{"id":4612,"date":"2018-07-02T01:00:00","date_gmt":"2018-07-27T06:53:57","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e4%ba%9a%e9%a9%ac%e9%80%8a%e3%80%81%e9%98%bf%e9%87%8c%e8%bd%ae%e7%95%aa%e6%94%b6%e8%b4%ad%e8%8d%af%e5%ba%97%ef%bc%9b%e6%81%92%e7%91%9e%e5%b0%86%e5%bc%80%e5%b1%95%e5%8f%a3%e6%9c%8dglp-1%e4%b8%b4\/"},"modified":"2018-07-27T14:53:58","modified_gmt":"2018-07-27T06:53:58","slug":"%e4%ba%9a%e9%a9%ac%e9%80%8a%e3%80%81%e9%98%bf%e9%87%8c%e8%bd%ae%e7%95%aa%e6%94%b6%e8%b4%ad%e8%8d%af%e5%ba%97%ef%bc%9b%e6%81%92%e7%91%9e%e5%b0%86%e5%bc%80%e5%b1%95%e5%8f%a3%e6%9c%8dglp-1%e4%b8%b4","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/4612\/","title":{"rendered":"\u4e9a\u9a6c\u900a\u3001\u963f\u91cc\u8f6e\u756a\u6536\u8d2d\u836f\u5e97\uff1b\u6052\u745e\u5c06\u5f00\u5c55\u53e3\u670dGLP-1\u4e34\u5e8a\u8bd5\u9a8c……"},"content":{"rendered":"
\n

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<\/p>\n

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<\/span><\/p>\n

\u770b\u5230\u8fd9\u6761\u65b0\u95fb\uff0c\u6211\u60f3\u8d77\u6211\u4eec\u8457\u540d\u751f\u7269\u5b66\u5bb6\u674e\u6559\u6388\uff0c\u82e6\u5fc3\u94bb\u7814\u4e09\u5341\u5e74\uff0c\u6210\u529f\u57f9\u80b2\u51fa\u6297\u5bd2\u868a\u5b50\uff0c\u586b\u8865\u4e86\u51ac\u5929\u6ca1\u6709\u868a\u5b50\u7684\u7a7a\u767d\u3002\u5c0f\u4f19\u4f34\u513f\u4eec<\/span>\u6765\u4e86\u89e3\u4e00\u4e0b\u672c\u5468\u533b\u836f\u5708\u53d1\u751f\u7684\u65b0\u9c9c\u4e8b\u5427~<\/span><\/p>\n

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<\/p>\n

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1<\/span><\/p>\n<\/section>\n<\/section>\n

\u8bfa\u534e\u5ba3\u5e03\u5265\u79bb\u7231\u5c14\u5eb7<\/span><\/strong><\/span><\/strong><\/p>\n


<\/p>\n

6\u670829\u65e5\uff0c\u8bfa\u534e\u5236\u836f\u5ba3\u5e03\u62df\u5265\u79bb\u7231\u5c14\u5eb7\uff0c\u5e76\u5f00\u59cb\u56de\u8d2d\u4e0d\u8d85\u8fc750\u4ebf\u7f8e\u5143\u7684\u80a1\u7968\u3002\u4f5c\u4e3a\u8bfa\u534e\u82b1\u8d39520\u4ebf\u7f8e\u5143\u9ad8\u4ef7\u6536\u8d2d\u6765\u7684\u773c\u79d1\u4e1a\u52a1\u7ebf\uff0c\u8fd1\u4e24\u5e74\u9891\u4f20\u5173\u4e8e\u7231\u5c14\u5eb7\u5c06\u88ab\u5265\u79bb\u7684\u6d88\u606f\uff0c\u6b64\u6b21\u662f\u8bfa\u534e\u65b9\u9762\u9996\u6b21\u660e\u786e\u8868\u6001\u3002\u8bfa\u534e\u8d22\u62a5\u663e\u793a\uff0c\u81ea2014\u5e74\u4e09\u5b63\u5ea6\u4ee5\u6765\uff0c\u7231\u5c14\u5eb7\u7684\u4e1a\u7ee9\u6301\u7eed\u4e0b\u6ed1\uff0c2016\u5e74\u4e09\u5b63\u5ea6\uff0c\u7231\u5c14\u5eb7\u51c0\u9500\u552e\u989d\u4e3a16\u4ebf\u7f8e\u5143\u3002\u800c2011\u5e74\u8bfa\u534e\u5b8c\u6210100%\u6536\u8d2d\u7231\u5c14\u5eb7\u65f6\uff0c\u4e1a\u7ee9\u8fbe\u5230100\u4ebf\u7f8e\u5143<\/span><\/span><\/p>\n


