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CAR-T<\/span><\/strong>\u9488\u5bf9CD19\u6297\u539f\u7684\u8840\u6db2\u7624\u6709\u8f83\u597d\u7684\u7597\u6548\uff0c2017\u5e74\u4e0b\u534a\u5e74\u4e24\u6b3eCAR-T\u4ea7\u54c1\u83b7\u6279\uff0c\u5305\u62ec\u8bfa\u534e\u7684Kymriah\u548cGilead\u7684Yescarta\uff0c\u9002\u5e94\u75c7\u5747\u4e3aB\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u65b9\u9762\u7597\u6548\u76ee\u524d\u4ecd\u6709\u5f85\u7a81\u7834\u3002<\/span><\/p>\n

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Provenge(Sipuleucel-T\uff0c\u666e\u5217\u5a01)\u662f\u7b2c\u4e00\u4e2a\u5728\u7f8e\u56fd\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u76ee\u7684\u7684\u80bf\u7624\u75ab\u82d7\uff0c\u5f00\u521b\u4e86\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u65b0\u65f6\u4ee3\u3002<\/span><\/strong><\/span><\/p>\n

2010\u5e744\u670829\u65e5\uff0c\u7f8e\u56fdFDA\u6b63\u5f0f\u6279\u51c6\uff0c\u5c06Dendreon\u516c\u53f8\u7684Provenge\u7528\u6765\u6cbb\u7597\u65e0\u75c7\u72b6\u6216\u5177\u6709\u8f7b\u5fae\u75c7\u72b6\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027(\u6fc0\u7d20\u96be\u6cbb\u6027)\u524d\u5217\u817a\u764c\uff0c\u6210\u4e3a\u9996\u4e2a\u88ab\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\u7684\u524d\u5217\u817a\u764c\u81ea\u4f53\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\uff0c\u8fd9\u6b3e\u80bf\u7624\u75ab\u82d7\u7684\u4e0a\u5e02\u6807\u5fd7\u7740\u8be5\u9886\u57df20\u5e74\u7684\u4e0d\u61c8\u52aa\u529b\u7ec8\u4e8e\u53d6\u5f97\u4e86\u6210\u529f\u3002<\/span><\/p>\n

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\u258c<\/span><\/span><\/span><\/span><\/span>\u80bf\u7624\u75ab\u82d7\u53d7\u5e02\u573a\u70ed\u6367\uff0c\u6709\u671b\u5207\u5165\u5343\u4ebf\u7f8e\u5143\u5e02\u573a<\/span><\/span><\/p>\n

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\u9274\u4e8e\u80bf\u7624\u75ab\u82d7\u7684\u7a81\u7834\u6027\u8fdb\u5c55\uff0c\u80bf\u7624\u75ab\u82d7\u5728\u878d\u8d44\u5e76\u8d2d\u65b9\u9762\u53d7\u5e02\u573a\u70ed\u6367\uff0c\u7279\u522b\u662f2013\u5e74\u8d77\uff0c\u878d\u8d44\u5e76\u8d2d\u9891\u7387\u52a0\u901f\u3002\u4ee5Dendreon\u4e3a\u4f8b\uff0c\u516c\u53f8\u5148\u540e\u4e8e2015\u5e74\u88abValeant\u4ee52.96\u4ebf\u7f8e\u5143\u6536\u8d2d\uff0c\u540e\u4e8e2017\u5e74\u88ab\u4e2d\u56fd\u4e09\u80de\u96c6\u56e2\u4ee58.19\u4ebf\u7f8e\u5143\u6536\u8d2d\uff0c\u53ef\u89c1\u5e02\u573a\u5bf9\u80bf\u7624\u75ab\u82d7\u53d1\u5c55\u7684\u4e50\u89c2\u6001\u5ea6\u3002<\/span><\/p>\n

\"\u80bf\u7624\u75ab\u82d7\uff1a\u91cd\u78c5\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u7684\u7834\u6653\"<\/p>\n

\u258c<\/span><\/span><\/span><\/span><\/span>\u4ece\u901a\u7528\u5230\u4e2a\u6027\u5316\uff0c\u80bf\u7624\u75ab\u82d7\u5e94\u7528\u5e7f\u6cdb\u524d\u666f\u5e7f\u9614<\/span><\/span><\/p>\n

