{"id":46900,"date":"2018-09-19T01:00:00","date_gmt":"2018-09-26T01:33:13","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e5%9f%ba%e7%9f%b3%e8%8d%af%e4%b8%9a%e7%99%bd%e8%a1%80%e7%97%85%e6%96%b0%e8%8d%af3%e6%9c%9f%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e8%8e%b7%e6%89%b9%ef%bc%8c%e5%8d%b3%e5%b0%86%e5%9c%a8%e4%b8%ad%e5%9b%bd\/"},"modified":"2018-09-26T09:33:14","modified_gmt":"2018-09-26T01:33:14","slug":"%e5%9f%ba%e7%9f%b3%e8%8d%af%e4%b8%9a%e7%99%bd%e8%a1%80%e7%97%85%e6%96%b0%e8%8d%af3%e6%9c%9f%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e8%8e%b7%e6%89%b9%ef%bc%8c%e5%8d%b3%e5%b0%86%e5%9c%a8%e4%b8%ad%e5%9b%bd","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/46900\/","title":{"rendered":"\u57fa\u77f3\u836f\u4e1a\u767d\u8840\u75c5\u65b0\u836f3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u6279\uff0c\u5373\u5c06\u5728\u4e2d\u56fd\u542f\u52a8\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"max-width: 100%;min-height: 1em;color: 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0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 445px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537925594.jpg\" alt=\"\u57fa\u77f3\u836f\u4e1a\u767d\u8840\u75c5\u65b0\u836f3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u6279\uff0c\u5373\u5c06\u5728\u4e2d\u56fd\u542f\u52a8\uff01\" title=\"\u57fa\u77f3\u836f\u4e1a\u767d\u8840\u75c5\u65b0\u836f3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u6279\uff0c\u5373\u5c06\u5728\u4e2d\u56fd\u542f\u52a8\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f5c\u4e3a\u4e00\u5bb6\u805a\u7126\u80bf\u7624\u6cbb\u7597\u9886\u57df\u7684\u521b\u65b0\u751f\u7269\u5236\u836f\u4f01\u4e1a\uff0c\u57fa\u77f3\u836f\u4e1a\u4e0d\u4ec5\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u521b\u65b0\uff0c\u4e5f\u901a\u8fc7\u5546\u52a1\u62d3\u5c55\u548c\u5916\u90e8\u6218\u7565\u5408\u4f5c\uff0c\u4ee5\u671f\u7b2c\u4e00\u65f6\u95f4\u4e3a\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u6700\u5177\u7a81\u7834\u6027\u7684\u6297\u80bf\u7624\u6cbb\u7597\uff0c\u9020\u798f\u80bf\u7624\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">2018\u5e746\u6708\uff0c\u57fa\u77f3\u836f\u4e1a\u4e0eAgios\u5236\u836f\u516c\u53f8\u5ba3\u5e03\u8fbe\u6210\u72ec\u5bb6\u5408\u4f5c\u4e0e\u6388\u6743\u8bb8\u53ef\u534f\u8bae\uff0c\u63a8\u8fdbivosidenib\u5728\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u53ca\u53f0\u6e7e\u5730\u533a\uff08\u201c\u5927\u4e2d\u534e\u533a\u201d\uff09\u7684\u4e34\u5e8a\u5f00\u53d1\u4e0e\u5546\u4e1a\u5316\uff1b<\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">7\u6708\uff0c\u7f8e\u56fdFDA\u63d0\u524d\u4e0a\u5e02\u6279\u51c6\u7684\u6377\u62a5\u4f20\u6765\uff0civosidenib\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u5177\u67091DH1\u57fa\u56e0\u7a81\u53d8\u7684\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\u7684\u6210\u4eba\u60a3\u8005\uff1b<\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">9\u6708\uff0cAGILE\u76843\u671f\u5168\u7403\u8bd5\u9a8c\u53d6\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u4ef6\uff0c\u8fd9\u662f\u4e24\u5bb6\u516c\u53f8\u5408\u4f5c\u7684\u4e00\u9879\u91cc\u7a0b\u7891\u4e8b\u4ef6\u3002<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u77f3\u836f\u4e1a\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u6c5f\u5b81\u519b\u535a\u58eb\u8868\u793a\uff1a\u201c\u975e\u5e38\u632f\u594b\u57fa\u77f3\u5373\u5c06\u8d1f\u8d23\u542f\u52a8\u5728\u4e2d\u56fd\u7684AGILE\u