<\/p>\n

\n
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<\/span><\/section>\n<\/section>\n

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<\/span><\/p>\n

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<\/p>\n

\n
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2<\/span><\/p>\n<\/section>\n<\/section>\n

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<\/span><\/strong><\/span><\/p>\n

6\u670827\u65e5\uff0c\u6052\u745e\u5ba3\u5e032\u6b3e1\u7c7b\u65b0\u836fSHR-2042 \u548c SHR0410\u83b7\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u3002\u5176\u4e2d\uff0cSHR-2042 \u4e3a\u53e3\u670d\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\uff08GLP-1\uff09\u7c7b\u4f3c\u7269\uff0c\u4e3b\u8981\u7528\u4e8e 2 \u578b\u7cd6\u5c3f\u75c5\u53ca\u80a5\u80d6\u75c7\u7684\u6cbb\u7597\u3002\u56fd\u5185\u5916\u6682\u65e0\u53e3\u670d GLP-1 \u7c7b\u4f3c\u7269\u83b7\u6279\u4e0a\u5e02\uff0c\u4ec5\u6709\u8bfa\u548c\u8bfa\u5fb7\u7814\u53d1\u7684\u53e3\u670d GLP-1 \u836f\u7269\u5904\u4e8e\u4e34\u5e8a\u7814\u7a76\u4e2d\u3002\u800cSHR0410 \u6ce8\u5c04\u6db2\u62df\u7528\u4e8e\u6025\u6027\u3001\u6162\u6027\u75bc\u75db\u548c\u7619\u75d2\u7684\u6cbb\u7597\u3002\u76ee\u524d\uff0c\u56fd\u5185\u5916\u6682\u65e0\u540c\u7c7b\u4ea7\u54c1\u4e0a\u5e02\uff0c\u4f46\u6709\u5728\u7814\u7684\u540c\u7c7b\u4ea7\u54c1\u5728\u7f8e\u56fd\u5904\u4e8e III \u671f\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\n
\n
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<\/p>\n
\u3000\u7f51\u53cb\u8bc4\u8bba<\/span><\/strong><\/span>\u3000<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n

\n
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<\/p>\n

@\u6570\u636e\u6d77\uff1a\u53e3\u670d\u591a\u80bd\u7c7b\u7cd6\u5c3f\u75c5\u836f\u7269\uff0c\u6052\u745e\u521b\u65b0\u8ddf\u7684\u592a\u7d27\u4e86\u3002<\/span><\/p>\n


<\/p>\n

@Stevevai1983: \u6052\u745e\u628a\u975e\u80f0\u5c9b\u7d20\u7c7b\u7684\u7cd6\u5c3f\u75c5\u4ea7\u54c1\u5168\u5e03\u5c40\u4e86\u3002 \u672a\u6765\u8fd9\u662f\u6052\u745e\u4e0b\u4e00\u4e2a\u91cd\u70b9\u79d1\u5ba4\u3002<\/span><\/p>\n


<\/span><\/p>\n

@\u6de1\u6c34\u7684\u9c7c\uff1a\u592a\u4e50\u89c2\u4e5f\u4e0d\u592a\u597d\uff0c\u6bd5\u7adf\u6211\u4eec\u8981\u6b63\u89c6\u6280\u672f\u548c\u6c34\u5e73\u7684\u5dee\u8ddd\uff0c\u4f46\u662f\u4e5f\u5f88\u4f69\u670d\u6052\u745e\u7684\u654f\u9510\u80fd\u529b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\n
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3<\/span><\/p>\n<\/section>\n<\/section>\n

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<\/span><\/p>\n

6\u670827\u65e5\uff0c\u836f\u660e\u5de8\u8bfa\u53ca\u5176\u5173\u8054\u516c\u53f8\u660e\u805a\u751f\u7269\u5ba3\u5e03\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u660e\u805a\u751f\u7269CAR-T\u4ea7\u54c1JWCAR029\u7684IND\u7533\u8bf7\uff0c\u6210\u4e3a\u9996\u5f20CD19\u9776\u70b9\u7684\u4e34\u5e8a\u6279\u4ef6\u3002\u8fd9\u4e5f\u662f\u7ee73\u670813\u65e5\uff0c\u5357\u4eac\u4f20\u5947\u83b7\u5f97\u9996\u4e2aCAR-T\u4e34\u5e8a\u6279\u4ef6\uff08\u9776\u70b9BCMA\uff09\u4ee5\u6765\uff0c\u7b2c\u4e8c\u5f20CAR-T\u4e34\u5e8a\u6279\u4ef6\u3002CDE\u5171\u53d7\u740623\u4e2aCAR-T\u7ec6\u80de\u4ea7\u54c1\u7684IND\u7533\u8bf7\uff0c\u5176\u4e2dCD19\u4e3a19\u4e2a\uff0c\u5360\u523083%\u3002\u8fd919\u4e2a\u7533\u8bf7\u6765\u81ea14\u5bb6\u516c\u53f8\uff0c\u5176\u4e2d\u4f18\u5361\u8fea\u548c\u6052\u6da6\u8fbe\u751f\u5404\u7533\u62a53\u4e2a\uff0c\u897f\u6bd4\u66fc\u7533\u62a52\u4e2a<\/span>\u3002<\/span><\/span><\/span><\/p>\n


