{"id":47021,"date":"2018-09-21T01:00:00","date_gmt":"2018-09-26T01:35:15","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e9%82%a3%e4%ba%9b%e5%85%b7%e6%9c%89%e8%87%b4%e7%99%8c%e4%bd%9c%e7%94%a8%e7%9a%84%e9%87%8d%e7%a3%85%e8%8d%af%e7%89%a9\/"},"modified":"2018-09-26T09:35:16","modified_gmt":"2018-09-26T01:35:16","slug":"%e9%82%a3%e4%ba%9b%e5%85%b7%e6%9c%89%e8%87%b4%e7%99%8c%e4%bd%9c%e7%94%a8%e7%9a%84%e9%87%8d%e7%a3%85%e8%8d%af%e7%89%a9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/47021\/","title":{"rendered":"\u90a3\u4e9b\u5177\u6709\u201c\u81f4\u764c\u201d\u4f5c\u7528\u7684\u91cd\u78c5\u836f\u7269"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"max-width: 100%;box-sizing: border-box;font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;width: 50px;height: 50px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 1px;border-radius: 50%;border-color: rgb(62, 62, 62) rgba(255, 255, 255, 0) rgb(62, 62, 62) rgb(62, 62, 62);box-shadow: rgb(0, 0, 0) 0px 0px 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 15px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: right;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;font-size: 15px;\"><span style=\"color:#ff0000;\"><strong>\u6458\u8981&nbsp;<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;float: left;width: 20px;height: 20px;overflow: hidden;word-wrap: break-word !important;\">\n<section style=\"margin-top: -10px;margin-left: -10px;max-width: 100%;box-sizing: border-box;width: 20px;height: 20px;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(161, 231, 112);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;float: right;width: 20px;height: 20px;overflow: hidden;word-wrap: break-word !important;\">\n<section style=\"margin-top: -10px;margin-right: -10px;max-width: 100%;box-sizing: border-box;float: right;width: 20px;height: 20px;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(161, 231, 112);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;height: 10px;border-top: 1px solid rgb(161, 231, 112);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"padding-right: 20px;padding-left: 20px;max-width: 100%;box-sizing: border-box;border-left: 1px solid rgb(161, 231, 112);border-right: 1px solid rgb(161, 231, 112);border-top-color: rgb(161, 231, 112);border-bottom-color: rgb(161, 231, 112);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;font-size: 15px;word-wrap: break-word !important;\">\n<p>\u672c\u6587\u4e3b\u8981\u8bb2\u8ff0\u4e86\u5229\u57f9\u916e\u3001GLP-1\u6fc0\u52a8\u5242\u7c7b\u836f\u7269\u548c\u7279\u7acb\u5e15\u80bd\u7684\u81f4\u764c\u6027\u5b9e\u9a8c\u7ed3\u679c\u3002\u901a\u8fc7\u5b9e\u4f8b\u5c55\u793a\u81f4\u764c\u6027\u5b9e\u9a8c\u7ed3\u679c\u89e3\u8bfb\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;float: left;width: 20px;height: 10px;overflow: hidden;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: -10px;margin-left: -10px;max-width: 100%;box-sizing: border-box;width: 20px;height: 20px;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(161, 231, 112);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;float: right;width: 20px;height: 10px;overflow: hidden;word-wrap: break-word !important;\">\n<section style=\"margin-right: -10px;margin-bottom: -10px;max-width: 100%;box-sizing: border-box;float: right;width: 20px;height: 20px;border-radius: 50%;border-width: 1px;border-style: solid;border-color: rgb(161, 231, 112);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;height: 10px;border-bottom: 1px solid rgb(161, 231, 112);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align:justify;text-justify:inter-ideograph;\"><br  \/><\/p>\n<p style=\"text-align: justify;\">\u56fd\u9645\u4e0a\uff0c\u5bf9\u4e8e\u9884\u671f\u957f\u671f\u4f7f\u7528\u7684\u836f\u7269\u5df2\u7ecf\u8981\u6c42\u8fdb\u884c\u556e\u9f7f\u7c7b\u52a8\u7269\u81f4\u764c\u8bd5\u9a8c\u3002\u5728\u7f8e\u56fd\uff0c\u5927\u591a\u6570\u836f\u7269\u5728\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4eba\u4f53\u4e4b\u524d\uff0c\u5df2\u8fdb\u884c\u4e86\u52a8\u7269\u81f4\u764c\u8bd5\u9a8c\u3002<span style=\"color: rgb(255, 76, 