{"id":47034,"date":"2018-09-21T01:00:00","date_gmt":"2018-09-26T01:35:22","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e5%9c%a8%e7%a0%94%e8%8d%af%e7%89%a9%e4%b8%ad%e9%9a%be%e6%ba%b6%e8%8d%af%e9%ab%98%e8%be%be90%ef%bc%8c%e4%bd%a0%e8%af%a5%e5%a6%82%e4%bd%95%e5%8e%bb%e6%90%9e%e5%ae%9a%ef%bc%9f\/"},"modified":"2018-09-26T09:35:25","modified_gmt":"2018-09-26T01:35:25","slug":"%e5%9c%a8%e7%a0%94%e8%8d%af%e7%89%a9%e4%b8%ad%e9%9a%be%e6%ba%b6%e8%8d%af%e9%ab%98%e8%be%be90%ef%bc%8c%e4%bd%a0%e8%af%a5%e5%a6%82%e4%bd%95%e5%8e%bb%e6%90%9e%e5%ae%9a%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/47034\/","title":{"rendered":"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f"},"content":{"rendered":"
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\u7b2c\u4e00\u7ae0\u56fa\u4f53\u5206\u6563\u4f53<\/span><\/p>\n

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1.1<\/span><\/strong>\u56fa\u4f53\u5206\u6563\u4f53\u7684\u53d1\u5c55\u5386\u53f2<\/span><\/strong><\/p>\n\n\n\n
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\u56fa\u4f53\u5206\u6563\u4f53\u662f\u6307\u836f\u7269\u9ad8\u5ea6\u5206\u6563\u5728\u9002\u5b9c\u7684\u8f7d\u4f53\u6750\u6599\u4e2d\u5f62\u6210\u7684\u4e00\u79cd\u56fa\u6001\u7269\u8d28\uff0c\u7c7b\u4f3c\u4e8e\u6db2\u4f53\u7cfb\u7edf\u7684\u6eb6\u6db2\u6216\u6df7\u60ac\u6db2\u3002\u56fa\u4f53\u5206\u6563\u4f53\u7684\u6982\u5ff5\u6700\u65e9\u7531<\/span>Sekiguchi<\/span>\u548c<\/span>Obi<\/span>\u63d0\u51fa\uff0c\u65f6\u81f3\u4eca\u65e5\u5df2\u8fd1<\/span>60<\/span>\u5e74\uff0c\u5728\u6b64\u671f\u95f4\uff0c\u56fa\u4f53\u5206\u6563\u4f53\u5df2\u7ecf\u53d1\u5c55\u4e86\u4e09\u4ee3\uff0c\u7b2c\u4e00\u4ee3\u662f\u4ee5\u5c3f\u7d20\u7b49\u7ed3\u6676\u6027\u7269\u8d28\u4e3a\u6750\u6599\uff0c\u7b2c\u4e8c\u4ee3\u5219\u662f<\/span>PEG<\/span>\u3001<\/span>PVP<\/span>\u7b49\u4e3a\u6750\u6599\uff0c\u7b2c\u4e09\u4ee3\u5219\u4ee5\u8868\u9762\u6d3b\u6027\u5242\u4e3a\u6750\u6599\uff0c\u8fd1\u5e74\u4e0a\u5e02\u7684\u56fa\u4f53\u5206\u6563\u4f53\u5219\u4ee5<\/span>HPMC<\/span>\u6216<\/span>HPMCAS<\/span>\u4e3a\u8f7d\u4f53\u7684\u5c45\u591a\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

1.2<\/span><\/strong>\u56fa\u4f53\u5206\u6563\u4f53\u7684\u5236\u5907\u65b9\u6cd5<\/span><\/strong><\/p>\n\n\n\n
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\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"<\/p>\n

\u7194\u878d\u6cd5<\/span><\/strong><\/p>\n\n\n\n
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\u7194\u878d\u6cd5\u987e\u540d\u601d\u4e49\u662f\u5c06\u836f\u7269\u548c\u8f7d\u4f53\u6309\u6bd4\u4f8b\u5236\u6210\u4f4e\u5171\u7194\u4f53\u6216\u56fa\u4f53\u6eb6\u6db2\uff0c\u7136\u540e\u8fc5\u901f\u51b7\u5374\u4f7f\u5176\u5f62\u6210\u56fa\u4f53\u5206\u6563\u4f53\u3002\u8fd9\u79cd\u5de5\u827a\u5f80\u5f80\u5bf9\u539f\u6599\u548c\u8f7d\u4f53\u7684\u8981\u6c42\u6bd4\u8f83\u9ad8\uff0c\u8981\u6c42<\/span>API<\/span>\u548c\u8f7d\u4f53\u540c\u65f6\u878d\u5316\u6216<\/span>API<\/span>\u6eb6\u89e3\u5728\u878d\u5316\u7684\u8f7d\u4f53\u4e2d\u800c\u4e8c\u8005\u4e0d\u80fd\u964d\u89e3\u3002\u5f97\u76ca\u4e8e\u8fd1\u5e74\u6765\u6750\u6599\u79d1\u5b66\u548c\u673a\u68b0\u8bbe\u5907\u7684\u9ad8\u901f\u53d1\u5c55\uff0c\u70ed\u7194\u6324\u51fa\u548c\u70ed\u7194\u5438\u9644\u5de5\u827a\u5df2\u7ecf\u6210\u719f\uff0c\u6210\u529f\u7684\u56fa\u4f53\u5206\u6563\u4f53\u4e2d\u57fa\u672c\u68c0\u6d4b\u4e0d\u5230\u7ed3\u6676\u836f\u7269\u7684\u5b58\u5728\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u6eb6\u5242\u6cd5<\/span><\/strong><\/p>\n\n\n\n
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\u6eb6\u5242\u6cd5\u662f\u6700\u4f20\u7edf\u7684\u56fa\u4f53\u5206\u6563\u4f53\u5236\u5907\u65b9\u6cd5\uff0c\u5c06\u8f7d\u4f53\u548c<\/span>API<\/span>\u5171\u6eb6\u4e8e\u826f\u6027\u6eb6\u5242\u4e2d\uff0c\u7136\u540e\u84b8\u5e72\u6eb6\u5242\u5f97\u56fa\u4f53\u5206\u6563\u4f53\u3002\u8fd9\u79cd\u65b9\u6cd5\u64cd\u4f5c\u7b80\u5355\uff0c\u8bbe\u5907\u5ec9\u4ef7\uff0c\u6bd4\u8f83\u9002\u4e8e\u5b9e\u9a8c\u5ba4\u5236\u5907\uff0c\u7f3a\u70b9\u5728\u4e8e\u5f62\u6210\u56fa\u4f53\u5206\u6563\u4f53\u8fc7\u7a0b\u4e0d\u591f\u5267\u70c8\uff0c\u56fa\u4f53\u5206\u6563\u4f53\u4e2d\u5fae\u6676\u6001\u3001\u80f6\u4f53\u6001\u6bd4\u4f8b\u8f83\u9ad8\uff0c\u800c\u4e14\u5de5\u827a\u65e0\u6cd5\u7ebf\u6027\u653e\u5927\uff0c\u5de5\u827a\u7a33\u5b9a\u6027\u96be\u4ee5\u4fdd\u969c\u3002\u55b7\u96fe\u5e72\u71e5\u6280\u672f\u7684\u5e94\u7528\u5f88\u5927\u7a0b\u5ea6\u4e0a\u89e3\u51b3\u4e86\u8fd9\u4e00\u95ee\u9898\uff0c\u4f46\u6210\u672c\u8f83\u9ad8\uff0c\u9700\u4f7f\u7528\u7279\u6b8a\u7684\u55b7\u96fe\u5e72\u71e5\u8bbe\u5907\uff0c\u800c\u4e14\u5de5\u827a\u4e2d\u6325\u53d1\u6eb6\u5242\u7684\u5904\u7406\u4e5f\u662f\u4e00\u5927\u95ee\u9898\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u673a\u68b0\u5206\u6563\u6cd5<\/span><\/strong><\/p>\n\n\n\n
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\u673a\u68b0\u5206\u6563\u6cd5\u5236\u5907\u7684\u56fa\u4f53\u5206\u6563\u4f53\u4e0e\u4e0a\u8ff0\u65b9\u6cd5\u5236\u5907\u7684\u56fa\u4f53\u5206\u6563\u4f53\u6709\u672c\u8d28\u7684\u533a\u522b\u3002\u56e0\u4e3a\u673a\u68b0\u5206\u6563\u6cd5\u662f\u901a\u8fc7\u5f3a\u5927\u7684\u673a\u68b0\u80fd\u5c06\u836f\u7269\u9897\u7c92\u9ad8\u5ea6\u5206\u6563\u4e8e\u8f7d\u4f53\u4e2d\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5f97\u5230\u7684\u4ea7\u54c1<\/span>API<\/span>\u4e3b\u8981\u5904\u4e8e\u5fae\u6676\u6001\uff0c\u589e\u6eb6\u80fd\u529b\u6709\u9650\u3002\u5c06<\/span>API<\/span>\u548c\u8f85\u6599\uff08\u5982\u4e73\u7cd6\u3001\u5fae\u6676\u7ea4\u7ef4\u7d20\uff09\u5171\u7c89\u788e\u662f\u5236\u5242\u5b66\u4e2d\u6700\u5e38\u7528\u7684\u65b9\u6cd5\uff0c\u64cd\u4f5c\u7b80\u5355\uff0c\u6613\u4e8e\u63a7\u5236\u3002\u76ee\u524d\u7c89\u788e\u673a\u68b0\u5df2\u7ecf\u76f8\u5f53\u53d1\u8fbe\uff0c\u4f7f\u7528\u673a\u68b0\u7c89\u788e\u673a\u53ef\u5c06\u7c92\u5ea6\u7c89\u788e\u81f3<\/span>10<\/span>\u5fae\u7c73\u4ee5\u4e0b\uff0c\u6c14\u6d41\u7c89\u788e\u673a\u53ef\u7c89\u788e\u81f3<\/span>5<\/span>\u5fae\u7c73\u4ee5\u4e0b\uff0c\u4f7f\u7528\u5747\u8d28\u673a\uff0c\u53ef\u5c06\u7c92\u5ea6\u63a7\u5236\u5230<\/span>1<\/span>\u5fae\u7c73\u4ee5\u4e0b\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

