{"id":48279,"date":"2018-09-21T01:00:00","date_gmt":"2018-09-26T01:47:53","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e8%87%b4%e5%8a%9b%e4%ba%8e%e5%bc%80%e5%8f%91%e6%96%b0%e5%9e%8b%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e7%96%97%e6%b3%95%e7%9a%84affimed\/"},"modified":"2018-09-26T09:47:56","modified_gmt":"2018-09-26T01:47:56","slug":"%e8%87%b4%e5%8a%9b%e4%ba%8e%e5%bc%80%e5%8f%91%e6%96%b0%e5%9e%8b%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e7%96%97%e6%b3%95%e7%9a%84affimed","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/48279\/","title":{"rendered":"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img     style=\"\" class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537926473.jpg\" alt=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\" title=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\"  \/><\/p>\n<section class=\"article-abstract\" style=\"padding-bottom: 20px;white-space: normal;font-size: 14px;\">\n<hr style=\"border-top-style: dotted;border-top-color: rgb(140, 139, 139);\"  \/>\n<p>2018\u5e748\u6708\uff0cAffimed\u4e0eGenentech\u8fbe\u6210\u4e86\u9ad8\u8fbe50\u4ebf\u7f8e\u5143\u7684\u5408\u4f5c\uff0c\u5171\u540c\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\uff0c\u4ee5\u6fc0\u53d1\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u6cbb\u7597\u6f5c\u529b\u3002Affimed\u5f3a\u5927\u7684\u6280\u672f\u5e73\u53f0\u548c\u575a\u5b9e\u7684\u4e13\u5229\u7ec4\u5408\u4f7f\u5176\u5728\u6fc0\u70c8\u7684\u5e02\u573a\u7ade\u4e89\u4e2d\u9886\u5148\u4e00\u6b65\u5e76\u8d62\u5f97\u4e86\u53ef\u9760\u7684\u5408\u4f5c\u4f19\u4f34\u3002<\/p>\n<p><br  \/><\/section>\n<section class=\"article-header\" style=\"padding-bottom: 30px;white-space: normal;text-align: center;font-family: Arial, \u9ed1\u4f53;\">\n<section class=\"article-title\" style=\"font-size: 24px;\">\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed<\/section>\n<section class=\"article-by-icon\" style=\"padding-top: 10px;padding-bottom: 10px;\"><img loading=\"lazy\" class=\"\"     height=\"25px\" width=\"25px\" style=\"margin-right: auto;margin-left: auto;display: block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537926474.png\" alt=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\" title=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\"  \/><\/section>\n<section class=\"article-by\" style=\"font-size: 14px;font-style: italic;\">by<\/section>\n<section class=\"article-author\" style=\"font-size: 16px;\">TiPLab \u6728\u6843<\/section>\n<\/section>\n<section class=\"content\" style=\"white-space: normal;\">\n<section class=\"h1-prefix\" style=\"padding-top: 20px;text-align: center;font-size: 18px;color: rgb(218, 18, 42);\">\u25bc<\/section>\n<h1 style=\"padding-bottom: 20px;font-size: 18px;text-align: