{"id":46243,"date":"2018-09-21T01:00:00","date_gmt":"2018-09-26T01:26:20","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/142%e4%b8%aa%e5%8c%96%e8%8d%af%e6%92%a4%e5%b8%82%ef%bc%8c49%e4%b8%aa%e6%ba%90%e4%ba%8e%e5%ae%89%e5%85%a8%e6%80%a7%ef%bc%81\/"},"modified":"2018-09-26T09:26:24","modified_gmt":"2018-09-26T01:26:24","slug":"142%e4%b8%aa%e5%8c%96%e8%8d%af%e6%92%a4%e5%b8%82%ef%bc%8c49%e4%b8%aa%e6%ba%90%e4%ba%8e%e5%ae%89%e5%85%a8%e6%80%a7%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/46243\/","title":{"rendered":"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"__bg_gif\"     style=\"font-size: 16px;white-space: normal;color: rgb(62, 62, 62);line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible 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15px;\">\u7f57\u975e\u6614\u5e03\uff0cMerck\u516c\u53f8\u7814\u5236\u7684COX-2\u6291\u5236\u5242\uff1b1999\u5e745\u6708\u83b7FDA\u6279\u51c6\uff0c\u540c\u5e746\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u9aa8\u5173\u8282\u708e\u3001\u63a7\u5236\u6210\u4eba\u9510\u75db\u548c\u75db\u7ecf\u30022004\u5e749\u6708\uff0c\u56e0\u4e25\u91cd\u7684\u8840\u7ba1\u6bd2\u6027\u800c\u64a4\u5e02\uff0c\u671f\u95f4\uff0c\u5168\u7403\u670d\u7528\u8be5\u836f\u7684\u60a3\u8005\u8fbe8000\u4e07\u3002\u7f57\u975e\u6614\u5e03\u7684\u64a4\u5e02\u53ef\u4ee5\u8bf4\u201c\u5751\u201d\u4e86\u4e00\u6279\u60a3\u8005\uff0c\u5374\u6210\u5168\u4e86\u8f89\u745e\u516c\u53f8\u7684\u540c\u7c7b\u7ade\u54c1~\u585e\u6765\u6614\u5e03\uff08\u897f\u4e50\u8446\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 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15px;\">\u66f2\u683c\u5217\u916e\uff0c\u7b2c\u4e00\u4e09\u5171\u682a\u5f0f\u4f1a\u793e\u7814\u53d1\uff0c\u4e3a\u567b\u5511\u70f7\u4e8c\u916e\u7c7b\u6297\u7cd6\u5c3f\u75c5\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u80f0\u5c9b\u7d20\u6cbb\u7597\u6548\u679c\u672a\u8fbe\u9884\u671f\u76842\u578b\u7cd6\u5c3f\u75c5\uff1b1997\u5e741\u6708\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7531\u8f89\u745e\u5728\u7f8e\u56fd\u5e02\u573a\u9500\u552e\uff0c\u5546\u54c1\u540d\u4e3aRezulin\u00ae\u3002\u7531\u4e8e\u5177\u6709\u8f83\u9ad8\u7684\u6f5c\u5728\u809d\u6bd2\u526f\u4f5c\u7528\uff0c\u66f2\u683c\u5217\u916e\u6700\u65e9\u4e8e1997\u5e74\u5728\u82f1\u56fd\u5e02\u573a\u64a4\u5e02\uff0c\u540e\u4e8e2000\u5e74\u9000\u51fa\u7f8e\u56fd\u4e0e\u65e5\u672c\u5e02\u573a\uff0c\u5728\u6b27\u6d32\u5176\u4ed6\u56fd\u5bb6\u672a\u83b7\u5f97\u6279\u51c6\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u2606\u52a0\u66ff\u6c99\u661f~\u4ee3\u8c22\u7d0a\u4e71<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537925182.png\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<p style=\"text-align: center;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u52a0\u66ff\u6c99\u661f\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u5f00\u53d1\uff0c\u662f\u4e00\u79cd\u6c1f\u55b9\u8bfa\u916e\u7c7b\u6297\u83cc\u836f\uff0c\u5176\u4f5c\u7528\u4e0e\u73af\u4e19\u6c99\u661f\u7c7b\u4f3c\uff1b1999\u5e74\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u5728\u7f8e\u56fd\u63a8\u51fa\u52a0\u66ff\u6c99\u661f\uff0c2004\u5e74\u4f4d\u5217\u7f8e\u56fd\u5e02\u573a\u6297\u611f\u67d3\u836f\u7269\u53e3\u670d\u5242\u7ec4\u7b2c12\u4f4d\u3002\u4f462000\u5e741\u67081\u65e5~2005\u5e746\u670830\u65e5\uff0cFDA\u5171\u6536\u5230388\u4f8b\u52a0\u66ff\u6c99\u661f\u81f4\u8840\u7cd6\u7d0a\u4e71\u4e0d\u826f\u53cd\u5e94\u62a5\u544a\uff0c\u5176\u4e2d159\u4f8b\u5df2\u4f4f\u9662\u63a5\u53d7\u6cbb\u7597\uff0c20\u4f8b\u6b7b\u4ea1\u3002\u7531\u4e8e\u6536\u5230\u8bb8\u591a\u6709\u5173\u52a0\u66ff\u6c99\u661f\u53ef\u81f4\u4e25\u91cd\u6216\u81f4\u6b7b\u6027\u4f4e\u8840\u7cd6\u6216\u9ad8\u8840\u7cd6\u4e0d\u826f\u53cd\u5e94\u62a5\u544a\uff0c2006\u5e745\u670815\u65e5\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\u5ba3\u5e03\u505c\u6b62\u751f\u4ea7\u52a0\u66ff\u6c99\u661f\u7247\u5242\u548c\u6ce8\u5c04\u5242\uff0c\u5e76\u4ece\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u64a4\u5e02\u3002\u5176\u9000\u5e02\uff0c\u7ed9\u6c99\u661f\u7c7b\u6297\u83cc\u836f\u8499\u4e0a\u4e86\u4e00\u5c42\u539a\u539a\u7684\u9634\u973e\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u2606\u8212\u6d1b\u82ac~\u80be\u6bd2\u6027<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537925182.png\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<p style=\"text-align: center;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8212\u6d1b\u82ac\uff0c\u4e00\u79cdNSAID\uff0c1%\u8212\u6d1b\u82ac\u53ef\u4f5c\u4e3a\u6ef4\u773c\u6db2\u7528\u4e8e\u6291\u5236\u773c\u90e8\u624b\u672f\u65f6\u53ef\u80fd\u53d1\u751f\u7684\u77b3\u5b54\u7f29\u5c0f\uff0c\u5b83\u66fe\u7ecf\u53e3\u670d\u7528\u4e8e\u8f7b\u4e2d\u5ea6\u75bc\u75db\u3001\u9aa8\u5173\u8282\u708e\u548c\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3002\u4f46\u5728\u4e0d\u826f\u80be\u53cd\u5e94\u7684\u62a5\u9053\u540e\uff0c\u5176\u53e3\u670d\u5242\u578b\u7684\u9500\u552e\u5728\u4e16\u754c\u8303\u56f4\u5185\u88ab\u505c\u6b62\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u2606\u8d1d\u62c9\u5730\u5c14~\u836f\u7269\u76f8\u4e92\u4f5c\u7528<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537925182.png\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<p style=\"text-align: center;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8d1d\u62c9\u5730\u5c14\uff0c\u7528\u4e8e\u6cbb\u7597\u9ad8\u8840\u538b\uff0c1997\u5e74\u7531\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u4f46\u7531\u4e8e\u5b83\u4e0e\u5176\u4ed6\u836f\u7269\u4e00\u8d77\u670d\u7528\u65f6\u5b58\u5728\u6f5c\u5728\u7684\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u5176\u4e2d\u4e00\u4e9b\u53ef\u80fd\u4f1a\u81f4\u547d\uff0c\u6240\u4ee5\u8be5\u836f\u57281998\u5e74\u88ab\u64a4\u56de\u30022010\u5e748\u6708\uff0cTau Therapeutics\uff08\u73b0\u4e3aCavion\uff09\u4e0e\u7f57\u6c0f\u7b7e\u8ba2\u4e86\u5173\u4e8e\u8be5\u836f\u7684\u8f6c\u8ba9\u534f\u8bae\uff0cCavion\u5bf9\u8be5\u836f\u91cd\u65b0\u8fdb\u884c\u5f00\u53d1\uff0c\u4e34\u5e8a\u7528\u4e8e\u6cbb\u7597\u6210\u80f6\u8d28\u7ec6\u80de\u7624\u4e0e\u795e\u7ecf\u80f6\u8d28\u7624\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u2606\u897f\u7acb\u4f10\u4ed6\u6c40~\u6a2a\u7eb9\u808c\u6eb6\u89e3<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537925182.png\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<p