1.3 <\/span><\/strong>\u56fa\u4f53\u5206\u6563\u4f53\u7684\u5e94\u7528<\/span><\/strong><\/p>\n\n\n\n
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\u56fa\u4f53\u5206\u6563\u4f53\u5728\u80a0\u9053\u4e2d\u7684\u6eb6\u51fa\u548c\u5438\u6536\u8fc7\u7a0b\u793a\u610f\u56fe<\/span><\/p>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"<\/p>\n\n\n\n
\n

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FDA\u6279\u51c6\u7684\u56fa\u4f53\u5206\u6563\u4f53\u4ea7\u54c1\uff08\u9ec4\u8272\u80cc\u666f\u8868\u793a\u9000\u5e02\uff09<\/span><\/p>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"
<\/span><\/strong>\u7b2c\u4e8c\u7ae0\u3001<\/span>Nanocrystal<\/span><\/p>\n

2.1NanocrystalTM<\/span><\/sup><\/strong><\/span>\u6280\u672f\u7684\u7531\u6765<\/span><\/p>\n\n\n\n
\n

Nanocrystal<\/span>\u987e\u540d\u601d\u4e49\u662f\u7eb3\u7c73\u7ea7\u522b\u7684\u836f\u7269\u6676\u4f53\uff0c\u5f53\u836f\u7269\u7c92\u5f84\u88ab\u7c89\u788e\u81f3\u7eb3\u7c73\u7ea7\u522b\uff0c\u6eb6\u89e3\u5ea6\u4f1a\u5927\u5e45\u589e\u52a0\u3002<\/span>NanocrystalTM<\/sup><\/span>\u5df2\u662f\u4e00\u9879\u5e7f\u6cdb\u5e94\u7528\u7684\u65b0\u6280\u672f\uff0c<\/span>NanocrystalTM<\/sup><\/span>\u6280\u672f\u6700\u65e9\u7531\u7231\u5c14\u5170<\/span>Elan<\/span>\u516c\u53f8\u5f00\u53d1\uff0c<\/span>2011<\/span>\u5e74<\/span>Alkermes<\/span>\u901a\u8fc7<\/span>9.5<\/span>\u4ebf\u7f8e\u5143\u7684\u90e8\u95e8\u6536\u8d2d\uff0c\u5c06\u8be5\u6280\u672f\u5e73\u53f0\u6536\u5165\u56ca\u4e2d\u3002\u622a\u6b62\u76ee\u524d\uff0c\u5df2\u6709\u5341\u4f59\u4e2a\u4f7f\u7528<\/span>NanocrystalTM<\/sup><\/span>\u6280\u672f\u7684\u836f\u7269\u83b7\u5f97<\/span>FDA<\/span>\u6279\u51c6\u4e0a\u5e02\uff0c\u5356\u5230<\/span>100<\/span>\u591a\u4e2a\u56fd\u5bb6\u6216\u5730\u533a\uff0c\u5e74\u9500\u552e\u603b\u989d\u8d85\u8fc7<\/span>30<\/span>\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"<\/p>\n\n\n\n
\n

Nanocrystal<\/span>TM<\/sup>\u6280\u672f\u662f\u901a\u8fc7\u9ad8\u5f3a\u5ea6\u7684\u673a\u68b0\u80fd\u5c06\u836f\u7269\u7c89\u788e\u5230<\/span>20<\/span>\u5fae\u7c73\u4ee5\u4e0b\uff0c\u7136\u540e\u5206\u6563\u5728\u7279\u5b9a\u57fa\u8d28\u4e2d\u4f7f\u5176\u957f\u671f\u7a33\u5b9a\u5b58\u5728\u7684\u4e00\u95e8\u6280\u672f\u3002<\/span>Nanocrystal <\/span>\u4e0d\u540c\u4e8e\u7eb3\u7c73\u7c92\uff0c\u5176\u836f\u7269\u5e76\u975e\u5305\u8f7d\u5728\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\uff0c<\/span>Nanocrystal<\/span>\u4e5f\u4e0d\u540c\u4e8e\u56fa\u4f53\u5206\u6563\u4f53\uff0c\u5176\u5185\u90e8\u6709\u836f\u7269\u6676\u4f53\u5b58\u5728\u3002<\/span>Nanocrystal<\/span>\u7684\u673a\u7406\u5c31\u662f\u901a\u8fc7\u964d\u4f4e\u5206\u5b50\u7c92\u5f84\u800c\u5927\u5e45\u589e\u52a0\u6bd4\u8868\u9762\u79ef\u4ee5\u8fbe\u5230\u63d0\u9ad8\u6eb6\u51fa\u901f\u7387\u7684\u6548\u679c\uff0c\u4e0d\u4f46\u5982\u6b64\uff0c\u5f53\u836f\u7269\u88ab\u7c89\u788e\u5230\u7eb3\u7c73\u7ea7\u522b\uff0c\u5176\u6676\u4f53\u7ed3\u6784\u6216\u90e8\u5206\u6676\u4f53\u7ed3\u6784\u4f1a\u906d\u5230\u7834\u574f\uff0c\u6eb6\u89e3\u5ea6\u589e\u52a0\uff0c\u8fd9\u4e5f\u662f<\/span>Nanocrystal<\/span>\u6280\u672f\u80fd\u63d0\u9ad8\u751f\u7269\u5229\u7528\u5ea6\u7684\u539f\u56e0\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

2.2NanocrystalTM<\/sup><\/span><\/strong>\u6280\u672f\u7684\u5e94\u7528<\/span><\/strong><\/p>\n

\u975e\u8bfa\u8d1d\u7279<\/span><\/strong><\/p>\n\n\n\n
\n

\u96c5\u57f9\u7684\u975e\u8bfa\u8d1d\u7279\u6700\u65e9\u83b7\u6279\u4e8e<\/span>1993<\/span>\u5e74\uff0c\u5546\u54c1\u540d\u4e3a<\/span>Lipidil<\/span>\uff0c\u4f46\u56e0\u4e3a\u751f\u7269\u5229\u7528\u5ea6\u4e0d\u7406\u60f3\uff0c\u591a\u6b21\u6539\u826f\u5904\u65b9\uff0c\u76f4\u81f3\u4f7f\u7528<\/span>Nanocrystal<\/span>\u6280\u672f\u7684<\/span>Tricor<\/span>\u4e0a\u5e02\u3002<\/span>Lipidil<\/span>\u7684\u6700\u5927\u89c4\u683c\u4e3a<\/span>200mg<\/span>\uff0c\u800c\u4e14\u9700\u8981\u5728\u9910\u65f6\u670d\u7528\uff0c<\/span>Tricar<\/span>\u65e0\u9700\u540c\u996e\u98df\u670d\u7528\uff0c\u800c\u4e14\u6700\u5927\u5242\u91cf\u4ece<\/span>200mg<\/span>\u5c06\u81f3<\/span>145mg<\/span>\u3002\u6839\u636e\u539f\u7814\u4e13\u5229\u62a5\u9053\uff0c\u9996\u5148\u662f\u5c06<\/span>API<\/span>\u7c89\u788e\u81f3<\/span>5<\/span>\u5fae\u7c73\uff0c\u7136\u540e\u5c06<\/span>API<\/span>\u6df7\u60ac\u5728\u542b\u8868\u9762\u6d3b\u6027\u5242\u7684\u6db2\u4f53\u4e2d\uff0c\u518d\u5728\u5267\u70c8\u6405\u62cc\u4e0b\u4e0e\u4eb2\u6c34\u6027\u57fa\u8d28\uff08<\/span>PVP<\/span>\uff09\u5f62\u6210\u6df7\u60ac\u6db2\uff0c\u6700\u540e\u518d\u5c06\u6df7\u60ac\u6db2\u55b7\u96fe\u5230\u4e73\u7cd6\u6216\u5176\u5b83\u8f85\u6599\u4e0a\uff0c\u7136\u540e\u6df7\u5408\u538b\u7247\u800c\u5f97\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u963f\u745e\u5339\u5766<\/span><\/strong><\/p>\n\n\n\n
\n