0);\">\u6839\u636eFDA\u8981\u6c42\uff0c\u4e00\u822c\u836f\u7269\u4f7f\u75283\u4e2a\u6708\u6216\u66f4\u957f\u65f6\u95f4\uff0c\u9700\u8981\u8fdb\u884c\u81f4\u764c\u8bd5\u9a8c\u3002<\/span>\u5728\u6b27\u6d32\uff0c\u201c\u6b27\u5171\u4f53\u836f\u54c1\u7ba1\u7406\u6761\u4f8b\u201d\u89c4\u5b9a\u4e86\u9700\u8981\u8fdb\u884c\u81f4\u764c\u8bd5\u9a8c\u7684\u60c5\u51b5\uff0c\u5305\u62ec\u957f\u671f\u5e94\u7528\u7684\u836f\u7269\uff0c\u5373\u81f3\u5c116\u4e2a\u6708\u7684\u8fde\u7eed\u7528\u836f\uff0c\u6216\u9891\u7e41\u7684\u95f4\u6b47\u6027\u7528\u836f\u4ee5\u81f4\u603b\u7684\u66b4\u9732\u91cf\u4e0e\u524d\u8005\u76f8\u4f3c\u7684\u836f\u7269\u3002<\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u65e5\u672c\uff0c<span style=\"color: rgb(255, 76, 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0);\">CFDA\u4e0eICH\u7684\u8981\u6c42\u4e00\u81f4\uff0c\u5bf9\u9884\u671f\u4e34\u5e8a\u7528\u836f\u671f\u81f3\u5c11\u8fde\u7eed6\u4e2a\u6708\u7684\u836f\u7269\u4e00\u822c\u5e94\u8fdb\u884c\u81f4\u764c\u8bd5\u9a8c\u3002<\/span>\u5927\u591a\u6570\u7597\u7a0b\u4e3a3\u4e2a\u6708\u7684\u836f\u7269\u901a\u5e38\u4e0d\u4f1a\u4ec5\u7528\u52303\u4e2a\u6708\uff0c\u53ef\u80fd\u8fde\u7eed\u7528\u836f\u8fbe6\u4e2a\u6708\u3002\u67d0\u4e9b\u7c7b\u578b\u7684\u5316\u5408\u7269\u53ef\u80fd\u4e0d\u4f1a\u8fde\u7eed\u7528\u836f\u8fbe6\u4e2a\u6708\uff0c\u4f46\u53ef\u80fd\u4ee5\u95f4\u6b47\u7684\u65b9\u5f0f\u91cd\u590d\u4f7f\u7528\u3002<\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\">\u6cbb\u7597\u6162\u6027\u548c\u590d\u53d1\u6027\u75be\u75c5\uff08\u5305\u62ec\u8fc7\u654f\u6027\u9f3b\u708e\u3001\u6291\u90c1\u75c7\u548c\u7126\u8651\u75c7\uff09\uff0c\u800c\u9700\u7ecf\u5e38\u95f4\u6b47\u4f7f\u7528\u7684\u836f\u7269\uff0c\u4e00\u822c\u4e5f\u9700\u8fdb\u884c\u81f4\u764c\u8bd5\u9a8c\u3002\u67d0\u4e9b\u53ef\u80fd\u5bfc\u81f4\u66b4\u9732\u65f6\u95f4\u5ef6\u957f\u7684\u91ca\u836f\u7cfb\u7edf\uff0c\u4e5f\u5e94\u8003\u8651\u8fdb\u884c\u81f4\u764c\u8bd5\u9a8c\u3002<span style=\"color: rgb(255, 76, 0);\">\u81f4\u764c\u5b9e\u9a8c\u901a\u5e38\u9700\u5728\u4e0a\u5e02\u7533\u8bf7\u524d\u5b8c\u6210\u3002<\/span>\u5982\u679c\u81f4\u764c\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\u836f\u7269\u5177\u6709\u81f4\u764c\u4f5c\u7528\u6216\u589e\u52a0\u764c\u75c7\u7684\u98ce\u9669\uff0c\u90a3\u8be5\u5982\u4f55\u770b\u5f85\u6b64\u5b9e\u9a8c\u7ed3\u679c\uff0c<span style=\"color: rgb(255, 76, 0);\">\u8be5\u836f\u8fd8\u80fd\u5426\u83b7\u6279\u4e0a\u5e02\u5462\uff1f\u4e0b\u9762\u5c31\u4ecb\u7ecd\u51e0\u79cd\u5bf9\u52a8\u7269\u5177\u6709\u81f4\u764c\u4f5c\u7528\u7684\u836f\u7269\uff0c<\/span><span style=\"color: rgb(0, 0, 0);\">\u4e00\u8d77\u5b66\u4e60\u5927\u836f\u4f01\u662f\u5982\u4f55\u5206\u6790\u53ca\u8bc4\u4f30\u98ce\u9669\u7684\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"padding: 3px;max-width: 100%;box-sizing: border-box;display: inline-block;background-color: rgb(249, 110, 87);word-wrap: break-word !important;\">\n<section style=\"padding: 2px 8px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: dotted;border-color: rgb(255, 255, 255);color: rgb(255, 255, 255);line-height: 1.4em;font-size: 14px;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u6848\u4f8b1\uff1a\u5229\u57f9\u916e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;font-size: 14px;color: rgb(5, 5, 5);line-height: 1.5;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;\">\u5229\u57f9\u916e\u4e3a\u6297\u7cbe\u795e\u5206\u88c2\u7684\u7ecf\u5178\u8001\u836f\uff0c<span style=\"color: rgb(255, 76, 0);\">\u8be5\u836f\u6700\u65e9\u4e8e 1992 \u5e74\u5728\u82f1\u56fd\u4e0a\u5e02\uff0c1993 \u5e74\u767b\u9646\u7f8e\u56fd\u3002<\/span>\u4e0e\u7b2c\u4e00\u4ee3\u6297\u7cbe\u795e\u5206\u88c2\u836f\u76f8\u6bd4\uff0c\u5176\u6781\u5c11\u7684\u690e\u4f53\u5916\u7cfb\u53cd\u5e94\u53ca\u826f\u597d\u7684\u7597\u6548\u4f7f\u5176\u7a33\u5c45\u4e00\u7ebf\u7528\u836f\u5730\u4f4d\uff0c\u4e5f\u662f\u8be5\u836f\u5960\u5b9a\u4e86\u5f3a\u751f\u5728 CNS \u9886\u57df\u5168\u7403\u9886\u5934\u7f8a\u7684\u5730\u4f4d\u3002<span style=\"color: rgb(255, 76, 0);\">\u5229\u57f9\u916e\u7cfb\u5217\u4ea7\u54c1\u7684\u9500\u552e\u989d\u5df2\u9ad8\u8fbe500\u591a\u4ebf\u7f8e\u91d1\uff0c<\/span>\u5927\u5bb6\u5bf9\u8be5\u7cfb\u5217\u4ea7\u54c1\u5347\u7ea7\u6539\u9020\u7684\u6545\u4e8b\u4e5f\u662f\u6d25\u6d25\u4e50\u9053\u3002\u5982\u6b64\u7545\u9500\u7684\u836f\u7269\uff0c\u836f\u54c1\u8bf4\u660e\u4e66\u663e\u793a\u5176\u5bf9\u5927\u9f20\u548c\u5c0f\u9f20\u4e5f\u662f\u6709\u81f4\u764c\u4f5c\u7528\u7684\u3002<\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\">\u4ee50.63 