{"id":46009,"date":"2018-09-20T01:00:00","date_gmt":"2018-09-26T01:24:14","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e7%94%9f%e5%91%bd%e7%a7%91%e5%ad%a6%e9%a2%86%e5%9f%9f%e5%80%bc%e5%be%97%e5%85%b3%e6%b3%a8%e7%9a%84%e6%8e%88%e6%9d%83%e4%ba%a4%e6%98%93%e8%ae%b8%e5%8f%af2018%e5%b9%b4%e7%ac%ac%e4%ba%8c%e5%ad%a3\/"},"modified":"2018-09-26T09:24:19","modified_gmt":"2018-09-26T01:24:19","slug":"%e7%94%9f%e5%91%bd%e7%a7%91%e5%ad%a6%e9%a2%86%e5%9f%9f%e5%80%bc%e5%be%97%e5%85%b3%e6%b3%a8%e7%9a%84%e6%8e%88%e6%9d%83%e4%ba%a4%e6%98%93%e8%ae%b8%e5%8f%af2018%e5%b9%b4%e7%ac%ac%e4%ba%8c%e5%ad%a3","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/46009\/","title":{"rendered":"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><span style=\"font-size: 14px;\">\u539f\u6587\u4f5c\u8005\uff1a<span style=\"line-height: 115%;font-family: Calibri, sans-serif;\">PaulD&#8217;Souza<\/span><\/span><\/p>\n<hr  \/>\n<p><span style=\"font-size: 14px;\">\u4e2d\u6587\u7ffb\u8bd1\uff1a \u50a8\u65fb\u534e<\/span><\/p>\n<section style=\"box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u7b80\u4ecb<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\uff0cCortellis\u7ade\u4e89\u60c5\u62a5\u5171\u8bb0\u5f55\u4e86985\u7b14\u65b0\u7684\u6388\u6743\u8bb8\u53ef\u4ea4\u6613\uff08\u4e0d\u5305\u62ec\u5e76\u8d2d\u4ea4\u6613\uff09\uff0c\u62ab\u9732\u7684\u4ea4\u6613\u603b\u91d1\u989d\u4e3a195\u4ebf\u7f8e\u5143\u30022018\u5e74\u7b2c\u4e00\u5b63\u5ea6\u7684\u4ea4\u6613\u91cf\u548c\u4ea4\u6613\u603b\u989d\u5206\u522b\u662f964\u7b14\u548c356\u4ebf\u7f8e\u5143\uff0c2017\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5206\u522b\u4e3a1104\u7b14\u548c136\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u4e0e\u6b64\u6bd4\u8f83\uff0c\u8bf4\u660e\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u6388\u6743\u8bb8\u53ef\u4ea4\u6613\u6b63\u5728\u6301\u7eed\u5f00\u5c55\u4e2d\uff08\u56fe1\uff09\u3002\u7b2c\u4e8c\u5b63\u5ea6\u7684\u603b\u4ea4\u6613\u989d\u867d\u7136\u8fd8\u6ca1\u6709\u8fbe\u52302014\u5e74\u7684\u5cf0\u503c\uff08\u5f53\u65f6\u8bfa\u534e\u4ee5160\u4ebf\u7f8e\u5143\u8d2d\u4e70\u4e86\u845b\u5170\u7d20\u53f2\u514b\u7684\u80bf\u7624\u836f\u7269\u7ec4\u5408\uff09\uff0c\u4f46\u662f\u4e5f\u5df2\u7ecf\u8d85\u8fc7\u4e86\u4e0a\u4e00\u4e2a\u5b63\u5ea6\uff0c\u8fd9\u4e3b\u8981\u5f52\u56e0\u4e8eAllogene 28\u4ebf\u7f8e\u5143\u83b7\u5f97\u4e86Cellectis\u7684\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08CAR-T\uff09\u514d\u75ab\u6cbb\u7597\u4ea7\u54c1\u7684\u6388\u6743\u8bb8\u53ef\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537925056.jpg\" alt=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\" title=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;font-size: 12px;box-sizing: border-box;\">\u56fe1\uff1a2010-2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u7684\u4ea4\u6613\u6d3b\u52a8\uff08\u6765\u6e90\uff1a\u79d1\u777f\u552f\u5b89Cortellis\u7ade\u4e89\u60c5\u62a5\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><span style=\"color: rgb(122, 79, 214);\">\u4ea4\u6613\u989d5\u4ebf\u7f8e\u5143\u53ca\u4ee5\u4e0a\u7684\u9ad8\u989d\u4ea4\u6613<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u6211\u4eec\u8ffd\u8e2a\u4e862018\u5e74\u7b2c\u4e8c\u5b63\u5ea640\u7b14\u4ea4\u6613\u4ef7\u8d85\u8fc71\u4ebf\u7f8e\u5143\u7684\u65b0\u6388\u6743\u8bb8\u53ef\u4ea4\u6613\u3002\u4ee5\u4e0b\u662f\u4ea4\u6613\u989d\u8d85\u8fc75\u4ebf\u7f8e\u5143\u7684\u90e8\u5206\u4ea4\u6613\uff08\u89c1\u56fe2\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\"><br  \/><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"text-align: justify;\"><span style=\"font-size: 14px;color: rgb(122, 79, 214);\">Allogene\u83b7\u5f97\u4e86\u8f89\u745e\u7684\u6297\u764cCAR-T\u4ea7\u54c1\u4ee5\u53ca<\/span><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u4ef7\u503c28\u4ebf\u7f8e\u5143\u7684\u4e0eCellectis\u7684\u5408\u4f5c\u534f\u8bae<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">Allogene\u4eceCellectis\u4e4b\u524d\u7684\u5408\u4f5c\u65b9\u8f89\u745e\uff08Pfizer\uff09\u624b\u91cc\u83b7\u5f97\u4e86Cellectis\u7684CAR-T\u4ea7\u54c1\u7ebf\uff0c\u63a5\u4e0b\u6765\u8be5\u516c\u53f8\u5c06\u4e0eCellectis\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u8fdb\u4e34\u5e8a\u524d\u5f02\u57fa\u56e0CAR-T\u514d\u75ab\u7597\u6cd5\u4e0e\u5316\u7597\u8054\u5408\u7684\u7814\u7a76\uff0c\u8fd9\u4e00\u5408\u4f5c\u4ef7\u503c28\u4ebf\u7f8e\u5143\u3002\u5408\u4f5c\u5171\u6d89\u53ca15\u4e2a\u9776\u70b9\uff0c\u6bcf\u4e2a\u9776\u70b9Cellectis\u5c06\u53ef\u80fd\u83b7\u5f971.85\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\u4ee5\u53ca\u540e\u7eed\u7684\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537925056.jpg\" alt=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\" title=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"text-align: left;white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;font-size: 12px;box-sizing: border-box;\">\u56fe2\uff1a\u6839\u636e\u62ab\u9732\u7684\u4ea4\u6613\u989d\u7b5b\u9009\u76842018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u7684\u90e8\u5206\u5927\u989d\u4ea4\u6613\uff08\u6765\u6e90\uff1a\u79d1\u777f\u552f\u5b89Cortellis\u7ade\u4e89\u60c5\u62a5\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u52c3\u6797\u683c\u6bb7\u683c\u7ff014\u4ebf\u7f8e\u5143\u83b7\u5f97OSE\u7684<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u6297SIRP\u764c\u75c7\u5019\u9009\u836f\u7269<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\uff08Boehringer Ingelheim\uff0cBI\uff09\u8d2d\u4e70OSE