\u963f\u745e\u5339\u5766\u83b7\u6279\u4e8e<\/span>2003<\/span>\u5e74\uff0c\u5546\u54c1\u540d\u4e3a<\/span>Emend<\/span>\u3002\u963f\u745e\u5339\u5766\u7684\u5236\u5907\u673a\u7406\u4e0e\u975e\u8bfa\u8d1d\u7279\u76f8\u4f3c\uff0c\u4f46\u4e0e\u975e\u8bfa\u8d1d\u7279\u4e0d\u540c\u7684\u662f\u963f\u745e\u5339\u5766\u88ab\u7c89\u788e\u81f3<\/span>100nm<\/span>\u7684\u6c34\u5e73\u3002\u56e0\u4e3a\u7c92\u5ea6\u8f83\u5c0f\uff0c\u6bd4\u8868\u9762\u79ef\u5927\uff0c\u800c\u4e14\u90e8\u5206\u6676\u4f53\u7ed3\u6784\u5df2\u7ecf\u88ab\u7834\u574f\uff0c\u6240\u4ee5\u6eb6\u51fa\u901f\u7387\u548c\u6eb6\u51fa\u5ea6\u90fd\u52a0\u5927\uff0c\u751f\u7269\u5229\u7528\u5ea6\u5927\u5e45\u63d0\u9ad8\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5e15\u5229\u54cc\u916e<\/span><\/strong><\/p>\n\n\n\n
\n

\u5e15\u5229\u54cc\u916e\u7f13\u91ca\u6ce8\u5c04\u6db2\u4e8e<\/span>2009<\/span>\u5e74\u4e0a\u5e02\uff0c\u5546\u54c1\u540d\u4e3a<\/span>INVEGA SUSTENNA<\/span>\uff0c<\/span>2015<\/span>\u5e74\u53c8\u4e0a\u5e02\u4e86\u4e09\u6708\u4e00\u6b21\u7684\u8d85\u957f\u6548\u914d\u65b9\uff0c\u5546\u54c1\u540d\u4e3a<\/span>INVEGA TRINZA<\/span>\u3002\u5e15\u5229\u54cc\u916e\u4e5f\u662f\u4e00\u4e2a\u5178\u578b\u7684<\/span>Nanocrystal<\/span>\u4ea7\u54c1\uff0c\u4e0e\u53e3\u670d<\/span>Nanocrystal<\/span>\u4ea7\u54c1\u4e0d\u4e00\u6837\u7684\u662f<\/span>INVEGA TRINZA<\/span>\u662f\u5229\u7528\u836f\u7269\u7684\u96be\u6eb6\u7279\u70b9\u8fdb\u884c\u7f13\u91ca\u91ca\u653e\uff0c\u4e3a\u4e86\u589e\u52a0\u6d3e\u5229\u54cc\u916e\u7684\u758f\u6c34\u6027\uff0c\u5c06\u5e15\u5229\u54cc\u916e\u5206\u5b50\u4e0a\u94fe\u63a5\u4e86\u8102\u80aa\u94fe\u5236\u6210\u524d\u836f\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

2.3NanocrystalTM<\/sup><\/span><\/strong>\u6280\u672f\u7684\u524d\u666f<\/span><\/strong><\/p>\n\n\n\n
\n

\u622a\u6b62\u76ee\u524d<\/span>FDA<\/span>\u6279\u51c6\u4e86<\/span>11<\/span>\u4e2a<\/span>NanocrystalTM<\/sup><\/span>\u6280\u672f\u4ea7\u54c1\uff0c\u5e15\u5229\u54cc\u916e\u548c\u963f\u7acb\u54cc\u5511\u7f13\u91ca\u6ce8\u5c04\u6db2\u7684\u4e0a\u5e02\uff0c\u4e3a<\/span>NanocrystalTM<\/sup><\/span>\u6280\u672f\u5728\u7f13\u91ca\u6ce8\u5c04\u6db2\u7684\u5e94\u7528\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/span>NanocrystalTM<\/sup><\/span>\u662f\u4f7f\u7528\u6e7f\u78e8\u6280\u672f\uff08<\/span>Wet-milltechnology<\/span>\uff09\u5c06<\/span>API<\/span>\u7c89\u788e\u81f3<\/span>20<\/span>\u5fae\u7c73\u4ee5\u4e0b\uff0c\u751a\u81f3\u6570\u767e\u7eb3\u7c73\u7ea7\u522b\u4e3a\u7279\u5f81\u7684\u6280\u672f\uff0c\u968f\u7740\u56fd\u5185\u7684\u7c89\u788e\u8bbe\u5907\u548c\u7c92\u5ea6\u63a7\u5236\u8bbe\u5907\u65e5\u8d8b\u6210\u719f\uff0c<\/span>Nanocrystal<\/span>\u6280\u672f\u4e5f\u4e0d\u518d\u9065\u4e0d\u53ef\u53ca\u3002\u9664<\/span>Elan<\/span>\u7684<\/span>nanocrystalTM<\/sup><\/span>\u7684\u6280\u672f\u4ee5\u5916\uff0c\u56fd\u5916\u5df2\u7ecf\u5174\u8d77\u5f88\u591a\u7c7b\u4f3c\u7684\u6280\u672f\uff0c<\/span>SkypepharmaI <\/span>\u4f7f\u7528\u7684<\/span>IDD-P<\/span>\u6280\u672f\u5c31\u662f\u4f7f\u7528\u9ad8\u538b\u5747\u8d28\u673a\u5c06\u6df7\u60ac\u7684<\/span>API<\/span>\u6253\u5230\u7eb3\u7c73\u7ea7\u522b\uff0c\u4ee3\u8868\u4ea7\u54c1\u662f<\/span>TRIGLIDE<\/span>\uff08\u975e\u8bfa\u8d1d\u7279\uff09\uff0c\u4e5f\u6709\u7684\u516c\u53f8\u4f7f\u7528\u826f\u6eb6\u5242\u5c06<\/span>API<\/span>\u6eb6\u89e3\uff0c\u518d\u52a0\u5165\u5176\u5b83\u6eb6\u5242\u5c06<\/span>API<\/span>\u6790\u51fa\uff0c\u901a\u8fc7\u63a7\u5236\u6790\u51fa\u6761\u4ef6\u5f97\u5230\u7eb3\u7c73\u6676\u4f53\uff0c\u8fd9\u4e9b\u6280\u672f\u5177\u6709\u8bf8\u591a\u76f8\u4f3c\u4e4b\u5904\uff0c\u76ee\u7684\u4e5f\u90fd\u4e00\u6837\uff0c\u6240\u4ee5\u6211\u4eec\u5236\u5242\u7814\u7a76\u4eba\u5458\u4e5f\u53ef\u4ee5\u5f00\u52a8\u8111\u7b4b\uff0c\u7528\u8fd9\u4e9b\u65b9\u6cd5\u53bb\u89e3\u51b3\u5b9e\u9645\u7684\u95ee\u9898\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

FDA\u6279\u51c6\u7684<\/span>Nanocrystal\u4ea7\u54c1<\/span><\/p>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"
<\/p>\n

\u7b2c\u4e09\u7ae0\u3001\u5305\u5408\u7269<\/span><\/p>\n

3.1<\/span><\/strong>\u5305\u5408\u7269\u7684\u6982\u5ff5<\/span><\/strong><\/p>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"<\/p>\n\n\n\n
\n