8bd5\u9a8c\u3002Ivosidenib\u662f\u4e00\u4e2a\u9488\u5bf9IDH1\u57fa\u56e0\u7a81\u53d8\u7684\u3001\u540c\u7c7b\u9996\u521b\u7684\u53e3\u670d\u9776\u5411\u6291\u5236\u5242\uff0c\u80fd\u4e3a\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u5e26\u6765\u663e\u8457\u83b7\u76ca\u3002\u5e0c\u671b\u4ee5\u57fa\u77f3\u901f\u5ea6\uff0c\u9ad8\u6548\u63a8\u8fdb\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u4e2d\u56fd\u80bf\u7624\u60a3\u8005\u4e5f\u53ef\u4ee5\u540c\u6b65\u53d7\u76ca\u4e8e\u6700\u524d\u6cbf\u7684\u6cbb\u7597\u3002\u201c<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5173\u4e8eAML<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">AML\u662f\u6210\u4eba\u4e2d\u6700\u5e38\u89c1\u7684\u6025\u6027\u767d\u8840\u75c5\uff0c\u7f8e\u56fd\u9884\u8ba1\u6bcf\u5e74\u65b0\u53d1\u75c5\u4f8b\u8d85\u8fc7\u4e24\u4e07\u4f8b\uff0c\u4e2d\u56fd\u9884\u8ba1\u6bcf\u5e74\u65b0\u53d1\u75c5\u4f8b\u8d85\u8fc7\u4e09\u4e07\u4f8b\u3002AML\u901a\u5e38\u8fdb\u5c55\u8fc5\u901f\uff0c\u4e14\u5927\u591a\u6570\u60a3\u8005\u6700\u7ec8\u4f1a\u5bf9\u6cbb\u7597\u4ea7\u751f\u8010\u836f\u6216\u590d\u53d1\uff0c\u53d1\u5c55\u4e3aR\/R AML\u3002R\/R 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0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u90e8\u5206AML\u60a3\u8005\u643a\u5e26IDH1\u7a81\u53d8\uff0cIDH1\u7a81\u53d8\u4f53\u9176\u5bfc\u81f4\u5f02\u5e38\u7684\u4ee3\u8c22\u4ea7\u7269\u7d2f\u79ef\uff0c\u963b\u65ad\u6b63\u5e38\u7684\u8840\u6db2\u5e72\u7ec6\u80de\u5206\u5316\uff0c\u662fAML\u7684\u53d1\u751f\u548c\u53d1\u5c55\u7684\u673a\u5236\u4e4b\u4e00\u3002\u901a\u8fc7\u963b\u65adIDH1\u7a81\u53d8\u4f53\u9176\u7684\u6d3b\u6027\uff0c\u53ef\u4fc3\u8fdbAML\u7ec6\u80de\u7684\u5206\u5316\uff0c\u4ece\u800c\u53d1\u6325\u6297\u80bf\u7624\u6548\u5e94\u3002\u4e2d\u56fdAML\u60a3\u8005\u7684IDH1\u7a81\u53d8\u7387\u7ea6\u4e3a6-10%\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5173\u4e8eivosidenib\uff08TIBSOVO; AG-120\uff09<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">Ivosidenib\u662f\u4e00\u6b3e\u540c\u7c7b\u9996\u521b\u7684\u3001\u5177\u6709\u9009\u62e9\u6027\u7684\u3001\u9488\u5bf9IDH1\u57fa\u56e0\u7a81\u53d8\u764c\u75c7\u7684\u5f3a\u6548\u53e3\u670d\u9776\u5411\u6291\u5236\u5242\u3002IDH1\u662f\u4e00\u79cd\u4ee3\u8c22\u9176\uff0c\u5176\u57fa\u56e0\u7a81\u53d8\u5b58\u5728\u4e8e\u5305\u62ec\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u3001\u80c6\u7ba1\u764c\u548c\u795e\u7ecf\u80f6\u8d28\u7624\u5728\u5185\u7684\u591a\u79cd\u80bf\u7624\u3002Ivosidenib\u76ee\u524d\u5df2\u4e8e2018\u5e747\u6708\u83b7\u5f97\u7f8e\u56fdFDA\u7684\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u60a3\u6709\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u9ad3\u6027\u767d\u8840\u75c5\u7684\u6210\u4eba\u60a3\u8005\u3002\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u7814\u7a76\u4e3a8\u9879\uff0c\u5176\u4e2d2\u9879\u4e3a\u5168\u74033\u671f\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u2022\u009e3\u671fAGILE\u4e34\u5e8a\u7814\u7a76AGILE\uff1a\u8bc4\u4f30ivosidenib\u8054\u5408\u963f\u624e\u80de\u82f7\uff08azacitidine\uff09\u7528\u4e8e\u6cbb\u7597\u65b0\u8bca\u65ad\u7684IDH1\u57fa\u56e0\u7a81\u53d8\u4e14\u4e0d\u80fd\u591f\u63a5\u53d7\u6807\u51c6\u5316\u7597\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u7684\u7597\u6548<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u2022\u009e3\u671f\u4e34\u5e8a\u7814\u7a76\uff1a\u8bc4\u4f30ivosidenib\u6cbb\u7597IDH1\u57fa\u56e0\u7a81\u53d8\u7684\u665a\u671