{"id":46018,"date":"2018-09-19T01:00:00","date_gmt":"2018-09-26T01:24:22","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e7%bd%95%e8%a7%81%e7%97%85%e8%8d%af%e7%89%a9%e7%9a%84%e6%8c%91%e6%88%98%e4%b8%8e%e6%9c%ba%e4%bc%9a%e6%9a%a8%e5%af%b9%e4%b8%ad%e5%9b%bd%e8%8d%af%e4%bc%81%e7%9a%84%e5%90%af%e7%a4%ba\/"},"modified":"2018-09-26T09:24:31","modified_gmt":"2018-09-26T01:24:31","slug":"%e7%bd%95%e8%a7%81%e7%97%85%e8%8d%af%e7%89%a9%e7%9a%84%e6%8c%91%e6%88%98%e4%b8%8e%e6%9c%ba%e4%bc%9a%e6%9a%a8%e5%af%b9%e4%b8%ad%e5%9b%bd%e8%8d%af%e4%bc%81%e7%9a%84%e5%90%af%e7%a4%ba","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/46018\/","title":{"rendered":"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;text-align: justify;background-image: none;white-space: normal;box-sizing: border-box;\">\u672c\u6587\u4f5c\u8005\uff1a\u8d75\u5b87\u8587<\/p>\n<p style=\"margin: 14px 0px;padding: 0px;text-align: justify;background-image: none;white-space: normal;box-sizing: border-box;\">\u7b2c\u4e03\u5c4a\u4e2d\u56fd\u7f55\u89c1\u75c5\u9ad8\u5cf0\u8bba\u575b\u57282018\u5e749\u670814-16\u65e5\u4e8e\u4e0a\u6d77\u4e3e\u529e\uff0c\u6b64\u8bba\u575b\u7684\u76ee\u7684\u5728\u4e8e\u589e\u52a0\u5bf9\u4e8e\u7f55\u89c1\u75c5\u7684\u7406\u89e3\u548c\u8ba4\u8bc6\u3002\u5728\u6b64\u4e4b\u524d\uff0c\u79d1\u777f\u552f\u5b89\u751f\u547d\u79d1\u5b66\u4ea7\u54c1\u4e0e\u670d\u52a1\u4e13\u5bb6\u8d75\u5b87\u8587\u4e8e8\u6708\u521d\u7684Cortellis\u5927\u8bb2\u5802\u4e2d\u66fe\u5bf9\u7f55\u89c1\u75c5\u53ca\u7f55\u89c1\u75c5\u836f\u7269(\u4e5f\u6307\u5b64\u513f\u836f\uff0c\u5373orphan drug)\u5728\u4e2d\u7684\u53d1\u5c55\u73b0\u51b5\u8fdb\u884c\u8ba8\u8bba\uff0c\u672c\u6587\u8282\u9009\u81ea\u8be5\u7f51\u7edc\u4f1a\u8bae\u5185\u5bb9\uff08\u6587\u672b\u53ef\u5728\u7ebf\u89c2\u770b\u89c6\u9891\u56de\u653e\uff09\uff0c\u4e14\u7279\u522b\u611f\u8c22\u79d1\u777f\u552f\u5b89\u751f\u547d\u79d1\u5b66\u8d44\u6df1\u7f16\u7f09Shyama Ghosh\u5973\u58eb\u5171\u540c\u5b8c\u6210\u672c\u6587\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;padding-right: 6px;vertical-align: top;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-color: rgb(166, 91, 203);background-image: none;color: rgb(166, 91, 203);margin-right: 6px;border-bottom-width: 1px;border-bottom-style: solid;box-sizing: border-box;\">\n<p style=\"margin: 16px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);\">1. \u5168\u7403\u4e3b\u8981\u836f\u653f\u5e02\u573a\u7f55\u89c1\u75c5\u836f\u7269\u653f\u7b56<\/span><\/p>\n<\/section>\n<section style=\"border-color: rgb(166, 91, 203);width: 0px;height: 22px;background-image: none;margin-top: -21px;margin-left: auto;border-left-width: 1px;border-left-style: solid;box-sizing: border-box;transform: rotate(30deg);-webkit-transform: rotate(30deg);-moz-transform: rotate(30deg);-o-transform: rotate(30deg);transform-origin: 0px 50% 0px;-webkit-transform-origin: 0px 50% 0px;-moz-transform-origin: 0px 50% 0px;-o-transform-origin: 0px 50% 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\">\u5728\u4eca\u5e74(2018)\u76845\u670822\u65e5\uff0c\u4e2d\u56fd\u516c\u5e03\u4e86\u7b2c\u4e00\u6279\u7f55\u89c1\u75c5\u76ee\u5f55\uff0c\u5f53\u4e2d\u5171\u5217\u51fa121\u4e2a\u7f55\u89c1\u75c5\uff1b\u6b64\u4e3e\u88ab\u89c6\u4e3a\u4e2d\u56fd\u653f\u5e9c\u91cd\u89c6\u7f55\u89c1\u75c5\u53ca\u76f8\u5e94\u7f55\u89c1\u75c5\u836f\u7269\u5e02\u573a\u9700\u6c42\u7684\u7b2c\u4e00\u6b65\u3002\u5982\u56fe1\u6240\u793a\uff0c\u5728\u4e2d\u56fd\u76ee\u524d\u53ef\u7ecf\u7531\u7279\u6b8a\u5ba1\u6279\u7684\u5feb\u901f\u901a\u9053\u52a0\u901f\u7f55\u89c1\u75c5\u836f\u4e0a\u5e02 (\u53c2\u80032017\u5e74126\u53f7\u6587)\uff0c\u5176\u4ed6\u4e3b\u8981\u7684\u836f\u653f\u5e02\u573a\u5982\u7f8e\u56fd\u3001\u6b27\u76df\u53ca\u6fb3\u6d32\u7b49\uff0c\u4e5f\u6709\u76f8\u5e94\u63a8\u52a8\u65b0\u836f\uff0c\u7279\u522b\u662f\u7f55\u89c1\u75c5\u836f\u7269\u4e0a\u5e02\u7684\u7279\u6b8a\u5ba1\u6279\u53ca\u52a0\u901f\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537925063.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;text-align: justify;background-image: none;white-space: normal;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u56fe1:\u5168\u7403\u4e3b\u8981\u5e02\u573a\u52a0\u901f\u836f\u7269\u4e0a\u5e02(\u542b\u7f55\u89c1\u75c5)\u7684\u7279\u6b8a\u5ba1\u6279\u673a\u5236 (\u8d44\u6599\u6765\u6e90: Cortellis\u6cd5\u89c4\u60c5\u62a5)<\/span><br style=\"background-image: none;box-sizing: border-box;\"  \/><\/p>\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 14px;box-sizing: border-box;\">\u88681\u5217\u4e3e\u4e86\u7f8e\u56fd\u3001\u6b27\u6d32\u53ca\u65e5\u672c\u4e09\u4e2a\u4e3b\u8981\u5e02\u573a\u53d1\u5c55\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6cd5\u89c4\u53ca\u9f13\u52b1\u63aa\u65bd\u3002<\/span><br style=\"background-image: none;box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537925064.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: left;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;padding-right: 6px;vertical-align: top;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-color: rgb(166, 91, 203);background-image: none;color: rgb(166, 91, 203);margin-right: 6px;border-bottom-width: 1px;border-bottom-style: solid;box-sizing: border-box;\">\n<p style=\"margin: 0px;text-align: justify;text-justify: inter-ideograph;\"><span style=\"color: rgb(0, 0, 0);font-size: 12px;\"><span lang=\"ZH-CN\" style=\"margin: 0px;font-family: \u5b8b\u4f53;font-size: 12px;\">\u8868<span style=\"\">1:<\/span>\u7f8e\u56fd\u3001\u6b27\u6d32\u53ca\u65e5\u672c\u53d1\u5c55\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6cd5\u89c4\u53ca\u9f13\u52b1\u63aa\u65bd<\/span><span style=\"margin: 0px;\" microsoft=\"microsoft\" px=\"px\" jhenghei=\"jhenghei\"> (<\/span><span lang=\"ZH-CN\" style=\"margin: 0px;font-family: \u5b8b\u4f53;font-size: 12px;\">\u8d44\u6599\u6765\u6e90<\/span><span style=\"margin: 0px;\" microsoft=\"microsoft\" px=\"px\" jhenghei=\"jhenghei\">: Cortellis <\/span><span lang=\"ZH-CN\" style=\"margin: 0px;font-family: \u5b8b\u4f53;font-size: 