{"id":46912,"date":"2018-09-19T01:00:00","date_gmt":"2018-09-26T01:33:19","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/car-t%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%e4%ba%a7%e5%93%81%e7%94%9f%e4%ba%a7%e7%9a%84%e6%8c%91%e6%88%98%e5%92%8c%e8%80%83%e9%87%8f\/"},"modified":"2018-09-26T09:33:21","modified_gmt":"2018-09-26T01:33:21","slug":"car-t%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%e4%ba%a7%e5%93%81%e7%94%9f%e4%ba%a7%e7%9a%84%e6%8c%91%e6%88%98%e5%92%8c%e8%80%83%e9%87%8f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/46912\/","title":{"rendered":"Car-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u751f\u4ea7\u7684\u6311\u6218\u548c\u8003\u91cf"},"content":{"rendered":"
\n

\u5c3d\u7ba1\u8fd1\u4e24\u5e74\uff0cCar-T\u7ec6\u80de\u6cbb\u7597\u6280\u672f\u5f97\u5230\u4e86\u98de\u8dc3\u5f0f\u7684\u53d1\u5c55\uff0c\u5176\u5177\u6709\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u672a\u6765\u53ef\u80fd\u53ef\u7528\u4e8e\u9488\u5bf9\u80bf\u7624\u7684\u6807\u51c6\u533b\u7597\u4f53\u7cfb\u3002\u4f46\u4ece\u8bb8\u591a\u65b9\u9762\u6765\u770b\uff0c\u83b7\u5f97\u6027T\u7ec6\u80de\u514d\u75ab\u4ecd\u5904\u5728\u8d77\u6b65\u9636\u6bb5\uff0cT\u7ec6\u80de\u751f\u4ea7\u7684\u5de5\u827a\u76f8\u5f53\u590d\u6742\uff0c\u5176\u7531\u591a\u4e2a\u6b65\u9aa4\u7ec4\u6210\uff0c\u5305\u62ecT\u7ec6\u80de\u5bcc\u96c6\u3001\u6d3b\u5316\u3001\u8f6c\u5bfc\u3001\u6269\u589e\u4ee5\u53ca\u5236\u5242\/\u51bb\u5e72\u3002\u6bcf\u4e2a\u6b65\u9aa4\u53c8\u53d7\u591a\u79cd\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5305\u62ec\u201c\u79cd\u5b50\u201d\u6216\u8d77\u59cb\u7ec6\u80de\u7fa4\u843d\u7684\u7ec4\u6210\u3001T\u7ec6\u80de\u6d3b\u5316\u7684\u65b9\u6cd5\u3001\u6297\u539f\u53d7\u4f53\u8f6c\u57fa\u56e0\u9012\u9001\u8f7d\u4f53\u3001\u57fa\u56e0\u7f16\u8f91\u7684\u6548\u7387\u3001\u7ec6\u80de\u5904\u7406\u80fd\u529b\u4ee5\u53ca\u6700\u7ec8\u7684\u4ea7\u54c1\u63a7\u5236\u3002\u5382\u5546\u3001\u79d1\u7814\u4ee5\u53ca\u76d1\u7ba1\u7b49\u56e2\u961f\u4e4b\u95f4\u9700\u8981\u6301\u7eed\u7684\u5408\u4f5c\uff0c\u805a\u7126\u4e8e\u4e00\u4e2a\u53ef\u83b7\u5f97\u6301\u7eed\u6539\u8fdb\u7684\u201c\u53cd\u9988\u201d\u56de\u8def\uff0c\u9a71\u52a8\u5de5\u827a\u7684\u4f18\u5316\uff0c\u6700\u7ec8\u83b7\u5f97\u53ef\u201c\u771f\u6b63\u201d\u5546\u54c1\u5316\u7684Car-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\"Car-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u751f\u4ea7\u7684\u6311\u6218\u548c\u8003\u91cf\"<\/p>\n

Car-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u751f\u4ea7\u7684\u6311\u6218\u548c\u8003\u91cf\uff08J.Xu, et al, 2018\uff09<\/span><\/em>
<\/span><\/p>\n