f\u80c6\u7ba1\u764c\u7684\u7597\u6548<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5173\u4e8e\u57fa\u77f3\u836f\u4e1a<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u77f3\u836f\u4e1a\u662f\u4e00\u5bb6\u4ee5\u521b\u65b0\u836f\u7814\u53d1\u4e3a\u9a71\u52a8\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u80bf\u7624\u514d\u75ab\u836f\u7269\u7684\u5f00\u53d1\u53ca\u5176\u8054\u5408\u7528\u836f\u7814\u7a76\uff0c\u62e5\u6709\u4e30\u5bcc\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3002\u76ee\u524d\uff0c\u4ea7\u54c1\u7ba1\u7ebf\u4e2d\u5df2\u6709\u5341\u56db\u4e2a\u6297\u80bf\u7624\u4ea7\u54c1\uff0c\u5176\u4e2d\u516b\u4e2a\u5904\u4e8e\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u4e09\u4e2a\u5df2\u5728\u56fd\u5185\u5916\u5f00\u5c55\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u3002\u57fa\u77f3\u836f\u4e1a\u7ba1\u7406\u56e2\u961f\u6210\u5458\u5747\u4e3a\u6765\u81ea\u56fd\u9645\u9876\u7ea7\u836f\u4f01\u7684\u8d44\u6df1\u9ad8\u7ba1\uff0c\u5df2\u6210\u529f\u6784\u5efa\u8d77\u4e00\u652f\u4ee5\u4e34\u5e8a\u7814\u53d1\u53ca\u8f6c\u5316\u533b\u5b66\u4e3a\u6838\u5fc3\u7ade\u4e89\u529b\u7684\u56e2\u961f\u3002\u516c\u53f8\u5df2\u5148\u540e\u4e8e2016\u5e747\u6708\u30012018\u5e745\u6708\u5b8c\u6210\u7531\u77e5\u540dVC\/PE\u57fa\u91d1\u6295\u8d44\u76841.5\u4ebf\u7f8e\u5143\uff08\u7ea69.75\u4ebf\u4eba\u6c11\u5e01\uff09A\u8f6e\u878d\u8d44\u548c2.6\u4ebf\u7f8e\u5143\uff08\u7ea616.5\u4ebf\u4eba\u6c11\u5e01\uff09B\u8f6e\u878d\u8d44\u3002\u5728\u7ba1\u7406\u56e2\u961f\u3001\u4ea7\u54c1\u7ebf\u3001\u7814\u53d1\u6a21\u5f0f\u53ca\u8d44\u91d1\u65b9\u9762\u7684\u72ec\u7279\u4f18\u52bf\uff0c\u5c06\u4f7f\u57fa\u77f3\u836f\u4e1a\u6210\u4e3a\u8de8\u56fd\u836f\u4f01\u4e0e\u56fd\u9645\u751f\u7269\u5236\u836f\u516c\u53f8\u5728\u4e2d\u56fd\u4ee5\u53ca\u4e9a\u592a\u5730\u533a\u8fdb\u884c\u4ea7\u54c1\u5171\u540c\u5f00\u53d1\u7684\u6700\u4f73\u5408\u4f5c\u4f19\u4f34\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\">[1] Ivosidenib\uff08TIBSOVO\uff09\u5168\u7403\u4e09\u671f\u8bd5\u9a8c\uff08AGILE\uff09\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u5373\u5c06\u5728\u4e2d\u56fd\u542f\u52a8\u4e34\u5e8a\u7814\u7a76.&nbsp;Retrieved September 17, 2018, from&nbsp;<\/span><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u77f3\u836f\u4e1a\u5b98\u5fae.<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 16px;font-family: Helvetica, Arial, sans-serif;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-size: 20px;font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u751f\u7269\u5236\u54c1\u5708\u521b\u59cb\u4eba\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5708\u5fae\u4fe1\u7fa4\uff01<\/span><\/strong><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 16px;font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 209, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"      width=\"269px\"  style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: 269px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537925594.jpeg\" alt=\"\u57fa\u77f3\u836f\u4e1a\u767d\u8840\u75c5\u65b0\u836f3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u6279\uff0c\u5373\u5c06\u5728\u4e2d\u56fd\u542f\u52a8\uff01\" title=\"\u57fa\u77f3\u836f\u4e1a\u767d\u8840\u75c5\u65b0\u836f3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u6279\uff0c\u5373\u5c06\u5728\u4e2d\u56fd\u542f\u52a8\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 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