center;font-family: Arial, \u9ed1\u4f53;color: rgb(218, 18, 42);\">\u62e5\u6709\u72ec\u7279ROCK\u5e73\u53f0\u6280\u672f\u7684Affimed<\/h1>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">Affimed\u6210\u7acb\u4e8e2000\u5e74\uff0c\u5176\u6838\u5fc3\u6280\u672f\u6765\u6e90\u4e8e\u4f4d\u4e8e\u6d77\u5fb7\u5821\u7684\u5fb7\u56fd\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3 (DKFZ)\u7684Melvyn Little\u6559\u6388\u5f00\u53d1\u7684\u5e73\u53f0\uff0c<strong style=\"color: rgb(218, 18, 42);\">\u81f4\u529b\u4e8e\u5f00\u53d1\u591a\u7279\u5f02\u6027\u6297\u4f53\uff0c\u5e76\u5229\u7528\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u6765\u6740\u4f24\u80bf\u7624\u7ec6\u80de<\/strong>\u3002\u76ee\u524d\uff0c\u57fa\u4e8e\u8be5\u6280\u672f\u5f00\u53d1\u7684\u4e24\u4e2a\u4ea7\u54c1\u5df2\u7ecf\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">ROCK<sup>\u00ae<\/sup>&nbsp;(Redirected Optimized Cell Killing\uff0c\u91cd\u5b9a\u5411\u4f18\u5316\u7ec6\u80de\u6740\u4f24)\u5e73\u53f0\u53ef\u4ee5\u5f00\u53d1\u4f18\u79c0\u7684\u56db\u4ef7\u591a\u7279\u5f02\u6027\u6297\u4f53\uff0c\u8fd9\u79cd<strong style=\"color: rgb(218, 18, 42);\">\u591a\u7279\u5f02\u6027\u6297\u4f53\u53ef\u4ee5\u62db\u52dfNK\u7ec6\u80de\u6216T\u7ec6\u80de\u5230\u80bf\u7624\u5468\u56f4\uff0c\u4ece\u800c\u5229\u7528\u5148\u5929\u514d\u75ab\u6216\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u4ee5\u5bf9\u6297\u764c\u75c7<\/strong>\uff0c\u800c\u4f20\u7edf\u7684\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u901a\u5e38\u662f\u5229\u7528\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf (\u5373T\u7ec6\u80de)\u6765\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002\u6b64\u5916\uff0c\u57fa\u4e8e\u5176\u6a21\u5757\u6027\u8bbe\u8ba1\uff0cROCK<sup>\u00ae<\/sup>\u5e73\u53f0\u53ef\u4ee5\u6839\u636e\u4e0d\u540c\u7684\u9002\u5e94\u75c7\u548c\u5fae\u73af\u5883\u5bf9\u6297\u4f53\u8fdb\u884c\u5de5\u7a0b\u5316\u5b9a\u5236\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">2009\u5e74\uff0cAffimed\u5728\u6377\u514b\u5efa\u7acb\u4e86\u5176\u5168\u8d44\u5b50\u516c\u53f8AbCheck\uff0c<strong style=\"color: rgb(218, 18, 42);\">\u4e13\u6ce8\u4e8e\u5168\u4eba\u6e90\u6297\u4f53\u7684\u7b5b\u9009\u548c\u4f18\u5316\uff0c\u81f4\u529b\u4e8e\u4f7f\u7528\u566c\u83cc\u4f53\u5c55\u793a\u3001\u9175\u6bcd\u5c55\u793a\u548c\u8ba1\u7b97\u673a\u5de5\u5177\u6765\u8bbe\u8ba1\u548c\u4f18\u5316\u6297\u4f53<\/strong>\uff0c\u4e3a\u5176\u5408\u4f5c\u4f19\u4f34\u63d0\u4f9b\u6700\u5148\u8fdb\u7684\u670d\u52a1\uff0c\u4e5f\u4e0d\u65ad\u4e3aAffimed\u63d0\u4f9b\u5019\u9009\u4ea7\u54c1\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u5176\u4e2d\uff0c<strong style=\"color: rgb(218, 18, 