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<\/p>\n

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\u4eba\u4f53\u5185\u51fa\u73b0\u7684\u764c\u75c7\u7279\u5f02\u6027\u7684\u65b0\u6297\u539f\u8868\u4f4d\u662f\u764c\u75c7\u75ab\u82d7\u7684\u7406\u60f3\u9776\u70b9\u3002\u968f\u7740\u6d4b\u5e8f\u6280\u672f\u4ee5\u53ca\u6570\u636e\u79d1\u5b66\u7684\u8fdb\u6b65\uff0c\u5feb\u901f\u4ece\u75c5\u4eba\u57fa\u56e0\u7ec4\u5185\u627e\u5230\u7a81\u53d8\u7684\u57fa\u56e0\u6216\u8005\u5f02\u5e38\u8868\u8fbe\u7684\u86cb\u767d\u6210\u4e3a\u4e86\u53ef\u80fd\uff0c\u5408\u7406\u7684\u9009\u62e9\u51fa\u9002\u7528\u4e8e\u75ab\u82d7\u5f00\u53d1\u7684\u9776\u70b9\u5e76\u9488\u5bf9\u7279\u5f02\u9776\u70b9\u5236\u4f5c\u75ab\u82d7\u6210\u4e3a\u80bf\u7624\u75ab\u82d7\u7814\u53d1\u7684\u91cd\u8981\u65b9\u5411\u3002<\/span><\/p>\n

\u5982\u8fd1\u671f\u5728\u300aScienceTranslationalMedicine\u300b\u4e0a\u7684\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u4e2a\u4f53\u5316\u75ab\u82d7\u5df2\u8ba9\u4e00\u540d\u665a\u671f\u5375\u5de2\u764c5\u5e74\u65e0\u764c\uff0c\u4e5f\u8ba9\u6211\u4eec\u770b\u5230\u4e86\u8fd9\u7c7b\u5168\u65b0\u7597\u6cd5\u7684\u65e0\u9650\u6f5c\u529b\u3002<\/span><\/p>\n

\u4e2a\u6027\u5316\u80bf\u7624\u75ab\u82d7\u7684\u5173\u952e\u8981\u7d20\u4e4b\u4e00\uff0c\u5728\u4e8e\u627e\u5230\u7cbe\u786e\u7684\u80bf\u7624\u7a81\u53d8\u4f4d\u70b9\uff0c\u5e76\u7531\u6b64\u9009\u62e9\u6700\u4f18\u514d\u75ab\u53cd\u5e94\u7684\u7a81\u53d8\u4f4d\u70b9\uff0c\u8fdb\u800c\u7528\u4e8e\u5236\u4f5c\u4e2a\u6027\u5316\u80bf\u7624\u75ab\u82d7\u3002\u524d\u671f\u5b9e\u9a8c\u5e38\u5229\u7528\u4e0b\u4e00\u4ee3\u6d4b\u5e8f(NGS)\u6280\u672f\uff0c\u6bd4\u8f83\u80bf\u7624\u6837\u672c\u4e0e\u6b63\u5e38\u7ec4\u7ec7\u7684\u57fa\u56e0\u7ec4\u5e8f\u5217\u7684\u5dee\u5f02\u3002<\/span><\/p>\n

\u4f46\u662f\uff0c\u76ee\u524d\u4ecd\u6709\u8bb8\u591a\u5c40\u9650\uff0c\u4e00\u65b9\u9762\u80bf\u7624\u6837\u672c\u7684\u4ee3\u8868\u6027\uff0c\u6d3b\u68c0\u83b7\u5f97\u7684\u80bf\u7624\u6837\u672c\u53ef\u80fd\u4e0d\u5177\u6709\u4ee3\u8868\u6027;\u53e6\u4e00\u65b9\u9762\uff0c\u76ee\u524d\u80fd\u786e\u4fdd\u7684\u662f\u6838\u82f7\u9178\u5e8f\u5217\u7f16\u8f91\u8bbe\u8ba1\u7684\u51c6\u786e\u6027\uff0c\u4f46\u4e0d\u80fd\u4fdd\u8bc1\u57fa\u56e0\u8f6c\u5f55\u3001\u7ffb\u8bd1\u53ca\u4fee\u9970\u540e\u7684\u8868\u89c2\u9057\u4f20\u5b66\u7684\u53ef\u9760\u6027\u3002<\/span><\/p>\n

\"\u80bf\u7624\u75ab\u82d7\uff1a\u91cd\u78c5\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u7684\u7834\u6653\"<\/p>\n


<\/p>\n

\u901a\u8fc7\u57fa\u56e0\u6d4b\u5e8f\u627e\u5230\u80bf\u7624\u7a81\u53d8\u4f4d\u70b9\u4e4b\u540e\uff0c\u5982\u4f55\u6311\u9009\u51fa\u6700\u5177\u6709\u514d\u75ab\u539f\u6027\u7684\u7a81\u53d8\u6210\u4e3a\u80bf\u7624\u75ab\u82d7\u5f00\u53d1\u7684\u5173\u952e\u56e0\u7d20\u3002<\/span><\/strong><\/p>\n

