b\u4fdd\u3002\u5e76\u4e14\u6839\u636e\u60a3\u8005\u4e0d\u540c\u7684\u75be\u75c5\u79cd\u7c7b\u6709\u76f8\u5173\u6148\u5584\u8d60\u836f\u653f\u7b56\u3002\u9884\u8ba1\u4eca\u5e74\u6709\u5f88\u5927\u53ef\u80fd\u4f1a\u4e00\u4e3e\u8fdb\u5165\u56fd\u5bb6\u533b\u4fdd\u8c08\u5224\u76ee\u5f55\u3002<\/o:p><\/span><\/p>\n

9\uff0c\u5fb7\u56fd\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8<\/span><\/strong><\/p>\n

\u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c\u7247(\u5409\u6cf0\u745e)<\/o:p><\/span><\/p>\n

\u9002\u5e94\u75c7\uff1a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2013\u5e74\uff08\u7f8e\u56fd\uff092017\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a40mg 328\u5143\uff1b30mg 264\u5143<\/o:p><\/span><\/p>\n

\u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c\u7247(\u5409\u6cf0\u745e)\uff0c\u662f\u5fb7\u56fd\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u7814\u53d1\u7684\u9776\u5411\u836f\uff0c2013\u5e747\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2017\u5e742\u6708\u5728\u4e2d\u56fd\u5883\u5185\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597EGFR\u7a81\u53d8\u9633\u6027\u7684\u80ba\u764c\u60a3\u8005\u3001\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u7ec4\u7ec7\u5b66\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002<\/o:p><\/span><\/p>\n

10\uff0c\u5fb7\u56fd\u62dc\u8033\u516c\u53f8<\/span><\/strong><\/p>\n

\u745e\u6208\u975e\u5c3c\u7247(\u62dc\u4e07\u6208)<\/o:p><\/span><\/p>\n

\u9002\u5e94\u75c7\uff1a\u809d\u764c<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2012\u5e74\uff08\u7f8e\u56fd\uff092017\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a40mg 360\u5143<\/o:p><\/span><\/p>\n

\u745e\u6208\u975e\u5c3c\u7247(\u62dc\u4e07\u6208)\u4e3b\u6cbb\u809d\u7ec6\u80de\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u3002\u5b83\u662f\u5fb7\u56fd\u62dc\u8033\u516c\u53f8\u7814\u53d1\u7684\u53e3\u670d\u591a\u9776\u70b9\u836f\uff0c2012\u5e749\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2017\u5e7412\u6708\u5728\u4e2d\u56fd\u5883\u5185\u4e0a\u5e02\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u809d\u764c\u60a3\u8005\uff0c\u53ef\u5e26\u6765\u66f4\u957f\u7684\u751f\u5b58\u83b7\u76ca\u3002\u745e\u6208\u975e\u5c3c\u662f\u8fd1\u5341\u5e74\u6765\u9996\u4e2a\u5728\u4e2d\u56fd\u5883\u5185\u83b7\u6279\u4e0a\u5e02\u7684\u809d\u764c\u6cbb\u7597\u65b0\u836f\u3002\u76ee\u524d\u56fd\u5185\u83b7\u6279\u4e0a\u5e02\u7684\u809d\u764c\u9776\u5411\u836f\u67093\u79cd\uff0c\u745e\u6208\u975e\u5c3c\u662f\u7ee7\u7d22\u62c9\u975e\u5c3c\u4e4b\u540e\u7684\u7b2c\u4e8c\u79cd\uff0c\u7b2c\u4e09\u79cd\u4e50\u4f10\u66ff\u5c3c\u521a\u83b7\u6279\u8fd8\u672a\u5728\u4e34\u5e8a\u666e\u53ca\u3002<\/o:p><\/span><\/p>\n

11\uff0c\u5fb7\u56fd\u9ed8\u514b\u516c\u53f8<\/span><\/strong><\/p>\n

\u897f\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2(\u7231\u5fc5\u59a5)<\/o:p><\/span><\/p>\n

\u9002\u5e94\u75c7\uff1a\u7ed3\u76f4\u80a0\u764c<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2003\u5e74\uff08\u745e\u58eb\uff092006\u5e74\uff08\u4e2d\u56fd\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a100mg\/20ml 4400\u5143<\/o:p><\/span><\/p>\n

\u897f\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2(\u7231\u5fc5\u59a5)\u4e3b\u6cbb\u7ed3\u76f4\u80a0\u764c\u3002\u7531\u7f8e\u56fd\u82f1\u514b\u9686\u516c\u53f8\u4e0e\u7f8e\u56fd\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\u7814\u53d1\uff0c\u5fb7\u56fd\u9ed8\u514b\u516c\u53f8\u8425\u9500\u30022003\u5e74\u5728\u745e\u58eb\u4e0a\u5e02\uff0c2006\u5e74\u5728\u4e2d\u56fd\u5883\u5185\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7b49\u3002\u897f\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2\u5728\u5f53\u524d\u7ed3\u76f4\u80a0\u764c\u6cbb\u7597\u4e2d\u975e\u5e38\u91cd\u8981\uff0c\u4f46\u7528\u836f\u4e00\u4e2a\u6708\u8981\u82b18\u4e07\u5143\u5de6\u53f3\uff0c\u4fc3\u5176\u8fdb\u5165\u533b\u4fdd\u5c24\u4e3a\u8feb\u5207\u3002<\/o:p><\/span><\/p>\n

