{"id":46994,"date":"2018-09-23T01:00:00","date_gmt":"2018-09-26T01:34:55","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e6%9f%b3%e5%8f%b6%e5%88%80%ef%bc%9a%e9%98%bf%e5%a5%87%e9%9c%89%e7%b4%a0%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97%e6%94%af%e6%b0%94%e7%ae%a1%e6%89%a9%e5%bc%a0%e7%96%97%e6%95%88%e9%9d%9e%e5%8a%a3%e4%ba%8e\/"},"modified":"2018-09-26T09:34:56","modified_gmt":"2018-09-26T01:34:56","slug":"%e6%9f%b3%e5%8f%b6%e5%88%80%ef%bc%9a%e9%98%bf%e5%a5%87%e9%9c%89%e7%b4%a0%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97%e6%94%af%e6%b0%94%e7%ae%a1%e6%89%a9%e5%bc%a0%e7%96%97%e6%95%88%e9%9d%9e%e5%8a%a3%e4%ba%8e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/46994\/","title":{"rendered":"\u67f3\u53f6\u5200\uff1a\u963f\u5947\u9709\u7d20\u7528\u4e8e\u6cbb\u7597\u652f\u6c14\u7ba1\u6269\u5f20\u7597\u6548\u975e\u52a3\u4e8e\u963f\u83ab\u897f\u6797-\u514b\u62c9\u7ef4\u9178\u94be"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">\u5f15\u8a00<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u8fd1\u671f\uff0c\u77e5\u540d\u533b\u5b66\u671f\u520a\u300a\u67f3\u53f6\u5200\u300b\u4e0a\u520a\u767b\u4e86\u4e00\u5219\u963f\u83ab\u897f\u6797-\u514b\u62c9\u7ef4\u9178\u94be\u4e0e\u963f\u5947\u9709\u7d20\u6cbb\u7597\u547c\u5438\u7a98\u8feb\u5f15\u8d77\u7684\u652f\u6c14\u7ba1\u6269\u5f20\u75c7\u60a3\u513f (BEST-2)\u7684\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u975e\u52a3\u52bf\u3001\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u7ecf\u8fc721\u5929\u7684\u6cbb\u7597\uff0c\u963f\u5947\u9709\u7d20\u7528\u4e8e\u6cbb\u7597\u547c\u5438\u7a98\u8feb\u5f15\u8d77\u7684\u975e\u4e25\u91cd\u652f\u6c14\u7ba1\u6269\u5f20\u60a3\u513f\u7684\u6025\u6027\u52a0\u91cd\u671f\u4e0d\u900a\u4e8e\u963f\u83ab\u897f\u6797-\u514b\u62c9\u7ef4\u9178\u94be\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"         style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537925696.jpg\" alt=\"\u67f3\u53f6\u5200\uff1a\u963f\u5947\u9709\u7d20\u7528\u4e8e\u6cbb\u7597\u652f\u6c14\u7ba1\u6269\u5f20\u7597\u6548\u975e\u52a3\u4e8e\u963f\u83ab\u897f\u6797-\u514b\u62c9\u7ef4\u9178\u94be\" title=\"\u67f3\u53f6\u5200\uff1a\u963f\u5947\u9709\u7d20\u7528\u4e8e\u6cbb\u7597\u652f\u6c14\u7ba1\u6269\u5f20\u7597\u6548\u975e\u52a3\u4e8e\u963f\u83ab\u897f\u6797-\u514b\u62c9\u7ef4\u9178\u94be\"  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">\u5b9e\u9a8c\u80cc\u666f<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u867d\u7136\u963f\u83ab\u897f\u6797 &#8211; \u514b\u62c9\u7ef4\u9178\u76d0\u662f\u63a8\u8350\u7528\u4e8e\u652f\u6c14\u7ba1\u6269\u5f20\u60a3\u513f\u975e\u4e25\u91cd\u6025\u6027\u52a0\u91cd\u7684\u4e00\u7ebf\u7ecf\u9a8c\u6027\u53e3\u670d\u6297\u751f\u7d20\u7597\u6cd5\uff0c\u4f46\u963f\u5947\u9709\u7d20\u4e5f\u56e0\u6bcf\u65e5\u4e00\u6b21\u7ed9\u836f\u7684\u65b9\u4fbf\u6027\u88ab\u7ecf\u5e38\u4f7f\u7528\u3002\u8be5\u5b9e\u9a8c\u5047\u8bbe\u7528\u4e8e\u652f\u6c14\u7ba1\u6269\u5f20\u60a3\u513f\u7684\u6025\u6027\u52a0\u91cd\u671f\uff0c\u963f\u5947\u9709\u7d20\u4e0d\u5f31\u4e8e\u963f\u83ab\u897f\u6797-\u514b\u62c9\u7ef4\u9178\u94be\u3002\u636e\u6211\u4eec\u6240\u77e5\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u5df2\u7ecf\u53d1\u8868\u7684\u5173\u4e8e\u652f\u6c14\u7ba1\