12px;\">\u6cd5\u89c4\u60c5\u62a5<\/span><span style=\"margin: 0px;\" microsoft=\"microsoft\" px=\"px\" jhenghei=\"jhenghei\">)<\/span><\/span><br  \/><\/p>\n<p style=\"margin: 16px 0px;padding: 0px;text-align: center;background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);\">2. \u7f55\u89c1\u75c5\u836f\u7269\u5728\u7f8e\u56fdFDA\u7684\u83b7\u6279\u8d8b\u52bf<\/span><\/p>\n<\/section>\n<section style=\"border-color: rgb(166, 91, 203);width: 0px;height: 22px;background-image: none;margin-top: -21px;margin-left: auto;border-left-width: 1px;border-left-style: solid;box-sizing: border-box;transform: rotate(30deg);-webkit-transform: rotate(30deg);-moz-transform: rotate(30deg);-o-transform: rotate(30deg);transform-origin: 0px 50% 0px;-webkit-transform-origin: 0px 50% 0px;-moz-transform-origin: 0px 50% 0px;-o-transform-origin: 0px 50% 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\">\u7f55\u89c1\u75c5\u6216\u8bb8\u6bd4\u60a8\u6211\u60f3\u8c61\u7684\u66f4\u666e\u904d\uff0c\u6839\u636e\u7edf\u8ba1\uff0c\u76ee\u524d\u7ea6\u67097000 \u79cd\u7f55\u89c1\u75c5[1]\uff0c\u5168\u7403\u7f79\u60a3\u7f55\u89c1\u75c5\u7684\u4eba\u53e3\u7ea6\u67093\u4ebf\u4eba\uff0c80%\u7684\u7f55\u89c1\u75c5\u548c\u57fa\u56e0\u6709\u5173\uff0c\u800c50%\u7684\u7f55\u89c1\u75c5\u60a3\u8005\u662f\u513f\u7ae5\u3002\u7f8e\u56fdFDA\u57281983\u5e74\u9881\u5e03\u4e86\u5b64\u513f\u836f\u6cd5\u6848\u540e\uff0c\u8fc4\u4eca\u7ea6\u6709450\u4e2a\u7f55\u89c1\u75c5\u836f\u7269\u83b7\u6279\u4e0a\u5e02\uff0c\u5176\u4e2d\u90e8\u5206\u7684\u836f\u7269\u662f\u900f\u8fc7\u53d6\u5f97\u7f55\u89c1\u75c5\u836f\u7269\u8d44\u683c\u4e0a\u5e02\uff0c\u800c\u6709\u90e8\u5206\u836f\u7269\u5219\u662f\u4ee5\u9002\u5e94\u75c7\u62d3\u5c55\u7b49\u65b9\u5f0f\u83b7\u5f97\u7f55\u89c1\u75c5\u836f\u7269\u8d44\u683c\u3002\u56fe2\u662fFDA\u516c\u544a1983\u5e74\u4ee5\u6765\u7f55\u89c1\u75c5\u836f\u7269\u83b7\u51c6\u53d6\u5f97\u4e0a\u5e02\u8bb8\u53ef\u7684\u7edf\u8ba1\u7ed3\u679c\uff0c\u6839\u636eFDA\u7684\u5206\u6790\uff0c2017\u5e74\u5171\u670977\u4e2a\u7f55\u89c1\u75c5\u836f\u7269\u83b7\u6279\u4e0a\u5e02\uff0c\u4e0a\u5e02\u6210\u529f\u7387\u8fbe100%\uff0c\u6db5\u76d6\u80bf\u7624(58%)\u3001\u5176\u4ed6(10%)\u53ca\u4ee3\u8c22\u75be\u75c5(7%)\u3001\u795e\u7ecf\u75be\u75c5(7%)\u7b49\u4e3b\u8981\u6cbb\u7597\u9886\u57df\u3002\u7136\u800c\uff0c\u5373\u4f7f\u5728\u9ad8\u83b7\u51c6\u7387\u7684\u60c5\u52bf\u4e4b\u4e0b\uff0c\u4ecd\u670995%\u7684\u7f55\u89c1\u75c5\u65e0\u836f\u53ef\u6cbb[2]\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537925064.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u56fe2:1983\u5e74\u4ee5\u6765FDA\u6279\u51c6\u7f55\u89c1\u75c5\u836f\u7269\u7684\u7edf\u8ba1\u7ed3\u679c (\u8d44\u6599\u6765\u6e90: Insights into Rare Disease Drug Approval 2017, FDA)<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;padding-right: 6px;vertical-align: top;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-color: rgb(166, 91, 203);background-image: none;color: rgb(166, 91, 203);margin-right: 6px;border-bottom-width: 1px;border-bottom-style: solid;box-sizing: border-box;\">\n<p style=\"margin: 16px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);\">3. \u7f55\u89c1\u75c5\u836f\u7269\u7684\u4e34\u5e8a\u6210\u529f\u7387<\/span><\/p>\n<\/section>\n<section style=\"border-color: rgb(166, 91, 203);width: 0px;height: 22px;background-image: none;margin-top: -21px;margin-left: auto;border-left-width: 1px;border-left-style: solid;box-sizing: border-box;transform: rotate(30deg);-webkit-transform: rotate(30deg);-moz-transform: rotate(30deg);-o-transform: rotate(30deg);transform-origin: 0px 50% 0px;-webkit-transform-origin: 0px 50% 0px;-moz-transform-origin: 0px 50% 0px;-o-transform-origin: 0px 50% 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\">\u65e2\u7136\u5982FDA\u516c\u5e03\u7684\u57282017\u5e74\u7f55\u89c1\u75c5\u836f\u7269\u83b7\u6279\u7684\u6210\u529f\u7387\u662f100%\uff0c\u90a3\u4e48\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e0a\u7684\u6210\u529f\u7387\u5462? \u4ece2018\u5e74Wong et al.\u7684\u7814\u7a76\u6307\u51fa\uff0c\u4ece\u4e34\u5e8a\u4e00\u671f\u8d77\u7b97\u5230\u53d6\u5f97\u4e0a\u5e02\u8bb8\u53ef\uff0c\u7f55\u89c1\u75c5\u836f\u7269\u5e73\u5747\u7684\u6210\u529f\u7387\u662f6.2%\uff0c\u7565\u4f4e\u4e8e\u5176\u4ed6\u9002\u5e94\u75c7\u7528\u836f\u7684\u6210\u529f\u7387(6.9%)\u3002\u82e5\u628a\u80bf\u7624\u76f8\u5173\u7684\u9002\u5e94\u75c7\u6392\u9664\u540e\uff0c\u7f55\u89c1\u75c5\u836f\u7269(\u4e0d\u542b\u80bf\u7624\u7528\u836f)\u7684\u6210\u529f\u7387\u5219\u589e\u52a0\u81f313.6% (\u89c1\u56fe3)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537925065.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u56fe3:\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6210\u529f\u7387(\u6240\u6709\u9002\u5e94\u75c7\u3001\u9002\u7528\u7f55\u89c1\u75c5\u7684\u7f55\u89c1\u75c5\u836f\u7269\u4ee5\u53ca\u6392\u9664\u80bf\u7624\u7528\u836f\u7684\u7f55\u89c1\u75c5\u836f\u7269) (\u56fe\u8868\u4f9d\u636eWong et al., Biostatistics (2018) 00, 00, pp. 1\u201314\u5236\u4f5c)<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;padding-right: 6px;vertical-align: top;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-color: rgb(166, 91, 203);background-image: none;color: rgb(166, 91, 203);margin-right: 6px;border-bottom-width: 1px;border-bottom-style: solid;box-sizing: border-box;\">\n<p style=\"margin: 16px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);\">4. \u7f55\u89c1\u75c5\u836f\u7269\u5931\u8d25\u539f\u56e0\u5206\u6790<\/span><\/p>\n<\/section>\n<section style=\"border-color: rgb(166, 91, 203);width: 0px;height: 22px;background-image: none;margin-top: -21px;margin-left: auto;border-left-width: 1px;border-left-style: solid;box-sizing: border-box;transform: rotate(30deg);-webkit-transform: rotate(30deg);-moz-transform: rotate(30deg);-o-transform: rotate(30deg);transform-origin: 0px 50% 0px;-webkit-transform-origin: 0px 50% 0px;-moz-transform-origin: 0px 50% 0px;-o-transform-origin: 0px 50% 