{"id":46293,"date":"2018-09-20T01:00:00","date_gmt":"2018-09-26T01:26:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e5%a6%82%e4%bd%95%e6%9d%a5%e7%a1%ae%e5%ae%9a%e7%be%8e%e5%9b%bd%e5%8f%82%e6%af%94%e5%88%b6%e5%89%82%e7%94%9f%e4%ba%a7%e5%95%86-%e6%a0%bc%e5%8d%8e%e6%ad%a2%e7%bc%93%e9%87%8a%e7%89%87-glucophage-xr\/"},"modified":"2018-09-26T09:26:49","modified_gmt":"2018-09-26T01:26:49","slug":"%e5%a6%82%e4%bd%95%e6%9d%a5%e7%a1%ae%e5%ae%9a%e7%be%8e%e5%9b%bd%e5%8f%82%e6%af%94%e5%88%b6%e5%89%82%e7%94%9f%e4%ba%a7%e5%95%86-%e6%a0%bc%e5%8d%8e%e6%ad%a2%e7%bc%93%e9%87%8a%e7%89%87-glucophage-xr","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/46293\/","title":{"rendered":"\u5982\u4f55\u6765\u786e\u5b9a\u7f8e\u56fd\u53c2\u6bd4\u5236\u5242\u751f\u4ea7\u5546–\u683c\u534e\u6b62\u7f13\u91ca\u7247 (GLUCOPHAGE XR) \uff1f"},"content":{"rendered":"
\n

\"\u5982\u4f55\u6765\u786e\u5b9a\u7f8e\u56fd\u53c2\u6bd4\u5236\u5242\u751f\u4ea7\u5546--\u683c\u534e\u6b62\u7f13\u91ca\u7247<\/p>\n

\"\u5982\u4f55\u6765\u786e\u5b9a\u7f8e\u56fd\u53c2\u6bd4\u5236\u5242\u751f\u4ea7\u5546--\u683c\u534e\u6b62\u7f13\u91ca\u7247<\/p>\n

\u672c\u5fae\u4fe1\u516c\u4f17\u53f7\u6536\u5230\u5f88\u591a\u5173\u4e8e\u683c\u534e\u6b62\u7f13\u91ca\u7247GLUCOPHAGE XR\u53c2\u6bd4\u5236\u5242\u4e00\u6b21\u6027\u8fdb\u53e3\u7684\u54a8\u8be2\uff0c\u9700\u8981\u5e2e\u52a9\u786e\u8ba4\u751f\u4ea7\u5546\u548c\u6301\u8bc1\u5546\uff0c\u5728\u8fd9\u91cc\u7edf\u4e00\u7b54\u590d\u3002\u5982\u679c\u6709\u4ec0\u4e48\u95ee\u9898\uff0c\u6b22\u8fce\u4e92\u52a8\u6c9f\u901a\u3002<\/p>\n


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\u9996\u5148\uff0c\u8ba9\u6211\u4eec\u6765\u786e\u8ba4\u6301\u8bc1\u5546\u3002\u5f88\u591a\u53c2\u6bd4\u5236\u5242\u7684\u7f51\u53cb\uff0c\u4e0e\u6211\u4eec\u6c9f\u901a\u4ea4\u6d41\uff0c\u8bf4\u6a58\u76ae\u4e66\u4e0a\u9762\u5c31\u6709\u7684\u3002\u8ba9\u6211\u4eec\u6765\u770b\u4e00\u4e0b\u6a58\u76ae\u4e66\u4e0a\u9762\u7684\u4fe1\u606f\u3002\u3000<\/p>\n


<\/p>\n

\"\u5982\u4f55\u6765\u786e\u5b9a\u7f8e\u56fd\u53c2\u6bd4\u5236\u5242\u751f\u4ea7\u5546--\u683c\u534e\u6b62\u7f13\u91ca\u7247<\/p>\n