42);\">TandAb\u662f\u5229\u7528ROCK<sup>\u00ae<\/sup>\u5e73\u53f0\u5f00\u53d1\u7684\u4e00\u7c7b\u56db\u4ef7\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u5305\u542b\u56db\u4e2ascFv\u7ed3\u6784\u57df<\/strong>\uff0c\u7528\u4e8e\u6784\u5efaTandAb\u7684\u6297\u4f53\u53ef\u4ee5\u6765\u81eaIgG (\u4f8b\u5982\u9175\u6bcd\u5c55\u793a)\u6216\u6765\u81ea\u5355\u94feFv (\u4f8b\u5982\u566c\u83cc\u4f53\u5c55\u793a)\uff0cAffimed\u62e5\u6709\u8bbe\u8ba1\u548c\u6784\u5efa\u8fd9\u4e9b\u5206\u5b50\u7684\u4e13\u4e1a\u77e5\u8bc6\u548c\u7ecf\u9a8c\uff0c\u5e76\u4e3a\u5927\u91cf\u9776\u70b9\u5f00\u53d1\u4e86TandAb\u3002<\/p>\n<p><img class=\"\"     style=\"margin-right: auto;margin-left: auto;display: block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537926474.jpeg\" alt=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\" title=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\"  \/><\/p>\n<blockquote>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">1999\u5e74\uff0c\u4ee5Melvyn Little\u4f5c\u4e3a\u53d1\u660e\u4eba\uff0c\u5fb7\u56fd\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u9012\u4ea4\u4e86\u6d89\u53ca\u53cc\u7279\u5f02\u6027\u56db\u4ef7\u540c\u6e90\u4e8c\u805a\u4f53Fv\u6297\u4f53 (PCT\/DE1999\/001350)\uff0c\u8fdb\u5165\u7f8e\u56fd\u56fd\u5bb6\u9636\u6bb5\u7684\u7684\u6388\u6743\u4e13\u5229\u4e3aUS7129330B1\u3002\u8be5\u4e13\u5229\u5bb6\u65cf\u9884\u8ba1\u4e8e2019\u5e74\u5230\u671f\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">2002\u5e74\uff0cAffimed\u9012\u4ea4\u4e86\u6d89\u53ca\u591a\u805a\u4f53\u7ed3\u6784\u7684PCT\u56fd\u9645\u7533\u8bf7 (PCT\/EP2002\/010307)\uff0c\u5305\u542b\u4e24\u79cd\u6216\u66f4\u591a\u79cd\u76f8\u540c\u7684\u86cb\u767d\u8d28\u5355\u4f53\uff0c\u6bcf\u4e2a\u5355\u4f53\u5305\u542b\u81f3\u5c11\u56db\u4e2a\u53ef\u53d8\u7ed3\u6784\u57df\u3002\u5176\u8fdb\u5165\u7f8e\u56fd\u56fd\u5bb6\u9636\u6bb5\u7684\u4e13\u5229\u7533\u8bf7 (US20050079170A1)\u7ecf\u8fc7\u4e24\u6b21RCE (Request for continued examination)\u4ecd\u5904\u4e8e\u5ba1\u67e5\u9636\u6bb5\u3002PCT\/EP2002\/010307\u6ca1\u6709\u8fdb\u5165\u4e2d\u56fd\u56fd\u5bb6\u9636\u6bb5\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">2011\u5e74\uff0cAffimed\u9012\u4ea4\u4e86\u53e6\u4e00\u4e2aPCT\u56fd\u9645\u7533\u8bf7 (PCT\/EP2011\/062673)\uff0c\u8fdb\u5165\u4e2d\u56fd\u56fd\u5bb6\u9636\u6bb5\u7684\u6388\u6743\u4e13\u5229\u516c\u544a\u53f7\u4e3aCN103687879B\uff0c\u5176\u6743\u5229\u8981\u6c421\u4fdd\u62a4\u4e00\u79cd\u4e8c\u805a\u6297\u539f\u7ed3\u5408\u5206\u5b50\uff0c\u7531\u7b2c\u4e00\u591a\u80bd\u94fe\u548c\u7b2c\u4e8c\u591a\u80bd\u94fe\u6784\u6210\uff0c\u5176\u4e2d\u6bcf\u6761\u591a\u80bd\u94fe\u7684N-\u672b\u7aef\u5230C-\u672b\u7aef\u6309V<sub>L<\/sub>A-V<sub>H<\/sub>B-V<sub>L<\/sub>B-V<sub>H<\/sub>A\u7684\u987a\u5e8f\u6392\u5217\uff0c\u5e76\u9650\u5b9a\u4e86\u6297\u539f\u7ed3\u5408\u5206\u5b50\u7684\u8fde\u63a5\u65b9\u5f0f\uff0c\u4e0b\u56fe\u5c55\u793a\u4e86\u4e8c\u805a\u6297\u539f\u7ed3\u5408\u5206\u5b50\u7684\u5f62\u6210\u8fc7\u7a0b\u3002<strong