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\">\u56fe4\u63cf\u7ed8\u4e86\u5728\u6b27\u6d32\u7f55\u89c1\u75c5\u836f\u7269\u672a\u80fd\u53d6\u5f97\u4e0a\u5e02\u8bb8\u53ef\uff0c\u6216\u5728\u7814\u53d1\u8fc7\u7a0b\u4e2d\u88ab\u653e\u5f03\u5bfc\u81f3\u4e2d\u65ad\u7684\u539f\u56e0(\u56fe4\u5de6)\uff0c\u4ee5\u53ca\u8fdb\u4e00\u6b65\u5206\u6790\u56e0\u5b89\u5168\u6027\/\u6709\u6548\u6027\u5931\u8d25\u7684\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6cbb\u7597\u9886\u57df(\u56fe4\u53f3)\u3002\u4e0e\u5176\u4ed6\u5728\u7814\u53d1\u8fc7\u7a0b\u4e2d\u5931\u8d25\u7684\u836f\u7269\u76f8\u4f3c\uff0c\u7f55\u89c1\u75c5\u836f\u7269\u5931\u8d25\u7684\u4e3b\u8981\u539f\u56e0\u8fd8\u662f\u5728\u5b89\u5168\u6027\/\u6709\u6548\u6027(efficacy\/safety issue)\u3002\u5728\u672a\u80fd\u53d6\u5f97\u836f\u8bc1\u7684\u7f55\u89c1\u75c5\u836f\u7269\u5f53\u4e2d\uff0c\u524d\u4e09\u5927\u7684\u5931\u8d25\u539f\u56e0\u5206\u522b\u662f\uff1a\u5b89\u5168\u6027\/\u6709\u6548\u6027(52%)\u3001\u6570\u636e\u4e0d\u5145\u5206(insufficient data) (24%)\u4ee5\u53ca\u54c1\u8d28(quality issue)(14%)\uff1b50%\u7684\u5931\u8d25\u662f\u53d1\u751f\u5728\u4e34\u5e8a\u4e8c\u671f\u3002\u8fdb\u4e00\u6b65\u5206\u6790\u56e0\u5b89\u5168\u6027\/\u6709\u6548\u6027\u5931\u8d25\u7684\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6cbb\u7597\u9886\u57df\uff0c\u5206\u522b\u662f\u80bf\u7624\u3001 \u9057\u4f20\u6027\u4ee3\u8c22\u75be\u75c5(inborn errors of metabolism diseases)\u3001\u795e\u7ecf\u53ca\u7cbe\u795e\u75be\u75c5\u3001\u4ee5\u53ca\u5fc3\u8840\u7ba1\u53ca\u547c\u5438\u76f8\u5173\u75be\u75c5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537925065.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u56fe4\u5728\u6b27\u6d32\u7f55\u89c1\u75c5\u836f\u7269\u672a\u80fd\u53d6\u5f97\u4e0a\u5e02\u8bb8\u53ef\u6216\u5728\u7814\u53d1\u8fc7\u7a0b\u4e2d\u88ab\u653e\u5f03\u5bfc\u81f3\u4e2d\u65ad\u7684\u539f\u56e0(\u56fe4\u5de6)\uff0c\u4ee5\u53ca\u8fdb\u4e00\u6b65\u5206\u6790\u56e0\u5b89\u5168\u6027\/\u6709\u6548\u6027\u5931\u8d25\u7684\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6cbb\u7597\u9886\u57df(\u56fe4\u53f3) (\u8d44\u6599\u6765\u6e90: Source: BMJ Open 2017;7:e017358)&nbsp;<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;padding-right: 6px;vertical-align: top;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-color: rgb(166, 91, 203);background-image: none;color: rgb(166, 91, 203);margin-right: 6px;border-bottom-width: 1px;border-bottom-style: solid;box-sizing: border-box;\">\n<p style=\"margin: 16px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);\">5. \u7814\u53d1\u6210\u672c\u53ca\u7f55\u89c1\u75c5\u6cbb\u7597\u6210\u672c<\/span><\/p>\n<\/section>\n<section style=\"border-color: rgb(166, 91, 203);width: 0px;height: 22px;background-image: none;margin-top: -21px;margin-left: auto;border-left-width: 1px;border-left-style: solid;box-sizing: border-box;transform: rotate(30deg);-webkit-transform: rotate(30deg);-moz-transform: rotate(30deg);-o-transform: rotate(30deg);transform-origin: 0px 50% 0px;-webkit-transform-origin: 0px 50% 0px;-moz-transform-origin: 0px 50% 0px;-o-transform-origin: 0px 50% 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\">\u7f55\u89c1\u75c5\u836f\u7269\u4e0e\u975e\u7f55\u89c1\u75c5\u836f\u7269\u7684\u7814\u53d1\u6210\u672c\u5dee\u8ddd\u5728\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5982\u88682\u6240\u793a\uff0c\u7f55\u89c1\u75c5\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6210\u672c\u5728\u6263\u9664\u7a0e\u52a1\u62b5\u51cf\u524d\u662f\u975e\u7f55\u89c1\u75c5\u836f\u7269\u768450% [3]\uff1bLinda Martin\u7684\u7814\u7a76\u6307\u51fa\uff0c\u6267\u884c\u975e\u7f55\u89c1\u75c5\u836f\u7269\u5168\u7403\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6210\u672c\u4e2d\u4f4d\u6570\u7ea6\u662f3,340\u4e07\u7f8e\u5143[4]\uff0c\u56e0\u6b64\uff0c\u82e5\u8003\u8651\u4e34\u5e8a\u8bd5\u9a8c\u6210\u672c\u53ca\u7a0e\u52a1\u62b5\u51cf\uff0c\u7f55\u89c1\u75c5\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6210\u672c\u4e2d\u4f4d\u6570\u7ea6\u662f\u5728835\u4e07\u7f8e\u5143\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537925066.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;text-align: justify;background-image: none;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u88682:\u7814\u53d1\u7f55\u89c1\u75c5\u836f\u7269\u53ca\u975e\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6210\u672c\u6bd4\u8f83(\u672c\u8868\u57fa\u4e8e Sara Smith\u7684\u8bba\u6587\u53caNature Reviews Drug Discovery&nbsp;volume 16,&nbsp;pages 381\u2013382&nbsp;(2017)\u6574\u7406)<\/span><\/p>\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\">\u88683\u5217\u4e3e\u4e86\u90e8\u5206\u6cbb\u7597\u56e0\u57fa\u56e0\u5f02\u5e38\u5bfc\u81f4\u7684\u9057\u4f20\u6027\u7f55\u89c1\u75c5\u7684\u836f\u7269\u6cbb\u7597\u6210\u672c(\u4ee5\u6bcf\u4e2a\u75c5\u60a3\u6bcf\u5e74\u7684\u7528\u836f\u8d39\u7528\u4e3a\u8ba1\u7b97\u57fa\u7840)\uff0c\u5728\u7f8e\u56fd\u7684\u5e73\u5747\u6cbb\u7597\u6210\u672c\u662f147,308\u7f8e\u5143\uff0c\u800c\u975e\u7f55\u89c1\u75c5\u60a3\u8005\u7684\u7528\u836f\u6210\u672c\u662f30,708\u7f8e\u5143[5]\u3002\u867d\u7136\u7f55\u89c1\u75c5\u60a3\u8005\u7684\u6570\u91cf\u6709\u9650\uff0c\u82e5\u5c06\u90e8\u5206\u7f55\u89c1\u75c5\u7528\u836f\u7684\u9ad8\u836f\u4ef7\u7eb3\u5165\u8003\u91cf\uff0c\u8fd9\u4e9b\u836f\u7269\u7684\u4ecd\u80fd\u8fdb\u5165\u91cd\u78c5\u836f\u7269(blockbuster)\u540d\u5355(\u5e74\u9500\u552e\u989d\u8fbe\u621010\u4ebf\u7f8e\u5143)\uff0c\u4f8b\u5982\u7531Alexion Pharmaceuticals\u5f00\u53d1\u53ca\u9500\u552e\u7684Soliris\u00ae?<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537925067.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u88683:\u90e8\u5206\u56e0\u57fa\u56e0\u5f02\u5e38\u5bfc\u81f4\u7684\u9057\u4f20\u6027\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6cbb\u7597\u6210\u672c(\u4ee5\u6bcf\u4e2a\u75c5\u60a3\u6bcf\u5e74\u7684\u7528\u836f\u8d39\u7528\u4e3a\u8ba1\u7b97\u57fa\u7840)6<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;padding-right: 6px;vertical-align: top;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-color: rgb(166, 91, 203);background-image: none;color: rgb(166, 91, 203);margin-right: 6px;border-bottom-width: 1px;border-bottom-style: solid;box-sizing: border-box;\">\n<p style=\"margin: 16px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);\">6.