style=\"text-align: center;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u897f\u7acb\u4f10\u4ed6\u6c40\u94a0\uff0c\u5fb7\u56fdBayer\u516c\u53f8\u5f00\u53d1\uff0c\u4ed6\u6c40\u7c7b\u964d\u8102\u836f\uff0c1997\u5e74FDA\u6279\u51c6\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c1999\u5e74\u8fdb\u4eba\u4e2d\u56fd\u5e02\u573a\u3002\u81ea\u4e0a\u5e02\u4ee5\u6765\uff0c\u5168\u4e16\u754c\u670980\u591a\u4e2a\u56fd\u5bb6600\u591a\u4e07\u60a3\u8005\u4f7f\u7528\u6b64\u836f(\u4ec5\u7f8e\u56fd\u5c31\u6709\u7ea670\u4e07\u7684\u670d\u7528\u8005)\uff0c\u4f46\u968f\u7740\u836f\u7269\u7684\u5e7f\u6cdb\u4f7f\u7528\uff0c\u5168\u7403\u5171\u6536\u523052\u4f8b\u56e0\u670d\u7528\u8be5\u836f\u800c\u4ea7\u751f\u6a2a\u7eb9\u808c\u6eb6\u89e3\u6240\u81f4\u7684\u6b7b\u4ea1\u62a5\u544a(\u4ec5\u7f8e\u56fdFDA\u5c31\u6536\u5230\u4e8631\u4f8b)\uff0c\u636eFDA\u62a5\u9053\uff0c\u62dc\u65af\u4ead\u5f15\u8d77\u81f4\u6b7b\u6027\u6a2a\u7eb9\u808c\u6eb6\u89e3\u75c7\u663e\u8457\u591a\u4e8e\u5df2\u4e0a\u5e02\u7684\u5176\u4ed6\u540c\u7c7b\u4ea7\u54c1\uff0c\u56e0\u6b64\uff0cBayer\u516c\u53f8\u4e8e2001\u5e748\u6708\u5c06\u62dc\u65af\u4ead\u64a4\u79bb\u5168\u7403\u5e02\u573a\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section style=\"width: 100%;padding-top: 10px;padding-bottom: 10px;box-sizing: border-box;\" >\n<section style=\"display:inline-block;\">\n<section style=\"display:flex;justify-content: flex-end;display: -webkit-flex;-webkit-justify-content: flex-end;\">\n<section style=\"color: rgb(0, 128, 255);padding-bottom: 6px;padding-right: 10px;font-weight: bold;box-sizing: border-box;\" class=\"135brush\" ><span style=\"font-family: Helvetica, Arial, sans-serif;font-size: 15px;\"><strong style=\"font-size: 16px;text-align: justify;white-space: normal;\">2.\u7b80\u8ff0\u56e0\u5b89\u5168\u6027\u95ee\u9898\u800c\u64a4\u5e02\u768449\u4e2a\u5316\u5b66\u836f\u7269<\/strong><\/span><\/section>\n<section style=\"margin-top:12px;\">\n<section style=\"width: 20px;height: 20px;border-radius: 100%;background: rgba(128, 255, 0, 0.9);opacity: 0.5;float: right;color: rgb(255, 255, 255);box-sizing: border-box;\"   ><\/section>\n<section style=\"width: 15px;height: 15px;border-radius: 100%;background: rgb(0, 128, 255);opacity: 0.5;float: right;margin-top: 3px;margin-right: -10px;color: rgb(255, 255, 255);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"border-bottom: 1px dashed rgb(204, 204, 204);margin-top: -8px;margin-right: 30px;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u901a\u8fc7\u67e5\u8be2\u6570\u636e\u5e93\u3001\u6587\u732e\uff0c\u5982\u4e0a\u6240\u8ff0\uff0c\u7b14\u8005\u5171\u67e5\u5230<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>\u8fd1142\u4e2a<\/strong><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5316\u5b66\u836f\u7269\u5df2\u64a4\u5e02\uff0c\u64a4\u5e02\u539f\u56e0\u4e3b\u8981\u96c6\u4e2d\u4e8e\u5b89\u5168\u6027\u95ee\u9898\u53ca\u540c\u7c7b\u7ade\u54c1\u7ade\u4e89\uff1b\u5176\u4e2d\uff0c\u56e0\u5b89\u5168\u6027\u95ee\u9898\u64a4\u5e02\u836f\u7269\u5171<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>49\u4e2a<\/strong><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\uff0c\u8be6\u7ec6\u60c5\u51b5\u89c1\u4e0b\u8868\uff08\u9644\u5e26\u7ed3\u6784\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 