\u9274\u4e8e\u6210\u672c\u548c\u6280\u672f\u7684\u9650\u5236\uff0c\u76ee\u524d\u65e0\u6cd5\u5c06\u6240\u6709\u7684\u7a81\u53d8\u8bbe\u8ba1\u5230\u75ab\u82d7\u4e4b\u4e2d\uff0c\u73b0\u6709\u7684\u6311\u9009\u539f\u5219\u5305\u62ec\u7a81\u53d8\u57fa\u56e0\u5728\u80bf\u7624\u91cc\u7684\u8868\u8fbe\u91cf\uff0c\u6291\u6216\u662f\u7a81\u53d8\u4ea7\u751f\u201c\u53ef\u5448\u9012\u201d\u8868\u4f4d\u7684\u80fd\u529b\u3002\u4ee5\u53ca\u5982\u679c\u7279\u5b9a\u7684\u7a81\u53d8\u5728\u5f02\u8d28\u6027\u80bf\u7624\u7684\u591a\u4e2a\u514b\u9686\u91cc\u90fd\u666e\u904d\u5177\u6709\u8868\u8fbe\uff0c\u90a3\u4e48\u8be5\u7a81\u53d8\u201c\u6210\u75ab\u82d7\u201d\u7684\u6f5c\u529b\u53ef\u80fd\u4e5f\u66f4\u9ad8\u3002<\/span><\/p>\n

\u4e2a\u6027\u5316\u80bf\u7624\u75ab\u82d7\u5e76\u975e\u6613\u4e8b\uff0c\u9700\u8981\u7ecf\u5386\u9274\u522b\u7a81\u53d8\u3001\u9884\u6d4b\u8868\u4f4d\u3001\u8bbe\u8ba1\u75ab\u82d7\u3001\u751f\u4ea7\u75ab\u82d7\u8fd9\u4e00\u7cfb\u5217\u590d\u6742\u7684\u5de5\u4f5c\u3002<\/span><\/p>\n

\"\u80bf\u7624\u75ab\u82d7\uff1a\u91cd\u78c5\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u7684\u7834\u6653\"<\/p>\n

2018\u5e746\u6708\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u9ebb\u7701\u7684\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u516c\u53f8NeonTherapeutics\u9996\u6b21\u767b\u9646\u7eb3\u65af\u8fbe\u514b\u5e02\u573a\u3002NeonTherapeutics\u7684\u9886\u5148\u5728\u7814\u4ea7\u54c1\u662f\u764c\u75c7\u75ab\u82d7NEO-PV-01\u3002\u8fd9\u79cd\u75ab\u82d7\u65e8\u5728\u901a\u8fc7\u5bf9\u7279\u5f02\u7684\u80bf\u7624\u8868\u9762\u6297\u539f\u8fdb\u884c\u7b5b\u9009\uff0c\u7136\u540e\u7279\u5f02\u6027\u5730\u6fc0\u6d3b\u60a3\u8005\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u8fbe\u5230\u4e2a\u4f53\u5316\u6cbb\u7597\u764c\u75c7\u7684\u76ee\u7684\u3002<\/span><\/p>\n

2015\u5e7412\u6708\uff0cNeonTherapeutics\u66fe\u4e0e\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d(BMS)\u8fbe\u6210\u5408\u4f5c\uff0c\u5728\u4e00\u98791b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c06NEO-PV-01\u548cBMS\u7684PD-1\u6291\u5236\u5242Opdivo\u8054\u5408\u4f7f\u7528\uff0c\u65e8\u5728\u68c0\u6d4b\u8054\u5408\u7597\u6cd5\u5728\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u8180\u80f1\u764c\u7b49\u9886\u57df\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/span><\/p>\n

\u800c\u5728\u4eca\u5e745\u6708\uff0cNeonTherapeutics\u5ba3\u5e03\u4e0e\u9ed8\u6c99\u4e1c\u5408\u4f5c\uff0c\u5728\u4e00\u98791b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c06NEO-PV-01\u4e0e\u9ed8\u514b\u7684PD-1\u6291\u5236\u5242Keytruda\u548c\u5316\u7597\u8054\u7528\uff0c\u68c0\u6d4b\u5728\u672a\u7ecf\u6cbb\u7597\u6216\u665a\u671f\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u7ec6\u80de\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\uff0c\u8010\u53d7\u6027\u548c\u521d\u6b65\u7597\u6548\u3002<\/span><\/p>\n