style=\"color: rgb(218, 18, 42);\">CN103687879B\u5e76\u6ca1\u6709\u9650\u5b9a\u5177\u4f53\u7684\u7ed3\u5408\u4f4d\u70b9\uff0c\u662f\u4fdd\u62a4TandAb\u5e73\u53f0\u6280\u672f\u7684\u91cd\u8981\u4e13\u5229<\/strong>\u3002<\/p>\n<\/blockquote>\n<p><img class=\"\"     style=\"margin-right: auto;margin-left: auto;display: block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537926475.jpeg\" alt=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\" title=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\"  \/><\/p>\n<h2 style=\"margin-top: 5px;margin-bottom: 5px;padding: 5px 10px;font-family: Arial, \u9ed1\u4f53;border-width: 1px 1px 1px 3px;border-style: solid;border-color: rgb(41, 128, 185);line-height: 20px;\">\u901a\u8fc7\u7ed3\u5408CD16A\u62db\u52dfNK\u7ec6\u80de\u7684TandAb<\/h2>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">NK\u7ec6\u80de\u662f\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u91cd\u8981\u6210\u5458\u4e4b\u4e00\uff0c\u4e0d\u8fc7\u72e1\u733e\u7684\u80bf\u7624\u7ec6\u80de\u4f1a\u9003\u907fNK\u7ec6\u80de\u7684\u514d\u75ab\u76d1\u89c6\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0cAffimed\u72ec\u5bb6\u5f00\u53d1\u4e86\u9776\u5411NK\u7ec6\u80de\u8868\u9762CD16A\u7684TandAb\u6765\u6fc0\u53d1NK\u7ec6\u80de\u7684\u6740\u4f24\u6f5c\u529b\u3002<strong style=\"color: rgb(218, 18, 42);\">TandAb\u53ef\u4ee5\u540c\u65f6\u7ed3\u5408CD16A (\u5373Fc\u03b3RIIIA)\u548c\u80bf\u7624\u6297\u539f\uff0c\u4ece\u800c\u5c06NK\u7ec6\u80de\u91cd\u5b9a\u5411\u81f3\u80bf\u7624\u7ec6\u80de\u5468\u56f4\u6765\u53d1\u6325\u4f5c\u7528<\/strong>\u3002TandAb\u5bf9Fc\u03b3RIIIA\u7684\u7ed3\u5408\u4eb2\u548c\u529b\u53ef\u4ee5\u8fbe\u5230\u4e9a\u7eb3\u6469\u5c14\u7ea7\u522b\uff0c\u6bd4\u5e38\u89c4\u6297\u4f53\u7684\u4eb2\u548c\u529b\u5f3a\u7ea61000\u500d\u3002<\/p>\n<p><img class=\"\"     style=\"margin-right: auto;margin-left: auto;display: block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537926475-1.jpeg\" alt=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\" title=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\"  \/><\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u76ee\u524d\uff0c\u5927\u591a\u6570\u9776\u5411CD16\u7684\u6297\u4f53\u90fd\u4e0d\u80fd\u533a\u5206Fc\u03b3IIIA\u548cFc\u03b3IIIB\u4e9a\u578b (\u8868\u8fbe\u4e8e\u55dc\u4e2d\u6027\u7c92\u7ec6\u80de)\uff0c\u4f46Fc\u03b3IIIB\u4e9a\u578b\u4e0d\u80fd\u5f15\u53d1\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\uff0c\u5e76\u53ef\u80fd\u4f1a\u5f15\u53d1\u526f\u4f5c\u7528\uff0c\u56e0\u6b64\uff0c<strong style=\"color: rgb(218, 18, 