Immunotherapeutics\u7684OSE-172\uff0c\u79ef\u6781\u62d3\u5c55\u80bf\u7624\u514d\u75ab\u4e1a\u52a1\u3002OSE-172\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u963b\u65ad\u4fe1\u53f7\u8c03\u8282\u86cb\u767d\uff08SIRP\uff09\u03b1\u548cCD47\u4e4b\u95f4\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u76f8\u4e92\u4f5c\u7528\uff0c\u76ee\u524d\u8fd8\u5728\u4e34\u5e8a\u524d\u9636\u6bb5\u3002BI\u4e3a\u6b64\u652f\u4ed81800\u4e07\u7f8e\u5143\u524d\u671f\u6b3e\uff0c\u8fdb\u5165I\u671f\u4e34\u5e8a\u540e\u5c06\u652f\u4ed81800\u4e07\u7f8e\u5143\uff0c\u8fdb\u4e00\u6b65\u5f00\u53d1\u3001\u5546\u4e1a\u5316\u548c\u9500\u552e\u91cc\u7a0b\u91d1\u8d85\u8fc713.5\u4ebf\u7f8e\u5143\uff0c\u6b64\u5916\u8fd8\u5305\u62ec\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);letter-spacing: 0px;box-sizing: border-box;font-size: 14px;\">\u767e\u5065\u548cIonis\u5c31\u53cd\u4e49\u795e\u7ecf\u7cfb\u7edf\u836f\u7269\u8fbe\u6210<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);letter-spacing: 0px;box-sizing: border-box;font-size: 14px;\">12.7\u4ebf\u7f8e\u5143\u7684\u4ea4\u6613<br style=\"box-sizing: border-box;\"  \/><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u57fa\u4e8e\u4e4b\u524d\u7684\u5408\u4f5c\uff0c\u767e\u5065\uff08Biogen\uff09\u548cIonis\u5728\u795e\u7ecf\u75be\u75c5\u9886\u57df\u8fbe\u6210\u4e86\u4e3a\u671f10\u5e74\u7684\u53cd\u4e49\u836f\u7269\u5408\u4f5c\u4ea4\u6613\u3002\u4e24\u5bb6\u516c\u53f8\u4e4b\u524d\u7684\u5408\u4f5c\u5f00\u53d1\u51fa\u4e86\u88ab\u5e7f\u6cdb\u7528\u4e8e\u810a\u9ad3\u6027\u808c\u840e\u7f29\u7684\u836f\u7269Spinraza\u3002\u8fd9\u6b21\uff0cIonis\u83b7\u5f97\u4ef7\u503c6.25\u4ebf\u7f8e\u5143\u7684\u80a1\u6743\u548c3.75\u4ebf\u7f8e\u5143\u7684\u524d\u671f\u4ed8\u6b3e\uff0c\u6bcf\u4e2a\u5408\u4f5c\u836f\u7269\u6700\u9ad8\u8fbe2.7\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\u548c\u8bb8\u53ef\u8d39\uff0c\u4ee5\u53ca\u6700\u9ad820%\u7684\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u57fa\u56e0\u6cf0\u514b\u548cLodo\u8fbe\u62109.69\u4ebf\u7f8e\u5143\u7684<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u57fa\u4e8e\u5fae\u751f\u7269DNA\u6d4b\u5e8f\u7684\u534f\u8bae<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u57fa\u56e0\u6cf0\u514b\uff08Genentech\uff09\u5c06\u4f7f\u7528Lodo\u7684\u57fa\u56e0\u7ec4\u6316\u6398\u548c\u751f\u7269\u5408\u6210\u96c6\u7fa4\u5e73\u53f0\u53d1\u73b0\u672a\u516c\u5f00\u9776\u70b9\u7684\u5019\u9009\u836f\u7269\u3002\u4ea4\u6613\u4ef7\u5305\u62ec\u672a\u62ab\u9732\u7684\u524d\u671f\u4ed8\u6b3e\uff0c\u6700\u9ad89.69\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002\u8be5\u5e73\u53f0\u57fa\u4e8e\u571f\u58e4\u4e2d\u7684\u5fae\u751f\u7269DNA\u5e8f\u5217\u4fe1\u606f\u6765\u53d1\u73b0\u751f\u7269\u6d3b\u6027\u5929\u7136\u4ea7\u7269\uff0c\u800c\u4e0d\u5fc5\u57f9\u517b\u5df2\u77e5\u7ec6\u83cc\u83cc\u682a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">Axovan 8.425\u4ebf\u7f8e\u5143\u83b7\u5f97Oxford<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u7528\u4e8e\u5e15\u91d1\u68ee\u75c5\u7684Prosavin<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">Axovant\u5bf9Oxford BioMedica\u7684ProSavin\u8868\u793a\u4e86\u5174\u8da3\u3002ProSavin\u662f\u4e00\u79cd\u57fa\u56e0\u7597\u6cd5\uff0c\u8868\u8fbe\u7f16\u7801\u591a\u5df4\u80fa\u5408\u6210\u6240\u9700\u9176\u7684\u4e09\u79cd\u57fa\u56e0\uff0c\u4f7f\u7528\u6162\u75c5\u6bd2\u8f6c\u79fb\u7cfb\u7edf\u548c\u7cbe\u7b80\u7684\u9a6c\u4f20\u67d3\u6027\u8d2b\u8840\u75c5\u6bd2\u8fdb\u884c\u4f20\u9012\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u5e15\u91d1\u68ee\u75c5\u7684III\u671f\u7814\u7a76\uff08\u56fe3\uff09\u3002\u4ea4\u6613\u8fd8\u5305\u62ec\u53e6\u4e00\u4e2a\u6f5c\u5728\u7684\u53d1\u73b0\u9636\u6bb5\u836f\u7269OXB-102\uff08\u73b0\u540d\u79f0\u4e3aAXO-Lenti-PD\uff09\u3002Oxford\u5c06\u6536\u52303000\u4e07\u7f8e\u5143\u524d\u671f\u6b3e\uff0c8.125\u4ebf\u7f8e\u5143\u91cc\u7a0b\u91d1\uff0c\u4ee5\u53ca7%-10%\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"text-align: left;white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 12px;box-sizing: border-box;\">\u7528\u4e8e\u5e15\u91d1\u68ee\u75c5\u7684\u7684AXO-Lenti-PD\uff08OXB-102\uff09\u548cProSavin<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: left;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img class=\"\"          style=\"vertical-align: middle;box-sizing: border-box;width: 558px;height: 315px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537925057.jpg\" alt=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\" title=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\"  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\/><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u8d5b\u8bfa\u83f2\u6295\u8d448.05\u4ebf\u7f8e\u5143\uff0c\u83b7\u5f97Translate\u7528\u4e8e<\/span><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u4e94\u79cd\u611f\u67d3\u7684mRNA\u75ab\u82d7<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8d5b\u8bfa\u83f2\uff08Sanofi\uff09\u5411Translate Bio\u652f\u4ed84500\u4e07\u7f8e\u5143\u524d\u671f\u6b3e\uff0c\u6700\u9ad8\u8fbe7.6\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\uff0c\u4ee5\u53ca\u9009\u62e9\u6743\u6267\u884c\u8d39\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\uff0c\u4f5c\u4e3a\u4ea4\u6362\uff0c\u5c06\u53ef\u4ee5\u4f7f\u7528Translate