16px;color: rgb(0, 0, 0);background-color: rgb(255, 218, 81);\"><strong>49\u4e2a\u56e0\u5b89\u5168\u6027\u800c\u64a4\u5e02\u7684\u5316\u836f<\/strong><\/span><br  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537925182.jpg\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537925183.jpg\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537925183.jpg\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537925183.jpg\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537925184.jpg\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537925184.jpg\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537925184.png\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section style=\"width: 100%;padding-top: 10px;padding-bottom: 10px;box-sizing: border-box;\" >\n<section style=\"display:inline-block;\">\n<section style=\"display:flex;justify-content: flex-end;display: -webkit-flex;-webkit-justify-content: flex-end;\">\n<section style=\"color: rgb(0, 128, 255);padding-bottom: 6px;padding-right: 10px;font-weight: bold;box-sizing: border-box;\" class=\"135brush\" ><span style=\"font-family: Helvetica, Arial, sans-serif;\">\u5c0f\u7ed3<\/span><\/section>\n<section style=\"margin-top:12px;\">\n<section style=\"width: 20px;height: 20px;border-radius: 100%;background: rgba(128, 255, 0, 0.9);opacity: 0.5;float: right;color: rgb(255, 255, 255);box-sizing: border-box;\"   ><\/section>\n<section style=\"width: 15px;height: 15px;border-radius: 100%;background: rgb(0, 128, 255);opacity: 0.5;float: right;margin-top: 3px;margin-right: -10px;color: rgb(255, 255, 255);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"border-bottom: 1px dashed rgb(204, 204, 204);margin-top: -8px;margin-right: 30px;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u9996\u5148\uff0c\u8981\u5f3a\u8c03\u7684\u662f\uff0c\u836f\u7269\u56e0\u5b89\u5168\u6027\u95ee\u9898\u800c\u4e0d\u5f97\u4e0d\u64a4\u5e02\uff0c\u5927\u591a\u65e0\u53ef\u5948\u4f55\uff0c\u6bd5\u7adfIII\u671f\u4e34\u5e8a\u7684\u6837\u672c\u91cf\u4e0e\u4e0a\u5e02\u540e\u7684\u6837\u672c\u91cf\u6bd4\u8d77\u6765\uff0c\u8fd8\u662f\u8fdc\u8fdc\u4e0d\u591f\uff0c\u4e14\u5f53\u524d\u7684\u6280\u672f\u624b\u6bb5\u5f80\u5f80\u8fd8\u4e0d\u8db3\u4ee5\u5f62\u6210\u66f4\u597d\u7684\u9884\u89c1\u6027\u3002\u5176\u6b21\uff0c49\u4e2a\u56e0\u5b89\u5168\u6027\u95ee\u9898\u800c\u64a4\u5e02\u836f\u7269\u5f53\u4e2d\uff0c<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>\u5fc3\u8840\u7ba1\u6bd2\u6027\u3001\u809d\u6bd2\u6027\u3001\u6210\u763e\u6027\u7b49\u95ee\u9898\u76f8\u5bf9\u8f83\u4e3a\u7a81\u51fa<\/strong><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\uff0c\u503c\u5f97\u836f\u7269\u7814\u53d1\u4eba\u5458\u5728\u672a\u6765\u7684\u836f\u7269\u5f00\u53d1\u8fc7\u7a0b\u4e2d\uff0c\u591a\u591a\u52a0\u4ee5\u5173\u6ce8\u3002\u518d\u6b21\uff0c\u7b14\u8005\u66fe\u8bd5\u56fe\u67e5\u8be2\u4e00\u4e9b\u54c1\u79cd\u66f4\u4e3a\u6df1\u5165\u5177\u4f53\u7684\u56e0\u5b89\u5168\u6027\u95ee\u9898\u800c\u64a4\u5e02\u7684\u539f\u56e0\uff0c\u800c\u7ed3\u679c\u591a\u4e3a\u63a8\u6d4b\uff0c\u5e76\u672a\u62a5\u9053\u53d1\u751f\u5b89\u5168\u6027\u95ee\u9898\u7684\u771f\u6b63\u673a\u5236\u6240\u5728\uff0c\u6545\u5018\u82e5\u836f\u5ba1\u90e8\u95e8\u8981\u6c42\u539f\u7814\u4f01\u4e1a\u5bf9\u64a4\u5e02\u836f\u7269\u7ed9\u51fa\u8be6\u7ec6\u7684\u6bd2\u6027\u7814\u7a76\u62a5\u544a\uff0c\u4e5f\u8bb8\u5c31\u66f4\u597d\u4e86\u3002<\/span><\/p>\n<p><span