42);\">\u7279\u5f02\u6027\u9776\u5411Fc\u03b3RIIIA\u7684TandAb\u662f\u5176\u6838\u5fc3\u6280\u672f\u4e4b\u4e00<\/strong>\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u4e3a\u6b64\uff0c2006\u5e74\uff0cAffimed\u9012\u4ea4\u4e86\u6d89\u53ca\u7ed3\u5408Fc\u03b3RIIIA\u7ed3\u5408\u5206\u5b50\u7684PCT\u56fd\u9645\u7533\u8bf7\uff0c\u5e76\u8fdb\u5165\u4e86US\u3001EP\u3001JP\u3001CN\u7b49\u56fd\u5bb6\u9636\u6bb5\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u6bd4\u5982\uff0c\u8fdb\u5165\u4e2d\u56fd\u56fd\u5bb6\u9636\u6bb5\u7684\u4e13\u5229\u7533\u8bf7CN101583625A (\u5c1a\u672a\u83b7\u5f97\u6388\u6743)\u7684\u6743\u5229\u8981\u6c421\u6d89\u53ca\uff1a<\/p>\n<blockquote>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u201c\u4e00\u79cd\u5bf9\u81f3\u5c11\u4e00\u79cd\u6297\u539f\u5177\u6709\u7279\u5f02\u6027\u7684\u7ed3\u5408\u5206\u5b50\uff0c\u5176\u4e2d\u6240\u8ff0\u81f3\u5c11\u4e00\u79cd\u6297\u539f\u662fFc\u03b3RIIIA\uff0c\u4e14\u6240\u8ff0\u7ed3\u5408\u5206\u5b50\u4e0d\u7279\u5f02\u6027\u7ed3\u5408\u4e8eFc\u03b3IIIB\u3002\u201d<\/p>\n<\/blockquote>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u8fdb\u5165\u7f8e\u56fd\u56fd\u5bb6\u9636\u6bb5\u7684\u6388\u6743\u4e13\u5229 (US9035026B2)\u7684\u6743\u5229\u8981\u6c421\u4e2d\u5bf9\u6297\u4f53\u7684\u53ef\u53d8\u533a\u6216CDR\u533a\u8fdb\u884c\u4e86\u9650\u5b9a\u3002\u5176\u5206\u6848\u7533\u8bf7\u4e5f\u83b7\u5f97\u4e86\u6388\u6743 (US9701750B2)\uff0c\u4fdd\u62a4\u4f7f\u7528\u7ed3\u5408Fc\u03b3RIIIA\u7684\u6297\u4f53\u8bf1\u5bfcNK\u7ec6\u80de\u6740\u4f24\u4f5c\u7528\u7684\u65b9\u6cd5\u3002<\/p>\n<h3 style=\"padding-top: 10px;padding-bottom: 10px;font-weight: bold;font-size: 14px;font-family: Arial, \u9ed1\u4f53;text-decoration: underline;color: rgb(41, 128, 185);\">\u5019\u9009\u4ea7\u54c1AFM13\u548cAFM24<\/h3>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u5019\u9009\u4ea7\u54c1AFM13\u53ef\u7528\u4e8e\u6cbb\u7597\u4e00\u4e9b\u8868\u8fbeCD30\u7684B\u7ec6\u80de\u548cT\u7ec6\u80de\u6076\u6027\u80bf\u7624\uff0c\u6bd4\u5982\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002AFM13\u5305\u542b\u7ed3\u5408CD30\u7684\u4e24\u4e2a\u7ed3\u5408\u4f4d\u70b9\u548c\u7ed3\u5408CD16A\u7684\u4e24\u4e2a\u7ed3\u5408\u4f4d\u70b9\uff0c\u53ef\u4ee5\u8bf1\u5bfcNK\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u53d1\u52a8\u653b\u51fb\uff0c\u5f15\u53d1ADCC\u6548\u5e94\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\"><strong style=\"color: rgb(218, 18, 42);\">AFM13\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u7684\u4e34\u5e8a\u8fdb\u5c55\u6700\u5feb\uff0c\u5df2\u7ecf\u5904\u4e8e\u4e34\u5e8a\u4e8c\u671f\u9636\u6bb5\uff0c\u4e0eMerck\u7684Keytruda<sup>\u00ae<\/sup>\u8054\u7528\u6b63\u5904\u4e8e\u4e34\u5e8a\u4e00\u671f\u9636\u6bb5<\/strong><strong style=\"color: rgb(218, 18, 