\u5305\u5408\u7269\u662f\u6307\u4e00\u79cd\u5206\u5b50\u88ab\u5b8c\u5168\u5305\u542b\u4e8e\u53e6\u4e00\u5206\u5b50\u7684\u7a7a\u7a74\u7ed3\u6784\u4e2d\u5f62\u6210\u7684\u7279\u6b8a\u590d\u5408\u7269\u3002\u76ee\u524d\u5305\u5408\u7269\u7684\u5e94\u7528\u5df2\u7ecf\u5341\u5206\u5e7f\u6cdb\uff0c\u4e0d\u5149\u53ef\u4ee5\u5927\u5e45\u589e\u52a0\u836f\u7269\u7684\u6eb6\u89e3\u5ea6\uff0c\u8fd8\u80fd\u589e\u52a0\u836f\u7269\u7684\u7a33\u5b9a\u6027\uff0c\u6db2\u6001\u836f\u7269\u56fa\u4f53\u5316\u7b49\u3002\u5305\u5408\u7269\u4f7f\u7528\u7684\u5305\u5408\u6750\u6599\u5e38\u5e38\u662f\u03b2<\/span>–<\/span>\u73af\u7cca\u7cbe\uff0c\u56e0\u4e3a<\/span>\u03b2-<\/span>\u73af\u7cca\u7cbe\u5206\u5b50\u7a7a\u7a74\u5927\u5c0f\u6bd4\u8f83\u5408\u9002\uff0c\u6545\u6700\u4e3a\u5e38\u7528\u3002\u7531\u4e8e\u666e\u901a\u7684<\/span>\u03b2-<\/span>\u73af\u7cca\u7cbe\u6eb6\u89e3\u5ea6\u8f83\u4f4e\uff0c\u589e\u6eb6\u80fd\u529b\u6709\u9650\uff0c\u4e3a\u6539\u5584\u5176\u6eb6\u89e3\u5ea6\uff0c\u4eba\u4eec\u5bf9<\/span>\u03b2-<\/span>\u73af\u7cca\u7cbe\u8fdb\u884c\u4e86\u7ed3\u6784\u4fee\u9970\uff0c\u5236\u6210<\/span>\u03b2-<\/span>\u73af\u7cca\u7cbe\u884d\u751f\u7269\uff0c\u76ee\u524d\u5236\u836f\u884c\u4e1a\u6700\u4e3a\u5e38\u7528\u7684\u662f\u7f9f\u4e19\u57fa<\/span>-\u03b2-<\/span>\u73af\u7cca\u7cbe\u548c\u78fa\u4e01\u57fa<\/span>-\u03b2-<\/span>\u73af\u7cca\u7cbe\uff0c\u4e0d\u4f46\u6bd2\u6027\u5c0f\uff0c\u800c\u4e14\u6c34\u4e2d\u6eb6\u89e3\u5ea6\u5927\u3002\u56e0\u4e3a\u73af\u7cca\u7cbe\u548c\u53d7\u5305\u88f9\u5206\u5b50\u7406\u8bba\u4e0a\u53ef\u5f62\u6210<\/span>1:1<\/span>\u7684\u5305\u5408\u7269\uff0c\u6240\u4ee5\u5728\u6c34\u4e2d\u6eb6\u89e3\u5ea6\u8d8a\u5927\u7684\u73af\u7cca\u7cbe\u589e\u6eb6\u80fd\u529b\u8d8a\u5f3a\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"<\/p>\n

3.2<\/span><\/strong>\u5305\u5408\u7269\u7684\u5236\u5907<\/span><\/strong><\/p>\n\n\n\n
\n

\u5236\u5907\u5305\u5408\u7269\u7684\u65b9\u6cd5\u6709\u591a\u79cd\uff0c\u5e38\u89c1\u65b9\u6cd5\u662f\u9971\u548c\u6c34\u6eb6\u6db2\u6cd5\u3001\u7814\u78e8\u6cd5\u3001\u8d85\u58f0\u6cd5\u3001\u55b7\u96fe\u5e72\u71e5\u6cd5\u7b49\u7b49\uff0c\u5176\u4e2d\u6700\u4e3a\u5e38\u7528\u7684\u662f\u9971\u548c\u6c34\u6eb6\u6db2\u6cd5\uff0c\u5178\u578b\u7684\u6848\u4f8b\u5982\u4e09\u5511\u7c7b\u6297\u771f\u83cc\u836f\u6cca\u6c99\u5eb7\u5511\uff0c\u6297\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u836f\u7269\u5361\u975e\u4f50\u7c73\uff0c\u6297\u5fc3\u5f8b\u5931\u5e38\u836f\u80fa\u7898\u916e\u7b49\u3002\u6839\u636e\u6cca\u6c99\u5eb7\u5511\u6ce8\u5c04\u6db2\u4e13\u5229\u62a5\u9053\uff0c\u5176\u5236\u4f5c\u8fc7\u7a0b\u662f\u5c06<\/span>EDTA<\/span>\u548c\u78fa\u4e01\u57fa<\/span>-\u03b2-<\/span>\u73af\u7cca\u7cbe\u6eb6\u4e8e\u9178\u6c34\u4e2d\uff0c\u7136\u540e\u52a0\u5165\u6cca\u6c99\u5eb7\u5511\u6405\u62cc\u81f3\u5305\u5408\u7269\u5f62\u6210\uff0c\u6700\u540e\u52a0\u5165\u78b1\u6c34\u8c03\u5236\u4e2d\u6027\uff0c\u6ee4\u6389\u4e0d\u6eb6\u7269\u5373\u53ef\uff0c\u5c06\u6cca\u6c99\u5eb7\u5511\u5236\u5907\u6210\u5305\u5408\u7269\u540e\uff0c\u6eb6\u89e3\u5ea6\u53ef\u63d0\u9ad8<\/span>1000<\/span>\u500d\u3002\u6b63\u56e0\u4e3a\u5305\u5408\u7269\u7684\u589e\u6eb6\u80fd\u529b\u5f3a\uff0c\u64cd\u4f5c\u7b80\u5355\uff0c\u5305\u5408\u7269\u6280\u672f\u7684\u5e94\u7528\u5df2\u4e0d\u5c40\u9650\u4e8e\u836f\u5242\u5b66\u9886\u57df\uff0c\u7ecf\u9a8c\u4e30\u5bcc\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u5458\u5728\u9047\u5230\u987b\u6ce8\u5c04\u7ed9\u836f\u7684\u6c34\u4e0d\u6eb6\u578b\u836f\u7269\u65f6\uff0c\u9996\u5148\u60f3\u5230\u7684\u89e3\u51b3\u63aa\u65bd\u5c31\u662f\u5236\u5907\u5305\u5408\u7269\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

3.3<\/span><\/strong>\u5305\u5408\u7269\u7684\u5e94\u7528<\/span><\/strong><\/p>\n\n\n\n
\n

\u6b63\u56e0\u4e3a\u5305\u5408\u7269\u5236\u5907\u76f8\u5bf9\u7b80\u5355\uff0c\u5de5\u827a\u63a7\u5236\u70b9\u8f83\u5c11\uff0c\u5305\u5408\u7269\u53d1\u5c55\u81f3\u4eca\u65e5\u5df2\u7ecf\u76f8\u5f53\u6210\u719f\uff0c\u4f46\u662f\u5305\u5408\u7269\u4e5f\u5b58\u5728\u81ea\u5df1\u7684\u5f0a\u7aef\u5c31\u662f\u73af\u7cca\u7cbe\u5177\u6709\u80be\u6bd2\u6027\uff0c\u5c3d\u7ba1\u65b0\u578b\u73af\u7cca\u7cbe\u884d\u751f\u7269\u7684\u6bd2\u6027\u5df2\u5927\u5e45\u964d\u4f4e\uff0c\u4f46\u98ce\u9669\u4ecd\u7136\u5b58\u5728\u3002\u4ece<\/span>FDA<\/span>\u6279\u51c6\u7684\u4ea7\u54c1\u6765\u770b\uff0c\u57fa\u672c\u90fd\u662f\u5176\u5b83\u624b\u6bb5\u65e0\u6cd5\u589e\u6eb6\u6ce8\u5c04\u5242\uff0c\u800c\u7f8e\u56fd\u4ee5\u5916\u7684\u5176\u5b83\u56fd\u5bb6\u5219\u5df2\u6709\u8bb8\u591a\u975e\u6ce8\u5c04\u5242\u54c1\u79cd\u83b7\u6279\uff0c\u5242\u578b\u6709\u7247\u5242\u3001\u80f6\u56ca\u3001\u4e73\u818f\u3001\u820c\u4e0b\u7247\u3001\u5480\u56bc\u7247\u3001\u542b\u7247\u3001\u6813\u5242\u3001\u6ef4\u773c\u6db2\u548c\u9f3b\u55b7\u5242\u7b49\u7b49\u3002\u4e2d\u56fd\u6279\u51c6\u7684\u975e\u6ce8\u5c04\u4ea7\u54c1\uff0c\u5982\u897f\u4e01\u7898\u542b\u7247\u3001\u5421\u7f57\u6614\u5eb7\u3001\u87ba\u5185\u916f\u548c\u82ef\u4e19\u54cc\u6797\u7b49\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"<\/p>\n\n\n\n
\n