mg\/kg\u30012.5 mg\/kg\u300110 mg\/kg&nbsp;\u8fde\u7eed\u63ba\u98df\u7ed9\u836fSwiss albino&nbsp;\u5c0f\u9f2018\u4e2a\u6708\u6216Wistar&nbsp;\u5927\u9f2025\u4e2a\u6708\uff0c\u6309\u4f53\u91cd\u6298\u7b97\uff0c\u76f8\u5f53\u4e8e\u6700\u5927\u4e34\u5e8a\u63a8\u8350\u5242\u91cf(16mg,qd)\u76842.4\u30019.4\u548c&nbsp;37.5&nbsp;\u500d\uff0c\u6309\u4f53\u8868\u9762\u79ef\u6cd5\u6298\u7b97\uff0c\u5219\u76f8\u5f53\u4e8e\u6700\u5927\u4e34\u5e8a\u63a8\u8350\u5242\u91cf\u76840.2\u30010.75\u30013&nbsp;\u500d\uff08\u5c0f\u9f20\uff09\u62160.4\u30011.5\u30016 \u500d\uff08\u5927\u9f20\uff09\u3002<span style=\"color: rgb(255, 76, 0);\">\u81f4\u764c\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\u7ed9\u836f\u7ec4\u8111\u5782\u4f53\u817a\u7624\u3001\u5185\u5206\u6ccc\u80f0\u817a\u7624\u548c\u4e73\u817a\u764c\u7684\u53d1\u751f\u7387\u663e\u8457\u589e\u52a0\uff0c<\/span>\u4e14\u6309\u7167\u4f53\u8868\u9762\u79ef\u6cd5\u6700\u4f4e\u81f4\u764c\u5242\u91cf\u53ea\u76f8\u5f53\u4e8e\u4e34\u5e8a\u6700\u5927\u63a8\u8350\u5242\u91cf\u76840.2~6\u500d\u3002<\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\">\u5229\u57f9\u916e\u5fae\u7403\u6bcf\u4e24\u5468\u4e00\u6b21\u3001\u6bcf\u6b21\u808c\u8089\u6ce8\u5c045 mg\/kg\u621640 mg\/kg\uff08\u4ee5\u5229\u57f9\u916e\u8ba1\uff09\uff0c\u8fde\u7eed\u7ed9\u4e88Wistar&nbsp;\u5927\u9f2024\u4e2a\u6708\uff0c<span style=\"color: rgb(255, 76, 0);\">\u6309\u4f53\u8868\u9762\u79ef\u6298\u7b97\uff0c\u76f8\u5f53\u4e8e\u6700\u5927\u4e34\u5e8a\u63a8\u8350\u5242\u91cf\uff0850mg\uff09\u76841\u500d\u548c8\u500d\u3002<\/span>\u4e34\u5e8a\u7ed9\u836f50mg\u540e\uff0c\u4eba\u4f53\u8840\u6d46\u66b4\u9732\u91cf\u5206\u522b\u662f\u5927\u9f20\u7ed9\u836f5 mg\/kg\u548c40 mg\/kg\u540e\u5176\u8840\u6d46\u66b4\u9732\u91cf\u76840.3\u548c2\u500d<span style=\"color: rgb(0, 0, 0);\">\u3002<\/span><span style=\"color: rgb(255, 76, 0);\">\u81f4\u764c\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a<\/span>\u572840mg\/kg\u7ed9\u836f\u7ec4\uff0c\u96cc\u96c4\u5927\u9f20\u8111\u5782\u4f53\u817a\u7624\u3001\u5185\u5206\u6ccc\u80f0\u817a\u7624\u548c\u80be\u4e0a\u817a\u9ad3\u8d28\u55dc\u94ec\u7ec6\u80de\u7624\u7684\u53d1\u751f\u7387\u663e\u8457\u589e\u52a0\uff0c\u96c4\u6027\u5927\u9f20\u80be\u5c0f\u7ba1\u817a\u7624\u548c\u817a\u764c\u7684\u53d1\u751f\u7387\u663e\u8457\u589e\u52a0\uff1b<span style=\"color: rgb(255, 76, 0);\">\u800c\u5728\u4f4e\u3001\u9ad8\u4e24\u4e2a\u7ed9\u836f\u7ec4\uff0c\u96cc\u6027\u5927\u9f20\u4e73\u817a\u764c\u53d1\u751f\u7387\u663e\u8457\u589e\u52a0\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\">\u7814\u7a76\u7ed3\u679c\u663e\u793a\u591a\u5df4\u80faD2\u53d7\u4f53\u62ee\u6297\u5242\u53ef\u4ee5\u7f13\u6162\u4e0a\u8c03\u556e\u9f7f\u7c7b\u52a8\u7269\u7684\u50ac\u4e73\u7d20\u6c34\u5e73\u3002<span style=\"color: rgb(255, 76, 0);\">\u5728\u53e3\u670d\u81f4\u764c\u5b9e\u9a8c\u7684\u7ed9\u836f\u5242\u91cf\u4e0b\uff0c\u5c0f\u9f20\u548c\u5927\u9f20\u7684\u50ac\u4e73\u7d20\u6c34\u5e73\u4e0a\u8c03\u4e865~6\u500d\u3002<\/span>\u5728\u808c\u8089\u6ce8\u5c04\u7684\u81f4\u764c\u5b9e\u9a8c\u4e2d\uff0c\u96cc\u96c4\u5927\u9f20\u50ac\u4e73\u7d20\u7684\u4e0a\u8c03\u5177\u6709\u4f9d\u8d56\u6027\uff0c\u5206\u522b\u4e0a\u8c03\u4e861.5\u500d\u548c6\u500d\u3002<\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\">\u5176\u4ed6\u6297\u7cbe\u795e\u75c5\u7c7b\u836f\u7269\u7684\u81f4\u764c\u5b9e\u9a8c\u4e2d\u4e5f\u540c\u6837\u53d1\u73b0\u556e\u9f7f\u7c7b\u52a8\u7269\u8111\u5782\u4f53\u817a\u7624\u3001\u5185\u5206\u6ccc\u80f0\u817a\u7624\u548c\u4e73\u817a\u764c\u7684\u53d1\u751f\u53ef\u80fd\u662f\u50ac\u4e73\u7d20\u4e0a\u8c03\u4ecb\u5bfc\u7684\u3002\u7136\u800c\uff0c<span style=\"color: rgb(255, 76, 0);\">\u65e2\u6ca1\u6709\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u6ca1\u6709\u6d41\u884c\u75c5\u5b66\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u957f\u671f\u670d\u7528\u8fd9\u7c7b\u6297\u7cbe\u795e\u75c5\u836f\u7269\u4e0e\u80bf\u7624\u53d1\u751f\u7387\u76f8\u5173\u3002<\/span><\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: center;\">\u88681. \u5229\u57f9\u916e\u7cfb\u5217\u4ea7\u54c1<\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537925715.jpg\" alt=\"\u90a3\u4e9b\u5177\u6709\u201c\u81f4\u764c\u201d\u4f5c\u7528\u7684\u91cd\u78c5\u836f\u7269\" title=\"\u90a3\u4e9b\u5177\u6709\u201c\u81f4\u764c\u201d\u4f5c\u7528\u7684\u91cd\u78c5\u836f\u7269\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family:\u5b8b\u4f53;color:rgb(12,12,12);font-size:16px;\">&nbsp;<\/span><br  \/><\/p>\n<p style=\"text-align: center;\">\u88682. \u5229\u57f9\u916e\u81f4\u764c\u5b9e\u9a8c\u7ed3\u679c<\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;\"><span style=\"font-family:Calibri;color:rgb(12,12,12);font-size:14px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;\"><span style=\"font-family:\u5b8b\u4f53;color:rgb(12,12,12);font-size:14px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537925715.jpg\" alt=\"\u90a3\u4e9b\u5177\u6709\u201c\u81f4\u764c\u201d\u4f5c\u7528\u7684\u91cd\u78c5\u836f\u7269\" title=\"\u90a3\u4e9b\u5177\u6709\u201c\u81f4\u764c\u201d\u4f5c\u7528\u7684\u91cd\u78c5\u836f\u7269\"  \/><\/p>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"padding: 3px;max-width: 100%;box-sizing: border-box;display: inline-block;background-color: rgb(249, 110, 87);word-wrap: break-word !important;\">\n<section style=\"padding: 2px 8px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: dotted;border-color: rgb(255, 255, 255);color: rgb(255, 255, 255);line-height: 1.4em;font-size: 14px;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u6848\u4f8b2\uff1aGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u76ee\u524d\u5168\u7403\u5df2\u4e0a\u5e02\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u51717\u4e2a\uff0c\u5176\u4e2d\u5e74\u9500\u552e\u6700\u5927\u7684\u662f\u5229\u62c9\u9c81\u80bd\uff0c\u9ad8\u8fbe30\u4ebf\u7f8e\u91d1\u3002<span style=\"color: rgb(255, 76, 0);\">GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u4e0d\u4f46\u5177\u6709\u663e\u8457\u7684\u964d\u7cd6\u7597\u6548\uff0c\u540c\u65f6\u517c\u6709\u4f4e\u8840\u7cd6\u53d1\u751f\u7387\u4f4e\u7684\u4f18\u70b9\u3002<\/span>\u6b64\u5916\uff0c\u6b64\u7c7b\u836f\u7269\u8fd8\u80fd\u964d\u4f4e\u4f53\u91cd\u3001\u964d\u4f4e\u6536\u7f29\u538b\u548c\u6539\u5584\u8840\u8102\u7d0a\u4e71\uff0c\u90e8\u5206\u836f\u7269\u8fd8\u53ef\u51cf\u5c11\u5fc3\u8840\u7ba1\u4e8b\u4ef6\uff0c\u4f46\u662f\u8fd9\u7c7b\u836f\u7269\u4e5f\u6709\u4e00\u4e9b\u5171\u540c\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u8bf4\u660e\u4e66\u4e2d\u5747\u589e\u52a0\u4e86\u9ed1\u6846\u8b66\u544a\u3002\u4e0b\u9762\u5c31\u4ee5\u5229\u62c9\u9c81\u80bd\u4e3a\u4f8b\uff0c\u4ecb\u7ecd\u8be5\u7c7b\u836f\u7269\u7684\u81f4\u764c\u98ce\u9669\u3002<\/p>\n<p style=\"text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:150%;\"><span style=\"font-family: \u5b8b\u4f53;line-height: 150%;color: rgb(12, 12, 12);letter-spacing: 0;font-size: 16px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537925715-1.jpg\" alt=\"\u90a3\u4e9b\u5177\u6709\u201c\u81f4\u764c\u201d\u4f5c\u7528\u7684\u91cd\u78c5\u836f\u7269\" title=\"\u90a3\u4e9b\u5177\u6709\u201c\u81f4\u764c\u201d\u4f5c\u7528\u7684\u91cd\u78c5\u836f\u7269\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:150%;\"><span style=\"font-family:Calibri;line-height:150%;color:rgb(12,12,12);font-size:16px;\">&nbsp;<\/span><br  \/><\/p>\n<p style=\"text-align: center;\">\u56fe1. \u5229\u62c9\u9c81\u80bd\u9ed1\u6846\u8b66\u544a<\/p>\n<p style=\"text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:150%;\"><span style=\"font-family:Calibri;line-height:150%;color:rgb(12,12,12);font-size:16px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;\">\u5728\u96c4\u6027\u548c\u96cc\u6027CD-1\u5c0f\u9f20\u8fdb\u884c\u4e00\u9879104-\u5468\u81f4\u764c\u6027\u7814\u7a76\uff0c\u5229\u62c9\u9c81\u80bd\u901a\u8fc7\u63a8\u6ce8\u76ae\u4e0b\u7ed9\u836f0.03\u30010.2\u30011\u548c3 mg\/kg\/day\uff0c<span style=\"color: rgb(255, 76, 0);\">\u5176<\/span><span style=\"color: rgb(255, 76, 0);\">\u4ea7\u751f\u7684\u7cfb\u7edf\u66b4\u9732\u4e3a\u6700\u5927\u63a8\u8350\u4e34\u5e8a\u5242\u91cf(MRHD)1.8&nbsp;mg\/day\u4e0b\u66b4\u9732\u91cf\u76840.2\u30012\u300110\u548c45\u500d\u3002<\/span>1\u548c3 mg\/kg\/day\u7ec4\u7684\u7ed3\u679c\u663e\u793a\u826f\u6027\u7532\u72b6\u817aC-\u7ec6\u80de\u817a\u7624\u5242\u91cf\u76f8\u5173\u6027\u589e\u52a0\uff0c\u96c4\u6027\u5c0f\u9f20\u53d1\u751f\u738713%\u548c19%\uff0c\u800c\u96cc\u6027\u5c0f\u9f20\u53d1\u751f\u7387\u4e3a6%\u548c20%\u3002<\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u5bf9\u7167\u7ec4\u548c0.03\u53ca0.2 mg\/kg\/day\u7ec4\u5747\u672a\u53d1\u751fC-\u7ec6\u80de\u817a\u7624\u3002\u57283 