42);\">\u3002<\/strong><\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">2016\u5e74\u8d77\uff0cAffimed\u9012\u4ea4\u7684PCT\/EP2016\/060113\u4e13\u5229\u5bb6\u65cf\u8bf7\u6c42\u4fdd\u62a4\u4f7f\u7528\u7279\u5f02\u6027\u7ed3\u5408CD30\u548cCD16A\u7684\u591a\u529f\u80fd\u6297\u4f53\u4e0e\u6297PD-1\u6297\u4f53\u7684\u8054\u5408\u836f\u7269\u6cbb\u7597\u80bf\u7624\u7684\u7528\u9014\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u9664\u4e86\u6cbb\u7597\u8840\u6db2\u80bf\u7624\u5916\uff0cAffimed\u8fd8<strong style=\"color: rgb(218, 18, 42);\">\u5f00\u53d1\u4e86\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u5019\u9009\u4ea7\u54c1AFM24 (EGFR\/CD16A)<\/strong>\uff0c\u6b63\u5904\u4e8e\u4e34\u5e8a\u524d\u5f00\u53d1\u9636\u6bb5\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u5176\u4e2d\uff0cPCT\/EP2014\/002177\u4e13\u5229\u5bb6\u65cf\u6d89\u53ca\u4fdd\u62a4AFM24\uff0c\u5e76\u8fdb\u5165\u4e86US\u3001EP\u3001CN\u7b49\u56fd\u5bb6\u9636\u6bb5\u3002\u6bd4\u5982\uff0c\u8fdb\u5165\u4e2d\u56fd\u56fd\u5bb6\u9636\u6bb5\u7684CN105555804A\u6743\u5229\u8981\u6c421\u6d89\u53ca\u4e00\u79cdEGFRvIII\u7ed3\u5408\u86cb\u767d\uff0c\u5177\u6709\u81f3\u5c11\u4e00\u4e2aEGFRvIII\u7ed3\u5408\u4f4d\u70b9\uff0c\u5305\u542b\u6297\u4f53\u53ef\u53d8\u91cd\u94fe\u7ed3\u6784\u57df\u548c\/\u6216\u6297\u4f53\u53ef\u53d8\u8f7b\u94fe\u7ed3\u6784\u57df\uff0c\u5e76\u9650\u5b9a\u4e86CDR\u5e8f\u5217\u3002<\/p>\n<h2 style=\"margin-top: 5px;margin-bottom: 5px;padding: 5px 10px;font-family: Arial, \u9ed1\u4f53;border-width: 1px 1px 1px 3px;border-style: solid;border-color: rgb(41, 128, 185);line-height: 20px;\">\u901a\u8fc7\u7ed3\u5408CD3\u62db\u52dfT\u7ec6\u80de\u7684TandAb<\/h2>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u62db\u52dfT\u7ec6\u80de\u7684TandAb\u53ef\u4ee5<strong style=\"color: rgb(218, 18, 42);\">\u540c\u65f6\u7ed3\u5408\u80bf\u7624\u6297\u539f\u548cT\u7ec6\u80de\u8868\u9762\u7684CD3<\/strong>\uff0c\u5bf9CD3\u7684\u4eb2\u548c\u529b\u540c\u6837\u53ef\u4ee5\u8fbe\u5230\u7eb3\u6469\u5c14\u7ea7\u522b\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u5019\u9009\u4ea7\u54c1AFM11\u5305\u542b\u9776\u5411CD19\u7684\u4e24\u4e2a\u7ed3\u5408\u4f4d\u70b9\u548c\u9776\u5411CD3\u7684\u4e24\u4e2a\u7ed3\u5408\u4f4d\u70b9\uff0cCD19\u662f\u5f15\u53d1\u767d\u8840\u75c5\u6216\u6dcb\u5df4\u7624\u7684B\u7ec6\u80de\u8868\u9762\u6297\u539f\u3002AFM11\u53ef\u4ee5\u8bf1\u5bfcT\u7ec6\u80de\u7ed3\u5408\u80bf\u7624\u7ec6\u80de\uff0c\u5e76\u4f7f\u5176\u53d1\u6325\u7ec6\u80de\u6740\u4f24\u4f5c\u7528\u3002<\/p>\n<p><img class=\"\"     style=\"margin-right: auto;margin-left: auto;display: block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537926475.jpeg\" alt=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\" title=\"\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684Affimed\"  \/><\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">2015\u5e74\u9012\u4ea4\u7684PCT\/EP2015\/068070\u4e13\u5229\u5bb6\u65cf\uff0c\u6d89\u53ca\u4e00\u79cd\u6297\u539f\u7ed3\u5408\u86cb\u767d\uff0c\u5176\u5305\u542b\u81f3\u5c11\u4e00\u4e2aCD3\u7ed3\u5408\u4f4d\u70b9\uff0c\u9650\u5b9a\u4e86\u91cd\u94fe\u548c\u8f7b\u94fe\u53ef\u53d8\u7ed3\u6784\u57df\u7684\u5e8f\u5217\u3002\u8be5PCT\u7533\u8bf7\u4e5f\u8fdb\u5165\u4e86\u4e2d\u56fd\u56fd\u5bb6\u9636\u6bb5\u3002<\/p>\n<h2 style=\"margin-top: 5px;margin-bottom: 5px;padding: 5px 10px;font-family: Arial, \u9ed1\u4f53;border-width: 1px 1px 1px 3px;border-style: solid;border-color: rgb(41, 128, 185);line-height: 20px;\">\u8bc6\u522b\u4e24\u79cd\u80bf\u7624\u9776\u6807\u7684\u4e09\u7279\u5f02\u6027\u6297\u4f53 (Trispecific Abs)<\/h2>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">Affimed\u8fd8\u5728\u4e0d\u65ad\u53d1\u5c55\u5176\u5e73\u53f0\u6280\u672f\uff0c\u6bd4\u5982<strong style=\"color: rgb(218, 18, 42);\">\u5f00\u53d1\u4e86\u80fd\u591f\u8bc6\u522b\u4e24\u79cd\u4e0d\u540c\u80bf\u7624\u6297\u539f\u7684\u4e09\u7279\u5f02\u6027\u6297\u4f53\uff0c\u53ef\u4ee5\u8fdb\u4e00\u6b65\u63d0\u9ad8\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u7ed3\u5408\u7279\u5f02\u6027<\/strong>\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u4e3a\u6b64\uff0cAffimed\u4e8e2015\u5e744\u6708\u9012\u4ea4\u4e86\u6d89\u53ca\u4e09\u7279\u5f02\u6027\u6297\u539f\u7ed3\u5408\u5206\u5b50\u7684PCT\u56fd\u9645\u7533\u8bf7 (PCT\/EP2015\/057919)\uff0c\u5e76\u9646\u7eed\u8fdb\u5165\u4e86US\u3001CN\u3001EP\u7b49\u591a\u4e2a\u56fd\u5bb6\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u5176\u4e2d\uff0cPCT\/EP2015\/057919\u4ee5bypass\u9014\u5f84 (\u5373\u65c1\u8def\u9014\u5f84)\u8fdb\u5165\u7f8e\u56fd\u56fd\u5bb6\u9636\u6bb5 (US20170037128A1)\uff0c\u5c1a\u5904\u4e8e\u5ba1\u67e5\u9636\u6bb5\uff0c\u516c\u5f00\u7684\u6743\u5229\u8981\u6c421\u8bf7\u6c42\u4fdd\u62a4\u4e00\u79cd\u4e09\u7279\u5f02\u6027\u6297\u539f\u7ed3\u5408\u5206\u5b50\uff1a<\/p>\n<blockquote>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u201cA trispecific antigen-binding molecule, wherein the antigen-binding molecule is at least tetravalent and comprises an antigen-binding site having specificity against a first antigen epitope, an antigen-binding site having specificity against a second antigen epitope and two antigen-binding sites having specificity against a third antigen epitope.\u201d<\/p>\n<\/blockquote>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u6743\u5229\u8981\u6c42\u4e2d\u9650\u5b9a\u6297\u539f\u7ed3\u5408\u5206\u5b50\u81f3\u5c11\u662f\u56db\u4ef7\u7684\uff0c\u4e14\u5305\u542b\u7ed3\u5408\u7b2c\u4e00\u6297\u539f\u8868\u4f4d\u7684\u4e00\u4e2a\u6297\u539f\u7ed3\u5408\u4f4d\u70b9\u3001\u9776\u5411\u7b2c\u4e8c\u6297\u539f\u8868\u4f4d\u7684\u4e00\u4e2a\u6297\u539f\u7ed3\u5408\u4f4d\u70b9\u548c\u9776\u5411\u7b2c\u4e09\u6297\u539f\u8868\u4f4d\u7684\u4e24\u4e2a\u6297\u539f\u7ed3\u5408\u4f4d\u70b9\u3002\u53ef\u89c1\uff0c<strong