\u7f55\u89c1\u75c5\u836f\u7269\u4e2d\u7684\u91cd\u78c5\u836f\u7269<\/span><\/p>\n<\/section>\n<section style=\"border-color: rgb(166, 91, 203);width: 0px;height: 22px;background-image: none;margin-top: -21px;margin-left: auto;border-left-width: 1px;border-left-style: solid;box-sizing: border-box;transform: rotate(30deg);-webkit-transform: rotate(30deg);-moz-transform: rotate(30deg);-o-transform: rotate(30deg);transform-origin: 0px 50% 0px;-webkit-transform-origin: 0px 50% 0px;-moz-transform-origin: 0px 50% 0px;-o-transform-origin: 0px 50% 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\">\u5168\u7403\u7f55\u89c1\u75c5\u836f\u7269\u7684\u5e74\u9500\u552e\u989d\u4f30\u8ba1\u5c06\u4ece2018\u5e74\u76841,380\u4ebf\u7f8e\u5143\u6210\u957f\u81f32024\u5e74\u76842,620\u4ebf\u7f8e\u5143(\u5e74\u590d\u5408\u6210\u957f\u7387\u4e3a11.38%)[7]\uff0c\u90e8\u5206\u7f55\u89c1\u75c5\u836f\u7269\u751a\u81f3\u53ef\u4ee5\u8fdb\u5165\u5e74\u9500\u552e\u989d\u8fbe10\u4ebf\u7f8e\u5143\u7684\u91cd\u78c5\u836f\u7269\u540d\u5355\uff0c\u4f8b\u5982\u7528\u4e8e\u6cbb\u7597\u514b\u9686\u6c0f\u75c7(Crohn\u2019s disease)\u7684Remicade\u00ae\u3001\u6cbb\u7597\u591a\u53d1\u6027\u786c\u5316\u75c7(multiple sclerosis)\u7684Copaxone\u00ae\u4ee5\u53ca\u7528\u4e8e\u6cbb\u7597\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624(non-Hodgkin\u2019s B-cell lymphoma)\u7684Rituxan\u00ae\uff0c\u5176\u4e2d\u6709\u90e8\u5206\u836f\u7269\u81ea\u9996\u6b21\u4e0a\u5e02\u8ddd\u4eca\u5df2\u8d85\u8fc720\u5e74\u4ecd\u80fd\u9ad8\u5c45\u91cd\u78c5\u836f\u7269\u4e4b\u4f4d\u3002\u5982\u88684\u6240\u793a\uff0c\u4e09\u79cd\u91cd\u78c5\u836f\u7269\u4e2d\u7684Remicade\u00ae\u548cRituxan\u00ae\u4e5f\u5728\u4e2d\u56fd\u4e0a\u5e02\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537925067.png\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u88684:\u91cd\u78c5\u7f55\u89c1\u75c5\u836f\u7269\u53ca\u5176\u76f8\u5e94\u7684\u9002\u5e94\u75c7\u3001\u9996\u6b21\u4e0a\u5e02\u65f6\u95f4\u30012017\u5e74\u7684\u9500\u552e\u989d\u4ee5\u53ca\u5728\u4e2d\u56fd\u4e0a\u5e02\u4e0e\u5426 (\u8d44\u6599\u6765\u6e90: Cortellis\u7ade\u4e89\u60c5\u62a5)<\/span><\/p>\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\">\u53e6\u5916\uff0c\u6839\u636eDrugs to Watch 2018\u7684\u7edf\u8ba1\uff0c\u7f57\u6c0f\u6700\u8fd1\u521a\u88abFDA\u6279\u51c6\u4e0a\u5e02\u3001\u7528\u4e8e\u6cbb\u7597A\u578b\u8840\u53cb\u75c5\u7684Hemlibra\u00ae \u57282019\u5e74\u5c06\u53ef\u8fbe\u5230\u91cd\u78c5\u7ea7\u522b\uff0c\u9884\u8ba1\u5e74\u9500\u552e\u989d\u8fbe14.57\u4ebf\u7f8e\u5143\u3002\u53e6\u5916\uff0c\u7528\u4e8e\u6cbb\u7597\u9057\u4f20\u6027\u5bb6\u65cf\u6027\u8f6c\u7532\u72b6\u817a\u7d20\u7c7b\u6dc0\u7c89\u86cb\u767d\u53d8\u6027(hereditary transthyretin-mediated amyloidosis, hATTR amyloidosis)\u7684Patisiran\uff0c\u662f\u9996\u4e2a(first-in-class) RNA\u5e72\u6270(RNAi)\u836f\u7269, \u521a\u4e8e2018\u5e748\u6708\u7531FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u4f30\u8ba1\u57282021\u5e74\u53ef\u8fbe\u91cd\u78c5\u7ea7\u522b\uff0c\u5e74\u9500\u552e\u989d11.04\u4ebf\u7f8e\u5143\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;padding-right: 6px;vertical-align: top;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-color: rgb(166, 91, 203);background-image: none;color: rgb(166, 91, 203);margin-right: 6px;border-bottom-width: 1px;border-bottom-style: solid;box-sizing: border-box;\">\n<p style=\"margin: 16px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);\">7. \u6b66\u7530\u5236\u836f\u5de8\u989d\u6536\u8d2d\u7f55\u89c1\u75c5\u836f\u7269\u9f99\u5934Shire<\/span><\/p>\n<\/section>\n<section style=\"border-color: rgb(166, 91, 203);width: 0px;height: 22px;background-image: none;margin-top: -21px;margin-left: auto;border-left-width: 1px;border-left-style: solid;box-sizing: border-box;transform: rotate(30deg);-webkit-transform: rotate(30deg);-moz-transform: rotate(30deg);-o-transform: rotate(30deg);transform-origin: 0px 50% 0px;-webkit-transform-origin: 0px 50% 0px;-moz-transform-origin: 0px 50% 0px;-o-transform-origin: 0px 50% 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\">\u57282018\u5e74\u521d\uff0c\u65e5\u672c\u7684\u6b66\u7530\u5236\u836f(Takeda)\u5f00\u4ef7623\u4ebf\u7f8e\u5143\u6536\u8d2d\u7f55\u89c1\u75c5\u836f\u7269\u9f99\u5934Shire\u3002Shire \u76ee\u524d\u5728\u7f55\u89c1\u75c5\u5171\u670933\u4e2a\u5df2\u4e0a\u5e02\u7684\u836f\u7269\u4e14\u5176\u4ea7\u54c1\u7ebf\u4e0a\u8fd8\u6709\u8d85\u8fc7100\u4e2a\u836f\u7269\u5728\u7814\u3002\u900f\u8fc7Cortellis\u7684\u865a\u62df\u5e76\u8d2d (virtual merger) \u5206\u6790\uff0c\u5728\u6b66\u7530\u5e76\u8d2dShire\u540e\u53ef\u4ee5\u5f3a\u5316\u4e34\u5e8a\u540e\u671f\u7684\u4ea7\u54c1\u7ebf\uff0c\u4e14\u5408\u5e76\u540e\u7684\u516c\u53f8\u5c06\u4faa\u8eab\u5168\u7403\u524d10\u5927\u836f\u5382\u4e4b\u5217\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<p style=\"text-align: left;background-image: none;text-indent: 2em;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\"><br  \/><\/p>\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"width: 100%;height: auto;vertical-align: middle;max-width: 100%;box-sizing: border-box;\"        src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537925068.