mg\/kg\/day\u7ec4\uff0c\u96cc\u6027\u5c0f\u9f20\u6076\u6027C-\u7ec6\u80de\u764c\u7684\u53d1\u751f\u7387\u4e3a3%\u3002<span style=\"color: rgb(255, 76, 0);\">\u5728\u5c0f\u9f20\u81f4\u764c\u6027\u5b9e\u9a8c\u671f\u95f4\u7532\u72b6\u817aC\u7ec6\u80de\u7624\u662f\u7f55\u89c1\u7684\u3002<\/span>\u57283 mg\/kg\/day\u7ec4\uff0c\u96c4\u6027\u5927\u9f20\u80cc\u90e8\u76ae\u80a4\u548c\u76ae\u4e0b\u7ec4\u7ec7\u7684\u7ea4\u7ef4\u8089\u7624\u53d1\u751f\u7387\u663e\u8457\u589e\u52a0\uff0c\u8fd9\u4e9b\u7ea4\u7ef4\u8089\u7624\u662f\u6ce8\u5c04\u90e8\u4f4d\u5c40\u90e8\u836f\u7269\u6d53\u5ea6\u9ad8\u5bfc\u81f4\u7684\u3002\u4e34\u5e8a\u5236\u5242\u6d53\u5ea6(6 mg\/mL)\u662f\u5c0f\u9f20\u81f4\u764c\u6027\u5b9e\u9a8c\u5236\u5242\u6d53\u5ea6(0.6 mg\/mL)\u768410\u500d\u3002<\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u96c4\u6027\u548c\u96cc\u6027SD\u5927\u9f20\u8fdb\u884c\u4e00\u9879104-\u5468\u81f4\u764c\u6027\u7814\u7a76\uff0c\u5229\u62c9\u9c81\u80bd\u901a\u8fc7\u63a8\u6ce8\u76ae\u4e0b\u7ed9\u836f0.075\u30010.25\u548c0.75 mg\/kg\/day\uff0c<span style=\"color: rgb(255, 76, 0);\">\u5176\u4ea7\u751f\u7684\u7cfb\u7edf\u66b4\u9732\u4e3a\u6700\u5927\u63a8\u8350\u4e34\u5e8a\u5242\u91cf(MRHD)1.8&nbsp;mg\/day\u4e0b\u66b4\u9732\u91cf\u76840.5\u30012\u548c8\u500d\u3002<\/span>\u57280(\u5bf9\u7167)\u30010.075\u30010.25\u548c0.75 mg\/kg\/day\u7ec4\uff0c\u96c4\u6027\u5927\u9f20\u826f\u6027\u7532\u72b6\u817aC-\u7ec6\u80de\u817a\u7624\u53d1\u751f\u7387\u5206\u522b12%\u300116%\u300142%\u548c46%\uff0c\u96cc\u6027\u5927\u9f20\u53d1\u751f\u7387\u5206\u522b10%\u300127%\u300133%\u548c56%\uff1b\u96c4\u6027\u5927\u9f20\u6076\u6027\u7532\u72b6\u817aC-\u7ec6\u80de\u764c\u53d1\u751f\u7387\u5206\u522b\u4e3a2%\u30018%\u30016%\u548c14%\uff0c<span style=\"color: rgb(255, 76, 0);\">\u96cc\u6027\u4e3a0%\u30010%\u30014%\u548c6%\u3002<\/span>\u5728\u5927\u9f20\u81f4\u764c\u6027\u5b9e\u9a8c\u4e2d\u7532\u72b6\u817aC-\u7ec6\u80de\u764c\u662f\u7f55\u89c1\u7684\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: rgb(255, 76, 0);\">\u5c0f\u9f20\u7814\u7a76\u7ed3\u679c\u8868\u660e<\/span>\u5229\u62c9\u9c81\u80bd\u8bf1\u5bfcC-\u7ec6\u80de\u589e\u6b96\u4f9d\u8d56\u4e8eGLP-1\u53d7\u4f53\uff0c\u4e0d\u4f1a\u5bfc\u81f4C\u7ec6\u80de\u539f\u764c\u57fa\u56e0\u5728\u8f6c\u67d3\u8fc7\u7a0b\u4e2d\u91cd\u65b0\u6fc0\u6d3b\u3002<\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: rgb(255, 76, 0);\">\u4eba\u4e0e\u5c0f\u9f20\u548c\u5927\u9f20\u7532\u72b6\u817aC\u7ec6\u80de\u80bf\u7624\u7684\u76f8\u5173\u6027\u5c1a\u4e0d\u6e05\u695a<\/span>\uff0c\u4e5f\u65e0\u6cd5\u901a\u8fc7\u4e34\u5e8a\u6216\u975e\u4e34\u5e8a\u5b9e\u9a8c\u8fdb\u884c\u786e\u5b9a\u3002<\/p>\n<p style=\"margin-left: 0;text-indent: 0;padding: 0;line-height: 150%;\"><strong><span style=\"color: rgb(12, 12, 12);letter-spacing: 0px;font-weight: bold;font-style: normal;font-size: 16px;font-family: \u5b8b\u4f53;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: rgb(255, 76, 0);\">\u57fa\u4e8e\u5c0f\u9f20\u548c\u5927\u9f20\u81f4\u764c\u6027\u5b9e\u9a8c\u7ed3\u679c\uff0c<\/span>FDA\u8981\u6c42\u8be5\u7c7b\u836f\u7269\u589e\u52a0\u76f8\u5e94\u7684\u9ed1\u6846\u8b66\u544a\uff0c\u5e76\u4e14\u7981\u6b62\u7532\u72b6\u817a\u9ad3\u8d28\u764c\uff08MTC\uff09\u60a3\u8005\u6216\u9ad8\u5371\u4eba\u7fa4\u4ee5\u53ca\u591a\u53d1\u6027\u5185\u5206\u6ccc\u817a\u7624\u7efc\u5408\u5f812\u578b\uff08MEN2\uff09\u60a3\u8005\u4f7f\u7528GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u3002<\/p>\n<p style=\"margin-left: 0;text-indent: 0;padding: 0;line-height: 150%;\"><span style=\"line-height: 150%;color: rgb(255, 0, 0);letter-spacing: 0px;font-size: 16px;font-family: \u5b8b\u4f53;\"><br  \/><\/span><\/p>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"padding: 3px;max-width: 100%;box-sizing: border-box;display: inline-block;background-color: rgb(249, 110, 87);word-wrap: break-word !important;\">\n<section style=\"padding: 2px 8px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: dotted;border-color: rgb(255, 255, 255);color: rgb(255, 255, 255);line-height: 1.4em;font-size: 14px;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u6848\u4f8b3\uff1a\u7279\u7acb\u5e15\u80bd<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;font-size: 14px;color: rgb(5, 5, 5);line-height: 1.5;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;\">\u7279\u7acb\u5e15\u80bd\u662f