Bio\u7684mRNA\u5e73\u53f0\u5f00\u53d1\u7528\u4e8e\u4e94\u79cd\u672a\u62ab\u9732\u7684\u611f\u67d3\u75be\u75c5\u7684\u75ab\u82d7\u3002mRNA\u75ab\u82d7\u53ef\u4ee5\u9012\u9001\u7f16\u7801\u9776\u5411\u75c5\u539f\u4f53\u4efb\u4f55\u86cb\u767d\u7684\u6838\u82f7\u9178\u5e8f\u5217\u3002\u622a\u6b62\u76ee\u524d\uff0cTranslate\u81ea\u5df1\u7684mRNA\u75ab\u82d7\uff0cMRT-5201\uff08\u6ccc\u5c3f\u75be\u75c5\uff0c\u6c28\u9178\u8f6c\u6c28\u7532\u9170\u9176\u7f3a\u4e4f\u75c7\uff09\u548cMRT-5005\uff08\u56ca\u6027\u7ea4\u7ef4\u5316\uff09\u5df2\u7ecf\u53d6\u5f97\u826f\u597d\u7684\u8fdb\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u76d0\u91ce\u4e495.75\u4ebf\u7f8e\u5143\u8d2d\u4e70Sage\u7684SAGE-217\uff0c<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u7740\u773c\u4e8e\u65e5\u672c\u7684\u6291\u90c1\u75c7\u5e02\u573a<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u83b7\u5f97FDA\u7684\u7a81\u7834\u6027\u7597\u6cd5\u6307\u5b9a\u540e\u4e0d\u4e45\uff0cSage\u5c06\u5176\u7528\u4e8e\u91cd\u5ea6\u6291\u90c1\u75c7\u7684GABAA\u53d7\u4f53\u8c03\u8282\u795e\u7ecf\u6d3b\u6027\u7c7b\u56fa\u9187\u836f\u7269SAGE-217\u5728\u65e5\u672c\u3001\u53f0\u6e7e\u548c\u97e9\u56fd\u7684\u5e02\u573a\u6743\u76ca\u6388\u6743\u7ed9\u76d0\u91ce\u4e49\uff08Shionogi\uff09\u3002\u76d0\u91ce\u4e49\u627f\u8bfa\u652f\u4ed89000\u4e07\u7f8e\u5143\u524d\u671f\u6b3e\uff0c\u6700\u9ad8\u8fbe4.85\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002\u76ee\u524d\u8fd9\u4e2a\u836f\u7269\u5728II\u671f\u4e34\u5e8a\u9636\u6bb5\uff0c\u9884\u8ba1\u5c06\u57282024\u5e74\u8fbe\u523020\u4ebf\u7f8e\u5143\u4ee5\u4e0a\u7684\u5e74\u9500\u552e\u989d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u963f\u65af\u5229\u5eb7\u4ee55.46\u4ebf\u7f8e\u5143\u7684\u4ef7\u683c\u5c06<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u7cbe\u795e\u5206\u88c2\u75c7\u836f\u7269\u601d\u745e\u5eb7\u51fa\u552e\u7ed9\u7eff\u53f6\u5236\u836f<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u91cd\u65b0\u8c03\u6574\u6cbb\u7597\u9886\u57df\u6218\u7565\u540e\uff0c\u963f\u65af\u5229\u5eb7\u5c06\u7528\u4e8e\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u53cc\u76f8\u60c5\u611f\u969c\u788d\u7684\u8001\u836f\u601d\u745e\u5eb7\uff08Seroquel\uff09\u53ca\u5176\u7f13\u91ca\u5236\u5242\u5728\u67d0\u4e9b\u56fd\u5bb6\u7684\u6743\u76ca\u51fa\u552e\u7ed9\u7eff\u53f6\u5236\u836f\u7684\u9999\u6e2f\u5206\u516c\u53f8\u3002\u7eff\u53f6\u5c06\u4e3a\u6b64\u5c06\u652f\u4ed82.6\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\uff0c\u5e76\u57282020\u5e74\u524d\u652f\u4ed8\u53e6\u5916\u76842.86\u4ebf\u7f8e\u5143\u3002\u7eff\u53f6\u85c9\u6b64\u4ea4\u6613\u52a0\u5f3a\u5176\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e0a\u7684\u4ea7\u54c1\u7ebf\uff0c\u5c24\u5176\u662f\u5728\u4e2d\u56fd\u672c\u571f\u5e02\u573a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">Vifor 5.4\u4ebf\u7f8e\u5143\u83b7\u5f97Cara\u7684\u80be\u75c5\u836f\u7269Korsuva<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e13\u6ce8\u4e8e\u80be\u75c5\u836f\u7269\u7684Vifor\u83b7\u5f97\u4e86Cara\u7528\u4e8e\u6162\u6027\u80be\u75c5\u76f8\u5173\u7619\u75d2\u75c7\u7684Korsuva\uff08difelikefalin\uff09\u6ce8\u5c04\u5242\u9664\u7f8e\u56fd\u3001\u65e5\u672c\u548c\u97e9\u56fd\u4ee5\u5916\u7684\u5168\u7403\u6743\u76ca\u3002\u8fd9\u4e2a\u836f\u7269\u662f\u03ba\u963f\u7247\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u76ee\u524d\u6b63\u5728\u5f00\u5c55III\u671f\u7814\u7a76\uff0c\u7528\u4e8e\u8840\u6db2\u900f\u6790\u60a3\u8005\u7684\u76ae\u80a4\u7619\u75d2\u548c\u75bc\u75db\uff0c\u6700\u8fd1\u521a\u83b7\u5f97FDA\u7684\u7a81\u7834\u6027\u7597\u6cd5\u6307\u5b9a\u3002Cara\u5c06\u83b7\u5f975000\u4e07\u7f8e\u5143\u524d\u671f\u6b3e\uff0c2000\u4e07\u7f8e\u5143\u80a1\u6743\uff0c\u6700\u9ad8\u8fbe4.7\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><span style=\"color: rgb(122, 79, 214);\">&nbsp;<span style=\"letter-spacing: 0px;box-sizing: border-box;\">Microbiotica\u7528\u4e8eIBD\u6cbb\u7597\u7684\u5fae\u751f\u7269\u6807\u5fd7\u7269\u4e0e<\/span><\/span><\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><span style=\"letter-spacing: 0px;color: rgb(122, 79, 214);\">\u57fa\u56e0\u6cf0\u514b\u8fbe\u62105.34\u4ebf\u7f8e\u5143\u7684\u5408\u4f5c<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">Microbiotica\u4e0e\u57fa\u56e0\u6cf0\u514b\u8fbe\u6210\u5408\u4f5c\uff0c\u4f7f\u7528Microbiotica\u7684\u7cbe\u51c6\u7684\u5b8f\u57fa\u56e0\u7ec4\u5fae\u751f\u7269\u5e73\u53f0\u6765\u8bc4\u4f30\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff09\u60a3\u8005\u6837\u672c\u5bf9\u836f\u7269\u53cd\u5e94\u7684\u5fae\u751f\u7269\u6807\u5fd7\u7269\u6c34\u5e73\u3002\u8be5\u5e73\u53f0\u662f\u4e0e\u8868\u578b\u76f8\u5173\u7684\u5fae\u751f\u7269\u7ec4\u7279\u5f81\u6570\u636e\u5e93\uff0c\u80fd\u591f\u5728\u7ffb\u8bd1\u6a21\u578b\uff08\u5982\u4eba\u6e90\u5316\u5fae\u751f\u7269\u5c0f\u9f20\u6a21\u578b\uff09\u4e2d\u5bf9\u7ec6\u83cc\u8fdb\u884c\u751f\u7269\u5b66\u8bc4\u4f30\u3002Microbiotica\u5c06\u83b7\u5f97\u672a\u62ab\u9732\u7684\u524d\u671f\u6b3e\uff0c\u6700\u9ad8\u8fbe5.34\u4ebf\u7f8e\u5143\u7684\u7814\u7a76\u7ecf\u8d39\u548c\u91cc\u7a0b\u91d1\uff0c\u4ee5\u53ca\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u4e9a\u592a\u5730\u533a<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6388\u6743\u8bb8\u53ef\u4ea4\u6613\u5728\u6574\u4e2a\u4e9a\u592a\u5730\u533a\u90fd\u6709\u53d1\u751f\uff0c\u5176\u4e2d\u4e00\u4e9b\u662f\u9ad8\u989d\u4ea4\u6613\u3002\u4e2d\u56fd\u516c\u53f8\u4e3b\u5bfc\u4e86\u8fd9\u4e00\u5730\u533a\u7684\u4ea4\u6613\uff0c\u5171\u670917\u7b14\u4ea4\u6613\uff0c\u4ea4\u6613\u603b\u989d\u5927\u7ea620\u4ebf\u7f8e\u5143\u3002\u5176\u6b21\u662f\u65e5\u672c\u516c\u53f8\uff0c\u51718\u7b14\u4ea4\u6613\uff0c\u603b\u4ef7\u503c12\u4ebf\u7f8e\u5143\u3002\u9664\u4e86\u7eff\u53f6\u5236\u836f\u548c\u963f\u65af\u5229\u5eb75.46\u4ebf\u7f8e\u5143\u7684\u5408\u4f5c\uff0c\u4ee5\u53ca\u65e5\u672c\u76d0\u91ce\u4e49\u548cSage 