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><span style=\"font-size: 12px;\">\u56fe5:\u6b66\u7530\u5e76\u8d2dShire\u540e\u7684\u4ea7\u54c1\u7ebf (\u8d44\u6599\u6765\u6e90: Cortellis\u7ade\u4e89\u60c5\u62a5)<\/span><\/section>\n<p><br  \/><\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;padding-right: 6px;vertical-align: top;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-color: rgb(166, 91, 203);background-image: none;color: rgb(166, 91, 203);margin-right: 6px;border-bottom-width: 1px;border-bottom-style: solid;box-sizing: border-box;\">\n<p style=\"margin: 16px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);\">8. \u7f55\u89c1\u75c5\u836f\u7269\u5728\u4e2d\u56fd\u7684\u53ef\u53ca\u6027<\/span><\/p>\n<\/section>\n<section style=\"border-color: rgb(166, 91, 203);width: 0px;height: 22px;background-image: none;margin-top: -21px;margin-left: auto;border-left-width: 1px;border-left-style: solid;box-sizing: border-box;transform: rotate(30deg);-webkit-transform: rotate(30deg);-moz-transform: rotate(30deg);-o-transform: rotate(30deg);transform-origin: 0px 50% 0px;-webkit-transform-origin: 0px 50% 0px;-moz-transform-origin: 0px 50% 0px;-o-transform-origin: 0px 50% 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;box-sizing: border-box;\">\u516c\u5e03\u7b2c\u4e00\u6279\u7f55\u89c1\u75c5\u540d\u5355\u5f00\u542f\u4e86\u5728\u4e2d\u56fd\u53d1\u5c55\u7f55\u89c1\u75c5\u7528\u836f\u7684\u7b2c\u4e00\u6247\u95e8\uff0c\u5728\u4e2d\u56fd\u53d6\u5f97\u5df2\u4e0a\u5e02\u7f55\u89c1\u75c5\u836f\u7269\u4e5f\u662f\u5728\u6b64\u9886\u57df\u53d1\u5c55\u7684\u91cd\u8981\u8bae\u9898\u3002\u6839\u636eGong et al.\u57282012\u5e74\u7684\u8c03\u67e5\u62a5\u544a[8]\u4e2d\u6307\u51fa\uff0c\u5728\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u6b27\u6d32\u5df2\u6838\u51c6\u7684408\u4e2a\u7f55\u89c1\u75c5\u836f\u7269\u4e2d\uff0c\u4ec5\u670940.4% (408\u4e2a\u7f55\u89c1\u75c5\u836f\u7269\u4e2d\u7684165\u4e2a) \u53ef\u4ee5\u5728\u8c03\u67e5\u4e2d\u768424\u95f4\u4e09\u7532\u533b\u9662\u8d2d\u5f97\u836f\u7269(\u89c1\u56fe6)\uff0c\u5176\u4e2d18.9%\u662f\u539f\u5382\u836f\uff0c45.8%\u662f\u5b66\u540d\u836f\uff0c\u53c8165\u4e2a\u4e2d\u7684120\u4e2a\u7f55\u89c1\u75c5\u836f\u7269\u53ef\u7531\u533b\u4fdd\u7ed9\u4ed8\uff1b\u5e73\u5747\u7684\u6cbb\u7597\u8d39\u7528\u4e3a4,843.5\u7f8e\u5143\uff0c\u76f8\u5f53\u4e8e\u4e2d\u7b49\u6536\u5165\u7684\u57ce\u5e02\u5c45\u6c11505.6\u5929\u7684\u6536\u5165\u3002\u6839\u636eGong\u7684\u8c03\u67e5\uff0c\u5927\u90e8\u5206\u53ef\u53d6\u5f97\u7684\u7f55\u89c1\u75c5\u836f\u7269\u4ecd\u662f\u8d85\u8fc7\u4e00\u822c\u6c11\u4f17\u7684\u8d1f\u8377\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537925068.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: justify;background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;white-space: normal;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u56fe6:\u7f8e\u56fd\u3001\u6b27\u6d32\u4ee5\u53ca\u65e5\u672c\u5df2\u6838\u51c6\u4e0a\u5e02\u7684\u7f55\u89c1\u75c5\u836f\u7269\u5728\u4e2d\u56fd\u7684\u53ef\u53ca\u6027 (\u672c\u56fe\u4f9d\u636eGong et al.\u7684\u7814\u7a76\u6574\u7406\uff0c\u53ef\u53ca\u6027\u4f9dGong et al. \u57282012\u5e74\u8c03\u67e5\u768424\u5bb6\u4e09\u7532\u533b\u9662\uff0c\u5728\u8c03\u67e5\u5f53\u65f6\u53ef\u8d2d\u5f97\u836f\u7269\u505a\u4e3a\u53ef\u53ca\u6027\u7684\u8ba1\u7b97\u57fa\u7840)<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u53d1\u751f\u5728\u4e2d\u56fd\u7684\u4e3b\u8981\u7f55\u89c1\u75c5\u5305\u62ec\u82ef\u916e\u5c3f\u75c7(phenylketonuria), (thalassemia)\u3001\u91cd\u578b\u6d77\u6d0b\u6027\u8d2b\u8840(thalassemia)\u3001\u6210\u9aa8\u4e0d\u5168\u75c7(osteogenesis imperfecta)\u3001\u9ad8\u8840\u6c28\u75c7(hyperammonemia)\u3001\u6709\u673a\u9178\u8840\u75c7(organic academia)\u4ee5\u53ca\u5a01\u5c14\u68ee\u6c0f\u75c7(Wilson&#8217;s disease)\u3001\u91cd\u75c7\u808c\u65e0\u529b(Myasthenia gravis) \u3001\u7ed3\u8282\u6027\u786c\u5316\u75c7 (tuberous sclerosis complex)\u3001\u767d\u5316\u75c5(albinism)\u7b49\u3002\u5176\u4ed6\u7684\u7f55\u89c1\u75c5\u5982\u8840\u53cb\u75c5(hemophilia)\u3001\u5e9e\u8d1d\u6c0f\u75c7(Pompe disease)\u548c\u56e0\u91a3\u8102\u8d28\u65e0\u6cd5\u5206\u89e3\u800c\u5806\u79ef\u5728\u4f53\u5185\u9020\u6210\u7684\u6cd5\u5e03\u745e\u6c0f\u75c7(Fabry disease)\uff0c\u5176\u4e2d\u5728\u4e2d\u56fd\u88ab\u8bca\u65ad\u51fa\u6cd5\u5e03\u745e\u6c0f\u75c7\u7684\u75c5\u60a3\u4e0d\u52305%\u3002\u53d1\u751f\u5728\u513f\u7ae5\u7684\u5219\u6709\u96c4\u6fc0\u7d20\u4e0d\u654f\u611f\u75c7(androgen insensitivity syndrome)\u3001\u808b\u819c\u80ba\u6bcd\u7ec6\u80de\u7624 (pleuropulmonary blastoma)\u3001\u6a2a\u7eb9\u808c\u8089\u7624(rhabdomyosarcoma\uff0c\u542b\u817a\u6ce1\u578b(alveolar)\u53ca\u80da\u80ce\u578b(embryonal)\u4e8c\u79cd\u5b50\u578b)\u3001Blau\u75c7\u5019\u7fa4 (Blau syndrome)\u3001Bardet-Biedl\u6c0f\u75c7\u5019\u7fa4(Bardet-Biedl Syndrome) \u4ee5\u53ca\u5148\u5929\u6027\u773c\u7403\u9707\u98a4(Infantile nystagmus syndrome)\u2026\u7b49\u513f\u79d1\u7f55\u89c1\u75c5\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u7f55\u89c1\u75c5\u6216\u6cd5\u5f8b\u5b9a\u4e49\u4e0a\u7684\u5b64\u513f\u75be\u75c5(orphan disease)\u7ea6\u5f71\u54cd\u4e2d\u56fd1600\u4e07\u4eba\uff0c\u4f30\u8ba1\u7684\u53d1\u75c5\u7387\u7ea6\u662f\u6bcf30-50\u4e07\u4eba\u7ea6\u67091\u540d\u75c5\u60a3\uff0c\u76ee\u524d\u5728\u4e2d\u56fd\u7684\u516c\u5e03\u7f55\u89c1\u75c5\u6570\u636e\u5c1a\u4e0d\u5b8c\u6574\uff0c\u4e5f\u6ca1\u6709\u8db3\u591f\u7684\u8d22\u52a1\u652f\u63f4\u7f55\u89c1\u75c5\u6cbb\u7597\uff0c\u5176\u4e2d\u4ec5\u6709\u90e8\u5206\u7684\u60a3\u8005\u80fd\u5f97\u5230\u6cbb\u7597\u3002\u76ee\u524d\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(NMPA)\u5c1a\u672a\u516c\u5e03\u5173\u4e8e\u7f55\u89c1\u75c5\u5728\u4e2d\u56fd\u7684\u7279\u522b\u6cd5\u53ca\u76f8\u5e94\u6761\u6b3e\uff0c\u4f7f\u5f97\u7f55\u89c1\u75c5\u60a3\u8005\u63a5\u53d7\u6cbb\u7597\u7684\u53ef\u53ca\u6027\u53d7\u5230\u5f71\u54cd\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u4e3b\u8981\u836f\u653f\u5e02\u573a\u7684\u76d1\u7ba1\u5355\u4f4d\u754c\u5b9a\u7f55\u89c1\u75c5\u4f1a\u7528\u4e24\u4e2a\u6807\u51c6\uff0c\u4e00\u4e2a\u662f\u7edd\u5bf9\u6570\u91cf\uff0c\u6bd4\u5982\u4f4e\u4e8e25\u4e07\u4eba\u53e3\uff0c\u5c31\u53ef\u4ee5\u5b9a\u4e49\u7f55\u89c1\u75c5\u3002\u4e00\u4e2a\u662f\u767e\u5206\u6bd4\uff0c\u6bd4\u5982\u4f4e\u4e8e\u4e07\u5206\u4e4b\u4e00\u7b49\uff0c\u505a\u4e3a\u7f55\u89c1\u75c5\u7684\u57fa\u7840\u5b9a\u4e49\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u7136\u800c\uff0c\u4e2d\u56fd\u6709\u774013\u4ebf\u7684\u4eba\u53e3\u57fa\u6570\uff0c\u8fd9\u4e8c\u4e2a\u6807\u51c6\uff0c\u65e0\u8bba\u7528\u54ea\u4e2a\uff0c\u5c06\u90fd\u662f\u4e00\u4e2a\u503c\u5f97\u5173\u6ce8\u7684\u6570\u5b57\uff0c\u8fd9\u4f1a\u5bf9\u652f\u4ed8\u90e8\u95e8(\u533b\u4fdd\u6216\u8005\u4fdd\u9669\u516c\u53f8)\u5e26\u6765\u5de8\u5927\u8d1f\u62c5\u3002\u7b2c\u4e00\u6279\u7f55\u89c1\u75c5\u76ee\u5f55\u7684121\u7f55\u89c1\u75c5\uff0c\u5b83\u65e2\u4e0d\u770b\u53d1\u75c5\u7387\u60a3\u75c5\u7387\uff0c\u4e5f\u4e0d\u770b\u7edd\u5bf9\u6570\u5b57\uff0c\u800c\u662f\u5efa\u8bbe\u6027\u7ed9\u51fa\u4e00\u4e2a\u76ee\u5f55\uff0c\u76f8\u4fe1\u662f\u5f81\u6c42\u4e86\u4e34\u5e8a\u533b\u5e08\u9700\u6c42\u610f\u89c1\u540e\u7ed9\u51fa\u7684\u3002\u8003\u91cf\u4e2d\u56fd\u81ea\u8eab\u7684\u9996\u8981\u9700\u6c42\uff0c\u7387\u5148\u63a8\u8fdb\u4e00\u6279\u7f55\u89c1\u75c5\u7684\u7814\u53d1\u548c\u6cbb\u7597\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;padding-right: 