\"\u80bf\u7624\u75ab\u82d7\uff1a\u91cd\u78c5\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u7684\u7834\u6653\"<\/span><\/p>\n

\u8054\u5408\u6cbb\u7597\u5927\u52bf\u6240\u8d8b\uff0c\u5927\u5e45\u964d\u4f4e\u80bf\u7624\u60a3\u8005\u6b7b\u4ea1\u7387<\/span><\/span><\/p>\n

\u76ee\u524d\u4e34\u5e8a\u8bd5\u9a8c\u4e0a\u80bf\u7624\u75ab\u82d7\u4e3b\u8981\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u7528\u836f\u3002\u514d\u75ab\u68c0\u67e5\u70b9\u5373\u4e3aT\u7ec6\u80de\u53cd\u5e94\u4e2d\u4e0e\u5171\u523a\u6fc0\u4fe1\u53f7\u76f8\u4e92\u8c03\u8282\u7684\u5171\u6291\u5236\u4fe1\u53f7\u3002<\/span><\/p>\n

\u5728\u751f\u7406\u60c5\u51b5\u4e0b\uff0c\u5171\u523a\u6fc0\u5206\u5b50\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u5206\u5b50\u4fdd\u6301\u5e73\u8861\uff0c\u4ece\u800c\u6700\u5927\u7a0b\u5ea6\u51cf\u5c11\u5bf9\u4e8e\u5468\u56f4\u6b63\u5e38\u7ec4\u7ec7\u7684\u635f\u4f24\uff0c\u7ef4\u6301\u5bf9\u81ea\u8eab\u7ec4\u7ec7\u7684\u8010\u53d7\u3001\u907f\u514d\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u3002\u800c\u80bf\u7624\u7ec6\u80de\u5219\u901a\u8fc7\u5f02\u5e38\u4e0a\u8c03\u5171\u6291\u5236\u5206\u5b50\u53ca\u5176\u76f8\u5173\u914d\u4f53\u7684\u9014\u5f84\uff0c\u6291\u5236T\u7ec6\u80de\u6fc0\u6d3b\uff0c\u4ece\u800c\u9003\u907f\u514d\u75ab\u6740\u4f24\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c\u6291\u5236\u8fc7\u91cf\u8868\u8fbe\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u5206\u5b50\u53ef\u589e\u5f3aT\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u5f62\u6210\u5177\u6709\u6301\u7eed\u6740\u4f24\u6d3b\u6027\u7684T\u7ec6\u80de\u3002\u800c\u80bf\u7624\u75ab\u82d7\u901a\u8fc7\u8f93\u5165\u80bf\u7624\u6297\u539f\u3001\u4f50\u5242\u6fc0\u6d3b\u4eba\u4f53\u7684APC\u7ec6\u80de\uff0c\u518d\u7531APC\u7ec6\u80de\u53bb\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u4ea7\u751f\u4e86\u7279\u5f02\u6027\u6740\u4f24\u80fd\u529b\u7684T\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u201c\u80bf\u7624\u75ab\u82d7+\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u201d\u8054\u5408\u7528\u836f\u53ef\u4ee5\u4ea7\u751f\u6709\u6548\u7684\u7279\u5f02\u6027\u6740\u4f24\u4e14\u6301\u7eed\u6d3b\u5316\u72b6\u6001\u7684T\u7ec6\u80de\uff0c\u5e76\u4e14\u963b\u6b62\u80bf\u7624\u7ec6\u80de\u5efa\u7acb\u6291\u5236\u6027\u80bf\u7624\u5fae\u73af\u5883\u3002<\/span><\/p>\n

\u5728\u4e00\u9879\u7814\u7a76Prostvac(BavarianNoridc\u516c\u53f8\u7684\u4e00\u6b3e\u75c5\u6bd2\u8f7d\u4f53\u7c7b\u80bf\u7624\u75ab\u82d7\u4ea7\u54c1)\u4e0eipilimumab\u8054\u7528\u6cbb\u7597\u8f6c\u79fb\u6027\u3001\u53bb\u52bf\u8010\u53d7\u578b\u524d\u5217\u817a\u764c\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d710mg\/kgipilimumab\u6cbb\u7597\u7684\u60a3\u8005\u603b\u4f53\u751f\u5b58\u671f\u4e3a26.6\u4e2a\u6708\uff0c\u8054\u5408Prostvac\u7ec4\u7684\u603b\u4f53\u751f\u5b58\u671f\u4e3a37.2\u4e2a\u6708\uff0c\u660e\u663e\u63d0\u9ad8\u4e86\u6cbb\u7597\u6548\u679c\u3002<\/span><\/p>\n