u6269\u5f20\u60a3\u513f\u6025\u6027\u52a0\u91cd\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">\u5b9e\u9a8c\u65b9\u6cd5<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u6211\u4eec\u57282012\u5e744\u6708\u81f32016\u5e748\u6708\u671f\u95f4\u5728\u6fb3\u5927\u5229\u4e9a\u548c\u65b0\u897f\u5170\u7684\u4e09\u5bb6\u533b\u9662\u8fdb\u884c\u4e86\u8fd9\u9879\u5e73\u884c\u7ec4\uff0c\u53cc\u6a21\u62df\uff0c\u53cc\u76f2\uff0c\u975e\u52a3\u6548\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002\u6211\u4eec\u62db\u52df\u4e861-19\u5c81\u7684\u9752\u5c11\u5e74\uff0c\u901a\u8fc7\u653e\u5c04\u5b66\u8bc1\u5b9e\u652f\u6c14\u7ba1\u6269\u5f20\u4e0e\u56ca\u6027\u7ea4\u7ef4\u5316\u65e0\u5173\u3002\u5728\u6076\u5316\u5f00\u59cb\u65f6\uff0c\u513f\u7ae5\u88ab\u968f\u673a\u5206\u914d\u5230\u963f\u83ab\u897f\u6797-\u514b\u62c9\u7ef4\u9178\u94be\u7ec4\uff0822.5mg \/ kg\uff0c\u6bcf\u5929\u4e24\u6b21\uff09\u548c\u5b89\u6170\u5242\u963f\u5947\u9709\u7d20\u7ec4\uff085mg \/ kg \/\u5929\uff09\uff0c\u7ed9\u836f21\u5929\u3002\u6211\u4eec\u91c7\u7528\u533a\u7ec4\u5206\u7ec4\uff08\u6309\u5e74\u9f84\uff0c\u90e8\u4f4d\u7b49\uff09\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u5728\u7ed9\u836f21\u5929\u540e\u5c06\u6076\u5316\uff08\u5b9a\u4e49\u4e3a\u56de\u5f52\u57fa\u7ebf\uff09\uff0c\u975e\u52a3\u6548\u6027\u8fb9\u9645\u4e3a-20\uff05\u3002\u6211\u4eec\u8bc4\u4f30\u4e86\u51e0\u4e2a\u6b21\u8981\u7ec8\u70b9\uff0c\u5305\u62ec\u6076\u5316\u7684\u6301\u7eed\u65f6\u95f4\uff0c\u4e0b\u6b21\u6076\u5316\u7684\u65f6\u95f4\uff0c\u5b9e\u9a8c\u5ba4\uff0c\u547c\u5438\u9053\u548c\u751f\u6d3b\u8d28\u91cf\u7684\u6d4b\u91cf\uff0c\u4ee5\u53ca\u5fae\u751f\u7269\u5b66\u3002\u8be5\u8bd5\u9a8c\u5df2\u5728\u6fb3\u5927\u5229\u4e9a\/\u65b0\u897f\u5170\u6ce8\u518c\u5904\uff08ACTRN12612000010897\uff09\u6ce8\u518c\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">\u5b9e\u9a8c\u7ed3\u679c<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u6211\u4eec\u7b5b\u9009\u4e86604\u540d\u513f\u7ae5\u5e76\u62db\u52df\u4e86236\u540d\u513f\u7ae5\uff0c179\u540d\u513f\u7ae5\u60a3\u6709\u6025\u6027\u53d1\u4f5c\u5e76\u88ab\u5206\u914d\u5230\u6cbb\u7597\u7ec4\uff1a97\u540d\u5206\u914d\u5230\u963f\u83ab\u897f\u6797-\u514b\u62c9\u7ef4\u9178\u94be\u7ec4\uff0c82\u540d\u5206\u914d\u5230\u963f\u5947\u9709\u7d20\u7ec4\u3002\u5230\u7b2c21\u5929\u65f6\uff0c\u963f\u5947\u9709\u7d20\u7ec4\u4e2d73\u4f8b\u6025\u6027\u52a0\u91cd\u7ec4\u4e2d\u670961\u4f8b\uff0884\uff05\uff09\u6d88\u9000\u4e86\uff0c\u800c\u963f\u83ab\u897f\u6797 &#8211; \u514b\u62c9\u7ef4\u9178\u7ec4\u4e2d\u670987\u4f8b\uff0884\uff05\uff09\u6d88\u9000\u4e86\uff0c\u98ce\u9669\u5dee\u5f02\u663e\u793a\u975e\u52a3\u6548\u6027\uff08-0.3\uff05\uff0c95\uff05CI -11.8\u81f311.1\uff09\u3002\u963f\u83ab\u897f\u6797-\u514b\u62c9\u7ef4\u9178\u94be\u7ec4\u7684\u6025\u6027\u53d1\u4f5c\u660e\u663e\u77ed\u4e8e\u963f\u5947\u9709\u7d20\u7ec4\uff08\u4e2d\u4f4d\u657010\u5929[IQR 6-15]\u5bf9\u6bd414\u5929[8-16];p=0.014\uff09\u3002\u963f\u5947\u9709\u7d20\u7ec482\u540d\u513f\u7ae5\u4e2d17\u540d\uff0821\uff05\uff09\u7684\u8bd5\u9a8c\u836f\u7269\u4e0d\u826f\u4e8b\u4ef6\u4e0e\u963f\u83ab\u897f\u6797-\u514b\u62c9\u7ef4\u9178\u7ec497\u540d\u60a3\u8005\u4e2d\u768423\u540d\uff0824\uff05\uff09\u76f8\u5173\uff08\u76f8\u5bf9\u98ce\u96690.9,95\uff05CI 