6px;vertical-align: top;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-color: rgb(166, 91, 203);background-image: none;color: rgb(166, 91, 203);margin-right: 6px;border-bottom-width: 1px;border-bottom-style: solid;box-sizing: border-box;\">\n<p><span style=\"color: rgb(122, 79, 214);font-size: 16px;\">9. \u975e\u80bf\u7624\u7f55\u89c1\u75c5\u7528\u836f\u5728\u4e2d\u56fd\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8d8b\u52bf<\/span><\/p>\n<\/section>\n<section style=\"border-color: rgb(166, 91, 203);width: 0px;height: 22px;background-image: none;margin-top: -21px;margin-left: auto;border-left-width: 1px;border-left-style: solid;box-sizing: border-box;transform: rotate(30deg);-webkit-transform: rotate(30deg);-moz-transform: rotate(30deg);-o-transform: rotate(30deg);transform-origin: 0px 50% 0px;-webkit-transform-origin: 0px 50% 0px;-moz-transform-origin: 0px 50% 0px;-o-transform-origin: 0px 50% 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: justify;background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;white-space: normal;box-sizing: border-box;\">\u89c2\u5bdf\u7b2c\u4e00\u6279\u7f55\u89c1\u75c5\u76ee\u5f55\u7684121\u4e2a\u7f55\u89c1\u75c5\u662f\u5c5e\u4e8e\u975e\u80bf\u7624\u7684\u7f55\u89c1\u75c5\uff0c\u8bf7\u53c2\u8003\u56fe7\u548c\u56fe8\uff0c\u8fdb\u4e00\u6b65\u5206\u6790\u8fd110\u5e74\u5728\u4e2d\u56fd\u7684\u4e34\u5e8a\u8bd5\u9a8c\u53ca\u975e\u80bf\u7624\u7f55\u89c1\u75c5\u7528\u836f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8d8b\u52bf\u3002\u5e73\u5747\u800c\u8a00\uff0c\u5728\u4e2d\u56fd\u7684\u6267\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c4.3%\u4e3a\u975e\u80bf\u7624\u7f55\u89c1\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6392\u9664\u4e34\u5e8a\u8bd5\u9a8c\u671f\u522b\u65e0\u6cd5\u786e\u5b9a\u7684\u6570\u91cf\u540e\uff0c\u5f53\u4e2d\u53c8\u4ee5\u4e34\u5e8a\u4e8c\u671f(\u901a\u5e38\u88ab\u89c6\u4e3a\u67a2\u7ebd\u8bd5\u9a8c(pivotal trials)\u7684\u6570\u91cf\u6700\u591a\uff0c\u7d27\u63a5\u7740\u7684\u662f\u4e34\u5e8a\u56db\u671f(\u4e0a\u5e02\u540e\u7684\u836f\u54c1\u76d1\u63a7\u8bd5\u9a8c)\u4ee5\u53ca\u4e34\u5e8a\u4e09\u671f\u7684\u8bd5\u9a8c\uff1b\u5728\u4e2d\u56fd\u6267\u884c\u7684\u591a\u4e3a\u540e\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f30\u8ba1\u548c\u4e0a\u5e02\u7b56\u7565\u6216\u4e0e\u76d1\u7ba1\u6cd5\u89c4\u8981\u6c42\u6709\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537925069.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: justify;background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;white-space: normal;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u56fe7:2008\u5e74\u52302018\u5e74\u6240\u6709\u9002\u5e94\u75c7\u53ca\u975e\u80bf\u7624\u7f55\u89c1\u75c5\u5728\u4e2d\u56fd\u6267\u884c\u4e34\u5e8a\u8bd5\u9a8c\u6570\u91cf\u6bd4\u8f83 (\u8d44\u6599\u6765\u6e90: Cortellis \u4e34\u5e8a\u60c5\u62a5\uff0c\u4f9d\u636eCortellis\u4e2d\u7f55\u89c1\u75c5\u7684\u7d22\u5f15\u6807\u7b7e(rare disease)\u6574\u7406\uff0c\u8d44\u6599\u83b7\u53d6\u65e5\u671f:2018\u5e747\u670830\u65e5)<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537925069.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: justify;background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;white-space: normal;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u56fe8:2008\u5e74\u52302018\u5e74\u6240\u6709\u9002\u5e94\u75c7\u53ca\u975e\u80bf\u7624\u7f55\u89c1\u75c5\u5728\u4e2d\u56fd\u6267\u884c\u4e34\u5e8a\u8bd5\u9a8c\u671f\u522b\u6bd4\u8f83 (\u8d44\u6599\u6765\u6e90: Cortellis \u4e34\u5e8a\u60c5\u62a5\uff0c\u4f9d\u636eCortellis\u4e2d\u7f55\u89c1\u75c5\u7684\u7d22\u5f15\u6807\u7b7e(rare disease)\u6574\u7406\uff0c\u8d44\u6599\u83b7\u53d6\u65e5\u671f:2018\u5e747\u670830\u65e5)<\/span><\/p>\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;white-space: normal;box-sizing: border-box;\">\u6574\u4f53\u800c\u8a00\uff0c2015\u5e74\u540e\u516c\u5f00\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u91cf\u6709\u660e\u663e\u6210\u957f\uff0c\u5982\u56fe9\u6240\u793a\uff0c\u7b2c\u4e00\u6279\u7f55\u89c1\u75c5\u540d\u5355\u7684121\u4e2a\u9002\u5e94\u75c7\u5728\u4e2d\u56fd\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e5f\u662f\u540e\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u91cf\u6700\u591a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537925070.