2017\u5e744\u6708BavarianNoridc\u516c\u53f8\u5ba3\u5e03\u5f00\u5c55\u5c06Prostvac\u4e0eBristol-MyersSquibb\u516c\u53f8\u7684ipilimumab\u3001nivolumab\u8054\u5408\u5e94\u7528\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6b64\u5916\uff0cJohnsHopkinsUniversity\u4e5f\u5f00\u59cb\u4e86\u5c06\u80bf\u7624\u75ab\u82d7GVAX\u4e0ePD1\u6291\u5236\u5242\u8054\u7528\u7684\u8bd5\u9a8c\u3002<\/span><\/p>\n

\"\u80bf\u7624\u75ab\u82d7\uff1a\u91cd\u78c5\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u7684\u7834\u6653\"<\/span><\/p>\n

\u258c<\/span><\/span><\/span><\/span><\/span>\u80bf\u7624\u75ab\u82d7\u9886\u57df\u6807\u6746\u2014Provenge\uff0c\u4ece0\u52301\u7684\u7a81\u7834<\/span><\/span><\/p>\n

\u5212\u65f6\u4ee3\u80bf\u7624\u75ab\u82d7\u4ea7\u54c1\uff0c\u5f00\u521b\u514d\u75ab\u6cbb\u7597\u65b0\u65f6\u4ee3<\/span><\/strong><\/p>\n

Provenge(Sipuleucel-T)\uff0c\u666e\u5217\u5a01\uff0c\u7b2c\u4e00\u4e2a\u5728\u7f8e\u56fd\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u76ee\u7684\u7684\u80bf\u7624\u75ab\u82d7\uff0c\u5f00\u521b\u4e86\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u65b0\u65f6\u4ee3\u3002<\/span><\/p>\n

2010\u5e744\u670829\u65e5\uff0c\u7f8e\u56fdFDA\u6b63\u5f0f\u6279\u51c6\uff0c\u5c06Dendreon\u516c\u53f8\u7684Provenge\u7528\u6765\u6cbb\u7597\u65e0\u75c7\u72b6\u6216\u5177\u6709\u8f7b\u5fae\u75c7\u72b6\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027(\u6fc0\u7d20\u96be\u6cbb\u6027)\u524d\u5217\u817a\u764c\uff0c\u6210\u4e3a\u9996\u4e2a\u88ab\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\u7684\u524d\u5217\u817a\u764c\u81ea\u4f53\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\uff0c\u8fd9\u6b3e\u80bf\u7624\u75ab\u82d7\u7684\u4e0a\u5e02\u6807\u5fd7\u7740\u8be5\u9886\u57df20\u5e74\u7684\u4e0d\u61c8\u52aa\u529b\u7ec8\u4e8e\u53d6\u5f97\u4e86\u6210\u529f\u3002<\/span><\/p>\n

\"\u80bf\u7624\u75ab\u82d7\uff1a\u91cd\u78c5\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u7684\u7834\u6653\"<\/p>\n


<\/span><\/strong><\/p>\n

\u63d0\u9ad8\u80bf\u7624\u75c5\u4eba\u751f\u5b58\u671f<\/span><\/strong><\/p>\n

Provenge\u662f\u4e00\u79cd\u8840\u6db2\u5236\u54c1\uff0c\u800c\u4e0d\u662f\u4e00\u79cd\u836f\u3002\u5b83\u7531\u8f7d\u6709\u91cd\u7ec4\u524d\u5217\u817a\u9178\u6027\u78f7\u9178\u9176(PAP)\u6297\u539f\u7684\u80bf\u7624\u60a3\u8005\u81ea\u8eab\u7684\u795e\u7ecf\u5143\u6811\u7a81\u7ec6\u80de(\u514d\u75ab\u7cfb\u7edf\u6297\u539f\u7684\u9012\u5448\u7ec6\u80de)\u6784\u6210\u3002PAP\u86cb\u767d\u8868\u8fbe\u4e8e\u7edd\u5927\u591a\u6570\u7684\u524d\u5217\u817a\u80bf\u7624\u7ec6\u80de\uff0c\u4e5f\u8868\u8fbe\u4e8e\u6b63\u5e38\u7684\u524d\u5217\u817a\u7ec4\u7ec7\u4e2d\uff0c\u53ea\u662f\u4ee5\u6781\u4f4e\u7684\u6c34\u5e73\u5b58\u5728\u4e8e\u5176\u4ed6\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u3002<\/span><\/p>\n