\u622a\u6b62\u76ee\u524d\uff0cFDA\u5df2\u7ecf\u6279\u51c6\u4e86\u6570\u5341\u79cd\u96be\u6eb6\u836f\u7269\u7684\u8f6f\u80f6\u56ca\u4ea7\u54c1\uff0c<\/span>\u5bf9\u4e8e\u96be\u6eb6\u836f\u6765\u8bf4\uff0c \u8f6f\u80f6\u56ca\u662f\u4e00\u79cd\u7edd\u4f73\u7684\u589e\u6eb6\u7b56\u7565\u3002\u8f6f\u80f6\u56ca\u6700\u5927\u7684\u4f18\u52bf\u5728\u4e8e\u53ef\u4ee5\u586b\u5145\u6db2\u4f53\u7ec4\u5206\uff0c\u586b\u5145\u7269\u65e2\u53ef\u4ee5\u662f\u6cb9\u6027\u6eb6\u6db2\uff0c\u4e5f\u53ef\u4ee5\u662f\u5fae\u4e73\uff0c\u8fd8\u53ef\u4ee5\u662f\u4e59\u9187\u6eb6\u6db2\u7b49\u7b49\u3002\u96be\u6eb6\u6027\u836f\u7269\u5728\u4e59\u9187\u3001\u6cb9\u6216\u5fae\u4e73\u4e2d\u7684\u6eb6\u89e3\u5ea6\u53ef\u8fbe\u6c34\u4e2d\u6eb6\u89e3\u5ea6\u7684\u51e0\u500d\u3001\u51e0\u5341\u500d\u3001\u751a\u81f3\u6210\u767e\u4e0a\u5343\u500d\uff0c\u53ef\u4ee5\u6709\u6548\u89e3\u51b3\u6c34\u4e0d\u6eb6\u6027\u95ee\u9898\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

4.1\u8f6f\u80f6\u56ca\u5236\u5907<\/span><\/strong><\/p>\n\n\n\n
\n

\u76ee\u524d\u5de5\u4e1a\u4e0a\u5e38\u91c7\u7528\u6ef4\u5236\u6cd5\u548c\u538b\u5236\u6cd5\u5236\u5907\u8f6f\u80f6\u56ca\uff0c\u8fd9\u4e24\u79cd\u65b9\u6cd5\u5236\u5907\u5de5\u827a\u90fd\u6bd4\u8f83\u7b80\u5355\u3002\u6ef4\u5236\u6cd5\u662f\u56ca\u58f3\u6750\u8d28\u6eb6\u6db2\u4e0e\u836f\u6db2\u5206\u522b\u5728\u53cc\u5c42\u6ef4\u5934\u7684\u5185\u5916\u4fa7\u4ee5\u4e0d\u540c\u901f\u5ea6\u6ef4\u51fa\uff0c \u5f85\u5305\u88f9\u5b8c\u6210\u540e\u6ef4\u5165\u51b7\u5374\u6db2\u4e2d\u5373\u5f97\uff0c\u800c\u538b\u5236\u6cd5\u662f\u5148\u5c06\u56ca\u6750\u5236\u6210\u8584\u5e26\uff0c\u518d\u5c06\u836f\u7269\u7f6e\u4e8e\u4e24\u5c42\u8584\u5e26\u95f4\u538b\u5236\u800c\u6210\u3002\u8fd9\u4e24\u79cd\u65b9\u6cd5\u5de5\u827a\u7b80\u5355\uff0c\u5bb9\u6613\u63a7\u5236\uff0c\u4f46\u56ca\u6750\u662f\u8f6f\u80f6\u56ca\u6210\u8d25\u7684\u5173\u952e\u3002\u76ee\u524d\u56fd\u5185\u7684\u5927\u90e8\u5206\u8f6f\u80f6\u56ca\u4ea7\u54c1\u56ca\u58f3\u8001\u5316\u90fd\u6bd4\u8f83\u4e25\u91cd\uff0c\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u5d29\u89e3\u5ef6\u8fdf\u662f\u975e\u5e38\u5e38\u89c1\u7684\u73b0\u8c61<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

4.2 \u8f6f\u80f6\u56ca\u5185\u5bb9\u7269\u7684\u5236\u5907<\/span><\/strong><\/p>\n\n\n\n
\n

\u4eceFDA\u6279\u51c6\u7684\u4ea7\u54c1\u6765\u770b\uff0c\u8f6f\u80f6\u56ca\u586b\u5145\u7269\u4ee5\u5fae\u4e73\u5242\u5c45\u591a\u3002\u5fae\u4e73\u5242\u672c\u8eab\u4e5f\u662f\u4e00\u79cd\u826f\u597d\u7684\u589e\u6eb6\u624b\u6bb5\uff0c\u4e0e\u4e9a\u5fae\u4e73\u6240\u4e0d\u540c\u7684\u662f\uff0c\u5fae\u4e73\u662f\u70ed\u529b\u5b66\u7a33\u5b9a\u7cfb\u7edf\uff0c\u7c92\u5f84\u591a\u5728100\u5fae\u7c73\u4ee5\u4e0b\uff0c\u800c\u4e14\u5236\u5907\u662f\u4e0d\u9700\u8981\u5f3a\u5927\u7684\u673a\u68b0\u80fd\u8fdb\u884c\u5206\u6563\u3002\u6b63\u56e0\u4e3a\u6b64\uff0c\u5fae\u4e73\u9700\u8981\u4f7f\u7528\u5927\u91cf\u7684\u8868\u9762\u6d3b\u6027\u5242\u6765\u964d\u4f4e\u8868\u9762\u5f20\u529b\uff0c\u800c\u8868\u9762\u6d3b\u6027\u5242\u964d\u4f4e\u4e86\u4f53\u7cfb\u8868\u9762\u5f20\u529b\u7684\u540c\u65f6\uff0c \u4e5f\u80fd\u589e\u52a0\u836f\u7269\u7684\u6eb6\u89e3\u5ea6\u3002\u4e5f\u5c31\u662f\u8bf4\u4e0d\u80fd\u6eb6\u89e3\u5728\u6cb9\u76f8\u91cc\u7684\u836f\u7269\u4e5f\u80fd\u901a\u8fc7\u80f6\u675f\u7684\u539f\u7406\u8fdb\u884c\u589e\u6eb6\u3002\u9664\u4e86\u5fae\u4e73\u5242\u5916\uff0c\u8f6f\u80f6\u56ca\u7684\u5185\u5bb9\u7269\u8fd8\u5305\u62ec\u4e59\u9187\u6eb6\u6db2\uff0c\u6cb9\u6027\u6eb6\u6db2\u7b49\u7b49\u3002<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