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: justify;background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;white-space: normal;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u56fe9:2008\u5e74\u52302018\u5e74\u7b2c\u4e00\u6279\u7f55\u89c1\u75c5\u540d\u5355\u5728\u4e2d\u56fd\u7684\u4e34\u5e8a\u8bd5\u9a8c\u671f\u522b\u6bd4\u8f83 (\u8d44\u6599\u6765\u6e90: Cortellis \u4e34\u5e8a\u60c5\u62a5\uff0c\u4f9d\u636eCortellis\u4e2d\u9002\u5e94\u75c7\u540d\u79f0\u7684\u7d22\u5f15\u6807\u7b7e\u6574\u7406\uff0c\u8d44\u6599\u83b7\u53d6\u65e5\u671f:2018\u5e747\u670830\u65e5)<\/span><\/p>\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;white-space: normal;box-sizing: border-box;\">\u8fdb\u4e00\u6b65\u5206\u6790\u7b2c\u4e00\u6279\u7f55\u89c1\u75c5\u540d\u5355\u4e2d\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5982\u56fe10\u6240\u793a\uff0c\u6bd4\u4f8b\u6700\u9ad8\u7684\u662f\u795e\u7ecf\u75be\u75c5\u76f8\u5173\u7684\u7f55\u89c1\u75c5\uff0c\u536040%\uff0c\u5176\u6b21\u662f\u8840\u6db2\u76f8\u5173\u7684\u7f55\u89c1\u75c5(\u536029%)\uff0c\u5305\u62ec\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u7f3a\u4e4f(factor VIII deficiency)\u3001\u7b2c\u4e5d\u51dd\u8840\u56e0\u5b50\u7f3a\u4e4f (Factor IX deficiency)\u4ee5\u53ca\u8840\u53cb\u75c5\uff0c\u4e0e\u524d\u8ff0\u975e\u80bf\u7624\u7f55\u89c1\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u76f8\u4f3c\uff0c\u4e5f\u662f\u540e\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5c45\u591a\u6570\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;overflow: hidden;vertical-align: middle;display: inline-block;max-width: 100%;box-sizing: border-box;\">\n<p><img style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537925070.jpg\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/p>\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: justify;background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;white-space: normal;box-sizing: border-box;\"><span style=\"background-image: none;font-size: 12px;box-sizing: border-box;\">\u56fe10:2008\u52302018\u5e74\u7b2c\u4e00\u6279\u7f55\u89c1\u75c5\u540d\u5355\u4e2d\u7684121\u4e2a\u9002\u5e94\u75c7\u5728\u4e2d\u56fd\u7684\u4e34\u5e8a\u8bd5\u9a8c\u53ca\u671f\u522b (\u8d44\u6599\u6765\u6e90: Cortellis \u4e34\u5e8a\u60c5\u62a5\uff0c\u4f9d\u636eCortellis\u4e2d\u9002\u5e94\u75c7\u540d\u79f0\u7684\u7d22\u5f15\u6807\u7b7e\u6574\u7406\uff0c\u8d44\u6599\u83b7\u53d6\u65e5\u671f:2018\u5e747\u670830\u65e5)<\/span><\/p>\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;white-space: normal;box-sizing: border-box;\">\u4e2d\u56fd\u81ea2015\u5e74\u5f00\u59cb\u8fdb\u884c\u836f\u653f\u6539\u9769\uff0c\u76ee\u7684\u662f\u9f13\u52b1\u521b\u65b0\u53ca\u51cf\u5c11\u76d1\u7ba1\u6cd5\u89c4\u6240\u5e26\u6765\u7684\u8d1f\u62c5\uff0c\u65b0\u7684\u7f55\u89c1\u75c5\u836f\u7269\u53ef\u9002\u7528\u5305\u62ec\u4f18\u5148\u5ba1\u8bc4\u3001\u63a5\u53d7\u5883\u5916\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u4ee5\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u6539\u91c7\u5907\u6848\u5236\u7b49\u63aa\u65bd\uff0c\u5728\u5728\u53cd\u5e94\u51faNMPA\u5bf9\u521b\u65b0\u53ca\u52a0\u901f\u65b0\u836f\u4e0a\u5e02\u7684\u91cd\u89c6\u3002\u9884\u671f\u672a\u6765\u4e2d\u56fd\u6b63\u5f0f\u516c\u5e03\u7f55\u89c1\u75c5\u7684\u5b9a\u4e49\u540e\uff0c\u5bf9\u4e8e\u5728\u4e2d\u56fd\u53d1\u5c55\u7f55\u89c1\u75c5\u7684\u8fdc\u666f\u5c06\u4f1a\u66f4\u6e05\u6670\u3002<br style=\"background-image: none;box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;padding-right: 6px;vertical-align: top;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-color: rgb(166, 91, 203);background-image: none;color: rgb(166, 91, 203);margin-right: 6px;border-bottom-width: 1px;border-bottom-style: solid;box-sizing: border-box;\">\n<p style=\"margin: 16px 0px;padding: 0px;background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);\">10. \u7f55\u89c1\u75c5\u836f\u7269\u5728\u4e2d\u56fd\u7684\u613f\u666f<\/span><\/p>\n<\/section>\n<section style=\"border-color: rgb(166, 91, 203);width: 0px;height: 22px;background-image: none;margin-top: -21px;margin-left: auto;border-left-width: 1px;border-left-style: solid;box-sizing: border-box;transform: rotate(30deg);-webkit-transform: rotate(30deg);-moz-transform: rotate(30deg);-o-transform: rotate(30deg);transform-origin: 0px 50% 0px;-webkit-transform-origin: 0px 50% 0px;-moz-transform-origin: 0px 50% 0px;-o-transform-origin: 0px 50% 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: justify;background-image: none;line-height: 1.5;font-size: 14px;box-sizing: border-box;\">\n<p><span style=\"font-size: 14px;\">\u6839\u636eGong et al.\u7684\u7814\u7a76\uff0c\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\u6838\u51c6\u4e0a\u5e02\u7684\u7f55\u89c1\u75c5\u836f\u7269\u4e2d\uff0c\u5206\u522b\u4ec5\u670937.8%\u300124.6%\u548c52.4%\u80fd\u5728\u4e2d\u56fd\u7684\u4e09\u7532\u533b\u9662\u8d2d\u836f\u3002\u76f8\u8f83\u4e8e\u4e0a\u8ff0\u56fd\u5bb6\uff0c\u4e2d\u56fd\u5c1a\u672a\u516c\u5e03\u4f9d\u636e\u4eba\u53e3\u6216\u60a3\u75c5\u7387\u800c\u5b9a\u7684\u7f55\u89c1\u75c5\u7684\u5b98\u65b9\u5b9a\u4e49\uff0c\u4e5f\u8fd8\u6ca1\u516c\u5e03\u9488\u5bf9\u7f55\u89c1\u75c5\u4e0a\u5e02\u7684\u7279\u522b\u6cd5\u6216\u4f18\u60e0\u3002NMPA\u53ef\u4f9d\u7533\u8bf7\u4eba\u7684\u8bf7\u6c42\u8c41\u514d\u4e34\u5e8a\u8bd5\u9a8c\u6216\u51cf\u5c11\u53d7\u8bd5\u8005\u4eba\u6570\uff1b\u5728\u5176\u4ed6\u56fd\u5bb6\u5df2\u6838\u51c6\u4e0a\u5e02\u7684\u7f55\u89c1\u75c5\u836f\u7269\uff0cNMPA\u53ef\u80fd\u8003\u8651\u6709\u6761\u4ef6\u7684\u6279\u51c6\u4e0a\u5e02\uff0c\u5e76\u8981\u6c42\u7533\u8bf7\u4eba\u5728\u4e0a\u5e02\u540e\u8865\u5145\u8bd5\u9a8c\u6570\u636e\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u5c31\u73b0\u6709\u7684\u7f55\u89c1\u75c5\u540d\u5355\u6765\u770b\uff0c\u8eab\u4e3a\u5168\u7403\u7b2c\u4e8c\u5927\u533b\u836f\u5e02\u573a\u7684\u4e2d\u56fd\uff0c\u76ee\u6807\u662f\u52a0\u901f\u7f55\u89c1\u75c5\u7684\u8bca\u65ad\u53ca\u65b0\u836f\u4e0a\u5e02\uff1b\u7f55\u89c1\u75c5\u540d\u5355\u7684\u516c\u5e03\u5bf9\u4e8e\u540e\u7eed\u7684\u653f\u7b56\u65b9\u5411\u63d0\u4f9b\u533b\u7597\u7167\u62a4\u3001\u8d22\u52a1\u652f\u6301\u7684\u57fa\u7840\u3002\u4e2d\u56fd\u653f\u5e9c\u4e5f\u91cd\u89c6\u5efa\u7acb\u975e\u76c8\u5229\u7684\u7f55\u89c1\u75c5\u7814\u7a76\u673a\u6784\uff0c\u4f8b\u5982 \u4e2d\u56fd\u7f55\u89c1\u75c5\u53d1\u5c55\u4e2d\u5fc3(Chinese Organization for Rare Disorders, CORD) \u6210\u7acb\u4e8e2013\u5e74\uff0c\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u7f55\u89c1\u75c5\u9886\u57df\u7684\u975e\u8425\u5229\u7ec4\u7ec7\u3002\u7f55\u89c1\u75c5\u5728\u4e2d\u56fd\u7684\u53d1\u5c55\u53ef\u4ee5\u9884\u671f\u7684\u662f\u82e5\u7531\u56fd\u5bb6\u8ba1\u5212\u4fdd\u8bc1\u8986\u76d6\u660e\u786e\u7684\u7f55\u89c1\u75c5\uff0c\u5c06\u63a8\u52a8\u4e2d\u56fd\u7f55\u89c1\u75c5\u60a3\u8005\u7684\u533b\u7597\u4fdd\u969c\u7167\u987e\uff0c\u5bf9\u4e8e\u5df2\u5728\u5176\u4ed6\u56fd\u5bb6\u4e0a\u5e02\u7684\u7f55\u89c1\u75c5\u836f\u7269\uff0c