\u6a58\u76ae\u4e66\u4e0a\u9762\u7684APPLICANT HOLDER\uff0c\u662f BRISTOL MYERS SQUIBB CO\u3002\u8fd9\u4e2a\u662f\u6301\u8bc1\u5546\uff0c\u4f46\u662f\uff0c\u6ca1\u6709\u5730\u5740\u7684\u4fe1\u606f\u3002\u56fd\u5916\u5927\u516c\u53f8\u836f\u5382\uff0c\u56e0\u4e3a\u6709\u5f88\u591a\u4e0d\u540c\u7684\u5206\u90e8\uff0c\u5b50\u516c\u53f8\uff0c\u6301\u8bc1\u5546\u7684\u5730\u5740\uff0c\u6709\u65f6\u5019\u4f1a\u5f88\u5934\u75bc\u3002\u6709\u5f88\u591a\u4f01\u4e1a\u7ed9\u6211\u4eec\u53cd\u9988\uff0c\u6301\u8bc1\u5546\u5730\u5740\u7a0d\u5fae\u9519\u4e00\u70b9\uff0c\u56fd\u5185\u76d1\u7ba1\u90e8\u95e8\uff0c\u5c31\u8981\u6c42\u91cd\u65b0\u529e\u7406\u8fdb\u53e3\u6279\u4ef6\u3002 <\/p>\n


<\/p>\n

\u6301\u8bc1\u5546\u7684\u5730\u5740\u5982\u4f55\u6765\u786e\u5b9a\uff1f<\/p>\n

\u672c\u516c\u4f17\u53f7\u5728\uff12\uff10\uff11\uff18\u5e74\uff12\u6708\uff11\uff10\u65e5\u53d1\u8868\u7684\u6587\u7ae0\u201c\u5982\u4f55\u786e\u8ba4\u7f8e\u56fd\u53c2\u6bd4\u5236\u5242\u7684\u6301\u8bc1\u5546\u548c\u751f\u4ea7\u5546\uff1f\u201d\u3000\u4e2d\u63d0\u5230\uff0c\u65b0\u836f\u8bc1\u4e66\u6279\u51c6\u7ed9\u54ea\u4e2a\u516c\u53f8\uff0c\u90a3\u5c31\u662f\u6301\u8bc1\u5546\u3002\u65b0\u836f\u7533\u8bf7\u6279\u51c6\u4fe1\u4e0a\u9762\u5199\u7684\u662f\uff0c\u548c\u8bf4\u660e\u4e66\u4e0a\u5199\u7684 DISTRIBUTED BY \u90fd\u662f\u540c\u4e00\u4e2a\u5730\u5740\u7684\u516c\u53f8\uff0c\u5c31\u662f “<\/span>Bristol-Myers Squibb Company Princeton, NJ 08543 USA”.  \u6301\u8bc1\u5546\u7684\u5730\u5740\uff0c\u57fa\u672c\u4e0a\u5c31\u662f\u8fd9\u4e2a\u4e86\u3002\u5f20\u535a\u58eb\u5efa\u8bae\uff0c\u56fd\u5185\u516c\u53f8\u7533\u8bf7\u8fdb\u53e3\u6279\u4ef6\u7684\u65f6\u5019\uff0c\u5982\u679c\u6ca1\u6709\u628a\u63e1\uff0c\u6301\u8bc1\u5546\u7684\u5177\u4f53\u8857\u9053\u5730\u5740\uff0c\u4e0d\u8981\u5199\u3002 \u56e0\u4e3a\u6301\u8bc1\u5546\uff0c\u57fa\u672c\u4e0a\u662f\u516c\u53f8\u603b\u90e8\u4e4b\u7c7b\u7684\u5730\u5740\uff0c\u5728\u7f8e\u56fd\uff0c\u5f88\u591a\u5927\u7684\u836f\u4f01\u516c\u53f8\u603b\u90e8\uff0c\u4e5f\u8bb8\u4f1a\u6709\u591a\u4e2a\u4e0d\u540c\u7684\u5165\u53e3\uff0c\u5730\u5740\u4f1a\u6709\u591a\u4e2a\u4e0d\u540c\u7684\u5199\u6cd5\u3002\u5c3d\u91cf\u4e0e\u8bf4\u660e\u4e66\u4e0a\u7684\u5730\u5740\u4fdd\u6301\u4e00\u81f4\uff0c\u5f88\u591a\u65f6\u5019\uff0c\u4e0d\u9700\u8981\u5199\u8857\u9053\u5730\u5740\u3002\u53e6\u5916\u4e00\u65b9\u9762\uff0cGMP \u751f\u4ea7\u5546\u7684\u5730\u5740\uff0c\u4e00\u822c\u5fc5\u987b\u6709\u8857\u9053\u5730\u5740\uff0cFDA\u5bf9GMP\u8f66\u95f4\u7684\u5730\u5740\u7ba1\u7406\u975e\u5e38\u4e25\u683c\uff0c\u56e0\u4e3a\u5982\u679c\u6ca1\u6709\u8857\u9053\u5730\u5740\uff0cFDA\u68c0\u67e5\u4eba\u5458\uff0c\u68c0\u67e5\u65f6\uff0c\u627e\u4e0d\u5230\u5730\u65b9\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5982\u4f55\u6765\u786e\u8ba4GLUCOPHAGE XR \u7684GMP\u751f\u4ea7\u5546\u7684\u5730\u5740\uff1f\u9996\u5148\uff0c\u74f6\u5b50\u4e0a\u9762\u6ca1\u6709\u5199\u662f\u5176\u4ed6\u56fd\u5bb6\u751f\u4ea7\u7684\uff0c\u6211\u4eec\u5047\u8bbe\u662f\u7f8e\u56fd\u751f\u4ea7\u7684. \u7136\u540e\uff0c\u5230FDA GMP\u7684\u751f\u4ea7\u5546\u6570\u636e\u5e93\u4e2d\u67e5\u8be2\uff0cBristol-Myers Squibb Company \uff08BMS)<\/span> \u516c\u53f8\u6240\u62e5\u6709\u7684GMP\u5382\u7684\u5730\u5740\u3002\u67e5\u8be2\u7ed3\u679c\u89c1\u4e0b\u56fe\uff0c\u663e\u793aBMS\u516c\u53f8\u5728\u7f8e\u56fd\u67092\u4e2a\u751f\u4ea7\u5382\u7684\u5730\u5740\uff0c<\/span>\u90fd\u5728\u6ce2\u591a\u9ece\u5404 Puerto Rico\u3002<\/p>\n