PTH \u7c7b\u4f3c\u7269\uff0c<span style=\"color: rgb(255, 76, 0);\">\u4e8e2002\u5e74\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u7edd\u7ecf\u540e\u5987\u5973\u7684\u9aa8\u8d28\u758f\u677e<\/span>\u3002\u8be5\u6279\u51c6\u5c40\u9650\u4e8e\u6cbb\u7597\u5468\u671f\u572818-24\u4e2a\u6708\u4ee5\u53ca\u5177\u6709\u9ad8\u9aa8\u6298\u98ce\u9669\u7684\u4e25\u91cd\u9aa8\u8d28\u758f\u677e\u60a3\u8005\uff0c\u4f7f\u7528\u65f6\u95f4\u9650\u5236\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u4e0eFisher 344\u5927\u9f20\u81f4\u764c\u5b9e\u9a8c\u7814\u7a76\u4e2d\u7684\u9aa8\u8089\u7624\u53ca\u5176\u4ed6\u9aa8\u80bf\u7624\u7684\u53d1\u751f\u6709\u5173\uff0c\u7531\u4e8e\u8fd9\u4e9b\u5927\u9f20\u7684\u6bd2\u6027\u6570\u636e\uff0c\u7279\u7acb\u5e15\u80bd\u7684\u4e34\u5e8a\u2162\u8bd5\u9a8c\u88ab\u63a8\u8fdf\u3002<span style=\"color: rgb(255, 76, 0);\">\u56e0\u4e3a\u7279\u7acb\u5e15\u80bd\u88ab\u7ec8\u6b62\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u4e86\u5176\u663e\u8457\u7684\u7597\u6548<\/span>\uff0cFDA\u53caEMA\u548c\u5176\u4ed6\u5730\u533a\u76f8\u5173\u673a\u6784\u76f8\u7ee7\u6279\u51c6\u4e86\u7279\u7acb\u5e15\u80bd\u7684\u5e94\u7528\uff0c\u540c\u65f6\u89c4\u5b9a\u4f7f\u7528\u65f6\u95f4\u4e0d\u80fd\u8d85\u8fc72\u5e74\u3002\u867d\u7136\u4e34\u5e8a\u5e94\u7528\u6709\u8bf8\u591a\u9650\u5236\uff0c\u4f46\u7531\u4e8e\u5176\u663e\u8457\u7684\u7597\u6548\uff0c\u4e0a\u5e02\u540e\u9500\u552e\u989d\u7a33\u6b65\u589e\u957f\uff0c<span style=\"color: rgb(255, 76, 0);\">2017\u5e74\u7ea6\u4e3a18\u4ebf\u7f8e\u91d1\u3002<\/span><\/p>\n<p style=\"margin-left: 0;text-indent: 0;padding: 0;line-height: 150%;\"><span style=\"font-family:Calibri;color:rgb(12,12,12);font-size:14px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537925716.jpg\" alt=\"\u90a3\u4e9b\u5177\u6709\u201c\u81f4\u764c\u201d\u4f5c\u7528\u7684\u91cd\u78c5\u836f\u7269\" title=\"\u90a3\u4e9b\u5177\u6709\u201c\u81f4\u764c\u201d\u4f5c\u7528\u7684\u91cd\u78c5\u836f\u7269\"  \/><\/p>\n<p style=\"text-align: center;\">\u56fe2. \u7279\u7acb\u5e15\u80bd\u9ed1\u6846\u8b66\u544a<br  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: rgb(255, 76, 0);\">\u5728\u7b2c\u4e00\u4e2a24\u4e2a\u6708\u7684\u81f4\u764c\u6027\u5b9e\u9a8c\u4e2d\uff0c<\/span>8\u5468\u9f84\u7684Fisher 344\u5927\u9f20\u76ae\u4e0b\u6ce8\u5c04\u7279\u7acb\u5e15\u80bd5\u3001&nbsp;30\u621675 mcg\/kg\/day, \u5176\u7cfb\u7edf\u66b4\u9732\u91cf\u662f\u4e34\u5e8a\u6cbb\u7597\u5242\u91cf20mcg\/day\u4e0b\u4eba\u4f53\u7cfb\u7edf\u66b4\u9732\u91cf\u76843\u300120\u548c60\u500d\u3002\u5728\u7ed9\u836f\u7ec4\uff0c\u96cc\u96c4\u5927\u9f20\u9aa8\u8089\u7624\u7684\u53d1\u751f\u7387\u663e\u8457\u589e\u52a0\u3002\u6240\u6709\u5242\u91cf\u7ec4\u5747\u89c2\u5bdf\u5230\u9aa8\u8089\u7624\uff0c\u800c\u9ad8\u5242\u91cf\u9aa8\u8089\u7624\u53d1\u751f\u7387\u9ad8\u8fbe40-50%\u3002\u540c\u65f6\uff0c\u6210\u9aa8\u7ec6\u80de\u7624\u548c\u9aa8\u7624\u7684\u53d1\u751f\u7387\u4e5f\u660e\u663e\u589e\u52a0\u4e86\uff0c\u4e14\u5448\u5242\u91cf\u76f8\u5173\u6027\u3002\u5728\u5bf9\u7167\u7ec4\uff0c\u672a\u89c2\u5bdf\u5230\u9aa8\u8089\u7624\u3001\u6210\u9aa8\u7ec6\u80de\u7624\u548c\u9aa8\u7624\u3002<span style=\"color: rgb(255, 76, 0);\">\u5927\u9f20\u9aa8\u80bf\u7624\u7684\u53d1\u751f\u4e0e\u9aa8\u91cf\u5927\u91cf\u589e\u52a0\u548c\u5c40\u7076\u6027\u6210\u9aa8\u7ec6\u80de\u589e\u751f\u6709\u5173\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: rgb(255, 76, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\">\u7b2c\u4e8c\u4e2a\u81f4\u764c\u5b9e\u9a8c\u662f\u4e3a\u4e86\u786e\u5b9a\u7ed9\u836f\u5468\u671f\u548c\u52a8\u7269\u5e74\u7eaa\u5bf9\u9aa8\u80bf\u7624\u53d1\u5c55\u5f97\u5f71\u54cd\u3002\u4e0d\u6210\u719f\u76842\u4e2a\u6708\u9f84\u548c\u6210\u719f\u76846\u4e2a\u6708\u9f84\u7684\u96cc\u6027\u5927\u9f20\u5206\u522b\u76ae\u4e0b\u6ce8\u5c045\u548c&nbsp;30 mcg\/kg\/day&nbsp;\uff0c\u7ed9\u836f\u5468\u671f\u957f\u77ed\u4e0d\u540c\u3002<span style=\"color: rgb(255, 76, 0);\">\u7ed3\u679c\u663e\u793a\u9aa8\u8089\u7624\u3001\u6210\u9aa8\u7ec6\u80de\u7624\u548c\u9aa8\u7624\u7684\u53d1\u751f\u4f9d\u8d56\u4e8e\u7ed9\u836f\u5242\u91cf\u548c\u6301\u7eed\u5468\u671f\u3002<\/span>2\u4e2a\u6708\u9f84\u7684\u5927\u9f20\u4ee5&nbsp;30 mcg\/kg\/day&nbsp;\u7ed9\u836f24\u4e2a\u6708\u6216\u80055mcg\/kg\/day&nbsp;\u548c30 mcg\/kg\/day \u7ed9\u836f6 \u4e2a\u6708\u540e\u5747\u89c2\u5bdf\u5230\u9aa8\u80bf\u7624\uff1b6\u4e2a\u6708\u9f84\u7684\u5927\u9f20\u4ee530 mcg\/kg\/day \u7ed9\u836f6 \u4e2a\u6708\u621620\u4e2a\u6708\u540e\u4e5f\u53d1\u73b0\u80bf\u7624\uff0c\u4f466\u4e2a\u6708\u9f84\u7684\u5927\u9f20\u4ee55&nbsp;mcg\/kg\/day \u7ed9\u836f6 \u4e2a\u6708\u621620\u4e2a\u6708\u540e\u672a\u53d1\u73b0\u80bf\u7624\u3002<span style=\"color: rgb(255, 76, 0);\">\u5b9e\u9a8c\u7ed3\u679c\u4e0d\u80fd\u8bf4\u660e\u80bf\u7624\u5f62\u6210\u4e0e\u5927\u9f20\u662f\u5426\u6210\u719f\u6709\u533a\u522b\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u4e00\u4e2a\u957f\u671f\u5b9e\u9a8c\u4e2d\uff0c\u9aa8\u9abc\u6210\u719f\u7684\u5207\u9664\u5375\u5de2\u7684\u96cc\u6027\u7334\u5b50\uff08n=30\uff09\u8fde\u7eed\u76ae\u4e0b\u6ce8\u5c04\u7279\u7acb\u5e15\u80bd5mcg\/kg\/day\u6216\u7ed9\u836f\u6eb6\u5a92\u3002\u8fde\u7eed\u7ed9\u836f18\u4e2a\u6708\u540e\uff0c\u518d\u7ee7\u7eed\u89c2\u5bdf\u4e863\u5e74\u3002\u7334\u5b50\u7684\u66b4\u9732\u91cf\u662f\u4e34\u5e8a\u6cbb\u7597\u5242\u91cf\u4e0b\u4eba\u4f53\u66b4\u9732\u91cf\u76846\u500d\u3002\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u4efb\u4f55\u4e00\u53ea\u7334\u5b50\u5728\u5f71\u50cf\u5b66\u6216\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\u4e2d\u5747\u672a\u68c0\u6d4b\u5230\u80bf\u7624\u3002<span style=\"color: rgb(255, 76, 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0);\">FDA\u8981\u6c42\u589e\u52a0\u9ed1\u6846\u8b66\u544a\uff0c\u5e76\u4e14\u7981\u6b62\u7528\u4e8e\u60a3\u9aa8\u8089\u7624\u98ce\u9669\u9ad8\u4e8e\u57fa\u7ebf\u6c34\u5e73\u7684\u60a3\u8005\u3002<\/span>\u6b64\u5916\uff0c\u4e3a\u4e86\u8bc4\u4ef7\u7279\u7acb\u5e15\u80bd\u548crhPTH(1-34)\u4e0e\u9aa8\u8089\u7624\u7684\u6f5c\u5728\u76f8\u5173\u6027\uff0cFDA\u8fd8\u4e3b\u5bfc\u4e86\u4e00\u9879\u4e3a\u671f15\u5e74\uff082003-2018\uff09\u7684\u4e0a\u5e02\u540e\u7814\u7a76\u3002Andrews\u7b49\u62a5\u9053\u4e86\u7279\u7acb\u5e15\u80bd\u4e0a\u5e02\u540e7\u5e74\u7684\u76d1\u6d4b\u6570\u636e\uff0c<span style=\"color: rgb(255, 76, 0);\">\u7ed3\u679c\u663e\u793a\u65e0\u4e00\u4f8b\u9aa8\u8089\u7624\u60a3\u8005\u5728\u8bca\u65ad\u524d\u4f7f\u7528\u8fc7\u7279\u7acb\u5e15\u80bd\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"color: rgb(255, 76, 0);\"><strong>\u81f4\u764c\u6027\u6570\u636e\u89e3\u8bfb<\/strong><\/span><\/p>\n<p style=\"margin-left: 0;text-indent: 0;padding: 0;line-height: 150%;\"><strong><span style=\"line-height: 150%;color: rgb(12, 12, 12);font-size: 16px;font-family: \u5b8b\u4f53;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-align: justify;\">3\u4e2a\u5b9e\u4f8b\u8bf4\u660e\u81f4\u764c\u6027\u5b9e\u9a8c\u7ed3\u679c\u7684\u5206\u6790\u662f\u5341\u5206\u590d\u6742\u7684\uff0c<span style=\"color: rgb(255, 76, 0);\">\u9700\u8981\u786e\u8ba4\u4e24\u4e2a\u5927\u95ee\u9898\uff1a<\/span>\u4e00\u3001 \u53d7\u8bd5\u836f\u7269\u662f\u5426\u6709\u81f4\u764c\u4f5c\u7528\uff1b\u4e8c\u3001\u81f4\u764c\u7ed3\u679c\u7684\u79cd\u5c5e\u5916\u63a8\uff0c\u8bc4\u4ef7\u556e\u9f7f\u7c7b\u52a8\u7269\u81f4\u764c\u4e0e\u4eba\u7c7b\u81f4\u764c\u7684\u76f8\u5173\u6027\u3002<\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: rgb(255, 76, 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0);\">150\u591a\u79cd\u5df2\u4e0a\u5e02\u836f\u7269\u5728\u81f4\u764c\u6027\u5b9e\u9a8c\u4e2d\u663e\u793a\u589e\u52a0\u556e\u9f7f\u7c7b\u52a8\u7269\u81f4\u764c\u98ce\u9669\uff0c<\/span>\u4f46\u5728\u4e34\u5e8a\u4e2d\uff0c\u53ea\u67098\u79cd\u836f\u7269\u88ab\u8ba4\u4e3a\u5bf9\u4eba\u7c7b\u5177\u6709\u81f4\u764c\u6027\u3002\u81f4\u764c\u6027\u5b9e\u9a8c\u663e\u793a\u5bf9\u52a8\u7269\u5177\u6709\u81f4\u764c\u4f5c\u7528\u7684\u836f\u7269\u5728\u4e34\u5e8a\u4e0a\u4e0d\u4e00\u5b9a\u5bf9\u4eba\u7c7b\u5177\u6709\u81f4\u764c\u4f5c\u7528\uff0c\u9700\u79d1\u5b66\u614e\u91cd\u5730\u5206\u6790\u8bc4\u4ef7\u52a8\u7269\u81f4\u764c\u4e0e\u4eba\u7c7b\u81f4\u764c\u7684\u76f8\u5173\u6027\u3002<\/p>\n<p style=\"text-align: center;\">&nbsp;<\/p>\n<p style=\"text-align: center;\">\u88683. \u81f4\u764c\u7ed3\u679c\u7684\u79cd\u5c5e\u5916\u63a8<\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537925716.jpg\" alt=\"\u90a3\u4e9b\u5177\u6709\u201c\u81f4\u764c\u201d\u4f5c\u7528\u7684\u91cd\u78c5\u836f\u7269\" title=\"\u90a3\u4e9b\u5177\u6709\u201c\u81f4\u764c\u201d\u4f5c\u7528\u7684\u91cd\u78c5\u836f\u7269\"  \/><\/p>\n<p style=\"margin-left: 0;text-indent: 0;padding: 0;line-height: 150%;\"><span style=\"font-family:\u5b8b\u4f53;font-size:14px;\">&nbsp;<\/span><br  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14px;\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14px;\">1.