4.3 \u8f6f\u80f6\u56ca\u7684\u5e94\u7528<\/span><\/strong><\/p>\n\n\n\n
\n

\u8f6f\u80f6\u56ca\u6700\u5927\u7684\u4f18\u52bf\u5728\u4e8e\u80fd\u5c06\u6db2\u4f53\u836f\u7269\u56fa\u4f53\u5316\uff0c\u64cd\u4f5c\u5de5\u827a\u7b80\u5355\uff0c\u6240\u4ee5\u8f6f\u80f6\u56ca\u662f\u6700\u5ec9\u4ef7\uff0c\u6700\u6709\u6548\u7684\u589e\u6eb6\u65b9\u5f0f\u3002\u76ee\u524dFDA\u5df2\u7ecf\u6279\u51c6\u4e86\u6570\u5341\u79cd\u8f6f\u80f6\u56ca\u836f\u7269\uff0c\u56fd\u5185\u7684\u8f6f\u80f6\u56ca\u4ea7\u54c1\u4e5f\u662f\u968f\u5904\u53ef\u89c1\uff0c\u4f46\u56fd\u5185\u7684\u8f6f\u80f6\u56ca\u76f8\u8f83\u56fd\u5916\u8fd8\u662f\u5177\u6709\u4e0d\u5c0f\u7684\u5dee\u8ddd\uff0c\u4e3b\u8981\u5dee\u8ddd\u5c31\u662f\u56ca\u6750\u7684\u8001\u5316\u95ee\u9898\uff0c\u56ca\u6750\u7684\u8001\u5316\u5927\u5927\u63d0\u9ad8\u4e86\u836f\u7269\u7684\u6d41\u901a\u6210\u672c\uff0c\u662f\u9650\u5236\u8f6f\u80f6\u56ca\u5e94\u7528\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 FDA\u6279\u51c6\u7684\u3001\u4f7f\u7528\u8f6f\u80f6\u56ca\u589e\u6eb6\u4ea7\u54c1\uff08\u90e8\u5206\uff09\u30101\u3011<\/span><\/p>\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Omega-3-Carboxylic  Acids<\/td>\nEpanova<\/td>\n2014<\/td>\n<\/tr>\n
Nintedanib  Esylate<\/td>\nOfev<\/td>\n2014<\/td>\n<\/tr>\n
Netupitant;  Palonosetron<\/td>\nAkynzeo<\/td>\n2014<\/td>\n<\/tr>\n
Omega-3-Acid  Ethyl Esters<\/td>\nOmtryg<\/td>\n2014<\/td>\n<\/tr>\n
Isotretinoin<\/td>\nAbsorica<\/td>\n2012<\/td>\n<\/tr>\n
Enzalutamide<\/td>\nXtandi<\/td>\n2012<\/td>\n<\/tr>\n
Dutasteride,  Tamsulosin<\/td>\nJalyn<\/td>\n2010<\/td>\n<\/tr>\n
Diclofenac  Potassium<\/td>\nZipsor<\/td>\n2009<\/td>\n<\/tr>\n
Palonosetron<\/td>\nAloxi<\/td>\n2008<\/td>\n<\/tr>\n
Topotecan<\/td>\nHycamtin<\/td>\n2007<\/td>\n<\/tr>\n
Levothyroxine  Sodium<\/td>\nTirosint<\/td>\n2006<\/td>\n<\/tr>\n
Lubiprostone<\/td>\nAmitiza<\/td>\n2006<\/td>\n<\/tr>\n
Paricalcitol<\/td>\nZemplar<\/td>\n2005<\/td>\n<\/tr>\n
Tipranavir<\/td>\nAptivus<\/td>\n2005<\/td>\n<\/tr>\n
Dutasteride<\/td>\nAvodart<\/td>\n2001<\/td>\n<\/tr>\n
Lopinavir,Ritonavir<\/td>\nKaletra<\/td>\n2000<\/td>\n<\/tr>\n
Doxercalciferol<\/td>\nHectorol<\/td>\n1999<\/td>\n<\/tr>\n
Ritonavir<\/td>\nNorvir<\/td>\n1999<\/td>\n<\/tr>\n
Progesterone<\/td>\nPrometrium<\/td>\n1998<\/td>\n<\/tr>\n
Cyclosporine<\/td>\nNeoral<\/td>\n1995<\/td>\n<\/tr>\n
Tretinoin<\/td>\nVesanoid<\/td>\n1995<\/td>\n<\/tr>\n
Cyclosporine<\/td>\nSandimmune<\/td>\n1990<\/td>\n<\/tr>\n
Lamprene<\/td>\nLamprene<\/td>\n1986<\/td>\n<\/tr>\n
Dronabinol<\/td>\nMarinol<\/td>\n1985<\/td>\n<\/tr>\n
Isotretinoin<\/td>\nAccutane<\/td>\n1982<\/td>\n<\/tr>\n
Calcitriol<\/td>\nRocaltrol<\/td>\n1978<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7b2c\u4e94\u7ae0 \u8102\u8d28\u4f53<\/span><\/p>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"5.1<\/span><\/strong>\u8102\u8d28\u4f53\u7684\u5b9a\u4e49<\/span><\/strong><\/span><\/p>\n\n\n\n
\n

<\/span><\/span><\/p>\n

\u6839\u636eFDA\u6307\u5357\uff0c\u8102\u8d28\u4f53\u662f\u7531\u5355\u4e2a\u4e24\u6027\uff08\u5982\u78f7\u8102\uff09\u53cc\u5206\u5b50\u5c42\u5305\u88f9\u4e00\u4e2a\uff0c\u548c\/\u6216\u591a\u4e2a\u4e24\u6027\u53cc\u5206\u5b50\u5c42\u5206\u9694\u4e00\u7cfb\u5217\u540c\u5fc3\u4e0d\u8fde\u7eed\u7684\u591a\u4e2a\u6c34\u6027\u9694\u5ba4\u800c\u5f62\u6210\u7684\u5fae\u578b\u6ce1\u56ca\uff0c\u836f\u7269\u53ef\u4ee5\u5305\u5c01\u5728\u6c34\u6027\u9694\u5ba4\u5185\uff0c\u4e5f\u53ef\u4ee5\u5b58\u5728\u8102\u8d28\u53cc\u5206\u5b50\u5c42\u95f4\u3002\u5236\u5907\u8102\u8d28\u4f53\u7684\u76ee\u7684\u9664\u4e86\u83b7\u5f97\u9776\u5411\u91ca\u836f\u7279\u6027\u5916\uff0c\u589e\u52a0\u836f\u7269\u7684\u6eb6\u89e3\u5ea6\u4e5f\u662f\u836f\u7269\u5f00\u53d1\u8005\u6240\u6700\u6c42\u7684\u76ee\u6807\uff0c\u5982\u6297\u764c\u836f\u4f9d\u7acb\u66ff\u5eb7\u8102\u8d28\u4f53\u3001\u7d2b\u6749\u9187\u8102\u8d28\u4f53\uff0c\u9547\u75db\u836f\u5417\u5561\u8102\u8d28\u4f53\u7b49\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

5.2<\/span><\/strong>\u8102\u8d28\u4f53\u7684\u5236\u5907<\/span><\/strong><\/p>\n\n\n\n
\n

<\/span><\/p>\n

\u8102\u8d28\u4f53\u5b9e\u9a8c\u5ba4\u5236\u5907\u65b9\u6cd5\u8f83\u591a\uff0c\u5982\u8584\u819c\u5206\u6563\u6cd5\uff0c\u590d\u4e73\u6cd5\uff0c\u4e59\u9187\u6ce8\u5165\u6cd5\u7b49\u7b49\uff0c\u4f46\u8102\u8d28\u4f53\u4ea7\u4e1a\u5316\u58c1\u5792\u8fdc\u9ad8\u4e8e\u4e00\u822c\u5242\u578b\uff0cFDA\u6279\u51c6\u7684\u8102\u8d28\u4f53\u836f\u54c1\u5c48\u6307\u53ef\u6570\uff0c\u6c89\u6dc0\u6210\u5b8c\u6574\u6280\u672f\u4f53\u7cfb\u7684\u9996\u63a8DepoFoam\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5417\u5561\u8102\u8d28\u4f53<\/span><\/strong><\/p>\n\n\n\n
\n

<\/span><\/p>\n

\u5417\u5561\u8102\u8d28\u4f53\u662f\u4f7f\u7528DepoFoam\u6280\u672f\u5236\u5907\u7684\u4e00\u79cd\u8102\u8d28\u4f53\uff0c2004\u5e74\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\u3002\u76ee\u524d\u5417\u5561\u8102\u8d28\u4f53\u5df2\u7ecf\u9000\u5e02\uff0c\u9664\u5417\u5561\u8102\u8d28\u4f53\u5916\uff0c\u4f7f\u7528\u6b64\u6280\u672f\u836f\u54c1\u8fd8\u5305\u62ecDepoCyt\uff08\u963f\u7cd6\u80de\u82f7\uff09\u548cEXPAREL\uff08\u5e03\u6bd4\u5361\u56e0\uff09\uff0c\u5206\u522b\u4e8e1999\u5e74\u548c2011\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\u3002DepoFoam\u662f\u4e00\u79cd\u7f13\u91ca\u8102\u8d28\u4f53\u6280\u672f\uff0c\u662f\u7f8e\u56fd\u79d1\u5b66\u5bb6\u5728\u4e0a\u4e16\u7eaa80\u5e74\u4ee3\u4f7f\u7528\u590d\u4e73\u6cd5\u5236\u5907\u8102\u8d28\u4f53\u4e00\u79cd\u7684\u4e00\u79cd\u6280\u672f\uff0c\u7ecf\u8fc7\u591a\u5e74\u7684\u53d1\u5c55\uff0c\u5df2\u5f62\u6210\u4e86\u5b8c\u6574\u7684\u5de5\u4e1a\u5316\u6280\u672f\u4f53\u7cfb\u3002DepoFoam\u5236\u5907\u7684\u8102\u8d28\u4f53\u662f\u4e00\u79cd\u591a\u5ba4\u8102\u8d28\u4f53\uff0c\u6839\u636ePacira\u7684\u4ecb\u7ecd\uff0cDepoFoam\u6280\u672f\u53ef\u8f7d\u5165\u591a\u80bd\u3001\u86cb\u767d\u548c\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u5b9e\u73b01-30\u5929\u7684\u7f13\u6162\u91ca\u653e\u836f\u7269\u3002\u8fd1\u5e74\u6765EXPAREL\u9ad8\u901f\u589e\u957f\uff0c2015\u5e74EXPAREL\u9500\u552e\u989d\u5df2\u8fbe2.4\u4ebf\u7f8e\u5143\uff0c\u6709\u5206\u6790\u5e08\u9884\u8ba1\u8be5\u4ea7\u54c1\u7684\u9500\u552e\u989d\u5cf0\u503c\u53ef\u8fbe10\u4ebf\u7f8e\u5143\u3002\u5728\u4e34\u5e8a\u9636\u6bb5\u4f7f\u7528\u8be5\u6280\u672f\u7684\u4ea7\u54c1\u8fd8\u5305\u62ec\uff0c\u5982\u963f\u7c73\u5361\u661f\u3001\u7532\u6c28\u558b\u5464\u3001\u5e86\u5927\u9709\u7d20\u3001\u987a\u94c2\u3001myelopoietin\u3001progenipoietin\u7b49\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d2b\u6749\u9187\u8102\u8d28\u4f53<\/span><\/strong><\/p>\n\n\n\n
\n