\u5728\u6cbb\u7597\u6027\u80bf\u7624\u75ab\u82d7Provenge\u4e2d\uff0cPAP\u6297\u539f\u878d\u5408\u4e8e\u4f5c\u4e3a\u4f50\u5242\u7684\u4e00\u79cd\u514d\u75ab\u523a\u6fc0\u7ec6\u80de\u56e0\u5b50\u2014\u2014\u7c92\u7ec6\u80de-\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50(GM-CSF)\uff0c\u6811\u7a81\u7ec6\u80de\u5219\u5c06PAP\u86cb\u767d\u6d88\u5316\u4e3a\u591a\u80bd\u800c\u5448\u73b0\u4e8e\u5176\u8868\u9762,\u5f53\u5176\u88ab\u91cd\u65b0\u56de\u8f93\u5165\u60a3\u8005\u4f53\u5185\u540e,\u53ef\u88ab\u514d\u75ab\u7cfb\u7edfT\u7ec6\u80de\u8bc6\u522b\uff0c\u800c\u63a5\u89e6\u8fc7\u8be5\u6297\u539f\u540e\u7684T\u7ec6\u80de\u80fd\u627e\u5230\u5e76\u6740\u706d\u8868\u8fbePAP\u6297\u539f\u7684\u764c\u7ec6\u80de\u3002<\/span><\/p>\n

Provenge\u6700\u65e9\u7684\u8bd5\u9a8c\u7ed3\u679c\u53d1\u8868\u57282000\u5e74\uff0c\u8bc1\u660e\u4e86\u8be5\u836f\u54c1\u5bf9\u514d\u75ab\u7cfb\u7edf\u6709\u8c03\u8282\u548c\u964d\u4f4ePSA\u7684\u4f5c\u7528\u30022006\u5e74\u8be5\u516c\u53f8\u5728\u65b0\u6cfd\u897f\u5efa\u7acb\u4e86\u751f\u4ea7\u8bbe\u65bd\uff0c\u4ee5\u751f\u4ea7\u7528\u4e8e\u4e34\u5e8a\u4e09\u671f\u6d4b\u8bd5\u7684\u836f\u7269\u3002\u5728\u8be5\u836f\u54c1\u4e0a\u5e02\u4e4b\u524d\uff0c\u8be5\u516c\u53f8\u5171\u8fdb\u884c\u4e86\u4e09\u6b21\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c\uff0c\u5e76\u6700\u7ec8\u57282009\u5e744\u6708\u5ba3\u5e03\u4e86\u6700\u540e\u4e00\u6b21\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002\u663e\u793a\u4f7f\u7528\u8be5\u836f\u7269\u7684\u75c5\u4eba\u7684\u5e73\u5747\u751f\u5b58\u65f6\u95f4\u63d0\u9ad8\u4e864.1\u4e2a\u6708\u30022009\u5e744\u670829\u65e5\uff0cFDA\u6279\u51c6\u4e86\u8be5\u836f\u54c1\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u524d\u5217\u817a\u764c\u75c5\u4eba\u3002<\/span><\/p>\n

\"\u80bf\u7624\u75ab\u82d7\uff1a\u91cd\u78c5\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u7684\u7834\u6653\"<\/span><\/p>\n

\u6613\u4e3b\u5357\u4eac\u65b0\u767e\uff0c\u4e2d\u56fd\u4f01\u4e1a\u83b7\u6d77\u5916\u539f\u521b\u836f\u7269<\/span><\/span><\/p>\n

2017\u5e741\u67089\u65e5\uff0c\u4e2d\u56fd\u6c11\u8425\u4f01\u4e1a\u4e09\u80de\u96c6\u56e2\u4e0e\u5168\u7403\u751f\u7269\u533b\u836f\u754c\u4f01\u4e1aValeant\u516c\u53f8\u5728\u65e7\u91d1\u5c71\u8fbe\u6210\u80a1\u6743\u6536\u8d2d\u534f\u8bae\uff0c\u4ee58.19\u4ebf\u7f8e\u5143\u6536\u8d2d\u540e\u8005\u65d7\u4e0b\u7f8e\u56fd\u751f\u7269\u533b\u836f\u516c\u53f8Dendreon100%\u80a1\u6743\uff0c\u521b\u4e0b\u4e2d\u56fd\u4f01\u4e1a\u6536\u8d2d\u7f8e\u56fd\u836f\u54c1\u7684\u6700\u5927\u4ea4\u6613\u7eaa\u5f55\u3002<\/span><\/p>\n