<\/p>\n

\n
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<\/p>\n
\u3000\u7f51\u53cb\u8bc4\u8bba<\/span><\/strong><\/span>\u3000<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n

\n
\n
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<\/p>\n

@\u5f00\u5c01\u83dc\u7684\u85af\u6761\uff1a\u836f\u660e\u9760\u7740JUNO\u7684\u6280\u672f\uff0c\u62ff\u5230\u7b2c\u4e00\u5f20CD19\u7684\u4e34\u5e8a\u6279\u4ef6\u4e5f\u5728\u610f\u6599\u4e4b\u4e2d\uff0c\u4f46\u662f\u6700\u7ec8\u8fd8\u662f\u8981\u6570\u636e\u8bf4\u8bdd\u7684\u3002<\/span>
<\/p>\n


<\/span><\/p>\n

@\u4ed6\u5c71\u4e4b\u77f3\uff1a\u5206\u5b50\u51fa\u573a\uff0c\u5206\u6bcd\u5df2\u7ecf\u6709\u4e8c\u5341\u591a\u5bb6<\/span><\/p>\n


<\/span><\/p>\n

@\u5bbf\u5bbf\uff1a\u4e2d\u56fd\u7684CAR-T\u70ed\u5ea6\u592a\u9ad8\u4e86\uff0c\u5e94\u8be5\u8981\u6cfc\u70b9\u51b7\u6c34\u964d\u964d\u6e29<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\n
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4<\/span><\/p>\n<\/section>\n<\/section>\n

\u5e38\u5c71\u836f\u4e1a\u88ab\u7f5a60\u4e07\u5143<\/span><\/strong><\/span><\/strong><\/span><\/p>\n


<\/p>\n

6\u670824\u65e5\u665a\uff0c\u5e38\u5c71\u836f\u4e1a\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u6536\u5230\u6cb3\u5317\u8bc1\u76d1\u5c40\u884c\u653f\u5904\u7f5a\u4e8b\u5148\u544a\u77e5\u4e66\uff0c\u6cb3\u5317\u8bc1\u76d1\u5c40\u51b3\u5b9a\u5bf9\u5e38\u5c71\u836f\u4e1a\u7ed9\u4e88\u8b66\u544a\u5e76\u5904\u4ee5\u7f5a\u6b3e60\u4e07\u5143\uff0c\u5bf9\u516c\u53f8\u8463\u4e8b\u957f\u9ad8\u6811\u534e\u3001\u8463\u79d8\u5434\u5fd7\u5e73\u7ed9\u4e88\u8b66\u544a\u5e76\u5404\u590430\u4e07\u5143\u7f5a\u6b3e\u3002\u5904\u7f5a\u539f\u56e0\u7531\u4e8e5\u670815\u65e5\u5e38\u5c71\u836f\u4e1a\u66fe\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u636e\u7edf\u8ba1\u6570\u636e\u663e\u793a\uff0c\u201c\u56fd\u5185ED\u60a3\u8005\u4eba\u6570\u7ea61.4\u4ebf\u4eba\u201d\uff0c\u4f46\u6b64\u6570\u636e\u4e3b\u8981\u6765\u6e90\u4e8e\u5238\u5546\u7814\u62a5\uff0c\u516c\u53f8\u672a\u5bf9\u6570\u636e\u8fdb\u884c\u6838\u5b9e\uff0c\u5bf9\u6295\u8d44\u8005\u7684\u6295\u8d44\u884c\u4e3a\u4ea7\u751f\u8bef\u5bfc\uff0c\u4e14\u5bfc\u81f4\u516c\u53f8\u80a1\u7968\u4ea4\u6613\u51fa\u73b0\u5f02\u5e38\u6ce2\u52a8\u3002<\/span><\/span><\/p>\n

<\/span><\/p>\n

\n
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<\/p>\n
\u3000\u7f51\u53cb\u8bc4\u8bba<\/span><\/strong><\/span>\u3000<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n