5.75\u4ebf\u7f8e\u5143\u7684\u4ea4\u6613\u4ee5\u5916\uff0c\u8fd8\u6709\u5176\u4ed6\u4e00\u4e9b\u4ee4\u4eba\u611f\u5174\u8da3\u7684\u4ea4\u6613\u53d1\u751f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537925057.jpg\" alt=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\" title=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;<span style=\"font-size: 12px;text-align: left;letter-spacing: 0px;box-sizing: border-box;\">\u56fe4\uff1a2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u90e8\u5206\u4e9a\u592a\u5730\u533a\u7684\u516c\u53f8\u6240\u62ab\u9732\u7684\u4ea4\u6613\u91cf\u548c\u4ea4\u6613\u603b\u989d\uff08\u6765\u6e90\uff1a\u79d1\u777f\u552f\u5b89Cortellis\u7ade\u4e89\u60c5\u62a5\uff09<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e2d\u56fd\u516c\u53f8\u57fa\u77f3\u836f\u4e1a\u5c06Agios\u7684Tibsovo\uff08ivosidenib\uff09\u5f15\u5165\u4e2d\u56fd\u3002\u8fd9\u4e2a\u836f\u7269\u662f\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-1\u7a81\u53d8\u4f53\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u548c\u80c6\u7ba1\u764c\u3002Agios\u5c06\u6536\u52301200\u4e07\u7f8e\u5143\u7684\u524d\u671f\u6b3e\uff0c\u6700\u9ad8\u8fbe4.12\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002\u76ee\u524d\u8be5\u836f\u5df2\u7ecf\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8eAML\u3002\u4e4b\u524dAgios\u548c\u65b0\u57fa\uff08Celgene\uff09\u66fe\u5c31Tibsovo\u8fbe\u62103.17\u4ebf\u7f8e\u5143\u7684\u5408\u4f5c\u4ea4\u6613\uff0c\u4e4b\u540e2016\u5e745\u6708\u91cd\u65b0\u83b7\u5f97\u8fd9\u4e2a\u836f\u7269\u5728\u7f8e\u56fd\u4ee5\u5916\u5730\u533a\u7684\u6743\u76ca\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u57fa\u77f3\u8fd8\u4e0eBlueprint Medicines\u8fbe\u6210\u534f\u8bae\uff0c\u83b7\u5f97\u540e\u8005\u7684Kit\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242avapritinib\uff08III\u671f\uff0c\u80c3\u80a0\u764c\uff09\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f534\u6291\u5236\u5242BLU-554\uff08I\u671f\uff0c\u809d\u7ec6\u80de\u764c\uff09\u548cret\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08I\u671f\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff09\u5728\u4e2d\u56fd\u7684\u6743\u76ca\u3002Blueprint\u56e0\u6b64\u5c06\u83b7\u5f974000\u4e07\u7f8e\u5143\u524d\u671f\u6b3e\uff0c\u6700\u9ad8\u8fbe3.46\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\uff0c\u4ee5\u53ca\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e2d\u56fd\u751f\u7269\u5236\u836f\u516c\u53f8\u5fb7\u742a\u533b\u836f\u83b7\u5f97\u4e86Karyopharm\u76844\u6b3e\u4e34\u5e8a\u9636\u6bb5\u836f\u7269\u5728\u4e2d\u56fd\u7684\u6743\u76ca\uff1a\u8f93\u51fa\u86cb\u767d\uff08exportin\uff09\u6291\u5236\u5242verdinexor\uff0c\u7528\u4e8e\u75c5\u6bd2\u6027\u75be\u75c5\uff0c\u5904\u5728\u665a\u671f\u4e34\u5e8a\u9636\u6bb5\uff1b\u7528\u4e8e\u764c\u75c7\u7684selinexor\u3001eltanexor\u548cP21\u6d3b\u5316\u6fc0\u91764 \/\u70df\u9170\u80fa\u78f7\u9178\u6838\u7cd6\u8f6c\u79fb\u9176\u53cc\u91cd\u6291\u5236\u5242KPT-9274\u3002Karyopharm\u5c06\u6536\u52301200\u4e07\u7f8e\u5143\u524d\u671f\u6b3e\uff0c\u6700\u9ad8\u8fbe1.5\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\u4ee5\u53ca\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u767e\u5065\u83b7\u5f97\u4e86\u8d2d\u4e70\u65e5\u672c\u516c\u53f8TMS\u7684\u836f\u7269TMS-007\u7684\u9009\u62e9\u6743\u3002\u8fd9\u4e2a\u836f\u7269\u662fSMTP\uff08\u4ece\u4e1d\u72b6\u771f\u83ccStachybotrys microspora [SM]\u4e2d\u7eaf\u5316\u7684\u5316\u5408\u7269\uff0c\u5177\u4e09\u82ef\u4e59\u70ef\u57fa\u82ef\u915a [TP]\u7684\u7ed3\u6784\uff09\uff0c\u662f\u6297\u51dd\u836f\uff0c\u6b63\u5728\u8fdb\u884c\u7528\u4e8e\u6025\u6027\u5352\u4e2d\u7684II\u671f\u7814\u7a76\u3002\u767e\u5065\u5c06\u83b7\u5f97400\u4e07\u7f8e\u5143\u524d\u671f\u6b3e\uff0c1800\u4e07\u7f8e\u5143\u7684\u9009\u62e9\u6743\u8d39\u7528\uff0c\u6700\u9ad8\u8fbe3.35\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002\u8fd9\u4e2a\u73af\u6c27\u5316\u7269\u6c34\u89e3\u9176\u6291\u5236\u5242\u6700\u521d\u6765\u81ea\u4e8e\u4e1c\u4eac\u519c\u5de5\u5927\u5b66\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u4ea7\u54c1\u8fdb\u5165\u8180\u80f1\u75bc\u75db\u7efc\u5408\u5f81\/\u95f4\u8d28\u6027\u8180\u80f1\u708e\u7684III\u671f\u7814\u7a76\u540e\uff0cAquinox\u5c06rosiptor\u5728\u65e5\u672c\u548c\u5176\u4ed6\u4e00\u4e9b\u5173\u952e\u4e9a\u592a\u5730\u533a\u7684\u6743\u76ca\u51fa\u552e\u7ed9\u5b89\u65af\u6cf0\u6765\uff08Astellas\uff09\u3002rosiptor\u662f\u542b SH2 \u7ed3\u6784\u57df\u76845&#8217;\u808c\u9187\u78f7\u9178\u91761\u6fc0\u52a8\u5242\u3002Aquinox\u9884\u8ba1\u5c06\u83b7\u5f972500\u4e07\u7f8e\u5143\u524d\u671f\u6b3e\uff0c1.3\u4ebf\u7f8e\u5143\u91cc\u7a0b\u91d1\u4ee5\u53ca\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002\u4f46\u662f\uff0c\u7531\u4e8e\u5728\u6539\u5584\u8180\u80f1\u75bc\u75db\u4e0a\u7597\u6548\u4e0d\u663e\u8457\uff0c\u65e0\u79ef\u6781\u6570\u636e\uff0c\u836f\u7269\u5f00\u53d1\u505c\u6b62\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u517b\u4e50\u591a\uff08Yakult Honsha\uff09\u6b63\u5728\u5c06Verastem\u7684duvelisib\u5e26\u5165\u65e5\u672c\u5e02\u573a\uff0c\u4ef7\u683c\u5305\u62ec\u524d\u671f\u6b3e1000\u4e07\u7f8e\u5143\uff0c\u6700\u9ad8\u8fbe9000\u4e07\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002duvelisib\u662f\u78f7\u9178\u808c\u91873-\u6fc0\u9176\u03b4\u548c\u03b3 \u53cc\u6548\u6291\u5236\u5242\uff0c\u6b63\u5728\u7b49\u5f85\u7f8e\u56fd\u76d1\u7ba1\u673a\u6784\u6279\u51c6\u5176\u7528\u4e8e\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u548c\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;color: rgb(122, 79, 214);font-size: 14px;\">\u5f00\u5c55\u591a\u4e2a\u4ea4\u6613\u7684\u516c\u53f8<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\uff0c\u4e00\u4e9b\u5927\u578b\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5305\u62ec\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u3001\u8bfa\u548c\u8bfa\u5fb7\uff08Novo Nordisk\uff09\u548cBI\u90fd\u5f00\u5c55\u4e86\u591a\u7b14\u4ea4\u6613\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e13\u6ce8\u4e8e\u6d4b\u5e8f\u5206\u6790\u7684\u516c\u53f8Illumina\u6b63\u5728\u5f00\u53d1TruSight Oncology 500\u6d4b\u8bd5\u7684\u65b0\u7248\u672c\uff0c\u8fd9\u4e2a\u8bbe\u5907\u7528\u4e8e\u68c0\u6d4b\u9884\u6d4b\u6027\u57fa\u56e0\u7ec4\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5305\u62ec\u9488\u5bf9BMS\u7684\u80bf\u7624\u4ea7\u54c1\u7ebf\u7684\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08\u56fe5\uff09\u3002\u65b0\u4e00\u4ee3\u7684\u6d4b\u5e8f\u5e73\u53f0\u5305\u62ec\u68c0\u6d4b\u548c\u5206\u6790\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u7684DNA\u548cRNA\u7684\u8bd5\u5242\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: left;\">Idera\u6b63\u5728\u6d4b\u8bd5\u5176toll\u6837\u53d7\u4f539\u6fc0\u52a8\u5242IMO-2125\uff08tilsotolimod\uff09\u4e0eBMS\u7684Yervoy\uff08ipilimumab\uff09\u7528\u4e8e300\u591a\u540d\u96be\u6cbb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684III\u671f\u8bd5\u9a8c\uff08ILLUMINATE-301\uff09\u3002Oligonucleotid\u8fd9\u4e2a\u5be1\u805a\u6838\u9178\u836f\u7269\u8fc7\u53bb\u4e00\u76f4\u9762\u4e34\u5404\u79cd\u95ee\u9898\uff0c\u56e0\u4e3a\u4e0e\u5316\u7597\u8054\u5408\u6cbb\u7597\u9cde\u72b6\u7ec6\u80de\u764c\u7684I\u671f\u8bd5\u9a8c\u51fa\u73b0\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u548c\u7535\u89e3\u8d28\u5931\u8861\uff0c2011\u5e74\u5fb7\u56fd\u9ed8\u514b\u89e3\u9664\u4e86\u4e0eIdera\u8fbe\u6210\u7684\u4ef7\u503c4.2\u4ebf\u7f8e\u5143\u7684\u5408\u4f5c\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7f8e\u56fd\u516c\u53f8Advantagene\u4e13\u6ce8\u4e8e\u5f00\u53d1\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff0c\u76ee\u524d\u6b63\u5728\u5f00\u5c55\u8bc4\u4f30\u5176\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5ProstAtak\uff08aglatimagene besadenovec\uff09\u4e0e\u5168\u4eba\u6e90IgG4\u6297\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1-1\u6297\u4f53Opdivo\uff08\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff0cnivolumab\uff09\u7528\u4e8e\u6076\u6027\u795e\u7ecf\u80f6\u8d28\u7624\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u7684III\u671f\u8bd5\u9a8c\u3002ProstAtak\u662f\u8868\u8fbe\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\u80f8\u82f7\u6fc0\u9176\u57fa\u56e0\u7684\u817a\u75c5\u6bd2\u8f7d\u4f53\uff0c\u8fc7\u5ea6\u8868\u8fbe\u8be5\u57fa\u56e0\u7684\u80bf\u7624\u7ec6\u80de\u5bf9\u5b83\u654f\u611f\uff0c\u53ef\u4fc3\u8fdb\u65e0\u73af\u9e1f\u82f7\u6297\u75c5\u6bd2\u836f\u5982\u4f10\u6614\u6d1b\u97e6\u7684\u4f18\u5148\u6eb6\u7624\u4f5c\u7528\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">Flatiron Health\u5c06\u62d3\u5c552014\u5e74\u4e0eBMS\u8fbe\u6210\u7684\u5408\u4f5c\uff0c\u7ee7\u7eed\u534f\u52a9BMS\u7684\u7814\u7a76\u548c\u5f00\u53d1\uff0c\u4e3a\u8be5\u516c\u53f8\u63d0\u4f9b3\u5e74\u7684\u771f\u5b9e\u4e16\u754c\u6570\u636e\u3002Flatiron\u7684\u6570\u636e\u96c6\u6765\u81ea\u8d85\u8fc7265\u5bb6\u793e\u533a\u764c\u75c7\u8bca\u6240\uff0c6\u5bb6\u4e3b\u8981\u7684\u5b66\u672f\u7814\u7a76\u4e2d\u5fc3\u548c15\u5bb6\u80bf\u7624\u6cbb\u7597\u516c\u53f8\uff0c\u4e3a\u516c\u53f8\u51b3\u7b56\u63d0\u4f9b\u652f\u6301\uff0c\u5305\u62ec\u4e0a\u5e02\u540e\u6d3b\u52a8\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u548c\u9002\u5e94\u75c7\u62d3\u5c55\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6768\u68ee\uff08Janssen\uff09\u5c06\u8840\u6813\u836f\u7269BMS-986177\uff08\u4e00\u79cd\u6297\u8840\u6813\u5f62\u6210\u56e0\u5b50XIa\u6291\u5236\u5242\uff09\u7684\u7814\u7a76\u63a8\u8fdb\u5230\u7528\u4e8e\u9884\u9632\u4e8c\u7ea7\u5352\u4e2d\u7684II\u671f\u8bd5\u9a8c\uff0c\u5e76\u56e0\u6b64\u83b7\u5f97BMS\u7684\u672a\u62ab\u9732\u7684\u524d\u671f\u4ed8\u6b3e\u3001\u91cc\u7a0b\u91d1\u548c\u4e00\u90e8\u5206\u635f\u76ca\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537925058.jpg\" alt=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\" title=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"text-align: left;white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;font-size: 12px;box-sizing: border-box;\">\u56fe5\uff1a2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6BMS\u7684\u90e8\u5206\u4ea4\u6613\uff08\u6765\u6e90\uff1a\u79d1\u777f\u552f\u5b89Cortellis\u7ade\u4e89\u60c5\u62a5\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u8bfa\u548c\u8bfa\u5fb7<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\uff08UCSF\uff09\u6240\u62e5\u6709\u7684\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\uff08hESC\uff09\u6280\u672f\u5956\u7528\u4e8e\u521b\u5efahESC\u7ec6\u80de\u7cfb\uff0c\u4ee5\u5e2e\u52a9\u5f00\u53d1\u7528\u4e8e1\u578b\u7cd6\u5c3f\u75c5\u7684\u57fa\u4e8e\u5e72\u7ec6\u80de\u7684\u518d\u751f\u6cbb\u7597\u3002\u8bfa\u548c\u8bfa\u5fb7\u4e00\u76f4\u81f4\u529b\u4e8e\u5c06\u591a\u80fd\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u751f\u6210\u80f0\u5c9b\u7d20\u7684\u03b2\u7ec6\u80de\u3002\u8bfa\u548c\u8bfa\u5fb7\u8fd8\u4e0e\u675c\