\u4e0d\u540c\u4e8e\u6b64\u524d\u4e2d\u4f01\u6536\u8d2d\u4eff\u5236\u836f\u54c1\uff0c\u8fd9\u662f\u4e2d\u56fd\u4f01\u4e1a\u5728\u7f8e\u56fd\u6536\u8d2d\u7684\u552f\u4e00\u539f\u521b\u836f\u7269\u3002\u6b64\u6b21\u5e76\u8d2d\u5b8c\u6210\u540e\u4e09\u80de\u96c6\u56e2\u5c06\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u524d\u5217\u817a\u764c\u7ec6\u80de\u514d\u75ab\u7597\u6cd5Provenge\u7684\u62e5\u6709\u8005\u3002\u76ee\u524dPROVENGE\u662f\u552f\u4e00\u7684\u524d\u5217\u817a\u764c\u7ec6\u80de\u6cbb\u7597\u7597\u6cd5\uff0c\u672a\u67653-5\u5e74\u6ca1\u6709\u5176\u5b83\u7684\u7597\u6cd5\u8fdb\u5165\u8be5\u9886\u57df\u3002<\/span><\/p>\n

\u4ece\u4ea7\u54c1\u9500\u552e\u6765\u770b\uff0cProvenge\u7684\u9002\u5e94\u75c7\u662f\u65e0\u75c7\u72b6\u6216\u8f7b\u5fae\u75c7\u72b6\u7684mCRPC\uff0c\u8fd9\u7c7b\u60a3\u8005\u76ee\u524d\u5728\u7f8e\u56fd\u7684\u4eba\u6570\u662f43000\u4eba\uff0c\u672a\u67655\u5e74\u5c06\u6309\u7167\u6bcf\u5e742%\u7a33\u5b9a\u589e\u957f\u3002<\/span><\/p>\n

\u9884\u8ba1\u52302021\u5e74\u524d\u5217\u817a\u764c\u836f\u7269\u5e02\u573a\u5c06\u4ee58.7%\u7684\u590d\u5408\u5e74\u5ea6\u589e\u957f\u7387\u589e\u957f\uff0c\u52302021\u5e74\u5e02\u573a\u5bb9\u91cf\u5c06\u589e\u957f\u5230136\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

\u76ee\u524dProvenge\u5355\u6b21\u6ce8\u5c04\u9500\u552e\u4ef7\u683c\u7ea6\u4e3a33,000\u7f8e\u5143\uff0c\u7531\u4e8e\u901a\u8d27\u81a8\u80c0\u7b49\u539f\u56e0\uff0cProvenge\u7684\u9500\u552e\u4ef7\u683c\u6bcf\u5e74\u5747\u4f1a\u6709\u4e00\u5b9a\u6bd4\u4f8b\u7684\u4e0a\u5347\u30022016\u5e74PROVENGE\u9500\u552e\u989d\u8d85\u8fc73\u4ebf\u7f8e\u5143\uff0c\u60a3\u8005\u4efd\u989d\u4e3a7%\u3002\u9884\u8ba1\u52302022\u5e74\uff0cProvenge\u7684\u9500\u552e\u989d\u5c06\u8fbe\u52305\u4ebf\u7f8e\u5143\uff0c\u5e02\u573a\u5360\u6709\u7387\u5c06\u8fbe\u52309%\u3002<\/span><\/p>\n

\u258c<\/span><\/span><\/span><\/span><\/span>\u6536\u8d2d+\u81ea\u4e3b\u7814\u53d1\u63a8\u52a8\u56fd\u5185\u884c\u4e1a\u53d1\u5c55<\/span><\/span><\/p>\n

\u76ee\u524d\u4e2d\u56fd\u5728\u7814\u80bf\u7624\u75ab\u82d7\u9879\u76ee\u5171\u8ba147\u4e2a\uff0c\u5728\u5168\u7403\u8303\u56f4\u5185\u4ec5\u6b21\u4e8e\u7f8e\u56fd\u548c\u6b27\u6d32\u30022017\u5e747\u6708\u4e09\u80de\u96c6\u56e2\u4ee58.19\u4ebf\u7f8e\u5143\u7684\u4ef7\u683c\u6536\u8d2d\u62e5\u6709\u5168\u7403\u552f\u4e00\u80bf\u7624\u75ab\u82d7\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u7684\u4f01\u4e1aDendreon\uff0c\u5c06\u6781\u5927\u63a8\u52a8\u56fd\u5185\u6cbb\u7597\u6027\u80bf\u7624\u75ab\u82d7\u5e02\u573a\u7684\u53d1\u5c55\u3002\u6b64\u5916\uff0c\u5305\u62ec\u6d77\u6b23\u80a1\u4efd\u548c\u897f\u6bd4\u66fc\u751f\u7269\u5728\u5185\u7684\u4f01\u4e1a\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u53d6\u5f97\u4e00\u5b9a\u7684\u4e34\u5e8a\u8fdb\u5c55\u3002\u540c\u65f6\uff0c\u56fd\u5916\u516c\u53f8\u4e5f\u901a\u8fc7\u5408\u4f5c\u5728\u4e2d\u56fd\u8fdb\u884c\u4e34\u5e8a\u548c\u5546\u4e1a\u5316\uff0c\u8fd9\u5bf9\u6574\u4e2a\u884c\u4e1a\u90fd\u6709\u6781\u5927\u4fc3\u8fdb\u4f5c\u7528\uff0c\u56fd\u5185\u5e02\u573a\u524d\u666f\u5149\u660e\u3002<\/span><\/p>\n