&nbsp;\u5229\u57f9\u916e\u3001\u5229\u62c9\u9c81\u80bd\u3001\u7279\u7acb\u5e15\u80bd\u836f\u54c1\u8bf4\u660e\u4e66<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14px;\">2.&nbsp;Elizabeth B Andrews,1 Alicia W Gilsenan,1 Kirk Midkiff. The US Postmarketing Surveillance Study of Adult Osteosarcoma and Teriparatide: Study Design and Findings From the First 7 Years. Journal of Bone and Mineral Research, Vol. 27, No. 12, December 2012, pp 2429\u20132437&nbsp;<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6392\u7248\uff1a\u6587\u7af9<\/span><br style=\"max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<hr style=\"max-width: 677px;box-sizing: border-box;word-wrap: break-word;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;\"  \/>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;word-wrap: break-word !important;\">\n<section style=\"margin-right: 3px;margin-left: 3px;padding: 20px;max-width: 677px;box-sizing: border-box;word-wrap: break-word;background-color: rgb(254, 254, 254);border-color: rgb(210, 150, 20);box-shadow: rgb(210, 150, 20) 0px 0px 4px;\">\n<p style=\"max-width: 631px;box-sizing: border-box;word-wrap: break-word;min-height: 18px;color: rgb(210, 150, 20);font-size: 18px;font-weight: 700;min-width: 1px;\">\u57f9\u8bad\u548c\u4f1a\u8bae\uff1a<\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 593.6px;box-sizing: border-box;word-wrap: break-word;min-height: 17px;color: rgb(6, 6, 6);letter-spacing: 0.54px;\"><span style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;font-size: 15px;\">\u540c\u5199\u610f\u57f9\u8bad<\/span><\/p>\n<\/li>\n<\/ul>\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 631px;box-sizing: border-box;word-wrap: break-word;border-color: rgb(210, 150, 20);\">\n<p style=\"max-width: 631px;box-sizing: border-box;word-wrap: break-word;min-height: 17px;letter-spacing: 0.54px;\"><span style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;color: rgb(172, 57, 255);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);\">&nbsp; &nbsp;<\/span><\/p>\n<h2 class=\"rich_media_title\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650624081&amp;idx=1&amp;sn=c5f77cee20dc1335acc21f30ad489921&amp;scene=21#wechat_redirect\" target=\"_blank\">\u5199\u610f\u5de8\u732e\u4e2830\u4f4d\u4e13\u5bb6\u8bba\u9053\u4e0a\u6d77\u6ee9\uff1a\u65b0\u836f\u4e2d\u7f8e\u53cc\u62a5\u4e4b\u4e34\u5e8a\u7814\u7a76\u5cf0\u4f1a<\/a><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<hr style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;word-wrap: break-word !important;\"  \/>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: center;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;font-size: 15px;\">\u836f\u4e8b\u7eb5\u6a2a\u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u73b0\u6709\u6210\u545834\u540d\uff0c\u5206\u522b\u4e3aVoyager88\uff0c\u96f7\u8bfa\u5c9b\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0cyhqqqqq\uff0c\u5360\u5c0f\u5175\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0cflydp511\uff0c\u5de7\u5de7\uff0c\u9621\u4e0a\u964c\u964c\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0cKailyn\uff0cSeven\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cVicky\uff0cSophia \uff0c\u4f9d\u7136\u7279\u96f7\u897f\uff0c\u5076\u9635\u96e8\uff0cAimee\uff0c\u4ed6\u5c71\u4e4b\u77f3\uff0c\u96f6\u4e0b274\u2103\uff0cBreathless\uff0cLuffy\uff0c\u80e1\u4e0d\u559c\uff0c&nbsp;Helen\uff0c\u7b49\u7b49\uff0cSUNRISE\uff0cZMJ\uff0c\u6da6\u513f\uff0cJessie\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1442015666\uff0c\u836f\u4e8b\u7eb5\u6a2a\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><span yahei=\"yahei\" sans=\"sans\" helvetica=\"helvetica\" px=\"px\" gb=\"gb\" neue=\"neue\" none=\"none\" left=\"left\" normal=\"normal\" ui=\"ui\" sc=\"sc\" style=\"max-width: 100%;float: none;background-color: transparent;box-sizing: border-box !important;word-wrap: break-word !important;display: inline !important;\">&nbsp;&nbsp;<\/span><\/p>\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6458\u8981&nbsp; 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