<\/span><\/strong><\/p>\n

T\u7ec6\u80de\u751f\u4ea7\u7684\u53ef\u91cd\u590d\u6027\u4ee5\u53ca\u53ef\u653e\u5927\u6027<\/span><\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u6700\u5f00\u59cb\u7684\u5927\u90e8\u5206\u7684Car-T\u7ec6\u80de\u751f\u4ea7\u8bbe\u65bd\u4f4d\u4e8e\u79d1\u7814\u673a\u6784\u4e2d\uff0c\u5982\u7f8e\u56fd\u7684\u5bbe\u5dde\u5927\u5b66\u4ee5\u53ca\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u3002\u8bb8\u591a\u8fd9\u6837\u7684\u5b66\u672f\u4e2d\u5fc3\u90fd\u4f1a\u9009\u62e9\u8ddf\u4e0d\u540c\u89c4\u6a21\u7684\u5236\u836f\u516c\u53f8\u5f62\u6210\u6218\u7565\u6027\u7684\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\uff0c\u76ee\u6807\u662f\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u7684\u5546\u4e1a\u5316\u3002\u5176\u751f\u4ea7\u8bbe\u65bd\u65e8\u5728\u83b7\u5f97\u60a3\u8005\u7279\u5f02\u6027\u7684\u7ec6\u80de\u4ea7\u54c1\uff0c\u7528\u4e8eI\u671f\u548cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u8fd9\u79cd\u751f\u4ea7\u8fc7\u7a0b\u4f9d\u8d56\u4e8e\u719f\u7ec3\u7684\u7ec6\u80de\u751f\u4ea7\u4eba\u5458\u4ee5\u53ca\u6570\u4e2a\u5f00\u653e\u5f0f\u64cd\u4f5c\u6b65\u9aa4\u3002\u5728\u8fd9\u4e9b\u5f00\u653e\u5f0f\u64cd\u4f5c\u6b65\u9aa4\u4e2d\uff0c\u5373\u4f7f\u6781\u5c0f\u7a0b\u5ea6\u7684\u53d8\u5f02\u6027\uff0c\u4e5f\u4f1a\u5f71\u54cd\u6700\u7ec8\u7ec6\u80de\u4ea7\u54c1\u7684\u8d28\u91cf\u3002\u6240\u4ee5\uff0c\u590d\u5236\u9ad8\u5ea6\u4f9d\u8d56\u4eba\u5de5\u7684\u5de5\u827a\u7a0b\u5e8f\uff0c\u5bf9\u4e8eCar-T\u7ec6\u80de\u751f\u4ea7\u7684\u89c4\u6a21\u6269\u5c55\u4ecd\u662f\u4e00\u4e2a\u4e3b\u8981\u7684\u6311\u6218\u3002\u800c\u53c8\u56e0\u4e3aCar-T\u7ec6\u80de\u53ef\u7528\u4e8e\u9776\u5411\u4e0d\u540c\u7c7b\u578b\u7684\u80bf\u7624\uff0c\u8f6c\u57fa\u56e0\u9012\u9001\u8f7d\u4f53\u548c\u6700\u7ec8\u7ec6\u80de\u4ea7\u54c1\u7684\u751f\u4ea7\u89c4\u6a21\u8fd8\u53d6\u51b3\u4e0e\u6bcf\u79cd\u9002\u5e94\u75c7\u7684\u53d1\u751f\u7387\u3002\u6b64\u5916\uff0c\u5bf9\u4e8e\u53ef\u9884\u6d4b\u7684\u7ec6\u80de\u57fa\u56e0\u5de5\u7a0b\uff0c\u4e00\u81f4\u3001\u7a33\u5065\u7684\u8f6c\u57fa\u56e0\u9012\u9001\u5e73\u53f0\u7684\u751f\u4ea7\u5fc5\u9700\u8003\u8651\u57fa\u56e0\u6cbb\u7597\u7684\u957f\u671f\u5b89\u5168\u6027\u4ee5\u53ca\u9884\u671f\u7684\u6cd5\u89c4\u9650\u5236\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u63d0\u9ad8\u7ec6\u80de\u751f\u4ea7\u6548\u7387<\/span><\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u56f4\u7ed5Car-T\u7ec6\u80de\u6cbb\u7597\u7684\u77e5\u8bc6\u7684\u7206\u53d1\u6027\u589e\u957f\uff0c\u4f7f\u5f97\u5bf9\u5982\u4f55\u63d0\u9ad8\u6bcf\u4e2aCar-T\u751f\u4ea7\u6b65\u9aa4\u6548\u7387\u6709\u4e86\u66f4\u6df1\u5165\u7684\u4e86\u89e3\u3002\u6b64\u5916\uff0c\u4e34\u5e8aT\u7ec6\u80de\u751f\u4ea7\u65f6\uff0c\u8fd8\u5fc5\u9700\u8003\u8651\u4ee5\u4e0b\u57fa\u672c\u8981\u6c42\u3002\u9996\u5148\uff0c\u751f\u4ea7\u8fc7\u7a0b\u5fc5\u9700\u4f18\u5316\uff0c\u4ee5\u83b7\u5f97\u53ef\u7528\u4e8e\u60a3\u8005\u7684\u5b89\u5168\u4e14\u7a33\u5065\u7684\u7ec6\u80de\u4ea7\u54c1\u3002\u6765\u81ea\u60a3\u8005\u7684\u529f\u80fd\u6027T\u7ec6\u80de\u7684\u4f18\u5316\u7b5b\u9009\u4ee5\u53ca\u6269\u589e\/\u57f9\u517b\uff08\u5305\u62ecT-\u7ec6\u80de\u523a\u6fc0\u56e0\u5b50\u3001\u57f9\u517b\u57fa\u3001\u7ec6\u80de\u56e0\u5b50\u7684\u4f7f\u7528\u4ee5\u53ca\u57f9\u517b\u7cfb\u7edf\u4e2d\u836f\u7406\u8c03\u8282\u5242\u7684\u6dfb\u52a0\uff09\u4ecd\u662f\u4e00\u4e2a\u4e0d\u5c0f\u7684\u6311\u6218\u3002\u5176\u6b21\uff0c\u4f18\u5316\u751f\u4ea7\u8fc7\u7a0b\u7684\u7a33\u5065\u6027\uff0c\u964d\u4f4e\u4eba\u5de5\u5de5\u4f5c\u91cf\uff0c\u540c\u65f6\u4f7f\u6c61\u67d3\u7684\u98ce\u9669\u6700\u5c0f\u5316\uff0c\u63d0\u9ad8\u5904\u7406\u80fd\u529b\uff0c\u4fc3\u8fdbT-\u7ec6\u80de\u751f\u4ea7\u7684\u6807\u51c6\u5316\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"Car-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u751f\u4ea7\u7684\u6311\u6218\u548c\u8003\u91cf\"<\/p>\n