style=\"font-size: 15px;\">&nbsp;<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">\u53c2\u8003\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">1. Post-marketingdrug withdrawals: Pharmacovigilance success, regulatory problems.<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">2. Safety dataand withdrawal of hepatotoxic drugs.<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">3. Drugwithdrawals and the utilization of therapeutic substitutes: The case of Vioxx.<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">4. Withdrawalof anti-epileptic drugs: A review.<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">5. https:\/\/data.pharmacodia.com<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">6. CNKI<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;list-style-type: none;padding-inline-start: 0px;margin-block-start: 0px;margin-block-end: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 2px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537925184.jpeg\" alt=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\" title=\"142\u4e2a\u5316\u836f\u64a4\u5e02\uff0c49\u4e2a\u6e90\u4e8e\u201c\u5b89\u5168\u6027\u201d\uff01\"><\/p>\n<p style=\"white-space: normal;list-style-type: none;padding-inline-start: 0px;margin-block-start: 0px;margin-block-end: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 2px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5f80\u671f\u7cbe\u5f69<\/span><\/strong><\/p>\n<p style=\"white-space: normal;list-style-type: none;padding-inline-start: 0px;margin-block-start: 0px;margin-block-end: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 2px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;text-decoration: underline;color: rgb(120, 172, 254);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231167&amp;idx=1&amp;sn=28235cb4fd7bb283cf83af16cc7d3a42&amp;chksm=84be7824b3c9f132888169756d6229bda5f6942392c2d5adf0678a7bd053afa3b48bf35d379d&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(120, 172, 254);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e00\u81f4\u6027\u8bc4\u4ef7\u76843\u5bb6\u4e0e3\u5e74<\/a><\/span><\/p>\n<p style=\"white-space: normal;list-style-type: none;padding-inline-start: 0px;margin-block-start: 0px;margin-block-end: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 2px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652230701&amp;idx=1&amp;sn=ea702ea398a915207c0901323d96697a&amp;chksm=84be79f6b3c9f0e08013a45f74ccb18f77b2470d83a0b6a500591ffc2970fa796b24166bd325&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(120, 172, 254);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6c47\u805a\u5357\u836f\u7275\u7ebf\u642d\u6865 &nbsp;\u6821\u4f01\u643a\u624b\u5171\u540c\u63a2\u7d22\u4eba\u624d\u57f9\u517b\u65b0\u6a21\u5f0f\u4e00\u4e00\u9996\u5c4aCRA\u4eba\u624d\u57f9\u8bad\u73ed\u7eaa\u5b9e<\/a><\/p>\n<p style=\"white-space: normal;list-style-type: none;padding-inline-start: 0px;margin-block-start: 0px;margin-block-end: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 2px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231162&amp;idx=1&amp;sn=7b4cf87e991464cf2205db0c1293d26f&amp;chksm=84be7821b3c9f13739102fa0302f2743f323e9c92658af76d99cd548cb37cba12cd3c96b1193&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u540c\u5fc3\u7b51\u68a6\u2014\u2014\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u4e0a\u6d77\u6821\u53cb\u4f1a\u5e74\u4f1a\u4fa7\u8bb0<\/a><\/p>\n<p style=\"white-space: normal;list-style-type: none;padding-inline-start: 0px;margin-block-start: 0px;margin-block-end: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 2px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(120, 172, 254);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231395&amp;idx=1&amp;sn=82b2e145bdd8711af2f6c8893456540f&amp;chksm=84be7b38b3c9f22e034b9d2e1eac88905f0d7157281960b676a50e597de212fc8af967145eb2&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3010\u6848\u4f8b\u8bf4\u3011\u6570\u636e&amp;\u4e34\u5e8a\u4e4b\u771f\u5b9e\u4e16\u754c\u7814\u7a76<\/a><\/span><\/p>\n<p style=\"white-space: normal;list-style-type: none;padding-inline-start: 0px;margin-block-start: 0px;margin-block-end: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 2px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231751&amp;idx=1&amp;sn=dce65e202747c083d07e8f2a0f1afea1&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6211\u4eec\u7684\u6bd5\u4e1a\u5b63<\/a><\/p>\n<p style=\"white-space: normal;list-style-type: none;padding-inline-start: 0px;margin-block-start: 0px;margin-block-end: 0px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: justify;background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 2px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\"><br  \/><\/span><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u9898\u8bb0 \u836f\u7269\u64a4\u5e02\u4e09\u5927\u539f\u56e0\uff0c\u5b89\u5168\u6027\u95ee\u9898\u3001\u540c\u7c7b\u4ea7\u54c1\u66ff\u4ee3\u3001\u76d1\u7ba1\u653f\u7b56\u53d8\u52a8\uff1b\u5176\u4e2d\uff0c\u5b89\u5168\u6027\u95ee\u9898\u662f\u836f\u7269\u64a4\u5e02\u6700\u4e3a\u5f3a\u5236\u4e14\u65e0\u53ef\u5948\u4f55\u7684 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":46244,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46243"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=46243"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46243\/revisions"}],"predecessor-version":[{"id":46260,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46243\/revisions\/46260"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/46244"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=46243"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=46243"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=46243"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}