style=\"color: rgb(218, 18, 42);\">US20170037128A1\u7684\u4fdd\u62a4\u8303\u56f4\u5341\u5206\u5bbd\u6cdb\uff0c\u662f\u4e00\u4e2a\u6d89\u53ca\u5e73\u53f0\u6280\u672f\u7684\u4e13\u5229\u7533\u8bf7<\/strong>\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\"><strong style=\"color: rgb(218, 18, 42);\">\u800c\u8fdb\u5165\u4e2d\u56fd\u56fd\u5bb6\u9636\u6bb5\u7684\u4e13\u5229\u7533\u8bf7CN106661108A\u4e5f\u5df2\u8fdb\u5165\u5b9e\u5ba1\u9636\u6bb5\uff0c\u82e5\u80fd\u83b7\u5f97\u6388\u6743\uff0c\u81f3\u5c11\u5c06\u81f32035\u5e74\u5230\u671f\uff0c\u76f8\u5173\u7ade\u4e89\u5bf9\u624b\u9700\u76d1\u63a7\u8be5\u4e13\u5229\u7533\u8bf7\u7684\u72b6\u6001\u3002<\/strong><\/p>\n<section class=\"h1-prefix\" style=\"padding-top: 20px;text-align: center;font-size: 18px;color: rgb(218, 18, 42);\">\u25bc<\/section>\n<h1 style=\"padding-bottom: 20px;font-size: 18px;text-align: center;font-family: Arial, \u9ed1\u4f53;color: rgb(218, 18, 42);\">\u9ad8\u8d28\u91cf\u7684\u4e13\u5229\u7ec4\u5408\u4e3a\u7ade\u4e89\u5bf9\u624b\u8bbe\u4e0b\u91cd\u91cd\u969c\u788d<\/h1>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">Affimed\u7684\u4e13\u5229\u7533\u8bf7\u7b56\u7565\u6709\u4e24\u4e2a\u7279\u70b9\uff1a<\/p>\n<blockquote>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u4e00\u65b9\u9762\uff0c\u4ee5\u9012\u4ea4\u4e00\u4e2aPCT\u7533\u8bf7\u5e76\u8fdb\u5165\u5404\u4e2a\u76f8\u5173\u7684\u56fd\u5bb6\u9636\u6bb5\u4e3a\u7279\u5f81\uff0c\u8fd9\u4e9b\u56fd\u5bb6\u4ee5\u540e\u90fd\u662fAffimed\u7784\u51c6\u7684\u6f5c\u5728\u5e02\u573a\u3002<\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\">\u53e6\u4e00\u65b9\u9762\uff0c\u5148\u56f4\u7ed5\u5176\u5e73\u53f0\u6280\u672f\u8fdb\u884c\u4e13\u5229\u7533\u8bf7\uff0c\u5373\u4fdd\u62a4\u5e73\u53f0\u6280\u672f\u7684\u57fa\u7840\u4e13\u5229\uff08\u7533\u8bf7\uff09\uff0c\u4e4b\u540e\u518d\u7d27\u5bc6\u56f4\u7ed5\u5176\u5177\u4f53\u5019\u9009\u4ea7\u54c1\u8fdb\u884c\u4e13\u5229\u4fdd\u62a4\uff0c\u53ef\u8c13\u5e03\u4e0b\u4e86\u91cd\u91cd\u58c1\u5792\u3002<\/p>\n<\/blockquote>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 25px;\"><strong style=\"color: rgb(218, 18, 42);\">\u8fd9\u4e9b\u4e13\u5229\u58c1\u5792\u4f7f\u7ade\u4e89\u5bf9\u624b\u5f88\u96be\u901a\u8fc7\u89c4\u907f\u8bbe\u8ba1\u7684\u65b9\u5f0f\u6765\u964d\u4f4e\u4fb5\u6743\u98ce\u9669\uff0c\u800c\u53ea\u80fd\u901a\u8fc7\u6240\u8c13license-in\u6216\u8bc9\u8bbc\u7684\u65b9\u5f0f\u5e94\u5bf9\u98ce\u9669\u3002\u800c\u9ad8\u8d28\u91cf\u7684\u4e13\u5229\u7ec4\u5408\u751a\u81f3\u8feb\u4f7f\u4e00\u90e8\u5206\u7ade\u4e89\u5bf9\u624b\u79bb\u5f00\u5e02\u573a<\/strong><strong style=\"color: rgb(218, 18, 42);\">\u3002<\/strong><\/p>\n<p style=\"padding: 10px;color: rgb(46, 46, 46);font-size: 15px;line-height: 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