\u62a5\u544a\u6765\u6e90\uff1a\u897f\u5357\u8bc1\u5238\uff08\u6731\u56fd\u5e7f\u3001\u9648\u94c1\u6797\uff09<\/span><\/p>\n

\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/p>\n

2018\u56fd\u9645\u5316\u6ce8\u518c\u4e13\u5458\u6280\u80fd\u63d0\u5347\u4e13\u9898\u57f9\u8bad\u73ed-\u4e0a\u6d77\u7ad9<\/span><\/a><\/span><\/strong><\/span><\/p>\n

“\u65b0\u836f\u5f00\u53d1\u4e2d\u7684\u9879\u76ee\u7ba1\u7406\u548c\u6cd5\u89c4\u6ce8\u518c\u7b56\u7565”(\u6b66\u6c49\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/a><\/span><\/strong><\/span><\/p>\n

\u7b2c\u4e8c\u671f\u201c\u4e34\u5e8a\u8bd5\u9a8c\u7528\u836fGMP\u5236\u5ea6\u8981\u70b9\u89e3\u6790\u53ca\u5e94\u7528\u5b9e\u65bd<\/a><\/span><\/strong><\/span><\/p>\n

\u3010\u6b63\u5728\u62db\u751f\u3011\uff089\u6708\u6d4e\u5357\uff09\u5236\u836f\u4f01\u4e1a\u9a8c\u8bc1\u7ba1\u7406\u9ad8\u7ea7\u7814\u4fee\u73ed\uff08\u7b2c\u516d\u671f\uff09<\/a><\/span><\/strong><\/span><\/p>\n

\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u751f\u7269\u5236\u54c1\u5708\u521b\u59cb\u4eba\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5708\u5fae\u4fe1\u7fa4\uff01<\/span><\/strong>
<\/p>\n

\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/span><\/strong><\/span><\/p>\n

\"\u80bf\u7624\u75ab\u82d7\uff1a\u91cd\u78c5\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u7684\u7834\u6653\"<\/p>\n

\"\u80bf\u7624\u75ab\u82d7\uff1a\u91cd\u78c5\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u7684\u7834\u6653\"<\/span><\/p>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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<\/span><\/strong><\/span>\u7248<\/section>\n<\/section>\n
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\u672c\u516c\u4f17\u53f7\u6240\u6709\u8f6c\u8f7d\u6587\u7ae0\u7cfb\u51fa\u4e8e\u4f20\u9012\u66f4\u591a\u4fe1\u606f\u4e4b\u76ee\u7684\uff0c\u4e14\u660e\u786e\u6ce8\u660e\u6765\u6e90\u548c\u4f5c\u8005\uff0c\u4e0d\u5e0c\u671b\u88ab\u8f6c\u8f7d\u7684\u5a92\u4f53\u6216\u4e2a\u4eba\u53ef\u4e0e\u6211\u4eec\u8054\u7cfb(cbplib@163.com)\uff0c\u6211\u4eec\u5c06\u7acb\u5373\u8fdb\u884c\u5220\u9664\u5904\u7406\u3002\u6240\u6709\u6587\u7ae0\u4ec5\u4ee3\u8868\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u7ad9\u7acb\u573a\u3002<\/span>
<\/p>\n

\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u258c\u80bf\u7624\u75ab\u82d7\u5907\u53d7\u77a9\u76ee\uff0c\u6210\u5b9e\u4f53\u7624\u6cbb\u7597\u91cd\u8981\u7a81\u7834\u53e3 \u76ee\u524d\uff0c\u4e3b\u8981\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u5305\u62ec\u6cbb\u7597\u6027\u80bf\u7624\u75ab\u82d7\u3001\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u3001 […]<\/p>\n","protected":false},"author":1,"featured_media":46798,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46797"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=46797"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46797\/revisions"}],"predecessor-version":[{"id":46815,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/46797\/revisions\/46815"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/46798"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=46797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=46797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=46797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}