u514b-\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u533b\u5b66\u9662\u5171\u540c\u5f00\u53d1\u7528\u4e8e\u6162\u6027\u5fc3\u8870\u548c\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u7684\u5e72\u7ec6\u80de\uff0c\u4e0e\u745e\u5178\u9686\u5fb7\u5927\u5b66\u5408\u4f5c\u5f00\u53d1\u4eba\u91cd\u7ec4\u5c42\u7c98\u8fde\u86cb\u767d\u7ec6\u80de\u57f9\u517b\u57fa\u8d28\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">EpiDestiny\u4e0e\u8bfa\u548c\u8bfa\u5fb7\u5206\u4eab\u4e86\u7528\u4e8e\u9570\u72b6\u7ec6\u80de\u75c5\u548c\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u7684EPI-01\u5728\u5168\u7403\u7684\u6743\u76ca\u3002EPI-01\u5305\u62ec\u5730\u897f\u4ed6\u6ee8\uff08DNA\u7532\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242\uff09\u548c\u56db\u6c22\u5c3f\u82f7\uff08\u80de\u82f7\u8131\u6c28\u9176\u6291\u5236\u5242\uff09\uff0c\u53ef\u51cf\u5c11\u5730\u897f\u4ed6\u6ee8\u76f8\u5173\u7684\u6bd2\u6027\uff0c\u5e76\u5df2\u5728I\u671f\u8bd5\u9a8c\u4e2d\u663e\u793a\uff0c\u53ef\u589e\u52a0\u80ce\u513f\u8840\u7ea2\u86cb\u767d\u7684\u8868\u8fbe\u4ee5\u5bf9\u6297\u9570\u72b6\u7ec6\u80de\u8840\u7ea2\u86cb\u767d\u3002 EpiDestiny\u5c06\u652f\u4ed8\u8d85\u8fc74\u4ebf\u7f8e\u5143\u7684\u524d\u671f\u6b3e\u548c\u91cc\u7a0b\u7891\u4ed8\u6b3e\u4ee5\u53ca\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">Epigen\u7684\u6eb6\u8840\u78f7\u8102\u9178\u53d7\u4f531\uff08LPA1R\uff09\u62ee\u6297\u5242EPGN-696\u5438\u5f15\u4e86\u7cd6\u5c3f\u75c5\u548c\u6162\u6027\u80be\u75c5\u5e02\u573a\u7684\u5173\u6ce8\uff0c\u8be5\u836f\u5728\u80be\u75c5\u556e\u9f7f\u52a8\u7269\u6a21\u578b\u4e2d\u5c55\u793a\u4e86\u7528\u4e8e\u7ea4\u7ef4\u5316\u75be\u75c5\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8bfa\u548c\u8bfa\u5fb7\u5c06\u652f\u4ed8\u6700\u9ad8\u8fbe2\u4ebf\u7f8e\u5143\u7684\u524d\u671f\u6b3e\u3001\u91cc\u7a0b\u91d1\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u83b7\u5f97\u4e86\u8fd9\u4e2a\u836f\u7269\u3002\u4eca\u5e74\u7b2c\u4e00\u5b63\u5ea6\uff0c\u5728Ube Industries\u7684LPA1R\u62ee\u6297\u5242CP-2090\u53d1\u5e03\u4e86\u6709\u524d\u666f\u7684\u80ba\u7ea4\u7ef4\u5316\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u4e34\u5e8a\u524d\u6570\u636e\u540e\uff0cCuradim\u8d2d\u4e70\u4e86CP-2090\u3002\u8bfa\u548c\u8bfa\u5fb7\u7684\u4ea4\u6613\u548c\u8fd9\u7b14\u4ea4\u6613\u7c7b\u4f3c\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"text-align: left;white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;text-align: justify;box-sizing: border-box;\">\u7f8e\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8Kallyope\u6709\u516d\u4e2a\u9776\u5411\u4e8e\u80a0-\u8111\u8f74\u7684\u80bd\u7c7b\u5728\u4f53\u5185\u548c\u4f53\u5916\u9488\u5bf9\u80a5\u80d6\u75c7\u548c\u7cd6\u5c3f\u75c5\u8fdb\u884c\u4e86\u9a8c\u8bc1\uff0c\u8bfa\u548c\u8bfa\u5fb7\u83b7\u5f97\u4e86\u8fd9\u4e9b\u5728\u7814\u4ea7\u54c1\u8fdb\u4e00\u6b65\u5f00\u53d1\u7684\u9009\u62e9\u6743\u3002\u8bfa\u548c\u8bfa\u5fb7\u65e8\u5728\u901a\u8fc7\u786e\u5b9aKallyope\u7ed8\u5236\u7684\u80a0-\u8111\u56de\u8def\u7684\u9776\u70b9\uff0c\u7c4d\u7740\u64cd\u63a7\u80a0\u9053\u6765\u5f71\u54cd\u5927\u8111\u6d3b\u52a8\u3002Kallyope\u5728\u8fd9\u7b14\u4ea4\u6613\u4e2d\u83b7\u5f97\u4e86\u672a\u516c\u5f00\u91d1\u989d\u7684\u524d\u671f\u6b3e\u3001\u7814\u7a76\u7ecf\u8d39\u3001\u8bb8\u53ef\u8d39\u3001\u91cc\u7a0b\u91d1\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u52c3\u6797\u683c\u6bb7\u683c\u7ff0<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u725b\u6d25\u5927\u5b66\uff08The University of Oxford\uff09\u6b63\u5728\u8fdb\u884c\u4e00\u9879\u5927\u578b\u7684Jardiance\uff08\u6069\u683c\u5217\u51c0\uff09\u7528\u4e8e\u6162\u6027\u80be\u75c5\uff08\u6709\u6216\u65e0\u7cd6\u5c3f\u75c5\uff09\u7684III\u671f\u7814\u7a76\uff08EMPA-KIDNEY\uff09\u3002BI\u53ca\u5176\u5408\u4f5c\u4f19\u4f34\u793c\u6765\u5e0c\u671b\u80fd\u591f\u62d3\u5c55\u8fd9\u4e2a\u5df2\u7ecf\u5e7f\u6cdb\u4f7f\u7528\u7684\u7cd6\u5c3f\u75c5\u836f\u7269\u7684\u9002\u5e94\u75c7\u3002Jardiance\u662f\u94a0-\u8461\u8404\u7cd6\u534f\u540c\u8f6c\u8fd0\u86cb\u767d2\u6291\u5236\u5242\uff0c\u5c06\u57285000\u540d\u6210\u5e74\u4eba\u4e2d\u8bc4\u4f30\u662f\u5426\u80fd\u51cf\u5c11\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u6216\u5ef6\u7f13\u80be\u75c5\u8fdb\u5c55\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4f4d\u4e8e\u82f1\u56fd\u5251\u6865\u7684Bactevo\u6b63\u5728\u91c7\u7528\u57fa\u4e8e\u6db2\u6ef4\u7684\u5fae\u6d41\u4f53\u5168\u96c6\u6210\u836f\u7269\u5f15\u64ce\uff08Totally Integrated Medicines Engine\uff09\u5e73\u53f0\uff0c\u4ece\u8d85\u8fc71000\u79cd\u4e0d\u540c\u7684\u7ec6\u83cc\u7a81\u53d8\u4f53\u5e93\u4e2d\u5efa\u7acb\u533b\u5b66\u76f8\u5173\u7684\u65e0\u6807\u8bb0\u5206\u5b50\uff0c\u5e76\u7b5b\u9009\u5929\u7136\u5b9e\u4f53\u3002BI\u652f\u4ed8\u672a\u516c\u5f00\u91d1\u989d\u7684\u524d\u671f\u6b3e\u3001\u7814\u7a76\u7ecf\u8d39\u548c\u91cc\u7a0b\u91d1\u83b7\u5f97\u8fd9\u4e2a\u5e73\u53f0\u7684\u4f7f\u7528\u6743\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">BI\u98ce\u9669\u6295\u8d44\u57fa\u91d1\uff08BI Venture