<\/span><\/p>\n

\u7d2b\u6749\u9187\u8102\u8d28\u4f53\u662f\u6211\u56fd\u9996\u521b\u4ea7\u54c1\uff0c\u7531\u5357\u4eac\u7eff\u53f6\u5f00\u53d1\u9500\u552e\uff0c\u5546\u54c1\u540d\u4e3a\u529b\u6251\u7d20\uff0c\u4e8e2003\u5e74\u83b7\u6279CFDA\u6279\u51c6\u3002\u529b\u6251\u7d20\u6210\u529f\u89e3\u51b3\u4e86\u7d2b\u6749\u9187\u6eb6\u89e3\u5ea6\u4f4e\u7684\u95ee\u9898\uff0c\u89e3\u9664\u6eb6\u5a92\u5f15\u8d77\u7684\u8d85\u654f\u98ce\u9669\uff0c\u660e\u663e\u964d\u4f4e\u4e86\u7d2b\u6749\u9187\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u63d0\u9ad8\u4e86\u60a3\u8005\u4f9d\u4ece\u6027\u3002\u5e02\u573a\u65b9\u9762\u529b\u6251\u7d20\u83b7\u5f97\u5f88\u5927\u7684\u6210\u529f\u30022010\u5e74\u4ee5\u540e\uff0c\u9500\u552e\u989d\u9ad8\u901f\u589e\u957f\uff0c2013\u5e74\u7684\u9500\u552e\u989d\u4e3a8.5\u4ebf\u5143\uff0c 2014\u5e74\u7eff\u53f6\u601d\u79d1\u8102\u8d28\u4f53\u4ea7\u91cf\u8fbe150\u4e07\u652f\uff0c2015\u5e74\u7684\u9500\u552e\u989d\u8d85\u8fc710\u4ebf\u5143\uff0c\u6210\u4e3a\u6211\u56fd\u6297\u764c\u836f\u7b2c\u4e00\u5927\u54c1\u79cd\u3002<\/span><\/p>\n

<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

5.3<\/span><\/strong>\u8102\u8d28\u4f53\u7684\u5e94\u7528<\/span><\/strong><\/p>\n\n\n\n
\n

<\/span><\/p>\n

\u8102\u8d28\u4f53\u72ec\u7279\u7684\u91ca\u836f\u7279\u5f81\uff0c\u8d4b\u4e88\u8102\u8d28\u4f53\u7684\u7279\u6027\u4e0d\u6b62\u662f\u589e\u6eb6\uff0c\u8102\u8d28\u4f53\u8fd8\u53ef\u4ee5\u8d4b\u4e88\u7f13\u91ca\u548c\u9776\u5411\u7684\u751f\u7269\u836f\u5242\u5b66\u7279\u6027\uff0c\u662f\u6700\u7406\u60f3\u7684\u91ca\u836f\u7cfb\u7edf\u4e4b\u4e00\uff0c2015\u5e74\u5168\u7403\u8102\u8d28\u4f53\u9500\u552e\u603b\u989d\u8fd113\u4ebf\u7f8e\u5143\uff0c\u6211\u56fd18\u4ebf\u5143\u4eba\u6c11\u5e01\u3002\u8fd1\u5e74\u6765\u8102\u8d28\u4f53\u836f\u7269\u7684\u5e02\u573a\u6b63\u5728\u5d1b\u8d77\uff0cFDA\u6388\u4e88VYXEOS\uff08\u963f\u7cd6\u80de\u82f7+\u67d4\u7ea2\u9709\u7d20\uff09\u548cArikayce\uff08\u963f\u5361\u7c73\u661f\uff09\u7a81\u7834\u6027\u7597\u6cd5\u8fdb\u4e00\u6b65\u8bf4\u660e\u8102\u8d28\u4f53\u4ea7\u54c1\u5f00\u53d1\u6f5c\u529b\u5de8\u5927\u3002<\/span><\/p>\n

<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"
<\/span><\/strong><\/p>\n

\u7b2c\u516d\u7ae0<\/span>\u4e73\u5242<\/span><\/p>\n

6.1<\/span><\/strong>\u4e73\u5242\u6982\u5ff5<\/span><\/strong><\/p>\n\n\n\n
\n

\u4e73\u5242\u662f\u4e92\u4e0d\u76f8\u6eb6\u7684\u4e24\u76f8\u6db2\u4f53\u7ecf\u4e73\u5316\u800c\u5f62\u6210\u7684\u975e\u5747\u76f8\u6db2\u4f53\u5206\u6563\u4f53\u7cfb\uff0c\u4e0e\u8102\u8d28\u4f53\u6240\u4e0d\u540c\u7684\u662f\uff0c\u4e73\u5242\u7684\u754c\u9762\u819c\u662f\u5355\u5206\u5b50\u5c42\uff0c\u4eb2\u6cb9\u57fa\u4f38\u5411\u6cb9\u76f8\uff0c\u4eb2\u6c34\u57fa\u4f38\u5411\u6c34\u76f8\uff0c\u662f\u7403\u5f62\u7684\u7ed3\u6784\u3002\u5bf9\u4e8e\u8102\u6eb6\u6027\u836f\u7269\u6765\u8bf4\uff0c\u4e73\u5242\u662f\u4e00\u79cd\u7406\u60f3\u589e\u6eb6\u7b56\u7565\uff0c\u5bf9\u4e8e\u6cb9\u6c34\u5747\u4e0d\u6eb6\u7684\u836f\u7269\uff0c\u4e73\u5242\u7684\u589e\u6eb6\u6548\u679c\u6709\u9650\u3002\u4e73\u5242\u53ef\u6ce8\u5c04\u4e5f\u53ef\u53e3\u670d\uff0c\u5bf9\u4e8e\u53e3\u670d\u4e73\u5242\uff0c\u53ef\u4ee5\u5236\u6210\u81ea\u4e73\u5316\u7cfb\u7edf\u6216\u5fae\u4e73\uff0c\u800c\u6ce8\u5c04\u4e73\u5242\u5f80\u5f80\u5bf9\u8868\u9762\u6d3b\u6027\u5242\u53ca\u5176\u7528\u91cf\u8981\u6c42\u4e25\u683c\uff0c\u4e00\u822c\u5236\u6210\u4e9a\u5fae\u4e73\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"<\/p>\n

6.2 <\/span><\/strong>\u4e73\u5242\u7684\u5236\u5907<\/span><\/strong><\/p>\n\n\n\n
\n