<\/span>T-\u7ec6\u80de\u751f\u4ea7\u7684\u6311\u6218\u548c\u53ef\u80fd\u7684\u89e3\u51b3\u65b9\u6848<\/span><\/em>\uff08J.Xu, et al, 2018\uff09<\/span><\/em>
<\/span><\/p>\n

 <\/span><\/p>\n

\u81ea\u52a8\u5316\u7684\u7ec6\u80de\u751f\u4ea7<\/span><\/strong><\/p>\n

 <\/span><\/p>\n

\u8003\u8651\u5230\u81ea\u4f53T\u7ec6\u80de\u751f\u4ea7\u9700\u8981\u8017\u8d39\u76f8\u5f53\u7684\u4eba\u529b\uff0c\u4e14\u6bcf\u4e2a\u6b65\u9aa4\u9700\u8981\u591a\u4e2a\u4eea\u5668\uff0c\u52a0\u4e0a\u6602\u8d35\u7684\u8bd5\u5242\u4ee5\u53ca\u591a\u4e2a\u5f00\u653e\u5f0f\u64cd\u4f5c\u6b65\u9aa4\uff0c\u964d\u4f4e\u53ef\u80fd\u5f71\u54cd\u53ef\u91cd\u590d\u6027\u3001\u6548\u529b\u4ee5\u53ca\u5b89\u5168\u6027\u7684\u53d8\u5f02\u6027\u81f3\u5173\u91cd\u8981\u3002\u4ece\u8fd9\u65b9\u9762\u8003\u8651\uff0c\u6700\u8fd1\u5f00\u53d1\u7684\u81ea\u52a8\u5316\u7cfb\u7edf\u53ef\u80fd\u662f\u975e\u5e38\u6709\u6f5c\u529b\u7684\u89e3\u51b3\u65b9\u6848\u3002\u591a\u79cd\u534a\u81ea\u52a8\u5316\u6216\u5168\u81ea\u52a8\u5316\u7684\u8bbe\u5907\u88ab\u5f00\u53d1\u7528\u4e8e\u4e0d\u540c\u7684\u5de5\u827a\u6b65\u9aa4\uff0c\u5305\u62ec\u7528\u4e8e\u7ec6\u80de\u5206\u79bb\u3001\u7ec6\u80de\u6f02\u6d17\u4ee5\u53ca\u6d53\u7f29\u7684\u8bbe\u5907\u3002\u81ea\u52a8\u5316\u540c\u65f6\u53ef\u63d0\u4f9b\u5728\u6bcf\u4e2a\u751f\u4ea7\u6b65\u9aa4\u8fdb\u884c\u8fc7\u7a0b\u4e2d\u91c7\u6837\u4ee5\u53ca\u8d28\u91cf\u63a7\u5236\u7684\u673a\u4f1a\uff0c\u800c\u4e14\uff0c\u81ea\u52a8\u5316\u53ef\u5141\u8bb8\u5728\u751f\u4ea7\u8fc7\u7a0b\u4e2d\uff0c\u65b9\u4fbf\u5730\u8fdb\u884c\u68c0\u6d4b\u548c\u6587\u4ef6\u8bb0\u5f55\u3002\u5728\u4e0d\u4e45\u7684\u5c06\u6765\uff0c\u66f4\u591a\u81ea\u52a8\u5316\u751f\u4ea7\u8bbe\u5907\u4ee5\u53ca\u6574\u5408\u8fd9\u4e9b\u8bbe\u5907\u7684\u65b0\u5de5\u827a\u7684\u51fa\u73b0\uff0c\u53ef\u80fd\u53ef\u63d0\u4f9b\u66f4\u591a\u6807\u51c6\u5316\u7684\u7ec6\u80de\u4ea7\u54c1\uff0c\u4ee5\u652f\u6301Car-T\u7ec6\u80de\u6cbb\u7597\u7684\u4e34\u5e8a\u5e94\u7528\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u7528\u4e8eT\u7ec6\u80de\u751f\u4ea7\u7684\u57fa\u56e0\u7f16\u8f91\u6280\u672f<\/span><\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u53e6\u4e00\u79cd\u7b80\u5316T-\u7ec6\u80de\u6cbb\u7597\u7684\u65b9\u6cd5\u662f\u751f\u6210\u666e\u9002\u6027\u7684\u901a\u7528\u201c\u73b0\u8d27\