\n
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<\/p>\n

@\u5976\u6cb9\uff1a\u4f5c\u4e3a\u4e00\u4e2a\u4e0a\u5e02\u516c\u53f8\uff0c\u8fd9\u4e48\u4e0d\u8d1f\u8d23\uff0c\u7f5a60\u4e07\u771f\u7684\u5c31\u591f\u4e86\u4e48\uff1f\u62c9\u5347\u80a1\u4ef7\uff0c\u5957\u73b0\u8d70\u4eba\uff0c\u8fd9\u6ce2\u64cd\u4f5c666<\/span>
<\/p>\n


<\/span><\/p>\n

@\u98ce\u53e3\uff1a\u600e\u4e48\u6ca1\u6709\u63d0\u51cf\u6301\u80a1\u7968\u7684\u4e8b\u60c5\uff0c\u51cf\u6301\u7a0b\u5e8f\u5408\u6cd5\uff0c\u62ab\u9732\u6709\u6240\u5938\u5927\uff0c\u4e24\u4ef6\u4e8b\u60c5\u5408\u5e76\u770b\u662f\u4e3a\u4e86\u9ad8\u4ef7\u51cf\u6301\u800c\u865a\u5047\u62ab\u9732\u3002\u7ed3\u679c\u662f\u5206\u5f00\u770b\uff0c\u51cf\u6301\u5408\u6cd5\u65e0\u7f6a\uff0c\u62ab\u9732\u4fe1\u606f\u4e0d\u660e\u7f5a\u6b3e60\u4e07<\/span><\/p>\n


<\/span><\/p>\n

@Alexnoir\uff1a\u8fd9\u4e2a\u5904\u7f5a\u544a\u8bc9\u5927\u5bb6\uff0c\u4e0d\u4ec5\u4e0dED\uff0c\u800c\u4e14\u5feb\u3001\u51c6\u3001\u72e0<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/span><\/p>\n


<\/p>\n

\n
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5<\/span><\/p>\n<\/section>\n<\/section>\n

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<\/span><\/strong><\/span><\/p>\n

6\u670829\u65e5\uff0c\u636e\u7f8e\u56fd\u8d22\u7ecf\u7f51\u7ad9CNBC\u62a5\u9053\uff0c\u4e9a\u9a6c\u900a\u5ba3\u5e03\u6536\u8d2d\u5c0f\u578b\u5728\u7ebf\u836f\u5e97PillPack\u3002\u5728\u8be5\u4ea4\u6613\u516c\u5e03\u540e\uff0c\u4e9a\u9a6c\u900a\u7684\u4e3b\u8981\u7ade\u4e89\u5bf9\u624b\u6c83\u5c14\u739b\u7684\u5e02\u503c\u5355\u65e5\u84b8\u53d1\u4e8630\u4ebf\u7f8e\u5143\u3002\u4e9a\u9a6c\u900a\u4ee5\u5927\u7ea610\u4ebf\u7f8e\u5143\u7684\u73b0\u91d1\u6536\u8d2d\u4e86PillPack\uff0c\u8fd9\u662f\u4e9a\u9a6c\u900a\u5728\u8fdb\u519b\u533b\u7597\u5065\u5eb7\u884c\u4e1a\u7684\u9053\u8def\u4e0a\uff0c\u8fc8\u51fa\u7684\u91cd\u8981\u4e00\u6b65\u3002PillPack\u662f\u4e00\u5bb6\u7f51\u4e0a\u836f\u5e97\uff0c\u4ed6\u4eec\u80fd\u4f9d\u7167\u5904\u65b9\uff0c\u5c06\u6bcf\u4e2a\u65f6\u95f4\u6bb5\u9700\u8981\u670d\u7528\u7684\u836f\u7269\u5355\u72ec\u5305\u88c5\uff0c\u76f4\u63a5\u5bc4\u5230\u60a3\u8005\u5bb6\u4e2d\uff0c\u65b9\u4fbf\u76f4\u63a5\u670d\u7528\u3002\u5e76\u4e14PillPack\u5728\u5168\u7f8e50\u4e2a\u5dde\u5747\u6709\u90ae\u5bc4\u836f\u7269\u7684\u8bb8\u53ef\u8bc1\uff0c\u8fd9\u5c06\u5229\u4e8e\u4e9a\u9a6c\u900a\u5728\u8fd9\u4e00\u9886\u57df\u7684\u5feb\u901f\u62d3\u5c55\u3002\u800c\u4f5c\u4e3a\u4e16\u754c\u4e0a\u89c4\u6a21\u6700\u5927\u7684\u7535\u5546\u4e4b\u4e00\uff0c\u4e9a\u9a6c\u900a\u7684\u7ecf\u9a8c\u4e0e\u8d44\u6e90\u4e5f\u5c06\u52a9\u529bPillPack\u7684\u53d1\u5c55\u3002<\/span><\/span><\/p>\n