\"\u5982\u4f55\u6765\u786e\u5b9a\u7f8e\u56fd\u53c2\u6bd4\u5236\u5242\u751f\u4ea7\u5546--\u683c\u534e\u6b62\u7f13\u91ca\u7247<\/p>\n


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\u4e0b\u9762\u6211\u4eec\u9700\u8981\u67e5\u8be2\u4e00\u822c\u6027\u7684\u4fe1\u606f\uff0c\u6bd4\u5982\u65b0\u95fb\uff0cFDA\uff14\uff18\uff13\uff0c\u5382\u5bb6\u8d22\u52a1\u5e74\u5ea6\u62a5\u8868\uff0c\u7b49\u4fe1\u606f\uff0c\u6765\u5224\u65adGLUCOPHAGE XR\u662f\u5728\u4e0a\u9762\uff12\u4e2a\u5382\u4e2d\u7684\u54ea\u4e00\u4e2a\u5382\u751f\u4ea7\u7684\uff1f<\/p>\n


<\/p>\n

\u7f8e\u56fd\u8fd9\u4e2a\u7f51\u7ad9\u63d0\u5230\u3000GLUCOPHAGE\u662f\u5728\u6ce2\u591a\u9ece\u5404Puerto Rico\u751f\u4ea7\u7684\uff0c\u201c3. Our research did not uncover evidence of the manufacture of this drug in Puerto Rico, but a company spokesperson volunteered that information to Insightus.\u201d\u3002\u53c2\u8003\u6587\u732e\u7f51\u7ad9\u8854\u63a5\uff1ahttp:\/\/insight-us.org\/puerto_rico_drugs_table.html\u3000\u3000\u3000<\/p>\n