NMPA\u53ef\u80fd\u4ee5\u7279\u522b\u6cd5\u89c4\u8303\u5176\u4e0a\u5e02\u53ca\u9500\u552e\uff0c\u4f7f\u5f97\u75c5\u60a3\u80fd\u5f97\u5230\u59a5\u5584\u6cbb\u7597\u53ca\u51cf\u5c11\u76d1\u7ba1\u5197\u4f59\u53ca\u7ecf\u6d4e\u4e0a\u7684\u8d1f\u62c5\u3002\u5176\u4ed6\u7684\u5173\u952e\u63aa\u65bd\u53ef\u80fd\u8fd8\u5305\u62ec\uff1a\u6bd4\u7167\u5176\u4ed6\u836f\u653f\u5e02\u573a\u5141\u8bb8\u7f55\u89c1\u75c5\u4ee5\u5feb\u901f\u901a\u9053\u7684\u4e0a\u5e02\u8def\u5f84\u3001\u514d\u9664\u5927\u89c4\u6a21\u4e34\u5e8a\u8bd5\u9a8c\u3001\u5bf9\u7f55\u89c1\u75c5\u836f\u7269\u7684\u7279\u522b\u8bb8\u53ef\u4ee5\u53ca\u914d\u5408\u5efa\u7acb\u75c5\u60a3\u7f51\u7edc\u548c\u6cbb\u7597\u8d39\u7528\u62a5\u9500\u7b49\u65b9\u5f0f\u3002 \u4e0a\u8ff0\u79cd\u79cd\u5c06\u4f7f\u4e2d\u56fd\u5728\u7f55\u89c1\u75c5\u7684\u533b\u7597\u7167\u62a4\u548c\u793e\u4f1a\u8d1f\u62c5\u4e0a\uff0c\u4f4d\u4e8e\u4e00\u4e2a\u6709\u5229\u4f4d\u7f6e\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\" >\n<section style=\"text-align: center;background-image: none;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"background-image: none;padding-right: 6px;vertical-align: top;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-color: rgb(166, 91, 203);background-image: none;color: rgb(166, 91, 203);margin-right: 6px;border-bottom-width: 1px;border-bottom-style: solid;box-sizing: border-box;\">\n<p><strong><span style=\"font-size: 16px;\">\u53c2\u8003\u8d44\u6599:<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" >\n<section>\n<section>\n<p><span style=\"font-size: 12px;\">1. GlobalGenes.org<\/span><\/p>\n<p><span style=\"font-size: 12px;\">2. GlobalGenes.org<\/span><\/p>\n<p><span style=\"font-size: 12px;\">3. Sara H D Smith, Trinity College, Orphan Drug Development: Incentives Under the Orphan Drug Act (2016)<\/span><\/p>\n<p><span style=\"font-size: 12px;\">4. Nature Reviews Drug Discovery volume 16, pages 381\u2013382 (2017)<\/span><\/p>\n<p><span style=\"font-size: 12px;\">5. Drug Discovery Today. 2018 Jan;23 (1):187-195)<\/span><\/p>\n<p><span style=\"font-size: 12px;\">6. Drug Discovery Today. 2018 Jan;23 (1):187-195)<\/span><\/p>\n<p><span style=\"font-size: 12px;\">7. Evaluate Pharma, Orphan Drug report (2018))<\/span><\/p>\n<p><span style=\"font-size: 12px;\">8. Gong et al. Orphanet Journal of Rare Diseases (2016) 11:20<\/span><\/p>\n<hr  \/>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(104, 23, 255);padding: 10px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 14px;box-sizing: border-box;\">\n<p style=\"text-align: center;box-sizing: border-box;\"><span style=\"color: rgb(104, 23, 255);\">\u624b\u673a\u7aef\u8bf7\u957f\u6309\u4e0b\u65b9\u4e8c\u7ef4\u7801\u767b\u5f55\uff08\u6ce8\u518c\uff09\u89c2\u770b\u76f8\u5173\u7814\u8ba8\u4f1a\u89c6\u9891\u56de\u653e<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;width: 40%;box-sizing: border-box;\"><img style=\"vertical-align: middle;width: 214px;box-sizing: border-box;height: 214px;\"          src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537925071.png\" alt=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\" title=\"\u7f55\u89c1\u75c5\u836f\u7269\u7684\u6311\u6218\u4e0e\u673a\u4f1a\u66a8\u5bf9\u4e2d\u56fd\u836f\u4f01\u7684\u542f\u793a\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 14px;box-sizing: border-box;\">\n<p style=\"text-align: center;box-sizing: border-box;\"><span style=\"color: rgb(104, 23, 255);box-sizing: border-box;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;box-sizing: border-box;\"><span style=\"color: rgb(104, 23, 255);box-sizing: border-box;font-size: 14px;\">PC\u7aef\u8bf7\u5c06\u6b64\u94fe\u63a5\u590d\u5236\u81f3\u6d4f\u89c8\u5668\u89c2\u770b\u56de\u653e\uff1a<\/span><\/p>\n<p style=\"text-align: center;box-sizing: border-box;\"><span style=\"box-sizing: border-box;font-size: 14px;\"><strong style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;color: rgb(104, 23, 255);box-sizing: border-box;\">http:\/\/uao.so\/spw46244<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;box-sizing: border-box;\"><span style=\"box-sizing: border-box;font-size: 14px;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(104, 23, 255);box-sizing: border-box;\"><br  \/><\/span><\/strong><\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u79d1\u777f\u552f\u5b89\u5bf9\u672c\u6587\u7684\u62a5\u544a\u5185\u5bb9\u4ee5\u53ca\u53ef\u80fd\u9644\u5e26\u7684\u5168\u90e8\u8d44\u6599\u62e5\u6709\u5168\u90e8\u77e5\u8bc6\u4ea7\u6743\uff0c\u5e76\u53d7\u6cd5\u5f8b\u4fdd\u62a4\uff0c\u5609\u5bbe\u89c2\u70b9\u4ec5\u4ee3\u8868\u4e2a\u4eba\u89c2\u70b9\u3002\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u7f51\u7edc\u8f6c\u8f7d\uff0c\u5546\u4e1a\u4f7f\u7528\u8bf7\u8054\u7cfb\uff1aYiLi1@Clarivate.com\u3002<\/span><\/p>\n<p style=\"text-align: center;box-sizing: border-box;\"><strong><span style=\"color: rgb(0, 82, 255);\">\u70b9\u51fb\u3010\u9605\u8bfb\u539f\u6587\u3011\u6ce8\u518c\u4e0b\u8f7d\u7814\u8ba8\u4f1a\u62a5\u544a\u5168\u6587<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<hr  \/>\n<p style=\"margin: 14px 0px;padding: 0px;background-image: none;white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><span style=\"color: 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":46019,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46018"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=46018"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46018\/revisions"}],"predecessor-version":[{"id":46035,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46018\/revisions\/46035"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/46019"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=46018"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=46018"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=46018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}