<\/span><\/p>\n

\n
\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n
<\/p>\n
\u3000\u7f51\u53cb\u8bc4\u8bba<\/span><\/strong><\/span>\u3000<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n

\n
\n
\n


<\/span><\/p>\n

@\u4fac\u4f9d\uff1a\u8fd9\u544a\u8bc9\u6211\u4eec\uff0c\u7ebf\u4e0a\u836f\u5e97\u6700\u540e\u7684\u5f52\u5bbf\u90fd\u662f\u88ab\u5927\u7535\u5546\u6536\u8d2d\u3002<\/span><\/p>\n


<\/span><\/p>\n

@\u6768\u6811\u6797\uff1a\u8fd9\u5468\u963f\u91cc\u6536\u8d2d\u4e86\u836f\u5e97\uff0c\u4e9a\u9a6c\u900a\u4e5f\u6536\u8d2d\u4e86\u836f\u5e97\uff0c\u770b\u6765\u56fd\u5185\u5916\u5927\u4f6c\u601d\u8003\u95ee\u9898\u7684\u601d\u8def\u5f88\u76f8\u4f3c\u5462<\/span><\/p>\n


<\/span><\/p>\n

@\u9b54\u4e3b\uff1a\u4e00\u4e2a\u9884\u8a00\uff0c\u56fd\u5916\u7684\u7ebf\u4e0a\u533b\u836f\u96f6\u552e\u662f\u4e9a\u9a6c\u900a\u7684\u5929\u4e0b\uff0c\u4e2d\u56fd\u8fdf\u65e9\u662f\u963f\u91cc\u4eac\u4e1c\u7684\u5929\u4e0b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\n
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\u836f\u54c1\u7814\u53d1\u6ce8\u518c
<\/span><\/p>\n<\/section>\n<\/section>\n

\n


<\/p>\n

1.\u957f\u6548\u6d41\u611f\u836f\u7533\u8bf7\u4e0a\u5e02<\/span><\/strong><\/p>\n


<\/p>\n

Genentech6\u670827\u65e5\u5ba3\u5e03\uff0cFDA\u63a5\u53d7\u4e86\u516c\u53f8\u4e3a\u6297\u6d41\u611f\u65b0\u836fbaloxavir marboxil\u9012\u4ea4\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff0c\u5e76\u4e14\u6388\u4e88\u5176\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3002Baloxavir marboxil\u662f\u4e00\u79cd\u5177\u6709\u521b\u65b0\u6297\u6d41\u611f\u75c5\u6bd2\u673a\u5236\u7684\u521b\u65b0\u836f\u3001\u53ea\u9700\u53e3\u670d\u4e00\u6b21\u5c31\u80fd\u8d77\u6548\u7684\u6297\u6d41\u611f\u836f\u7269\u3002\u5b83\u5c06\u7528\u4e8e\u6cbb\u759712\u5c81\u4ee5\u4e0a\u7684\u65e0\u5e76\u53d1\u75c7\u7684\u6025\u6027\u6d41\u611f\u60a3\u8005\u3002<\/span><\/p>\n


<\/p>\n

2. olaparib\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u79ef\u6781<\/span><\/span><\/strong><\/span><\/p>\n


<\/p>\n

6\u670828\u65e5\uff0c\u963f\u65af\u5229\u5eb7\u4e0e\u9ed8\u6c99\u4e1c\u8054\u5408\u5ba3\u5e03Lynparza\uff08olaparib\uff09\u6cbb\u7597BRCA\u7a81\u53d8\u665a\u671f\u5375\u5de2\u764c\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8cSOLO-1\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u3002\u7ed3\u679c\u663e\u793a\uff0cLynparza\u4f5c\u4e3a\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u7684\u7597\u6548\u663e\u8457\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e5f\u5f97\u5230\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u7684\u663e\u8457\u6539\u5584\uff0c\u4e14\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4e0e\u5176\u4ed6\u4e34\u5e8a\u8bd5\u9a8c\u4e00\u81f4\u3002<\/span><\/p>\n


<\/span><\/p>\n

3.\u9ed1\u8272\u7d20\u7624\u83b7\u6279\u65b0\u7597\u6cd5<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