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\u7f8e\u56fd\u8fd9\u4e2a\u65b0\u95fb\u62a5\u9053\u7684\u6700\u540e\u63d0\u5230\uff0c\u201c … BMS …  completed a $200 million project to expand its biologics manufacturing site in Manati  “\u3002\u6211\u4eec\u5c31\u53ef\u4ee5\u5224\u65ad\uff0cBMS\u5728\u6ce2\u591a\u9ece\u54042\u4e2aGMP\u5382\u4e2d\u4e00\u4e2a\uff0cMANATI\u662f\u7528\u6765\u751f\u4ea7\u751f\u7269\u836f\u54c1\u7684\uff0c\u6bd4\u5982\u6297\u4f53OPDIVO \uff08BMS\u516c\u53f8\u7684\u53d1\u8a00\u4eba\uff0c\u66fe\u7ecf\u786e\u8ba4\u8fc7OPDIVO\u662f\u5728MANATI\u751f\u4ea7\u7684\uff09\u3002<\/p>\n


<\/p>\n

\u8fd9\u6837\uff0c\u6211\u4eec\u53ef\u4ee5\u63a8\u65ad\uff0cGLUCOPHAGE XR\u7684\u751f\u4ea7\u5546\u5730\u5740\uff0c\u5e94\u8be5\u4e0d\u662f\u5728MANATI\u7684\uff0c\u800c\u662f\u5728\u53e6\u5916\u4e00\u4e2aBMS\u7684\u6ce2\u591a\u9ece\u5404\u7684GMP\u5730\u5740\uff0c\u5c31\u662f\u5728HUMACAO\u7684\u3002\u540c\u4e00\u7bc7\u65b0\u95fb\u91cc\u9762\u8fd8\u63d0\u5230\u201cA newly-constructed 82,000 sq. ft. unit will house new production lines for type II diabetes drugs\u201d\uff0cHUMACAO\u7684\u6269\u5efa\u662f\u4e3a\u4e86\u751f\u4ea7\u4e8c\u578b\u7cd6\u5c3f\u75c5\u7684\u836f\u7269\u7684\u3002 \u8fd9\u6837\uff0c\u6211\u4eec\u5c31\u6709\u4e00\u4e9b\u8bc1\u636e\u53ef\u4ee5\u6765\u731c\u6d4b\uff0cGLUCOPHAGE XR\u662f\u5728HUMACAO\u7684GMP\u8f66\u95f4\u751f\u4ea7\u7684\u3002 \u53c2\u8003\u6587\u732e\u7f51\u7ad9\u8854\u63a5\uff1ahttp:\/\/www.pharmafile.com\/news\/173447\/bms-unveils-165m-expansion-puerto-rico<\/p>\n


<\/p>\n

\u8fd9\u7bc7\u65b0\u95fb\u62a5\u9053\uff0c 2017\u5e74\u7684\u98d3\u98ce\u7834\u574f\u4e86\u6ce2\u591a\u9ece\u5404\uff0c\u5305\u62ecBMS\u5728HUMACAO\u7684\u5de5\u5382\uff0c\u7528\u53d1\u7535\u673a\u8fd0\u8f6c\uff0c\u96c7\u4f63\u5927\u7ea6300\u4e2a\u4eba\uff0c\u751f\u4ea7\u5fc3\u8840\u7ba1\u836f\u7269\uff0c\u548c\u6297\u7cd6\u5c3f\u75c5\u7684\u836f\u7269\u3002 <\/span>But as of mid-December, the U.S.-based pharmaceutical giant Bristol-Myers Squibb \u2014 which manufactures cardiovascular and anti-diabetes products and employs about 300 people \u2014 was still running on generators.  \u53c2\u8003\u6587\u732e\u7f51\u7ad9\u8854\u63a5\uff1a https:\/\/www.nbcnews.com\/storyline\/puerto-rico-crisis\/anger-grows-hope-fades-puerto-rico-s-ground-zero-remains-n833421<\/p>\n