12\uff0c\u7ef4\u83ab\u975e\u5c3c\u7247(\u4f50\u535a\u4f0f)<\/span><\/strong><\/p>\n

\u9002\u5e94\u75c7\uff1a\u9ed1\u8272\u7d20\u7624<\/o:p><\/span><\/p>\n

\u4e0a\u5e02\u65f6\u95f4\uff1a2011\u5e74\uff08\u7f8e\u56fd\uff092017\u5e74\uff08\u4e2d\u56fd\u5883\u5185\uff09<\/o:p><\/span><\/p>\n

\u4e2d\u6807\u4ef7\u683c\uff1a240mg 210\u5143<\/o:p><\/span><\/p>\n

\u7ef4\u83ab\u975e\u5c3c\u7247(\u4f50\u535a\u4f0f)\u4e3b\u6cbb\u9ed1\u8272\u7d20\u7624\u3002\u7531\u745e\u58eb\u7f57\u6c0f\u5236\u836f\u5f00\u53d1\uff0c2011\u5e748\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2017\u5e743\u6708\u5f97\u5230\u6211\u56fd\u52a0\u901f\u6279\u51c6\uff0c\u63d0\u524d\u4e24\u5e74\u4e0a\u5e02\uff0c\u662f\u4e2d\u56fd\u5883\u5185\u9996\u4e2a\u9ed1\u8272\u7d20\u7624\u9776\u5411\u836f\u3002\u8fc7\u53bb\u6709BRAF\u57fa\u56e0\u7a81\u53d8\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u80bf\u7624\u8f6c\u79fb\u540e\uff0c\u57fa\u672c\u6ca1\u6709\u6709\u6548\u6cbb\u7597\u836f\u7269\uff0c\u7ef4\u83ab\u975e\u5c3c\u5728\u665a\u671f\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\u53f2\u4e0a\u662f\u4e2a\u91cc\u7a0b\u7891\u3002\u5176\u7528\u836f\u7597\u7a0b\u4e3a\u4e00\u5468\u4e00\u76d2\uff0c\u6bcf\u76d2\u6807\u4ef710360\u5143\uff0c\u5168\u5e74\u81ea\u8d39\u8d39\u7528\u572850\u4e07\u5143\uff0c\u4f46\u662f\u7531\u4e8e\u7ef4\u7f57\u975e\u5c3c\u662f\u76ee\u524d\u56fd\u5185\u552f\u4e00\u4e00\u6b3e\u9ed1\u8272\u7d20\u7624\u9776\u5411\u836f\u7269\uff0c\u5e02\u573a\u6f5c\u529b\u8fd8\u6709\u671b\u7ee7\u7eed\u63d0\u5347\u3002<\/o:p><\/span><\/p>\n

\u4ece\u4eca\u5e745\u67081\u65e5\u8d77,\u6211\u56fd\u6267\u884c\u8fdb\u53e3\u6297\u764c\u836f\u96f6\u5173\u7a0e,\u540c\u65f6\u5bf9\u8fdb\u53e3\u6297\u764c\u836f\u51cf\u63093%\u5f81\u6536\u8fdb\u53e3\u73af\u8282\u589e\u503c\u7a0e,\u4f46\u4ef7\u683c\u8fd8\u662f\u6ca1\u6709\u663e\u8457\u4e0b\u964d\u3002\u76f8\u6bd4\u5173\u7a0e\u7684\u5f71\u54cd,\u836f\u4ef7\u8c08\u5224\u624d\u662f\u5f71\u54cd\u6297\u764c\u836f\u4ef7\u683c\u6700\u91cd\u8981\u7684\u56e0\u7d20\u3002\u5982\u679c18\u79cd\u836f\u54c1\u6700\u7ec8\u5168\u90e8\u8fdb\u5165\u533b\u4fdd\uff0c\u7ed9\u666e\u901a\u60a3\u8005\u5e26\u6765\u7684\u597d\u5904\u662f\u663e\u800c\u6613\u89c1\u7684\u3002 <\/span><\/p>\n

\u6765\u6e90<\/strong>\uff1aE\u836f\u8138\u8c31\u7f51<\/strong><\/span><\/p>\n

\"\u65b0\u4e00\u8f6e\u836f\u4ef7\u8c08\u5224\u4e3b\u8981\u5de5\u4f5c\u5b8c\u6210\uff0c\u8bfa\u534e\u6210\u5927\u8d62\u5bb6\uff0118\u54c1\u79cd\u7b80\u6790\"<\/p>\n

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