6\u670828\u65e5\uff0cArray BioPharma\u5ba3\u5e03\u7f8e\u56fdFDA\u6279\u51c6BRAFTOVI\u2122\u80f6\u56ca\u4e0eMEKTOVI\u00ae\u7247\u5242\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u5177\u6709BRAF V600E\u6216BRAF V600K\u7a81\u53d8\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002BRAFTOVI\u2122\u662f\u4e00\u79cd\u53e3\u670d\u5c0f\u5206\u5b50BRAF\u6fc0\u9176\u6291\u5236\u5242\uff0c\u800cMEKTOVI\u00ae\u662f\u4e00\u79cd\u53e3\u670d\u5c0f\u5206\u5b50MEK\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u9776\u5411MAPK\u4fe1\u53f7\u901a\u8def\uff08RAS-RAF-MEK-ERK\uff09\u4e2d\u7684\u5173\u952e\u9176\u3002<\/span><\/p>\n


<\/span><\/p>\n

<\/span><\/p>\n

4.\u793c\u6765AS\u65b0\u836f\u4e34\u5e8a\u7ed3\u679c\u79ef\u6781<\/span><\/strong><\/p>\n


<\/span><\/p>\n

6\u670829\u65e5\uff0c\u793c\u6765\u516c\u53f8\u5ba3\u5e03ixekizumab\u8fbe\u5230\u4e863\u671f\u4e34\u5e8a\u8bd5\u9a8cCOAST-W\u7684\u4e3b\u8981\u7ec8\u70b9\u548c\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u3002COAST-W\u8bc4\u4f30\u4e86ixekizumab\u6cbb\u7597\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u4e5f\u662f\u9996\u9879\u9488\u5bf9\u5728\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\uff08TNF\uff09\u6291\u5236\u5242\u7684\u6cbb\u7597\u4e0b\u7f13\u89e3\u4e0d\u8db3\u6216\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002ixekizumab\u662f\u4e00\u79cd\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u4e0e\u767d\u7ec6\u80de\u4ecb\u7d2017A\uff08IL-17A\uff09\u7ec6\u80de\u56e0\u5b50\u9009\u62e9\u6027\u7ed3\u5408\u5e76\u6291\u5236\u5176\u4e0eIL-17\u53d7\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/span><\/p>\n


<\/span><\/p>\n

5.\u53ef\u5f85\u56e0\u7c7b\u611f\u5192\u836f\u8bf4\u660e\u4e66\u518d\u4fee\u8ba2<\/span><\/strong><\/p>\n


<\/span><\/strong><\/p>\n

CDE\u53d1\u5e03\u5173\u4e8e\u5f81\u6c42\u201c\u542b\u53ef\u5f85\u56e0\u7c7b\u611f\u5192\u836f\u8bf4\u660e\u4e66\u4fee\u8ba2\u8981\u6c42\u201d\u610f\u89c1\u7684\u901a\u77e5\uff0c\u62df\u51b3\u5b9a\u5c06\u542b\u963f\u7247\u7c7b\u6210\u5206\u7684\u7528\u4e8e\u611f\u5192\u6216\u8fc7\u654f\u5f15\u8d77\u54b3\u55fd\u7684\u836f\u7269\u4ec5\u7528\u4e8e18\u5c81\u4ee5\u4e0a\u6210\u4eba\u3001\u7981\u7528\u4e8e18\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u3002\u8be5\u901a\u77e5\u5f81\u6c42\u610f\u89c1\u65f6\u95f4\u4e3a1\u4e2a\u6708\u3002\u53bb\u5e741\u6708\u4efd\u56fd\u5bb6\u98df\u836f\u76d1\u603b\u5c40\u5df2\u7ecf\u628a\u542b\u53ef\u5f85\u56e0\u836f\u54c1\u5c06\u660e\u786e\u6807\u6ce8\u7981\u7528\u4e8e12\u5c81\u4ee5\u4e0b\u513f\u7ae5\uff0c\u6b64\u6b21\u5f81\u6c42\u610f\u89c1\u53ef\u80fd\u5bfc\u81f4\u8be5\u7c7b\u836f\u7269\u7684\u9002\u7528\u4eba\u7fa4\u8fdb\u4e00\u6b65\u7f29\u5c0f\u3002<\/span><\/p>\n


<\/p>\n

\n
\n

\u6295\u8d44\u5e76\u8d2d
<\/span><\/p>\n<\/section>\n<\/section>\n


<\/p>\n

6.\u632f\u4e1c\u62df10\u4ebf\u5143\u51fa\u552e7\u5bb6\u5b50\u516c\u53f8<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