Fund\uff09\u5bf9Topas\u8fdb\u884c2100\u4e07\u7f8e\u5143A\u8f6e\u6295\u8d44\u540e\uff0cTopas\u4e0eBI\u5c31\u81ea\u8eab\u514d\u75ab\u4ea7\u54c1\u7ec4\u5408\u8fbe\u6210\u5408\u4f5c\u3002Topas\u662f\u4eceEvotec\u5206\u62c6\u51fa\u6765\u7684\uff0c\u4e13\u6ce8\u4e8e\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u516c\u53f8\uff0c\u6b63\u5728\u4f7f\u7528\u5176\u5e73\u53f0\u5f00\u53d1\u8d1f\u8f7d\u80bd\u7684\u7eb3\u7c73\u7c92\u5b50\uff0c\u8be5\u7eb3\u7c73\u7c92\u5b50\u9009\u62e9\u6027\u5730\u9776\u5411\u4e8e\u809d\u7aa6\u5185\u76ae\u7ec6\u80de\uff08LSECs\uff09\u4ee5\u6a21\u62df\u8840\u6e90\u6027\u6297\u539f\uff0c\u5e76\u751f\u6210\u6291\u5236\u4e0d\u9700\u8981\u7684\u514d\u75ab\u53cd\u5e94\u7684\u6297\u539f\u7279\u5f02\u6027\u8c03\u8282T\u7ec6\u80de\u30022017\u5e748\u6708\u793c\u6765\u4e0eTopas\u8fbe\u6210\u4e86\u4e00\u9879\u7c7b\u4f3c\u7684\u534f\u8bae\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u91cc\u7a0b\u91d1<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u7684\u4ea4\u6613\u4e2d\uff0c\u6536\u5230\u91cc\u7a0b\u91d1\u6700\u591a\u7684\u4ea4\u6613\u6536\u6b3e\u65b9\u5305\u62ecPortola\u3001Incyte\u3001Exelixis\u548cRegenxbio\uff08\u88681\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537925059.jpg\" alt=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\" title=\"\u751f\u547d\u79d1\u5b66\u9886\u57df\u503c\u5f97\u5173\u6ce8\u7684\u6388\u6743\u4ea4\u6613\u8bb8\u53ef|2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 12px;box-sizing: border-box;\">\u88681\uff1a2018\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u6536\u5230\u91cc\u7a0b\u91d1\u6700\u9ad8\u7684\u4ea4\u6613\uff08\u6765\u6e90\uff1a\u79d1\u777f\u552f\u5b89Cortellis\u7ade\u4e89\u66f4\u60c5\u62a5\uff09<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728FDA\u6279\u51c6\u4e86Andexxa\u540e\uff0cPortola\u4eceHealthCare Royalty Partners\uff08HCR\uff09\u83b7\u5f97\u4e861\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u91d1\u3002Andexxa\u662f\u4e00\u79cd\u51dd\u8840\u5242\uff0c\u7528\u4e8e\u9006\u8f6c\u63a5\u53d7\u6297\u8840\u6813\u836f\u7269Xarelto\u6216Eliquis\u540e\u51fa\u73b0\u5371\u53ca\u751f\u547d\u6216\u65e0\u6cd5\u63a7\u5236\u7684\u51fa\u8840\u30022017\u5e742\u6708\uff0cHCR\u4ee51.5\u4ebf\u8d2d\u4e70\u4e86Portola\u8fd9\u4e2a\u836f\u7269\u7684\u6743\u76ca\uff0c\u9884\u8ba12024\u5e74Andexxa\u7684\u9500\u552e\u989d\u5c06\u8fbe\u523010\u4ebf\u7f8e\u5143\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7f8e\u56fd\u6279\u51c6Olumiant\u7528\u4e8e\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u540e\uff0c\u793c\u6765\u652f\u4ed81\u4ebf\u7f8e\u5143\u7ed9Incyte\u30022009\u5e7412\u6708\uff0c\u793c\u6765\u4ee57.55\u4ebf\u7f8e\u5143\u7684\u4ef7\u683c\u83b7\u5f97\u4e86\u8fd9\u4e2ajanus\u6fc0\u91761\/2\u6291\u5236\u5242\u7684\u6743\u76ca\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u591a\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242Cabometyx\u5728\u6b27\u76df\u83b7\u6279\u62d3\u5c55\u9002\u5e94\u75c7\uff0c\u7528\u4e8e\u4e2d\u4f4e\u98ce\u9669\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\uff0c\u89e6\u53d1\u4e86\u76ca\u666e\u751f\uff08Ipsen\uff09\u5411Exelixis\u652f\u4ed85000\u4e07\u7f8e\u5143\u91cc\u7a0b\u91d1\u30022016\u5e742\u6708\u76ca\u666e\u751f\u4ee58.55\u4ebf\u7f8e\u5143\u8d2d\u4e70\u4e86\u8fd9\u4e2a\u836f\u7269\u7684\u6743\u76ca\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8bfa\u534e\uff08Novartis\uff09\u8d2d\u4e70AveXis\u7684Regenxbio\u540e\uff0cAveXis\u52a0\u901f\u83b7\u5f97\u4e861\u4ebf\u7f8e\u5143\u7684\u6388\u6743\u8bb8\u53ef\u8d39\uff086000\u4e07\u7f8e\u5143\u7684\u5e74\u8d39\u548c4000\u4e07\u7f8e\u5143\u7684\u5546\u4e1a\u91cc\u7a0b\u91d1\uff09\u3002Regenxbio\u662f\u4e00\u79cd\u5305\u542b\u751f\u5b58\u8fd0\u52a8\u795e\u7ecf\u51432\u57fa\u56e0cDNA\u7684\u57fa\u56e0\u7597\u6cd5\uff0c\u5229\u7528\u817a\u76f8\u5173\u75c5\u6bd2\u8840\u6e05\u578b9\u8f7d\u4f53\u6765\u4f20\u9012AVXS-101\uff0c\u8fd9\u4e00\u7597\u6cd5\u6b63\u5728\u8fdb\u884c\u6cbb\u7597\u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u30022014\u5e743\u6708\u53cc\u65b9\u8fbe\u6210\u4ea4\u6613\uff0c\u76ee\u524d\u4ea4\u6613\u4ef7\u503c\u5df2\u7ecf\u8d85\u8fc7\u4e862.7\u4ebf\u7f8e\u5143\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u764c\u75c7\u6cbb\u7597\u836f\u7269CX-2029\u5728\u7f8e\u56fd\u7684IND\u7533\u8bf7\u83b7\u5f97\u6279\u51c6\u4ee5\u540e\uff0c\u827e\u4f2f\u7ef4\uff08AbbVie\uff09\u4e0d\u5f97\u4e0d\u5411CytomX\u652f\u4ed82500\u4e07\u7f8e\u5143\u30022016\u5e744\u6708\u4e24\u5bb6\u516c\u53f8\u9488\u5bf9\u8fd9\u4e2a\u5f53\u65f6\u5904\u4e8e\u53d1\u73b0\u9636\u6bb5\u7684\u9776\u5411\u4e8eCD-71\u7684Probody\u6297\u4f53\u5171\u8f6d\u7269\u8fbe\u6210\u4e86\u4ef7\u503c4.9\u4ebf\u7f8e\u5143\u7684\u4ea4\u6613\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7f8e\u56fdFDA\u6279\u51c6\u4e86Rekynda\u7684NDA\uff0c\u89e6\u53d1AMAG\u652f\u4ed8Palatin 2000\u4e07\u7f8e\u5143\u3002Rekynda\u7528\u4e8e\u6cbb\u7597\u66f4\u5e74\u671f\u6cbb\u7597\u4e2d\u7684\u6027\u6b32\u51cf\u9000\uff0c\u662f\u9ed1\u76ae\u8d28\u7d20\uff08elanocortin\uff09MCR-4\u6fc0\u52a8\u5242\u30022017\u5e741\u6708\u4e24\u5bb6\u516c\u53f8\u8fbe\u6210\u534f\u8bae\uff0cAMAG\u83b7\u5f97\u8fd9\u4e2a\u836f\u7269\u5728\u5317\u7f8e\u7684\u6743\u76ca\uff0c\u4ea4\u6613\u4ef7\u683c\u4e3a4.65\u4ebf\u7f8e\u5143\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">talazoparib\u83b7\u5f97\u7f8e\u56fdFDA\u7684NDA\u6279\u51c6\uff0c\u5e76\u63a5\u53d7\u4e86\u8fd9\u4e2a\u836f\u7684MAA\uff0cBioMarin\u56e0\u6b64\u4ece\u8f89\u745e\u83b7\u5f972000\u4e07\u7f8e\u5143\u3002talazoparib\u662f\u591a\u805aADP\u6838\u7cd6\u805a\u5408\u91761\/2\u6291\u5236\u5242\uff0c\u7528\u4e8e\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u30022015\u5e7410\u6708\u8f89\u745e\u4ee55.7\u4ebf\u7f8e\u5143\u83b7\u5f97\u4e86\u8fd9\u4e2a\u836f\u7269\u7684\u6743\u76ca\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u9009\u62e9\u6743\u548c\u7ec8\u6b62\u4ea4\u6613<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u767e\u5065\u884c\u4f7f\u9009\u62e9\u6743\uff0c\u4e3aNeurimmune\u7684\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u836f\u7269aducanumab\u652f\u4ed85000\u4e07\u7f8e\u5143\uff0c\u540c\u65f6\u5c06\u8fd9\u4e2a\u836f\u7269\u7684\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u964d\u4e865%\u30022017\u5e7410\u6708\uff0c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u5df2\u7ecf\u964d\u4e8615%\u3002\u8fd9\u7b14\u4ea4\u6613\u662f2007\u5e7411\u6708\u7b7e\u7f72\u7684\uff0c\u5f53\u65f6\u534f\u8bae\u4ef7\u503c3.8\u4ebf\u7f8e\u5143\uff0c\u73b0\u5728\u589e\u52a0\u81f35.8\u4ebf\u7f8e\u5143\u3002\u76ee\u524daducanumab\u6b63\u5728\u8fdb\u884cIII\u671f\u7814\u7a76\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u5ba1\u67e5\u4e86\u521d\u6b65\u7684\u80c3\u80a0\u9053\u8010\u53d7\u6027\u6570\u636e\u540e\uff0c\u767e\u5065\u6267\u884c\u9009\u62e9\u6743\uff0c\u652f\u4ed85000\u4e07\u7f8e\u5143\uff0c\u7ee7\u7eed\u4e0eAlkermes\u5408\u4f5c\u5f00\u53d1ALKS-8700\u30022017\u5e7411\u6708\u53cc\u65b9\u8fbe\u6210\u8fd9\u9879\u4ef7\u503c2.28\u4ebf\u7f8e\u5143\u7684\u4ea4\u6613\u3002ALKS-8700\u662f\u5bcc\u9a6c\u9178\u5355\u7532\u916f\u7684\u524d\u836f\uff0c\u6b63\u5728\u8fdb\u884c\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684III\u671f\u7814\u7a76\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">Vifor\u884c\u4f7f\u9009\u62e9\u6743\uff0c\u652f\u4ed82150\u4e07\u7f8e\u5143\uff0c\u6269\u5927CCX-168\uff08avacopan\uff09\u5728\u4e2d\u56fd\u7684\u5546\u4e1a\u5316\u6743\u3002CCX-168\u662fChemoCentryx\u5f00\u53d1\u76845a\u53d7\u4f531\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u6b63\u5728\u7b49\u5f85\u6b27\u76df\u6279\u51c6\u7528\u4e8e\u8840\u7ba1\u708e\u7684\u6cbb\u7597\u30022016\u5e745\u6708Vifor\u4ee55.95\u4ebf\u7f8e\u5143\u83b7\u5f97\u8fd9\u4e2a\u836f\u7269\u5728\u591a\u4e2a\u5730\u65b9\u7684\u6743\u76ca\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u51fa\u4e8e\u8d22\u52a1\u539f\u56e0\u8ba1\u5212\u7ed3\u675f\u5728\u7f8e\u56fd\u7684\u5546\u4e1a\u8fd0\u8425\u540e\uff0cVernalis\u5411Tris Pharma\u652f\u4ed81000\u4e07\u7f8e\u5143\uff0c\u5c06\u5305\u62ecTuzistra XR\uff08\u53ef\u5f85\u56e0-\u78fa\u5316\u4e8c\u4e59\u70ef\u82ef-\u4e59\u70ef\u82ef\u5171\u805a\u7269\/\u6c2f\u82ef\u90a3\u654f-\u78fa\u5316\u4e8c\u4e59\u70ef\u82ef-\u4e59\u70ef\u82ef\u5171\u805a\u7269 \uff09\u5728\u5185\u7684\u611f\u5192\u5236\u5242\u7684\u6743\u76ca\u9000\u56de\u7ed9Tris Pharma\u3002\u4e24\u5bb6\u516c\u53f8\u57282012\u5e742\u6708\u8fbe\u6210\u4ef7\u503c8900\u4e07\u7f8e\u5143\u7684\u5408\u4f5c\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e2d\u5916\u5236\u836f\uff08Chugai\uff09\u5c06\u764c\u75c7\u836fZepsyre\u5728\u65e5\u672c\u7684\u6743\u76ca\u9000\u56de\u7ed9PharmaMar\uff0c\u7ec8\u6b62\u8d39\u4e3a360\u4e07\u7f8e\u5143\uff0c\u539f\u56e0\u672a\u62ab\u9732\u3001\u4e2d\u5916\u5236\u836f\u4e8e2016\u5e7412\u6708\u4ee51.35\u4ebf\u7f8e\u5143\u83b7\u5f97\u4e86\u8fd9\u4e2aIII\u671f\u9636\u6bb5\u7684RNA\u805a\u5408\u9176II\u6291\u5236\u5242\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">Aptose\u6267\u884c\u9009\u62e9\u6743\uff0c\u652f\u4ed8500\u4e07\u7f8e\u5143\u7ed9CrystalGenomics\uff0c\u83b7\u5f97CG-806\u5728\u5168\u7403\u7684\u72ec\u5bb6\u6743\u76ca\u3002CG-806\u662fBruton\u916a\u6c28\u9178\u6fc0\u9176\u548cFMS\u6837\u916a\u6c28\u9178\u6fc0\u91763\u53cc\u91cd\u6291\u5236\u5242\uff0c\u53ef\u7528\u4e8e\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u548cB\u7ec6\u80de\u6076\u6027\u80bf\u7624\uff0c\u76ee\u524d\u5c1a\u5904\u5728\u53d1\u73b0\u9636\u6bb5\u3002\u8fd9\u7b14\u4ea4\u6613\u4e8e2016\u5e743\u6708\u8fbe\u6210\uff0c\u5f53\u65f6\u7684\u4ef7\u503c\u4e3a3.02\u4ebf\u7f8e\u5143\uff0c\u76ee\u524d\u589e\u52a0\u81f34.24\u4ebf\u7f8e\u5143\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u7f8e\u56fd\u4e0a\u5e02\u6cbb\u7597\u963f\u7247\u7c7b\u4f9d\u8d56\u75c7\u7684Probuphine\u540e\uff0cBraeburn\u5c06\u8fd9\u4e2a\u4e01\u4e19\u8bfa\u5561\u7684\u6301\u7eed\u91ca\u653e\u690d\u5165\u8bbe\u5907\u7684\u6743\u76ca\u9000\u56de\u7ed9Titan\uff0c\u4ef7\u683c\u4e3a100\u4e07\u7f8e\u5143\uff0c\u539f\u56e0\u662fFDA\u5728\u5b8c\u6574\u7b54\u590d\u4fe1\u4e2d\u79f0\uff0cFDA\u8ba4\u4e3aBraeburn\u7684\u6ce8\u5c04\u7528\u4e01\u4e19\u8bfa\u5561\u4f1a\u5bf9\u5176\u8425\u9500\u6d3b\u52a8\u4ea7\u751f\u8d1f\u9762\u5f71\u54cd\u3002\u53cc\u65b9\u4e8e2012\u5e7412\u6708\u8fbe\u6210\u8fd9\u4e2a\u4ef7\u503c2.8\u4ebf\u7f8e\u5143\u7684\u4ea4\u6613\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;margin-top: -6px;margin-bottom: -6px;box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);padding-left: 8px;padding-right: 8px;color: rgb(166, 91, 203);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);font-size: 14px;\">\u5c55\u671b2018\u5e74\u7b2c\u4e09\u5b63\u5ea6<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"overflow: hidden;box-sizing: border-box;\">\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: left;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<section style=\"padding: 3px;background-color: rgb(255, 255, 255);float: right;box-sizing: border-box;\">\n<section style=\"width: 5px;height: 5px;box-sizing: border-box;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(166, 91, 203);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">2018\u5e74\u7b2c\u4e09\u5b63\u5ea6\u521d\uff0c\u65b0\u7684\u4ea4\u6613\u6301\u7eed\u589e\u52a0\u81f3Cortellis\u7ade\u4e89\u60c5\u62a5\u4ea4\u6613\u62a5\u544a\u30027\u6708\u521d\u6709\u4ee5\u4e0b\u51e0\u7b14\u91cd\u8981\u7684\u4ea4\u6613\uff1a<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: 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