<\/span><\/p>\n

\u5fae\u4e73\u548c\u81ea\u4e73\u5316\u7cfb\u7edf\u56e0\u542b\u6709\u5927\u91cf\u7684\u8868\u9762\u6d3b\u6027\u5242\u53ef\u4ee5\u5c06\u8868\u9762\u80fd\u4e0b\u964d\u5230\u4e34\u754c\u503c\u4ee5\u4e0b\u5f62\u6210\u70ed\u529b\u5b66\u8db3\u7a33\u5b9a\u7684\u7cfb\u7edf\uff0c\u5236\u5907\u5de5\u827a\u6bd4\u8f83\u7b80\u5355\uff0c\u800c\u6ce8\u5c04\u4e73\u5242\u56e0\u4e25\u683c\u63a7\u5236\u8868\u9762\u6d3b\u6027\u5242\u7684\u7528\u91cf\u65e0\u6cd5\u5f62\u6210\u70ed\u529b\u5b66\u7a33\u5b9a\u7684\u4f53\u7cfb\uff0c\u5236\u5907\u5de5\u827a\u6bd4\u8f83\u590d\u6742\u3002\u4e00\u822c\u5de5\u4e1a\u4e0a\u4f7f\u7528\u78f7\u8102\u4f5c\u4e3a\u6ce8\u5c04\u4e73\u5242\u7684\u8868\u9762\u6d3b\u6027\u5242\uff0c\u7528\u91cf\u4e00\u822c\u57281%-2%\u4e4b\u95f4\uff0c\u5728\u4e00\u4e2a\u5408\u9002\u7684\u6e29\u5ea6\u4e0b\u5c06\u78f7\u8102\u6eb6\u4e8e\u6cb9\u76f8\u518d\u4e0e\u6c34\u76f8\u8fdb\u884c\u9ad8\u526a\u5207\u4e73\u5316\u5236\u6210\u521d\u4e73\uff0c\u521d\u4e73\u518d\u7ecf\u8fc73-5\u6b21\u7684\u9ad8\u538b\u5747\u8d28\u5373\u53ef\u5236\u5f97\u3002\u6ce8\u5c04\u4e73\u5242\u7684\u5236\u5907\uff0c\u539f\u6599\u548c\u6761\u4ef6\u7684\u63a7\u5236\u662f\u5173\u952e\uff0c\u7a0d\u5fae\u7684\u5dee\u5f02\u4fbf\u53ef\u5f15\u8d77\u4ea7\u54c1\u5b9e\u8d28\u6027\u7684\u533a\u522b\uff0c\u6bd4\u5982\u7c92\u5f84\u53d8\u5316\u3001\u706d\u83cc\u7834\u4e73\u3001\u7a33\u5b9a\u6027\u53d8\u5316\u7b49\u7b49\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

6.3<\/span><\/strong>\u4e73\u5242\u7684\u5e94\u7528<\/span><\/strong><\/p>\n\n\n\n
\n

\u4e73\u5242\u662f\u4e00\u79cd\u4f18\u826f\u7684\u8f7d\u836f\u7cfb\u7edf\uff0c\u4e5f\u662f\u4e00\u79cd\u7406\u60f3\u7684\u96be\u6eb6\u836f\u89e3\u51b3\u7b56\u7565\u3002\u76ee\u524d\u4e0a\u5e02\u7684\u4ea7\u54c1\u5df2\u7ecf\u6709\u6570\u5341\u4e2a\uff0c\u5176\u4e2d\u53e3\u670d\u4e73\u5242\u5360\u7edd\u5927\u591a\u6570\u3002\u53e3\u670d\u5fae\u4e73\u548c\u8f6f\u80f6\u56ca\u662f\u7edd\u4f73\u7684\u642d\u914d\uff0c\u4e0d\u4f46\u53ef\u4ee5\u5b9e\u73b0\u5f88\u597d\u7684\u589e\u6eb6\uff0c\u8fd8\u80fd\u6db2\u4f53\u5236\u5242\u56fa\u4f53\u5316\uff0c\u65b9\u4fbf\u643a\u5e26\u3001\u8fd0\u8f93\u548c\u4f7f\u7528\u3002ICH\u56fd\u5bb6\u6279\u51c6\u7684\u6ce8\u5c04\u4e73\u5242\u4e0d\u591a\uff0c\u9664\u4e86\u591a\u897f\u4ed6\u8d5b\u5916\uff0c\u5176\u5b83\u4ea7\u54c1\u57fa\u672c\u662f\u8f7d\u836f\u8102\u80aa\u4e73\u3002\u4e2d\u56fd\u662f\u6ce8\u5c04\u4e73\u5242\u6700\u4e3a\u666e\u53ca\u7684\u56fd\u5bb6\uff0c2015\u5e74\u6211\u56fd\u6ce8\u5c04\u4e73\u5242\u9500\u552e\u603b\u989d\u8fbe80\u4ebf\u5143\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"<\/span>
<\/p>\n

<\/span><\/p>\n


<\/p>\n

\n
\n
<\/section>\n

<\/section>\n<\/section>\n
\n
\n
\n
\n
<\/span><\/span><\/span><\/section>\n
<\/span><\/span><\/span><\/section>\n<\/section>\n
\u7ed3\u8bed<\/span><\/section>\n
\n
<\/span><\/span><\/span><\/section>\n
<\/span><\/span><\/span><\/section>\n<\/section>\n

<\/span><\/em><\/strong><\/span><\/section>\n

\n
\n

\u9664\u6b64\u4ee5\u5916\uff0c\u56fd\u5916\u5df2\u7ecf\u5f00\u53d1\u51fa\u591a\u79cd\u96be\u6eb6\u836f\u5236\u5242\u6280\u672f\uff0c\u5982\u9ad8\u5206\u5b50\u80f6\u675f\u3001\u7eb3\u7c73\u7c92\u7b49\uff0c\u8fd9\u4e9b\u6280\u672f\u5236\u5907\u96be\u5ea6\u5927\uff0c\u4e0a\u5e02\u4ea7\u54c1\u5c11\uff0c\u672c\u6587\u4e0d\u518d\u8be6\u7ec6\u4ecb\u7ecd\u3002\u9664\u4e86\u5236\u5242\u624b\u6bb5\u5916\uff0c\u5c06\u836f\u7269\u5236\u6210\u76d0\u3001\u65e0\u5b9a\u578b\u6216PEG\u4fee\u9970\u4e5f\u662f\u6709\u6548\u7684\u96be\u6eb6\u836f\u7269\u89e3\u51b3\u7b56\u7565\uff0c\u8fd9\u4e9b\u6280\u672f\u867d\u597d\uff0c\u7b14\u8005\u5c06\u5b83\u7559\u4e2a\u5408\u6210\u4eba\u5458\u6765\u4ecb\u7ecd\u3002<\/span><\/p>\n

\u6211\u56fd\u7531\u4e8e\u5386\u53f2\u7684\u539f\u56e0\uff0c\u73b0\u4ee3\u5316\u5236\u5242\u7814\u7a76\u8d77\u6b65\u8f83\u665a\uff0c\u4f46\u5728\u5927\u91cf\u7684\u96be\u6eb6\u578b\u836f\u7269\u9762\u524d\uff0c\u53d1\u5c55\u8fd9\u4e9b\u6280\u672f\u662f\u5fc5\u7136\u7684\u8d8b\u52bf\u3002\u5728\u672a\u6765\u7684\u7814\u53d1\u957f\u6cb3\u4e2d\uff0c\u6211\u56fd\u5236\u5242\u5de5\u4f5c\u8005\u5c06\u9762\u4e34\u5de8\u5927\u7684\u6311\u6218\uff0c\u540c\u65f6\u4e5f\u662f\u6211\u4eec\u6700\u597d\u7684\u673a\u9047\u3002\u5236\u5242\u5de5\u4f5c\u8005\u5e94\u653e\u773c\u56fd\u5916\uff0c\u4f46\u4e5f\u4e0d\u80fd\u62d8\u6ce5\u4e8e\u56fd\u5916\u7684\u6210\u578b\u6280\u672f\uff0c\u5927\u80c6\u5f00\u52a8\u8111\u7b4b\uff0c\u53d1\u660e\u81ea\u5df1\u7684\u7279\u8272\u6280\u672f\u624d\u662f\u63d0\u9ad8\u8eab\u4ef7\u7684\u786c\u9053\u7406\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

                         <\/span><\/p>\n

\u30101\u3011\u6b64\u7c7b\u578b\u4ea7\u54c1\u4f17\u591a\uff0c\u7b14\u8005\u5728\u6b64\u4e0d\u518d\u4e00\u4e00\u5217\u4e3e\uff0c\u6b22\u8fce\u8bfb\u8005\u7559\u8a00\u8865\u5145<\/span><\/p>\n


<\/span><\/p>\n

\u53c2\u8003\u6587\u732e\uff081-3\u7ae0\uff09<\/span><\/p>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"
<\/p>\n

\u53c2\u8003\u6587\u732e\uff084-6\u7ae0\uff09<\/p>\n

\"\u5728\u7814\u836f\u7269\u4e2d\u96be\u6eb6\u836f\u9ad8\u8fbe90%\uff0c\u4f60\u8be5\u5982\u4f55\u53bb\u641e\u5b9a\uff1f\"<\/p>\n


<\/p>\n

\u6392\u7248\uff1a\u6587\u7af9<\/span>
<\/p>\n

\n


<\/p>\n

\n
\n

\u57f9\u8bad\u548c\u4f1a\u8bae\uff1a<\/p>\n