6\u670824\u65e5\uff0c\u632f\u4e1c\u5236\u836f\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u62df\u4ee510\u4ebf\u5143\u51fa\u552e7\u5bb6\u5b50\u516c\u53f8\uff0c\u5176\u4e2d\u5305\u62ec5\u5bb6\u533b\u836f\u8d38\u6613\u4f53\u7cfb\u516c\u53f8\u30012\u5bb6\u95f2\u7f6e\u7684\u751f\u4ea7\u5236\u9020\u4e1a\u8d44\u4ea7\u3002\u632f\u4e1c\u4e00\u6b21\u6027\u5904\u7f6e\u6389\u4e8f\u635f\u4ea7\u4e1a\u3001\u95f2\u7f6e\u8d44\u4ea7\u3001\u5904\u7f6e\u6548\u76ca\u4e0d\u7a81\u51fa\u7684\u7ba1\u7ebf\uff0c\u65e8\u5728\u63d0\u5347\u7ecf\u8425\u4e1a\u7ee9\u3001\u589e\u52a0\u8fd0\u8425\u8d44\u91d1\u3001\u96c6\u4e2d\u8d44\u6e90\u548c\u91ca\u653e\u9500\u552e\u56e2\u961f\u4f18\u52bf\u7b49\u30022017\u5e74\u632f\u4e1c\u7684\u8425\u6536\u4e3a37.31\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u957f13.66%\uff0c\u5f52\u5c5e\u51c0\u5229\u6da6\u7ea6\u4e3a3.02\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u957f48.49%\u3002<\/span><\/p>\n


<\/span><\/p>\n

7.<\/span><\/strong><\/span> \u963f\u91cc\u6536\u8d2d\u6f31\u7389\u5e73\u6c11\u5927\u836f\u623f<\/span><\/strong><\/span><\/p>\n


<\/p>\n

6\u670825\u65e5\u665a\uff0c\u963f\u91cc\u5065\u5eb7\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u5176\u9644\u5c5e\u516c\u53f8\u4e0e\u6f31\u7389\u5e73\u6c11\u5927\u836f\u623f\u8fde\u9501\u80a1\u4efd\u6709\u9650\u516c\u53f8\u5df2\u7ecf\u6b63\u5f0f\u7b7e\u8ba2\u589e\u8d44\u534f\u8bae\u3002\u6839\u636e\u534f\u8bae\uff0c\u963f\u91cc\u5065\u5eb7\u5c06\u5411\u6f31\u7389\u5e73\u6c11\u5927\u836f\u623f\u6ce8\u5165\u73b0\u91d1\u4eba\u6c11\u5e014.544\u4ebf\u5143\uff0c\u5176\u4e2d3408\u4e07\u5143\u7528\u4e8e\u589e\u52a0\u540e\u8005\u7684\u6ce8\u518c\u8d44\u672c\uff0c4.2032\u4ebf\u5143\u7528\u4e8e\u540e\u8005\u7684\u8d44\u672c\u50a8\u5907\u3002\u589e\u8d44\u534f\u8bae\u4ea4\u5272\u540e\uff0c\u963f\u91cc\u5065\u5eb7\u501f\u6b64\u5c06\u6301\u6709\u6f31\u7389\u5e73\u6c11\u5927\u836f\u623f9.34%\u7684\u80a1\u6743\u3002\u622a\u6b622017\u5e74\u5e95\uff0c\u6f31\u7389\u5e73\u6c11\u53ca\u5176\u8fd0\u8425\u9644\u5c5e\u516c\u53f8\u5728\u4e2d\u56fd\u7ecf\u8425\u8d851200\u5bb6\u836f\u623f\u30022016\u5e74\u5ea6\u53ca2017\u5e74\u5ea6\u5206\u522b\u53d6\u5f97\u7eaf\u52299455\u4e07\u5143\u53ca1.18\u4ebf\u5143\u3002<\/span><\/p>\n


<\/p>\n

8.Skyhawk Therapeutics\u83b7\u5f971\u4ebf\u7f8e\u5143\u79cd\u5b50\u8f6e\u878d\u8d44<\/span><\/strong><\/p>\n

 <\/p>\n

6\u670826\u65e5\uff0c\u7531Celgene\u9886\u6295\uff0cAlexandriaVenture Investments\u3001GreatPoint Ventures\u3001 ShangPharma Innovation \u548cAgent Capital\u5171\u540c\u53c2\u4e0e\uff0c\u5b8c\u6210\u4e86\u5bf9SkyhawkTherapeutics\u6570\u76ee\u4e3a1\u4ebf\u5143\u7684\u79cd\u5b50\u8f6e\u6295\u8d44\uff0c\u6295\u8d44\u5c06\u7528\u4e8e\u591a\u79cdRNA\u9776\u5411\u836f\u7269\u7684\u5f00\u53d1\u3002<\/span><\/p>\n