u578b\u201dT\u7ec6\u80de\u4ea7\u54c1\uff0c\u7528\u4f5c\u83b7\u5f97\u6027\u7ec6\u80de\u6cbb\u7597\uff0c\u4ece\u800c\u670d\u52a1\u66f4\u5927\u7684\u60a3\u8005\u7fa4\u4f53\u3002\u65b0\u7684\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7684\u51fa\u73b0\uff0c\u5305\u62ec\u950c\u6307\u6838\u9178\u9176\uff08ZFN\uff09\u3001\u8f6c\u5f55\u6fc0\u6d3b\u5b50\u6837\u6548\u5e94\u6838\u9178\u9176\uff08TALEN\uff09\u4ee5\u53ca\u6700\u8fd1\u51fa\u73b0\u7684CRISPR\/Cas9\uff0c\u5df2\u7ecf\u4e3a\u751f\u4ea7\u5f02\u6e90\u6027\u901a\u7528\u201c\u73b0\u8d27\u201d\u5546\u54c1\u5316\u89c4\u6a21\u7ec6\u80de\u6cbb\u7597\u94fa\u5e73\u4e86\u9053\u8def\u3002\u4f7f\u7528\u201c\u73b0\u8d27\u201d\u901a\u7528\u578bT-\u7ec6\u80de\u4ea7\u54c1\uff0c\u6211\u4eec\u53ef\u4ee5\u514b\u670d\u60a3\u8005\u6765\u6e90\u7684\u7ec6\u80de\u7531\u4e8e\u8f83\u5dee\u7684\u8d28\u91cf\u3001\u4ea7\u91cf\u548c\/\u6216\u75be\u75c5\u72b6\u6001\uff0c\u800c\u4e0d\u80fd\u751f\u6210T-\u7ec6\u80de\u4ea7\u54c1\u7684\u95ee\u9898\u3002\u8fd9\u5c06\u964d\u4f4e\u751f\u4ea7\u6210\u672c\u548c\u65f6\u95f4\uff0c\u5141\u8bb8\u83b7\u5f97\u53ef\u91cd\u590d\u7684\u3001\u6709\u6548\u529b\u7684T-\u7ec6\u80de\u4ea7\u54c1\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u901a\u8fc7\u9776\u5411\u5185\u6e90\u6027\u03b1\u03b2 TCR\u548cMHC I\u7c7b\u5206\u5b50HLA\uff0c\u53ef\u964d\u4f4e\u03b1\u03b2 T\u7ec6\u80de\u4ecb\u5bfc\u7684\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75be\u75c5\uff08GVHD\uff09\u7684\u98ce\u9669\u3002\u9664\u4e86\u5f02\u6e90\u6027T\u7ec6\u80de\uff0c\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff0c\u5e72\u6270\u5185\u6e90\u6027TCR\u4e5f\u6709\u5229\u4e8e\u751f\u4ea7\u81ea\u4f53TCR-T\u7ec6\u80de\u4ea7\u54c1\uff0c\u4ee5\u964d\u4f4e\u5185\u6e90\u6027\u548c\u91cd\u7ec4TCR\u4e4b\u95f4\u7684TCR\u9519\u914d\u3002\u5982\u57fa\u4e8eCRISPR\/Cas9\u548c\u76f8\u4f3c\u7684\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5728\u5927\u89c4\u6a21T\u7ec6\u80de\u751f\u4ea7\u4e2d\u7684\u4f7f\u7528\u548c\u4f18\u5316\uff0c\u9884\u671f\u5728\u4e0d\u5c31\u7684\u5c06\u6765\uff0c\u53ef\u89c1\u5230\u666e\u9002\u6027T-\u7ec6\u80de\u4ea7\u54c1\u5728\u4e34\u5e8a\u4e2d\u4f7f\u7528\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u4e0e\u7ec6\u80de\u751f\u4ea7\u76f8\u5173\u7684\u6210\u672c<\/span><\/strong><\/p>\n