<\/p>\n

\u8fd8\u6709\u4e00\u4e9b\u5176\u4ed6\u7684\u65b0\u95fb\uff0c\u5305\u62ecFDA\u7684483\u8b66\u544a\u4fe1\uff0c\u8bc1\u5b9e\u4e86HUMACAO\u7684\u5de5\u5382\u662f\u751f\u4ea7\u7247\u5242\u7684\uff0c\u548c\u6297\u7cd6\u5c3f\u75c5\u7684\u836f\u54c1\u7684\u3002 <\/span><\/p>\n

https:\/\/www.businesswire.com\/news\/home\/20120710006138\/en\/Bristol-Myers-Squibb-Announces-Humacao-Site-Expansion  \u548c<\/p>\n

https:\/\/www.sec.gov\/Archives\/edgar\/data\/14272\/000119312511040120\/d10k.htm<\/p>\n


<\/p>\n

\u7efc\u5408\u4e0a\u9762\u7684\u4fe1\u606f\uff0c\u6211\u4eec\u63a8\u7406\u51fa\u6765\u7684\u7ed3\u8bba\u662f\uff0cGLUCOPHAGE XR \u7684\u6301\u8bc1\u5546\uff1aBristol-Myers Squibb Company\uff0cPrinceton, NJ 08543 USA\uff1b\u751f\u4ea7\u5546\uff1aBristol-Myers Squibb Company\uff0cState Road No. 3 Km 77.5,  Humacao, Puerto Rico (PR) 00791, United States (USA)\u3002<\/p>\n

\u5f80\u671f\u7cbe\u5f69<\/span><\/strong><\/p>\n

\u4e00\u81f4\u6027\u8bc4\u4ef7\u76843\u5bb6\u4e0e3\u5e74<\/span><\/p>\n

\u6c47\u805a\u5357\u836f\u7275\u7ebf\u642d\u6865  \u6821\u4f01\u643a\u624b\u5171\u540c\u63a2\u7d22\u4eba\u624d\u57f9\u517b\u65b0\u6a21\u5f0f\u4e00\u4e00\u9996\u5c4aCRA\u4eba\u624d\u57f9\u8bad\u73ed\u7eaa\u5b9e<\/a><\/p>\n

\u540c\u5fc3\u7b51\u68a6\u2014\u2014\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u4e0a\u6d77\u6821\u53cb\u4f1a\u5e74\u4f1a\u4fa7\u8bb0<\/a><\/p>\n

\u3010\u6848\u4f8b\u8bf4\u3011\u6570\u636e&\u4e34\u5e8a\u4e4b\u771f\u5b9e\u4e16\u754c\u7814\u7a76<\/span><\/a><\/p>\n

\u6211\u4eec\u7684\u6bd5\u4e1a\u5b63<\/span><\/p>\n

\u91cd\u9022\u90a3\u4e9b\u76f8\u4f34\u8d70\u8fc7\u9752\u6625\u7684\u4eba\u2014\u201488\u7ea7\u8fdb\u682130\u5e74\u805a\u4f1a\u7eaa\u5b9e<\/a><\/p>\n

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<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u672c\u5fae\u4fe1\u516c\u4f17\u53f7\u6536\u5230\u5f88\u591a\u5173\u4e8e\u683c\u534e\u6b62\u7f13\u91ca\u7247GLUCOPHAGE XR\u53c2\u6bd4\u5236\u5242\u4e00\u6b21\u6027\u8fdb\u53e3\u7684\u54a8\u8be2\uff0c\u9700\u8981\u5e2e\u52a9\u786e\u8ba4\u751f\u4ea7\u5546\u548c\u6301 […]<\/p>\n","protected":false},"author":1,"featured_media":46294,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46293"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=46293"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46293\/revisions"}],"predecessor-version":[{"id":46299,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46293\/revisions\/46299"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/46294"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=46293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=46293"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=46293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}