<\/span>
<\/p>\n

9.\u4e3d\u73e0\u5355\u6297\u83b7\u5f971.48\u4ebf\u7f8e\u5143\u589e\u8d44<\/span><\/strong><\/p>\n


<\/p>\n

<\/span><\/p>\n

6\u670823\u65e5\uff0c\u4e3d\u73e0\u533b\u836f\u96c6\u56e2\u80a1\u4efd\u6709\u9650\u516c\u53f8\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u4e3d\u73e0\u96c6\u56e2\u5883\u5916\u5168\u8d44\u9644\u5c5e\u516c\u53f8Livzon International Limited\u4e0e\u4e91\u950b\u57fa\u91d1\u65d7\u4e0bYF Pharmab Limited\u62df\u5171\u540c\u4ee5\u8d27\u5e01\u65b9\u5f0f\u5411Livzon Biologics Limited\u8fdb\u884c\u589e\u8d44\uff0c\u589e\u8d44\u6570\u76ee\u4e3a1.48\u4ebf\u7f8e\u5143\uff0c\u6765\u4fc3\u8fdb\u4e3d\u73e0\u96c6\u56e2\u751f\u7269\u836f\u4e1a\u52a1\u5728\u56fd\u5185\u53ca\u56fd\u9645\u5e02\u573a\u5f00\u53d1\u4e0e\u62d3\u5c55\u3002<\/span><\/p>\n


<\/p>\n

10.\u5e7f\u751f\u5802\u6536\u8d2d\u6c5f\u82cf\u4e2d\u5174<\/span><\/strong>
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6\u670827\u65e5\uff0c\u5e7f\u751f\u5802\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u4ee59693.75\u4e07\u5143\u6536\u8d2d\u6c5f\u82cf\u4e2d\u5174\u836f\u4e1a\u6709\u9650\u516c\u53f882.5%\u7684\u80a1\u6743\u3002\u4e2d\u5174\u836f\u4e1a\u662f\u4ee5\u751f\u4ea7\u5236\u5242\u548c\u539f\u6599\u836f\u4e3a\u4e3b\u7684\u73b0\u4ee3\u5316\u4f01\u4e1a\uff0c\u4e3b\u8981\u751f\u4ea7\u4fdd\u809d\u62a4\u809d\u7cfb\u5217\u4ea7\u54c1\uff0c\u662f\u56fd\u5185\u8f83\u5927\u7684\u6c34\u98de\u84df\u5236\u5242\u751f\u4ea7\u4f01\u4e1a\u4e4b\u4e00\uff0c\u6c34\u98de\u84df\u5bbe\u7c7b\u836f\u7269\u5c06\u6210\u4e3a\u5e7f\u751f\u5802\u5728\u809d\u810f\u5065\u5eb7\u9886\u57df\u7684\u53c8\u4e00\u4f18\u52bf\u4ea7\u54c1\u3002<\/span><\/p>\n


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11.GE\u533b\u7597\u5c06\u72ec\u7acb\u8fd0\u8425<\/span><\/strong>
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<\/span><\/strong><\/span><\/p>\n

14.\u57fa\u77f3\u4e0eAgios\u8fbe\u6210\u72ec\u5bb6\u5408\u4f5c<\/span><\/strong>
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15. \u6d88\u764c\u5e73\u88ab\u8981\u6c42\u6539\u540d<\/span><\/strong><\/span><\/p>\n


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<\/p>\n

16.\u6e56\u5317\u8981\u6c42\u63a2\u7d22\u5265\u79bb\u95e8\u8bca\u836f\u623f<\/span><\/strong><\/p>\n


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17.\u6d77\u6b63\u8f89\u745e\u6b63\u5f0f\u66f4\u540d<\/span><\/strong><\/p>\n


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<\/p>\n

\"\u4e9a\u9a6c\u900a\u3001\u963f\u91cc\u8f6e\u756a\u6536\u8d2d\u836f\u5e97\uff1b\u6052\u745e\u5c06\u5f00\u5c55\u53e3\u670dGLP-1\u4e34\u5e8a\u8bd5\u9a8c......\"<\/p>\n


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\n<\/section>\n


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\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u884c\u821fDrug <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8 \u770b\u5230\u8fd9\u6761\u65b0\u95fb\uff0c\u6211\u60f3\u8d77\u6211\u4eec\u8457\u540d\u751f\u7269\u5b66\u5bb6\u674e\u6559 […]<\/p>\n","protected":false},"author":1,"featured_media":4613,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4612"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=4612"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4612\/revisions"}],"predecessor-version":[{"id":4619,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4612\/revisions\/4619"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/4613"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=4612"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=4612"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=4612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}