0.5\u6bd41.5\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">\u5b9e\u9a8c\u8ba8\u8bba<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u7ecf\u8fc721\u5929\u7684\u6cbb\u7597\uff0c\u963f\u5947\u9709\u7d20\u7528\u4e8e\u6cbb\u7597\u547c\u5438\u7a98\u8feb\u5f15\u8d77\u7684\u975e\u4e25\u91cd\u652f\u6c14\u7ba1\u6269\u5f20\u60a3\u513f\u7684\u6025\u6027\u52a0\u91cd\u671f\u4e0d\u900a\u4e8e\u963f\u83ab\u897f\u6797-\u514b\u62c9\u7ef4\u9178\u94be\u3002 \u5728\u4e00\u4e9b\u60a3\u8005\u4e2d\uff0c\u4f8b\u5982\u9752\u9709\u7d20\u8fc7\u654f\u75c7\u60a3\u8005\u6216\u90a3\u4e9b\u53ef\u80fd\u5177\u6709\u8f83\u5dee\u4f9d\u4ece\u6027\u7684\u60a3\u8005\u6765\u8bf4\uff0c\u963f\u5947\u9709\u7d20\u4e3a\u6076\u5316\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u53e6\u4e00\u79cd\u9009\u62e9\uff0c\u4f46\u5fc5\u987b\u4e0e\u6cbb\u7597\u5931\u8d25\u7684\u98ce\u9669\uff08\u572820\uff05\u7684\u8303\u56f4\u5185\uff09\u3001\u66f4\u957f\u7684\u6076\u5316\u6301\u7eed\u65f6\u95f4\u548c\u8bf1\u5bfc\u5927\u73af\u5185\u916f\u6297\u6027\u98ce\u9669\u76f8\u5e73\u8861\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">Purch<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">ase one-time access<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">1.Amoxicillin\u2013clavulanate versus azithromycin for respiratoryexacerbations in children with bronchiectasis (BEST-2): a multicentre,double-blind, non-inferiority, randomised controlled trial<\/span><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;word-wrap: break-word !important;\">\n<section style=\"margin-right: 3px;margin-left: 3px;padding: 20px;max-width: 677px;box-sizing: border-box;word-wrap: break-word;background-color: rgb(254, 254, 254);border-color: rgb(210, 150, 20);box-shadow: rgb(210, 150, 20) 0px 0px 4px;\">\n<p style=\"max-width: 631px;box-sizing: border-box;word-wrap: break-word;min-height: 18px;color: rgb(210, 150, 20);font-size: 18px;font-weight: 700;min-width: 1px;\">\u57f9\u8bad\u548c\u4f1a\u8bae\uff1a<\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 593.6px;box-sizing: border-box;word-wrap: break-word;min-height: 17px;color: rgb(6, 6, 6);letter-spacing: 0.54px;\"><span style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;font-size: 15px;\">\u540c\u5199\u610f\u57f9\u8bad<\/span><\/p>\n<\/li>\n<\/ul>\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 631px;box-sizing: border-box;word-wrap: break-word;border-color: rgb(210, 150, 20);\">\n<h2 class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650624081&amp;idx=1&amp;sn=c5f77cee20dc1335acc21f30ad489921&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5199\u610f\u5de8\u732e\u4e2830\u4f4d\u4e13\u5bb6\u8bba\u9053\u4e0a\u6d77\u6ee9\uff1a\u65b0\u836f\u4e2d\u7f8e\u53cc\u62a5\u4e4b\u4e34\u5e8a\u7814\u7a76\u5cf0\u4f1a<\/a><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<hr style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"  \/>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: center;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<hr style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"  \/>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;white-space: 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