 <\/span><\/p>\n

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 <\/span><\/p>\n

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\u9884\u671f\u7684\u6cd5\u89c4\u6307\u5357<\/span><\/strong><\/p>\n

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\u5c3d\u7ba1\u76d1\u7ba1\u673a\u6784\uff0c\u5982FDA\uff0c\u591a\u5e74\u6765\u4e00\u76f4\u5728\u89c4\u8303\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\uff0c\u5e76\u5f62\u6210\u4e86\u9488\u5bf9\u4ea7\u54c1\u68c0\u6d4b\u548c\u51fa\u5382\u6807\u51c6\u7b49\u7684\u6307\u5357\u6587\u4ef6\uff0c\u4f46\u4e0d\u540c\u56fd\u5bb6\u548c\u5730\u533a\u7684\u8fd9\u4e9b\u6cd5\u89c4\u548c\u6587\u4ef6\u53ef\u80fd\u5e76\u4e0d\u5b8c\u5168\u4e00\u81f4\uff0c\u7528\u4e8e\u4e34\u5e8a\u5e94\u7528\u7684\u57fa\u56e0\u4fee\u9970\u7ec6\u80de\u4ea7\u54c1\u7684\u68c0\u6d4b\u548c\u51fa\u5382\u6210\u672c\u53ef\u80fd\u4f1a\u56e0\u4e3a\u7279\u5b9a\u76d1\u7ba1\u673a\u6784\u7684\u5173\u6ce8\u70b9\u4e0d\u540c\u800c\u6709\u5f88\u5927\u7684\u5dee\u5f02\u3002\u6240\u4ee5\uff0c\u5f53\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u65e8\u5728\u670d\u52a1\u5168\u7403\u5316\u7684\u60a3\u8005\u7fa4\u4f53\u65f6\uff0c\u4ece\u5168\u7403\u5316\u7684\u6c34\u5e73\uff0c\u6765\u534f\u8c03\u6cd5\u89c4\u8981\u6c42\uff0c\u5c06\u5728\u57fa\u4e8e\u7ec6\u80de\/\u57fa\u56e0\u6cbb\u7597\u7684\u76d1\u7ba1\u4e2d\u6807\u51c6\u5316\u6700\u4f73\u5b9e\u8df5\u4f5c\u4e3a\u76ee\u6807\uff0c\u5c06\u6781\u5927\u5730\u6709\u52a9\u4e8e\u5f62\u6210\u5b89\u5168\u3001\u9ad8\u6548\u4e14\u7ecf\u6d4e\u7684\u5e73\u53f0\u3002<\/span><\/p>\n


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 \u53c2\u8003\u539f\u6587\uff1aB.L.Levine, J.Miskin, K.Wonnacott, et al., Global manufacturing of CAR T cell therapy. Molecular therapy, 2017, 4:92-101.
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J.Xu, J.J.Melenhorst. J.A.Fraietta, Toward predision manufacturing of immunogene T-cell therapies. Cytotherpay, 2018.<\/span><\/em><\/p>\n

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\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/span><\/strong><\/span><\/p>\n

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\"Car-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u751f\u4ea7\u7684\u6311\u6218\u548c\u8003\u91cf\"<\/span><\/p>\n

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